The immune system does not just fight pathogens but also engages in interactions with beneficial microbes and non-immune cells of the body to harmonize their behavior by means of cytokines, antibodies and effector cells (Dinarello, 2007; Moticka, 2015, pp. 217e226, 261e267). However, the importance of these “housekeeping” functions has not been fully appreciated (Cohen, 2000). In his new book Immunity: The Evolution of an Idea Alfred I. Tauber traces the history of fundamental ideas in immunology and refers to recent advances (...) in the field to overturn the notion that immunity is the ability of an autonomous organism to protect itself against pathogens. Indeed, as suggested by the author, the autonomy of the organism is illusive because individuals develop as holobionts: functionally integrated multispecies consortia (p. 98). Similarly, he suggests that pathogenicity also emerges from the lack of subordination of a microbe to social welfare of the holobiont rather than from context-independent properties of this organism (pp. 165, 181). Emphasizing the contextual character of the parasite and the host, Tauber redefines immunity as an active process of coordination of a cellular ecosystem, which allows this collective to navigate through challenges of the environment and to face demands of the communal living (pp. 10e16). From this point of view, the failure to modulate intercellular interactions by the immune system entails mitigating immunity and impairing resistance to infection and disease (pp. 103e104). Immunity is a groundbreaking work establishing a new framework for understanding the function and activity of the immune system. Its value also lies in the fact that it serves as an important stepping-stone towards an integrated philosophical, ecological and immunological study of our embedment in the microbial world. (shrink)

Philosophy of immunology is a subfield of philosophy of biology dealing with ontological and epistemological issues related to the studies of the immune system. While speculative investigations and abstract analyses have always been part of immune theorizing, until recently philosophers have largely ignored immunology. Yet the implications for understanding the philosophical basis of organismal functions framed by immunity offer new perspectives on fundamental questions of biology and medicine. Developed in the context of history of medicine, theoretical biology, and medical anthropology, (...) philosophy of immunology differs from these related branches of study in its focus on traditional philosophical questions concerning identity, individuality, ecology, cognition, scientific methodology and theory construction. This broad agenda derives from immunology’s multifaceted research program that has developed from its initial clinical challenges of host defense, transplantation, autoimmunity, tumor immunology, and allergy. In addition to these well-established research areas, immunity is now understood to play a central role in other physiological functions, development, ecology, and evolutionary mechanics. Holding together these diverse domains of inquiry lie philosophical commitments oriented by organismal identity. In this regard, pertinent issues are raised concerning cognition (organization of immune perception and information processing), the character of individuality (framed by the ecological context of immune-mediated assimilation and rejection), and the dynamics of complex systems (understood as holistic systems biology). Indeed, immunology, in the context of cognitive science, evolutionary biology, environmental sciences, and development provides multi-focal perspectives for philosophy of science. (shrink)

It has long been taken for granted that the immune system’s capacity to protect an individual from infection and disease depends on the power of the system to distinguish between self and nonself. However, accumulating data have undermined this fundamental concept. Evidence against the self/nonself discrimination model left researchers in need of a new overarching framework able to capture the immune system’s reactivity. Here, I highlight that along with the self/nonself model, another powerful representation of the immune system’s reactivity has (...) been developed in the twentieth century immunology. According to this alternative view, the immune system is not a killer of nonself strangers but a peace-maker helping to establish harmony with the environment. The balance view of the system has never become part of the dominant paradigm. However, it is gaining more and more currency as new research develops. Advances in mucosal immunology confirm that instead of distinguishing between self and foreign the immune system reacts to microbial, chemical and self-induced alterations to produce responses that counterbalance effects of these changes. (shrink)

The extent to which normal (nonmalignant) cells of the body can evolve through mutation and selection during the lifetime of the organism has been a major unresolved issue in evolutionary and developmental studies. On the one hand, stable multicellular individuality seems to depend on genetic homogeneity and suppression of evolutionary conflicts at the cellular level. On the other hand, the example of clonal selection of lymphocytes indicates that certain forms of somatic mutation and selection are concordant with the organism-level fitness. (...) Recent DNA sequencing and tissue physiology studies suggest that in addition to adaptive immune cells also neurons, epithelial cells, epidermal cells, hematopoietic stem cells and functional cells in solid bodily organs are subject to evolutionary forces during the lifetime of an organism. Here we refer to these recent studies and suggest that the expanding list of somatically evolving cells modifies idealized views of biological individuals as radically different from collectives. (shrink)

