Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...) or religious grounds. This article deals with four different types of case constellations that result from these possible reasons against PGD as well as from the necessity or dispensability of a subsequent “control PGD.” These cases are discussed based on hypotheses concerning contextual factors and theoretical assumptions. In conclusion, we point out that if our assumptions are correct, there is probably no therapeutic imperative for genome editing at the germline level. We draw this rationale from the fact that germline interventions are likely not person-affecting. However, we caution the reader that our result is preliminary and needs to be more carefully examined in future work in light of the bioethical debate and potential objections. -/- // Abstract: Im Zentrum dieses Working Papers steht die Frage, ob es einen therapeutischen Imperativ geben kann, der uns, in bestimmten Situationen, verpflichten würde, eine Genomeditierung (genome editing) auf Keimbahnebene im Rahmen der assistierten Befruchtung vorzunehmen. Die Antwort auf diese zentrale Frage wird insbesondere mit Bezug auf Fälle diskutiert, in denen das Verfahren der Präimplantationsdiagnostik (PID) keine aus entweder medizinischen oder ethischen oder – aus Sicht der potentiellen Eltern – moralischen bzw. religiösen Gründen akzeptable Alternative zu einem Keimbahneingriff darstellt. Die möglichen Gründe gegen die PID sowie die Erforderlichkeit oder Verzichtbarkeit einer nachfolgenden «Kontroll-PID» ergeben vier verschiedene Fallkonstellationen, denen sich der Beitrag zuwendet. Auf Grundlage von Hypothesen zu kontextuellen Faktoren und theoretischen Annahmen diskutieren wir diese Fälle. Im Ergebnis verweisen wir darauf, dass es, wenn unsere Annahmen zutreffen, vermutlich keinen therapeutischen Imperativ zum genome editing auf Keimbahnebene gibt. Dies begründet sich daraus, dass der Keimbahneingriff vermutlich nicht als personenbezogen (person-affecting) zu bezeichnen ist. Wir weisen jedoch darauf hin, dass unser Ergebnis vorläufig ist und unter Berücksichtigung der bioethischen Debatte und möglicher Einwände genauer geprüft werden muss. -/- // Résumé: Ce Working Paper se concentre sur la question de l’existence d’un impératif thérapeutique qui, dans des situations spécifiques, nous obligerait à réaliser une édition du génome au niveau de la lignée germinale dans le cadre de la procréation assistée. Afin de répondre à cette question centrale nous développons quatre scénarios spécifiques dans lesquels le diagnostic préimplantatoire (DPI) ne représente pas une alternative acceptable à l’édition du génome germinal pour des raisons médicales, éthiques ou – du point de vue des futurs parents – morales ou religieuses. Cet article traite de quatre constellations différentes de cas résultant des raisons mises en avant pour s'opposer au DPI ainsi que de la nécessité ou de l’inutilité d’un ultérieur « DPI de contrôle » Ces cas sont discutés sur la base d’hypothèses portant sur les facteurs contextuels et sur les présupposés théoriques. En conclusion, nous soulignons que si nos hypothèses sont correctes, il n’y a probablement aucun impératif thérapeutique justifiant l’édition du génome au niveau de la lignée germinale. Nous arrivons à cette conclusion parce qu’une intervention au niveau de la lignée germinale n’est probablement pas susceptible d’affecter la personne. Cependant, nous mettons en garde le lecteur sur le fait que notre conclusion est préliminaire et qu’elle doit être examinée avec soin dans des futurs travaux instruits par le débat bioéthique et par les éventuelles objections. (shrink)

