Research over the last decades has stimulated a paradigm shift in biology from assuming fixed and dichotomous male and female sexual strategies to an appreciation of significant variation in sex and sexual behaviour both within and between species. This has resulted in the development of a broader biological understanding of sexual strategies, sexuality and variation in sexual behaviour. However, current introductory biological textbooks have not yet incorporated these new research findings. Our analysis of the content of current biology texts suggests (...) that in undergraduate biology curricula variation in sexual behaviour, sexual strategies and sexuality barely feature, even though sex is discussed in a range of contexts. In this aspect, biological teaching is lagging behind current research. Here, we draw attention to new findings in the biology of sex, and suggest how these might be incorporated in undergraduate teaching to provide a more contemporary and inclusive education for biology students. (shrink)

Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL (...) change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials. (shrink)

Research using mHealth apps has the potential to positively impact health care management and outcomes. However, choosing an appropriate mHealth app may be challenging for the health researcher. The author team used existing evaluation tools, checklists, and guidelines to assess selected mHealth apps to identify strengths, challenges, and potential gaps within existing evaluation tools. They identified specific evaluation tool components, questions, and items most effective in examining app content, usability, and features, including literacy demand and cultural appropriateness; technical information; practical (...) aspects of app functionality; and evolving capabilities of mobile medical apps. Challenges included the subjective nature of the results, time required to complete the evaluation, lack of emphasis on evidence‐based content, and inadequate tool flexibility. Health researchers considering the integration of mobile apps into research will benefit from evaluation tools that assess both evidence‐based content and the ability of the mobile app to securely integrate with other digital technologies involved in patient care. Next steps will include the involvement of health care providers and professionals, including nurses a wide range of expertise, to develop an mHealth evaluation tool that focuses on identifying quality, evidence‐based mobile apps into patient outcomes research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Frederick J. Streng Book Award:An Interview with Paul Ingram and Sallie KingSallie B. King and Paul O. IngramSallie King and Paul Ingram have been named winners of the 2003 Frederick J. Streng Book Award for their edited collection The Sound of Liberating Truth: Buddhist-Christian Dialogues in Honor of Frederick J. Streng (Curzon, 1999). Sallie King is professor of philosophy and religion at James Madison University (...) in Harrisonburg,Virginia. Paul Ingram is professor of religion at Pacific Lutheran University in Tacoma,Washington. Both are past presidents of the Society for Buddhist-Christian Studies. There is some irony that they have won this award named after Fred Streng, one of the founders of the Society for Buddhist-Christian Studies, for a volume that is a essentially a festschrift honoring the work of Fred Streng. Following is an edited interview with both of the winners.Buddhist-Christian Studies: What made each of you want to put together this collection of essays?Paul Ingram: Before I met Fred at the first "East-West Religions in Encounter" meeting organized by David Chappell in 1980 in Hawai'i, I was well acquainted with his work in history of religions. Fred by this time was recognized as one of the most important scholars in the field, and I deeply admired his work, particularly his book on Nagarjuna. As it turns out, he had read some of my work on Pure Land Buddhism and was as interested in meeting me as I was in meeting him. We became friends and colleagues. Because of our mutual interest in interreligious dialogue in general and in Buddhism in particular, he suggested that we should co-edit a volume of selected papers from the 1980 conference. This volume, Buddhist-Christian Dialogue: Mutual Renewal and Transformation, was subsequentlypublishedby the Universityof Hawai'i Press in 1986 and is still in print.Sallie King: I had long admired Fred's book on Nagarjuna, which uniquely and powerfullyopenedup the religiousmeaningof Nagarjuna'swork.I later metFred through the Society for Buddhist-Christian Studies and discovered that this admirable scholar was also a most admirable human being. We had lengthy, in-depth conversations when our paths crossed at various conferences. After Fred died, David Chappell, who had become the president of the Society for Buddhist-Christian Studies, suggested to Paul and me that we edit a volume of this kind in honor of Fred. Neither Paul nor I hesitated. For my part, I felt such a loss when Fred died that I was very happy [End Page 313] and honored to have this opportunity to make a gesture of respect and gratitude toFred.Besides his obvious scholarly achievements, what were Fred Streng's other gifts?PI: Fred was always generous in his support of colleagues. Many of us in the Society for Buddhist-Christian Studies are where we are professionally because of Fred's celebration of our work in all its diversity. He was one of the founding members of the Society, and he worked long and hard to make it a place for not only scholarly Buddhist-Christian encounter, but also a venue for nonspecialists to engage in Buddhist-Christian dialogue. All of us have been creatively transformed by Fred's work. After Fred's death in 1993, David Chappell invited Sallie and me to co-edit a volume of essays to honor Fred's memory and celebrate his work. We did so gladly and without reservation.SK: Fred was a very balanced person who had seriously engaged with all the important areas of human life. He was profoundly spiritual, seriously concerned about social issues, unfailingly kind and generous to others. Though he was at the top of his field, he remained straightforward and natural and always met even far-junior scholars as equals; he could not have been more encouraging and supportive. His spirituality, his scholarship, his engagement with social issues and his caring for others were all interdependent, mutually constructive of who he was and of his various projects.Were assignments for the book difficult to make?PI: The most difficult problem was selecting who to invite. Sallie and I identified five themes in Fred's scholarship, and we needed... (shrink)

