The International Agency for Research on Cancer (IARC) is an organization which seeks to identify the causes of human cancer. Per agent, such as betel quid or Human Papillomaviruses, they review the available evidence deriving from epidemiological studies, animal experiments and information about mechanisms (and other data). The evidence of the different groups is combined such that an overall assessment of the carcinogenicity of the agent in question is obtained. In this paper, we critically review the IARC’s carcinogenicity evaluations. First (...) we show that serious objections can be raised against their criteria and procedures – more specifically regarding the role of mechanistic knowledge in establishing causal claims. Our arguments are based on the problem of confounders, of the assessment of the temporal stability of carcinogenic relations, and of the extrapolation from animal experiments. Then we address a very important question, viz. how we should treat the carcinogenicity evaluations that were based on the current procedures. After showing that this question is important, we argue that an overall dismissal of the current evaluations would be too radical. Instead, we argue in favour of a stepwise re-evaluation of the current findings. (shrink)

How do Dutch people let each other know that they disagree? What do they say when they want to resolve their difference of opinion by way of an argumentative discussion? In what way do they convey that they are convinced by each other’s argumentation? How do they criticize each other’s argumentative moves? Which words and expressions do they use in these endeavors? By answering these questions this short essay provides a brief inventory of the language of argumentation in Dutch.

The use of coercion is morally problematic and requires an ongoing critical reflection. We wondered if not knowing or being uncertain whether coercion is morally right or justified (i.e. experiencing moral dou...

Today, mechanisms and mechanistic explanation are very popular in philosophy of science and are deemed a welcome alternative to laws of nature and deductive‐nomological explanation. Starting from Mitchell's pragmatic notion of laws, I cast doubt on their status as a genuine alternative. I argue that (1) all complex‐systems mechanisms ontologically must rely on stable regularities, while (2) the reverse need not hold. Analogously, (3) models of mechanisms must incorporate pragmatic laws, while (4) such laws themselves need not always refer to (...) underlying mechanisms. Finally, I show that Mitchell's account is more encompassing than the mechanistic account *Received August 2008; revised January 2010. †To contact the author, please write to: Centre for Logic and Philosophy of Science, Ghent University, Blandijnberg 2, B‐9000 Belgium; e‐mail: Bert[email protected]. (shrink)

In spite of the remarkable progress made in the burgeoning field of social neuroscience, the neural mechanisms that underlie social encounters are only beginning to be studied and could —paradoxically— be seen as representing the ‘dark matter’ of social neuroscience. Recent conceptual and empirical developments consistently indicate the need for investigations, which allow the study of real-time social encounters in a truly interactive manner. This suggestion is based on the premise that social cognition is fundamentally different when we are in (...) interaction with others rather than merely observing them. In this article, we outline the theoretical conception of a second-person approach to other minds and review evidence from neuroimaging, psychophysiological studies and related fields to argue for the development of a second-person neuroscience, which will help neuroscience to really go social; this may also be relevant for our understanding of psychiatric disorders construed as disorders of social cognition. (shrink)

The impressive young scholar Bert Mosselmans, analyzing the theory and policy of Jevons, a major figure in the field of the history of economics, has put together a volume with broad international appeal, particularly in Europe, North America and Japan, that offers a synthetic approach to Jevons’ economic theory, applied economics and economic policy. Adopting a relativist approach to his subject, Mosselmans focuses on all aspects of Jevons’ theory, tying the different strands together where appropriate and discriminating where necessary. (...) Examining the relation between theory and practise he situates Jevons within the history of economic thought and in relation to his logic, ethics, religion and aesthetics. Ideal for scholars working in the fields of philosophy and history as well as economics, this ambitious and insightful work offers a comprehensive analysis of one of the founding fathers of modern economic thought, whose work marked a new chapter in its history, bridging the gap between classical and neo-classical economics. (shrink)

