The objective of the current study was to propose a sensitivity analysis of a 3D left ventricle model in order to assess the influence of parameters on myocardial mechanical dispersion. A finite element model of LV electro-mechanical activity was proposed and a screening method was used to evaluate the sensitivity of model parameters on the standard deviation of time to peak strain. Results highlight the importance of propagation parameters associated with septal and lateral segments activation. Simulated curves were compared to (...) myocardial strains, obtained from echocardiography of one healthy subject and one patient diagnosed with intraventricular dyssynchrony and coronary artery disease. Results show a close match between simulation and clinical strains and illustrate the model ability to reproduce myocardial strains in the context of intraventricular dyssynchrony. (shrink)

Here the philosopher and physicist David Z Albert argues, among other things, that the difference between past and future can be understood as a mechanical phenomenon of nature and that quantum mechanics makes it impossible to present the entirety of what can be said about the world as a narrative of “befores” and “afters.”.

"An admirable accomplishment.... Roberts provides valuable insights into the current debate on the nature of historical knowledge in our present 'postmodern' time. Anyone concerned with the philosophy of history will need to reckon with this book."--Allan D. Megill, author of "Prophets of Extremity".

In _The Later Middle Ages,_ the third volume of his monumental _History of Political Ideas,_ Eric Voegelin continues his exploration of one of the most crucial periods in the history of political thought. Illuminating the great figures of the high Middle Ages, Voegelin traces the historical momentum of our modern world in the core evocative symbols that constituted medieval civilization. These symbols revolved around the enduring aspiration for the _sacrum imperium,_ the one order capable of embracing the transcendent and immanent, (...) the ecclesiastical and political, the divine and human. The story of the later Middle Ages is that of the "civilizational schism"—the movement in which not only the reality but the aspiration for the _sacrum imperium_ gradually disappeared and the unification of faith and reason dissolved. His recognition of this civilizational schism provides Voegelin with a unique perspective on medieval society. William of Ockham, Dante, Giles of Rome, and Marsilius of Padua all emerge in Voegelin's study as predecessors to modern thought; each turns to personal authority and intellectual analysis in an attempt to comprehend the loss of the _sacrum imperium_ as an authoritative ideal. Voegelin is further drawn into investigations that, despite insufficient attention by scholars, still bear relevance to the study of the later Middle Ages. The mysticism apparent in _Piers Plowman_ and the apocalyptic revolt of Cola di Rienzo are merely two reactions to the disintegration of wholeness. Yet the story of the later Middle Ages does not merely revolve around disintegration. Voegelin recognizes the emergence of the constitutional political tradition as the most positive development of this period. He is at his best when explaining the difference between the presence of a representative institution and the growth of communal consciousness. Voegelin's study of the English political pattern is matched only by his unique perspective on the German imperial zone, culminating in a fitting conclusion on Nicholas of Cusa—the one political thinker with the ability to evoke the unity of mankind beyond fragmentation. _The Later Middle Ages_ is at once a brilliant examination of the symbols that characterized medieval society and a remarkable predecessor to Voegelin's study of the modern world, beginning with the Renaissance and the Reformation. (shrink)

The prelims comprise: Introduction How it Works Sources of Error and Uncertainty DNA Typing Results as Legal Evidence The Legal Reception of DNA Typing DNA Typing and the Judicial Assessment of Scientific Evidence Social Impact: Criminal Investigation and Adjudication Conclusion Notes.

The shape and turnover of photoreceptor membranes appears to depend on associated actin filaments. In dipterans, the photoreceptor membrane is microvillar. It is turned over by the addition of new membrane at the bases of the microvilli and by subsequent shedding, mostly from the distal ends. Each microvillus contains actin filaments as a component of its cytoskeletal core. Two myosin I‐like proteins co‐localize with the actin filaments. It is suggested that one of the myosin I‐like proteins might be linked to (...) the microvillar membrane. By interacting with the actin filaments, this motor should move the membrane of a microvillus in a distal direction, thus providing a possible mechanism for the turnover of the membrane.A vertebrate photoreceptor cell contains a small cluster of actin filaments in its connecting cilium at the site where new transductive disk membranes are formed. Disruption of the actin filaments perturbs disk morphogenesis. The most likely explanation for this perturbation is that the process of initiating a new disk is inhibited. Conventional myosin (myosin II) is found in the connecting cilium with the same distribution as actin. A simple model is proposed to illustrate how the actin–myosin system of the connecting cilium might function to initiate the morphogenesis of a disk membrane. (shrink)

Habit rules our lives. While many of our individual habits seem perfectly reasonable, when aggregated together they spell ecological disaster. Beyond consumerism, other ways of living are clearly possible. Reoccupy Earth shows how an approach to philosophy attuned to our ecological existence can suspend the taken-for-granted and open up alternative forms of earthly dwelling.