Somatic diversification of antigen receptor genes depends on the activity of enzymes whose homologs participate in a mutagenic DNA repair in unicellular species. Indeed, by engaging error-prone polymerases, gap filling molecules and altered mismatch repair pathways, lymphocytes utilize conserved components of genomic stress response systems, which can already be found in bacteria and archaea. These ancient systems of mutagenesis and repair act to increase phenotypic diversity of microbial cell populations and operate to enhance their ability to produce fit variants during (...) stress. Coopted by lymphocytes, the ancient mutagenic processing systems retained their diversification functions instilling the adaptive immune cells with enhanced evolvability and defensive capacity to resist infection and damage. As reviewed here, the ubiquity and conserved character of specialized variation-generating mechanisms from bacteria to lymphocytes highlight the importance of these mechanisms for evolution of life in general. (shrink)

At the dawn of the computational era, immunology is at a crossroads: Its efforts to frame microbial-host interactions in combative, war-related terms no longer fit the larger picture of immune protection, and its focus on antimicrobial responses barely captures the diverse functions of the immune system, from tissue maintenance to cancer surveillance to development. As the classical view of immune processes becomes increasingly complex, the problem of self, individuality, mind-body interactions, and disease causation have stimulated extensive philosophical comment. Relating these (...) disparate research topics to changing avenues of theoretical studies, philosophy of immunology helps to reframe basic conceptions of the organism from an atomistic, insular entity to one characterized by fluidity, hybridity, and porosity. In addition, highlighting the role of the observer in experimental research, this interdisciplinary field has redefined classical demarcations between science and culture while advancing our understanding of biology as a fundamentally human endeavor. (shrink)

[Przekład] Pogląd głoszący, że układ odpornościowy rozróżnia to, co swoje, od tego, co obce, był jednym z centralnych założeń immunologii w drugiej połowie XX wieku. Pogląd ten miał wpływ na projekty eksperymentalne i interpretowanie danych. Jednakże w obliczu nowych dowodów empirycznych konieczny jest w immunologii nowy aparat konceptualny.

There are philosophers of mind who believe that externalism with regard to mental content leads inevitably to the conclusion, that the mind should be identified with something external to the cognitive system. These philosophers are convinced that contents of our thoughts are not located in our heads on the basis of Putnam's belief that the contents of linguistic expressions are not located in head. The aim of this paper is to show that despite the above widespread convictions, externalism with regard (...) to mental content allows to identify mental states with the states of the cognitive system. If the question regarding the localization of the mind makes any sense, the mind has to be identified with the entity located within the cognitive system of an individual. I will show that an externalist is not in a position to identify the mental with contents of representational states of the cognitive system. She is unable to identify the mind and mental states with physical bearers too. What is the common mistake of these two options is an unacceptable idealization according to which it is possible to separate content from a bearer. The only possible option that externalist could embrace is the one that says that a mental state should be identified with physical bearers bearing content. Such bearers are the physical objects that thanks to the system in which they exist can stand for other objects. Form the externalistic point of view this power of standing for something is determined, at least partially, by external factors. (shrink)

To enable microbial colonisation of the gut mucosa, the intestinal immune system must not only react to danger signals but also recognize cues that indicate safety. Safety recognition, paradoxically, is mediated by the same environmental sensors that are involved in signalling danger. Indeed, in addition to their well established role in inducing inflammation in response to stress signals, pattern recognition receptors (PRRs) and a variety of metabolic sensors also promote gut-microbiota symbiosis by responding to "microbial symbiosis factors", "resolution-associated molecular patterns", (...) markers of energy extraction and other signals indicating the absence of pathogenic infection and tissue damage. Here we focus on how the paradoxical role of immune receptors and other environmental sensors define the microbiota signature of the individual. (shrink)