Engaged Buddhism is the contemporary movement of nonviolent social and political activism found throughout the Buddhist world. Its ethical theory sees the world in terms of cause and effect, a view that discourages its practitioners from becoming adversaries, blaming or condemning the other. Its leaders make some of the most important contributions in the Buddhist world to thinking about issues in political theory, human rights, nonviolence, and social justice. Being Benevolence provides for the first time a rich overview of the (...) main ideas and arguments of prominent Engaged Buddhist thinkers and activists on a variety of questions: What kind of political system should modern Asian states have? What are the pros and cons of Western "liberalism"? Can Buddhism support the idea of human rights? Can there ever be a nonviolent nation-state? It identifies the roots of Engaged Buddhist social ethics in such traditional Buddhist concepts and practices as interdependence, compassion, and meditation, and shows how these are applied to particular social and political issues. It illuminates the movement’s metaphysical views on the individual and society and goes on to examine how Engaged Buddhists respond to fundamental questions in political theory concerning the proper balance between the individual and society. The second half of the volume focuses on applied social-political issues: human rights, nonviolence, and social justice. (shrink)

ABSTRACT This essay reviews major areas of ethical debate with regard to biodefense, focusing on cases in which biodefense presents ethical problems that diverge from those presented by naturally‐occurring outbreaks of infectious disease. It concludes with a call for ethicists to study not only the ethical issues raised in biodefense programs, but also the ethics of biodefense more generally.

Karma and its consequences are a major theme in Buddhism. When discussing war and peace in a Buddhist context, it is important to distinguish Buddhist philosophy from the practice of Buddhists in historical and present fact. This is because Buddhist philosophy on the subject, especially in the teachings of the Buddha and the mainstream Mahāyāna teachings, so heavily emphasizes non‐violence. The advent of engaged Buddhism places the dilemma of Buddhist violence in a new context. In so far as it does (...) not compromise the non‐violent and non‐particularist ideals of Buddhism, engaged Buddhism is an ongoing experiment in reconciling Buddhism's ideals with the reality of Buddhist behavior, in translating Buddhist personal ethics into a social ethic, and in determining how far Buddhist non‐violence can be taken on the societal level. (shrink)

Nostra Aetate has played a major role in fostering positive Buddhist-Christian relations. Buddhist-Christian dialogue differs from Christianity’s other inter-religious dialogues both due to Buddhism’s non-theistic assumptions and due to the primary locus of post-conciliar dialogue: the dialogue of religious experience among contemplative monastics. The decision to concentrate on monastics as a Buddhist-Catholic bridge continues to bear fruit, not only for larger Buddhist-Catholic relations but for the academic study of mysticism. The author discusses the experiences of the Trappist monk Thomas Merton, (...) the landmark Naropa Institute conferences, and other institutionalized Catholic outreach to Buddhist monastics. John Paul II’s remarks about Buddhism in Crossing the Threshold of Hope were a low point and setback in dialogue; the author evaluates these remarks and their consequences. (shrink)

The modern use of algebra to describe geometric ideas is discussed with particular reference to the constructions of Grassmann and Hamilton and the subsequent algebras due to Clifford. An Einstein addition law for nonparallel boosts is shown to follow naturally from the use of the representation-independent form of the geometric algebra of space-time.

