Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 − the “plunger” − pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex − the “barrel” − into the matrix of the organelle. Notably, insertion of cargo-loaded receptor into the “barrel” is an ATP-independent process, whereas extraction (...) of the receptor back into the cytosol requires its monoubiquitination and the action of ATP-dependent mechanoenzymes. Here, we review the main data behind this model. The peroxin PEX5 is the peroxisomal matrix protein receptor. It shuttles between the cytosol and the organelle membrane, where it gets inserted into the docking/translocation module, thus pushing the cargo-protein into the peroxisome lumen. Resetting the system involves PEX5 monoubiquitination and its extraction from the membrane by the AAA-ATPases, PEX1/PEX6. (shrink)

Lozano-Vásquez, Andrea y Meléndez, Germán, comps. Convertir la vida en arte: una introducción histórica a la filosofía como forma de vida. Bogotá: Universidad Nacional de Colombia, 2016. 389 pp.

El presente artículo pretende dar cuenta de cómo el pensamiento de Slavoj Žižek posibilita el diagnóstico, la comprensión y la interpretación de nuevas o diversas formas de confrontación de algunas de las crisis más importantes de este tiempo, para lo cual esta investigación partió del estudio del concepto de crisis en el pensamiento del filósofo esloveno y de la descripción breve de algunos hechos que podrían considerarse como críticos o verdaderas crisis de este tiempo. Posteriormente se realizó un análisis de (...) la teoría del acontecimiento desarrollada por Žižek en varias de sus obras, para finalizar con algunas recomendaciones y reflexiones en torno a la forma en que el pensamiento de dicho autor posibilita tanto una nueva comprensión de las crisis, como la construcción de alternativas y focos de atención que constituyan, en sí mismos, nuevas formas de confrontación de ellos. El método empleado para realizar el abordaje así propuesto fue el hermenéutico, el instrumento fue el estudio bibliográfico y la técnica de análisis de información fue el análisis del discurso. (shrink)

El artículo intenta reflexionar sobre cierta renuencia y aparente desinterés de las mujeres (que a veces se pretende interpretar como incapacidad) para intervenir y competir en las ramas más duras de la ciencia, así como en elevadas posiciones en el campo de la política. Las interpretaciones habituales olvidan la vigencia de un modelo esencialmente androcéntrico, anclado en la subjetividad y el género, en la concepción del sujeto de la ciencia y de la ciudadanía. No pueden discutirse meramente las condiciones de (...) acceso de las mujeres a las instituciones, sin discutir primero la legitimidad de un modelo que se pretende neutro, genuino reflejo de la naturaleza, en el caso de la ciencia o de la «condición humana», en política. Esta discusión adquiere especial relieve en el contexto latinoamericano, cuando no se hace lugar al debate geopolítico sobre centro y periferia. (shrink)

Musical ensemble performances provide an ideal environment to gain knowledge about complex human interactions. Network structures of synchronization can reflect specific roles of individual performers on the one hand and a higher level of organization of all performers as a superordinate system on the other. This study builds on research on joint singing, using hyperscanning of respiration and heart rate variability from eight professional singers. Singers performed polyphonic music, distributing their breathing within the same voice and singing without and with (...) physical contact: that is touching each other's shoulder or waist. The idea of singing with touch was motivated by historical depictions of ensemble performances that showed singers touching each other. It raises the question of the potential benefit of touch for group performances. From a psycho-physiological point of view, physical contact should increase the synchronization of singing coordination. The results confirm previous findings on synchronization of respiration and HRV during choir singing and extend those findings to a non-homophonic musical repertoire while also revealing an increase in synchronization in respiration during physical contact. These effects were significant across different frequency ranges. The effect of physical contact was stronger when all singers were singing in comparison to the partial ensemble. Importantly, the synchronization could not be fully explained by the singing action or by the standing position or touch. This finding suggests a higher level of organization of all singers, forming a superordinate system. (shrink)

The recent availability of multiple avian genomes has laid the foundation for a huge variety of comparative genomics analyses including scans for changes and signatures of selection that arose from adaptions to new ecological niches. Nocturnal adaptation in birds, unlike in mammals, is comparatively recent, a fact that makes birds good candidates for identifying early genetic changes that support adaptation to dim‐light environments. In this review, we give examples of comparative genomics analyses that could shed light on mechanisms of adaptation (...) to nocturnality. We present advantages and disadvantages of both “data‐driven” and “hypothesis‐driven” approaches that lead to the discovery of candidate genes and genetic changes promoting nocturnality. We anticipate that the accessibility of multiple genomes from the Genome 10K Project will allow a better understanding of evolutionary mechanisms and adaptation in general. -/- . (shrink)

