Objectives The study uses a qualitative empirical method to define Health Research for Development. This project explores the perspectives of stakeholders in an international health research partnership operating in Ghana and Tanzania. Methods We conducted 52 key informant interviews with major stakeholders in an international multicenter partnership between GlaxoSmithKline and the global health nonprofit organisation PATH and its Malaria Vaccine Initiative program,. The respondents included teams from four clinical research centres and various collaborating partners. This paper analyses responses to the (...) question: What is Health Research for Development? Results Based on the stakeholders’ experience the respondents offered many ways of defining Health Research for Development. The responses fell into four broad themes: i) Equitable Partnerships; ii) System Sustainability; iii) Addressing Local Health Targets, and iv) Regional Commitment to Benefit Sharing. Conclusion Through defining Health Research for Development six key learning points were generated from the four result themes: 1) Ensure there is local research leadership working with the collaborative partnership, and local healthcare system, to align the project agenda and activities with local research and health priorities; 2) Know the country-specific context - map the social, health, legislative and political setting; 3) Define an explicit development component and plan of action in a research project; 4) Address the barriers and opportunities to sustain system capacity. 5) Support decentralised health system decision-making to facilitate the translation pathway; 6) Govern, monitor and evaluate the development components of health research partnerships. Overall, equity and unity between partners are required to deliver health research for development. (shrink)

Recent studies reported the development of psychological distress symptoms in patients who recovered from COVID-19. However, evidence is still scarce and new data are needed to define the exact risk and protective factors that can explain the variability in symptoms manifestation. In this study, we enrolled 257 patients who recovered from COVID-19 and we evaluated the levels of psychological distress through the Symptoms Checklist-90-R scale. Data concerning illness-related variables were collected from medical records, while the presence of subjective cognitive difficulties, (...) both before and after the illness, as well as the level of the cognitive reserve, were assessed over a clinical interview. Results revealed that being female and reporting the presence of subjective cognitive difficulties after COVID-19 were associated with higher levels of psychological distress. At the same time, being admitted to the hospital and having a high CR were protective factors. Adding new information to this emerging research field, our results highlight the importance of a complete psychological and cognitive assessment in patients with COVID-19. (shrink)

Abstractβ‐Catenin/CTNNB1 is critical for leukemia initiation or the stem cell capacity of several hematological malignancies. This review focuses on a general evaluation of β‐catenin function in normal T‐cell development and T‐cell acute lymphoblastic leukemia (T‐ALL). The integration of the existing literature offers a state‐of‐the‐art dissection of the complexity of β‐catenin function in leukemia initiation and maintenance in both Notch‐dependent and independent contexts. In addition, β‐catenin mutations are screened for in T‐ALL primary samples, and it is found that they are rare (...) and with little clinical relevance. Transcriptional analysis of Wnt family members (Ctnnb1, Axin2, Tcf7, and Lef1) and Myc in different publicly available T‐ALL cohorts indicates that the expression of these genes may correlate with T‐ALL subtypes and/or therapy outcomes. (shrink)

«Quando entro in una macelleria, mi stupisco sempre di non esserci io, lì appeso, al posto dell’animale». Così il pittore Francis Bacon in una conversazione con David Sylvester, che Mauro Carbone riprende e discute nel volume agile e prezioso, che qui presentiamo, dedicato alla nozione di “carne”. Una nozione che, pur antichissima nella storia della cultura europea, torna d’attualità nel dibattito filosofico contemporaneo con la fenomenologia e con il suo progetto di ricondurre l’esperienza,...

«Quando entro in una macelleria, mi stupisco sempre di non esserci io, lì appeso, al posto dell’animale». Così il pittore Francis Bacon in una conversazione con David Sylvester, che Mauro Carbone riprende e discute nel volume agile e prezioso, che qui presentiamo, dedicato alla nozione di “carne”. Una nozione che, pur antichissima nella storia della cultura europea, torna d’attualità nel dibattito filosofico contemporaneo con la fenomenologia e con il suo progetto di ricondurre l’esperienza,...

