Neurons are now known to produce a variety of types of chemical transmitters. Classical transmitters are stored within synaptic vesicles which undergo synaptic exocytosis in association with presynaptic thickenings. The larger, dense‐cored secretory granules present in most neurons contain neuropeptides and mainly discharge their contents at morphologically undifferentiated (i.e.nonsynaptic) sites. The synaptic character of vesicle discharge enables transmitters to exercise a highly focal action, whereas nonsynaptic release probably relates to the slow rate of degradation of many neuropeptides and their consequent (...) widespread diffusion and sphere of action. However, one variant of the basic pattern, involving the restriction of granule discharge to areas of the terminal plasmalemma situated adjacent to the postsynaptic cells (i.e. a parasynaptic configuration), enables a degree of targeted peptide discharge to be achieved. The diversity of patterns of neural exocytosis adds a further dimension to the complexity of nervous function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Feminism and Classics:Framing the Research AgendaBarbara K. GoldA landmark conference on "Feminism and Classics: Framing the Research Agenda" was held at Princeton University on November 7-10, 1996; the coorganizers were Janet M. Martin (Princeton University) and Judith P. Hallett (University of Maryland). This conference is the second in a series of more-or-less triennial meetings devoted to feminist research in various areas of classical studies. The first of these conferences (...) ("Feminism and Classics I") was held at the University of Cincinnati in 1992 and was codirected by Kathryn J. Gutzwiller and Ann N. Michelini (both of the University of Cincinnati; for a review of this conference see Clara Hardy and Kirk Ormand, BMCR 4.2 [1993] 135-41).The goals of the Princeton conference were several:mdash To address the evidential deficiencies of the traditional classical literary canon-by examining new kinds of sources and evidence, particularly nonliterary texts and material culture; and by giving increased attention to the ancient Near East and Africa (especially Egypt) as well as to post-classical Greek and Latin texts;mdash To address the methodological inadequacies of traditional historical and philological approaches-by applying the new literary and textual criticism and theory to the traditional classical literary canon as well as to nonliterary and postclassical texts; by adopting comparative approaches to the study of ancient sexuality and gender; and by considering women (in addition to men) as agents in the transmission of the classical tradition;mdash To clarify, illuminate, and evaluate the relations between classical scholarship and the politics of social change-by defining the actual and potential relations among feminist studies, gender studies, and women's studies, and the relation of classical studies to each; by examining the variety of relations that feminist and other scholarship can have to the politics of social change; and by addressing the role of theory in feminist scholarship in classics.The conference was divided into four plenary sessions, each one devoted to a core area of feminist scholarly research in classics: The Historical Recovery of Ancient Women (Speakers: Shelby Brown, UCLA [End Page 328] and Alan Shapiro, University of Canterbury, New Zealand; Discussants: Barry S. Strauss, Cornell University and Sandra R. Joshel, New England Conservatory of Music); Women and the Classical Tradition (Speakers: Joan M. Ferrante, Columbia University and Shelley P. Haley, Hamilton College; Discussants: Diana Robin, University of New Mexico and Judith P. Hallett, University of Maryland); Feminist Literary Studies and the Construction of Sexuality and Gender in the Ancient World (Speakers: David Konstan, Brown University and Barbara K. Gold, Hamilton College; Discussants: Ellen Oliensis, Yale University and Ruth Webb, Princeton University); Feminism and Classics in the Next Century: Feminist Studies, Gender Studies, Women's Studies (Speakers: Peter W. Rose, Miami University of Ohio and Nancy F. Partner, McGill University; Discussants: Sarah B. Pomeroy, Hunter College and CUNY and Amy Richlin, University of Southern California).In addition to the four plenary sessions, there was a rich variety of discussion and presentation in other formats: opening and closing roundtables (including, in addition to some of the speakers and organizers, Nancy Sorkin Rabinowitz, Hamilton College, Barbara M. McManus, College of New Rochelle, Bella Zweig, University of Arizona, Kathryn J. Gutzwiller, and Ann N. Michelini, both of the University of Cincinnati); the keynote address by Ernestine Friedl, Duke University; and sixteen interactive workshops, which followed up on the topics of the plenary sessions. These covered topics as broad as "Reading Gender in Epigraphical Text and Context" (Susan Guettel Cole), "The Classical World in Twentieth-Century Historical Fiction by Women" (Sheila Murnaghan and Deborah H. Roberts), "Feminist Theory/Queer Theory" (Kirk Ormand and Rabinowitz), "Politics, Pedagogy, and the Future of Gender Studies" (Mary Whitlock Blundell, Jeffrey S. Carnes, and John T. Kirby), and "Feminist Anthropology and Feminist Work in Classics" (Deborah Lyons).The conference was one of several events celebrating the 250th anniversary of Princeton University. In certain respects it carried on the work of the 1917 Princeton conference organized by Dean Andrew Fleming West. Entitled "Value of the Classics," the 1917 conference was also in its own way interdisciplinary, documenting the impact of classics on such fields as medicine, law, economics, sociology, and public... (shrink)