Zika infection in pregnant women is associated with an elevated probability of giving birth to a child with microcephaly and multiple other disabilities. Public health messaging on Zika prevention has predominantly targeted women who know they are pregnant or intend to become pregnant, but not teenage females for whom unintended pregnancy is more likely. Vulnerabilities among this population to reproductive risks associated with Zika are further amplified by restrictive abortion laws in several Zika-impacted states. Key to prevention is enhanced, targeted (...) public health messaging centered on teens nationally and particularly in certain high-risk regions. (shrink)

We take our own life stories as points of departure to look at some of the ways in which women were politicized in Argentina and West Germany (our respective countries of origin), focusing on similarities as well as differences in our politicization processes. We aim at putting present discussions about global political movements into a historical perspective. We want also to illuminate the centrality of political identities in the construction of specific (gendered) subjectivities. Our focus lies on theorizing the ways (...) through which privileged (gendered) identities critically re-read their own position and transform their own understanding of themselves and the world through the field of the political. Methodologically, we want to contribute to ways of re-thinking Feminist methodologies by experimenting with a form of analysis in which we are alternately the subject and the object of our research process. The aim of this intervention is to transgress the binary oppositions between researcher/researched and challenge traditional understanding of social science where researchers provide analysis and informants have ‘experience’. One of our conclusions is that the 68 movement provided subject positions for living alternative normalities as an ‘insider-outside’, that is, for those who belonged to normalized groups in their respective societies, but for different reasons (of which we analyse some concerning our formation as ‘women’) could not identify with the dominant normalities offered to them. At the same time, the dominant male instrumentality of the movement estranged (some) women and allowed them (or forced them into) a kind of distanced engagement that, perhaps paradoxically, provided a basis for sustaining their political subjectivities through transformative experiences of defeat. (shrink)

Ethnic minority status and female gender convey a risk for suicidal behavior, yet research of suicidality of ethnic minority female immigrants is scarce. The authors of this article conducted qualitative interviews with 15 young women in the Netherlands, who either had attempted suicide or contemplated suicide, and analyzed these in a narrative psychology tradition. Suicidality was associated with despair and frustration over the violation of the women’s personal autonomy and self-integrity regarding strategic life choices. Autonomy restrictions and violations followed two (...) patterns, which are interconnected with four criteria regarding the capacity for autonomy. Findings are discussed with referral to Durkheim and feminist theories of autonomy. (shrink)

This article focuses on key features of the use of sex and gender in titles of articles about women, science, and engineering over an important forty-six-year period. The focus is theoretically and empirically consequential. Theoretically, the paper addresses science as a critical case that connects femininity/masculinity to social stratification; and the use of sex and gender as an enduring, analytical issue that reveals perspectives on hierarchies of femininity/masculinity. Empirically, this article identifies the emergence, development, and stabilization of published articles about (...) women, science, and engineering that use sex and gender in their titles. The distinctive method involves search, retrieval, and review of 23,430 articles, using intercoder reliabilities for inclusion/exclusion. This results in a uniquely specified and comprehensive set of articles on our subject and the identification of titles with sex and gender. Findings point to the growth of gender titles, their increase in every field, differing concentrations of sex and gender titles in journals, a span of telling topic areas, and higher citation rates of gender, compared to sex, titles. Broader implications appear in reasons for the growth of gender titles, meanings of topic areas that occur, insights into social inequalities and science policies, and emerging complexities of nonbinary categories of sex/gender. (shrink)

Provides an introduction to a vast array of scholarly perspectives on emergent technologies and biotechnologies used to modify or augment the capabilities of human beings.

Churches and communities of believers live their faith through a disposition and supportive attitude toward disadvantaged groups, this way they become a social network of support to the neediest. The processes of social integration are softened and problems arising are therefore solved more successfully, this is especially important when a new vital project starts or someone enters in a new society, as in the case of immigration. This research analyzes the role of social welfare networks of minority religions and the (...) social action they do. After a reflection on the social dimension of the concept of solidarity and the function of solidarity in religion, we collect the experiences of the protagonists, through semi-structured interviews on the role of the community of believers in the social integration of newcomers. (shrink)

Peter Zachar. A Metaphysics of Psychopathology. Cambridge, MA: MIT. Press, 2014. 274 pp.