In "The Law of Peoples", John Rawls proposes a set of principles for international relations, his "Law of Peoples." He calls this Law a "realistic utopia," and invites consideration of this Law from the perspectives of non-Western cultures. This paper considers Rawls's Law from the perspective of Engaged Buddhism, the contemporary form of socially and politically activist Buddhism. We find that Engaged Buddhists would be largely in sympathy with Rawls's proposals. There are differences, however: Rawls builds his view from the (...) idea of independent nation--states, while the Buddhists see the world more in terms of a single humankind, the members being highly interdependent with one another, and also with the physical world. The Buddhists would also push harder than Rawls for global structures building multilateralism, restrict more severely justifications for war and behavior in war, stress economic justice more heavily, and insist on all the human rights in the Universal Declaration of Human Rights. (shrink)

When our society holds widely shared norms and values, we can agree on what constitutes unethical business practices. To the extent our social consensus is unraveling, agreement becomes increasingly problematic. Unfortunately, mainstream Western moral philosophy offers no guidance in this situation. We must therefore begin to focus on the types of social relationships that must exist for there to be agreement on what is right, good and just. This line of argument is, at best, merely suggested in discussions and articles (...) on business ethics. (shrink)

Several prominent voices have called for a democratization of science through deliberative processes that include a diverse range of perspectives and values. We bring these scholars into conversation with extant research on democratic deliberation in political theory and the social sciences. In doing so, we identify systematic barriers to the effectiveness of inclusive deliberation in both scientific and political settings. We are particularly interested in what we call misidentified dissent, where deliberations are starkly framed at the outset in terms of (...) dissenting positions without properly distinguishing the kinds of difference and disagreement motivating dissent. (shrink)

A four-factor model of spiritual intelligence is first proposed. Supportive evidence is reviewed for the capacities of critical existential thinking, personal meaning production, transcendental awareness, and conscious state expansion. Based on this model, a 24-item self-report measure was developed and modified across two consecutive studies . The final version of the scale, the Spiritual Intelligence Self-Report Inventory , displayed excellent internal reliability and good fit to the proposed model. Correlational analyses with additional measures of meaning, metapersonal self-construal, mysticism, religiosity, and (...) social desirability offer support for construct and criterion-related validity. According to both intelligence criteria and current psychometric standards, findings validate the proposed model and measure of spiritual intelligence. Future directions are discussed. (shrink)

While it is common to observe that our society and world are becoming increasingly complex and fast paced, most of our theories provide no bases upon which to develop appropriate strategies. The need for developing holistic strategies is becoming urgent in two related areas: major interactive technologies and morality.

This thesis is a translation, with notes and introduction, of the Commentary to the Hua-yan Dharma-Realm Meditation. This text is a commentary to the Dharma-Realm Meditation, which is incorporated into the former. The core text is by the first patriarch of the Hua-yan school of Buddhism in China, Du-shun (557-640); the commentary is by the fifth patriarch of the Hua-yan school, Zong-mi (780-841). The text is both philosophical and meditational in nature, and is a concise statement of the key doctrines (...) of the school. -/- The introduction to this text prepares the reader for the translation by providing the information and concepts necessary for an understanding of the text. This includes material on the translation of technical terms, a brief sketch of some Buddhist texts referred to by the authors, biographical information on the authors, historical and philosophical background to the Hua-yan school, a commentary on the literary and meditational aspects of the text, and a general summary of the text by chapters. (shrink)

