Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the (...) range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and tim.. (shrink)

"First Published in 1998, Routledge is an imprint of Taylor & Francis, an informa company.".

As highlighted by Pavarini et al., researchers in the field of bioethics have to remain critical and reflexive on the methodology and on the tools they use for their research purpose because...

Dynamic Syntax (DS: Kempson et al. 2001; Cann et al. 2005) is an action-based grammar formalism which models the process of natural language understanding as monotonic tree growth. This paper presents an introduction to the notions of incrementality and underspecification and update, drawing on the assumptions made by DS. It lays out the tools of the theoretical framework that are necessary to understand the accounts developed in the other contributions to the Special Issue. It also represents an up-to-date account of (...) the framework, combining the developments that have previously remained distributed in a diverse body of literature. (shrink)

One major insight derived from the moral twin earth debate is that evaluative and descriptive terms possess different levels of semantic stability, in that the meanings of the former but not the latter tend to remain constant over significant counterfactual variance in patterns of application. At the same time, it is common in metanormative debate to divide evaluative terms into those that are thin and those that are thick. In this paper, I combine debates about semantic stability and the distinction (...) between the thin and the thick by presenting a new seamless inferentialist account of thin and thick evaluative terms which, despite subsuming them under the same metasemantic analysis, can nevertheless account for their varying levels of semantic stability. According to this position of ‘seamless metaconceptualism’, thin and thick evaluative terms do not belong to different categories, but are both understood as metaconceptual devices which do not differ in kind, but in scope. By providing the same analysis for both thin and thick terms, seamless metaconceptualism not only entails that the latter cannot shoulder the philosophical work that some have attributed to them, but also removes much of their surrounding intrigue. (shrink)

This paper offers an account of the property Feuerbach and Marx called “species-being,” the human being’s distinctive tendency to identify herself as a member of her species, and to think of the species as a “we.” It links the notion to Kant’s theory of rights, arguing that every claim of right commits the maker of that claim to something like world government, and therefore to the conception of humanity as a collective agent. It also links species-being to the concept of (...) practical identity, arguing that the conceptions under which we find our lives and actions valuable are ones according to which we make a positive contribution to the life of the species. It then argues that the resulting conception of humanity, together with certain considerations about the nature of the good, provides grounds for challenging the familiar claim that death is generally worse for human beings than for animals. On the other hand, because of species-being, the extinction of our species is a much worse prospect for human beings than for the other animals. (shrink)

Sound moves us. Nowhere is this more apparent than in our responses to genuine emotional vocalizations, be they heartfelt distress cries or raucous laughter. Here, we present perceptual ratings and a description of a freely available, large database of natural affective vocal sounds from human infants, adults and domestic animals, the Oxford Vocal (OxVoc) Sounds database. This database consists of 173 non-verbal sounds expressing a range of happy, sad, and neutral emotional states. Ratings are presented for the sounds on a (...) range of dimensions from a number of independent participant samples. Perceptions related to valence, including distress, vocalizer mood, and listener mood are presented in Study 1. Perceptions of the arousal of the sound, listener motivation to respond and valence (positive, negative) are presented in Study 2. Perceptions of the emotional content of the stimuli in both Study 1 and 2 were consistent with the predefined categories (e.g., laugh stimuli perceived as positive). While the adult vocalizations received more extreme valence ratings, rated motivation to respond to the sounds was highest for the infant sounds. The major advantages of this database are the inclusion of vocalizations from naturalistic situations, which represent genuine expressions of emotion, and the inclusion of vocalizations from animals and infants, providing comparison stimuli for use in cross-species and developmental studies. The associated website provides a detailed description of the physical properties of each sound stimulus along with cross-category descriptions. (shrink)

This article presents the results of an evaluative research on the impacts of collaborative research in the evolution of the practices of researchers and associated teachers. It was a question of understanding how the collaborative approach was useful and relevant to the participants, how it enabled them to better take ownership of their role as an associate teacher, and how to transform their practices.

Vulnerability in research is often understood as a diminished ability to protect one's own interests, manifested by a compromised capacity to give informed or voluntary consent. Certain groups of people are thought to be more vulnerable than others and therefore are at risk of being exploited or mistreated in research. Accordingly, the federal regulations call for additional safeguards to protect vulnerable groups.There remains some ambiguity and contradiction, however, regarding what groups are vulnerable in research and why,3 since the available codes (...) of research ethics and regulations describe many groups as vulnerable. When so many groups are considered vulnerable, but no specification is offered as to how they are vulnerable or what particular protections are appropriate, the possibility of meaningful safeguards is diminished. In addition, current concepts of vulnerability are usually applied to whole groups of people, without distinguishing between individuals in a group who might truly have a compromised capacity to protect their own interests from those who do not. (shrink)

