Recent evidence shows that dynamic instability is the dominant mechanism for the assembly of pure tubulin in vitro and for the great majority of microtubules in the mitotic spindle and the interphase cytoplasmic microtubule complex. The basic concepts of this model provide a framework for future characterization of the molecular basis of spatial and temporal regulation of microtubule dynamics in the cell and the function of microtubule dynamics in motile processes such as chromosome movement.

This book is an outgrowth of a series of articles originally published in The Progress Magazine under a pseudonym, in which I sought to account for the prevailing mental unrest regarding subjects of religious and philosophical import. These articles attracted much attention from careful students of the times, and there have been many requests for the republication thereof in book form under my own name. Accordingly, the publishers of the articles requested me to revise the several papers, and to add (...) thereto such further matter as I might think proper. I have gone over the original articles, taking away a little here and adding much there. Several entirely new subjects have been considered and inserted in their proper places in the text. At least one third of the present book is entirely new, having been added to the revised form of the original articles. I have purposely quoted freely from good authorities, that the reader may have the benefit of the thought of a number of competent persons upon the various phases of the subject, in addition to what I have personally thought and written. I have sought merely to tell my story in a plain, simple manner, without any attempt at fine writing, literary excellence, or display of technical philosophical knowledge. My desire has been to place in the hands of the everyday busy man and woman a book from the pages of which they may gain a general knowledge of the causes of the modern mental unrest-an idea of what is going into this great melting pot of thought; what is happening there; and what is likely to be poured forth from it. To many, the numerous new "isms," "ologies" and cults, are entirely new- something sprung full grown from the brains of their founders. The absence of an elementary acquaintance with the history of philosophy, on the part of the average man and woman, has given to many new prophets and founders of cults an unmerited and unwarranted importance and authority. I trust that this book will enable some of those who have been perplexed and worried over these new (?) "isms," and teachings, to learn the true sources of those startling conglomerations of metaphysics, philosophy and theology, and thus once more to regain their mental bearings. It is also my hope that some who have a tendency toward philosophical study may be inspired by this book to go to the proper sources of such knowledge-to the masters of this branch of thought-instead of sitting at the feet of the, too often, freakish, irresponsible, and bizarre founders and teachers of the pseudo schools and cults, who have been revamping the old teachings, dressing them in fantastic garb, and offering them (usually at a high rate of compensation) to those who have felt the hunger for wisdom and the thirst for information, but who lacked the knowledge of the places where these things could be had at first hand, pure and free from the adulterations of these self constituted middle men in the great market of Philosophy. (shrink)

The primitive conception is that the future already exists like a terra incognita which one can dimly make out with or without the help of the gods. This idea is at the basis of fatalism and of belief in prophets, oracles and astrologers. This ancient concept was replaced in the nineteenth century by the vocabulary of scientific determinism which said that actual beings can only function. If one knew in detail their structures and their movements, one could calculate the results (...) of their functioning with perfect precision. (shrink)

In this book Dr Walker brings together Dr William Jaffé's essays on the important and interesting work of Léon Walras, the founder of general equilibrium analysis. The essays were selected on the basis of their importance to the Walrasian literature, in that they provide information on Walras's intellectual biography with which we would otherwise be unfamiliar or they make a contribution to the interpretation and analysis of his ideas. One of Jaffé's main interests was to explain the genesis of (...) Walras's work, which he did by examining Walras's biography. Using a wide variety of sources, Jaffé pieced together an account of these matters in the belief that biography is essential for understanding the origins and development of a scientist's work. Jaffé corrected what he regarded as errors of interpretation of Walras by other writers, evaluated Walras's contributions, and indicated his significance for modern economics. The essays are informative, illuminating, and - as a result of Jaffé's scholarly and literary craftsmanship - aesthetically satisfying. (shrink)

Kant held the moral law to be an objective imperative, an entity in its own right. It carries with it prescriptive force, in parallel to other principles of pure reason, like those of logic and mathematics. Objective imperatives therefore do not derive their authority from any other source,such as common consensus or the will of God. In Objective Imperatives, Ralph C. S. Walker seeks to show that this is a highly defensible view: Kant's Categorical Imperative, properly understood, is broadly (...) right. The key to it is rationality, and not universality, which functions only as anapproximate test. Often, Kant sets the matter out badly, and most of the common objections to him can be shown to be due to misunderstandings. A morality that gives us an objective imperative does appear incompatible with the determinism to which Kant commits himself, but Walker argues that thisappearance is misleading. (shrink)

