On September 27, 2016 people across the world looked down at their buzzing phones to see the AP Alert: “Baby born with DNA from 3 people, first from new technique.” It was an announcement met with confusion by many, but one that polarized the scientific community almost instantly. Some celebrated the birth as an advancement that could help women with a family history of mitochondrial diseases prevent the transmission of the disease to future generations; others held it unethical, citing medical (...) tourism and consequences for the future of the therapy. The child in question was actually born a few months earlier on April 6, 2016, but the research was published a few months later in the October edition of Fertility and Sterility. The mother carries DNA that could have given the baby Leigh Syndrome, a severe neurological disorder characterized by psychomotor regression that typically results in death between ages two and three.[1] Also known as subacute necrotizing encephalomyelopathy, Leigh Syndrome is caused by genetic mutations in mitochondrial DNA, which causes defective oxidative phosphorylation. Because people with this condition cannot re-form ATP, “demyleniation, gliosis, necrosis, spongiosis, or capillary proliferation”[2] can occur, thereby producing bilateral lesions across the central nervous system. The 36-year-old mother previously had four miscarriages and successfully birthed two children, both of whom survived less than six years due to the syndrome. For religious reasons, the mother opted for Spindle Nuclear Transfer instead of Pronuclear Transfer,[3] which many religious organizations oppose because it entails the destruction of fertilized eggs.[4] In Pronuclear Transfer, both the parent and donor egg are fertilized. The parent’s nuclear material is then removed from the egg containing mutated mitochondria and inserted into the fertilized donor egg—from which the original nuclear material has been removed and destroyed. Spindle Nuclear Transfer, on the other hand, removes the mother’s nuclear material from the egg with unhealthy mitochondria, then implants it into a donor’s egg. The newly created egg is then fertilized with the father’s sperm. This Spindle Nuclear Transfer was performed in Mexico by a team of doctors led by Dr. John Zhang, the founder of the New Hope Fertility Center in New York City. In their report, the doctors outline that five oocytes were successfully reconstituted, four of which developed into blastocysts. Only one was euploid: containing 46 XY chromosomes. Researchers then biopsied that blastocyst and found that the transmission rate of maternal mtDNA was, “5.10 ± 1.11% and the heteroplasmy level for 8993T>G was 5.73%.”[5] This indicates that at the blastocyst stage, around five percent of the mitochondria are from the original maternal egg with the mutation for Leigh Syndrome. After birth, they biopsied different tissues and found that they had an average of less than 1.60 ± 0.92% of transmitted mtDNA from the original maternal egg. The baby is reportedly doing well and the team of doctors concluded that “[h]uman oocytes reconstituted by SNT are capable of producing a healthy live birth. SNT may provide a novel treatment option in minimizing pathogenic mtDNA transmission from mothers to their babies."[6] Even when considered theoretically, Spindle Nuclear Transfer is controversial. Many doctors believe that the risks at this stage of research are too great. Dr. Trevor Stammers, a bioethicist at St. Mary’s University in London, points out: “We do not yet have a clear picture of the interaction between nuclear DNA and mitochondria.”[7] Others hold that faulty mitochondrial DNA can still be transferred during the procedure. Still more argue this technology could create problems because of germline modification.[8] Dr. Paul Knoepfler, a cell biologist at the UC Davis School of Medicine, explains: “Since this is uncharted territory and the children born from this technology would have heritable genetic changes, there are also significant unknown risks to future generations.”