Cells utilize diverse organelles to maintain homeostasis and to respond to extracellular stimuli. Recently, multifaceted aspects of organelle stress caused by various factors have been emerging. The endosome is an essential organelle, functioning as the central hub for membrane trafficking in cooperation with the ubiquitin system. However, knowledge regarding endosomal stress, which refers to organelle stress of the endosome, is currently limited. We recently revealed ubiquitin‐mediated endosomal stress of early endosomes (EEs) and its responsive signaling pathways. These findings shed light (...) on the relevance of ubiquitin‐mediated endosomal stress to physiological and pathological processes. Here, we present a hypothesis that ubiquitin‐mediated endosomal stress may have significant roles in biological contexts and that ubiquitin‐specific protease 8 is a key regulator of ubiquitin clearance from EEs. (shrink)

The aim of this paper is to demonstrate what Descartes’ purpose of philosophy is by raising questions concerning the style of Descartes’ writing. In particular, I shall focus on investigating the characteristic style of Descartes’ Discourse on the Method. It is often considered that Descartes is not only the founder of modernphilosophy but also the father of foundationalism in epistemology. In fact, Descartes’ most celebrated argument of cogito is sometimes understood only in the context of epistemological foundationalism. However, Descartes’ epistemology (...) is quite different from the one that is often understood as the theory of knowledge in the contemporary scene of philosophy. Paying attention to Descartes’ style of writing, we realize that it is necessary for us to see his epistemology in a different framework from the contemporary philosophers’. I shall show that the purpose of philosophy for Descartes is not to present disputations for propounding anddefending his own theory in philosophy, but to let the readers of his writing engaged with philosophy. (shrink)

Sound-symbolism is the nonarbitrary link between the sound and meaning of a word. Japanese-speaking children performed better in a verb generalization task when they were taught novel sound-symbolic verbs, created based on existing Japanese sound-symbolic words, than novel nonsound-symbolic verbs (Imai, Kita, Nagumo, & Okada, 2008). A question remained as to whether the Japanese children had picked up regularities in the Japanese sound-symbolic lexicon or were sensitive to universal sound-symbolism. The present study aimed to provide support for the latter. (...) In a verb generalization task, English-speaking 3-year-olds were taught novel sound-symbolic verbs, created based on Japanese sound-symbolism, or novel nonsound-symbolic verbs. English-speaking children performed better with the sound-symbolic verbs, just like Japanese-speaking children. We concluded that children are sensitive to universal sound-symbolism and can utilize it in word learning and generalization, regardless of their native language. (shrink)

In German, nouns are assigned to one of the three gender classes. For most animal names, however, the assignment is independent of the referent’s biological sex. We examined whether German-speaking children understand this independence of grammar from semantics or whether they assume that grammatical gender is mapped onto biological sex when drawing inferences about sex-specific biological properties of animals. Two cross-linguistic studies comparing German-speaking and Japanese-speaking preschoolers were conducted. The results suggest that German-speaking children utilize grammatical gender as a cue (...) for inferences about sex-specific properties of animals. Further, we found that Japanese- and German-speaking children recruit different resources when drawing inferences about sex-specific properties: Whereas Japanese children paralleled their pattern of inference about properties common to all animals, German children relied on the grammatical gender class of the animal. Implications of these findings for studying the relation between language and thought are discussed. (shrink)

Objects and substances bear fundamentally different ontologies. In this article, we examine the relations between language, the ontological distinction with respect to individuation, and the world. Specifically, in cross‐linguistic developmental studies that follow Imai and Gentner (1997), we examine the question of whether language influences our thought in different forms, like (1) whether the language‐specific construal of entities found in a word extension context (Imai & Gentner, 1997) is also found in a nonlinguistic classification context; (2) whether the (...) presence of labels per se, independent of the count‐mass syntax, fosters ontology‐based classification; (3) in what way, if at all, the count‐mass syntax that accompanies a label changes English speakers' default construal of a given entity?On the basis of the results, we argue that the ontological distinction concerning individuation is universally shared and functions as a constraint on early learning of words. At the same time, language influences one's construal of entities cross‐lingistically and developmentally, and causes a temporary change of construal within a single language. We provide a detailed discussion of how each of these three ways language may affect the construal of entities, and discuss how our universally possessed knowledge interacts with language both within a single language and in cross‐linguistic context. (shrink)

