In lieu of an abstract, here is a brief excerpt of the content:When Should “Riskier” Subjects Be Excluded from Research Participation?*Dave Wendler** (bio)AbstractThe exclusion of potential subjects based on increased risks is a common practice in human subjects research. However, there are no guidelines to ensure that this practice is conducted in a systematic and fair way. This gap in the literature and regulations is addressed by a specific account of a “condition on inclusion risks” (CIR), a condition under (...) which potential subjects should be excluded from research on the basis of increased risks. This account provides a general framework for assessing standard exclusions as well as more controversial ones such as the exclusion of pregnant women and women of childbearing potential from certain types of research.The exclusion of potential subjects on the basis of increased risks is a common and, in most instances, noncontroversial practice in human subjects research. Investigators routinely exclude potential subjects with reduced kidney function, bleeding disorders, and allergies to the drugs under investigation. Surprisingly, this use of exclusion criteria takes place in the absence of any explicit guidelines. In the present paper, I attempt to fill this gap in the literature and regulations by offering a specific account of the conditions under which potential subjects should be excluded from research on the basis of increased risk. This account serves two purposes.First, subjects who are excluded on the basis of increased risk are prevented from making their own enrollment decisions. Therefore, it is important to ensure, in spite of the broad range of potential subjects and the varied reasons for excluding them, that potential subjects are excluded in [End Page 307] a systematic and fair way. Second, certain instances of subject exclusion, most notably the exclusion of pregnant women and women of childbearing potential, raise more difficult issues. By providing a general framework for assessing the exclusion of potential subjects based on increased risks, the present analysis covers these cases as well and, thus, offers a solution to one of the thornier ethical dilemmas facing investigators and IRBs today.Briefly, I argue that standard exclusion practices suggest that whenever two groups of potential research subjects offer the same opportunity for scientific and individual benefit, but different levels of risk, the group that would introduce greater risks should be excluded. With this framework in place, I consider potential subjects, such as men and women of child-parenting potential, whose research participation introduces increased risks to third parties. I argue that the present approach is justified, not because it reduces harms to specific individuals, but because it reduces aggregate harms. Therefore, it should be applied to all riskier potential subjects regardless of who faces the risks in question. After defending this approach, I consider several objections.First, I argue that the present approach is not paternalistic; the exclusions it calls for are not justified by what is thought to be in the best interests of the individuals excluded. Rather, the argument is that these exclusions minimize the aggregate harm of human subjects research. In addition, the present approach does not violate the obligation of researchers to respect subject autonomy because it does not reduce the number of potential subjects who are given the opportunity to enroll in a particular protocol. Finally, the exclusions are consistent with reasonable side constraints on attaining the goals of research.“Riskier” SubjectsWhen it comes to evaluating risks, most guidelines on human subjects research stipulate simply that the risks entailed must be reasonable given the potential for benefit. The Australian National Health and Medical Research Council’s guidelines, for instance, require only that “the investigator... must be satisfied that the possible advantage to be gained from the work justifies any discomfort or risk involved” (ANMRC 1992, Clause 3). To determine whether the risks of a protocol are justified, one sums the risks of the various procedures in the protocol, whatever those procedures may be, and compares the result to the procedures’ potential for benefit. This evaluation of risks assumes that the aggregate risks of a [End Page 308] given protocol are fixed and thus will not help to determine whether and when the risks of particular protocols should be reduced by excluding riskier subjects. The United States Department of Health... (shrink)

In this wide-ranging interview, Dave Elder-Vass discusses his main contributions to critical realist theory over two decades. In the first half, he explains his early work on emergence, agency, str...

Buddhism is all about training the mind, and boot camp is an ideal training method for this generation's short attention span. The chapters in this small book can be read in any order, and are simple and easy to understand. Each story, inspirational quote, and teaching offers mindfulness-enhancing techniques that anyone can relate to. You don't need to be a Buddhist to find the Buddha's teachings motivational. As the Dalai Lama says, "Don't try to use what you learn from Buddhism (...) to be a Buddhist; use it to be a better whatever-you-already-are." So whether it's Mother Teresa's acts of charity, Gandhi's perseverance, or your aunt Betty's calm demeanor, as long as you're motivated to be better today than you were yesterday, it doesn't matter who inspires you. Regardless of religion, geographical region, race, ethnicity, color, gender, sexual orientation, age, ability, flexibility, or vulnerability, if you do good you feel good, and if you do bad you feel bad. Buddhism isn't just about meditating. It's about rolling up your sleeves to relieve some of the suffering in the world. If you are ready to be a soldier of peace in the army of love, welcome to Buddhist Boot Camp! (shrink)

