The present study is an attempt to relate the multicomponent response of the cytoskeleton (CSK), evaluated in twisted living adherent cells, to the heterogeneity of the cytoskeletal structure - evaluated both experimentally by means of 3D reconstructions, and theoretically considering the predictions given by two tensegrity models composed of (four and six) compressive elements and (respectively 12 and 24) tensile elements. Using magnetic twisting cytometry in which beads are attached to integrin receptors linked to the actin CSK of living adherent (...) epithelial cells, we specifically measured the elastic CSK response at quasi equilibrium state and partitioned this response in terms of cortical and cytosolic contributions with a two-component model (i.e., a series of two Voigt bodies). These two CSK components were found to be prestressed and exhibited a stress-hardening response which both characterize tensegrity behaviour with however significant differences: compared to the cytosolic component, the cortical cytoskeleton appears to be a faster responding component, being a less prestressed and easily deformable structure. The discrepancies in elastic behaviour between the cortical and cytosolic CSK components may be understood on the basis of prestress tensegrity model predictions, given that the length and number of constitutive actin elements are taken into account. (shrink)

Mary is confined to a black-and-white room, is educated through black-and-white books and through lectures relayed on black-and white television. In this way she learns everything there is to know about the physical nature of the world. She knows all the physical facts about us and our environment, in a wide sense of 'physical' which includes everything in completed physics, chemistry, and neurophysiology, and all there is to know about the causal and relational facts consequent upon all this, including of (...) course functional roles. If physicalism is true, she knows all there is to know. For to suppose otherwise is to suppose that there is more to know than every physical fact, and that is just what physicalism denies. … It seems, however, that Mary does not know all there is to know. For when she is let out of the black-and- white room or given a color television, she will learn what it is like to see something red, say. This is rightly described as learning—she will not say “ho, hum.” Hence, physicalism is false. (Jackson 1986, p. 291, Chapter 2, this volume). (shrink)

ABSTRACT This article advances a novel way of understanding humor and stand-up comedy. I propose that the relationship between the comedian and her audience is understood by way of trust, where the comedian requires the trust of her audience for her humor to succeed. The comedian may hold the trust of the audience in two domains. She may be trusted as to the form of the humor, such as whether she is joking. She may also be trusted as to the (...) content of the joke. This approach has two distinct virtues. The first is that it makes sense of partial successes. These are cases where the humor neither completely succeeds nor fails because the audience does not fully trust the comedian. The second is that it explains intuitions about ethically dubious humor and why certain classes of humor, especially those dealing in racialized and gendered identities, are more readily accepted from humorists of those identities. (shrink)

Metaphysics has undergone two major innovations in recent decades. First, naturalistic metaphysicians have argued that our best science provides an important source of evidence for metaphysical theories. Second, social metaphysicians have begun to explore the nature of social entities such as groups, institutions, and social categories. Surprisingly, these projects have largely kept their distance from one another. Katherine Hawley has recently argued that, unlike the natural sciences, the social sciences are not sufficiently successful to provide evidence about the metaphysical nature (...) of social entities. By contrast, I defend an optimistic view of naturalistic social metaphysics. Drawing on a case study of research into contextual effects in social epidemiology, I show that social science can provide a valuable evidence for social metaphysicians. (shrink)

The process of constructing a social reality where “difference” becomes a social asset rather than a monster that threatens peace and progress must commence with a phenomenological understanding of social interactions within and among human societies. In my opinion, Hegel, more than any other thinker, has constructed a phenomenological framework that adequately captures and represents the nature of group interactions within human societies. This paper explores the Hegelian phenomenon of social identity, and, especially, characterizes the interactions between and among various (...) social identities. It is a modest effort to contribute theoretically to the available discourse on the management of “difference” in multi-ethnic societies. (shrink)

In this dissertation I advance a Jaspersian account of the formation and possession of irrational attitudes. This account stands in opposition to two competing views – externalism and internalism with respect to rational and irrational attitudes. According to externalism, a subject’s attitudes are irrational when they fail to satisfy standards or criteria independent of the subject, such as laws of logic, methods for evidence acquisition, and rules of decision theory. According to internalism, a subject’s attitudes are irrational when they are (...) not supported by reasons selected by the subject. In this dissertation, I take Donald Davidson’s theory of rational and irrational attitudes to be a case of externalism and John Searle’s theory of rational and irrational attitudes to be a case of internalism. While articulating and identifying the merits of externalism and internalism with respect to rational or irrational attitudes, I argue that each account ends up in difficulties: Davidson’s externalism cannot account for the experience of freedom, an individual’s subjectivity, and is unable to avoid an infinite regress of rules; Searle’s internalism struggles to avoid solipsism and an infinite regress of reasons. Karl Jaspers’ account of rational and irrational attitude formation, I argue, avoids the pitfalls of Davidson’s and Searle’s views while preserving the merits of each. On Jaspers’ account, a subject possesses rational attitudes insofar as that subject holds those attitudes to be always open to revision while, at the same time, using those attitudes to bring unity to all manner of phenomena and other attitudes. Irrationality, by contrast, occurs, on the Jaspersian view, when a subject holds onto attitudes with complete and absolute resolution and interprets all else according to these attitudes. Having defined a Jaspersian account of rational and irrational attitudes, I show how it accounts for the irrationality of delusional beliefs and the irrationality of certain worldviews. On Jaspers’ view, I argue, delusions and worldviews are irrational insofar as they are held with absolute conviction, are unamenable to modification, and are used to understand all available evidence, views, and opinions. (shrink)

