Results for 'Colin Sharpe'

943 found
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  1.  19
    Noggin — the neural inducer or a modifier of neural induction?Colin Sharpe - 1994 - Bioessays 16 (3):159-160.
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  2.  24
    Wnt signalling: a theme with nuclear variations.Colin Sharpe, Nicola Lawrence & Alfonso Martinez Arias - 2001 - Bioessays 23 (4):311-318.
    Wnt proteins are involved in a large number of events during development and disease. The crucial element in the transduction of the signal elicited by Wnt is the state and activity of β-catenin. There are two pools of β-catenin, one associated with cadherins at the cell surface and a soluble one in the cytolasm, whose state and concentration are critical for Wnt signalling. In the absence of Wnt, the cytoplasmic pool is low due to targetted degradation of β-catenin. Upon Wnt (...)
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  3.  17
    Regional neural induction in Xenopus laevis.Colin R. Sharpe - 1990 - Bioessays 12 (12):591-596.
    During development of the Xenopus embryo, the formation of the nervous system depends on an inductive interaction between mesoderm and ectoderm. The result is a neural tube that is regionally differentiated along the anterior–posterior axis from forebrain to spinal cord (Fig. 1). The discovery of genes whose transcripts can be used as molecular markers for different regions of the nervous system has permitted reassessment of the existing theories of neural tissue formation. Although the neural inducing molecules remain elusive, the mechanism (...)
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  4.  15
    Philosophical provocations: 55 short essays.Colin McGinn - 2017 - Cambridge, Massachusetts: MIT Press.
    Pithy, direct, and bold: essays that propose new ways to think about old problems, spanning a range of philosophical topics. In Philosophical Provocations, Colin McGinn offers a series of short, sharp essays that take on philosophical problems ranging from the concept of mind to paradox, altruism, and the relation between God and the Devil. Avoiding the usual scholarly apparatus and embracing a blunt pithiness, McGinn aims to achieve as much as possible in as short a space as possible while (...)
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  5.  27
    R. A. Sharpe (1935–2006).Colin Lyas - 2006 - British Journal of Aesthetics 46 (4).
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  6.  36
    R. A. Sharpe, "Contemporary Aesthetics".Colin Lyas - 1984 - Philosophical Quarterly 34 (137):511.
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  7.  12
    Sacrifice and the Public Sphere.Colin Jager - 1998 - Contagion: Journal of Violence, Mimesis, and Culture 5 (1):57-73.
    In lieu of an abstract, here is a brief excerpt of the content:SACRIFICE AND THE PUBLIC SPHERE Colin Jager University ofMichigan The Inscription on the Memorial to Irish Freedom in Parnell Square, Dublin, reads: "O generations of freedom, remember us, the generations of the vision." The irony, of course, is that the generations of freedom to whom the inscription is addressed have yet to be born. Or rather: they/we are partly a generation of freedom, while remaining also and of (...)
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  8. A Decaying Carcass? Mary Astell and the Embodied Self.Colin Chamberlain - manuscript
    Mary Astell (1666-1731) relies on a Cartesian account of the self to argue that both men and women are essentially thinking things and, hence, that both should perfect their minds or intellects. In offering such an account of the self, Astell might seem to ignore the inescapable fact that we have bodies. I argue that Astell accommodates the self’s embodiment along two main dimensions. First, she tempers her sharp distinction between mind and body by insisting on their union. The mind (...)
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  9. Preparing for our enhanced future.Colin Farrelly - manuscript
    (forthcoming) Journal of Medical Licensure and Discipline. Rapid advances in human genetics raise the prospect that one day we may be able to develop genetic enhancements to promote a diverse range of phenotypes (e.g. health, intelligence, behaviour, etc.). Perhaps the biggest challenge that genetic enhancements pose for medical practitioners is that they will compel us to re-think a good deal of the conventional wisdom of the status quo. Radical enhancements are likely to have this affect for a variety of reasons. (...)
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  10.  33
    A Realist Theory of Science.R. A. Sharpe - 1976 - Philosophical Quarterly 26 (104):284-285.
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  11.  18
    Scientific Realism and the Plasticity of Mind.R. A. Sharpe - 1980 - Philosophical Quarterly 30 (120):268-269.
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  12. Animalism and Person Essentialism.Kevin W. Sharpe - 2015 - Metaphysica 16 (1):53-72.
