Biosimilar drugs enter the United States market well after they enter the European market. That is likely because pharmaceutical companies have many more patents in the United States than in Europe. But why is patent coverage of biological drugs so much more extensive in United States? This case study seeks to answer this question for drug formulation patents.

Dans le texte de 1922 « Vom Chaos zur Wirklichkeit » («Du Chaos à la Réalité », 1922, 14 pp.), pour Carnap, la description du Chaos est inaccessible. Le chaos est « le point de départ irrationnel de notre théorie » (p. 1 du tapuscrit). La réalité est toujours déjà une construction logique. Pour autant postuler un chaos, comme degré zéro de la réalité, favorise le projet d’une description de l’étayage logique à partir du rien. La grammaire de la réalité (...) est le postulat de la description logique évitant ainsi tout recours à un fondement métaphysique. Notre article montre comment en partant du chaos, Carnap fonde peu à peu la constitution du corps. (shrink)

t. 1. Le chaos, le temps, le principe anthropique -- t. 2. Les interprétations de la physique quantique -- t. 3. Complexité, vie, conscience.

« Comme toute grande philosophie, celle de Deleuze avant Guattari et avec Guattari renouvelle la définition de la pensée. Depuis Différence et répétition, la pensée n’est pour Deleuze ni naturelle ni spontanée, elle est le produit d’une genèse : Deleuze part d’une critique de l’image représentative de la pensée qui lui permet de dégager le vrai commencement de la pensée, ses conditions réelles. Avec cette genèse, grâce à laquelle la pensée se cherche un sol autre que la représentation en renonçant (...) en même temps à tout fondement, Deleuze résout, pour son propre compte, le problème du commencement en philosophie, en faisant surgir une pensée sans image. Par la suite, Deleuze et Guattari construisent ensemble une nouvelle métaphysique qui semble se passer, en apparence seulement, des notions d’image de la pensée et de pensée sans image. En réalité, à l’unique « Image de la pensée » qu’il s’agissait de détruire dans Différence et répétition, Deleuze et Guattari substituent, dès Mille plateaux, une pluralité d’images de la pensée, chacune étant historiquement et singulièrement déterminée. Ils esquissent même dans cet ouvrage l’idée d’une « noologie » qu’ils prendraient pour objet d’étude. Ces images deviendront les plans d’immanence de Qu’est-ce que la philosophie?. Quant à la pensée sans image, nous montrerons que, loin de disparaître, elle prend différentes formes, notamment celle du chaos, dans leur dernier ouvrage. Notre hypothèse est donc que, sous des vocables changeants, ces deux idées, comme leur relation mise à jour par Deleuze, ne disparaissent pas de leur métaphysique commune. ». (shrink)

Insights into the problem of our relation to language Kenneth Burke and Contemporary European Thought: A Rhetoric in Transition reflects the present transitional nature of rhetoric and society. Its purpose is to relate the rhetorical theory of Burke to the theories of four major European philosophers--Jürgen Habermas, Ernesto Grassi, Foucault, and Jacques Derrida--as they discuss the nature of language and its central role in society. This book describes a rhetorical world in transition but not a world in chaos. It points (...) to the centrality of symbolism in theories of language and rhetoric and illustrates Burke's influence as a pivotal things and theorist in the communication arts and sciences, suggesting that the observations regarding shifting paradigms and perspectives made by other scholars are indeed emergent in the realm of rhetoric. It also regards the powerful impact of language and symbolic action in both the critique and construction of human knowledge and augurs a central role for rhetoric in the intellectual and social transformations of this and the next century. (shrink)

This account of the dynamical theory of chaos leads to a metaphysical picture of a world with an open future, in which the laws of physics are emergent‐downward approximations to a more subtle and supple reality and in which there is downward causation through information input as well as upward causation through energy input. Such a metaphysical picture can accommodate both human and divine agency.

The language theory of Mikhail Bakhtin does not fall neatly under any single rubric - 'dialogism,' 'marxism,' 'prosaics,' 'authorship' - because the philosophic foundation of his writing rests ambivalently between phenomenology and Marxism. The theoretical tension of these positions creates philosophical impasses in Bakhtin's work, which have been neglected or ignored partly because these impasses are themselves mirrored by the problems of antifoundationalist and materialist tendencies in literary scholarship. In Mikhail Bakhtin: Between Phenomenology and Marxism Michael Bernard-Donals examines various (...) incarnations of phenomenological and materialist theory - including the work of Jauss, Fish, Rorty, Althusser, and Pecheux - and places them beside Bakhtin's work, providing a contextualised study of Bakhtin, a critique of the problems of contemporary critics, and an original contribution to literary theory. (shrink)

The piRNA class of small RNAs are distinct from other small RNAs by their ∼26–31 nucleotide size, single‐strandedness and strand‐specificity as well as by the clustered arrangement of their origins. Here, we highlight how these features are reminiscent of the mechanisms of DNA replication, and then present three models suggesting that the origin of piRNAs may be mechanistically similar to key processes in DNA replication. BioEssays 29:382–385, 2007. © 2007 Wiley Periodicals, Inc.