Wilhelm von Humboldt (1767-1835) is the progenitor of modern linguistics and the originator of the modern teaching and research university. However, his work has received remarkably little attention in the English-speaking world. Humboldt conceives language as the source of cognition as well as communication, both rooted in the possibility of human dialogue. In the same way, his idea of the university posits the free encounter between radically different personalities as the source of education for freedom. For Humboldt, both linguistic and (...) intellectual communication are predicated firstly on dialogue between persons, which is the prerequisite for all intercultural understanding. Linking Humboldt's concept of dialogue to his idea of translation between languages, persons, and cultures, this book shows how Humboldt's thought is of great contemporary relevance. Humboldt shows a way beyond the false alternatives of "culturalism" (the demand that a plurality of cultural and faith-based traditions be recognized as sources of ethical and political legitimacy in the modern world) and "universalism" (the assertion of the primacy of a universal culture of human rights and the renewal of the European Enlightenment project). John Walker explains how Humboldt's work emerges from the intellectual conflicts of his time and yet directly addresses the concerns of our own post-secular and multicultural age. (shrink)

Artificial devices that functionally replace internal organs are likely to be more common in the future. They are becoming more and more technologically feasible, increases in chronic diseases that can compromise various organs are anticipated, and donor organs will remain necessarily limited. More people in the future may have bodies that are partly nonorganic. How might artificial organs affect how we experience and conceptualize our bodies and how we understand the relation of the body to the experiencing, acting subject, or (...) self? Here, I focus on artificial heart devices (AHDs), including total artificial hearts (TAHs) and ventricular assist devices (VADs). While other devices, such as pacemakers and implantable cardiac defibrillators, assist the heart, I focus on devices that replace rather than assist organic function. AHDs, I argue, may have two opposing effects. On the one hand, having an AHD could alter experience, seemingly confirming that selves are shaped by the specifics of embodiment. On the other hand, AHDs are likely to encourage people to regard bodies as machines that are separable from the self. AHDs thus both confirm and undermine a body-self dualism. People with these devices may come to regard their bodies as machinelike even while having an artificial part alters their subjective experience. (shrink)

The writings of al-Ghazālī give the distinct impression that he was highly concerned with the threat the Ismailis and their doctrines posed. By his own admission, he wrote six separate treatises to refute and condemn them, most importantly his Faḍāʾiḥ al-bāṭiniyya, which he composed in the year 488h in the months prior to his renunciation of government service and departure from Baghdad. His attack focused on the doctrine known as taʿlīm, with its insistence on the unrivaled absolute authority of a (...) single infallible Imam. He had in mind the Alamut teaching by Ḥasan-i Ṣabbāḥ of a doctrine then widely advocated in the Abbasid–Seljuk East. Significantly, there is no sign of this term used in this manner in the western Fatimid domains either earlier or later. However, our knowledge of events in the career of Ḥasan and of his teachings come from much later sources and are in part legendary at best. Although the doctrine of taʿlīm was certainly implicit in Ismaili works long before, in this particular work al-Ghazālī directed his attentions squarely against a new teaching he encountered personally in his own time and place. But we know it otherwise primarily from accounts recorded much later, in particular al-Shahrastānī’s al-Milal wa-l-niḥal. (shrink)

Philosophical accounts of "action" standardly take an action to be a doing which _satisfies some description that is semantically related to the content of a propositional attitude of the subject's which _explains why that doing occurred. Causal theories of action require that the explanation in question must involve the causation of action-doings by propositional attitudes (typically intentions, volitions, or combinations of belief and desire). I argue that there are actions whose status, as such, cannot be acknowledged by any causal theory, (...) since no such theory can allow that they fulfill the satisfaction condition. (shrink)