The foundations of research ethics are riven with fault lines emanating from a fear that if research is too closely connected to weighty social purposes an imperative to advance the common good through research will justify abrogating the rights and welfare of study participants. The result is an impoverished conception of the nature of research, an incomplete focus on actors who bear important moral responsibilities, and a system of ethics and oversight highly attuned to the dangers of research but largely (...) silent about threats of ineffective, inefficient, and inequitable medical practices and health systems. -/- In For the Common Good: Philosophical Foundations of Research Ethics, Alex John London defends a conception of the common good that grounds a moral imperative with two requirements. The first is to promote research that generates the information necessary to enable key social institutions to effectively, efficiently, and equitably safeguard the basic interests of individuals. The second is to ensure that research is organized as a voluntary scheme of social cooperation that respects its various contributors' moral claims to be treated as free and equal. Connecting research to the goals of a just social order grounds a framework for assessing and managing research risk that reconciles these requirements and justifies key oversight practices in non-paternalistic terms. Reconceiving research ethics as resolving coordination problems and providing credible assurance that these requirements are being met expands the issues and actors that fall within the purview of the field and provides the foundation for a more unified and coherent approach to domestic and international research. -/- This is an open access title available under the terms of a CC BY-NC-ND 4.0 license. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. (shrink)

ABSTRACTMany discussions of the ‘preface paradox’ assume that it is more troubling for deductive closure constraints on rational belief if outright belief is reducible to credence. I show that this is an error: we can generate the problem without assuming such reducibility. All that we need are some very weak normative assumptions about rational relationships between belief and credence. The only view that escapes my way of formulating the problem for the deductive closure constraint is in fact itself a reductive (...) view: namely, the view that outright belief is credence 1. However, I argue that this view is unsustainable. Moreover, my version of the problem turns on no particular theory of evidence or evidential probability, and so cannot be avoided by adopting some revisionary such theory. In sum, deductive closure is in more serious, and more general, trouble than some have thought. (shrink)

This paper offers a new account of how structural rationality, or coherence, is normative. The central challenge to the normativity of coherence – which I term the problem of “making space” for the normativity of coherence – is this: if considerations of coherence matter normatively, it is not clear how we ought to take account of them in our deliberation. Coherence considerations don’t seem to show up in reasoning about what to believe, intend, desire, hope, fear, and so on; moreover, (...) they seem awkward to take account of alongside more “substantive” considerations about the merits of such attitudes. I aim here to solve this problem, and in so doing to offer the aforementioned new account of how coherence is normative. On the view I defend, which I call the Reasons-to-Structure-Deliberation model, considerations of coherence constitute reasons for structuring deliberation in certain ways: more particularly, to treat incoherent combinations of attitudes as off-limits, and so to focus one’s deliberation on choosing between the coherent combinations. (shrink)

Suppose that you must make choices that may influence the well-being and the identities of the people who will exist, though not the number of people who will exist. How ought you to choose? This paper answers this question. It argues that the currency of distributive ethics in such cases is a combination of an individual’s final well-being and her expected well-being conditional on her existence. It also argues that this currency should be distributed in an egalitarian, rather than a (...) prioritarian, manner. (shrink)

That biology provides explanations is not open to doubt. But how it does so must be a vexed question for those who deny that biology embodies laws or other generalizations with the sort of explanatory force that the philosophy of science recognizes. The most common response to this problem has involved redefining law so that those grammatically general statements which biologists invoke in explanations can be counted as laws. But this terminological innovation cannot identify the source of biology's explanatory power. (...) I argue that because biological science is historical, the problem of biological explanation can be assimilated to the parallel problem in the philosophy of history, and that the problem was solved by Carl Hempel. All we need to do is recognize that the only laws that biology—in all its compartments from the molecular onward—has or needs are the laws of natural selection. (shrink)

We challenge Bruineberg et al's view that Markov blankets are illicitly reified when used to describe organismic boundaries. We do this both on general methodological grounds, where we appeal to a form of structural realism derived from Bayesian cognitive science to dissolve the problem, and by rebutting specific arguments in the target article.

