In July 1997, the voting representatives at the National Consensus Conference on Bioethics in Health Research voted unanimously to adopt the proposed Guidelines for the Conduct of Health Research Involving Human Subjects in Uganda. This vote represented the culmination of a three-year journey towards the development of a coherent and cohesive framework for the ethical review of health research involving human subjects in Uganda.Attendees at the NCC included both voting representatives and non-voting participants. Voting representatives had been designated by the (...) institutional entity with which they were affiliated to represent that entity at the NCC and to voice the concerns and opinions of the entity and its constituents. (shrink)

Researchers, scientists, and physicians in Uganda have become increasingly aware of the need to develop a systematic approach to reviewing bio-medical research conducted in their country. Much of this awareness and their concern stems from Uganda's high seroprevalence of human immunodeficiency virus and the consequent large influx of research monies and HIV researchers from developed countries, including the United States and Great Britain.We report on the proceedings of a five-day symposium on bioethical principles governing clinical trials, which convened in Jinja, (...) Uganda in September 1994. The thirteen male and female workshop participants included representatives from the Uganda Ministry of Health, Makerere University, the Uganda AIDS Commission, Uganda's National Council of Science and Technology, and the National Chemotherapeutic Laboratory. These representatives included ethicists, physicians, researchers, and pharmacists, all of whom have conducted research themselves. Initial workshop sessions focused on the history of human experimentation and the development of protections for human participants in medical research, both in the United States and internationally. (shrink)

Over the last 30 years, representationalist and dynamicist positions in the philosophy of cognitive science have argued over whether neurocognitive processes should be viewed as representational or not. Major scientific and technological developments over the years have furnished both parties with ever more sophisticated conceptual weaponry. In recent years, an enactive generalization of predictive processing – known as active inference – has been proposed as a unifying theory of brain functions. Since then, active inference has fueled both representationalist and dynamicist (...) campaigns. However, we believe that when diving into the formal details of active inference, one should be able to find a solution to the war; if not a peace treaty, surely an armistice of a sort. Based on an analysis of these formal details, this paper shows how both representationalist and dynamicist sensibilities can peacefully coexist within the new territory of active inference. (shrink)

Bayesian approaches to legal reasoning propose causal models of the relation between evidence, the credibility of evidence, and ultimate hypotheses, or verdicts. They assume that legal reasoning is the process whereby one infers the posterior probability of a verdict based on observed evidence, or facts. In practice, legal reasoning does not operate quite that way. Legal reasoning is also an attempt at inferring applicable rules derived from legal precedents or statutes based on the facts at hand. To make such an (...) inference, legal reasoning follows syllogistic logic and first order transitivity. This paper proposes a Bayesian model of legal syllogistic reasoning that complements existing Bayesian models of legal reasoning using a Bayesian network whose variables correspond to legal precedents, statutes, and facts. We suggest that legal reasoning should be modelled as a process of finding the posterior probability of precedents and statutes based on available facts. (shrink)

The first English translation of the major political works of Benjamin Constant (1767-1830), one of the most important of the French political figures in the aftermath of the revolution of 1789, and a leading member of the liberal opposition to Napoleon and later to the restored Bourbon monarchy. The texts included in this volume are widely regarded as one of the classic formulations of modern liberal doctrine.

Drawing on affective sciences, I argue that normally elicited emotions involve a component—the appraisal process—that represents evaluative properties unconsciously. More specifically, I argue that, given a substantial agreement in affective sciences about what emotions are, given broadly shared definitions of representation, evaluative properties, and unconsciousness, given how appraisals are conceptualized by most (neuro)psychological theories of emotion, and given empirical evidence about affective states elicited by stimuli perceived unconsciously, we are led to conclude that normally elicited emotions involve a component that (...) represents evaluative properties unconsciously. In the last section, I assess which philosophical theories of emotions are in contradiction with my conclusion, ask whether it implies that emotions represent evaluative properties consciously as well, and discuss how it relates to the debate on unconscious emotions. (shrink)

