This work has been done with the purpose of determining the influence of neuromarketing in the levels of consumer purchase of the Paseo Shopping Ambato Mall, neuromarketing has applied neuroscience techniques focused on marketing in order to study different brain areas that are activated in the consumer when choosing a product as well as it is based on the consumer, since its objective is the identification of the impact generated by a product or brand, the understanding of the consumer when (...) making a purchase or acquisition and the identification and satisfaction of customer needs, along with the characteristics measured by neuromarketing, which are attention, emotion and memory. The objective of the research is focused on analyzing the influence of neuromarketing in the purchase process, relating the importance that requires broadening knowledge in the understanding of the levels and stimuli that are emitted by the brands of the different products that are offered in a shopping center. The present investigation determines the neuromarketing actions to better understand the expressions and non-verbal reactions that consumers develop, associated with the advertising practices that are used in the Paseo Shopping Ambato Shopping Center; where commercial sales transactions become the result of the emotions shown by consumers towards a certain product or service. The analysis is obtained by applying a conceptual investigation on the fundamentals of neuromarketing in the purchase decision process and its influence towards a specific decision. Neuromarketing has positively influenced the purchase of a certain product by the consumer. (shrink)

: When may a physician legitimately offer enrollment in a randomized clinical trial (RCT) to her patient? Two answers to this question have had a profound impact on the research ethics literature. Equipoise, as originated by Charles Fried, which we term Fried's equipoise (FE), stipulates that a physician may offer trial enrollment to her patient only when the physician is genuinely uncertain as to the preferred treatment. Clinical equipoise (CE), originated by Benjamin Freedman, requires that there exist a state (...) of honest, professional disagreement in the community of expert practitioners as to the preferred treatment. FE and CE are widely understood as competing concepts. We argue that FE and CE offer separable and, in themselves, incomplete justifications for the conduct of clinical trials. FE articulates conditions under which the fiduciary duties of physician to patient may be upheld in the conduct of research. CE sets out a standard for the social approval of research by institutional review boards. Viewed in this way, FE and CE are not necessarily competing notions, but rather address complementary moral concerns. (shrink)

BackgroundIn December 2014, China announced that only voluntarily donated organs from citizens would be used for transplantation after January 1, 2015. Many medical professionals worldwide believe that China has stopped using organs from death-row prisoners.DiscussionIn the present article, we briefly review the historical development of organ procurement from death-row prisoners in China and comprehensively analyze the social-political background and the legal basis of the announcement. The announcement was not accompanied by any change in organ sourcing legislations or regulations. As a (...) fact, the use of prisoner organs remains legal in China. Even after January 2015, key Chinese transplant officials have repeatedly stated that death-row prisoners have the same right as regular citizens to “voluntarily donate” organs. This perpetuates an unethical organ procurement system in ongoing violation of international standards.ConclusionsOrgan sourcing from death-row prisoners has not stopped in China. The 2014 announcement refers to the intention to stop the use of organs illegally harvested without the consent of the prisoners. Prisoner organs procured with “consent” are now simply labelled as “voluntarily donations from citizens”. The semantic switch may whitewash sourcing from both death-row prisoners and prisoners of conscience. China can gain credibility only by enacting new legislation prohibiting use of prisoner organs and by making its organ sourcing system open to international inspections. Until international ethical standards are transparently met, sanctions should remain. (shrink)

Franklin G. Miller and colleagues have stimulated renewed interest in research ethics through their work criticizing clinical equipoise. Over three years and some twenty articles, they have also worked to articulate a positive alternative view on norms governing the conduct of clinical research. Shared presuppositions underlie the positive and critical dimensions of Miller and colleagues' work. However, recognizing that constructive contributions to the field ought to enjoy priority, we presently scrutinize the constructive dimension of their work. We argue that it (...) is wanting in several respects. (shrink)

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and are (...) better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

: In response to the preceding commentary by Jerry Menikoff in this issue of the Journal , the authors argue that Fried's central concern is not that randomized clinical trials (RCTs) are conducted without consent, but rather that various aspects of the design and conduct of RCTs are in tension with physicians' duties of personal care to their patients. Although Fried does argue that the existence of equipoise cannot justify failure to obtain consent from research subjects, informed consent by itself (...) does not supplant ill subjects' rights to personalized judgment and care embodied in Fried's equipoise. (shrink)

The question "When are research risks reasonable in relation to anticipated benefits?" is at the heart of disputes in the ethics of clinical research. Institutional review boards are often criticized for inconsistent decision-making, a problem that is compounded by a number of contemporary controversies, including the ethics of research involving placebo controls, developing countries, incapable adults and emergency rooms. If this pressing ethical question is to be addressed in a principled way, then a systematic approach to the ethics of risk (...) in research is required. Component analysis provides such a systematic approach. (shrink)