    Animalism is the view that human persons are human animals – biological organisms that belong to the species Homo sapiens. This paper concerns a family of modal objections to animalism based on the essentiality of personhood (persons and animals differ in their persistence conditions; psychological considerations are relevant for the persistence of persons, but not animals; persons, but not animals, are essentially psychological beings). Such arguments are typically used to support constitutionalism, animalism’s main neo-Lockean rival. The problem with such arguments (...)
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  13.  53
    In the Crosshairs of the Fourfold: Critical Thoughts on Aleksandr Dugin’s Heidegger.Matthew Sharpe - 2020 - Critical Horizons 21 (2):167-187.
    In Part 1, we situate Dugin’s interpretation of Heidegger in relation to the better known, broadly left-liberal approaches to interpreting Heidegger’s thought, stressing Dugin’s unusual focus on the German thinker’s “middle” or Nazi-era texts, and showing how this periodizing optic affects Dugin’s culminating reading of Sein und Zeit and its key axiological notion of authenticity (Part 1). Part 2 examines Dugin’s appropriation of Heidegger’s radically pessimistic, trans-epochal critique of Western thought, centring around his striking reading of the esoteric notion of (...)
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  14. Comparative Religion: A History.Eric J. Sharpe - 1989 - Philosophy East and West 39 (3):362-364.
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  15.  24
    Between Usual and Crisis Phases of a Public Health Emergency: The Mediating Role of Contingency Measures.David Alfandre, Virginia Ashby Sharpe, Cynthia Geppert, Mary Beth Foglia, Kenneth Berkowitz, Barbara Chanko & Toby Schonfeld - 2021 - American Journal of Bioethics 21 (8):4-16.
    Much of the sustained attention on pandemic preparedness has focused on the ethical justification for plans for the “crisis” phase of a surge when, despite augmentation efforts, the demand for life...
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  16.  39
    Pierre Hadot, Albert Camus and the orphic view of nature.Matthew Sharpe - 2020 - Continental Philosophy Review 54 (1):17-39.
    Albert Camus repeatedly denied the label “existentialist,” and pointed to his formative experiences of natural beauty and his early introduction to classical Greek thought and culture as determinative of his philosophy. Pierre Hadot, famous for his post-1970 work on philosophy as a way of life in classical antiquity, continued throughout his life to work on the history of Western conceptions of nature. In Le voile d’Isis, Hadot excavated a second strain of Western attitudes towards nature, alongside the instrumental or “Promethean” (...)
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  17.  81
    When the Aim is Practical Wisdom.Barry Sharpe - 2014 - Teaching Ethics 14 (2):123-133.
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  18.  88
    Camus and the Virtues.Matthew Sharpe - 2017 - Philosophy Today 61 (3):679-708.
    Albert Camus can be meaningfully read as an agent-focussed virtue ethicist, as David Sherman has suggested. Yet moving far beyond Sherman’s version of this claim, we show here how Camus accepts what are four definitive parameters of the classical authors’ conception of the virtues—the last of which takes him beyond today’s recognised “virtue ethicists.” Firstly, he understands the virtues as lasting, beneficent dispositions to think, feel, and act in certain ways. Secondly, he conceives the virtues as mastering the untethered passions: (...)
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  19.  15
    An Introduction to the Philosophy of Science.R. A. Sharpe - 1970 - Philosophical Quarterly 20 (78):90-90.
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  20.  61
    How It's Not the Chrisippus You Read: On Cooper, Hadot, Epictetus, and Stoicism as a Way of Life.Matthew Sharpe - 2014 - Philosophy Today 58 (3):367-392.
    This article challenges John M. Cooper’s reading of ancient Stoicism as a way of life, one which sets its back against Pierre Hadot’s notion that Stoicism could have philosophically advocated regimens of non-cognitive practices of the kind documented by Hadot. Part 1 examines Arrian’s Discourses, following A. A. Long in seeing in this text Arrian’s portrait of Epictetus as a philosophical persona: one bringing together the different virtues of Socrates, Diogenes, and Zeno. Part 2 then examines Epictetus’s Handbook , seeing (...)
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  21.  26
    Fearless?: Peter Weir, The Sage, and the Fragility of Goodness.Matthew Sharpe - 2017 - Philosophy and Literature 41 (1):136-157.