For many philosophers working in the area of Population Ethics, it seems that either they have to confront the Repugnant Conclusion , or they have to confront the Non-Identity Problem . To them it seems there is no escape, they either have to face one problem or the other. However, there is a way around this, allowing us to escape the Repugnant Conclusion, by using what I will call Negative Average Preference Utilitarianism – which though similar to anti-frustrationism, has some (...) important differences in practice. Current “positive” forms of utilitarianism have struggled to deal with the Repugnant Conclusion, as their theory actually entails this conclusion; however, it seems that a form of Negative Average Preference Utilitarianism easily escapes this dilemma. (shrink)

The purposes of research were to describe the neonatal clinicians' personal views and attitudes on neonatal ethical decision-making, to identify factors that might affect these attitudes and to compare the attitudes between neonatal physicians and neonatal nurses in Taiwan. Research was a cross-sectional design and a questionnaire was used to reach different research purposes. A convenient sample was used to recruit 24 physicians and 80 neonatal nurses from four neonatal intensive care units in Taiwan. Most participants agreed with suggesting a (...) do not resuscitate (DNR) order to parents for dying neonates (86.5%). However, the majority agreed with talking to patients about DNR orders is difficult (76.9%). Most participants agree that review by the clinical ethics committee is needed before the recommendation of ‘DNR’ to parents (94.23%) and nurses were significantly more likely than physicians to agree to this (p=0.043). During the end-of-life care, most clinicians accepted to continue current treatment without adding others (70%) and withholding of emergency treatments (75%); however, active euthanasia, the administration of drug to end-of-life, was not considered acceptable by both physicians and nurses in this research (96%). Based on our research results, providing continuing educational training and a formal consulting service in moral courage for neonatal clinicians are needed. In Taiwan, neonatal physicians and nurses hold similar values and attitudes towards end-of-life decisions for neonates. In order to improve the clinicians' communication skills with parents about DNR options and to change clinicians' attitudes for providing enough pain-relief medicine to dying neonates, providing continuing educational training and a formal consulting service in moral courage are needed. (shrink)

With the rise of China in the global economy, it has never been more important for business leaders to understand Chinese leadership philosophies and practices. This is the first book to explain how ancient Chinese thinking and Western ideas have shaped the development of leadership styles in China. Leadership theories associated with Confucianism, Daoism, Legalism, the Arts of War, and the writings of Mao and Deng are analysed by both Chinese and Western experts. To set this in a modern business (...) context, the book includes interviews with top executives, who reflect on how their business values are affected by ancient Chinese philosophers, modern Chinese leaders, and Western management writers and thinkers. The book also includes research on paternalistic leadership as practised by business leaders in Taiwan, Hong Kong, and mainland China. (shrink)

The scholastic philosopher is interested in definition for a different reason than the lexicographer and linguist. The philosopher is trying to learn things. Fe defines, after investigating reality, in an attempt to describe reality clearly and to sum up some aspect of his understanding of reality. Hence, we find our scholastic philosophers adopting as a main feature of their method this insistence on defining, on precise and detailed explanation of their definitions, and on proving that their definitions da correctly express (...) what a nature or activity is. A dictionary of the language of scholastic philosophy fitted to the needs of beginners and of undergraduate students of the subject is not available in English. (shrink)

For some decades, the concept of human dignity has been widely discussed in bioethical literature. Some authors think that this concept is central to questions of respect for human beings, whereas others are very critical of it. It should be noted that, in these debates, dignity is one component of a long-lasting and widespread conceptual construct used to support a stance on the ethical question of the moral status of an action or being. This construct has been used from Modernity (...) onward to condemn slavery and torture as violations of human dignity. In spelling it out, we can come to a better understanding of what “dignity” means and become aware that there exists a quite useful place for this notion in our ethical thought, albeit a modest one. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

