Clonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCR‐ABL, characteristic of chronic myeloid leukemia; mutations of the PIG‐A gene, characteristic of paroxysmal nocturnal hemoglobinuria; the V617F mutation in the JAK2 gene, characteristic of myeloproliferative diseases. The population frequencies of these three blood (...) disorders fit well with a hierarchical model of hematopoiesis. The fate of any mutant clone will depend on the target cell and on the fitness advantage, if any, that the mutation confers on the cell. In general, we can expect that only a mutation in a hematopoietic stem cell will give long‐term disease; the same mutation taking place in a cell located more downstream may produce just a ripple in the hematopoietic ocean. (shrink)

This work is for scholars, researchers and students in history and philosophy of science focusing on Logical Empiricism and analytic philosophy (of science). It provides historical and systematic research and deals with the influence and impact of the Vienna Circle/Logical Empiricism on today's philosophy of science. It also explores the intellectual context of this scientific philosophy and focuses on main figures and peripheral adherents.

This article presents results from a multidisciplinary research project on the integration and transfer of language knowledge into robots as an empirical paradigm for the study of language development in both humans and humanoid robots. Within the framework of human linguistic and cognitive development, we focus on how three central types of learning interact and co-develop: individual learning about one's own embodiment and the environment, social learning (learning from others), and learning of linguistic capability. Our primary concern is how these (...) capabilities can scaffold each other's development in a continuous feedback cycle as their interactions yield increasingly sophisticated competencies in the agent's capacity to interact with others and manipulate its world. Experimental results are summarized in relation to milestones in human linguistic and cognitive development and show that the mutual scaffolding of social learning, individual learning, and linguistic capabilities creates the context, conditions, and requisites for learning in each domain. Challenges and insights identified as a result of this research program are discussed with regard to possible and actual contributions to cognitive science and language ontogeny. In conclusion, directions for future work are suggested that continue to develop this approach toward an integrated framework for understanding these mutually scaffolding processes as a basis for language development in humans and robots. (shrink)

This is the compelling story of one of the most fascinating thinkers of the twentieth century- a richly toned portrait of a modern-day Thoreau.

Ecology, Community and Lifestyle is a revised and expanded translation of Naess' book Okologi, Samfunn og Livsstil, which sets out the author's thinking on the relevance of philosophy to the problems of environmental degradation and the rethinking of the relationship between mankind and nature. The text has been thoroughly updated by Naess and revised and translated by David Rothenberg.

"At places distant from where you are, but also uncomfortably close," writes David Takacs, "a holocaust is under way. People are slashing, hacking, bulldozing, burning, poisoning, and otherwise destroying huge swaths of life on Earth at a furious pace." And a cadre of ecologists and conservation biologists has responded, vigorously promoting a new definition of nature: biodiversity --advocating it in Congress and on the Tonight Show; whispering it into the ears of foreign leaders redefining the boundaries of science and (...) politics, ethics and religion, nature and our ideas of nature. These scientists have infused the environmental movement with new focus and direction, but by engaging in such activities, they jeopardize the societal trust that allows them to be public spokespersons for nature in the first place. The Idea of Biodiversity analyzes what biodiversity represents to the biologists who operate in broader society on its behalf, drawing on in-depth interviews with the scientists most active today in the mission to preserve biodiversity, including Peter Raven, Thomas Lovejoy, Jane Lubchenco, and Paul Ehrlich. Takacs explores how and why these biologists shaped the concept of biodiversity and promoted it to society at large--examining their definitions of biodiversity their opinions about spirituality and its role in scientific work the notion of biodiversity as something of intrinsic value and their views on biophilia, E. O. Wilson's idea that humans are genetically predisposed to love nature. Takacs also looks at the work of twentieth-century forerunners of today's conservation biologists--Aldo Leopold, Charles S. Elton, Rachel Carson, David Ehrenfeld--and points out their contributions to the current debates. He takes readers to Costa Rica, where a group of scientists is using biodiversity to remake nature and society. And in an extended section, he profiles the thoughts and work of E. O. Wilson. "When I'm asked, 'should we save this species orthat species, or this place or that place?' the answer is always 'Yes!' with an exclamation point. Because it's obvious. And if you ask me to justify it, then I switch into a more cognitive consciousness and can start giving you reasons, economic reasons, aesthetic reasons. They're all dualistic, in a sense. But the feeling that underlies it is that 'yes!' And that 'yes!' comes out of the affirmation of being part of it all, being part of this whole evolutionary process. And agreeing with Arne Naess that each species, each entity, should be allowed to continue its evolution and to live out its destiny... just do its thing, as we say. Why not? And the 'why not?' is there's too many people."--Michael E. Soule, from an interview in The Idea of Biodiversity "An important contribution, a first distanced examination of a critical, modern topic by a scholarly, honest broker."--E. O. Wilson, Harvard University. (shrink)

