In lieu of an abstract, here is a brief excerpt of the content:When Should “Riskier” Subjects Be Excluded from Research Participation?*Dave Wendler** (bio)AbstractThe exclusion of potential subjects based on increased risks is a common practice in human subjects research. However, there are no guidelines to ensure that this practice is conducted in a systematic and fair way. This gap in the literature and regulations is addressed by a specific account of a “condition on inclusion risks” (CIR), a condition under (...) which potential subjects should be excluded from research on the basis of increased risks. This account provides a general framework for assessing standard exclusions as well as more controversial ones such as the exclusion of pregnant women and women of childbearing potential from certain types of research.The exclusion of potential subjects on the basis of increased risks is a common and, in most instances, noncontroversial practice in human subjects research. Investigators routinely exclude potential subjects with reduced kidney function, bleeding disorders, and allergies to the drugs under investigation. Surprisingly, this use of exclusion criteria takes place in the absence of any explicit guidelines. In the present paper, I attempt to fill this gap in the literature and regulations by offering a specific account of the conditions under which potential subjects should be excluded from research on the basis of increased risk. This account serves two purposes.First, subjects who are excluded on the basis of increased risk are prevented from making their own enrollment decisions. Therefore, it is important to ensure, in spite of the broad range of potential subjects and the varied reasons for excluding them, that potential subjects are excluded in [End Page 307] a systematic and fair way. Second, certain instances of subject exclusion, most notably the exclusion of pregnant women and women of childbearing potential, raise more difficult issues. By providing a general framework for assessing the exclusion of potential subjects based on increased risks, the present analysis covers these cases as well and, thus, offers a solution to one of the thornier ethical dilemmas facing investigators and IRBs today.Briefly, I argue that standard exclusion practices suggest that whenever two groups of potential research subjects offer the same opportunity for scientific and individual benefit, but different levels of risk, the group that would introduce greater risks should be excluded. With this framework in place, I consider potential subjects, such as men and women of child-parenting potential, whose research participation introduces increased risks to third parties. I argue that the present approach is justified, not because it reduces harms to specific individuals, but because it reduces aggregate harms. Therefore, it should be applied to all riskier potential subjects regardless of who faces the risks in question. After defending this approach, I consider several objections.First, I argue that the present approach is not paternalistic; the exclusions it calls for are not justified by what is thought to be in the best interests of the individuals excluded. Rather, the argument is that these exclusions minimize the aggregate harm of human subjects research. In addition, the present approach does not violate the obligation of researchers to respect subject autonomy because it does not reduce the number of potential subjects who are given the opportunity to enroll in a particular protocol. Finally, the exclusions are consistent with reasonable side constraints on attaining the goals of research.“Riskier” SubjectsWhen it comes to evaluating risks, most guidelines on human subjects research stipulate simply that the risks entailed must be reasonable given the potential for benefit. The Australian National Health and Medical Research Council’s guidelines, for instance, require only that “the investigator... must be satisfied that the possible advantage to be gained from the work justifies any discomfort or risk involved” (ANMRC 1992, Clause 3). To determine whether the risks of a protocol are justified, one sums the risks of the various procedures in the protocol, whatever those procedures may be, and compares the result to the procedures’ potential for benefit. This evaluation of risks assumes that the aggregate risks of a [End Page 308] given protocol are fixed and thus will not help to determine whether and when the risks of particular protocols should be reduced by excluding riskier subjects. The United States Department of Health... (shrink)

In this wide-ranging interview, Dave Elder-Vass discusses his main contributions to critical realist theory over two decades. In the first half, he explains his early work on emergence, agency, str...

Background The field of personal health monitoring (PHM) develops rapidly in different contexts, including the armed forces. Understanding the ethical dimension of this type of monitoring is key to a morally responsible development, implementation and usage of PHM within the armed forces. Research on the ethics of PHM has primarily been carried out in civilian settings, while the ethical dimension of PHM in the armed forces remains understudied. Yet, PHM of military personnel by design takes place in a different setting (...) than PHM of civilians, because of their tasks and the context in which they operate. This case study therefore focusses on obtaining insights into the experiences and related values of different stakeholders regarding an existing form of PHM, the Covid-19 Radar app, in the Netherlands Armed Forces. Methods We carried out an exploratory qualitative study, using semi-structured interviews with twelve stakeholders in the Netherlands Armed Forces. We focussed on participation in the use of PHM, reflections on the practical use and use of data, moral dilemmas and the need for ethics support, all in regard to PHM. The data was analysed using an inductive thematic approach. Results Three interlinking categories reflecting ethical dimensions of PHM emerged: (1) values, (2) moral dilemmas, and (3) external norms. The main values identified were: security (in relation to data), trust and hierarchy. Multiple related values were found. Some, but no broadly shared, moral dilemmas were identified and no strong need for ethics support was expressed. Conclusion This study shed light on key values, provide insights in the experienced and presumed moral dilemmas and bring to mind ethics support considerations when looking at PHM in the armed forces. Some values bring a certain vulnerability to military users when personal and organisational interests are not aligned. Furthermore, some identified values may hinder a careful consideration of PHM because they potentially conceal parts of ethical dimensions of PHM. Ethics support can assist in uncovering and addressing these concealed parts. The findings highlight a moral responsibility for the armed forces to devote attention to the ethical dimensions of PHM. (shrink)