[9] However, proponents counter these arguments. They say the benefits outweigh the risks, as “mitochondrial replacement techniques [like Spindle Nuclear Transfer] would eliminate maternal transmission of mitochondrial disease… allowing a woman with a family history of mitochondrial diseases to ensure her children would not be affected.”[10] Additionally, experts say that no symptoms will occur if less than 20% of the transferred mitochondrial DNA is faulty.[11] And while opponents see potential germline modification as a problem, advocates answer that this could stop a family history of mitochondrial disease, which they deem a more serious concern. In this case specifically, however, there are more issues at hand. While the team of doctors did eliminate the possibility of germline modification by selecting a male embryo, there are other ethical concerns. Some argue that this case could be described as “medical tourism.” While New Hope Medical Clinic does maintain a branch in Mexico, Dr. Zhang stated that Mexico has “no rules.”[12] It is a country with underdeveloped regulations, making it difficult to confirm that doctors adhere to widely-held medical and ethical standards. Furthermore, while it is highly unlikely that the child will develop Leigh’s Syndrome, Dr. Dietrich Egli of the New York Stem Cell Foundation says the 5% mitochondrial transfer rate indicates that the technique “was not carried out well.”[13] He points to studies of embryos where the rate of mtDNA transfer was almost ten times lower. Spindle Nuclear Transfer is currently legal in the UK,[14] and many are hoping to see it legalized in the US, although Congress currently prohibits the FDA from considering applications that would entail trials in people.[15] While Dr. Zhang’s work is arguably revolutionary, many wonder if the manner in which this study was performed—in Mexico and with a high mitochondrial transfer rate—will impact the technology’s future in the US. Last week, Dr. Zhang presented the report to scientists gathered in Salt Lake City, saying that while science isn’t a race, it is “in a sense, a race for the family to find a cure, to find hope.”[16] Only time will tell if this study set back other families racing and hoping for a cure. References 1. "Leigh Syndrome." Genetics Home Reference, US National Library of Medicine, 25 Oct. 2016. Accessed 26 Oct. 2016. 2. McKusick, Victor A., and Ada Hamosh. "LEIGH SYNDROME; LS." Online Mendelian Inheritance in Man, Johns Hopkins University, 20 Jan. 2016. Accessed 30 Oct. 2016. 3. Zhang, J, H Liu, S Luo, A Chavez-Badiola, and Z Liu. "First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome." Fertility and Sterility, vol. 106, no. 3, 2016, pp. e375-76. Accessed 30 Oct. 2016. 4. Sample, Ian. "‘Three-parent’ babies explained: what are the concerns and are they justified?" The Guardian, 2 Feb. 2015. Accessed 30 Oct. 2016. 5. Zhang, et al. 6. Ibid. 7. Knapton, Sarah. "Three-parent babies: the arguments for and against." The Telegraph, 3 Feb. 2015. 8. Ibid. 9. Ibid. 10. "Mitochondrial Replacement Therapy FAQs." New York Stem Cell Foundation Research Institute, New York Stem Cell Foundation. Accessed 30 Oct. 2016. 11. Reardon, Sara. "‘Three-parent baby’ claim raises hopes — and ethical concerns." Nature, 28 Sept. 2016. Accessed 30 Oct. 2016. 12. Hamzelou, Jessica. "Exclusive: World’s first baby born with new “3 parent” technique." New Scientist, 27 Sept. 2016. Accessed 30 Oct. 2016. 13. Reardon, Sara. "‘Three-parent baby’ claim raises hopes — and ethical concerns." Nature, 28 Sept. 2016. Accessed 30 Oct. 2016. 14. "3-Person IVF: A Resource Page." Center for Genetics and Society, 24 Oct. 2016. Accessed 30 Oct. 2016. 15. Ritter, Malcolm. "Baby born with DNA from 3 people, first from new technique." Associated Press, 27 Sept. 2016. Accessed 30 Oct. 2016. 16. Chen, Daphne. "Controversy swirls around first three-parent baby." Deseret News, 19 Oct. 2016. Accessed 30 Oct. 2016. Works consulted Swetlitz, Ike. "FDA urged to approve ‘three-parent embryos,’ a new frontier in reproduction." STAT, 3 Feb. 2016. Accessed 30 Oct. 2016. (shrink)