"Wisdom in the Open Air" traces the Norwegian roots of the strain of thinking called "deep ecology" - the search for the solutions to environmental problems by examining the fundamental tenets of our culture. Although Arne Naess coined the term in the 1970s, the insights of deep ecology actually reflect a whole tradition of thought that can be seen in the history of Norwegian culture, from ancient mountain myths to the radical ecoactivism of today. Beginning with an introduction to Norway's (...) emphasis on nature and the wild, Reed and Rothenberg explore the birth of the environmental movement in the 1960s and 1970s. What follows is a collection of writings by prominent Norwegian thinkers on humanity and nature, most never before published in English. From Peter Wessel Zapffe, a twentieth-century Kierkegaardian figure, the list goes on to include Arne Naess, activist/critic/artist Sigmund Kvaloy, wilderness educator Nils Faarlund, novelist Finn Alnaes, sociologist Johan Galtung, and social reformer Erik Dammann. Their points of view offer thoughts on the significance of modern life and what it means to be human in the face of deteriorating environmental global trends of the 20th century. "Wisdom in the Open Air" asks and answers a fundamental question concerning the ecomovement: what is the role of deep, often abstract, thinking in the attempt to avert a very real ecological crisis? (shrink)

Arne Naess introduced the notion of ?concrete contents? to posit that the qualities we perceive in nature are intrinsic to the things themselves, and not just projections of our senses on to the world. This gives environmentalism more credence than if secondary qualities about the environment are considered subjective in a pejorative sense. But the concrete contents position pushes philosophy toward poetry because it suggests that felt qualities are as primary as logic. For a philosophy to justify itself, it sometimes (...) needs to find resonance with qualities outside its borders. Examples are presented from Italian writer Italo Calvino, the music of the Kahuli people of New Guinea, a film by John Sayles, and a poem by Tomas Tranströmer. The concrete philosophical contents of the world are found in the relationships between philosophy and experience, never inside philosophy alone. (shrink)

The global pandemic has pushed many of us to online streaming services. A particular genre in these services is the ‘end of the world’ science fiction film, in and through which the speculated results of processes such as climate change are depicted. CGI technology is frequently deployed to create images of the end of the world, which is a backdrop to the narrative of, ‘saving ourselves amidst the ruins’. This philosophy of education essay will critically examine ten films in order (...) to:Explain how ‘the end of the world’ images connected to processes such as climate change, obscures and displaces attention from the real, scientifically proven processes that are not so entertaining, but are still deadly. The images are created by capital and its machines for audience attention and have little to do with real social change. Science sits in an ambiguous position in this paper in that the real processes of climate change proven by science may be funded by capitalist mechanisms that can also be their cause.Introduce a reformulated notion of ecosophy from the work of Félix Guattari, Murray Bookchin, Arne Næss and Andre Gorz. This essay will suggest that ecosophy has the potential to teach the underlying split between depictions of the end of the world through the capitalist machine and the real social change necessary under climate change. Ecosophy is in the context of this essay a specific conceptual construction designed for teaching about climate change through cinema. (shrink)

The philosophy of deep ecology originated in the 1970s with the Norwegian philosopher Arne Naess and has since spread around the world. Its basic premises are a belief in the intrinsic value of nonhuman nature, a belief that ecological principles should dictate human actions and moral evaluations, an emphasis on noninterference into natural processes, and a critique of materialism and technological progress.This book approaches deep ecology as a philosophy, not as a political, social, or environmental movement. In part I, the (...) authors compare deep ecology's philosophical ideas with other positions and debates in environmental philosophy and to other schools of thought such as social ecology, ecofeminism, and moral pluralism. In part II, they investigate the connections between deep ecology and other contemporary world views, such as continental philosophy, postmodernism, and non-Western philosophical traditions. The first anthology on deep ecology that is not primarily the work of the movement's followers, Beneath the Surface offers a rigorous assessment of deep ecology's strengths and weaknesses as a philosophical position.Contributors : John Clark, Deane Curtin, Arran Gare, William Grey, Mathew Humphrey, Knut Jacobsen, Eric Katz, Andrew Light, Jonathan Maskit, Val Plumwood, David Rothenberg, Ariel Salleh, Bron Taylor, Michael Zimmerman. (shrink)