Buddhism is all about training the mind, and boot camp is an ideal training method for this generation's short attention span. The chapters in this small book can be read in any order, and are simple and easy to understand. Each story, inspirational quote, and teaching offers mindfulness-enhancing techniques that anyone can relate to. You don't need to be a Buddhist to find the Buddha's teachings motivational. As the Dalai Lama says, "Don't try to use what you learn from Buddhism (...) to be a Buddhist; use it to be a better whatever-you-already-are." So whether it's Mother Teresa's acts of charity, Gandhi's perseverance, or your aunt Betty's calm demeanor, as long as you're motivated to be better today than you were yesterday, it doesn't matter who inspires you. Regardless of religion, geographical region, race, ethnicity, color, gender, sexual orientation, age, ability, flexibility, or vulnerability, if you do good you feel good, and if you do bad you feel bad. Buddhism isn't just about meditating. It's about rolling up your sleeves to relieve some of the suffering in the world. If you are ready to be a soldier of peace in the army of love, welcome to Buddhist Boot Camp! (shrink)

_The Invisible Dragon_ made a lot of noise for a little book When it was originally published in 1993 it was championed by artists for its forceful call for a reconsideration of beauty—and savaged by more theoretically oriented critics who dismissed the very concept of beauty as naive, igniting a debate that has shown no sign of flagging. With this revised and expanded edition, Hickey is back to fan the flames. More manifesto than polite discussion, more call to action than (...) criticism, _The Invisible Dragon_ aims squarely at the hyper-institutionalism that, in Hickey’s view, denies the real pleasures that draw us to art in the first place. Deploying the artworks of Warhol, Raphael, Caravaggio, and Mapplethorpe and the writings of Ruskin, Shakespeare, Deleuze, and Foucault, Hickey takes on museum culture, arid academicism, sclerotic politics, and more—all in the service of making readers rethink the nature of art. A new introduction provides a context for earlier essays—what Hickey calls his "intellectual temper tantrums." A new essay, "American Beauty," concludes the volume with a historical argument that is a rousing paean to the inherently democratic nature of attention to beauty. Written with a verve that is all too rare in serious criticism, this expanded and refurbished edition of _The Invisible Dragon_ will be sure to captivate a new generation of readers, provoking the passionate reactions that are the hallmark of great criticism. (shrink)

Rene Descartes is the 16th century philosopher who perpetually doubted everything--even his own physical existence!

What are the acceptable limits of scientific investigation and genetic engineering, the rights and wrongs of animal rights, euthanasia and civil disobedience? This book confronts these dilemmas, tracing arguments of moral thinkers, including Socrates, Plato, Aristotle, and brings us up to date with postmodern critics.

As free‐living organisms, alpha‐proteobacteria produce reactive oxygen species (ROS) that diffuse into the surroundings; once constrained inside the archaeal ancestor of eukaryotes, however, ROS production presented evolutionary pressures – especially because the alpha‐proteobacterial symbiont made more ROS, from a variety of substrates. I previously proposed that ratios of electrons coming from FADH2 and NADH (F/N ratios) correlate with ROS production levels during respiration, glucose breakdown having a much lower F/N ratio than longer fatty acid (FA) breakdown. Evidently, higher endogenous ROS (...) formation did not hinder eukaryotic evolution, so how were its disadvantages mitigated? I propose that the resulting selection pressures favoured the evolution of a variety of eukaryotic ‘innovations’: peroxisomes for FA breakdown, carnitine shuttles, the linkage of beta‐oxidation to antioxidant properties, uncoupling proteins (UCPs) and using mitochondrial uncoupling during beta‐oxidation to reduce ROS. Recently observed relationships between peroxisomes and mitochondria further support the model. (shrink)