The linguistic expression of religious experience is problematic for both the experiencer and the philospher. For instance: is the religious experience nonverbal, i.e. does it utterly transcend all words, concepts, and thought? Or is it ineffable – not amenable to verbal expression? In either case, what can one make of all the talk and writings of those who do report religious experiences? The frequent references to ineffability, transcendence of thought and the like, lead one to wonder if the experiencers themselves (...) are not dis-satisfied with these expressions. If this is indeed the case, what is it about these expressions that produces this dissatisfaction? Are some expressions better suited to the experience than others? (shrink)

Recently, ethicists have posited that consideration of epigenetic mechanisms presents novel challenges to concepts of justice and equality of opportunity, such as elevating the importance of environments in bioethics and providing a counterpoint to gross genetic determinism. We argue that new findings in epigenetic sciences, including those regarding intergenerational health effects, do not necessitate reconceptualization of theories of justice or the environment. To the contrary, such claims reflect a flawed understanding of epigenetics and its relation to genetics that may unintentionally (...) undermine appeals to social justice. We provide a brief summary of epigenetic sciences, focusing on phenomena central to the current ethical discourse. We identify three fallacious modes of reasoning arising from the emergent literature on the ethical and policy implications of epigenetics, including mischaracterization, undue extrapolation, and exceptionalism. We end by discussing how these issues may work against mobilizing health equity policies and present a more modest claim regarding the value of new epigenetic knowledge to health justice by setting this discourse within the context of known themes in biomedical ethics and health policy. (shrink)

As levels of trust decrease and the necessity for trust increase in our society, we are increasingly driven toward the untoward, even disastrous, outcomes of the prisoner's dilemma. Yet despite the growing evidence that (re)building conditions of trust is increasingly mandatory in our era, modern moral philosophy (by default) and the social sciences (implicitly) legitimize an instrumental rationality which is the root problem. The greatest danger is that as conditions of trust are rationalized away through the progressive institutionalization of an (...) instrumental rationality, we are driven towards the most virulent form of the prisoner's paradox — ethical relativism and its nihilistic consequences. (shrink)

Many Liberal Quakers have taken Buddhism into their spiritual lives, drawing primarily upon its meditation methods and its philosophy. How does this fit with Quakerism’s Christian foundations? Buddhist meditation methods are used to help Quakers touch a spiritual depth, but between Buddhist and Quaker religious experience a question arises: are meditative/mystical states natural, or do they require an Other, God, as agent? This issue is related to contemporary Liberal Quaker ambiguous feelings about “God” language and frequent preference for words like (...) “Light” and “Spirit.” Buddha Nature and Inner Light both represent the immanence of the transcendent, but how similar are these concepts? Nondualistic Buddhist philosophy is a resource for those Quakers who find that “God” language does not adequately capture their spiritual experience. (shrink)

‘Harm reduction’ programs are usually justified on the utilitarian grounds that they aim to reduce the net harms of a behavior. In this paper, I contend that the historical genesis of harm reduction programs, and the crucial moral imperative that distinguishes these programs from other interventions and policies, are not utilitarian; the practical implementation of harm reduction programs is not, and probably cannot be, utilitarian; and the continued justification of harm reduction on utilitarian grounds is untenable and may itself cause (...) harm. Promoting harm reduction programs as utilitarian in the public arena disregards their deeper prioritarian impulses. ‘Harm reduction’ is a misnomer, and the name should be abandoned sooner rather than later. (shrink)

