Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.

This pamphlet contains essays by Will Herberg, C. Herman Pritchett, David Fellman, Valerie Earle and Sidney Hook on the principle of academic freedom, its implications, and its recognition by the courts. Will Herberg in the opening essay argues that the greatest threat to academic freedom is the politicization of the university, the pressure to convert the university into an agency of social and political action. Unless the university is thoroughly depoliticized and rededicated exclusively to the cause of learning and scholarship, (...) warns Herberg, it will be destroyed. C. H. Pritchett provides a useful summary of nearly all the Supreme Court's decisions bearing in some way on the academic freedom of teachers. Sidney Hook maintains that the Supreme Court has failed to make certain basic distinctions in its opinions, i.e., between the obligations of public employees and employees in private institutions; between those in professions of public trust and those who are not; and between membership in highly disciplined organizations with purposes antithetical to democratic values and membership in others which are broad in purpose and loosely bound together. From an analysis of the opinions of the Supreme Court and the nature and defense of academic freedom, Hook concludes that the court is a very uncertain protector and guide. In matters of professional ethics, it is the faculties themselves which must uphold and enforce standards of professional integrity. Their failure to do so has led to unnecessary and unwise legislative intervention. Recent events on many college and university campuses, and in particular the increasing resort to civil courts to adjudicate what are basically professional disputes, have emphasized the need for the type of discussion contained in this brief volume.--J. P. D. (shrink)

The Indiana Court of Appeals, in JKB, Sr. v. Armour Pharmaceutical Co. ), held that the state's Blood Shield Act does not protect pharmaceutical companies that produce blood-derived products from product liability suits based on injuries attributable to tainted blood supplies. Blood shield statutes help to guarantee adequate blood supplies by limiting the liability of blood banks. This holding limits the defenses available to pharmaceutical companies sued under product liability theory.The defendant, Armour Pharmaceutical, produces and sells clotting factor agents, which (...) are derived through plasmapheresis. Plasmapheresis is a costly and complex donation process through which the plasma and red blood cells of a donor's blood are separated. After separation, the process returns the red blood cells to the donor but retains the plasma. (shrink)

We isolate two abstract determinacy theorems for games of length $\omega_1$ from work of Neeman and use them to conclude, from large-cardinal assumptions and an iterability hypothesis in the region of measurable Woodin cardinals thatif the Continuum Hypothesis holds, then all games of length $\omega_1$ which are provably $\Delta_1$ -definable from a universally Baire parameter are determined;all games of length $\omega_1$ with payoff constructible relative to the play are determined; andif the Continuum Hypothesis holds, then there is a model of (...) ${\mathsf{ZFC}}$ containing all reals in which all games of length $\omega_1$ definable from real and ordinal parameters are determined. (shrink)

1. The Commentariolum Petitionis is not in the Codex Mediceus of Cicero's correspondence with his brother Quintus, but it appears at the end of the letters to Quintus in the other manuscripts. It starts in the normal manner of a letter and is, or purports to be, a collection of tips on canvassing set in the particular context of M. Cicero's consular candidature in 64: a composition of his brother Quintus. It is printed as no. 12 in Tyrrell and Purser's (...) collection of Cicero's Letters. (shrink)

Four previously unpublished chapters by Jacob Viner. The first two deal with the economic doctrines of the Christian Fathers and the Scholastics; the last two are each concerned with a particular aspect of the relationship between religious thought, economic ethics, and society. Initially conceived as part of a larger study on "Religion and Society," this volume holds some interest for the philosopher of religion because it examines the treatment by Christian theologians, both Protestant and Catholic, of topics such as private (...) property, riches and poverty, commerce, just price and economic motivation. Viner explores the roles of early Protestant theology in the rise of capitalism, with special reference to the Weber-Tawney thesis which attributes significant responsibility to Calvinist doctrine for the growth and the character of modern capitalism. The chapters on Patristic and Scholastic economic thought are particularly strong. There is a detailed examination of the economic views of Thomas Aquinas, though the author is aware that Aquinas’s influence was not a dominant one before the sixteenth century. In the final chapter Viner amasses considerable historical evidence to construct a case against Weber and his followers. In the first three chapters, Viner appears to have been partly inspired by a desire to correct the false impressions of some earlier and less friendly commentators on Catholic economic thought. Throughout, documentation is extensive. There is a rich bibliography.—J.P.D. (shrink)

Here is a deft and new introduction to Gentzen proof techniques in axiom systems and to the analysis of formal axiom systems; in short, axiomatics inside and out. Treating of deduction in propositional and predicate logic, metatheoretical problems about both set theory and its paradoxes, the book is flexibly structured for selective use as a text. Yet the discussion is unified and motivated by the concept of the axiomatic system--the history of its use and analysis, and its present practical and (...) theoretical status. Well-chosen illustrations convey an historical overview of Euclid, non-Euclidean geometers, Peano, Boole, Hilbert and Gödel.--P. D. J. (shrink)

Shepherdson [14] showed that for a discrete ordered ring I, I is a model of IOpen iff I is an integer part of a real closed ordered field. In this paper, we consider integer parts satisfying PA. We show that if a real closed ordered field R has an integer part I that is a nonstandard model of PA (or even IΣ₄), then R must be recursively saturated. In particular, the real closure of I, RC (I), is recursively saturated. We (...) also show that if R is a countable recursively saturated real closed ordered field, then there is an integer part I such that R = RC(I) and I is a nonstandard model of PA. (shrink)

It is shown that the determinacy of $G_{\delta \sigma }$ games of length $\omega ^2$ is equivalent to the existence of a transitive model of ${\mathsf {KP}} + {\mathsf {AD}} + \Pi _1\textrm {-MI}_{\mathbb {R}}$ containing $\mathbb {R}$. Here, $\Pi _1\textrm {-MI}_{\mathbb {R}}$ is the axiom asserting that every monotone $\Pi _1$ operator on the real numbers has an inductive fixpoint.

Compelled by recent public and politicized cases in which withdrawal of nutrition and hydration were at issue, this essay examines recent Church statements and argues that the distinction between private and public forms of human life is being lost. Effacing the distinction between the sphere of the home (oikos), where the maintenance of life (zoē) occurs, and the city (polis), where political and public life (bios) occurs, may have unforeseen and unwanted consequences. Through their well-intentioned efforts to preserve the sanctity (...) of life, certain bishops and the Congregation for the Doctrine of the Faith have unfortunately brought political considerations into the home, taking decision-making authority away from those most intimately related to the patient. Thus, the question of removing nutrition and hydration in the case of patients such as Schiavo and Englaro becomes politicized and abstract, in contrast with the Church's previous positions on the importance of proportionate means in the maintenance of life, local decision making, and its recognition of life as a penultimate end. (shrink)