This article had its genesis in the joint paper we gave at the Scholarly Networks and the Emerging Platforms for Humanities Research and Publication Colloquium in April 2015. At that point, we were at the beginning of the Academic Book of the Future Project, which had been funded to run for two years from October 2014 by the UK’s Arts and Humanities Research Council and the British Library. As we write this contribution, the Project has just launched its two (...) final reports, a Project Report by Marilyn Deegan and a Policy Report by Michael Jubb. The Project was conceived of in response to widespread concerns about books, publishing, libraries and the academy. Declining monograph sales, rising serials prices, funding problems, rapidly-changing new technologies, shifting policy landscapes, increasing pressure on academics to do more with less, all contributed to a sense of unease about the health of the academic book in the arts and humanities, and indeed about the health of the disciplines themselves. The Project was run jointly by University College London and King’s College London, with consultancy support from the Research Information Network. It also drew on expertise from across a widespread community coalition of academics, publishers, intermediaries and policy makers. Some hundreds, if not thousands, of individuals have been involved, and many useful deliverables produced. The Project had, and continues to have, considerable impact, and some of its activities, for instance Academic Book Week, will continue for the foreseeable future. (shrink)

Whenever psychologists, neuroscientists, or philosophers draw conclusions about moral judgments in general from a small selected sample, they assume that moral judgments are unified by some common and peculiar feature that enables generalizations and makes morality worthy of study as a unified field. We assess this assumption by considering the six main candidates for a unifying feature: content, phenomenology, force, form, function, and brain mechanisms. We conclude that moral judgment is not unified on any of these levels and that moral (...) science should adopt a more fine-grained taxonomic approach that studies carefully defined groups of moral judgments. (shrink)

Through a series of linked studies, this text provides a wide-ranging analysis of the meeting of two vital themes in the French Revolutionary period.

Drawing on Spinoza’s insights and responding to James’s analysis, I argue that the possibility of a more equal and productive partnership between poetry and philosophy may only be realizable when the resources of each are brought to bear on a common problem external to both. I support this contention by considering how, in Kim Stanley Robinson’s climate fiction novel, The Ministry for the Future, philosophical reasoning about the causes of the current climate crisis is combined with the poetic imagination of (...) a possible climate future for the purposes of motivating readers to put their understanding of what it is rational to do into practice. Finally, I suggest that the formal flexibility of the literary genre grants it a certain privilege over philosophical modes of communication insofar as it allows it to stage the relation between the poetic and the philosophical within its own boundaries. (shrink)

Regular polysemes are sets of ambiguous words that all share the same relationship between their meanings, such as CHICKEN and LOBSTER both referring to an animal or its meat. To probe how a distributional semantic model, here exemplified by bidirectional encoder representations from transformers (BERT), represents regular polysemy, we analyzed whether its embeddings support answering sense analogy questions similar to “is the mapping between CHICKEN (as an animal) and CHICKEN (as a meat) similar to that which maps between LOBSTER (as (...) an animal) to LOBSTER (as a meat)?” We did so using the LRcos model, which combines a logistic regression classifier of different categories (e.g., animal vs. meat) with a measure of cosine similarity. We found that (a) the model was sensitive to the shared structure within a given regular relationship; (b) the shared structure varies across different regular relationships (e.g., animal/meat vs. location/organization), potentially reflective of a “regularity continuum;” (c) some high-order latent structure is shared across different regular relationships, suggestive of a similar latent structure across different types of relationships; and (d) there is a lack of evidence for the aforementioned effects being explained by meaning overlap. Lastly, we found that both components of the LRcos model made important contributions to accurate responding and that a variation of this method could yield an accuracy boost of 10% in answering sense analogy questions. These findings enrich previous theoretical work on regular polysemy with a computationally explicit theory and methods, and provide evidence for an important organizational principle for the mental lexicon and the broader conceptual knowledge system. (shrink)

We argue that critiques of political process theory are beginning to coalesce into new approach to social movements--a "multi-institutional politics" approach. While the political process model assumes that domination is organized by and around one source of power, the alternative perspective views domination as organized around multiple sources of power, each of which is simultaneously material and symbolic. We examine the conceptions of social movements, politics, actors, goals, and strategies supported by each model, demonstrating that the view of society and (...) power underlying the political process model is too narrow to encompass the diversity of contemporary change efforts. Through empirical examples, we demonstrate that the alternative approach provides powerful analytical tools for the analysis of a wide variety of contemporary change efforts. (shrink)

What is free will? Can it exist in a determined universe? How can we determine who, if anyone, possesses it? Philosophers have been debating these questions for millennia. In recent decades neuroscientists have joined the fray with questions of their own. Which neural mechanisms could enable conscious control of action? What are intentional actions? Do contemporary developments in neuroscience rule out free will or, instead, illuminate how it works? Over the past few years, neuroscientists and philosophers have increasingly come to (...) understand that both fields can make substantive contributions to the free-will debate, so working together is the best path forward to understanding whether, when, and how our choices might be free. We therefore asked leading philosophers and neuroscientists which questions related to free will they would most like the other field to answer. Those experts then voted on the 15 most important questions for each field to answer. This book is a collection of the answers to those questions along with follow-up questions from world experts in the neuroscience and philosophy of free will. These varied perspectives will fascinate, illuminate, and stimulate students from both fields along with anyone who wants to be brought up to date on these profound issues. (shrink)

pt. I. The mystical ambition.--pt. II. Revelation.--pt. III. Religion and morality.