Equality, similarity and congruence are essential elements of Kant’s theory of geometrical cognition; nevertheless, Kant’s account of them is not well understood. This paper provides historical context for treatments of these geometrical relations, presents Kant’s views on their mathematical definitions, and explains Kant’s theory of their cognition. It also places Kant’s theory within the larger context of his understanding of the quality-quantity distinction. Most importantly, it argues that the relation of equality, in conjunction with the categories of quantity, plays a (...) pivotal and wide-ranging role in Kant’s account of mathematical cognition. (shrink)

In _The Smile of Tragedy_, Daniel Ahern examines Nietzsche’s attitude toward what he called “the tragic age of the Greeks,” showing it to be the foundation not only for his attack upon the birth of philosophy during the Socratic era but also for his overall critique of Western culture. Through an interpretation of “Dionysian pessimism,” Ahern clarifies the ways in which Nietzsche sees ethics and aesthetics as inseparable and how their theoretical separation is at the root of Western nihilism. (...) Ahern explains why Nietzsche, in creating this precursor to a new aesthetics, rejects Aristotle’s medicinal interpretation of tragic art and concentrates on Apollinian cruelty as a form of intoxication without which there can be no art. Ahern shows that Nietzsche saw the human body as the vessel through which virtue and art are possible, as the path to an interpretation of “selflessness,” as the means to determining an order of rank among human beings, and as the site where ethics and aesthetics coincide. (shrink)

The general knowledge of Brentano's ethical doctrines comes from the little book of his, Vom Ursprung sittlicher Erkenntnis, first published in 1889. Only the recent publications and the insight into his not yet published correspondence throw more light on the history of his axiology.

Analytic epistemology is traditionally interested in rational reconstructions of cognitive pro- cesses. The purpose of these rational reconstructions is to make plain how a certain cognitive process might eventually result in knowledge or justi?ed beliefs, etc., if we pre-theoretically think that we have such knowledge or such justi?ed beliefs. Typically a rational reconstruction assumes some unproblematic basis of knowledge and some justi?cation-preserving inference pattern and then goes on to show how these two su ce to generate the explicandum.

I first examine Origen’s notion of nature as personal, and secondly a modern presentation of the same theme by Erazim Kohak. I then consider possible scientific support given to both these authors’ accounts by Lovejoy. I conclude that there are many strengths in viewing nature as a whole as both divine and personal.

I try to clarify the ways in which one would seek to hold that language and/or thought are public. For each of these theses, I distinguish four forms in which they can be framed, and two ways of establishing them. The first will try to make the publicity of thought follow from that of language; the second will try to make the publicity of language follow from that of thought. I show that none of these strategies can do without the (...) thesis that language and thought are interdependent, and that even while admitting this thesis, the second strategy presents more difficulties than the first. (shrink)

La importancia de la esperanza en la vida de las personas es reconocida portodos; sin embargo, el tema ha sido trabajado casi exclusivamente porteólogos. El artículo intenta encontrar, mediante el análisis de los aportes deKant, Maree! y Bloch, un vocabulario que nos permita comprender laesperanza en términos filosóficos; es un ejercicio reflexivo de spes quaerensintellectum y, a la vez, de intellectus quaerens spem.

Narratives of human-induced environmental effects such as climate change and biodiversity decline have long been dominated by narratives of loss in which humankind is concep­tualized as a destructive force. But in addition to narratives of loss, there is a narrative of gain and resilience in nonfiction books intended for a general audience. Books employing this narrative emphasize that nature is dynamic and that some species are adapting to and flourishing thanks to human-induced changes. This review essay discusses two new books (...) in this vein: Chris D. Thomas’s Inheritors of the Earth and Menno Schilthuizen’s Darwin Comes to Town. I argue that these two books, besides being interesting in their own right, are important contributions to the popular literature on climate change and the Anthropocene because they denaturalize dominant apocalyptic narratives of nature. However, they underestimate the severity of human effect on the biosphere and advocate a form of anthropocentrism that may be misguided if our goal is to maintain a functioning biosphere for the future. (shrink)

This is a digest of how various researchers in biology and astrobiology have explored questions of what defines living organisms—definitions based on functions or structures observed in organisms, or on systems terms, or on mathematical conceptions like closure, chirality, quantum mechanics and thermodynamics, or on biosemiotics, or on Darwinian evolution—to clarify the field and make it easier for endeavors in artificial intelligence to make progress. Current ideas are described to promote work between astrobiologists and computer scientists, each concerned with living (...) organisms. A four-parameter framework is presented as a scaffold that is later developed into what machines lack to be considered alive: systems, evolution, energy and consciousness, and includes Jagers operators and the idea of dual closure. A novel definition of consciousness is developed which describes mental objects both with and without communicable properties, and this helps to clarify how consciousness in machines may be studied as an emergent process related to choice functions in systems. A perspective on how quantization, acting on nucleic acids, sets up natural limits to system behavior is offered as a partial address to the problem of biogenesis. (shrink)