Neurotheology is a fast-growing field of research. Combining philosophy of mind, neuroscience, and religious studies, it takes a new approach to old questions on religion. What is religion and why do we have it? Neurotheologists focus on the search for the neural correlate of religious experiences. If we can trace religious experiences to specific parts of the brain, chances are we can reduce religion as such to that grey soggy matter as well. This article predicts neurotheology will not be able (...) to locate the neural correlate of religious experiences. As we cannot decide phenomenally what makes an experience religious, neurologically we cannot find its correlate either. That is, if there are fixed neural correlates to begin with, because their existence is still a matter of debate. In addition, religious experiences seem to be a kind of experience, like emotional or relational experiences, making them indistinguishable from similar nonreligious experiences. Even if one manages to trace the neural correlate of religious experiences, neurotheology will still not be able to account for the rise of religion without resorting to theories from other disciplines. In the end, we do not know enough about consciousness and the way it relates to the brain to make conclusive claims about the search for religious states of consciousness. It seems, however, that even though neurotheology could provide fascinating insights in the workings of the religious brain, on its own, it will prove unable to explain religion fully. (shrink)

Recently, constructive neutral evolution has been touted as an important concept for the understanding of the emergence of cellular complexity. It has been invoked to help explain the development and retention of, amongst others, RNA splicing, RNA editing and ribosomal and mitochondrial respiratory chain complexity. The theory originated as a welcome explanation of isolated small scale cellular idiosyncrasies and as a reaction to ‘overselectionism’. Here I contend, that in its extended form, it has major conceptual problems, can not explain observed (...) patterns of complex processes, is too easily dismissive of alternative selectionist models, underestimates the creative force of complexity as such, and – if seen as a major evolutionary mechanism for all organisms – could stifle further thought regarding the evolution of highly complex biological processes. (shrink)

This introduction to a special issue of Topoi introduces and summarises the relationship between three main varieties of 'enactivist' theorising about the mind: 'autopoietic', 'sensorimotor', and 'radical' enactivism. It includes a brief discussion of the philosophical and cognitive scientific precursors to enactivist theories, and the relationship of enactivism to other trends in embodied cognitive science and philosophy of mind.

Ethical challenges in genomic epidemiology are the direct result of novel tools used to confront scientific challenges in the field. An orders-of-magnitude increase in scale of genetic data collection has created the need for establishing diffuse international partnerships, sometimes across developed- and developing-world countries, with ramifications for assigning research ownership, distributing intellectual property rights, and encouraging capacity-building. Meanwhile, the fact that genomic epidemiological research is so far upstream in the pipeline of therapy development has implications for the privacy rights of (...) research participants and for a rigorous definition of valid informed consent, particularly in resource-poor settings. From these scientific underpinnings, we distill out two main categories of ethical issues: (1) How should researchers ensure that the subjects of research are appropriately protected? and (2) What is the structure of an equitable and fair system for distributing the financial and scientific rewards of research? We attempt to delineate the contours of specific problems in each category and propose steps toward solutions with reference to a particular project, known as gMap.net, that focuses on genomic epidemiological studies of malaria. (shrink)

We present a specific elaboration and partial defense of the claims that cognition is enactive, embodied, embedded, affective and (potentially) extended. According to the view we will defend, the enactivist claim that perception and cognition essentially depend upon the cognizer’s interactions with their environment is fundamental. If a particular instance of this kind of dependence obtains, we will argue, then it follows that cognition is essentially embodied and embedded, that the underpinnings of cognition are inextricable from those of affect, that (...) the phenomenon of cognition itself is essentially bound up with affect, and that the possibility of cognitive extension depends upon the instantiation of a specific mode of skillful interrelation between cognizer and environment. Thus, if cognition is enactive then it is also embodied, embedded, affective and potentially extended. (shrink)

Social and linguistic perceptions are linked. On one hand, talker identity affects speech perception. On the other hand, speech itself provides information about a talker's identity. Here, we propose that the same probabilistic knowledge might underlie both socially conditioned linguistic inferences and linguistically conditioned social inferences. Our computational–level approach—the ideal adapter—starts from the idea that listeners use probabilistic knowledge of covariation between social, linguistic, and acoustic cues in order to infer the most likely explanation of the speech signals they hear. (...) As a first step toward understanding social inferences in this framework, we use a simple ideal observer model to show that it would be possible to infer aspects of a talker's identity using cue distributions based on actual speech production data. This suggests the possibility of a single formal framework for social and linguistic inferences and the interactions between them. (shrink)

Author David Skrbina argues that all of technology is metaphysically driven by a panpsychic force called the Pantechnicon.

Graphical Abstract Reading Venki Ramakrishnan's “Gene Machine”, describing the race to decipher the structure of the ribosome, inspired thoughts on the power of the internet: mostly for good in science, but often detrimental to society. Why is this so? The non-ideological nature of science holds part of the answer.