The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

Commensal and pathogenic organisms employ camouflage and mimicry to mediate mutualistic interactions and predator escape. However, the immune mechanisms accounting for the establishment and maintenance of symbiotic bacterial populations are poorly understood. A promising hypothesis suggests that molecular mimicry, a condition in which different organisms share common antigens, is a mechanism of establishing tolerance between commensals and their hosts. On this view, certain bacteria may mimic the structural features of some of their host’s T-cell receptors (TCRs), namely those that survive (...) thymic selection due to their lack of complementarity to self-antigens. With such “holoimmunity” the mimicking micro-organisms avoid immune recognition as the copied TCRs become mirror images of an extended super-organismal self, consisting of symbiotic and host antigens. Accordingly, analysis of genomic and metagenomic data suggests a tripartite mimicry between TCRs, self-antigens, and commensal antigens that would serve as the basis for immune tolerance between these populations. And conversely, in an autoimmune scenario, both symbiotic microbes and the mimicked host tissue would be targeted for immune destruction. (shrink)

Advocates of the computational theory of mind claim that the mind is a computer whose operations can be implemented by various computational systems. According to these philosophers, the mind is multiply realisable because—as they claim—thinking involves the manipulation of syntactically structured mental representations. Since syntactically structured representations can be made of different kinds of material while performing the same calculation, mental processes can also be implemented by different kinds of material. From this perspective, consciousness plays a minor role in mental (...) activity. However, contemporary neuroscience provides experimental evidence suggesting that mental representations necessarily involve consciousness. Consciousness does not only enable individuals to become aware of their own thoughts, it also constantly changes the causal properties of these thoughts. In light of these empirical studies, mental representations appear to be intrinsically dependent on consciousness. This discovery represents an obstacle to any attempt to construct an artificial mind. (shrink)

Central to vaccination-induced responses, antibodies are suggested by Vaz to operate as observer-dependent entities that owe their status to categorization schemes of immunologists. Inspired by color research by Maturana, he argues that antibodies should be distinguished from immunoglobulins, which unlike the former can be considered as constituents of structural dynamics of an organism, products of millions of years of evolution. However, a deeper understanding of the historical roots of the concept of immunoglobulin and associated “languaging” and naming processes reveals that (...) immunoglobulins, as much as antibodies, are contingent on conceptual schemes of immunology. (shrink)

Originating in the work of Ernst Haeckel and Wilhelm Preyer, and advanced by a Prussian embryologist, Wilhelm Roux, the idea of struggle for existence between body parts helped to establish a framework, in which population cell dynamics rather than a predefined harmony guides adaptive changes in an organism. Intended to provide a causal-mechanical view of functional adjustments in body parts, this framework was also embraced later by early pioneers of immunology to address the question of vaccine effectiveness and pathogen resistance. (...) As an extension of these early efforts, Elie Metchnikoff established an evolutionary vision of immunity, development, pathology, and senescence, in which phagocyte-driven selection and struggle promote adaptive changes in an organism. Despite its promising start, the idea of somatic evolution lost its appeal at the turn of the twentieth century giving way to a vision, in which an organism operates as a genetically uniform, harmonious entity. (shrink)

Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli (...) influence the course of immune activation. (shrink)

One of the fundamental questions of life sciences is one of whether there are genuinely random biological processes. An affirmative or negative answer to this question may have important methodological consequences. It appears that a number of biological processes are explicitly classified as random. One of them is the so-called somatic hypermutation. However, closer analysis of somatic hypermutation reveals that it is not a genuinely random process. Somatic hypermutation is called random because the exact outcome of this process is difficult (...) to predict in practice. The case of somatic hypermutation suggests that there may be no scientific evidence of a single case of ontologically random process in the biological world. (shrink)

The idea that the immune system distinguishes between self and non-self was one of the central assumptions of immunology in the second half of 20 th century. This idea influenced experimental design and data interpretation. However, in the face of new evidence there is a need for a new conceptual framework in immunology.