David Alexander has argued that “weak inferential internalism” (WII), a position which amounts to a qualified endorsement of Richard Fumerton’s controversial “principle of inferential justification,” is subject to a fatal dilemma: Either it collapses into externalism or it must make an arbitrary epistemic distinction between persons who believe the same proposition for the same reasons. In this paper, I argue that the dilemma is a false one, for weak inferential internalism does not entail internalism simpliciter. Indeed, WII is compatible (...) with modest externalism, and so is consistent with what Armstrong calls “Type II justification,” the rejection of which leads to the arbitrary epistemic distinctions to which he rightly objects. (shrink)

Classical Arabic Begging Poetry and Šakwā, 8th–12th Centuries. By Nefeli Papoutsakis. Arabische Studien, vol. 14. Wiesbaden: Harrassowitz, 2017. Pp. viii + 254. €58.

According to Donald Davidson and other philosophers who wish to avoid what Sellars called the Myth of the Given (like Brandom and Rorty), the relation between the deliverances of our senses and our conceptual capacities is not foundational (justificatory), but merely causal. In Mind and World, John McDowell criticizes Davidson for this view and maintains that this kind of coherentism makes it impossible to understand the intentionality of thought and language. However, many critics have complained that they cannot find an (...) argument for this claim in Mind and World. This paper (in German) aims to reconstruct such an argument out of McDowellian materials laid out in a series of critical articles devoted to Brandom's version of the coherentist picture. (shrink)

In this paper I discuss the managerial template that has become the normative model for the organization of the university. In the first part of the paper I explain the corporatization of academic life in terms of the functional relationships that make up the organizational components of the commercial enterprise and their inappropriateness for the life of the academy. Although there is at present a significant body of literature devoted to this issue, the goal of this paper is to explain (...) the genesis of this phenomenon through a reference to the ideology that characterizes our modern secular age. This is the subject of the second part of the paper. Most texts seek to explain this ideological development either through the ever increasing dominance of economic rationalism, perceived conservatism of collegial forms of governance, the necessity to transfer fiscal responsibility in tight budgetary periods, the decline of the Keynesian ‘welfare consensus’, or the legacy of the power regimes that began to take shape in the liberal societies of the 19th century. I trace this development to the beginnings of Modernity and the Cartesian bifurcation that separated the material world from its spiritual and intellectual source and thereby overthrew the hierarchy of related values that informed both nature and human organization. In articulating this argument I make reference to the thought of Jacques Maritain, Charles Taylor and René Guénon. (shrink)

This article seeks to integrate the roles of structure and human agency in a theory of historical causation, using the fall of the Weimar Republic and in particular Henry Turner's book Hitler's Thirty Days to Power as a case study. Drawing on analogies from chaos theory, it argues that crisis situations in history exhibit sensitive dependence on local conditions, which are always changing. This undermines the distinction between causes and conditions . It urges instead a distinction between empowering and constraining (...) causes of specific human actions as a more fruitful model. The paper also discusses more briefly two other analogies to chaos theory: 1) similarity across differences in scale as applicable to different levels of individual and collective events, which are seen as homologous; 2) a model of branching as applicable to the totality of causes of a given event. (shrink)

Do “majestic Christologies” violate the principle of non-competitive relationship? Majestic Christologies are diverse according to conceptual delineation, but share the common affirmation that Jesus’ humanity participates in the divine majesty in a transformative manner. This notion seems to transgress the principle of non-competitive relationship by behaving as if the fullness of Christ’s deity requires a displacement or transmogrification of his creatureliness. This paper argues that majestic Christology does not necessarily contradict the non-competitive principle by emphasizing the elasticity of theological anthropology (...) from an eschatological point of view. (shrink)

Threat avoidance involves both detection of a threatening stimulus and reaction to it. We demonstrate with empirically validated stimuli that threat detection is more pronounced among males, whereas threat reactivity is more pronounced among females. Why women are less efficient detectors of threat challenges Benenson et al.'s conceptual analysis.

Journal Name: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Volume: 2013 Issue: 196 Pages: 423-429.

We present a theoretical framework of individual-decision making that incorporates both moral motivations and social influence into the utility function. The main idea of the paper is that individuals face a trade-off between their material individual interests and their desire to follow moral obligation. In our model, we assume that moral motivation is weak or conditional in the sense that it may be influenced by others’ actions. Specifically, in our framework one’s moral obligation is a combination of two main components: (...) an autonomous component and a social component that captures the influence of others. Our theoretical framework is able to explain many stylized results commonly observed in the literature and suggests a different mechanism to explain economic behavior. (shrink)

An encounter with a large object may induce feelings of fear, awe, attraction, and more. But it is not simply the physical dimensions of an object that account for our sense that something is "big." Big Culture is a study of large objects and images that works to identify the qualities and effects of bigness. In doing so, David Wittenberg offers a philosophical proposal for reconceptualizing the problem of magnitude. The book explores examples of bigness that are simultaneously familiar (...) and singular in the cultural landscape, such as skyscrapers, atomic bomb explosions, and cinematic special effects. From these examples, Wittenberg postulates a new aesthetics of magnitude that is better able to account for the special role that bigness plays in our everyday perception of objects and images. Big Culture argues that bigness is a more primal, a more absolute, and even a more violent or erotic encounter with the objective world than the scalar relativism that tends to characterize our lives. Ultimately, Wittenberg insists that bigness comes before scale, even before size itself. (shrink)