My claim in this article is that the thesis that Buddhism has no God, insofar as it is taken to apply to Buddhism universally, is false. I defend this claim by interpreting a central text in East-Asian Buddhism – The Awakening of Faith in Mahāyāna – through the lenses of perfect being theology (PBT), a research programme in philosophy of religion that attempts to provide a description of God through a two-step process: (1) defining God in terms of maximal greatness; (...) (2) inferring the properties or attributes that God must have in virtue of satisfying the definition. My argument comprises two steps. First, I argue that, since PBT is a method for providing a description of God starting from a definition of God, any text that contains a PBT ipso facto contains a notion of God. Second, I argue through textual evidence that The Awakening articulates a PBT, concluding that it contains a notion of God. Since the method of PBT leaves open what descriptions are to be inferred, my argument allows me to conclude that a text contains a notion of God without previously committing to any particular conception of the divine, which makes it particularly versatile and powerful. (shrink)

Baker claims to provide an example of mathematical explanation of an empirical phenomenon which leads to ontological commitment to mathematical objects. This is meant to show that the positing of mathematical entities is necessary for satisfactory scientific explanations and thus that the application of mathematics to science can be used, at least in some cases, to support mathematical realism. In this paper I show that the example of explanation Baker considers can actually be given without postulating mathematical objects and thus (...) cannot be used by the mathematical realist. I also show that, despite this, mathematics keeps playing an important methodological role in the explanation and does not reduce to a merely computational or descriptive framework. (shrink)

The contemporary discussion on the subjective character of conscious experience is characterized by a stark contrast between higher-order intentionalism, according to which any state of awareness depends on the instantiation of intentional properties by mental states, and anti-intentionalism, according to which the inner awareness constitutive of subjective experience is fundamentally different from ordinary instances of external or introspective awareness, in that one’s experience is not given to the subject as an ordinary intentional object. The purpose of this paper is to (...) outline the most fundamental dimensions of variation among the different kinds of higher-order theories and to show, by providing a comprehensive analysis of the logical space available, that these seemingly incompatible views can be reconciled within an intentionalist framework. (shrink)

Prologue : narratocracy and the contours of political life -- From nomos to nomad : Kant, Deleuze, and Rancière on sensation -- The piazza, the edicola, and the noise of the utterance -- Machiavelli's theory of sensation and Florence's vita festiva -- The viewing subject : Caravaggio, Bacon, and the ring -- "You're eating too fast!" slow food's ethos of convivium -- Epilogue : "the photographs tell it all" : on an ethics of appearance.

Set-theoretic potentialism is one of the most lively trends in the philosophy of mathematics. Modal accounts of sets have been developed in two different ways. The first, initiated by Charles Parsons, focuses on sets as objects. The second, dating back to Hilary Putnam and Geoffrey Hellman, investigates set-theoretic structures. The paper identifies two strands of open issues, technical and conceptual, to clarify these two different, yet often conflated, views and categorize the potentialist approaches that have emerged in the contemporary debate. (...) The final outcome is a taxonomy that should help researchers navigate the rich landscape of modal set theories. (shrink)

In September 2019, the European Parliament adopted a resolution that sparked controversy due to its equation of Nazism and Communism. The document made the USSR jointly responsible for the outbreak of the Second World War and accused the Russian government of whitewashing communist crimes and glorifying the Soviet totalitarian regime. This article presents the resolution as the latest expression of a broader discursive process that started with the accession process of the Central and Eastern European countries. To support this hypothesis, (...) I examine the genealogy of the resolution, namely the documents that originally outlined the stances expressed by the latter, as well as the debates at the EU Parliament that preceded its adoption. This analysis highlights in particular two fundamental tendencies, i.e. the entanglement of history and memory characterising the recent discourse on European integration and the frequent identification of the Central and Eastern European member states as victims. In the final paragraphs, I suggest that the construction of a shared ‘historical memory’ may represent a legitimising framework for the implementation of specific sets of political and economic ideas, but I also note that processes such as the one described in the article may ultimately damage the cohesion among the member states and the ability of the EU institutions to address relevant internal and external issues. (shrink)

The article is aimed at pointing out the correctness of the basic assumptions of Maurizio Ferraris’ documental theory of social reality, illustrating the results of a case study research. The theoretical analysis leads to an argument that shows that only the reference to the role of writing (and to a broad and diversified conception of Documentality) makes it possible to clarify the phenomenon of social and historical iteration of intellectual heritage. This latter represents an intangible heritage which is neither part (...) of the external perceivable world, nor of a conjectural platonic reality, since – though possessing abstract essence – it stems from a specific point in time. (shrink)