New Materialisms brings into focus and explains the significance of the innovative materialist critiques that are emerging across the social sciences and humanities. By gathering essays that exemplify the new thinking about matter and processes of materialization, this important collection shows how scholars are reworking older materialist traditions, contemporary theoretical debates, and advances in scientific knowledge to address pressing ethical and political challenges. In the introduction, Diana Coole and Samantha Frost highlight common themes among the distinctive critical projects that (...) comprise the new materialisms. The continuities they discern include a posthumanist conception of matter as lively or exhibiting agency, and a reengagement with both the material realities of everyday life and broader geopolitical and socioeconomic structures. Coole and Frost argue that contemporary economic, environmental, geopolitical, and technological developments demand new accounts of nature, agency, and social and political relationships; modes of inquiry that privilege consciousness and subjectivity are not adequate to the task. New materialist philosophies are needed to do justice to the complexities of twenty-first-century biopolitics and political economy, because they raise fundamental questions about the place of embodied humans in a material world and the ways that we produce, reproduce, and consume our material environment. Contributors Sara Ahmed Jane Bennett Rosi Braidotti Pheng Cheah Rey Chow William E. Connolly Diana Coole Jason Edwards Samantha Frost Elizabeth Grosz Sonia Kruks Melissa A. Orlie. (shrink)

Meyers examines the question of personal autonomy. She observes the effects of childrearing practices and sexual biases, and reflects upon the results in women. Annotation copyrighted by Book News, Inc., Portland, OR.

In this brief and powerful book, Diana Fuss takes on the debate of pure essence versus social construct, engaging with the work of Luce Irigaray and Monique ...

A critical analysis of Diana Fuss's Essentially Speaking: Feminism, Nature, and Difference and Elizabeth Grosz's Sexual Subversions: Three French Feminists.

What is sportsmanship? Following Keating, we may say that sportsmanship is conduct befitting a person involved in sports. This raises the question of what kind of activity exactly sport is. This is notoriously difficult to answer, but roughly speaking, sport is a rule-governed activity that is about excellence, an understanding of how to play the game, and, in competitive sports, winning. Accordingly, there are four elements of sportsmanship: fairness, equity, good form and the will to win. These four elements are (...) equally important and not reducible to one another. Yet, the will to win is in systematic conflict with the other three elements. Hence, sportsmanship is not only compromised of these four elements, but also requires that a balance be held between them. (shrink)

This study tests a model that links stakeholder pressure to the implementation of corporate social responsibility activities and market performance. Stakeholder groups and competitors might exert pressure on companies to implement CSR, which could lead to positive effects on market performance. Using structural equation modeling, the authors find that stakeholders and competitors exert pressure differently. The effect of CSR implementation on market performance is moderated by market dynamism: It affects market performance more in dynamic environments. The authors discuss implications for (...) both companies and stakeholders. (shrink)

Diana Lobel takes readers on a journey across Eastern and Western philosophical and religious traditions to discover a beauty and purpose at the heart of reality that makes life worth living. Guided by the ideas of ancient thinkers and the insight of the philosophical historian Pierre Hadot, _The Quest for God and the Good_ treats philosophy not as an abstract, theoretical discipline, but as a living experience. For centuries, human beings have struggled to know why we are here, whether (...) a higher being or dimension exists, and whether our existence is fundamentally good. Above all, we want to know whether the search for God and the good will bring happiness. Following in the path of the ancient philosophers, Lobel directly connects conceptions of God or an Absolute with notions of the good, illuminating diverse classical texts and thinkers. She explores the Bible and the work of Plato, Aristotle, Augustine, Maimonides, al-Farabi, and al-Ghazali. She reads the _Tao Te Ching_, _I Ching_, _Bhagavad Gita_, and _Upanishads_, as well as the texts of Theravada, Mahayana, and Zen Buddhism, and traces the repercussions of these works in the modern thought of Alfred North Whitehead, Iris Murdoch, Alasdair MacIntyre, and Charles Taylor. While each of these texts and thinkers sets forth a distinct and unique vision, all maintain that human beings find fulfillment in their contact with beauty and purpose. Rather than arriving at one universal definition of God or the good, Lobel demonstrates the aesthetic value of multiple visions presented by many thinkers across cultures. _The Quest for God and the Good_ sets forth a path of investigation and discovery culminating in intellectual and spiritual communion. (shrink)