Immunity by William Paul is an overview of fundamental principles of immunology and their experimental basis. The book includes not only well- established facts about the immune system but also recent findings (the role of Th17 cells, regulatory T cells, inflammasomes, etc.), which are skillfully incorporated into the framework of immunological understanding. The presentation is clear and emotionally charged, which makes the reading of Immunity enjoyable. Despite the original intentions, though, the book may appear too challenging for a lay reader (...) to serve as a popular introduction to immunology. Instead, it may help to put already acquired immunological knowledge in order benefiting advanced biology students and researchers. At a deeper level, Immunity provokes questions concerning what counts as relevant and what counts as a landmark in immunology. (shrink)

There is a deep-seated neopositivist view which regards the language of science as a neutral medium of communication, radically different from indirect symbolic forms of discourse characteristic of arts and humanities. But naturalists, like poets and social scientists, also draw on the dominant images in their culture to organize their thoughts and simplify complex concepts. By conceptualizing one thing in terms of another, metaphors in science not only aid mutual communication between researchers but also structure their understanding of experience and (...) reality. Too transparent to be noticed and critically analyzed within the framework of science itself, metaphors act as lenses, making selected aspects of complex phenomena visible to study and investigation (Reynolds 2018). By linking two seemingly unrelated ideas, for example, those of a machine and DNA replication, metaphors establish new interactions of meaning evoking shared associated connotations between these interacting concepts (Black 1962). This, in turn, may not only transform the perception of a target domain but also open up new prospects for experimental and interpretative avenues. Understanding Metaphors by Andrew Reynolds draws on this vision of metaphors as indispensable tools of scientific thinking to elucidate their role in the life sciences. (shrink)

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

Author: Sipiński Bartłomiej Title: THE PHENOMENOLOGICAL EXPRESSION OF THE ESSENCE OF THE PERSON (Fenomenologiczne określenie Osoby) Source: Filo-Sofija year: 2006, vol:.6, number: 2006/1, pages: 91-100 Keywords: PERSON, MAX SCHELER, PHENOMENOLOGY, PHENOMENOLOGICAL EXPRESSION Discipline: PHILOSOPHY Language: POLISH Document type: ARTICLE Publication order reference (Primary author’s office address): E-mail: www:The main problem of this article is a try to find the meaning of an essence of the Person. Asking about the Person in colloquial meaning is asking about the cultural pattern of (...) the Person at the same time. What can be helpful in leaving the cultural pattern of the Person without leaving an essence of problem known as a Person, but difficult to indicate without an example? Answer at this question, will be probably similar with finding an essence of the Person as a pure comprehension. Phenomenology, as a finding of certainty can be a method in that “personalistic adventure”, especially in version of the German phenomenologist – Max Scheler, who was trying to explain comprehension of the Person from the emotional point of view. Emotions, which can be understood as a phenomenon of the Person appearing in the practical function, and creating a culture with its examples of the Person, and finally giving its place in non personal surrounding world. Here appears solution. By using Scheler’s method describing the Person from the emotional side, it seems to be possible to separate the pure comprehension from the cultural pattern of the Person. That shows another reduction, next to well known reductions in Phenomenology. It could be something like an emotional reduction, which separates the Person from non personal structure of surrounding world and not gives a cultural pattern of the Person at the same time. The next move is building a dialogue as a relation between Persons, which defines them as a dialogical subjects. (shrink)

Abstract:Non-anthropocentric approaches to environmental ethics face problems that cannot be resolved within a holistic framework of natural value since such frameworks posit abstract and general properties as the bearers of intrinsic value and thus ignore the moral claims of individual organisms. Two paradigm examples of such approaches, Aldo Leopold's Land Ethic and Arne Neass' Deep Ecology suffer from this problem. Christine Korsgaard's argument for the conceptual separation of intrinsic and instrumental valuing, however, serves as a strong theoretical grounding for a (...) reconceptualization of the value of nature, which can best be described as an enlightened anthropocentrism, while preserving the spirit of Leopold's and Naess' proposals. (shrink)

This paper argues, against the prevailing view, that consent to privacy policies that regular internet users usually give is largely unproblematic from the moral point of view. To substantiate this claim, we rely on the idea of the right not to know (RNTK), as developed by bioethicists. Defenders of the RNTK in bioethical literature on informed consent claim that patients generally have the right to refuse medically relevant information. In this article we extend the application of the RNTK to online (...) privacy. We then argue that if internet users can be thought of as exercising their RNTK before consenting to privacy policies, their consent ought to be considered free of the standard charges leveled against it by critics. (shrink)