    Who, if I cried out, would hear me among the Angelic Orders? And even if one were to suddenly take me to its heart, I would vanish into its stronger existence. For beauty is nothing but the beginning of terror, that we are still able to bear, and we revere it so, because it calmly disdains to destroy us...."So what are you telling me, there's no God, but there's you?"Peter Weir's film Fearless appeared in 1993 to critical acclaim and middling (...)
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  22.  47
    Guests, Hosts, Strangers: Far From Men and Camus' Algerians.Matthew Sharpe - 2017 - Film-Philosophy 21 (3):326-348.
    I argue that David Oelhoffen's 2014 film Far From Men, while departing from the letter of Camus' 1957 story, “The Guest/Host”, does remarkable cinematic justice to its spirit. Oelhoffen's Daru and the Arab character Mohamed, it is suggested, represent embodiments of Camus’ idealised Algerian “first men”, in the vision Camus was developing in Le Premier Homme at the time of his death in January 1960. Part 1 frames the film in light of Camus’ “The Guest/Host”, and Part 2 frames Camus’ (...)
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  23.  34
    Toula Nicolocapoulos, The Radical Critique of Liberalism: In Memory of a Vision.Matthew Sharpe - 2009 - Critical Horizons 10 (3):430-435.
  24. Stoic virtue ethics.Matthew Sharpe - 2014 - In S. van Hooft, N. Athanassoulis, J. Kawall, J. Oakley & L. van Zyl, The handbook of virtue ethics. Durham: Acumen Publishing.
  25.  80
    Dennett's journey towards Panpsychism.R. A. Sharpe - 1989 - Inquiry: An Interdisciplinary Journal of Philosophy 32 (2):233-240.
  26.  26
    Home to men’s business and bosoms: philosophy and rhetoric in Francis Bacon’s Essayes.Matthew Sharpe - 2019 - British Journal for the History of Philosophy 27 (3):492-512.
    ABSTRACTThis article claims that today’s reading of Francis Bacon’s Essayes as a solely literary text turns upon philosophers’ having largely lost access to the renaissance culture which Bacon inherited, and the renaissance debates about the role of rhetoric in philosophy in which Bacon participated. The article has two parts. Building upon Ronald Cranes’ seminal contribution on the place of the Essayes in Bacon’s ‘great instauration’, Part 1 examines how the subjects of Bacon’s Essayes need to be understood as Baconian contributions (...)
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  27.  23
    Modulation of attention and action in the medial prefrontal cortex of rats.Melissa J. Sharpe & Simon Killcross - 2018 - Psychological Review 125 (5):822-843.
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  28.  32
    The Topics Transformed: Reframing the Baconian Prerogative Instances.Matthew Sharpe - 2018 - Journal of the History of Philosophy 56 (3):429-454.
    john c. briggs has commented that "The reading of Baconian texts resembles the Baconian reading of nature, for in both the interpreter must discover a clue to the labyrinth."1 This thought certainly applies to the Praerogatiuis Instantiarum and their precise role in Bacon's Novum Organum.2 These instances occupy thirty-one of the fifty-two sections of Novum Organum II, whereas only nine are devoted to the much better-known work of the tabulation of affirmative, negative and deviating instances, and one long section on (...)
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  29. Reduction without reductionism: A defence of Nagel on connectability.Colin Klein - 2009 - Philosophical Quarterly 59 (234):39-53.
    Unlike the overall framework of Ernest Nagel's work on reduction, his theory of intertheoretic connection still has life in it. It handles aptly cases where reduction requires complex representation of a target domain. Abandoning his formulation as too liberal was a mistake. Arguments that it is too liberal at best touch only Nagel's deductivist theory of explanation, not his condition of connectability. Taking this condition seriously gives a powerful view of reduction, but one which requires us to index explanatory power (...)
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  30.  38
    Medical Ethics in the Courtroom: A Reappraisal.V. A. Sharpe & E. D. Pellegrino - 1997 - Journal of Medicine and Philosophy 22 (4):373-379.
    Following up on a 1989 paper on the subject, this essay revisits the question of ethical expertise in the court room. Informed by recent developments in the use of ethics experts, the authors argue 1) that the adversarial nature of court proceedings challenges the integrity of the ethicist's pedagogical role; 2) that the use of ethics experts as normative authorities remains dubious; 3) that clarification of the State's interest in “protecting the ethical integrity of the medical profession” is urgently required; (...)
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  31.  13
    The Moral Case Against Religious Belief.R. A. Sharpe - 1997 - Scm Press.