abstractBackground: Evidence shows both a tendency for research participants to conflate research and clinical care and a limited public understanding of research. Conflation of research and care by participants is often referred to as the therapeutic misconception. Despite this evidence, few studies have explicitly asked participants, and especially minors, to explain what they think research is and how they think it differs from regular medical care. Methods: As part of a longer semistructured interview evaluating assent and parental permission for research, (...) adolescent research participants (n = 177), including adolescents with illnesses and healthy volunteers, and their parents (n = 177) were asked to describe medical research in their own words and say whether and how they thought being in medical research was different from seeing a regular doctor. Qualitative responses were coded and themes were identified through an iterative process. Results: When asked to describe medical research, the majority described research in terms of its goals of helping to advance science, develop treatments and medicines, and help others; fewer described research as having the goal of helping particular research participants, and fewer still in terms of the methods used in research. The majority of teen and parent respondents said being in research is different than seeing a regular doctor and explained this by describing different goals, different or more procedures, differences in the engagement of the doctors/researchers, and differences in logistics. Conclusions: Adolescents participating in clinical research and their parents generally describe medical research in terms of its goals of advancing science and finding new medicines and treatments, sometimes in combination with helping the enrolled individuals. The majority perceive a difference between research and regular medical care and described these differences in various ways. Further exploration is warranted about how such perceived differences matter to participants and how this understanding could be used to enhance informed consent and the overall research experience. (shrink)

The personal writings of First World War nurses and VADs (volunteers) provide the historian with a range of insights into the war and women's nursing roles within it. This paper offers a number of methodological perspectives on these writings. In particular, it emphasises two elements of engagement with texts that can act as important influences on subsequent historical writings: authorial intention and scholarly interpretation. In considering the interplay of these two elements, the paper emphasises the motivations both of those who (...) produced primary sources and of those who later used them to ‘serve’ particular historical interpretations. The paper examines letters, diaries and semi‐fictional writings, considering the influences of gender, class and professional background on the ways in which their authors wrote. It then briefly considers the uses to which historians have put these original writings. The paper offers insights into the ways in which complex personal writings can be interpreted and concludes that the writings of First World War nurses and volunteers offer a rich and varied set of perspectives on both the war itself and the nature of wartime nursing work. (shrink)

This paper starts off from what seems to be a difficulty of ethics in African Business today. For several years now Transparency International has placed some African countries high on its list of most corrupt countries of the world. The conclusion one draws from this assessment is that either African culture has no regard or concern for ethics, or that there has been a gradual loss of the concept of the ethical and the moral in contemporary African society. Equally problematic (...) is the teaching and promotion of Business ethics in organizations. Western philosophical theories and systems alone have not succeeded in providing access to ethical life of people in modern Africa. This paper is an attempt to inject an orientation that takes into account African manners and customs, their religious convictions and their understanding of the world as a whole, in the teaching of Business Ethics. East and Central Africa have been selected due to their common lingua franca, Kiswahili, and the fact that the author has more teaching experience within that region. (shrink)

What would a person look like if she were to possess a virtue like compassion or courage? This is the question that will come to mind when contemplating the hau.

This essay examines the reconfiguration of the racial and sexual contracts underpinning democratic theory and practice in the transition to independence in India. Drawing upon the work of Carole Pateman and Charles Mills, Keating argues that the racialized fraternal democratic order that they describe was importantly challenged by nationalist and feminist struggles against colonialism in India, but was reshaped into what she calls a postcolonial sexual contract by the framers of the Indian Constitution.

Cette introduction à une collection d'articles sur la normativité propose d'adopter les divisions trouvées habituellement en éthique pour aborder la normativité. Ainsi, il semble utile de diviser les questions en cinq groupes: l'ontologie normative, la sémantique normative, l'épistémologie normative, la psychologie normative, et finalement, les questions normatives substantielles.

In der gegenwärtigen Forschung wird die Hervorbringung von Kunst und Wissenschaften vor allem unter dem Gesichtspunkt der Abhängigkeit thematisiert, in der sie von ihren Auftrag- bzw. Geldgebern steht. Das Augenmerk gilt den partikularen Interessen, die politisch Mächtige verfolgen, wenn sie Künstler oder Gelehrte alimentieren: Repräsentation, Legitimierung von Herrschaftsansprüchen, Distinktion mit Hilfe von kulturellem Kapital lauten die gängigen Stichworte. Demgegenüber wird in diesem Band gezeigt, dass umgekehrt auch die Mächtigen von den Kulturschaffenden abhängig sind. Denn Wissenschaft und Kunst können -- statt (...) als Propaganda und schöner Schein -- auch als spezifische Formen universalistischer Rationalität aufgefasst werden. So begriffen, sind sie es, die in ihren Ausdrucksformen und Diskursen über die Vernünftigkeit einer Herrschaft verhandeln. Indem sie politische, wirtschaftliche und soziale Geltungsansprüche argumentativ bzw. ästhetisch durchdeklinieren, stellen sie diese zugleich auf den Prüfstand und sie geben als Experten für die Erzeugung von Neuem den Herrschern unbekannte, fremdartige Ideen. (shrink)