It is frequently argued that false and misleading claims, spread primarily on social media, are a serious problem in need of urgent response. Current strategies to address the problem – relying on fact-checks, source labeling, limits on the visibility of certain claims, and, ultimately, content removals – face two serious shortcomings: they are ineffective and biased. Consequently, it is reasonable to want to seek alternatives. This paper provides one: to address the problems with misinformation, social media platforms should abandon third-party (...) fact-checks and rely instead on user-driven prediction markets. This solution is likely less biased and more effective than currently implemented alternatives and, therefore, constitutes a superior way of tackling misinformation. (shrink)

This paper argues that the well-established fact of political irrationality imposes substantial constraints on how governments may combat the threat of political misinformation. Though attempts at regulating misinformation are becoming increasingly popular, both among policymakers and theorists, I intend to show that, for a wide range of anti-misinformation interventions (collectively termed “debunking” and “source labeling”), these attempts ought to be abandoned. My argument relies primarily on the fact that most people process politically-relevant information in biased and motivated ways. Since debunking (...) or factual correction of politically relevant misinformation (as well as source labeling) themselves consist of providing politically-relevant information, they are also very likely to be processed in irrational ways. This makes it extremely difficult to effectively correct people’s political beliefs and political information processing. Since governments should not pursue policies likely to be futile, they should refrain from mandating such interventions. My conclusion is of relevance to considerable literature in digital ethics of misinformation. It shows that many celebrated works in the field ignore political irrationality and fail to consider its implications. (shrink)

Philosophers have no time. They are tired with philosophising. They doze off or even die of fatigue over yet another review, opinion, article, translation of works of an English-speaking philosophical genius, publishing and editing of a book. They are exhausted by the obligatory teaching, bored with listening to conference papers, depressed by defences of post-doctoral theses, hopeless against plagiarism, out-of-breath chasing credits, worn out by English articles, crumpled and ill-treated by institutions, tired with maintaining and co-creating them, jaded by the (...) speed of information transfer, weakened by the absence of lively thought, knackered by the number of graduates and languid due to their quality, depressed by discord, exhausted by the continuous game of getting lost and finding oneself in science and the Academy. -/- In this ruffle, shabbiness and depletion they undertake with difficulty yet another fight for philosophy, in which they often represent the lost cause and happen to be merciless to each other, sometimes they give up and even moan. Their tiredness is accompanied by heavy steps and sluggishness. Barely alive they keep on living. Somewhere they find the energy, they live for something, serve something. In the article, following the smartest of philosophers, Socrates, and his defence speech, the speech in defence of his life, we explain where the philosophers find the energy, what they live for and what, often in contradiction to their own declarations, they serve. (shrink)

This Dissertation argues for a care-centrically grounded account of relational personhood and widely realized diachronic personal identity. The moral distinction between persons and non-persons is arguably one of the most salient ethical lines we can draw since many of our most fundamental rights are delineated via the bounds of personhood. The problem with drawing such morally salient lines is that the orthodox, rationalistic definition of personhood, which is widespread within philosophical, medical, and colloquial spheres, excludes, and thereby de-personifies, a large (...) number and a great variety of human beings such as neonates, young children, the elderly who suffer from dementia, individuals with severe cognitive disabilities, and patients in vegetative states. The reconceptualization of personhood necessary for a more inclusive definition ought to originate with an appropriate moral grounding. To this end, this Dissertation grounds the notion of personhood in the care ethical sphere, thereby emphasizing the role of care relations in the maintenance of the moral consideration of vulnerable individuals. This Dissertation argues that grounding the concept of a person in care relations entails a relational account of personhood, which, along with the insights of the Extended Mind and Social Manifestation Theses, leads to an extended and externalized understanding of diachronic identity, which allows fragile people to be held in their personal identities even if they themselves lack the capacities usually associated with moral personhood. As we trace a person’s identity through time, we track the various relational properties, which constitute personal narratives and thus act as a glue that binds such dynamic and often unique properties into stable, trackable narratives. Since care relations are morally relevant on a care-centric account of personhood, what is lost in cases where such care relating ceases is not merely of sentimental value, but of great moral importance as well. Morally meaningful care relations are not replaceable, and, by extension, neither are the narratives that are constituted by such unique and irreplaceable instances of relating. This Dissertation argues that the constitutive care relational nature of personal narratives makes such narratives irreplaceable and is precisely what makes persons so morally precious. (shrink)