Does lying require a speaker to explicitly express something (she believes to be) false, or is it also possible to lie with deceptive implicatures? Given that consistency with ordinary language is a desideratum of any philosophical definition of lying, several studies have addressed this question empirically in recent years. Their findings, however, seem to be in conflict. This paper reports an experiment with 222 participants that investigates the hypothesis that these conflicting results are due to variation regarding whether or not (...) the speaker’s intention to deceive and the implicated content are made explicit. It is found that the presence versus the absence of such explicitness has a strong impact on people’s lie judgements, and can thus account for the conflicting results in the literature. (shrink)

I note the multitude of ways in which, beginning with the classic paper by Machamer et al., the mechanists have qualify their methodological dicta, and limit the vulnerability of their claims by strategic vagueness regarding their application. I go on to generalize a version of the mechanist requirement on explanations due to Craver and Kaplan :601–627, 2011) in cognitive and systems neuroscience so that it applies broadly across the life sciences in accordance with the view elaborated by Craver and Darden (...) in In Search of Mechanisms. I then go on to explore what ramifications their mechanist requirement on explanations may have for explanatory “dependencies” reported in biology and the special sciences. What this exploration suggests is that mechanism threatens to eliminate instead of underwrite a large number of such “dependencies” reported in higher-levels of biology and the special sciences. I diagnose the source of this threat in mechanism’s demand that explanations identify nested causal differences makers in mechanisms, their components, the components further components, and so forth. Finally, I identify the “love–hate” relationship mechanism must have with functional explanation, and show how it makes mechanism an extremely interesting thesis indeed. (shrink)

Eliminativism about intentional content argues for its conclusion from the partial correctness of all three of the theses Hutto and Satne seek to combine: neo-Cartesianism is correct to this extent: if there is intentional content it must originally be mental. Neo-Behaviorism is correct to this extent: attribution of intentional content is basically a heuristic device for predicting the behavior of higher vertebrates. Neo-Pragmatism is right to this extent: the illusion of intentionality in language is the source of the illusion of (...) intentionality in thought. Eliminativists employ the insights of all three “neo”-theses to explain why there is no such thing and why the systematic illusion that there is intentional content runs so deep. (shrink)

Reductionism is a metaphysical thesis, a claim about explanations, and a research program. The metaphysical thesis reductionists advance (and antireductionists accept) is that all facts, including all biological facts, are fixed by the physical and chemical facts; there are no non-physical events, states, or processes, and so biological events, states and processes are “nothing but” physical ones. The research program can be framed as a methodological prescription which follows from the claim about explanations. Antireductionism does not dispute reductionism’s metaphysical claim, (...) but rejects the explanatory claim and so the methodological moral. To a first approximation what reductionists and antireductionists disagree about is whether explanations in functional biology can be or need to be explained by or completed or perhaps replaced by explanations in terms of molecular biology.i And this disagreement over the adequacy of explanations in functional biology drives a significant methodological disagreement with consequence for the research program of biology. (shrink)

Stephen Finlay’s book Confusion of Tongues is extraordinarily sophisticated, ambitious and thought-provoking. I highly commend it to those who haven’t read it yet. I will begin this commentary with a summary of which big-picture issues Finlay and I agree on and which we disagree on.

Employing a well-known local regularity from macroeconomics, the Phillips curve, I examine Woodward’s ([2000], [2003]) account of the explanatory power of such historically restricted generalizations and the mathematical models with which they are sometimes associated. The article seeks to show that, pace Woodward, to be explanatory such generalizations need to be underwritten by more fundamental ones, and that rational choice theory would not avail in this case to provide the required underwriting. Examining how such explanatory restricted regularities are underwritten in (...) biology—by unrestricted Darwinian regularities—provides the basis for an argument that Darwinian regularities serve the same function in human affairs. The general argument for this claim requires, inter alia , that we accept some version or other of a theory of memes. The article concludes by clearing the field of some prominent objections to the existence of memes, and extracting some policy implications from the persistence and acceleration of arms races in human affairs. (shrink)

The prevailing discourse around AI ethics lacks the language and formalism necessary to capture the diverse ethical concerns that emerge when AI systems interact with individuals. Drawing on Sen and Nussbaum’s capability approach, we present a framework formalizing a network of ethical concepts and entitlements necessary for AI systems to confer meaningful benefit or assistance to stakeholders. Such systems enhance stakeholders’ ability to advance their life plans and well-being while upholding their fundamental rights. We characterize two necessary conditions for morally (...) permissible interactions between AI systems and those impacted by their functioning, and two sufficient conditions for realizing the ideal of meaningful benefit. We then contrast this ideal with several salient failure modes, namely, forms of social interactions that constitute unjustified paternalism, coercion, deception, exploitation and domination. The proliferation of incidents involving AI in high-stakes domains underscores the gravity of these issues and the imperative to take an ethics-led approach to AI systems from their inception. (shrink)

Indifferent lies have been proposed as a counterexample to the claim that lying requires an intention to deceive. In indifferent lies, the speaker says something she believes to be false (in a trut...