[Open access] In this book symposium the author takes up questions from phenomenology, hermeneutics, ethical theory, and intellectual history raised by a group of scholarly interlocutors from a range of backgrounds. In the course of engaging with these issues, he discusses, inter alia, McDowell’s realism, Jonathon Lear’s work on the end of a world, Michael Oakeshott’s view of selfhood, Heidegger’s conception of Jemeinigkeit, Uexküll’s notion of Umwelt, and Gadamer’s hermeneutic conception of truth.

David Hume's writings on history, politics and philosophy have shaped thought to this day. His bold scepticism ranged from common notions of the 'self' to criticism of standard theistic proofs. He insisted on grounding understandings of popular religious beliefs in human psychology rather than divine revelation, and he aimed to disentangle philosophy from religion in order to allow the former to pursue its own ends. In this book, Professors David W Purdie and Peter S Fosl decipher some of (...) Hume's most challenging texts for the modern reader, while preserving the sharp intellect and undaunted nerve for which Hume is famous. Hume's spirit is brought alive for contemporary times and his writing is made accessible for its intended audience: the general public."-- Back cover. (shrink)

Originally published in 1957, the primary aim of this study was to shed light upon the logical character of the psychology of perception. D.W. Hamlyn begins by delimiting the field of psychological inquiry into perception, then gives a detailed account of the types of explanation appropriate in the field. He maintains that these explanations have certain important peculiarities which distinguish them from other scientific inquiries. In view of the central importance of Gestalt Theory in this field an account is given (...) of its origins, and its main features are critically discussed. The work should still be of considerable interest to both philosophers and psychologists, as well as to all those interested in the relations between the two subjects. (shrink)

Despite the importance of linguistic disclosure for philosophical hermeneutics there has been a conspicuous lack of attention to the question of how linguistic disclosure actually works. I examine the mechanics of disclosure by drawing on Gadamer’s philosophical hermeneutics as well as Ricoeur’s concept of translation and his theory of metaphor. My claim is that the background horizon of the unsaid that differs between languages enables each to disclose different things. This situation underscores the importance of engaging in East-West comparative philosophy, (...) of philosophizing across what Ricoeur calls the radical “fold” (pli) in what can be thought and experienced. (shrink)

This paper attempts to reconcile two ideas that seem fundamentally opposed to one another: the reality of the self and the doctrine of no-self. Buddhism offers a form of spiritual equanimity that turns on the denial of a self. Nonetheless, there seem to be good reasons to hold onto the reality of the self. The existence of a self enables us to account for praise and blame, the hopes for oneself that motivate actions, and attachments to the selves of others (...) in bonds of love and affection. I show how it may be possible to reconcile the reality of the self with a particular interpretation of the no-self doctrine by engaging with the work of thinkers from the phenomenological tradition such as Merleau-Ponty, Zahavi, Gallagher, and Petitmengin. (shrink)

While a number of classical pragmatists crafted their philosophies in conjunction with a careful study of Hegel's works, others saw their philosophies emerge in antagonism with proponents of Hegel. In this paper, we offer an instance of the latter case. Namely, we show that the impetus for Charles S. Peirce's early articulation and avowal of realism (the claim that some generals are real) was William Torrey Harris's claim that the formal laws of logic lacked universal validity. According to Harris, the (...) leading representative of Hegelism in the United States, the universal validity of the laws of logic rested on a nominalistic metaphysics that a Hegelian-realism showed to be false. In response to this charge, we articulate how Peirce's attempt to prove the universal validity of the laws of logic resulted in avowing a realism that differed from both nominalism and Harris's Hegelian-realism. (shrink)

Since the advent in the early thirties of logical positivism much attention has been focused upon the nature of ethics.

