Genome‐wide identification of transcription factor binding sites with the ChIP‐seq method is an extremely important scientific endeavor − one that should ideally be performed for every transcription factor in as many cell types as possible. A major hurdle on the way to this goal is the necessity for a specific, ChIP‐grade antibody for each transcription factor of interest, which is often not available. Here, we describe CETCh‐seq, a recently published method utilizing genome engineering with the CRISPR/Cas9 system to circumvent the (...) need for a specific antibody. Using the CETCh‐seq method, targeted genomic editing results in an epitope‐tagged transcription factor, which is recognized by a well‐characterized, standard antibody, efficacious for ChIP‐seq. We have used CETCh‐seq in human cancer cell lines as well as mouse embryonic stem cells. We find that roughly 60% of transcription factors tagged using CETCh‐seq produce a high quality ChIP‐seq map, a significant improvement over traditional antibody‐based methods. (shrink)

Christopher Partridge, The Re-Enchantment of the West. Volume II. Alternative Spiritualities, Sacralization, Popular Culture, and Occulture T&T Clark, New York, 2005.

. . . I should like to ask some questions about a particular obviousness: that lie in English means both to say something false while knowing it to be so, and to rest or to be in a prostrate or recumbent position. A pun, after all, is likely to be a compacting or constellating of language and literature, of social and cultural circumstance. There is potency in the pun or the suggestive homophone. "Miscegenation" must be a bad thing. Does it (...) not confess that it is a mis-something? Similarly, "What's good for General Motors is good for America" presses us to concede the claim made by general ; a quite other route would have to be taken if the language were to press us to concede that "What's good for A.B. Dick is good for America." Again, the political energy of a strike profits from the crisp energy of the word, a word—strike—which accords to an enterprise which is one of withdrawal, passivity, and attrition the associations of something which is on the offensive, active, and speedy. Christopher Ricks, professor of English literature at the University of Cambridge, is the author of Milton's Grand Style, Tennyson, Poems and Critics, and Keats and Embarrassment. He is also editor of the journal Essays in Criticism. (shrink)

My intentions here are fourfold. First, I aim to provide an overview of the ethics-related activities that are regularly taking place in our universities today, looking initially at teaching in particular, and then considering the broader picture. Second, I want to consider what professional ethics does and should involve, and to raise certain questions about the relation between its concerns and the sorts of teaching the university can legitimately provide. Third, the current emphasis in professional ethics with the virtues, a (...) focus borrowed from academic philosophy is, I’ll argue, not altogether well suited to what is needed from professional activities and expertise. I end, fourth, with some suggestions, first, as to how a compromise moral theory might better suit the needs of the professions and, second, how professionals might best involve themselves in ethical debate and decision-making. (shrink)

In the Name of Friendship: Deguy, Derrida and "Salut"centres on the relationship between poet Michel Deguy and philosopher Jacques Derrida. Translations of two essays, "Of Contemporaneity" by Deguy and "How to Name" by Derrida, allow Christopher Elson and Garry Sherbert to develop the implications of this singular intellectual friendship. In these thinkers' efforts to reinvent secular forms of the sacred, such as the singularity of the name, and especially poetic naming, Deguy, by adopting a Derridean programme of the impossible, (...) and Derrida, by developing Deguy's ethics of naming through the word "salut," situate themselves at the forefront of contemporary debates over politics and religion alongside figures like Alain Badiou and Jean-Luc Marion, John Caputo and Martin Hagglund. (shrink)

In Life's Dominion Dworkin argues that the debate about abortion is habitually misconstrued. Substantial areas of agreement are overlooked, while areas of disagreement are, mistakenly, seen as central. If we uncover a truer picture, then hope of a certain accord may no longer seem vain. I dispute many of these claims. Dworkin argues that both sides in the debate are united in believing that life is sacred, or intrinsically valuable. I disagree. I maintain that only in a very attenuated sense (...) of intrinsic value will this be agreed upon. I consider how an account of such value might be further fleshed out, but suggest, if this is done on any plausible lines, agreement will fall away. Dworkin argues, also, that the issue of personhood, does not, contrary to widespread belief, keep the parties apart. Again I disagree. We need to distinguish the question of whether there is in fact dispute over this issue from that of whether there is, in truth, good reason for dispute. And I argue that, rightly or wrongly, the issue of personhood remains central. Dworkin suggests that the purported proximity between the two sides offers some hope of an eventual reconciliation. At least, they will agree to differ, accepting that in this area freedom of choice is paramount. I am sceptical. Even this measure of reconciliation depends upon conservatives giving up positions which, I argue, they will continue to maintain. There is a further point. Dworkin appears to be, in many ways, cautiously optimistic. I appear, in contrast, to be pessimistic. I argue, however, that only so long as we do disagree over matters of substance is there much hope that our differences might be resolved. (shrink)