This examination of the critical writings of Dionysius of Halicarnassus hopes to suggest two main things: First, recent arguments about the irrelevance of classical rhetoric to postmodern rhetorical criticism-conceived as a general hermeneutic of "rhetoricality", not only render the notion of "rhetorical criticism" itself increasingly problematic, but also tend to presuppose a simplified (and basically neo-Aristotelian) image of "classical rhetoric" that is unsustainable. Second an more importantly, even as we recognise that ancient rhetoric was oriented toward a discursive realm rather (...) different from that of postmodernity, and without advocating a simplistic "return to Dyonisius", nevertheless it may be argued that Dyonisius still embodies a general paradigm of "rhetorical criticism" that merits our consideration. (shrink)

Self-knowledge is a permanent and necessary aim for man. By ‘self-knowledge’ I mean the knowledge of oneself as a human being; the understanding of what it is to be a human being; the grasp of human nature as such. There are many sides to this knowledge: the sciences and social sciences, the arts, history, reflexion on day-to-day experience. Philosophy has traditionally been seen as a road that can lead towards self-knowledge. What I propose here is an essay in the philosophy (...) of self-knowledge. It is a study of one aspect of human nature among others, namely human embodiment. (shrink)

How well the Sustainable Development Goals (SDGs) are achieved will greatly influence the lives of today’s children and decisively shape the rest of the 21st century. Yet, children were largely excluded from opportunities to influence the selection of SDGs and their associated targets and indicators, and major barriers to meaningful child engagement remain. However, child-focused agencies have found that when children are intentionally enabled to participate in seeking accountability, they can influence their families, communities and governments to value their contributions (...) and increase their well-being. In furthering its strategy of building brighter futures for children, World Vision implements Citizen Voice and Action (CV&A), a strategic social accountability approach, into communities where children are severely impoverished. Drawing on empirical evidence from children’s CV&A experiences, this paper enquires into the circumstances under which children are empowered to seek accountability for SDGs. This article identifies shared processes which they and others use to strengthen children’s participation in seeking social justice through social accountability. This paper argues that children possess under-recognised research capabilities to think and reflect systemically, critique, understand, and pursue socially just and equitable outcomes conducive to the SDGs, which under the right circumstances, can influence practices, policies, laws and systems. (shrink)

In a comment on my paper, "Moral Understandings: Alternative Epistemology for a Feminist Ethics" (1989) Ralph Lindgren questions the wisdom of confrontational rhetoric in my paper and much feminist moral philosophy, and the consistency of this stance with pluralism about ethics. I defend both the rebellious rhetoric and the inclusivity of my own approach, but suggest that pluralism in moral philosophy is harder to define than Lindgren's comments suggest.

First published in 1983, _Gender, Class and Education_ is a collection of papers that formed presentations at the Westhill Sociology of Education Conference in January 1982, and is the fifth such collection to emerge from the annual conference. The conference theme, ‘Race, Class and Gender’, was not only chosen because of its topicality, but also to provide a framework for debate between educational researchers and teachers. The papers focus on the reproduction of gender relations through education and provide important insights (...) into how this process works, how it is resisted in schools and colleges, and the possibilities for radical intervention. This volume includes three teaching bibliographies on gender and education which were not presented at the conference, but were compiled specially for the book. (shrink)

In recognition of the important ethical issues posed by qualitative research in health care, the authors present key questions to aid ethical review. The purpose is to assist lay and professional members of research ethics committees in their assessment of applications involving qualitative research methods and to inform researchers intending to submit such applications for ethical approval. For the benefit of those less familiar with this type of research, the authors include an overview of different types of qualitative research, together (...) with an explanation of terms commonly used by qualitative researchers. (shrink)

There is a spectrum of identities: from the mathematical, through cases where specific criteria matter, to the complex or intuitive cases where we can recognize identity but don't know what the criteria should be. In a series of essays by senior figures in the sciences and humanities, this book examines what identity means across a number of academic disciplines. Topics range from mathematics, through the rules of recognition in biology and the law, to comprehending the individual in the visual, performing (...) and literary arts, and ultimately to notions of the philosophy of existence. Using the theme of identity to make new interdisciplinary connections, the contributors offer interested readers a glimpse into their specialist subjects and suggest new ways for students and scholars to think about identity in relation to their own work. (shrink)

First Published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.