While Marx’s animating spirit can be found at the heart of much work in critical discourse studies, use of his ideas and concepts in this work is much less widespread. This has, however, been slowl...

Before participants can be enrolled in a clinical trial, an institutional review board must determine that the risks that the research poses to participants are ‘reasonable.’ This paper examines the two dominant frameworks for assessing research risks and argues that each approach suffers from significant shortcomings. It then considers what issues must be addressed in order to construct a framework for risk assessment that is grounded in a compelling normative foundation and might provide more operationally precise guidance to the deliberations (...) of various stakeholders. The paper concludes by sketching the outlines of what is referred to as the ‘Integrative Approach’ to risk assessment and by highlighting some of the ways in which this approach may be more promising than current alternatives. (shrink)

LLMs are statistical models of language learning through stochastic gradient descent with a next token prediction objective. Prompting a popular view among AI modelers: LLMs are just next token predictors. While LLMs are engineered using next token prediction, and trained based on their success at this task, our view is that a reduction to just next token predictor sells LLMs short. Moreover, there are important explanations of LLM behavior and capabilities that are lost when we engage in this kind of (...) reduction. In order to draw this out, we will make an analogy with a once prominent research program in biology explaining evolution and development from the genes eye view. (shrink)

A. G. Long presents a new account of the importance of conversation in Plato's philosophy.

Education has two distinct but interconnected layers. There is an outer layer concerned with knowledge transfer and skills and an inner layer concerned with the development of character and relationships with others, both individually and socially. This inner layer provides the individual with the capacity to influence and to change society. In that sense, such an inner layer is ‘political’. In this article we argue that the ‘political’ in education can take two distinct forms: either that of dialogue or of (...) defiance. We claim that the former is epitomised by the philosophy of Martin Buber and the latter by the philosophy of Frantz Fanon. Our analysis contrasting these two philosophies clarifies the implications for education, and thereby for the individual and for society. (shrink)

The study of economics has been a going concern among philosophers for the better part of twenty years without very many people even noticing that economics has a metaphysics. Indeed, among economists the term ‘metaphysical’ is probably an epithet of opprobrium, employed to suggest that a claim is untestable or otherwise without cognitive significance. Philosophers of economics will admit to the existence of an epistemology of economics—the study of the nature, extent and justification of economic knowledge. But even this is (...) controversial among some economists. The notion that economics might have a metaphysics as well as an epistemology will be scoffed at by those economists doubtful about the enterprise of the philosophy of economics altogether. Nevertheless, philosophers of economics should have no trouble identifying a metaphysics in some of the theoretical commitments of economics. (shrink)

I argue that Scanlon's Value of Choice View does not offer a plausible account of substantive responsibility. I offer a new account, which I call the Potential Value of Opportunities View. On this view, when a person is in a position to freely and capably make an informed choice, we assess her situation not by the outcome she achieves but by the potential value of her opportunities. This value depends on the value of the various things that she can achieve (...) through her choices, as well as on how disposed she is to choose her better options and avoid her worse options. This view explains the priority we give to preventing harm that a person cannot avoid by choosing appropriately over harm that a person can so avoid by the fact that the second person has a valuable opportunity that the first does not have. It explains the importance of protecting people against choosing badly by the value of being placed in circumstances in which one is disposed to choose well, and the disvalue of being exposed to the danger of coming to harm by choosing badly. (shrink)