We make the case that scientifically accurate and politically feasible responses to the climate crisis require a complex understanding of human cultural practices of niche construction that moves beyond the adaptive significance of culture. We develop this thesis in two related ways. First, we argue that cumulative cultural practices of niche construction can generate stable equilibria and runaway selection processes that result in long-term existential risks within and across cultural groups. We dub this the back of the invisible hand. Second, (...) we argue that the ability of cultural groups to innovate technological solutions to environmental problems is highly constrained in ways that are exacerbated by sustained intergroup conflict, inequality and by inherently unpredictable cascades in climate change and human migration patterns. After developing these theoretical points about human cultural practices of niche construction in detail, we conclude our discussion with some tentative practical suggestions about the way that cultural evolutionary history can more fruitfully be used in efforts to remit the climate crisis and contribute to sustainable practices of human climate change adaptation. (shrink)

A year ago the documents included in this piece were sent out from three locations to three threads of thinkers. Including a small description of the drift process, the Welcome Letter, Protocol & Guidelines, as well as the Statement of Intent are reproduced here in their entirety. This statement was previously published by continent. in-between a conversation of the drift guest editors in issue 2.3.

The cambridge platonists exemplify the fear that newtonian natural philosophy subverts the status of traditional moral and religious beliefs, Which are strongly supported by the innate idea doctrine since it justifies them independently of the senses and the material universe. Isaac barrow, Friend and teacher of newton, Also employs the doctrine approbatively to support his metaphysics as a science of basic principles that constitute the foundation of natural science. Locke's rejection of the doctrine is analyzed and it is suggested that (...) the platonist's treatment of the active role of the mind in sensation could have been developed in eighteenth century britain if locke's polemic had not been so successful. (shrink)

The human ability to live according to learned, shared rules of behavior requires cortical functions. Is the limbic system also necessary for culture or are its functions opposed to it, requiring cortical inhibition? The sizes of monkey and ape neocortical and major limbic structures scale with brain weight, but the neocortex expands more (has a steeper exponent) than limbic structures. As the human brain evolved it did not deviate from the scaling relationships found in nonhuman anthropoids. This evidence for conservation (...) in scaling supports the idea that limbic functions are necessary for human symbolism and culture. (shrink)

It is argued that it is possible that all properties are categorical, contrary to the arguments of Franklin that there must be dispositionality "all the way down". The tasks for which dispositionality is alleged to be needed can be fulfilled by laws of nature, which are categorical relations between universals.

I examine Alan Moore and Kevin O’Neill’s adaptation of Margaret Cavendish’s Blazing World in the comic series The League of Extraordinary Gentlemen. I interpret philosophical aspects of Cavendish’s fictional landscape, including her vitalist materialism and naturalized talking animals, as they appear in series The League of Extraordinary Gentlemen, rendered through 3-D images and corresponding 3-D glasses worn by readers. Through this world adaptation, Moore and O’Neill onboard themes of naturalness, experimentation, technology-aided perceptual processes, and travel to intersecting worlds to enhance (...) The League of Extraordinary Gentlemen’s commentary on the formative influence of fiction on authors and audiences. (shrink)

When two people need a kidney transplant, but only one kidney is available, we need to decide who gets it. If one of the potential recipients needs the kidney because of their own voluntary behavior, but the other is not at all responsible for needing a kidney, then we need to decide whether this fault should be a consideration in favor of the other patient getting the kidney. While there has been considerable philosophical debate on this issue, there is far (...) less research into the views of the public. To explore opinions on these issues, we first asked survey participants to ascribe or deny responsibility for the risky behavior for kidney disease, and for being deprived of a kidney in cases of drinking alcohol, drug abuse, smoking and unhealthy eating when the patient did or did not stop the risky behavior after being diagnosed with kidney disease. Next, we asked participants who should get the kidney when the patient who engaged in risky behavior did or did not know, or have easy access to, the information that the behavior was risky. We found that participants generally ascribed responsibility on the basis of knowledge but allocated the kidney on the basis of access to information. These findings have important implications for moral theories as well as medical policies. (shrink)