Some philosophers have argued recently that the content of perception is either entirely or mainly non- conceptual. Much of the motivation for that view derives from theories of information processing, which are a modern version of ancient considerations about the causal processes underlying perception. The paper argues to the contrary that perception is essentially concept- dependent. While perception must have a structure derived from what is purely sensory, and is thereby dependent on processes involving information in the technical sense which (...) Gibson said amounted to structure, the information which perception provides about the world depends on the concepts which we have. (shrink)

This essay explains how reading philosophy is different from other forms of academic reading and provides guidance for reading well to people who are new to the field.

In this article, I respond to David McIvor’s and Lars Rensmann’s discussion of my recent book, The Politics of Repressed Guilt: The Tragedy of Austrian Silence (2018, Edinburgh University Press). Both invited me to clarify my use of Arendt in my conception of embodied reflective judgment. I argue for a stronger connection between judgment and emotions than Arendt because one can effectively shut down critical thinking if one uses defense mechanisms to repress feelings of guilt. In response to McIvor, (...) I discuss the idea of the “subject-in-outline” and “embodied reflective spaces” to overcome the guilt/defense complex to engender a reparative politics of justice. Finally, in response to Rensmann, I point out that the lingering culture of repressed guilt helps us explain the general conditions that contributed to the rise of the far and extremist right in Austria, which I develop further in my new book Analyzing the Far Right. (shrink)

This paper articulates and defends a noncognitive, care-based view of identification, of what privileged psychic subset provides the source of self-determination in actions and attitudes. The author provides an extended analysis of "caring," and then applies it to debates between Frankfurtians, on the one hand, and Watsonians, on the other, about the nature of identification, then defends the view against objections.

Fichte-Studien 49 (2021), edited by David W. Wood, published by Brill/Rodopi, 471pp. -/- Presenting new critical perspectives on J.G. Fichte’s Wissenschaftslehre, this volume of articles in English by an international group of scholars addresses the topic of first principles in Fichte’s writings. Especially discussed are the central text of his Jena period, the 1794/95 Grundlage der gesammten Wissenschaftslehre, as well as later versions like the Wissenschaftslehre nova methodo (1796-99) and the presentations of 1804 and 1805. Also included are new (...) studies on the first principles of the particular sub-disciplines of Fichte’s system, such as the doctrines of aesthetics, nature, right, ethics, and history. The volume also contains a number of miscellaneous essays on Fichte research, as well as several book reviews. (shrink)

David Miller is the foremost exponent of the purist critical rationalist doctrine and here presents his mature views, discussing the role that logic and argument play in the growth of knowledge, criticizing the common understanding of argument as an instrument of justification, persuasion or discovery and instead advocating the critical rationalist view that only criticism matters. Miller patiently and thoroughly undoes the damage done by those writers who attack critical rationalism by invoking the sterile mythology of induction and justification (...) that it seeks to sweep away. In addition his new material on the debate on verisimilitude is essential reading for all working in this field. (shrink)

In lieu of an abstract, here is the first paragraph: Paksi and Héder’s Guide to Personal Knowledge (hereafter GPK and Guide) is, as the title suggests, a guide of the most important and original ideas of Michael Polanyi’s book Personal Knowledge: Towards a Post-Critical Philosophy (1958, hereafter PK). Is a guide to Personal Knowledge needed? I think the answer is a resounding “yes” for many new readers. To see why, let’s briefly review two common complaints about PK.