In this article, I present two conceptual problems for Craver's mutual manipulability account of constitutive relevance in mechanisms. First, constitutive relevance threatens to imply causal relevance despite Craver (and Bechtel)'s claim that they are strictly distinct. Second, if (as is intuitively appealing) parthood is defined in terms of spatio-temporal inclusion, then the mutual manipulability account is prone to counterexamples, as I show by a case of endosymbiosis. I also present a methodological problem (a case of experimental underdetermination) and formulate two (...) partial, but fallible solutions based on the notions of parthood and synchronicity. (shrink)

This book discusses issues regarding conceptualization, governance and implementation of responsible innovation. It treats different approaches to making responsible innovation a reality and it contains new case studies that illustrate challenges and solutions. Research on Responsible Innovation is by its nature highly multidisciplinary, and also pro-active, design-oriented and policy-relevant. Until a few years back, the concept of Responsible Innovation was hardly used - nowadays it is increasingly receiving attention from both researchers and policy makers. This is indispensable reading for anyone (...) interested in or working on innovation. (shrink)

Clinical ethics support (CES) for health care professionals and patients is increasingly seen as part of good health care. However, there is a key drawback to the way CES services are currently offered. They are often performed as isolated and one-off services whose ownership and impact are unclear. This paper describes the development of an integrative approach to CES at the Center of Expertise and Care for Gender Dysphoria (CEGD) at Amsterdam University Medical Center. We specifically aimed to integrate CES (...) into daily work processes at the CEGD. In this paper, we describe the CES services offered there in detail and elaborate on the 16 lessons we learned from the process of developing an integrative approach to CES. These learning points can inform and inspire CES professionals, who wish to bring about greater integration of CES services into clinical practice. (shrink)

The most important modes of film practice, in my view, are art-house cinema and the avant-garde, both of which contrast with the classical Hollywood mode of film practice. While the latter is characterized by its commercial imperative, corporate hierarchies, and a high degree of specialization as well as a division of labor, the avant-garde is an “artisanal” or “personal” mode. Avant-garde films tend to be made by individuals or very small groups of collaborators, financed either by the filmmakers alone or (...) in combination with private patronage and grants from arts institutions. Such films are usually distributed through film cooperatives and exhibited by film societies, museums, and universities. (Consequently .. (shrink)

If one compares the development of modern medical ethics in Germany with those in the Netherlands, what stands out are the cultural and intellectual differences between the two countries. Dealing with the problems involved in limiting medical treatment, the authors show the differing and the common standards and values on which the discussion of this is based in both countries. Three examples, active termination of life, the do-not-resuscitate order and pain management, which are examined from an historical, legal, philosophical and (...) ethical perspective, put this in concrete terms. The authors belong to different generations as well as different political and philosophical camps. Vergleicht man die Entwicklung der modernen Medizinethik in Deutschland mit jener in den Niederlanden, fallen die kulturellen und intellektuellen Unterschiede zwischen beiden Landern deutlich auf. Anhand der Problematik der Begrenzung medizinischen Handelns zeigen die Autoren die verschiedenen bzw. gemeinsamen Normen und Werte, die der Diskussion daruber in beiden Landern zugrunde liegen. Drei Beispiele, die aktive Lebensbeendigung, die Nicht-Reanimierung und die Schmerzbekampfung, die aus historischem, juristischem, philosophischem und ethischem Blickwinkel betrachtet werden, konkretisieren die Darstellung. Die Autoren gehoren unterschiedlichen Generationen, politischen und lebensanschaulichen Lagern an. (shrink)

In the traditional African view, words and sentences are not viewed as being liable to objective reflective truth/falsehood-judgments. It is not a person-word-reality-view, but a person-word-person-view: the sender's words are units of orally produced energy that have the power to improve or degenerate the receiver's vitality. Words received can make you more powerful by increasing your confidence and your control over your environment. But they can equally well harm (parts of) you, by discouraging you in certain endeavors. From the traditional (...) African point of view, words are not logical, but physical phenomena: words are forces affecting power. (shrink)

Responsibility disappears into the background of private law as it deals with imputation of liability. Fitness to be held liable is determined by normative viewpoints different from moral ones, in particular by convictions on how society ought to be organized so as to avoid or end conflict between private citizens. Modes of discursive control are geared to making authoritative decisions in view of the same end, and corporate agency is created, restricted or enlarged to undercut or to impose individual liability.