La polémica Constant-Kant tuvo lugar cuando Inmanuel Kant replico directamente a una observación crítica formulada por Constant en su panfleto Des Réactions Politiques. El tema sobre el que se debatía era la existencia de un deber incondicionado de decir siempre y en cualquier situación la verdad. Frente a las tesis del imperativo universal moral de la verdad del filósofo de Koënisberg, Constant opone los ejemplos concretos de situaciones en las que decir la verdad puede equivaler a hacer (...) el mal. Gabriel Albiac no explica en el Estudio introductorio que precede a la edición de los textos completos de la querella, cuanto anticipan las tesis que aquí se debaten, los problemas que generará el totalitarismo y el terror en el mundo de las ideologías holistas. Pero más allá de las consecuencias que pueden deparar las reflexiones en este libro relativas al derecho a decir y exigir la verdad - que es un de los postulados de la sacralización de la teología operada a partir del Renacimiento y de la Ilustración-, la polémica Constant/ Kant oculta otro segundo debate sobre el valor de los principios, la forma de construirlos y su eficacia para regir y explicar la realidad que se demuestra de excepcional interés en un siglo como el XXI, desbordado por su incapacidad de comprender los hechos que todos los días ofrece un mundo empírico en continua efervescencia, debido a la carencia de un sistema de categorías de principio generalmente aceptados que pueda servir de referente para unificar la multiplicidad de lo singular. En esta polémica que surge entre, un gran filósofo consagrado, que no tuvo reparo en salir al quite de un argumento que consideraba digno de réplica, y un joven aventurero dotado de extraordinaria inteligencia que iba a demostrarse capaz de comprender el mundo en que iniciaba su singladura, están contenidos en ciernes los supuestos básicos de alguno de lo problemas centrales de nuestra difícil postmodernidad. (shrink)

In evolutionary biology, niche construction is sometimes described as a genuine evolutionary process whereby organisms, through their activities and regulatory mechanisms, modify their environment such as to steer their own evolutionary trajectory, and that of other species. There is ongoing debate, however, on the extent to which niche construction ought to be considered a bona fide evolutionary force, on a par with natural selection. Recent formulations of the variational free-energy principle as applied to the life sciences describe the properties of (...) living systems, and their selection in evolution, in terms of variational inference. We argue that niche construction can be described using a variational approach. We propose new arguments to support the niche construction perspective, and to extend the variational approach to niche construction to current perspectives in various scientific fields. (shrink)

Il volume contiene la traduzione della Prefazione e del Libro I dell'opera di Benjamin Constant (1767-1830) - teorico della democrazia liberale, storico e filosofo nel dominio delle religioni, romanziere, politico che debutta nella Rivoluzione francese, matura sotto il regime napoleonico, invecchia durante la monarchia della Restaurazione - De la Religion, pubblicata in cinque tomi tra il 1824 e il 1831. Corredato di un ampio saggio introduttivo del curatore, il libro colma una lacuna della cultura filosofica italiana, ossia l'assenza di (...) una traduzione dell'opera religiosa di Constant, di cui viene proposta la parte iniziale contenente l'introduzione generale alla vasta storia comparata delle religioni antiche - dal feticismo al politeismo - che compone il lavoro constantiano. "Opera capitale per intendere compiutamente il Constant" - scrive Fulvio Tessitore nella Presentazione - e, ancor più, l'età nevralgica in cui essa apparve e della quale è uno dei vertici letterari e teoretici--OCLC. (shrink)

Heloise and Discussion about Love. This chapter examines the significance of the early love affair of Abelard and Heloise. It argues that this relationship was not simply a matter of fornication portrayed by Abelard in the Historia calamitatum. Drawing on the Epistolae duorum amantium, which I argue is a record of an early exchange between Abelard and Heloise, I explain that Heloise wanted to apply Ciceronian ideals of friendship to love between a man and a woman. At her request, Abelard (...) did endeavor to define friendship in terms based on Cicero, but he never developed her interest in true friendship as not seeking any personal reward. His love letters are more strongly influenced by a passionate ideal of love, inspired by the poetry of Ovid. (shrink)

El 3 de enero de 1889, en Turín, se produjo la primera crisis que callaría a aquel que se llamaba a sí mismo Dionisos o el Crucificado, o ambos a la vez. Ya en Basilea, a Nietzsche se le había diagnosticado "parálisis progresiva". En Jena, los médicos supusieron una infección sifilítica que se remontaba hacia 1866. Paradójicamente, a fines del mismo mes de enero se publicaba El ocaso de los ídolos y en la primavera de ese mismo año, cuando Nietzsche (...) parecía haberse olvidado de todo lo referente a su obra y de sí mismo, se publicaba Nietzsche contra Wagner. (shrink)