The Metaphysics of Cooperation presents the intellectual achievements of the Polish associative socialist and pioneer of social sciences, Edward Abramowski. The volume is divided into five sections, each of them contains an analysis of Polish philosopher's work according to the issues he dealt with: sociology, ethics, politics, cooperativism, and psychology. Each part also contains a selection of his writings. Its intention is to show Abramowski's works in the context of global intellectual history and to include them in the current political (...) debates. Abramowski makes fraternity or cooperation the main concepts of his social metaphysics. The Polish version of cooperativism can be inspiring both for contemporary researchers and political activists in the post-economic-crisis Europe. It also opens up a space for creating more democratic political and economic institutions. (shrink)

Streszczenie: Idea sacrum w lirycznej twórczości Dariusza Dekańskiego to konglomerat wielu składowych. Zarówno rzeczywistości konsystencjalnej, jak i tej sensytywnej – wyobrażonej, percypowanej na drodze synestezji. W prezentowanym artykule, pełniącym rolę asumptu do dalszych badań nad poetycką aktywnością autora Saudade, zwrócono szczególną uwagę na więź człowieka z Bogiem, kontakt z sacrum, przejawiającymi się w wewnętrznych przeżyciach podmiotu lirycznego, bezustannie szukającego swojego miejsca w świecie. Aby zbliżyć się do zrozumienia działań bohatera tej poezji wykorzystano przede wszystkim instrumentarium oferowane przez metodologie badań sacrum.

Journal of Applied Philosophy, EarlyView.

While the Philosophy for Children method has been adopted within classrooms by individual teachers and into some school systems by schoolboards, public and school libraries, the ideal users of this sort of programming, have been slow to recognise the benefits of this didactic methodology. This is particularly surprising given that the P4C method integrates perfectly with traditional story-time orientated programming. Not only is the integration of P4C into story-time sessions virtually seamless, but it might also help reinvigorate a well-established feature (...) of library programming with an aim to develop 21st-century information literacy competencies. This paper examines the case for the P4C method, explains the process of integration of the P4C method with traditional story-time, and highlights the potential benefits of incorporating Philosophy for Children in public and school library programming. (shrink)

Genealogia jest tą nauką pomocniczą historii, która od pewnego już czasu obecna jest w cyberprzestrzeni. Deklasuje pod tym względem inne nauki pomocnicze historii, które pozostają daleko w tyle chociażby pod względem liczby wyświetleń w przeglądarce, będących efektem wyszukiwania stron internetowych. Stanowi to konsekwencję popularności badań genealogicznych, które w ostatnim czasie prowadzone są w znaczącej mierze nie przez naukowców, ale pasjonatów i genealogów-amatorów, którzy samodzielnie chcą zgłębiać historię swoich rodzin, a co za tym idzie – tworzyć rodzinne kompendia genealogiczne. O takim, (...) a nie innym ukierunkowaniu badań świadczą także różnego rodzaju poradniki, które w ostatnim czasie ukazały się na polskim rynku wydawniczym. Oferują one czytelnikowi zarówno omówienie tradycyjnych narzędzi wykorzystywanych w badaniach genealogicznych, jak i tych nowoczesnych, związanych z postępem technologicznym i przedstawianiem informacji w formie cyfrowej. W rezultacie w niemal każdej tego typu publikacji zamieszczony został rozdział poświęcony charakterystyce funkcjonujących w Internecie serwisów i baz danych, które stanowią nieocenioną pomoc w badaniach genealogicznych. Są nią także różnego rodzaju profile i grupy w mediach społecznościowych, które do tej pory pozostawały jednak niezauważone, tak przez naukowców, jak i popularyzatorów. Z tego też względu niniejszy artykuł poświęcony zostanie syntetycznemu omówieniu obecności genealogii w cyberprzestrzeni, zarówno w skali makro (duże serwisy i bazy internetowe), jak i mikro (niewielkie grupy w mediach społecznościowych). Celem artykułu jest bowiem ukazanie genealogii jako tej z nauk pomocniczych historii, która nie tylko odnalazła się w świecie cyfrowym, ale w nim zadomowiła i wciąż się rozwija. (shrink)