The volume contributes to the ongoing nanoethics debate in four topical areas. The first part tackles questions of what could be called ‘meta-nanoethics’. Its focus lies on basic concepts and the issue of what - if anything - is truly novel and special about the new field of nanoethics or its subject matter. The second part of this volume presents a selection of interesting perspectives on some of the opportunities and challenges of nanotechnology. Part three takes a more in depth (...) look at one of the most pressing current concerns: how to deal with the risks and uncertainties surrounding nanotechnology in a responsible manner. In its fourth and final part the volume touches on issues of public debate and policy. (shrink)

Background Research on the impact of ethics reflection groups (ERG) (also called moral case deliberations (MCD)) is complex and scarce. Within a larger study, two years of ERG sessions have been used as an intervention to stimulate ethical reflection about the use of coercive measures. We studied changes in: employees’ attitudes regarding the use of coercion, team competence, user involvement, team cooperation and the handling of disagreement in teams. Methods We used panel data in a longitudinal design study to measure (...) variation in survey scores from multidisciplinary employees from seven departments within three Norwegian mental health care institutions at three time points (T0–T1–T2). Mixed models were used to account for dependence of data in persons who participated more than once. Results In total, 1068 surveys (from 817 employees who did and did not participate in ERG) were included in the analyses. Of these, 7.6% (N = 62) responded at three points in time, 15.5% (N = 127) at two points, and 76.8% (N = 628) once. On average, over time, respondents who participated in ERG viewed coercion more strongly as offending (p < 0.05). Those who presented a case in the ERG sessions showed lower scores on User Involvement (p < 0.001), Team Cooperation (p < 0.01) and Constructive Disagreement (p < 0.01). We observed significant differences in outcomes between individuals from different departments, as well as between different professions. Initial significant changes due to frequency of participation in ERG and case presentation in ERG did not remain statistically significant after adjustment for Departments and Professions. Differences were generally small in absolute terms, possibly due to the low amount of longitudinal data. Conclusions This study measured specific intervention-related outcome parameters for describing the impact of clinical ethics support (CES). Structural implementation of ERGs or MCDs seems to contribute to employees reporting a more critical attitude towards coercion. Ethics support is a complex intervention and studying changes over time is complex in itself. Several recommendations for strengthening the outcomes of future CES evaluation studies are discussed. CES evaluation studies are important, since—despite the intrinsic value of participating in ERG or MCD—CES inherently aims, and should aim, at improving clinical practices. (shrink)

Many theories about human number representation stress the importance of a central semantic representation that includes the magnitude information of small integer numbers, and that is conceived as an abstract, compressed number line. However, thus far there has been little or no direct evidence that units and teens are represented on the same number line. In two masked priming experiments, we show that single-digit and two-digit Arabic numerals are equally well primed by an Arabic numeral with the same number of (...) digits as by an equally distant Arabic numeral with a different number of digits (e.g. the priming effect of 7 on the target 9 is the same as the priming effect of 11 on the target 9). The finding was obtained both with a number naming task and with a parity judgement task. This is in line with the hypothesis that units and teens are part of a continuous number line. (shrink)

We investigate how conventional asset managers account for environmental, social, and governance factors in their investment process. We do so on the basis of an international survey among fund managers. We find that many conventional managers integrate responsible investing in their investment process. Furthermore, we find that ESG information in particular is being used for red flagging and to manage risk. We find that many conventional fund managers have already adopted features of responsible investing in the investment process. Furthermore, we (...) argue and show that ESG investing is highly similar to fundamental investing. We also reveal that there is a substantial difference in the ways in which U.S. and European asset managers view ESG. (shrink)