    This short book is intended to be read in an evening or even a sitting, though it provokes reflections that will go on for far longer. Professor Sharpe is a philosopher and writes as a post-Christian. He does not believe in God for moral reasons and argues that in some ways morality is corrupted by religion.
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  32.  24
    Zizek and Politics: A Critical Introduction.Matthew Sharpe & Geoff M. Boucher - 2010 - Edinburgh University Press.
    In Zizek and Politics, Geoff Boucher and Matthew Sharpe go beyond standard introductions to spell out a new approach to reading Zizek, one that can be highly critical as well as deeply appreciative. They show that Zizek has a raft of fundamental positions that enable his theoretical positions to be put to work on practical problems. Explaining these positions with clear examples, they outline why Zizek's confrontation with thinkers such as Derrida, Foucault and Deleuze has so radically changed how (...)
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  33.  33
    Developmental genetics and early hominid craniodental evolution.Melanie A. McCollum & Paul T. Sharpe - 2001 - Bioessays 23 (6):481-493.
    Although features of the dentition figure prominently in discussions of early hominid phylogeny, remarkably little is known of the developmental basis of the variations in occlusal morphology and dental proportions that are observed among taxa. Recent experiments on tooth development in mice have identified some of the genes involved in dental patterning and the control of tooth specification. These findings provide valuable new insight into dental evolution and underscore the strong developmental links that exist among the teeth and the jaws (...)
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  34.  22
    Dogs, distemper and Paget's disease.Andrew P. Mee & Paul T. Sharpe - 1993 - Bioessays 15 (12):783-789.
    The cause of Paget's disease is still unknown, despite many years of intensive study. During this time, evidence has sporadically emerged to suggest that the disease may result from a slow viral infection by one or more of the Paramyxoviruses. More recently, epidemiologic and molecular studies have suggested that the canine paramyxovirus, canine distemper virus, is the virus responsible for the disease. If true, then along with rabies, this would be a further example of a canine virus causing human disease. (...)
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  35. Total colour blindness: an introduction.Lindsay T. Sharpe & Knut Nordby - 1990 - In R. F. Hess, L. T. Sharpe & K. Nordby, Night Vision: Basic, Clinical and Applied Aspects. Cambridge University Press. pp. 253--289.
     
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  36. Critique as technology of the self.Matthew Sharpe - 2005 - Foucault Studies 2:97-116.
    This inquiry is situated at the intersection of two enigmas. The first is the enigma of the status of Kant's practice of critique, which has been the subject of heated debate since shortly after the publication of the first edition of The Critique of Pure Reason. The second enigma is that of Foucault's apparent later 'turn' to Kant, and the label of 'critique', to describe his own theoretical practice. I argue that Kant's practice of 'critique' should be read, after Foucault, (...)
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  37.  56
    Hearing as.R. A. Sharpe - 1975 - British Journal of Aesthetics 15 (3):217-225.
  38.  21
    II. The business of anthologies.R. A. Sharpe - 1970 - Inquiry: An Interdisciplinary Journal of Philosophy 13 (1-4):468-474.
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  39.  12
    Introduction: European Thought, After the Deluge.Matthew Sharpe & Rory Jeffs - 2017 - In Matthew Sharpe, Rory Jeffs & Jack Reynolds, 100 years of European philosophy since the Great War: crisis and reconfigurations. Cham: Springer.
    The Great War, as it was known until 1939, set in chain a series of catastrophes and crises that have largely defined the long twentieth century: economic, political, cultural, and metaphysical. Philosophy was not unaffected, either within academe, or more widely. Nearly each of the major philosophical movements, from analytic philosophy through to post-structuralism, was directly or indirectly formed in response to the civilizational crisis the Great War inaugurated, and different perceptions of its causes and significance. This chapter surveys the (...)
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  40. Language is a form of experience: Reconciling classical pragmatism and neopragmatism.Colin Koopman - 2007 - Transactions of the Charles S. Peirce Society 43 (4):694 - 727.
    : The revival of philosophical pragmatism has generated a wealth of intramural debates between neopragmatists like Richard Rorty and contemporary scholars devoted to explicating the classical pragmatism of John Dewey and William James. Of all these internecine conflicts, the most divisive concerns the status of language and experience in pragmatist philosophy. Contemporary scholars of classical pragmatism defend experience as the heart of pragmatism while neopragmatists drop the concept of experience in favor of a thoroughly linguistic pragmatism. I argue that both (...)