During the first wave of the COVID-19 pandemic in Italy, practitioners had to make tragic decisions regarding the allocation of scarce resources in the ICU. The Italian debate has paid a lot of attention to identifying the specific regulatory criteria for the allocation of resources in the ICU; in this paper, however, we argue that deciding such criteria is not enough for the implementation of fair and transparent allocative decisions. In this respect, we discuss three ethical issues: (a) in the (...) Italian context, the treating physician, rather than a separate committee, was generally the one responsible for the allocation decision; (b) although many allocative guidelines have supported moral equivalence between withholding and withdrawing treatments, some health professionals have continued to consider it a morally problematic aspect; and (c) the health workers who have had to make the aforementioned decisions or even only worked in ICU during the pandemic often experienced moral distress. We conclude by arguing that, even if these problems are not directly related to the above-mentioned issues of distributive justice, they can nevertheless directly affect the quality and ethics of the implementation of allocative criteria, regardless of those chosen. (shrink)

The notion of maximal greatness is arguably part of the very concept of God: something greater than God is not even possible. But how should we understand this notion? The aim of this paper is to provide a Śaivist answer to this question by analyzing the form of theism advocated in the Pratyabhijñā tradition. First, I extract a model of divine greatness, the Hierarchical Model, from Nagasawa’s work "Maximal God". According to the Hierarchical Model, God is that than which nothing (...) could be greater by virtue of being better suited than all other beings in relation to certain great-making properties (§1). I then offer an analysis of the form of theism advocated in the Pratyabhijñā tradition by discussing passages from the works of Somānanda, the founder of the Pratyabhijñā school, and of Utpaladeva, the most prominent of Somānanda’s disciples. I argue that the Pratyabhijñā theist cannot account for divine greatness in terms of the Hierarchical Model. My argument is that the Hierarchical Model requires a comparison between God and other beings that cannot be made with the Pratyabhijñā God (§2). Finally, I develop an original alternative model, the Unlimited Nature Model, that accounts for God’s maximal greatness in a way that suits Pratyabhijñā’s theism. According to the Unlimited Nature Model, the nature of all ordinary beings is metaphysically limited as a result of realizing only a small portion of the potential of what could be, and God is maximally great because only he has a completely unlimited nature (§3). (shrink)

This paper offers an original interpretation of the Daodejing 道德經 as containing a distinctive account of creation. In my reading, the Daodejing envisions the creation of the cosmos by Dao (1) as a movement from the absence of phenomenal forms to phenomenal forms and (2) as a movement from nothingness to existence. I interpret creation as a unique metaphysical operation that explains how (1) and (2) are possible. The paper is organized into two sections. First, I introduce the distinctions between (...) the lack and presence of phenomenal forms (§1.1) and between nothingness and existence (§1.2), using them to map the distinction between Dao and the created world. Then, I propose my account of the Daodejing’s metaphysics of creation (§2.1) and elaborate on its connection with the previously drawn distinctions while answering a potential objection (§2.2). I conclude with some considerations about the connections between the Daodejing’s view of creation and its soteriology. (shrink)

Nel 1881, per i tipi dell’editore Brigola di Milano, vedeva la luce Macchiette parigine, un compendio di profili biografici che lo scrittore siciliano Emanuele Navarro della Miraglia (1838-1919) dedicava a eminenti personalità della cultura letteraria e artistica francese di metà Ottocento.Francesista, a lungo residente a Parigi (1864-1872), in contatto a Milano con gli ambienti della scapigliatura lombarda (1872-1882) e da ultimo professore di Lingua e letteratura francese presso l’Istituto superiore di magistero femminile di Roma (1883-1913), Navarro della Miraglia includeva fra (...) le sue “macchiette” anche due ritratti d’artisti dedicati rispettivamente a Gustave Courbet e a Jean-Baptiste Carpeaux.Questo contributo si propone di definire il contesto e le ricadute di una lettura non allineata alla tempestiva e più “ortodossa” discussione della lezione di Courbet promossa da Diego Martelli presso i macchiaioli toscani, a beneficio di una geografia culturale diversamente articolata fra le aperture cosmopolite del naturalismo meridionale e le frange più avanzate della scapigliatura lombarda. Allo stesso modo il resoconto dell’atelier di Carpeaux è riconsiderato alla luce del coevo dibattito sulla scultura monumentale e delle ricerche in corso a Milano su un modellato più mosso e nervoso. (shrink)