Mechanistic approaches are very common in the causal interpretation of biological and neuroscientific experimental work in today’s philosophy of science. In the mechanistic literature a strict distinction is often made between causal relations and constitutive relations, where the latter cannot be causal. One of the typical reasons for this strict distinction is that constitutive relations are supposedly synchronic whereas most if not all causal relations are diachronic. This strict distinction gives rise to a number of problems, however. Our end goal (...) in this paper is to argue that it should be given up, at least in the context of the biological and the psychological sciences. To that effect, we argue that constitutive relations in this context are diachronic, thus undermining the aforementioned reason. We offer two cases from scientific practice in which constitutive relations are regarded as both diachronic and causally efficacious, review three existing ways of dealing with the apparent diachronic nature of interlevel relations in mechanisms and propose a new account of diachronic, causal constitutive relevance. (shrink)

In this paper, I examine whether the use of artificial intelligence (AI) and automated decision-making (ADM) aggravates issues of discrimination as has been argued by several authors. For this purpose, I first take up the lively philosophical debate on discrimination and present my own definition of the concept. Equipped with this account, I subsequently review some of the recent literature on the use AI/ADM and discrimination. I explain how my account of discrimination helps to understand that the general claim in (...) view of the aggravation of discrimination is unwarranted. Finally, I argue that the use of AI/ADM can, in fact, increase issues of discrimination, but in a different way than most critics assume: it is due to its epistemic opacity that AI/ADM threatens to undermine our moral deliberation which is essential for reaching a common understanding of what should count as discrimination. As a consequence, it turns out that algorithms may actually help to detect hidden forms of discrimination. (shrink)

In light of the increasing refusal of some parents to vaccinate children, public health strategies have focused on increasing knowledge and awareness based on a “knowledge-deficit” approach. However, decisions about vaccination are based on more than mere knowledge of risks, costs, and benefits. Individual decision making about vaccinating involves many other factors including those related to emotion, culture, religion, and socio-political context. In this paper, we use a nationally representative internet survey in the U.S. to investigate socio-political characteristics to assess (...) attitudes about vaccination. In particular, we consider how political ideology and trust affect opinions about vaccinations for flu, pertussis, and measles. Our findings demonstrate that ideology has a direct effect on vaccine attitudes. In particular, conservative respondents are less likely to express pro-vaccination beliefs than other individuals. Furthermore, ideology also has an indirect effect on immunization propensity. The ideology variable predicts an indicator capturing trust in government medical experts, which in turn helps to explain individual-level variation with regards to attitudes about vaccine choice. (shrink)

This paper exploits the language of structuralism, as it has recently been developed with stunning effectiveness in defining the relations between confirmation, empirical progress and truth approximation, to concisely clarify the fundamental problem of the classical Lakatos concept of scientific progress, and to compare its way of evaluation to the real problems of scientists facing the far from perfect theories they wish to improve and defend against competitors.I opt basically for the structuralist terminology adopted in Kuipers (2000), because that is (...) balanced with care to deal with a range of issues far wider than the one dealt with in this contribution. It should be added that this does not commit me to any position on any subject, because structuralism is not a (meta-) theory, it is a language, able to express anything that can be said in other concept systems created to describe knowledge and its dynamics. (shrink)

"This wholeheartedly interdisciplinary book explores the possibility of domain specific cooperation between philosophy and psychology concerning questions on spatial representation. Its leitmotif is the importance of movement in concord with the workings of the body schema. Against the background of embodiment, situatedness, and Susan Hurley's notion of a ninety-degree shift it is spelled out how true, domain specific cooperation between the disciplines can be accomplished. By enriching Grush's naturalistic account of representation (emulation theory) with insights stemming from teleosemantics, the notion (...) of the body schema is clarified and connected to the notion of a nonconceptual point of view. Translating this latter notion into three key capacities allows to draw on insights from neuroscience concerning place cells, head-direction cells, and grid cells. These cell types can be mapped on our key capacities, which shows that the nonconceptual point of view already is apparent on a very low level of analysis. Elaborating on Evans's notion of a travel-based space allows to sketch an account of spatial representation underwritten by the importance of movement and emulation and helps us to grasp spatial content's special framework role. Moreover, it provides a satisfying answer to the question of how a representation of space might be built up that enables higher-level cognition, yet, stands in continuity to sensorimotor research."--Publisher's description. (shrink)