Our methods of inquiry predetermine most of what we are able to know. While our modes of understanding ought to correspond to the complexities confronting us in our modern technological society, they do not. “Soft” systems methodology helps us focus on what is problematic and how it can be approached — and offers direction to exert moral control over our tools and technologies. [Powerful new technologies] pose basic threats to people and to life on Earth . . . Unless we (...) learn to live with them in safety, our future is likely to be both exciting and short. We cannot hope to foresee all the problems ahead, yet by paying attention to the big, basic issues, we can perhaps foresee the greatest challenges and get some idea of how to deal with them (K. Erik Drexler, 1986). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 127-150 [Access article in PDF] They Who Burned Themselves for Peace: Quaker and Buddhist Self-Immolators during the Vietnam War Sallie B. KingJames Madison UniversityNhat Chi Mai was a lay disciple of Thich Nhat Hanh and member of the Order of Interbeing, an Engaged Buddhist order founded by Nhat Hanh. On May 16, 1967, Vesak, the celebration of the birth of the Buddha, she burned herself (...) to death outside the Tu Nghiem Temple, a nunnery. An idealistic young student with much to live for, she sacrificed herself in an effort to bring the war to an end. In a letter to the U.S. government she wrote, I offer my body as a torch to dissipate the dark to waken love among men to give peace to Vietnam the one who burns herself for peace. 1In her farewell letter to Thich Nhat Hanh she wrote, "Thay, don't worry too much. We will have peace soon." 2On November 2, 1965, Norman Morrison, a devout Quaker and ardent pacifist, drove from Baltimore to Washington and burned himself to death at the Pentagon, at a spot estimated to be 40 to 100 feet from the window of Robert S. McNamara, then Secretary of Defense and one of the chief American prosecutors of the war. Shortly before his death, he wrote to his wife, "For weeks even months I have been praying only that I be shown what I must do. This morning with no warning I was shown.... Know that I love thee but must act...." 3 Morrison took his baby daughter, Emily, along with him and held her in his arms as he prepared for his act. Somehow--accounts differ as to how it happened--she was separated from her father before the flames engulfed him and she emerged entirely unharmed, though her clothing smelled strongly of the kerosene with which Morrison had soaked himself. 4There were others who burned themselves to death during the war in Vietnam. The venerable Buddhist monk Thich Quang Duc was the first. On June 11, 1963, [End Page 127] at a downtown crossroads in Saigon, he sat in the lotus posture and, in a state of meditative control, burned himself to death in protest of the Diem regime's repression of the Buddhist religion. Many Vietnamese Buddhist monks and nuns followed his example; I do not know all their names, or exactly how many they were.In America, to my knowledge, eight people burned themselves to death during the war. Two were Quakers: Norman Morrison and Alice Herz. Roger LaPorte, a former Trappist seminarian who had become a Catholic worker, burned himself to death one week after Norman Morrison. The others were: Hiroko Hayasaki, a Japanese-American Buddhist; Erik Thoen, a student of Zen Buddhism; another university student, George Winne; a high school student, Ronald Brazee; and Florence Beaumont, described as a "housewife." A number of others attempted self-immolation but survived. 5In this paper I will focus upon the self-immolations of Norman Morrison and Nhat Chi Mai. I will also have a few comments on Thich Quang Duc. My remarks are intended, however, to have relevance to all the Buddhist and Quaker self-immolators. 6Let us now consider in more detail some of the features of the self-immolations of Norman Morrison and Nhat Chi Mai, and some of the issues they pose to the Quaker and Buddhist communities, respectively. Precipitating Events While neither act was the result of a moment's impulse, we still would do well to ask what events most proximately precipitated the two self-immolations. In Norman Morrison's case, the precipitating events were two. The morning of the day he immolated himself he read a report of the American bombing of a village in Vietnam. Paris Match had published an interview with a French priest, recuperating in a Saigon clinic, who had witnessed and survived the bombing raid. The priest said, "I have seen my faithful burned up in napalm.... I have seen... (shrink)