Combining the fields of international trade theory, economic development, and economic growth, this text provides an advanced exposition suitable for graduate students as well as researchers at all levels. It combines mathematical rigour with an exceptional breadth of approaches, including institutions, history, and comparative economics. Existing research is exposited and evaluated, and numerous new results are included. The central themes of economic inequality, within and between nations, are discussed, as is convergence, or the reduction of inequality. Distinctive features of the (...) volume include a radical re-evaluation of the theoretical basis of the economic convergence model proposed by Barro and Sala-i-Martin, a new generalization of the standard HOS model, and a new concept, the economic environment, designed to model the effects of institutions in a more analytical and micro-founded manner is discussed. Uniquely, the real world examples included focus not only on countries participating fully in globalized trade, like China, but also those countries and regions failing to fully participate, specifically the Arab world and sub-Saharan Africa. The text concludes with a discussion of current issues in world economic governance, particularly the IMF and limitations of the Washington consensus, showing that some criticism fails to confront fundamental difficulties. (shrink)

Volume 25, Issue 3, September 2019, Page 286-289.

"This book addresses the apparent contradiction in moral condemnation of good artworks.

Deconstructing Azawad -- The plundering of Mali, past and present -- The African trace -- The Sahelian specter -- The duty of violence -- Nyama, fratricide, and reconciliation -- What is to be done? -- Zongo, Sankara, and the Burkinabe revolution.

Robert Reilly’s America on Trial presents a lengthy defense of the principles of the American Founding against recent critiques, especially focusing on those written from a Catholic perspective. His book finds a place in a larger discussion of American Catholic political thought that has been going on for more than a century. I first situate Reilly’s book within that debate, and then argue that Reilly’s account is correct on most counts. Some loose ends remain, but they can be dealt with (...) by expanding some of the points that Reilly has already made. I think, though, that other points not even raised by Reilly’s critics will require further reflection by future American Catholic political thinkers. In 2020, the sensus communis in America has ceased to be “cool and deliberate,” a desideratum for the regime mentioned in Federalist 63; we need to figure out ways to make it cool again. (shrink)

This book defends the thesis that Kant's normative ethics and his practical ethics of sex and marriage can be valuable resources for people engaged in the contemporary debate over same-sex marriage. It does so by first developing a reading of Kant's normative ethics that explains the way in which Kant's notions of human moral imperfection unsocial sociability inform his ethical thinking. The book then offers a systematic treatment of Kant's views of sex and marriage, arguing that Kant's views are more (...) defensible than some of his critics have made them out to be. Drawing on Kant's account of marriage and his conception of moral friendship, the book argues that Kant's ethics can be used to develop a defense of same-sex marriage. (shrink)

Baker, James and Reader offer new religious engagement with the public sphere via means of interdisciplinary analysis and empirical examples, developing what we call a Relational Christian Realism building upon interaction with contemporary Philosophy of Religion. This book represents an exciting contribution to philosophy and practice of religion on both sides of the Atlantic and aspires to be sufficiently interdisciplinary to also appeal to readerships engaged in the study of modern political and social trends.

Featuring essays from leading philosophical scholars, __12 Modern Philosophers__ explores the works, origins, and influences of twelve of the most important late 20th Century philosophers working in the analytic tradition. Draws on essays from well-known scholars, including Thomas Baldwin, Catherine Wilson, Adrian Moore and Lori Gruen Locates the authors and their oeuvre within the context of the discipline as a whole Considers how contemporary philosophy both draws from, and contributes to, the broader intellectual and cultural milieu.

This is both a modest and a presumptuous work. It is presumptuous because, given the vast literature on just one of its themes, it attempts to discuss not only the philosophies of both Hume and Hegel but also something of their intellectual milieu. Moreover, though the study has a delimiting perspective in the relation ship between a theory of human nature and an account of the various aspects that make up social experience, this itself is so central and protean that (...) it has necessitated a discussion of, amongst others, theories of history, language, aesthetics, law and politics. Yet it is a modest work in that, although I do think I have some fresh things to say, the study does not propose any revolutionary new reading of the material. I am not here interested in the relative validity of the theories put forward - I do not 'take sides'. Nevertheless it is part of the modest intent that recourse to Hume and Hegel in arguments pertaining to human nature will be better inform ed and more discriminating as a consequence of this study. Additionally, some distinctions herein made also shed light on some assumptions made in contem porary debates in the philosophy of social science, especially those concerning the understanding of alien belief-systems. (shrink)

This chapter contains section titled: Feeble Versions Robust Versions The Body View Who's Who? The Soul View The Reincarnation View Is There an Afterlife? Might I Live On?