When may a physician enroll a patient in clinical research? An adequate answer to this question requires clarification of trust-based obligations of the state and the physician-researcher respectively to the patient-subject. The state relies on the voluntarism of patient-subjects to advance the public interest in science. Accordingly, it is obligated to protect the agent-neutral interests of patient-subjects through promulgating standards that secure these interests. Component analysis is the only comprehensive and systematic specification of regulatory standards for benefit-harm evaluation by research (...) ethics committees (RECs). Clinical equipoise, a standard in component analysis, ensures the treatment arms of a randomised control trial are consistent with competent medical care. It thus serves to protect agent-neutral welfare interests of the patient-subject. But REC review occurs prior to enrolment, highlighting the independent responsibility of the physician-researcher to protect the agent-relative welfare interests of the patient-subject. In a novel interpretation of the duty of care, we argue for a “clinical judgment principle” which requires the physician-researcher to exercise judgment in the interests of the patient-subject taking into account evidence on treatments and the patient-subject‘s circumstances. (shrink)

The new National Institutes of Health (NIH) Policy on the Use of a Single Institutional Review Board (sIRB) for Multi-Site Research was adopted primarily to simplify and speed the review of complex multisite clinical trials. However, speeding review requires overcoming a number of obstacles. Perhaps the most substantial obstacle is the time and effort needed to develop reliance agreements among the participating sites. We conducted 102 semistructured interviews with sIRB personnel, including directors, chairs, reviewers, and staff, from 20 IRBs that (...) acted as sIRBs for multisite research, including 6 commercial/independent sIRBs, and 10 university-based academic and 4 federal sIRBs. Almost without exception, the interviewees agreed that reliance agreements were complex, difficult to develop, and time-consuming. A major problem for relying sites was that different agreements specified different responsibilities for the relying sites. Attitudes differed about whether these problems will be resolved as IRB staff and managers become more experienced with sIRBs. However it is clear that the process of developing reliance agreements must be simplified. Federal assistance in standardizing at least some sections of reliance agreements might reduce the difficulties involved. (shrink)

: Responding to the paper by Miller and Joffe, we review the development of the concept of therapeutic misconception (TM). Our concerns about TM's impact on informed consent do not derive from the belief that research subjects have poorer outcomes than persons receiving ordinary clinical care. Rather, we believe that subjects with TM cannot give an adequate informed consent to research participation, which harms their dignitary interests and their abilities to make meaningful decisions. Ironically, Miller and Joffe's approach ends up (...) largely embracing the very position that they inaccurately attribute to us: the belief that, with some exceptions, it is only the prospect of poorer outcomes that should motivate efforts to dispel TM. In the absence of empirical studies on the steps required to dispel TM and the impact of such procedures on subject recruitment, it is premature to surrender to the belief that TM must be widely tolerated in clinical research. (shrink)

Physicist David Bohm and biochemist Ilya Prigogine began a dialogue that implied a deep, structuring, primordial harmony within life. In classical Chinese this harmony is referred to as Li, which also designates the elegant, natural pattern found in jade. This article emphasizes the ways that perception of primordial harmony gives way to a vision of possibility and to the creative intelligence and action necessary for meeting the challenges we face. Insights from Bohm, Prigogine, and others on releasing outmoded thinking and (...) actions are integrated with contemplative traditions, Eastern and Western philosophy, and pragmatic strategy making. (shrink)

Plato's account of the famous trial of Socrates in 399 b.c., appeals to historians, philosophers, political scientists, and classicists. It is also essential reading for students of ancient Greek. Paul Allen Miller and Charles Platter provide running commentary, glosses of unfamiliar words, introductions that address historical and philosophical issues, and thought-provoking essays on each chapter.

Charles Stankievech presents his fieldwork—research into the technologies and architectures of the twentieth century global north—as uncanny self-portraits of the societies that built those structures. So presented, these peripheral spaces and exceptional technologies can be understood as generating the cores of the societies that commissioned those outlying structures and technologies.

This substantial anthology is a comprehensive, authoritative collection of the classical and contemporary readings in the philosophy of religion, providing a survey and analysis of the key issues, figures and concepts. Comprises the most comprehensive and authoritative collection of the classical and contemporary readings in the philosophy of religion. Provides a survey and analysis of the key issues, figures and concepts. Examines religious identity, theism and divine attributes, explanations of religion, and theistic arguments. Includes readings concerned with nontheistic religions, evils (...) and goods, religious values, personal identity, and death. (shrink)

Bioethics is currently witnessing unprecedented debate over the moral and legal norms governing the conduct of clinical research. At the center of this debate is the duty of care in clinical research, and its most widely accepted specification, clinical equipoise. In recent work, we have argued that equipoise and cognate concepts central to the ethics of clinical research have been left unnecessarily vulnerable to criticism. We have suggested that the vulnerability lies in the conspicuous absence of an articulated foundation in (...) moral and legal theory of the physician-researcher's duty of care to the patient-subject. We have repeatedly suggested that the requisite foundation is in the ethics of trust and the law of fiduciaries.Curiously, despite the absence of a published thorough exposition of our position, some have preemptively criticized our suggestion that the relationship between physician-researcher and patient-subject is fiduciary. Others have offered their own accounts of the implications of fiduciary law for the relationship. (shrink)

This volume exposes naturalism’s unnaturalness and defends theism’s naturalness and greater explanatory power to account for wide-ranging phenomena in the world and human experience. A broadening of naturalism to accommodate these features means borrowing heavily from—and thus more closely resembling—a theistic worldview.