The philosophical essays collected here are predicated on the conviction that we live in a time when all-encompassing philosophical systems can no longer be seriously entertained as a true reflection of extant reality. Instead, an indefinite number of perspectives on - or discursive appropriations of - what is thought of as 'reality' are possible. Sometimes they diverge and sometimes they intersect in surprising ways, as these essays show. While the belief in an all-inclusive philosophical system is rejected, the author shows (...) that every perspective displays a coherence and illuminating power of its own.<BR> The collection is divided into two parts. The first considers philosophy, the individual and society, covering themes including the deleterious effects of capitalism on natural ecosystems, the modern conception of 'immortality' in Nietzsche's thought, Lacan's provocative interpretation of capitalist discourse, the current status of the humanities in universities, individual autonomy, the meaning of 'identification', global 'terrorism', and Plato's philosophical self-subversion. The second part gathers together perspectives on the arts and society, with the author arguing that reflections on cinema, architecture and music never isolate these arts from social concerns, but demonstrate their interconnectedness. (shrink)

The essays assembled in this volume focus on philosophical questions regarding various aspects of communication.

monsters, virtual legends such as 2001’s HAL or Demon Seed’s Proteus are actually scary because of their mind. Without lingering on the philosophical debates on whether a certain type of mind can exist independent of its specific embodiment or whether any creature can understand a consciousness that is not like his own (recall Lem’s Solaris), the thing that makes HAL and Proteus so human is not so much their ability to think as their possessing something resembling human consciousness. The point (...) is that, whereas consciousness may or may not be required for an artificial agent to think, it is an essential element in creating anything resembling a human-like thinker that would pass the Turing Test. (shrink)

A significant part of everyday learning occurs incidentally — a process typically described as implicit learning. A central issue in this and germane domains such as language acquisition is the extent to which performance depends on the acquisition and deployment of abstract rules. In an attempt to address this question, we show that the apparent use of such rules in a simple categorisation task of artificial grammar strings, as reported by Shanks, Johnstone, and Staggs (1997), can be simulated by means (...) of a simple recurrent network, and may thus turn out not be incompatible with the acquisition of statistical regularities rooted in the processing of exemplars of the presented material. (shrink)

Recently, moral deliberation within care institutions is gaining more attention in medical ethics. Ongoing dialogues about ethical issues are considered as a vehicle for quality improvement of health care practices. The rise of ethical conversation methods can be understood against the broader development within medical ethics in which interaction and dialogue are seen as alternatives for both theoretical or individual reflection on ethical questions. In other disciplines, intersubjectivity is also seen as a way to handle practical problems, and methodologies have (...) emerged to deal with dynamic processes of practice improvement. An example is responsive evaluation. In this article we investigate the relationship between moral deliberation and responsive evaluation, describe their common basis in dialogical ethics and pragmatic hermeneutics, and explore the relevance of both for improving the quality of care. The synergy between the approaches is illustrated by a case example in which both play a distinct and complementary role. It concerns the implementation of quality criteria for coercion in Dutch psychiatry. (shrink)

The field of medicine is generally greeted with great enthusiasm. This can be witnessed in the immense support for medical progress, which is widely hoped to lead to a realization of idealized goals. Indeed, with the help of medicine the human body would be controllable and constructible, human nature perfectible. However, enthusiasm in favor of medical progress is first and foremost a sentiment and, like all sentiments, not necessarily a product of rational contemplation. People are capable of enthusing about the (...) realization of utopian notions, such as life without disease or with the perfect body, without requiring any concrete arguments to back them up. Enthusiasm alone is not a guarantee of ethical desirability, however. Hence, this book takes a closer look at four research fields often referred to in medical utopian literature: 'tissue engineering', 'bioelectronics', 'germ line genome modification' and 'interventions in the biological aging process'. They serve as a basis for analyzing whether ethical arguments can be found to support the euphoric advocacy of the further development of these fields. (shrink)

At the bottom of all human activities are “values,” the conviction that some things “ought to be” and others not. Science, however, with its immense interest in mere facts seems to lack all understanding of such‘requiredness.’… A science … which would seriously admit nothing but indifferent facts … could not fail to destroy itself.