In this comment, I raise a number of concerns about David Shoemaker’s adoption of the quality of will approach in his recent book, Responsibility from the Margins. I am not sure that the quality of will approach is given an adequate grounding that defends it against alternative models of moral responsibility; and it is unclear what the argument is for Shoemaker’s tripartite version of the quality of will approach. One possibility that might fit with Shoemaker’s text is that the tripartite (...) model is meant to be grounded in empirical claims about the structure of encapsulated emotions; but I argue that those empirical claims are not made out, and that regardless it is doubtful whether this is the most helpful model of the emotions to deploy in this context. In contrast, I propose that the quality of will approach is better defended in ethical terms, by reference to the vision of the value of living together as equals that is embodied in P.F. Strawson’s picture of the engaged attitude, and the emotions involved in it. (shrink)

The third volume in the Major Conservative and Libertarian Thinkers.

In this paper, I will provide a picture of the Bhopal disaster from an engineering ethics perspective. I find that the individual engineers involved in Bhopal acted ethically, for the most part, but that these actions failed to prevent the disaster for structural reasons. Nonetheless, there is no single level of analysis at which the problems that caused the Bhopal incident can be solved. Rather, a coordinated attempt must be made to change how individual engineers conceive of their work, how (...) the professional community conceives of its role in supporting ethical conduct, and how societies use regulatory and judicial systems to provide the right incentives to the organizations that engineers work for. (shrink)

Recent work in ethics and epistemology argues that physical surroundings have normative force. The ideas of 'grounding knowledge' and 'real ethics' provide an important way to understand sense of place. This paper uses this work to argue that there is a moral structure to material culture, and that the existence of this moral structure makes it necessary for us to pay attention to the epistemic import of the physical environments we create and live in. Since environments are thick with moral (...) norms, it is incumbent upon us to figure out what kinds of environments are most conducive to our shared visions of the good life. (shrink)

There are ten studies in the collection, three (1-3) previously unpublished, six either in press or already published (4-8, 10) either in French or in English ; the ninth was published in Portuguese, but now appears in French. One of the latter seven items (no.8) has evidently been revised ; otherwise only 1-3 appear to be genuinely new. 4-10 also seem by and large to retain their original formatting ; there are no cross-references – none, at any rate, that I (...) have observed – between the piece... (shrink)

Zusammenfassung Mein Aufsatz behandelt britische Reisende und Entdecker entlang der britischen Nordwest-‚frontier‘ Indiens von der napoleonischen Zeit bis zum zwanzigsten Jahrhundert. Er untersucht, wie britische Offiziere, Geographen, Archäologen und einfache Abenteurer das Motiv, in Alexanders ‚Fußstapfen‘ oder ‚Spuren‘ zu reisen, aufgegriffen haben. Die Quellengrundlage der Arbeit bilden Reiseberichte, ein literarisches Genre, das sich während der Blütezeit des britischen Empires großer Popularität erfreute. Obgleich diese Reiseberichte im,langen 19. Jahrhundert‘ von unterschiedlichen Erfahrungen und historischen Kontexten geprägt waren und sich der Charakter der (...) Reisen und Reisenden unterschied, blieb das Reisen in den ‚Fußstapfen‘ oder ‚Spuren‘ Alexanders durchgängig ein zentraler literarischer Topos. Bei aller Heterogenität der Textquellen zeigt die vorgelegte Analyse, dass die kulturelle Erinnerung an Alexander den Großen ein zentrales diskursives Instrument war, um die historische ‚Mission‘ Großbritanniens in Zentralasien zu interpretieren und eine symbolische Projektionsfläche zu bieten, die einen Austausch zwischen Vergangenheit und Gegenwart, zwischen Briten und Indigenen eröffnete. Auf dieser Grundlage arbeitet der Aufsatz die für die Antikenrezeption in Reiseberichten prägenden Modi heraus, die geographische, selbstrepräsentative, kulturelle sowie identitätsstiftende Aspekte umfasste. (shrink)

The connection between ethics and theological vision has become increasingly important for ethics as we better appreciate how the moral agent is embedded in a framework that affectively and intellectually shapes her moral reasoning. Moral reasoning is always reasoning within (that is, within a moral framework, a religious worldview, and/or a set of ideological commitments). A similar framing occurs in literature, which I refer to as its “horizon.” A literary text's horizon comprises the theological and metaphysical commitments that are implied (...) by the text and that the reader relies on to make sense of it. I suggest that there is a parallel between how moral frameworks and literary horizons operate in that both shape moral judgment. I argue that in using literature as a resource for ethics, the same contemporary currents that have led us to appreciate the embeddedness of moral reasoning should also encourage us to give more careful attention to the theological or metaphysical vision implied by a text. Such a “theo-ethical” reading of literature provides a richer understanding of particular moral goods and the interplay between those goods and ethical themes like agency, hope, and redemption. I substantiate this claim with a reading of William Blake's Jerusalem: The Emanation of the Giant Albion. (shrink)

In this paper, I examine arguments from Stephen Munzer and A. John Simmons and find that historical entitlement arguments for private property ownership are either too weak to justify poverty, as they must if they are to defend a property system wherein historical entitlement claims dominate, or they are subject to Jeremy Waldron’s “Proudhon Strategy.” I conclude that a general rights-based property system can accommodate the attractive aspects of historical entitlement arguments.