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  41.  28
    Selections from S the naked and the undead.Cynthia Freeland - manuscript
    The laboratory creation scene in Branagh’s film is brilliant….Even more frenzied and overwrought than Whale’s, Branagh’s creation scene is filmed with dozens of quick cuts, each shot full of movement across the frame. Victor races along his attic hall, cape flying before he discards it to appear bare-chested and vigorous. While pulleys move, bottles clank, and blue volts of electricity rise in glass Tesla tubes, the naked body on the gurney is raised into a copper vat. Electric eels dispense their (...)
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  42.  55
    The idea of reparation.Susan Sharpe - 2007 - In Gerry Johnstone & Daniel W. Van Ness, Handbook of Restorative Justice. Taylor & Francis. pp. 24--40.
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  43.  15
    5. Critical Problematization in Foucault and Deleuze: The Force of Critique without Judgment.Colin Koopman - 2016 - In Nicolae Morar, Thomas Nail & Daniel Warren Smith, Between Deleuze and Foucault. Edinburgh University. pp. 87-119.
  44.  34
    Atoms and Avatars: Virtual Worlds as Massively-Multiplayer Laboratories.Colin Milburn - 2008 - Spontaneous Generations 2 (1):63.
    Nanotechnology thrives in the realm of the virtual. Throughout its history, the field has been shaped by futuristic visions of technological revolution, hyperbolic promises of scientific convergence at the molecular scale, and science fiction stories of the world rebuilt atom by atom. Even today, amid the welter of innovative nanomaterials that increasingly appear in everyday consumer products—the nanoparticles enhancing our sunscreens, the carbon nanotubes strengthening our tennis rackets, the antimicrobial nano-silver lining our socks, the nanofilms protecting our wrinkle-free trousers—the public (...)
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  45.  10
    Nanowarriors: Military Nanotechnology and Comic Books.Colin Milburn - 2005 - Intertexts 9 (1):77-103.
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  46.  35
    The unexpected examination.R. A. Sharpe - 1965 - Mind 74 (294):255.
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  47.  36
    Sustaining Resources for Homo Martis: The Potential Application of Synthetic Biology for the Settlement of Mars.Martin Braddock & Rauf Sharpe - 2022 - Studia Humana 11 (1):1-16.
    The recent success of the Mars 2020 project and the high quality images relayed back to Earth have provided further impetus and expectations for human missions to Mars. To support space agency and private enterprise plans to establish a sustainable colony on Mars in the 2030s, synthetic biology may play a vital role to enable astronaut self-sufficiency. In this review, we describe some aspects of where synthetic biology may inform and guide in situ resource utilisation strategies. We address the nature (...)
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  48.  25
    Science, bioethics, and the public interest: ▪On the need for transparency▪.Virginia A. Sharpe - 2002 - Hastings Center Report 32 (3):23-26.
    As in science, so in bioethics: if prohibiting conflicts of interest is not feasible, rigorous requirements for disclosure can at least manage them.
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  49.  21
    Goals and Self-Efficacy Beliefs During the Initial COVID-19 Lockdown: A Mixed Methods Analysis.Laura Ritchie, Daniel Cervone & Benjamin T. Sharpe - 2021 - Frontiers in Psychology 11.
    This study aimed to capture how the coronavirus disease 2019 crisis disrupted and affected individuals’ goal pursuits and self-efficacy beliefs early during the lockdown phase of COVID-19. Participants impacted by lockdown regulations accessed an online questionnaire during a 10-day window from the end of March to early April 2020 and reported a significant personal goal toward which they had been working, and then completed quantitative and qualitative survey items tapping self-efficacy beliefs for goal achievement, subjective caring about the goal during (...)
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  50.  38
    The Interdependence of Intra- and Inter-Subjectivity in Constructivist Institutionalism.Colin Hay - 2017 - Critical Review: A Journal of Politics and Society 29 (2):235-247.
    ABSTRACTOscar Larsson’s sympathetic critique of constructivist institutionalism calls for a clarification of my understanding of subjectivity, inter-subjectivity, and their mutual interdependence. That interdependence lies at the heart of any genuinely constructivist approach, just as the interdependence of structure and agency lies at the heart of any genuinely institutionalist approach. As such, I reject the charge of subjectivism just as I would that of voluntarism. Building on the social ontology of Berger and Luckmann, we can distinguish between subjectivity and intra-subjectivity and (...)
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