What is knowledge? What should knowledge be like? Call an epistemological project that sets out to answer the first question ‘descriptive’ and a project that sets out to answer the second question ‘normative’. If the answers to these two questions don’t coincide—if what knowledge should be like differs from what knowledge is like—there is room for a third project we call ‘revisionary’. A revisionary project starts by arguing that what knowledge should be differs from what knowledge is. It then proposes (...) that we revise our account of knowledge accordingly. Our aim in this paper was to develop a methodology for revisionary projects in epistemology. Put roughly, the thought is that we start by looking at the various things that we expect knowledge to do for us. Once we have a list of the various things we expect knowledge to do for us we have a ‘job description’; a list of tasks we need done, and that we expect knowledge to perform. With the job description in hand, we can ask what knowledge would hav.. (shrink)

Peano's axiomatizations of geometry are abstract and non-intuitive in character, whereas Peano stresses his appeal to concrete spatial intuition in the choice of the axioms. This poses the problem of understanding the interrelationship between abstraction and intuition in his geometrical works. In this article I argue that axiomatization is, for Peano, a methodology to restructure geometry and isolate its organizing principles. The restructuring produces a more abstract presentation of geometry, which does not contradict its intuitive content but only puts it (...) into a particular form. (shrink)

We show that intuitionistic logic is deductively equivalent to Connexive Heyting Logic ($$\textrm{CHL}$$ CHL ), hereby introduced as an example of a strongly connexive logic with an intuitive semantics. We use the reverse algebraisation paradigm: $$\textrm{CHL}$$ CHL is presented as the assertional logic of a point regular variety (whose structure theory is examined in detail) that turns out to be term equivalent to the variety of Heyting algebras. We provide Hilbert-style and Gentzen-style proof systems for $$\textrm{CHL}$$ CHL ; moreover, we (...) suggest a possible computational interpretation of its connexive conditional, and we revisit Kapsner’s idea of superconnexivity. (shrink)

The concept of authority crosses many social sciences, but there is a lack of common taxonomy and definitions on this topic. The aims of this review are: to define the basic characteristics of the authority relationship, reaching a definition suitable for the different domains of social psychology and social sciences; to bridge the gap between individual and societal levels of explanation concerning the authority relationship, by proposing an interpretation within the framework of social representations. The authority relationship can be conceived (...) as a negotiation of meanings and it is closely linked to shared value orientation and the attribution of meanings negotiated within a society. We assume that the authority relationship is socially constructed and represents both a shared representation of society and a normative principle of social life. A multidisciplinary approach is adopted, crossing definitions and studies provided in sociology, political science, law and social psychology. (shrink)

In _The Poetics of Political Thinking_ Davide Panagia focuses on the role that aesthetic sensibilities play in theorists’ evaluations of political arguments. Examining works by thinkers from Thomas Hobbes to Jacques Rancière, Panagia shows how each one invokes aesthetic concepts and devices, such as metaphor, mimesis, imagination, beauty, and the sublime. He argues that it is important to recognize and acknowledge these poetic forms of representation because they provide evaluative standards that theorists use in appraising the value of ideas—ideas (...) about justice, politics, and democratic life. An investigation into the intertwined histories of aesthetic and political accounts of representation—such as Panagia presents here—sheds light on how modes of poetic thinking delimit the questions of unity and diversity that continue to animate contemporary political theory. Panagia not only illuminates the structure of much contemporary political theory but also shows why understanding the poetics of political thinking is vital to contemporary society. Drawing on Gilles Deleuze’s critique of negation and his privileging of paradox as the source of political thought, Panagia suggests that a non-teleological concept of difference might generate insight into pressing questions about foreignness and citizenship. Turning to the liberal/poststructural debate that dominates contemporary political theory, he compares John Rawls’s concept of justice to Rancière’s ideas about political disagreement in order to demonstrate how, despite their differences, both thinkers comprehend aesthetic and moral reasoning as part and parcel of political writing. Considering the writings of William Hazlitt and Jürgen Habermas, he describes how the essay has become the exemplary genre of what is considered rational political argument. _The Poetics of Political Thinking_ is a compelling reappraisal of the role of representation within political thought. (shrink)