A concatenation of forces surrounded the rise of the photographic to the center of contemporary art practice. During the sixties the author-function was seriously critiqued. Roland Barthes announced the death of the author in 1967, and Michel Foucault answered his own question, what is an author? deconstructively in 1969, replacing what William Wimsatt and Monroe Beardsley had already termed the intentional fallacy with a model of the cultural constructedness of all notions of creative agency. At the same time, notions of (...) automatism generated by psychoanalytic models of mind and dada and surrealist conceptions of artistic and literary practice joined forces with sixties anticanonical, postexpressionist notions of the artwork as the deskilled, mechanical product of a consumerist society whose forces yielded the fantasy of individual will. Meanwhile, also during the sixties, painters such as Andy Warhol and Robert Rauschenberg began to use found photographs very overtly either as part and parcel of the generative process of their work or inside their work along with other kinds of materials. And thus the medium-specific boundaries between the photographic and the painterly, just to take the two, began to crumble for good, though the art-school disciplines and museum departments dedicated to these two media continued to hold sway. (shrink)

Soldiers hold special ethical obligations to prioritise care for those closest to them when dealing with combat casualties. This obligation draws on the unique, personal relationships already established, which soldiers have with their comrades. These relationships arguably overrule the need for impartiality barring only a significant difference in the severity of injuries. The bonds of fraternity deserve moral recognition that is not reflected in current conceptions of battlefield medical care. However, an ethics of care (or care ethics) approach does not (...) reject care for enemies but suggests that extension to them occurs when there is no significant difference in severity to comrades first. It also calls on a different form of care called ethical caring, which as opposed to natural caring requires introspection on behalf of the caregiver. Ethics of care distinguishes treatment of the enemy from emotionally detached positions. Emotional detachment rejects the call to care and denies the development of a relationship, which is a foundational principle of care ethics. (shrink)

The biodiversity crisis should be a key issue within debates on global justice – but to date it has not been. This article aims to provide a stimulus to further engagement. First, it provides a brief introduction to the notion of a biodiversity crisis, and to its origins. Second, it distinguishes our various reasons for caring about the crisis. Third, it shows why the biodiversity crisis raises important – albeit hitherto neglected – issues of global justice. Fourth, it sketches some (...) of the most important questions scholars of global justice should be in a position to engage with, in order to move the debate forwards and help ensure that collective political responses to the crisis are just ones. (shrink)

This article addresses the connection of ethics to risk management, and argues that there are compelling reasons to consider good ethical practice to be an essential part of such risk management. That connection has significant commercial outcomes, which include identifying potential problems, preventing fraud, the preservation of corporate reputation, and the mitigation of court penalties should any transgression arise. Information about the legal position, examples of cases, and arguments about the potential benefits of ethics are canvassed. The orientation of this (...) article is essentially Australian. It is hoped that it may provide some insights of value to other countries. (shrink)

At first glance, legislation intended to shape American adult Iiteracy programs appears egalitarian and hopeful. After a more thorough reading, the legislative objectives are Iimited, culturally biased, and largely unattainable. In order to develop coherent Iiteracy pedagogy, we explore Paulo Freire’s definition of critical thinking. From a critical theory perspective, we argue that a vocational education of learning basic skills is insufficient. Furthermore, we believe that more is needed to help adult learners beconle self-sufficient in a modern, dynamic economy. Critical (...) thinking, as defined by Freire, along with vocational education allows individuaIs to develop their ontological right to become aware of historical and social forces. (shrink)

There is growing interest in developing co-operation between adult literacy researchers and practitioners to further research skills and approaches. Canada’s National Literacy Secretariat has recently initiated a series of policy debates that suggested several possibilities: targeted research grants, research internships for practitioners, practical sabbaticals for researchers, support for networking between literacy researchers and practitioners, and joint seminars and workshops between researchers and practitioners. A common theme throughout these discussions is the need to develop critical thinking about both collaborative research and (...) adult literacy. In this paper we discuss two collaborative initiatives between university-based researchers and adult literacy groups in the provinces of British Columbia and Ontario. Each project was based on the notion of “research circles” and specifically designed to enhance research capacity and critical thinking about literacy research. (shrink)

Most of the New Theory of Vision is an argument for a negative answer to Molyneux's question.// re primacy of vision in spatial perception: "most rational philosopher on this topic is Berkeley, whose New Theory of Vision presents in cogent detail the argument" (from Bennett 1966, p. 30, in note cites 41ff.).// Berkeley's criticisms of Locke: "If we really abstract from colour and hardness and all that 'belongs to sensation', so far from being left with 'pure' notions of extension and (...) figure, we are left with nothing but words emptied of meaning" (from Strawson 1966, p. 61). (shrink)