We argue that political propaganda is a negative phenomenon, against a recent strain of philosophical theorizing that argues that political propaganda can sometimes be neutral or even positive. After an exploration of the sense and connotation of the word ‘propaganda’ in ordinary use and in the scholarly literature, we discuss Ross’s (2002) account of propaganda as an epistemically defective form of political communication. We claim that, with some refinements, it is an explanatorily useful analysis. We then assess two prominent attempts (...) that aim at classifying legitimate cases of public communication as cases of propaganda, namely Ross’s (2013) revision of her previous model, and Stanley’s (2015) influential account. We show that some of the cases in contention are problematic and that the arguments the authors offer for classifying other non-problematic cases as propaganda are inconclusive. We also argue that the idea of considering legitimate public communication as propaganda is unmotivated. (shrink)

Faith, Sacraments and Charity. This chapter considers Abelard’s lectures or sententie on faith, sacraments and charity in which he formulated a synthetic vision of theology, recorded by students. It also reviews Abelard’s theology through the perspective of one of his foremost critics, Hugh of St. Victor, in the De sacramentis. While Abelard was always known as a logician, he emerged in the 1130s as one of the most original theologians and theorist of ethics of his generation. The chapter considers the (...) evolution of the Theologia ‘Scholarium’ in the context of his teaching in the schools. It concludes by looking at the evolution of his thinking about the distinction between vice and sin in his Ethics or Scito teipsum, arguing that here he is responding to a longstanding concern of Heloise. (shrink)

The Early Years: Roscelin of Compiègne and William of Champeaux. This chapter examines Abelard’s intellectual debt to both the vocalist theories of Roscelin of Compiègne and William of Champeaux’s teaching about dialectic in shaping his philosophical nominalism. By looking at the earliest records of Abelard’s teaching of dialectic and glosses on Aristotle, Porphyry and Boethius, it observes how students identified him as an iconoclast teacher, who quickly provoked laughter by the examples that he chose. It traces how Abelard’s early conflict (...) with his teachers laid the foundation for the subsequent difficulties he would experience in his career. (shrink)

Heloise and the Paraclete. This chapter considers Abelard’s decision to entrust his foundation of the Paraclete to Heloise and his writing of the Historia calamitatum in 1132–33, as well as Heloise’s reaction to this autobiographical narrative. It examines the impact of Heloise’s arguments about their past relationship and about the religious life for women on Abelard’s writings for the Paraclete. It also considers Abelard’s poetic laments in the light of Heloise’s interest in the human side of the Bible.

Cognitive niche construction is the process whereby organisms create and maintain cause–effect models of their niche as guides for fitness influencing behavior. Extended mind theory claims that cognitive processes extend beyond the brain to include predictable states of the world. Active inference and predictive processing in cognitive science assume that organisms embody predictive (i.e., generative) models of the world optimized by standard cognitive functions (e.g., perception, action, learning). This paper presents an active inference formulation that views cognitive niche construction as (...) a cognitive function aimed at optimizing organisms' generative models. We call that process of optimization extended active inference. (shrink)

Transposons are well‐known architects of genetic change but their role in insecticide resistance has, until recently, only been speculated upon.1 Transposon insertion, or transposon‐mediated transposition, could alter either metabolic enzymes capable of degrading pesticides or could change the functionality of insecticide targets. The recent work of Aminetzach and coworkers2 suggests an exciting alternative, that transposon insertion can cause resistance by altering gene product function. This hypothesis is discussed in the light of other examples in which transposons have been implicated in (...) insecticide resistance. BioEssays 28:6–8, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

Dans ce texte, je me propose d’appliquer aux œuvres d'arts visuels, et en particulier à Baptism I de Michael Rampa, une théorie sur la nature de l’art, la théorie des qualités quaternaires. Selon celle-ci, l'art existe en vertu de qualités quaternaires, qui consistent en les créations ostensives de propriétés évaluatives perçues.

L'éloge funèbre chez les Romains.--Le philosophe Carnéade à Rome.--Les consolations dans l'antiquité.--L'examine de conscience chez les anciens.--Un chrétien devenu paĭen.--Un paĭen devenu chrétien.

For María Zambrano all forms of knowledge are articulated from tradition, because what is essential is located in the past, as if it were a question of a substratum per se which is always known and transmitted. Wisdom increases by accumulation: knowledges add up, they become part of a ..