¡PRESENTE! investigates the many answers to a seemingly simple question: What does it mean to be present? Performance studies scholar Diana Taylor answers that question by offering an expansive explication of presence as both ethical command and performative knowledge production. Taking the histories of state violence, colonialism, and imperialism as her starting point, Taylor situates being ¡Presente! as an embodied and performed practice of standing alongside those harmed by historical and ongoing violence. Noting that Present/e is simultaneously single and (...) plural in English and Spanish, and drawing on Jean Luc Nancy's formulation of being singular plural, Taylor asks how presence is imbricated in questions of subject formation and collectivity. She begins with reframing the racialization of Latin Americans as a coming into presence through colonial conquest-a presence not as subjects but as subjugated objects-and asks what was made absent through this racialized process. For Taylor, the epistemicide of Indigenous, Native, and African ways of knowing stands at the center of this process of presence and absence. To counter this ongoing epistemicide, Taylor situates ¡Presente! as a performative and decolonial mode of knowledge production that decenters European Enlightenment traditions and seriously takes up Native, Indigenous, and African ways of knowledge and temporality. Grounded in performance studies, this book links knowledge to action as a doing practice, or what Taylor calls a "peripatetic strategy" that emphasis movement in learning. This book offers an expansive theory of ¡Presente! in various locations and situations: the original colonial conquest of Columbus and the Spanish; the May 1968 student protests; a study in Zapatistan autonomy; the 43 disappeared students of Ayotzinapa; queer histories of Mexico; and the former torture centers of the Pinochet dictatorship. Throughout these varied locations, Taylor weaves a methodology, theory, and practice of ¡Presente!. This book will be of interest to students and scholars of performance studies, Latin American studies, American studies, critical ethnic studies, colonial, decolonial, and postcolonial studies, and queer theory. (shrink)

The primary focus of this work is to show that it is possible to find a certain way to think the community, a very different kind of community to those ways of conceiving the community from a certain dialectic of inclusion and exclusion, defining an inside and an outside of the collective, a proper and improper. In that sense, we believe that through the aforementioned work emerges a concern for the community but in a rather shifted from how we usually (...) think this. When we think about a community experience through The Nights of Labor we refer to a certain attitude that opens possibilities of change and possibilities of being-in-common. (shrink)

Diana Tietjens Meyers examines the political underpinnings of psychoanalytic feminism, analyzing the relation between the nature of the self and the structure of good societies. She argues that impartial reason--the approach to moral reflection which has dominated 20th-century Anglo-American philosophy--is inadequate for addressing real world injustices. ____Subjection and Subjectivity__ is central to feminist thought across a wide range of disciplines.

In Unruly Words, Diana Raffman advances a new theory of vagueness which, unlike previous accounts, is genuinely semantic while preserving bivalence. According to this new approach, called the multiple range theory, vagueness consists essentially in a term's being applicable in multiple arbitrarily different, but equally competent, ways, even when contextual factors are fixed.

Calm is a little-theorized but important link between Roland Barthes and Samuel Beckett. Beginning with Beckett, moving on to Barthes, and then interleaving the two, this paper proposes calm as a ‘scandalous’ category not reducible to kindred states like languor or apatheia. In dialogue with theorists of repose, such as Kant and De Quincey, calmness becomes less a sedated condition than an interactive process, entailing intense sensitivity to the fluctuations of what Barthes calls ‘the affective minimal’. Artistically generative, this ‘emotive (...) lucidity’ encourages inquisitiveness towards the natural world, and enables in both writers specific writing practices — from lists to notation to haiku. (shrink)

Elizabeth Hackett and Sally Haslanger, Theorizing feminisms: A reader, New York: Oxford University Press, 2006, reviewed by Diana Buccafurni.

In lieu of an abstract, here is a brief excerpt of the content:Then Artemis Said DIANA LUEPTOW Then Artemis said, because our mother found no home but an island dragging anchor, a safe child will never be delivered. arion 26.3 winter 2019...