David Abram est l’un des protagonistes les plus influents de la philosophie environnementale, aux confluents de l’écosophie d’Arne Næss et de l’ontologie de la chair de Maurice Merleau-Ponty. Cette brève contribution relève certains motifs et arguments centraux de la pensée d’Abram, en particulier son interprétation de la spécificité de l’animalité humaine et la perception du caractère animé du paysage. Elle ancre Abram dans une cosmologie animiste et donne une réponse à la question de la forme que pourrait prendre une (...) sagesse indigène contemporaine en Occident. (shrink)

This book is a systematic and constructive treatment of a number of traditional issues at the foundation of ethics, the possibility and nature of moral knowledge, the relationship between the moral point of view and a scientific or naturalistic world view, the nature of moral value and obligation, and the role of morality in a person's rational life plan. In striking contrast to many traditional authors and to other recent writers in the field, David Brink offers an integrated defense (...) of the objectivity of ethics. (shrink)

When philosophers address personal identity, they usually explore numerical identity: what are the criteria for a person's continuing existence? When non-philosophers address personal identity, they often have in mind narrative identity: Which characteristics of a particular person are salient to her self-conception? This book develops accounts of both senses of identity, arguing that both are normatively important, and is unique in its exploration of a range of issues in bioethics through the lens of identity. Defending a biological view of our (...) numerical identity and a framework for understanding narrative identity, DeGrazia investigates various issues for which considerations of identity prove critical: the definition of death; the authority of advance directives in cases of severe dementia; the use of enhancement technologies; prenatal genetic interventions; and certain types of reproductive choices. He demonstrates the power of personal identity theory to illuminate issues in bioethics as they bring philosophical theory to life. (shrink)

In an important departure from theories of causation, David Owens proposes that coincidences have no causes, and that a cause is something which ensures that its effects are no coincidence. In Causes and Coincidences, he elucidates the idea of a coincidence as an event which can be analysed into constituent events, the nomological antecedents of which are independent of each other. He also suggests that causal facts can be analysed in terms of non-causal facts, including relations of necessity. Thus, (...) causation is defined in terms of coincidence, and coincidence without reference to causation. David Owens challenges the ideas associated with Hume, Davidson and Lewis, constructing a theory which distinguishes nomological necessity and sufficiency from their logical counterparts. He is able to offer novel solutions to the major problems of causation, including the direction of causation, the logical form of causal statements, the distinction betwen causal connections and logical connections, and the relationship between psychological and physical causation. (shrink)

In this classic, David Bohm was the first to offer us his causal interpretation of the quantum theory. _Causality and Chance in Modern Physics_ continues to make possible further insight into the meaning of the quantum theory and to suggest ways of extending the theory into new directions.

A landmark work of western philosophy, "On the Genealogy of Morality" is a dazzling and brilliantly incisive attack on European "morality". Combining philosophical acuity with psychological insight in prose of remarkable rhetorical power, Nietzsche takes up the task of offering us reasons to engage in a re-evaluation of our values. In this book, David Owen offers a reflective and insightful analysis of Nietzsche's text. He provides an account of how Nietzsche comes to the project of the re-evaluation of values; (...) he shows how the development of Nietzsche's understanding of the requirements of this project lead him to acknowledge the need for the kind of investigation of "morality" that he terms "genealogy"; he elucidates the general structure and substantive arguments of Nietzsche's text, accounting for the rhetorical form of these arguments, and he debates the character of genealogy as a form of critical enquiry. Owen argues that there is a specific development of Nietzsche's work from his earlier "Daybreak" and that in "Genealogy of Morality", Nietzsche is developing a critique of modes of agency and that this constitutes the most fundamental aspect of his demand for a revaluation of values. The book is a distinctive and significant contribution to our understanding of Nietzsche's great text. (shrink)

One way to understand science is as a selection process. David Hull, one of the dominant figures in contemporary philosophy of science, sets out in this 2001 volume a general analysis of this selection process that applies equally to biological evolution, the reaction of the immune system to antigens, operant learning, and social and conceptual change in science. Hull aims to distinguish between those characteristics that are contingent features of selection and those that are essential. Science and Selection brings (...) together many of David Hull's most important essays on selection in one accessible volume. (shrink)