At the end of the sixteenth century astronomers and others felt compelled to choose among different cosmologies. For Tycho Brahe, who played a central role in these debates, the intersection of the spheres of Mars and the Sun was an outstanding problem that had to be resolved before he made his choice. His ultimate solution was to eliminate celestial spheres in favour of fluid heavens, a crucial step in the abandonment of the Ptolemaic system and the demise of Aristotelian celestial (...) physics. These debates involved issues that had not previously been part of astronomy, and had the effect of undermining the traditional hierarchy of the sciences. While this complicated story involves many scientific personalities of the sixteenth and seventeenth centuries, in the present paper we will concentrate on one figure who has been assigned an unnecessarily minor role in most histories of science: Christoph Rothmann. In the present paper we show that ‘the dissolution of the celestial spheres’ depends on arguments about the substance of the heavens, following a mistaken argument of Gemma Frisius, elaborated by Joannes Pena and appropriated by Rothmann. We next consider the status and origin of the doctrine, as presented by Brahe, that the heavenly spheres are solid, and the impact on Brahe of Rothmann's treatise on the comet of 1585. Rothmann provided several key ideas that enabled Brahe to develop his system, and we suggest in passing that Rothmann may also have precipitated Brahe's re-evaluation of his attempt to detect the parallax of Mars during the opposition of 1582–83. We offer a new account of this central piece of evidence for the Tychonic system. (shrink)

Direction of the embyro's head rotation is determined by asymmetrical expression of several genes (such as shh, Nodal, lefty, and FGF8) in Hensen's node. This genetically determined head-turning bias provides a base for light-aligned population lateralization in chicks, in which the direction of the lateralization is determined by genetic factors and the degree of the lateralization is determined by environmental factors.

We designed an experiment to test the application of optimality theory (OT) in kinship terminology studies. Specifically, we examined the OT constraints within a set of behavioral data using Chinese kin terms. The results from this behavioral approach support and extend Jones' linguistic approach by identifying underlying cognitive mechanisms that can explain and predict behavioral responses in kinship identification.

This paper uses E. M. Forster’s novel Howards End to help articulate what I describe as a moral pluralist approach to moral conflict. Moral pluralism, I argue here, represents a way of responding to the moral conflicts we encounter in our lives, rather than the mere acknowledgment of their inevitability, as suggested by value pluralists like Isaiah Berlin. The tragic view of moral conflict epitomized by Sophocles’ Antigone and endorsed by most theories of value pluralism, tells us that we must (...) choose between moral commitments and reconcile ourselves to the moral regrets that inevitably follow from moral choice. The moral pluralist view, in contrast, suggests that we should seek means, however imperfect, of satisfying conflicting moral commitments and minimizing causes for moral regret. That view, I argue, drives the words and actions of Forster’s heroine in Howards End, Margaret Schlegel. Confronted with a battle between a willful patriarch and a self-righteous sister, a conflict that maps neatly onto the central conflict in Sophocles’ tragedy, Margaret refuses to take sides without refusing to make moral choices. And in doing so, she comes to exemplify an unexpected kind of moral heroism. (shrink)

Although Hobbes talks about the laws of nature as prescribing the virtues, it is easier to think of them as proscribing the vices. The nine vices that are proscribed by the laws of nature are injustice, ingratitude, greed or inhumanity, vindictiveness , cruelty, incivility or contumely, pride, arrogance, and unfairness . The corresponding virtues that are prescribed by the laws of nature are justice, gratitude, humanity or complaisance, mercy, , civility, humility, , modesty, and equity. The difficulty of coming up (...) with names for some of the virtues, and even for some of the vices, shows that they are not all among the most common moral virtues and vices. Nonetheless, as described by Hobbes, they are genuine moral virtues and vices, traits of character such that all impartial rational persons would favor everyone having the virtues and no one having the vices. All of these virtues are such that they benefit everyone impartially by promoting peace, and are not primarily of benefit to the person having them. This is what makes them moral virtues and distinguishes them from the personal virtues of courage, prudence, and temperance. The laws of nature are the dictates "of right reason, conversant about those things which are either to be done or omitted for the constant preservation of life and members, as much as in us lies." But the law of nature "dictating peace, for a means of the conservation of men in multitudes;" is also the moral law because "in the means to peace, [it] commands also good manners, or the practice of virtue; and therefore it is called moral." Hobbes correctly sees both that peace benefits all persons impartially and that impartiality is essential to morality. His account of the moral virtues correctly makes them traits of character that would be favored by all impartial persons. His argument for the rationality of these moral virtues is that one's self-interest, which for Hobbes is primarily one's long-term preservation, is enhanced by having these virtues. There is no incompatibility between morality and self-interest as long as what is in one's own self-interest is equally in the interest of everyone else. Hobbes sees this point quite clearly and it is at the heart of his justification of the moral virtues. (shrink)