The integral role of royal women in political systems structured by diplomatic marriage is revealed in a series of legal verdicts from a case that involved the rulers of Late Bronze Age Ugarit, Amurru, and Ḫatti. These verdicts adjudicate the divorce, loss of political status, and execution of a royal woman who was the wife of the king of Ugarit, the daughter and sister of two successive kings of Amurru, and the granddaughter and niece of two successive Hittite Great Kings. (...) The undoing of her multivalent political status destabilized the regional and imperial system in which she was enmeshed. Protracted negotiations were required to restore equilibrium to the system. Examination of the rhetorical and legal strategies through which these negotiations took place reveals the extent to which the relative power of royal men depended on their relationships to royal women. (shrink)

The interlocutors of Plato’s Cratylus agree that “it is far better to learn and to inquire from the things themselves than from their names”. Although surprisingly little attention has been paid to these remarks, at least some commentators view Plato as articulating a preference for direct, nonlinguistic cognitive access to the objects of inquiry. Another commentator takes Plato simply to recommend first-hand, yet linguistic, experience in addition to instruction from experts. This paper defends, in contrast to both interpretations, the view (...) that inquiry without names is dialectical, linguistic inquiry into metaphysical first principles. As such, inquiry without names is prior to inquiry from or through names. Inquiry without names is a form of transcendental metaphysics. (shrink)

The Cratylus contains Plato's most extensive study of the relation of language to reality and to the pursuit of wisdom. Yet the dialogue has remained relatively neglected in efforts to understand Plato's deepest metaphysical and epistemological commitments. The blame for such neglect lies largely in the dialogue's extensive, difficult, even mysterious etymological section. Recent attempts to make sense of the bulk of the Cratylus are shedding much welcome light on the important roles that the etymological analyses play in the dialogue (...) and in Plato's philosophy more generally. The article outlines three strategies of interpretation before concluding with the author's own proposal. (shrink)

Nicht selten wird zum Beispiel in Diskussionen um „Political Correctness“ oder „Cancel Culture“ Kritik an bestimmten Positionen geübt und im Namen der Meinungsfreiheit zugleich Kritik an der eigenen Meinung zurückgewiesen. Offenbar besteht Klärungsbedarf in Bezug darauf, ob und, wenn ja, wann Kritik ebenso wie ihre Zurückweisung berechtigt sind. Hierzu gilt es insbesondere den Zusammenhang eingehender zu betrachten zwischen dem universellen Recht auf Redefreiheit, dessen gesetzlicher Kodifizierung und den ethischen Anforderungen, denen Redebeiträge und deren Kritik unterstehen. In sieben Beiträgen wird aus (...) unterschiedlichen Blickwinkeln das Thema des Schwerpunkts „Redefreiheit und Kritik: Müssen wir alles tolerieren, was andere sagen?“ beleuchtet. Dabei soll auch die öffentliche und nicht nur die akademische Debatte über das Recht auf Rede- bzw. Meinungsfreiheit sowie die normativen Grenzen von Kritik bereichert werden. (shrink)

This paper reviews the main pricing policies in Latin American countries, discussing their shortcomings. It also gives an overview of the most common pricing and reimbursement policies in Europe and describes in detail three well-established approaches — international price referencing, value-based pricing, including setting up of health technology assessment, and generic and biosimilar policies — building on country examples.

One factor that impedes medical students from speaking up about ethical situations is the lack of sufficient knowledge and skills in conflict resolution. This may also affect students’ decision and timing to intervene. This article will provide practical ways to effectively and efficiently address the medical student’s ethical case presented in August A. Culbert et al.’s “Navigating Informed Consent and Patient Safety in Surgery: Lessons for Medical Students and Junior Trainees.”.

Quand Colbert fonda l’Académie des sciences dans le but de dynamiser l’industrie, aucun chimiste de l’Académie n’était encore susceptible de rationaliser l’art très empirique de la teinture. Au XVIIe siècle, la teinture n’était pas un sujet traité lors des séances de l’Académie, en revanche l’intérêt des académiciens pour cet art chimique a pris de l’ampleur dans les années 1750 sous l’impulsion de Pierre-Joseph Macquer et du Bureau du Commerce. Dans cet article, la présentation de l’art de la teinture à l’Académie (...) des sciences au XVIIIe siècle est centrée principalement sur les premiers travaux académiques sur la teinture, sur les mémoires de Macquer, ainsi que sur les prix et les publications sur la teinture proposés par l’Académie.Au cours du XVIIIe siècle, la teinture abandonnera le monde des artisans teinturiers pour intéresser le monde savant et les académiciens. La teinture acquerra ses lettres de noblesse, sortant des ateliers pour entrer à l’Académie avant de s’enseigner comme la chimie. (shrink)

Le syntagme « philosophie de la danse » fait surgir une tension aporétique : soit le philosophe esthéticien évince le _danser_ pour réduire la danse à la réception de son spectacle, soit il assimile la danse à une pensée ou un langage – ce qui est bien mal connaître l’absentement du concept en danse, supplanté par autant d’intuitions locomotrices. À titre alternatif, je soutiendrai que la pratique de la danse est révélatrice des dimensions non conceptuelles de la vérité, qualifiables d’ (...) « intuitions claires et évidentes » et posées comme condition même de toute connaissance par Descartes ; ou « vérités du cœur » de même valeur que les connaissances rationnelles selon Pascal. (shrink)