In contemporary Cognitive Science and Philosophy of Mind, "attention" is a burgeoning field, with ever-increasing amounts of empirical research and philosophical analysis being directed toward it.1 In this essay I make a first attempt to contrast how Nyāya-Vaiśeṣikas2 and Buddhists would address some aspects of attention that are discussed in that literature. The sources of what I attribute to "Nyāya-Vaiśeṣikas" are the sections dealing with the manas in the Nyāyabhāṣya, Nyāyamañjarī, and Praśastapādabhāṣya. The words "Buddhist" and "Buddhism" in this essay (...) refer specifically to the Sautrāntika Buddhism of Vasubandhu's Abhidharmako-śabhāṣya.3 A comparison... (shrink)

In “Mind, matter and metabolism,” Godfrey-Smith’s objective is to “develop a picture” in which, first, the basis of living activity in physical processes “makes sense,” second, the basis of proto-cognitive activity in living activity “makes sense” and third, “the basis of subjective experience in metabolically situated cognitive processes also makes sense.” show that he fails to attain all three of these objectives, largely owing to the nature and modularization of metabolism.

: An Aristotelian conception of practical ethics can be derived from the account of practical reasoning that Aristotle articulates in his Rhetoric and this has important implications for the way we understand the nature and limits of practical ethics. An important feature of this conception of practical ethics is its responsiveness to the complex ways in which agents form and maintain moral commitments, and this has important implications for the debate concerning methods of ethics in applied ethics. In particular, this (...) feature enables us to understand casuistry, narrative, and principlism as mutually supportive modes of moral inquiry, rather than divergent and mutually exclusive methods of ethics. As a result, an Aristotelian conception of practical ethics clears the conceptual common ground upon which practical ethicists can forge a stable and realistic self-understanding. (shrink)

The Problem of Suffering (PoS) claims that there is a tension between the existence of a perfect God and suffering. The Problem of Hell (PoH) is a version of PoS which claims that a perfect God would lack morally sufficient reasons to allow individuals to be eternally damned to Hell. A few traditional solutions have been developed to PoH, but each of them is problematic. As such, if there is a solu­tion to PoH that is resistant to these problems, then (...) it deserves our attention. In this paper, I develop precisely such a solution. I call this the Unpopulated Hell View (UHV), which claims that Hell exists as a place where eternal damnation could take place, although it never does. First, I explain how UHV solves PoH. Next, I develop four objections against UHV and defend UHV against them. I argue that, although some of these objections do more damage to UHV than others, UHV has satisfying responses to all of them. Ultimately, I conclude that UHV merits consideration as a novel solution to PoH because it is less problematic than the traditional ones. (shrink)

An interview with Philippa Foot about her book 'Natural Goodness' and the development of her thought. (Note: A slightly revised version appears in Conversations on Ethics, OUP 2009).

This article offers a new reading of the Muse in Empedocles’ Physica. I aim to show that she is integrated into the poet’s physiological conception of the cosmos and that she also plays a central role in the furtherance of his eschatological purposes. Empedocles, it will be suggested, first put the Muse at the service of the philosophical logos, and in taking that step, he embraced and transcended the conventions of Muse-invocation not only in epic-didactic poetry but in the lyric (...) and elegiac traditions as well. On this reading, the “Muse of the agathos logos ” will emerge as a strikingly innovative creation, one that was to exercise a powerful and enduring influence on Greek and Roman conceptions of the goddess Muse in relation to the mind of the poet. (shrink)

Genocentrism, the thesis that the genes play a special role in the causation of development is often rejected in favor of a 'causal democracy thesis' to the effect that all causally necessary conditions for development are equal. Genocentrists argue that genes play a distinct causal role owing to their informational content and that this content enables them to program the embryo. I show that the special causal role of the genome hinges not on its informational status — it has none, (...) or at least no more than computer programs have independent of our interpretations of them — but on its power literally to program the embryo, a power nicely illustrated in the use of polynucleotide sequences to compute solutions to NP hard problems in mathematics. (shrink)

This paper considers whether the available evidence from archeology, biological anthropology, primatology, and comparative gene-sequencing, can test evolutionary game theory models of cooperation as historical hypotheses about the actual course of human prehistory. The examination proceeds on the assumption that cooperation is the product of cultural selection and is not a genetically encoded trait. Nevertheless, we conclude that gene sequence data may yet shed signi cant light on the evolution of cooperation.