Genealogia jako dziedzina wiedzy badająca więzy rodzinne, zarówno te wynikające z filiacji, jak i te stanowiące konsekwencje małżeństwa, jest tą z nauk pomocniczych historii, która pozwala m.in. spojrzeć na portretowaną w biografii osobę z perspektywy relacji z poszczególnymi członkami rodziny, jak i miejsca, które dana osoba w kręgu rodzinnym zajmowała. Nie inaczej jest w przypadku wojewody krakowskiego Mikołaja Zebrzydowskiego (1553–1620), którego postać od pewnego już czasu wzbudza coraz większe zainteresowanie badaczy. Jedni skupiają się na jego działalności politycznej, w tym przede (...) wszystkim na wywołanym przez magnata rokoszu, drudzy tematem swoich prac uczynili religijność wojewody i bezpośrednio z nią związaną działalność fundacyjną, inni zaś skupili się na kwestiach o charakterze genealogicznym, w tym na pokazaniu Zebrzydowskiego w kręgu jego rodzinny, zarówno tej najbliższej, jak też dalszej. W ostatni w wyżej wymienionych nurtów wpisuje się niniejszy artykuł, który stanowi odpowiedź na pojawiające się w literaturze nieścisłości dotyczące związków małżeńskich Mikołaja Zebrzydowskiego. W opublikowanych ostatnio pracach pojawiła się bowiem informacja o dwóch małżeństwach wojewody krakowskiego, z których pierwsze miał zawrzeć z nieznaną z imienia kobietą, drugie zaś z Dorotą z Herburtów, która zmarła w 1610 r. Stanowi to konsekwencję niepoprawnie przetłumaczonego, a następnie źle zinterpretowanego wpisu z Metryki Koronnej, o czym też szerzej traktuje niniejszy artykuł. Zawarte we wpisie sformułowanie _ad secundas nuptias _odnosi się bowiem do mogącego zaistnieć w przyszłości hipotetycznego związku małżeńskiego, który łączyłby wdowę po Mikołaju Zebrzydowskim – Dorotę z Herburtów, z innym mężczyzną. Tym samym wpis w Metryce Koronnej nie odnosi się do związków małżeńskich wojewody, a co za tym idzie nie mówi nic o jego rzekomych dwóch małżeństwach. (shrink)

Having been involved in a slew of recent scandals, many of the world’s largest technology companies embarked on devising numerous codes of ethics, intended to promote improved standards in the conduct of their business. These efforts have attracted largely critical interdisciplinary academic attention. The critics have identified the voluntary character of the industry ethics codes as among the main obstacles to their efficacy. This is because individual industry leaders and employees, flawed human beings that they are, cannot be relied on (...) voluntarily to conform with what justice demands, especially when faced with powerful incentives to pursue their own self-interest instead. Consequently, the critics have recommended a suite of laws and regulations to force the tech companies to better comply with the requirements of justice. At the same time, they have paid little attention to the possibility that individuals acting within the political context, e.g. as lawmakers and regulators, are also imperfect and need not be wholly compliant with what justice demands. This paper argues that such an omission is far from trivial. It creates a heavy argumentative burden on the part of the critics that they by and large fail to discharge. As a result, the case for Big Tech regulation that emerges from the recent literature has substantial lacunae and more work needs to be done before we can accept the critics’ calls for greater state involvement in the industry. (shrink)

This article examines the use of mathematical concepts in philosophy, focusing on topology, which may be viewed as a modern supplement to geometry. We show that Plato and Parmenides were already employing geometric ideas in their research, and discuss three examples of the application of topology to philosophical problems: the first concerns the analysis of the Cartesian distinction between res extensa and res cogitans, the second the ontology of possible worlds of Wittgenstein's Tractatus, and the third Leibniz's monadology. We also (...) consider the role of topology in mathematical explanations of the sort found in science, arguing that it can perform a role in philosophy that is of comparable importance. (shrink)