This is the second of David Pears's acclaimed two‐volume work on the development of Wittgenstein's philosophy, covering the Philosophical Investigations and other writings from 1929 onwards. Though more selective in its coverage than the first volume (it deals mainly with Wittgenstein's philosophy of psychology and the ego, the possibility of a private language and rule‐following), the book reveals with great clarity the style, method, and content of Wittgenstein's later thought. While this volume is independently comprehensible, Pears remains largely within (...) the structural framework of the first volume and uncovers thereby the general overall configuration and internal organization of Wittgenstein's thought. (shrink)

This volume offers a carefully argued, compelling theory of bioethics while eliciting practical implications for a wide array of issues including medical assistance-in-dying, the right to health care, abortion, animal research, and the definition of death. The authors' dual-value theory features mid-level principles, a distinctive model of moral status, a subjective account of well-being, and a cosmopolitan view of global justice. In addition to ethical theory, the book investigates the nature of harm and autonomous action, personal identity theory, and the (...) 'non-identity problem' associated with many procreative decisions. Readers new to particular topics will benefit from helpful introductions, specialists will appreciate in-depth theoretical explorations and a novel take on various practical issues, and all readers will benefit from the book's original synoptic vision of bioethics. This title is also available as Open Access on Cambridge Core. (shrink)

This title was first published in 2003. This book critically examines the moral and political status of the child by a consideration of three interrelated questions: What rights if any does the child have? What rights over and duties in respect of a child do parents have? What rights over and duties in respect of a child does the state have? David Archard adopts three areas for particular discussion on the practical implications of the general theoretical issues: education, child (...) protection policy, and the medical treatment of children. Providing a clear legal context and a sharper, contemporary discussion of the question of rights, this book presents a clear introduction to the key issues in the moral and political status of children. (shrink)

This book aims to reinvigorate discussions of moral arguments for God's existence.

In this article, we discuss critically some of the key themes in Max Deutsch’s excellent book, The Myth of the Intuitive. We focus in particular on the shortcomings of his historical analysis – a missed opportunity by our lights, on the claim that philosophers present arguments in support of the judgments elicited by thought experiments, and on the claim that experimental philosophy is only relevant for the methodology of philosophy if thought experiments elicit intuitions.

This article develops an account of local epistemic practices on the basis of case studies from ethnobiology. I argue that current debates about objectivity often stand in the way of a more adequate understanding of local knowledge and ethnobiological practices in general. While local knowledge about the biological world often meets criteria for objectivity in philosophy of science, general debates about the objectivity of local knowledge can also obscure their unique epistemic features. In modification of Ian Hacking’s suggestion to discuss (...) “ground level questions” instead of objectivity, I propose an account that focuses on both epistemic virtues and vices of local epistemic practices. (shrink)

Philosophers like Shoemaker and Burge argue that only self-conscious creatures can exercise rational control over their mental lives. In particular they urge that reflective rationality requires possession of the I-concept, the first person concept. These philosophers maintain that rational creatures like ourselves can exercise reflective control over belief as well as action. I agree that we have this sort of control over our actions and that practical freedom presupposes self-consciousness. But I deny that anything like this is true of belief.

An introduction to the philosophy of law, which offers a modern and critical appraisal of all the main issues and problems. This has become a very active area in the last ten years, and one on which philosophers, legal practitioners and theorists and social scientists have tended to converge. The more abstract questions about the nature of law and its relationship to social norms and moral standards are now seen to be directly relevant to more practical and indeed pressing questions (...) about the justification of punishment, civil disobedience, the enforcement of morality, and problems about justice, rights, welfare, and freedom. David Lyons is a shrewd, clear and systematic guide through this tangled area. The book presupposes no formal training in law or philosophy and is intended to serve as a textbook in a range of introductory courses. (shrink)

This, the 21st volume in the Library of Living Philosophers, is more than Sir Alfred Ayer's final word on the philosophical issues that preoccupied him for more than sixty years; the list of contributors is a roll-call of some of the greatest living figures in philosophy, each expertly addressing a key problem arising in Ayer's work. Most of the critical papers are answered directly and in detail by Sir Alfred-he completed his replies to 21 of the 24 papers before his (...) death. Contributors include: A. J. Ayer, Evandro Agazzi, James Campbell, David S. Clarke, Michael Dummett, Elizabeth Eames, John Foster, Dimitri Ginev, Paul Gochet, Martin Hollis, Ted Honderich, Tscha Hung, Peter Kivy, Arne Naess, D. J. O'Connor, Desiree Park, David Pears, Azarya Polikarov, Hilary Putnam, Francisco Miró, Quesada C., A. Anthony Quinton, Emanuele Riverso, Ernest Sosa, T. L. S. Sprigge, Barry Stroud, and David Wiggins. (shrink)

Presentists, who believe that only present objects exist, should accept a thisness ontology, since it can do considerable work in defence of presentism. In this paper, I propose a version of presentism that involves thisnesses of past and present entities and I argue this view solves important problems facing standard versions of presentism.