This article proposes building on the success of publicly funded drug research and development and expanding the model to include the full cycle development, testing, manufacture and distribution of innovative and affordable new drugs.

Nossa proposta neste ensaio é descrever a primeira problematização apresentada por Merleau-Ponty a respeito da noção de Natureza em seus cursos ministrados no Collège de France,defendendo a hipótese de que ele a constrói, em grande medida, através de um diálogo e de umainterpretação particular do pensamento cartesiano. Procuraremos mostrar que Merleau-Pontyreconhece em Descartes a permanência de uma ontologia implícita ou latente – coexistente com suaontologia “oficial” –, que “resiste” à formulação puramente inteligível da ideia de Natureza, e que,por isso mesmo, (...) preserva para ela o campo da existência e da realidade. (shrink)

Resumo Este artigo defende o ponto de vista de que as bases da ciência cognitiva contemporânea estão em sintonia com o pensamento de Merleau-Ponty, em seus aspectos antiobjetivista e antirrepresentacionalista. A ideia de representação mental é contestada, tanto na CC quanto no pensamento de Merleau-Ponty. A cognição não espelha um mundo exterior independente dos sujeitos incorporados. O mundo é um existencial, como afirmam Merleau-Ponty e a CC. A hipótese da representação mental supõe que o mundo pode ser percebido de forma (...) independente do sujeito que percebe. Isso não é verdade. A percepção depende da forma como o sujeito age em seu mundo percebido. Todas as estimulações que o organismo encontra só são possíveis pelos seus movimentos precedentes que resultam na exposição do órgão receptor às influências externas. Os estímulos sensoriais que o organismo encontra dependem diretamente do seu comportamento motor e a forma como o organismo se move depende diretamente das consequências sensoriais dos seus comportamentos anteriores.This article defends the view that the foundations of contemporary cognitive science are in tune with Merleau-Ponty’s thinking in its anti-objectivist and anti-representationalist aspects. The idea of mental representation is contested both in CC and in Merleau-Ponty’s thinking. Cognition does not mirror an outside world independent of embodied subjects. The world is an existential one as Merleau-Ponty and the CC say. The mental representation hypothesis assumes that the world can be perceived independently of the perceiving subject. This is not true. Perception depends on how the subject acts in his perceived world. All the stimulations that the organism finds are only possible by its previous movements that result in the exposure of the receiving organ to external influences. The sensory stimuli that the organism finds depend directly on its motor behavior and the way the organism moves depends directly on the sensory consequences of its previous behaviors. (shrink)

Este texto procura circunscrever alguns traços de um tipo de racionalidade formal, que encontra no cinismo uma de suas expressões privilegiadas. Buscamos delimitar algumas características do modo de operação dessa razão, sobretudo enquanto negatividade ou recusa da significação própria ao seu objeto e, no limite, ao mundo. Nessa direção, tentamos, ainda, apontar alguns limites para esse projeto de formalização total e de negação completa do mundo enquanto tal.

Microeconomic theory and the theory of natural selection share salient features. This has encouraged economics to appeal to the character of evolutionary theory in defending the adequacy of microeconomics, despite its evident weaknesses as an explanatory or predictive theory. This paper explores the differences and similarities between these two theories and the phenomena they treat in order to assess the force of the economist's appeal to evolutionary theory as a model for how economic theory should proceed.

The paper argues that substantial support for Soros' claims about uncertainty and reflexivity in economics and human affairs generally are provided by the operation of both factors in the biological domain to produce substantially the same processes which have been recognized by ecologists and evolutionary biologists. In particular predator prey relations have their sources in uncertainty – i.e. the random character of variations, and frequency dependent co-evolution – reflexivity. The paper argues that despite Soros' claims, intentionality is not required to (...) produce these phenomena, and that where it does so, in the human case, it provides no basis to deny a reasonable thesis of the methodological or causal unity of science. The argument for this conclusion is developed by starting with a biological predator/prey relation and successively introducing intentional components without affecting the nature of the process. Accepting the conclusion of this argument provides substantial additional inductive support for Soros' theory in its economic application. (shrink)