In the present paper we formulate the hypothesis that brain glycogen is a critical determinant in the modulation of carbohydrate supply at the cellular level. Specifically, we propose that mobilization of astrocytic glycogen after an increase in AMP levels during enhanced neuronal activity controls the concentration of glucose phosphates in astrocytes. This would result in modulation of glucose phosphorylation by hexokinase and upstream cell glucose uptake. This mechanism would favor glucose channeling to activated neurons, supplementing the already rich neuron‐astrocyte metabolic (...) and functional partnership with important implications for the energy compounds used to sustain neuronal activity. The hypothesis is based on recent modeling evidence suggesting that rapid glycogen breakdown can profoundly alter the short‐term kinetics of glucose delivery to neurons and astrocytes. It is also based on review of the literature relevant to glycogen metabolism during physiological brain activity, with an emphasis on the metabolic pathways identifying both the origin and the fate of this glucose reserve. (shrink)

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

My first aim in this paper is to use time diagrams in the style of Brentano to analyze constructions in Brouwer's separable mathematics more precisely. I argue that constructions must involve not only pairing and projecting as basic operations guaranteed by the intuition of twoity, as sometimes assumed in the literature, but also a recalling operation. My second aim is to argue that Brouwer's views on the intuition of twoity and arithmetic lead to an ontological explosion. Redeveloping the constructions of (...) natural numbers and systems sketched in an appendix to Brouwer's Cambridge lectures, I observe that the only plausible way he can make some elementary arithmetic in his separable mathematics is by allowing for the same canonical number to be determined by multiple separable entities, resulting in an overabundant mathematical ontology. (shrink)

It is a well-worn platitude that knowledge excludes luck. According to anti-luck virtue epistemology, making good on the anti-luck platitude requires an explicit anti-luck condition along the lines of safety: S knows that p only if S’s true belief that p could not have easily been mistaken. This paper offers an independent, virtue epistemological argument against the claim that safety is a necessary condition on knowledge, one that adequately captures the anti-luck platitude. The argument proceeds by way of analogy. I (...) focus on two paradigmatic kinds of normative achievements that also exclude luck: (i) – having a doxastically justified belief, and (ii) – performing a morally worthy action. I then show that while (i) and (ii) exclude luck, they are nevertheless susceptible to what I call ‘modal luck’. I then move on to show that knowledge, or at least some instance of knowledge, is a normative achievement, which I claim provides strong reasons to expect that knowledge is also susceptible to modal luck. Since safety entails that knowledge is incompatible with modal luck, the argument provides strong reasons to reject safety as a necessary condition on knowledge. (shrink)

The topic of liberty in Foucault becomes controversial when related to the objections, predicted by the author, for the subjects to be located outside the power networks. However, Foucault also points out potential for resistance and a notion of freedom involved by historical circumstances, which suggests original normative questions. In order to analyze the tension between domination and freedom in his work, and what is normatively reflected, two main directions are noted: the idea of freedom as something inherent in power (...) relations and as the foundation of the critical exercise of knowledge. It is argued that Foucault`s estimation of dimensions of freedom generates singular implications of evaluation of social conditions based on a normative temperance. (shrink)

It is commonly assumed that blameworthiness is epistemically constrained. If one lacks sufficient epistemic access to the fact that some action harms another, then one cannot be blamed for harming. Acceptance of an epistemic condition for blameworthiness can give rise to a worry, however: could agents ever successfully evade blameworthiness by deliberately stunting their epistemic position? I discuss a particularly worrisome version of such epistemic shirking, in which agents pre-emptively seek to avoid access to potentially morally relevant facts. As Roy (...) Sorensen and Jan Willem Wieland have argued, we seem to be faced with a potentially troubling regress when trying to explain what goes wrong in such situations. I argue that the solution to this so-called Shirker Problem is not to be found in complicated and demanding anti-shirking-principles with universal scope and potentially self-reflexive content. Instead, careful consideration of the necessary motivational make-up of genuine shirkers reveals their ignorance to lack the necessary depth to be exculpatory. Since shirkers by definition react to the possibility of the revelation of morally relevant facts with acts of epistemic self-limitation, they necessarily prove guilty of a form of culpable moral recklessness. Epistemic shirking thus does not pose a worrisome problem for ethical theory. (shrink)

Using a metacontrast masking paradigm, prior studies have shown that a target’s color information and form information, can be processed without awareness and that unconscious color processing occurs at early, wavelength-dependent levels in the cortical information processing hierarchy. Here we used a combination of paracontrast and metacontrast masking techniques to explore unconscious color and form priming effects produced by blue, green, and neutral stimuli. We found that color priming in normal observers is significantly reduced when an additional paracontrast mask precedes (...) the target at optimal masking SOAs. However, no reduction of form-priming effects was obtained at similar optimal paracontrast SOAs. We conclude that unconscious color priming depends on an early, wavelength- or stimulus-dependent response of color neurons located at early cortical levels whereas unconscious form priming occurs at later levels. (shrink)