Using Kierkegaard's later religious writings as well as his earlier philosophical works, David Gouwens explores this philosopher's religious and theological thought, focusing on human nature, Christ, and Christian discipleship. He helps the reader approach Kierkegaard as someone who both analysed religion and sought to evoke religious dispositions in his readers. Gouwens discusses Kierkegaard's main concerns as a religious and, specifically, Christian thinker, and his treatment of religion using the dialectic of 'becoming Christian', and counters the interpretation of his religious (...) thought as privatistic and asocial. Gouwens appraises both the edifying discourses and the pseudonymous writings, including the particular problems posed by the latter. Between foundationalism and irrationalism, Kierkegaard's ideas are seen to anticipate the end of 'modernity', while standing at the centre of the Christian tradition. (shrink)

The orphaned son of an Anglican clergyman, David Hartley was originally destined for holy orders. Declining to subscribe to the Thirty-Nine Articles, he turned to medicine and science yet remained a religious believer. This, his most significant work, provides a rigorous analysis of human nature, blending philosophy, psychology and theology. First published in two volumes in 1749, Observations on Man is notable for being based on the doctrine of the association of ideas. It greatly influenced scientists, theologians, social reformers (...) and poets: Samuel Taylor Coleridge, who named his eldest son after Hartley, had his portrait painted while holding a copy. Volume 2 is particularly concerned with human morality and the duty and expectations of mankind. Here the author is keen to show that scientific observation is not necessarily in conflict with religious conviction. (shrink)

For this volume David Wiggins has selected and revised eleven of his essays in an area of metaphysics where his work has been particularly influential, and he has added a substantial introduction and one new unpublished essay. Among the subjects treated are substance, identity, persistence, persons, sortals, and artefacts.

Hume’s Science of Human Nature is an investigation of the philosophical commitments underlying Hume's methodology in pursuing what he calls ‘the science of human nature’. It argues that Hume understands scientific explanation as aiming at explaining the inductively-established universal regularities discovered in experience via an appeal to the nature of the substance underlying manifest phenomena. For years, scholars have taken Hume to employ a deliberately shallow and demonstrably untenable notion of scientific explanation. By contrast, Hume’s Science of Human Nature sets (...) out to update our understanding of Hume’s methodology by using a more sophisticated picture of science as a model. (shrink)

An expanded and updated edition of this classic collection.

Whether children have rights is a debate that in recent years has spilled over into all areas of public life. It has never been more topical than now as the assumed rights of parents over their children is challenged on an almost daily basis. David Archard offers the first serious and sustained philosophical examination of children and their rights. Archard reviews arguments for and against according children rights. He concludes that every child has at least the right to the (...) best possible upbringing. Denying that parents have any significant rights over their children, he is able to challenge current thinking about the proper roles of state and family in rearing children. Crucially, he considers the problem of how to define and understand `child abuse'. (shrink)

With respect to many, if not most issues, there exist significant differences of opinion among individuals who seem to be equally knowledgeable and sincere. Individuals who apparently have access to the same information and are equally interested in the truth affirm incompatible perspectives on, for instance, significant social, political, and economic issues. Such diversity of opinion, though, is nowhere more evident than in the area of religious thought. On almost every religious issue, honest, knowledgeable people hold significantly diverse, often incompatible (...) beliefs. -/- Religious diversity of this sort can fruitfully be explored in many ways — for instance, from psychological, anthropological, or historical perspectives. The current discussion, however, will concern itself primarily with those key issues surrounding religious diversity with which philosophers, especially analytic philosophers of religion, are most concerned at present. Specifically, our discussion will focus primarily on the following questions: How pervasive is religious diversity? Does the reality of this diversity require a response? Can a person who acknowledges religious diversity remain justified in claiming just one perspective to be correct? If so, is it morally justifiable to attempt to convert others to a different perspective? Can it justifiably be claimed that only one religion offers a path into the eternal presence of God? The answers to such questions are not simply academic. They increasingly have great impact on how we treat others, both personally and corporately. (shrink)