The aim of the present contribution is to defend a specific version of moderate skeptical invariantism, which I call Practical Skeptical Invariantism (PSI). The view is a form of skepticism to the extent that it denies knowledge of many facts that we ordinarily think or claim to know. It is moderate to the extent that it is supposed to be compatible with a quite weak, non-radical form of skepticism. According to this view, the threshold on evidential support required for knowledge (...) should be partially fixed by the practical circumstances of the subject: someone is in a position to know a proposition p only if she would be rational to act as if p even if the practical stakes on p were maximally high. I consider and address what I take to be the most pressing problem for the view, namely, that the view can’t avoid a collapse into a radical form of skepticism. Moreover, I propose a positive argument for this view. The argument relies on the claim that judgments in high stakes are generally more reliable than in low stakes. (shrink)

Procreative obligations are often discussed by evaluating only the consequences of reproductive actions or omissions; less attention is paid to the moral role of intentions and attitudes. In this paper, I assess whether intentions and attitudes can contribute to defining our moral obligations with regard to assisted reproductive technologies already available, such as preimplantation genetic diagnosis (PGD), and those that may be available in future, such as reproductive genome editing and ectogenesis, in a way compatible with person‐affecting constraints. I propose (...) the parent–child relationship argument, which is based on the moral distinction between creating and parenting a child. Hence, I first argue that intentions and attitudes can play a role in defining our moral obligations in reproductive decisions involving PGD. Second, I maintain that if we accept this and recognize reproductive genome editing and ectogenesis as person‐affecting procedures, we should be committed to arguing that prospective parents may have moral reasons to prefer reproduction via such techniques than via sexual intercourse. In both cases, I observe an extension of our procreative responsibility beyond what is proposed by the consequentialist person‐affecting morality. (shrink)

Previous research on the interpersonal effects of emotions in negotiation suggested that bargainers obtain higher outcomes expressing anger, when it is not directed against the counterpart as a person and it is perceived as appropriate. Instead, other studies indicated that successful negotiators express positive emotions. To reconcile this inconsistency, we propose that the direction of the effects of emotions depends on their perceived target, that is, whether the negotiators’ emotions are directed toward their opponent’s proposals or toward their own ‘exit (...) option’. An ultimatum game scenario experiment showed that negotiators who express positive emotion rather than negative, in addition to benefits in terms of relationship fortification, received better offers when participants perceived the negotiators’ emotions directed toward their own ‘exit option’. These findings indicate that positive emotions may signal the availability of better ‘exit option’, suggesting that happiness expressions can be strategically used to maximize both material and relational outcomes. (shrink)

A arquitetura fenomenológica não possui talvez a solidez e a homogeneidade de uma escola ou de um movimento em sentido estrito, mas representa, no entanto, um vetor notável do pensamento arquitetônico contemporâneo. Juntamente com as obras de Heidegger, as obras de Merleau-Ponty são utilizadas com frequência por aqueles que se reconhecem como representantes de uma arquitetura de inspiração fenomenológica. Neste artigo será analisado o papel que o pensamento de Merleau-Ponty desenrola nas obras e no pensamento de Juhani Pallasmaa e Steven (...) Holl, autores que se destacam pela força de seus trabalhos e pela determinação de suas posições teóricas. Particular atenção se prestará à dupla oposição que caracteriza a arquitetura fenomenológica, que se distancia com igual firmeza tanto do modernismo como do pós-modernismo. Estes autores, na reivindicação da primazia do corpo vivido e da experiência perceptiva, consideram ter encontrado um “antídoto” à ossificação produzida pela racionalidade moderna, com seus espaços funcionais e inabitáveis, como também à celebração da autorreferencialidade de um certo pós-modernismo, com seus edifícios destinados essencialmente a serem contemplados pelos apreciadores. A partir dessa dupla oposição, a arquitetura fenomenológica parece procurar um plano mais sólido numa forte acentuação da positividade da experiência corpórea e perceptiva, quando Merleau-Ponty parece empenhado, pelo contrário, em uma progressiva revisão destes aspetos. (shrink)