Shows how ethical subjectivity is not based on individual morals but contemporary cultureTaking his lead from the philosophy of Emmanuel Levinas, and engaging with a number of ethical thinkers, Dave Boothroyd addresses a number of key contemporary ethical subjects. In doing so, he reveals how responsibility is grounded in the everyday encounters and situations we are all familiar with.

An eye-opening tour of the political tricks that subvert scientific progress. The Butter-Up and Undercut. The Certain Uncertainty. The Straight-Up Fabrication. Dave Levitan dismantles all of these deceptive arguments, and many more, in this probing and hilarious examination of the ways our elected officials attack scientific findings that conflict with their political agendas. The next time you hear a politician say, "Well, I’m not a scientist, but…," you’ll be ready.

The first complete history of Minneapolis and St Paul published in two decades. The book spans their ramshackle beginnings as cross-river rivals to their thriving metropolitan partnership today.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Nature of Space by Milton SantosDave McLaughlinThe Nature of Spaceby milton santos (trans. by brenda baletti) Durham, N.C.: Duke University Press, 2021When asked to review Milton Santos’s The Nature of Space, I was interested mostly in the book’s core theme. As a literary geographer, my own research focuses heavily on space as an analytical concept and a lived experience; I was keen to read and understand a (...) fresh perspective on this topic. Little did I know that opening this book would connect me to a world of geography scholarship for the most part ignored, actively or otherwise, in the Anglophone academy. For my sins, I was not alone in this ignorance. In 2017, for example, one scholar felt confident in writing that:The English-speaking geographical community knows very little about the theoretical work in geography being produced in the so-called [End Page 147] “global South.” They are unaware, for example, of the work of Brazilian geographer Milton Santos.1It is not my place here to write about the reasons why this is such a mistake. Others, better qualified than me, have already done so.2 My aim here is to do three things. First, to put Santos’s arrival into English-language geography in context; second, to consider briefly his key contribution to defining the nature of space; and finally, to touch on what Santos’s book offers us more broadly.Published in 2021, Brenda Baletti’s translation of Santos’s great work arrived on the crest of a wave of discussions, debates, and scholarly interventions around decoloniality in Western geography. This movement emphasizes uncovering “still colonising frames of knowledge”3—frames “through which the world is apprehended and explained and modelled for the future”—and “craft[ing] ways of thinking harder about and against them.”4 Others have argued that the long wait for an English translation of Santos’s The Nature of Space is evidence of just such modes of thought continuing, unreflectively, among Anglophone academia. In 2019, an English-language translation of Santos’s For a New Geography was published by the University of Minnesota Press, followed by The Nature of Space in 2021. Hopefully, publications indicate that some publishers, at least, are following Stephen Legg’s call to think hard against certain predominant Western frames.The Nature of Space, despite its mere 280 pages, is an opus of sorts. Santos’s style eschews narrow conceptualization in favor of building a solid theory of space on a remarkably broad foundation of thinkers, including Braudel, Merleau-Ponty, Habermas, Latour, and many, many others. This broad foundation is a result not only of his long career and his own widely travelled life; it is necessary due to the slippery and almost-undefinable nature of space itself. In a wonderful section of For a New Geography, Santos lays out the problem facing geographers in defining this concept around which our discipline revolves:I understand why geographers have spent more time defining geography than space as the latter is extremely hard to do. The same could be said of space as Saint Augustine said of time: “if I ask myself if I know [End Page 148] what it is, I respond that I do; but, if I ask myself to define it, I respond that I do not know how.”5Part of this complication, recognized by Santos, is that “space” is a word with many meanings outside academia.6 Yet, geographers also face no simple task in defining this core concept for our own needs. Doreen Massey’s definition from For Space is one of my favorites, not only because it well illustrates the complexity of the term “space,” but also due to the range of reactions it produces in my first-year undergraduate students when I introduce it: Space is the sphere of the possibility of the existence of multiplicity in the sense of contemporaneous plurality.7 This is a very crunchy sentence! But it gets to the heart of a conceptually complex truth: that space is the dimension in which things happen, a dimension in which we must live at all times, as well as... (shrink)

Soren Kierkegaard is widely held to be the founder of existentialism. His faith is ironic, playful and passionate, and he wrote like a novelist. This book brilliantly explains his life and thought.

Mark Edmundson explores and defends the value of ideals in contemporary culture, focusing on courage, contemplation and compassion. In his argument, he explicates the ideas of authors and thinkers such Homer, Plato, and the Christian and Eastern religious traditions. Shakespeare and Frued are seen as detractors of the Soul.