_The Invisible Dragon_ made a lot of noise for a little book When it was originally published in 1993 it was championed by artists for its forceful call for a reconsideration of beauty—and savaged by more theoretically oriented critics who dismissed the very concept of beauty as naive, igniting a debate that has shown no sign of flagging. With this revised and expanded edition, Hickey is back to fan the flames. More manifesto than polite discussion, more call to action than (...) criticism, _The Invisible Dragon_ aims squarely at the hyper-institutionalism that, in Hickey’s view, denies the real pleasures that draw us to art in the first place. Deploying the artworks of Warhol, Raphael, Caravaggio, and Mapplethorpe and the writings of Ruskin, Shakespeare, Deleuze, and Foucault, Hickey takes on museum culture, arid academicism, sclerotic politics, and more—all in the service of making readers rethink the nature of art. A new introduction provides a context for earlier essays—what Hickey calls his "intellectual temper tantrums." A new essay, "American Beauty," concludes the volume with a historical argument that is a rousing paean to the inherently democratic nature of attention to beauty. Written with a verve that is all too rare in serious criticism, this expanded and refurbished edition of _The Invisible Dragon_ will be sure to captivate a new generation of readers, provoking the passionate reactions that are the hallmark of great criticism. (shrink)

Rene Descartes is the 16th century philosopher who perpetually doubted everything--even his own physical existence!

What are the acceptable limits of scientific investigation and genetic engineering, the rights and wrongs of animal rights, euthanasia and civil disobedience? This book confronts these dilemmas, tracing arguments of moral thinkers, including Socrates, Plato, Aristotle, and brings us up to date with postmodern critics.

As free‐living organisms, alpha‐proteobacteria produce reactive oxygen species (ROS) that diffuse into the surroundings; once constrained inside the archaeal ancestor of eukaryotes, however, ROS production presented evolutionary pressures – especially because the alpha‐proteobacterial symbiont made more ROS, from a variety of substrates. I previously proposed that ratios of electrons coming from FADH2 and NADH (F/N ratios) correlate with ROS production levels during respiration, glucose breakdown having a much lower F/N ratio than longer fatty acid (FA) breakdown. Evidently, higher endogenous ROS (...) formation did not hinder eukaryotic evolution, so how were its disadvantages mitigated? I propose that the resulting selection pressures favoured the evolution of a variety of eukaryotic ‘innovations’: peroxisomes for FA breakdown, carnitine shuttles, the linkage of beta‐oxidation to antioxidant properties, uncoupling proteins (UCPs) and using mitochondrial uncoupling during beta‐oxidation to reduce ROS. Recently observed relationships between peroxisomes and mitochondria further support the model. (shrink)

Neurotheology is a fast-growing field of research. Combining philosophy of mind, neuroscience, and religious studies, it takes a new approach to old questions on religion. What is religion and why do we have it? Neurotheologists focus on the search for the neural correlate of religious experiences. If we can trace religious experiences to specific parts of the brain, chances are we can reduce religion as such to that grey soggy matter as well. This article predicts neurotheology will not be able (...) to locate the neural correlate of religious experiences. As we cannot decide phenomenally what makes an experience religious, neurologically we cannot find its correlate either. That is, if there are fixed neural correlates to begin with, because their existence is still a matter of debate. In addition, religious experiences seem to be a kind of experience, like emotional or relational experiences, making them indistinguishable from similar nonreligious experiences. Even if one manages to trace the neural correlate of religious experiences, neurotheology will still not be able to account for the rise of religion without resorting to theories from other disciplines. In the end, we do not know enough about consciousness and the way it relates to the brain to make conclusive claims about the search for religious states of consciousness. It seems, however, that even though neurotheology could provide fascinating insights in the workings of the religious brain, on its own, it will prove unable to explain religion fully. (shrink)

Recently, constructive neutral evolution has been touted as an important concept for the understanding of the emergence of cellular complexity. It has been invoked to help explain the development and retention of, amongst others, RNA splicing, RNA editing and ribosomal and mitochondrial respiratory chain complexity. The theory originated as a welcome explanation of isolated small scale cellular idiosyncrasies and as a reaction to ‘overselectionism’. Here I contend, that in its extended form, it has major conceptual problems, can not explain observed (...) patterns of complex processes, is too easily dismissive of alternative selectionist models, underestimates the creative force of complexity as such, and – if seen as a major evolutionary mechanism for all organisms – could stifle further thought regarding the evolution of highly complex biological processes. (shrink)

This introduction to a special issue of Topoi introduces and summarises the relationship between three main varieties of 'enactivist' theorising about the mind: 'autopoietic', 'sensorimotor', and 'radical' enactivism. It includes a brief discussion of the philosophical and cognitive scientific precursors to enactivist theories, and the relationship of enactivism to other trends in embodied cognitive science and philosophy of mind.

Ethical challenges in genomic epidemiology are the direct result of novel tools used to confront scientific challenges in the field. An orders-of-magnitude increase in scale of genetic data collection has created the need for establishing diffuse international partnerships, sometimes across developed- and developing-world countries, with ramifications for assigning research ownership, distributing intellectual property rights, and encouraging capacity-building. Meanwhile, the fact that genomic epidemiological research is so far upstream in the pipeline of therapy development has implications for the privacy rights of (...) research participants and for a rigorous definition of valid informed consent, particularly in resource-poor settings. From these scientific underpinnings, we distill out two main categories of ethical issues: (1) How should researchers ensure that the subjects of research are appropriately protected? and (2) What is the structure of an equitable and fair system for distributing the financial and scientific rewards of research? We attempt to delineate the contours of specific problems in each category and propose steps toward solutions with reference to a particular project, known as gMap.net, that focuses on genomic epidemiological studies of malaria. (shrink)