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity (...) to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)

This paper focuses on one of the mainstays of Japanese psychiatrist and philosopher Kimura Bin’s (1931–2021) philosophical approach. Kimura’s work is characterized by the intersection of therapeutic, philosophical, and intercultural dimensions in ways that enable his clinical practice and philosophical investigations to mutually inform one another. I examine how this dialectic comes together with his conversion of ordinary Japanese words into philosophical concepts. Explicating the concepts Kimura deploys in developing a phenomenology of the self allows us to make new sense (...) of phenomena ranging from the process of individuation to the collective subjectivity of group life, from the breakdown of the self to its fuller realization. (shrink)

This paper defends the permissibility of stem cell research against a theological objector who objects to it by appealing to "souls.".

Despite claims that STS science education promotes ethical responsibility, this approach is not supported by a clear philosophy of ethics. This paper argues that the work of Emmanuel Levinas provides an ethics suitable for an STS science education. His concept of the face of the Other redefines education as learning from the other, rather than about the other. Extrapolating the face of the Other to the non‐human world suggests an ethics for science education where the goal of pedagogy is peace (...) with each other and the world through the rupture, eros and justice that arises from openness to the demands of the world. Understanding the infinite responsibility of the invocation presented by the face of the Other radically reconceptualizes science education from STS towards an E‐STS curriculum of responsiveness that critically employs the said of modern science and opportunities of experience to enable the next generation of citizens to act in peace to what the world is saying. (shrink)

David Miller elegantly and provocatively reformulates critical rationalism—the revolutionary approach to epistemology advocated by Karl Popper—by answering its most important critics. He argues for an approach to rationality freed from the debilitating authoritarian dependence on reasons and justification. "Miller presents a particularly useful and stimulating account of critical rationalism. His work is both interesting and controversial... of interest to anyone with concerns in epistemology or the philosophy of science." —Canadian Philosophical Reviews.

Attacks nothing less than the currently prevailing worldphilosophy--humanism, which the author feels is exceedingly dangerous in itshidden assumptions.

This is a review essay in English of Dietrich von Engelhardt’s new 2,000-page, four-volume project: 'Medizin in Romantik und Idealismus: Gesundheit und Krankheit in Leib und Seele, Natur und Kultur' (Medicine in Romanticism and Idealism: Health and Illness in Body and Soul, Nature and Culture). (Stuttgart-Bad Cannstatt: frommann-holzboog, 2023), 4 Vols., LII + 1964 pp.

The search for increased productivity has led to a great many claims about how it might be accomplished. Nowhere have the claims been more brazen and yet less well supported empirically than those made on behalf of the technologies designed to support office work. The paper examines some of the arguments and claims made, suggesting that most of them are off target. While the new technologies may be of substantial value, the emphasis should beon increased effectiveness, not on greater efficiency. (...) Only then are the visions of the future likely to be fulfilled. (shrink)

It has been suggested that we turn to solar geoengineering to counter global warming, which would consequently transform the relationship of terrestrial plant-life to the sun. This is an article not about geoengineering as such, but instead what is called photosynethics, or, thinking about our moral relationship to the light – in particular, as it is mediated by plants. Working from within but then extending the idea of responsibility found in the work of Emmanuel Levinas, it is argued here that, (...) since the plant cultivates the conditions of life on earth by photosynthesis, its relationship to the sun is then a relation of giving to others that is properly moral. The plant’s existence is an exposure so out of kilter with human ways of understanding existence that it interrupts our own and brings us into a relation of responsibility. It is concluded that rather than redirecting the sun’s radiation, we should turn to plants to reconsider how we live with the light on a heating planet. This first means separating moral responsibility from human vision so that we might encounter light on its own terms, and not simply as an element of rationality or sentiment or discipline. (shrink)

Processes governing the creation, perception and production of spoken words are sensitive to the patterns of speech sounds in the language user’s lexicon. Generative linguistic theory suggests that listeners infer constraints on possible sound patterning from the lexicon and apply these constraints to all aspects of word use. In contrast, emergentist accounts suggest that these phonotactic constraints are a product of interactive associative mapping with items in the lexicon. To determine the degree to which phonotactic constraints are lexically mediated, we (...) observed the effects of learning new words that violate English phonotactic constraints on phonotactic perceptual repair processes in nonword consonant-consonant-vowel stimuli. Subjects who learned such words were less likely to “repair” illegal onset clusters and report them as legal ones. Effective connectivity analyses of MRI-constrained reconstructions of simultaneously collected magnetoencephalography and EEG data showed that these behavioral shifts were accompanied by changes in the strength of influences of lexical areas on acoustic-phonetic areas. These results strengthen the interpretation of previous results suggesting that phonotactic constraints on perception are produced by top-down lexical influences on speech processing. (shrink)