Three general types of problems entail different strategies. Continuing to seek solutions to tame problems when we face messes, let alone wicked problems, is potentially catastrophic hence fundamentally irresponsible. In our turbulent times, it is therefore becoming a strategic necessity to learn how to solve the right problems. Successful problem solving requires finding the right solution to the right problem. We fail more often because we solve the wrong problem than because we get the wrong solution to the right problem. (...) Russell Ackoff (1974). But then, you may agree that it becomes morally objectionable for the planner to treat a wicked problem as though it were a tame one, or to tame a wicked problem prematurely, or to refuse to recognize the inherent wickedness of social problems. Rittel and Webber (1973). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Dialogue:Looking Back, Looking Ahead, and Listening Ever More DeeplySallie B. KingI was asked to give a brief overview of the subject of the Buddhist-Christian dialogue, looking back over its history and looking ahead to its future. I begin with two caveats. First, of necessity, this account will be very general and I will paint with a very broad brush. I cannot speak to the many variations and exceptions (...) to many, if not all, of the general statements that I make. Second, inevitably, this account will also be very subjective. It will especially be colored by my visits in recent years to Sri Lanka, Thailand, and Taiwan.the dialogue on religious thoughtLooking back over the history of the Buddhist-Christian dialogue, one notices a pattern that is regularly remarked upon: Christians show a lot more interest in dialogue with Buddhists than Buddhists show in dialogue with Christians. This is especially the case with respect to dialogue regarding each other’s religious thought.1 Sometimes Christians observe this fact with dismay, or with the implication that there is something wrong with the Buddhist side because of this lack of interest. There is a sense among some Christians that Buddhists should be more interested in learning from Christianity on the level of religious thought. I would like to address this idea that Buddhists should be more interested in learning from Christianity on the level of religious thought.First, several people have noted that the place and function of religious thought in Buddhism are rather different than their place and function in Christianity. For example, as Rita Gross has pointed out, some forms of Buddhist meditation have no reference to Buddhist thought at all—especially some Theravada practices such as mindfulness and choiceless awareness—whereas neither she (at least, at that time) nor I can think of any Christian meditation that doesn’t reference God or Jesus.2Again, Rita Gross has stated that for Christians to take at least some Buddhist thoughts and practices seriously, they needn’t give up necessarily any of their own fundamental doctrinal commitments, whereas the reverse is not the case.3 That is, a [End Page 7] Buddhist who wanted to take Christian thought seriously would almost immediately come face-to-face with Christianity’s theism. They likely would be unable to proceed, since accepting theism would require them to forego the whole edifice of Buddhist thought.Here I must demur. It is true that Christianity’s theism and Buddhism’s nontheism give fundamentally different foundations to their respective worldviews. But surely there are some elements of Christian thought and practice that Buddhists could absorb from Christianity without a fundamental reorientation. Some examples of ideas in Christianity that seem unthreatening to the foundations of Buddhism, yet potentially growth-inspiring for Buddhism in dialogue, come readily to mind. For example, as the relative place of laypeople shifts within modernizing Buddhism, a great deal might be learned from Christian thought on church and community. Again, Christian thought that contemplates realization of the Kingdom of God here and now might be of interest to those Taiwanese Buddhists who speak of a “Pure Land on Earth.” Even in the (semi-)ontological area, Christian thought on Spirit or pneuma might make for a potentially enriching dialogical partner for Buddhists, with their ideas on Buddha nature, Tathagatagarbha and Dharmakaya. The two sets of thinking on Natural Law could be a place of mutual learning. And many of the parables of Jesus have the power to cause people to see things in a new way, regardless of world-view. There is much that Buddhists could absorb from Christians while maintaining their basic worldview. Yet it remains true that it is hard to see much evidence of Buddhists absorbing anything substantial from Christian religious thought.I think that at this point in the Buddhist-Christian dialogue, we can say that the Buddhists have voted with their feet. Buddhist dialoguers are not ignorant of Christian religious thought. There have been some rather deep Buddhist studies, for example, of Jesus and of Christian mystics.4 However, it seems clear that they haven’t, as a rule, found anything there that has... (shrink)

Three‐dimensional (3D) structures have been used to explore the evolution of proteins for decades, yet they have rarely been utilized to study the molecular evolution of peptides. Here, we highlight areas in which 3D structures can be particularly useful for studying the molecular evolution of peptide toxins. Although we focus our discussion on animal toxins, including one of the most widespread disulfide‐rich peptide folds known, the inhibitor cystine knot, our conclusions should be widely applicable to studies of the evolution of (...) disulfide‐constrained peptides. We show that conserved 3D folds can be used to identify evolutionary links and test hypotheses regarding the evolutionary origin of peptides with extremely low sequence identity; construct accurate multiple sequence alignments; and better understand the evolutionary forces that drive the molecular evolution of peptides.Also watch the video abstract. (shrink)