We present a specific elaboration and partial defense of the claims that cognition is enactive, embodied, embedded, affective and (potentially) extended. According to the view we will defend, the enactivist claim that perception and cognition essentially depend upon the cognizer’s interactions with their environment is fundamental. If a particular instance of this kind of dependence obtains, we will argue, then it follows that cognition is essentially embodied and embedded, that the underpinnings of cognition are inextricable from those of affect, that (...) the phenomenon of cognition itself is essentially bound up with affect, and that the possibility of cognitive extension depends upon the instantiation of a specific mode of skillful interrelation between cognizer and environment. Thus, if cognition is enactive then it is also embodied, embedded, affective and potentially extended. (shrink)

Social and linguistic perceptions are linked. On one hand, talker identity affects speech perception. On the other hand, speech itself provides information about a talker's identity. Here, we propose that the same probabilistic knowledge might underlie both socially conditioned linguistic inferences and linguistically conditioned social inferences. Our computational–level approach—the ideal adapter—starts from the idea that listeners use probabilistic knowledge of covariation between social, linguistic, and acoustic cues in order to infer the most likely explanation of the speech signals they hear. (...) As a first step toward understanding social inferences in this framework, we use a simple ideal observer model to show that it would be possible to infer aspects of a talker's identity using cue distributions based on actual speech production data. This suggests the possibility of a single formal framework for social and linguistic inferences and the interactions between them. (shrink)

Author David Skrbina argues that all of technology is metaphysically driven by a panpsychic force called the Pantechnicon.

Graphical Abstract Reading Venki Ramakrishnan's “Gene Machine”, describing the race to decipher the structure of the ribosome, inspired thoughts on the power of the internet: mostly for good in science, but often detrimental to society. Why is this so? The non-ideological nature of science holds part of the answer.

Shows how ethical subjectivity is not based on individual morals but contemporary cultureTaking his lead from the philosophy of Emmanuel Levinas, and engaging with a number of ethical thinkers, Dave Boothroyd addresses a number of key contemporary ethical subjects. In doing so, he reveals how responsibility is grounded in the everyday encounters and situations we are all familiar with.

An eye-opening tour of the political tricks that subvert scientific progress. The Butter-Up and Undercut. The Certain Uncertainty. The Straight-Up Fabrication. Dave Levitan dismantles all of these deceptive arguments, and many more, in this probing and hilarious examination of the ways our elected officials attack scientific findings that conflict with their political agendas. The next time you hear a politician say, "Well, I’m not a scientist, but…," you’ll be ready.

Big business moguls seem determined to dismantle public schools in the name of a market driven system of educating children via vouchers and charter schools. No Child Left Behind contributes to this business-model and penalizes children and teachers with unrealistic expectations and expensive unnecessary testing. Research indicates that NCLB, charter schools, and vouchers do not improve students’ learning or help educators teach better. The facts presented herein are evidence of public school successes and provide reasons to honor public school educators (...) and support public schools across America. (shrink)

The first complete history of Minneapolis and St Paul published in two decades. The book spans their ramshackle beginnings as cross-river rivals to their thriving metropolitan partnership today.

Soren Kierkegaard is widely held to be the founder of existentialism. His faith is ironic, playful and passionate, and he wrote like a novelist. This book brilliantly explains his life and thought.

Mark Edmundson explores and defends the value of ideals in contemporary culture, focusing on courage, contemplation and compassion. In his argument, he explicates the ideas of authors and thinkers such Homer, Plato, and the Christian and Eastern religious traditions. Shakespeare and Frued are seen as detractors of the Soul.

Bien que le paysage institutionnel de la Belgique reflète une gestion politique assez complexe des identités linguistiques, la logique et la dynamique sous-jacente est celle d'une institutionnalisation des identités linguistiques, basée sur deux principes récurrents: la territorialité et la bipolarité. En introduction, est présentée une esquisse de la construction des identités linguistiques en Belgique au cours du XIX siècle. Ensuite sont exposés quatre principes fondamentaux qui furent instaurés dans la législation belge durant le XX siècle. Ceux-ci visaient à régler le (...) contentieux linguistique en Belgique et ont contribué à façonner le visage actuel du modèle belge: principe de territorialité et plus précisément unilinguisme régional; fixation d'une frontière linguistique; mécanismes de protection parlementaire pour la minorité linguistique au niveau national et bruxellois; décentralisation culturelle et socio-économique.Although the institutional landscape of Belgium reflects a political management rather complex linguistic, logic and dynamics underlying the institutionalization of linguistic identities, based on two principles recurring: territoriality and bipolarity. In the introduction, is presented a sketch of the construction of linguistic identities in Belgium during the nineteenth century. Then exposed four fundamental principles that were established in the Belgian legislation during the twentieth century. These were designed to address the contentious language in Belgium and helped shape the current face of the Belgian model: territoriality principle and more specifically unilingualism regional setting of a linguistic border, protection mechanisms for parliamentary minority language at the national level and Brussels, decentralization cultural and socio-economic development. (shrink)