Paul Merkley draws on the published literature of the World Council of Churches, the Middle East Council of Churches, the Roman Catholic Church, and other Christian organizations that have an interest in the question of Israel's past, present, and future, and on interviews with numerous key figures within the government of Israel, spokesmen for the Palestine Authority, and leaders of all the major pro and anti-Zionist Christian organizations to demonstrate that Christian attitudes towards Israel remain remarkably polarized. To most (...) evangelical and fundamentalist Christians, loyalty to Israel is a kind of second patriotism, nurtured by the conviction that Israel's restoration is a part of God's plan for history. However mainstream Protestantism champions "Palestinian nationalism" and, drawing on the rhetoric of the Middle East Council of Churches, does not hesitate to portray Israel as an Aoppressor." Merkley concludes that Christian attitudes towards Israel reflect fundamental theological attitudes that must be studied against the long historical background of Christian attitudes towards Judaism and Islam. (shrink)

Over 90% of the organs transplanted in China before 2010 were procured from prisoners. Although Chinese officials announced in December 2014 that the country would completely cease using organs harvested from prisoners, no regulatory adjustments or changes in China’s organ donation laws followed. As a result, the use of prisoner organs remains legal in China if consent is obtained. We have collected and analysed available evidence on human rights violations in the organ procurement practice in China. We demonstrate that the (...) practice not only violates international ethics standards, it is also associated with a large scale neglect of fundamental human rights. This includes organ procurement without consent from prisoners or their families as well as procurement of organs from incompletely executed, still-living prisoners. The human rights critique of these practices will also address the specific situatedness of prisoners, often conditioned and traumatized by a cascade of human rights abuses in judicial structures. To end the unethical practice and the abuse associated with it, we suggest to inextricably bind the use of human organs procured in the Chinese transplant system to enacting Chinese legislation prohibiting the use of organs from executed prisoners and making explicit rules for law enforcement. Other than that, the international community must cease to abet the continuation of the present system by demanding an authoritative ban on the use of organs from executed Chinese prisoners. (shrink)

As a 2006 Institute of Medicine report highlights, surprisingly little empirical attention has been paid to how prisoners arrive at decisions to participate in modern research. With our study, we aimed to fill this gap by identifying a more comprehensive range of factors as reported by prisoners themselves during semistructured interviews. Our participants described a diverse range of motives, both favoring and opposing their eventual decision to join. Many are well-recognized considerations among nonincarcerated clinical research participants, including a desire for (...) various forms of personal benefit, altruism, and concern about study risks and inconveniences. However, a number of influences seem unique to prisoners. Participants did not report that they were not coerced into enrolling, and they have even been under pressure not to enroll. However, many sought to enroll in order to obtain access to better health care, raising a concern about whether they were unfairly exploited. (shrink)

It is now well documented that biology needs morphometrics. Morphometrics can provide useful and often unexpected information about development and growth, functional—especially mechanical—adaptation, and evolutionary difference and relationship. Such studies often apply coordinate data from anatomical landmarks. Recently semi-landmarks and sliding landmarks increase information content, especially of apparently featureless regions . Yet, how we landmark our materials limits the results we get and the questions we ask. Here we show different landmarking schemes leading to different equivalences between specimens and different (...) results. Geometric morphometric methods often treat landmarks as points on rubber sheets. Distortions of the sheets are often visualized by techniques like thin plate splines showing changes or differences as stretches or contractions. The statistics of morphometrics can handle these. Further consideration of anatomical landmarks, however, implies that real biologies are sometimes more complex. Sometimes two-dimensional rubber sheets of anatomies contain cusps or holes representing appearances or disappearances of structures. In three dimensions, equivalent rubber blocks may show not only appearances or disappearances but also reversals of positions of structures. Such phenomena are generally ignored in landmarks and analyses. We show that in some cases morphometrics can take account of such matters. But we also suggest that sometimes these modifications from elastic analogues are so complex that new methods may be required for our morphometric packages. It is in this sense that improvement of morphometrics needs deeper understanding of biology. (shrink)

An excellent introduction to mathematical logic, this book provides readers with a sound knowledge of the most important approaches to the subject, stressing the use of logical methods in attacking nontrivial problems. It covers the logic of classes, of propositions, of propositional functions, and the general syntax of language, with a brief introduction that also illustrates applications to so-called undecidability and incompleteness theorems. Other topics include the simple proof of the completeness of the theory of combinations, Church's theorem on the (...) recursive unsolvability of the decision problem for the restricted function calculus, and the demonstrable properties of a formal system as a criterion for its acceptability. 1950 ed. (shrink)