Little is known about how health care professionals deal with ethical challenges in mental health care, especially when not making use of a formal ethics support service. Understanding this is important in order to be able to support the professionals, to improve the quality of care, and to know in which way future ethics support services might be helpful.

Ethicists differ considerably in their reasons for using empirical data. This paper presents a brief overview of four traditional approaches to the use of empirical data: “the prescriptive applied ethicists,” “the theorists,” “the critical applied ethicists,” and “the particularists.” The main aim of this paper is to introduce a fifth approach of more recent date (i.e. “integrated empirical ethics”) and to offer some methodological directives for research in integrated empirical ethics. All five approaches are presented in a table for heuristic (...) purposes. The table consists of eight columns: “view on distinction descriptive-prescriptive sciences,” “location of moral authority,” “central goal(s),” “types of normativity,” “use of empirical data,” “method,” “interaction empirical data and moral theory,” and “cooperation with descriptive sciences.” Ethicists can use the table in order to identify their own approach. Reflection on these issues prior to starting research in empirical ethics should lead to harmonization of the different scientific disciplines and effective planning of the final research design. Integrated empirical ethics (IEE) refers to studies in which ethicists and descriptive scientists cooperate together continuously and intensively. Both disciplines try to integrate moral theory and empirical data in order to reach a normative conclusion with respect to a specific social practice. IEE is not wholly prescriptive or wholly descriptive since IEE assumes an interdepence between facts and values and between the empirical and the normative. The paper ends with three suggestions for consideration on some of the future challenges of integrated empirical ethics. (shrink)

Introduction. Bert HAMMINGA and Neil DE MARCHI: Préface. Bert HAMMINGA and Neil DE MARCHI: Idealization and the Defence of Economics: Notes Toward a History. Part I: General Observations on Idealization in Economics. Kevin D. HOOVER: Six Queries about Idealization in an Empirical Context. Bernard WALLISER: Three Generalization Processes for Economic Models. Steven COOK and David HENDRY: The Theory of Reduction in Econometrics. Maarten C.W. JANSSEN: Economic Models and Their Applications. Adolfo GARCÍA DE LA SIENRA: Idealization and Empirical Adequacy (...) in Economic Theory. Izabella NOWAKOWA and Leszek NOWAK: On Correspondence between Economic Theories. Uskali MÄKI: Isolation, Idealization and Truth in Economics. Part II: Case Studies of Idealization in Economics. Nancy CARTWRIGHT: Mill and Menger: Ideal Elements and Stable Tendencies. Wolfgang BALZER: Exchange Versus Influence: A Case of Idealization. Kees COOLS, Bert HAMMINGA, Theo A.F. KUIPERS: Truth Approximation by Concretization in Capital Structure Theory. Daniel M. HAUSMAN: Paul Samuelson as Dr. Frankenstein: When an Idealization Runs Amuck. Hugo A. KEUZENKAMP: What if an Idealization is Problematic? The Case of the Homogeneity Condition in Consumer Demand. Werner DIEDERICH: Nowak on Explanation and Idealization in Marx's 'Capital'. Gérard JORLAND: Idealization and Transformation. Jack BIRNER: Idealizations and Theory Development in Economics. Some History and Logic of the Logic Discovery. Discussions. Leszek NOWAK: The Idealizational Methodology and Economics. Replies to Diederich, Hoover, Janssen, Jorland and Mäki. (shrink)