Unabridged dictionaries are dangerous books. In their pages man’s evilest thoughts find means of expression. Terms denoting all that is foul or blasphemous or obscene are printed there for men, women and children to read and ponder. Such books should have their covers padlocked and be chained to reading desks, in the custody of responsible librarians, preferably church members in good standing. Permission to open such books should be granted only after careful inquiry as to which word a reader plans (...) to look up, and how he plans to use it. (shrink)

The main question that Firestone & Scholl (F&S) pose is whether “what and how we see is functionally independent from what and how we think, know, desire, act, and so forth” (sect. 2, para. 1). We synthesize a collection of concerns from an interdisciplinary set of coauthors regarding F&S's assumptions and appeals to intuition, resulting in their treatment of visual perception as context-free.

Derek Parfit claims that, at certain times and places, the metaphysical units he labels *'selves" may be thought of as the morally significant units (I.e., the objects of moral concern) for such things as resource distribution, moral responsibility, commitments, etc. But his concept of the self is problematic in important respects, and it remains unclear just why and how this entity should count as a moral unit in the first place. In developing a view I call *'Moderate Reductionism," I attempt (...) to resolve these worries, first by offering a clearer, more consistent account of what the concept of *'self ' should involve, and second by arguing for why selves should indeed be viewed as moral (and prudential) units. I then defend this view in detail from both *'conservative" and *'extreme" objections. (shrink)

In birds and frogs, species pairs retain the capacity to produce viable hybrids for tens of millions of years, an order of magnitude longer than mammals. What accounts for these differences in relative rates of pre- and postzygotic isolation? We propose that reproductive mode is a critically important but previously overlooked factor in the speciation process. Viviparity creates a post-fertilization arena for genomic conflicts absent in egg-laying species. With viviparity, conflict can arise between: mothers and embryos; sibling embryos in the (...) womb, and maternal and paternal genomes within individual embryos. Such intra- and intergenomic conflicts result in perpetual antagonistic coevolution, thereby accelerating interpopulation postzygotic isolation. In addition, by generating intrapopulation genetic incompatibility, viviparity-driven conflict favors polyandry and limits the potential for precopulatory divergence. Mammalian diversification is characterized by rapid evolution of incompatible feto-maternal interactions, asymmetrical postzygotic isolation, disproportionate effects of genomically-imprinted genes, and “F2 hybrid enhancement.” The viviparity-driven conflict hypothesis provides a parsimonious explanation for these patterns in mammalian evolution. BioEssays 22:938–946, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

"FICHTEANA Review of J.G. Fichte Research" is an online publication in English devoted to new scholarship on the philosopher Johann Gottlieb Fichte. It publishes information and reviews of the latest Fichte editions, books, publications, conferences, and Calls for Papers. Originally founded by Daniel Breazeale in 1993, since issue 22 (2022), FICHTEANA has appeared in an expanded form with book reviews. It is co-edited by Daniel Breazeale and David W. Wood, with associate editor Kienhow Goh. -/- .

The emergence and scope of personal and collective efforts to integrate faith into workplaces is a social movement that includes and extends beyond personal ethics. This paper discusses the development of The Integration Profile Faith and Work Integration Scale, which is designed to measure the multidimensional nature of faith expressions within workplace settings. TIP measures the manifestations of faith, religion, and spirituality at the individual level. Earlier research theorized that individuals tend to manifest or live out their faith in one (...) of four ways ; TIP expands this to assess eight sub-orientations, nested within the four main manifestations of faith–work integration. The development of the 24-item TIP scale involved exploratory analyses in a sample of 512 employees of a for-profit palliative care organization and a hierarchical confirmatory factor analysis in a sample of 4463 employees in an American multinational food processing organization. Additional analyses were conducted in a third sample of 266 working adults to assess the convergent and discriminant validity of the eight sub-orientations with other faith variables as well as associations with work outcomes. (shrink)