We examined the updating of decisions made during visuo-motor processing when two sequentially presented stimuli, Prime1 and Prime2, primed discriminative responses to a following probe. In Experiment 1, the visibility of the two primes was suppressed or left intact by varying the stimulus onset asynchrony of the stimuli immediately following them. In Experiment 2, the visibility of Prime2 was suppressed or left intact by varying its spatial separation from the following probe. We found that Prime2 dominated the effects of Prime1; (...) that Prime2’s updating was stronger when the Prime2–probe SOA was 200 as compared to 53 ms; and that Prime2’s updating was weaker when the Prime2–probe spatial separation was 58 as compared to 0 minarc. We conclude that these effects are due to an interaction of spatial attention and the state of processing of Prime2. (shrink)

The economic crisis happening across the world over the last few years describes a range of interdependencies and interactions,and has highlighted the fundamentalf laws of neoclassical economic theory: its unedifying focus on prediction and, above all, its inability to explain how the economy really works. As such, it is increasingly recognised that economic phenomena cannot be exclusively investigated as being derived from deterministic, predictable and mechanistic dynamics. Instead, a new approach is required by which history-dependence, organic and ever-evolving processes are (...) also accounted for. As this view implies new challenges and opportunities for policy, we will focus our attention on innovative components of Complexity Theory for the study of economics and the evaluation of public policies. (shrink)

We show how to interpret weak Kőnig's lemma in some recently defined theories of nonstandard arithmetic in all finite types. Two types of interpretations are described, with very different verifications. The celebrated conservation result of Friedman's about weak Kőnig's lemma can be proved using these interpretations. We also address some issues concerning the collecting of witnesses in herbrandized functional interpretations.

The constructive mathematics developed by Bishop in Foundations of Constructive Analysis succeeded in gaining the attention of mathematicians, but discussions of its underlying philosophy are still rare in the literature. Commentators seem to conclude, from Bishop’s rejection of choice sequences and his severe criticism of Brouwerian intuitionism, that he is not an intuitionist–broadly understood as someone who maintains that mathematics is a mental creation, mathematics is meaningful and eludes formalization, mathematical objects are mind-dependent constructions given in intuition, and mathematical truths (...) are experienceable. This paper develops and defends an intuitionistic interpretation of Bishop’s philosophical views. (shrink)

In this paper we want to re-examine the traditional belief that phenomenological sociology owes its pedigree primarily to Alfred Schütz. More specifically, we will try to show that Max Scheler is equally worthy of the title of founder of phenomenological sociology. Our argument has three interlocking themes. First of all, we will recognize, like many others before us, the undoubtedly essential contribution made by Schütz, who is generally viewed as the father of phenomenological sociology. Our second step, however, will be (...) to return to the foundations of this approach and to show that it throws up certain difficulties. As is widely known, Schütz’s project is nothing less than to apply the Husserlian transcendental to the empirical. But, we will show that because Schütz remains caught in a king of egologic sociology, reducing intersubjectivity—and the social—to a face-to-face relationship, he fails to give to phenomenology a real sociological dimension. Nevertheless this does not mean that phenomenology does not have a powerful sociological dimension. By exploring concepts insufficiently explored by Schütz in a third step, such as Husserl’s notion of intentionality and its equivalent in Max Scheler’s thought (the frame of mind), we will explore the empirical potential of phenomenology. Scheler, considering a social environment independent (and even constitutive) of the subject, gives the final form to a phenomenological sociology, a sociology which gives us even the mean to think a sympathetic relationship with the natural world, critical of capitalism and prefiguring ecology. (shrink)

Economics and psychology are both sciences of human behaviour. This paper gives a survey of their interaction. First, the changing relationship between the two sciences is discussed: while economics was once imperialistic, it has become a science inspired by psychological insights. In order to illustrate this, recent developments and evidence for three major areas are presented: bounded rationality, non-selfish behaviour, and the economics of happiness.

Human beings under some conditions tend to systematically overestimate their possibilities, under others to underestimate what is possible for them. This behaviour can be explained by differentiating between an ipsative possibility set (which includes what individuals consider relevant for themselves) and on objective one. These two possibility sets do not necessarily coincide. The difference may firstly be due to psychologicol processes as well as factors such as tradition and ideology. The difference may secondly be strategically designed by the individuals themselves (...) knowing that they otherwise reach less utility. The approach stresses that it is essential to determine the possibility sets within which individuals rationally decide between alternatives. (shrink)

During 2018, as part of a research project funded by the Deviant Practice Grant, artist Bruno Moreschi and digital media researcher Gabriel Pereira worked with the Van Abbemuseum collection (Eindhoven, NL), reading their artworks through commercial image-recognition (computer vision) artificial intelligences from leading tech companies. The main takeaways were: somewhat as expected, AI is constructed through a capitalist and product-focused reading of the world (values that are embedded in this sociotechnical system); and that this process of using AI is (...) an innovative way for doing institutional critique, as AI offers an untrained eye that reveals the inner workings of the art system through its glitches. This paper aims to regard these glitches as potentially revealing of the art system, and even poetic at times. We also look at them as a way of revealing the inherent fallibility of the commercial use of AI and machine learning to catalogue the world: it cannot comprehend other ways of knowing about the world, outside the logic of the algorithm. But, at the same time, due to their “glitchy” capacity to level and reimagine, these faulty readings can also serve as a new way of reading art; a new way for thinking critically about the art image in a moment when visual culture has changed form to hybrids of human–machine cognition and “machine-to-machine seeing”. (shrink)