Grammatical gender is independent of biological sex for the majority of animal names (e.g., any giraffe, be it male or female, is grammatically treated as feminine). However, there is apparent semantic motivation for grammatical gender classes, especially in mapping human terms to gender. This research investigated whether this motivation affects deductive inference in native German speakers. We compared German with Japanese speakers (a language without grammatical gender) when making inferences about sex-specific biological properties. We found that German speakers tended to (...) erroneously draw inferences when the sex in the premise and grammatical gender of the target animal agreed. An over-generalization of the grammar–semantics mapping was found even when the sex of the target was explicitly indicated. However, these effects occurred only when gender-marking articles accompanied the nouns. These results suggest that German speakers project sex-specific biological properties onto gender-marking articles but not onto conceptual representations of animals per se. (shrink)

November 4th-5th, 2012 at Kyoto University. Organizers: Hisashi Nakao & Pierre-Alain Braillard.

Although Caenorhabditis and Drosophila proved invaluable in unraveling the molecular mechanisms of apoptosis, it is now clear that these animals are of limited value for understanding the evolution of apoptotic systems. Whereas data from these invertebrates led to the assumption that the extrinsic apoptotic pathway is restricted to vertebrates, recent data from cnidarians and sponges indicate that this pathway predates bilaterian origins. Here we review the phylogenetic distribution of caspase‐8, the initiator caspase of the extrinsic apoptotic pathway, its paralogs and (...) other components of the network. The ancestral caspase‐8 gave rise to four paralogs early in vertebrate evolution, and these have been maintained in many tetrapods. However, eutherians have lost caspase‐18 and myomorph rodents have lost caspase‐10, these losses suggesting functional redundancy amongst caspase‐8 paralogs. The apoptotic network of the eumetazoan ancestor appears to have been complex and vertebrate like, and is only now being revealed by studying simple animals. (shrink)

Die Naturalistische Auffassung der Pädagogik scheint unaufhaltsam voranzuschreiten, wie es an der globalen Tendenzen der „learnification“ der Erziehung ablesbar ist. Naturalistische Ansätze hinterlassen in der Pädagogik sichtlich widersprüchliche Konsequenzen: die Hervorhebung der vorbestimmten und der plastischen Merkmale der menschlichen Natur und ferner die Hervorhebung der aktiven und der rezeptiven Seiten der menschlichen Plastizität. Um die komplizierte Beziehungsstruktur dieser doppelten Beidseitigkeit zu erläutern, wird auf die geschichtliche Ursprungsphase der pädagogischen Auseinandersetzungen mit dem Naturalismus zurückgegriffen: eine Auseinandersetzung mit der Evolutionstheorie in der (...) Pädagogik in der zweiten Hälfte des 19. und am Anfang des 20. Jahrhunderts. (shrink)

In Japan during the 1980s, there was an interesting debate about how to teach the area of a parallelogram effectively to primary school children. Yutaka Saeki criticized the standard method, which relies on a cut-and-paste procedure. He argued that the standard method inevitably failed to convince children because it does not provide any cogent reason for them to accept that the formula ‘base x height’ is indeed true. Saeki proposed his own method using a bundle of paper. This method, however (...) convincing at first glance, was totally dismissed by Akira Nakagaki based on his orthodox scientific methodology. There emerged a lively debate between the two. By means of a reconstruction of this debate, this paper will show how the materiality of a thing can scaffold the process of gaining understanding of the concept of geometrical space. Although Saeki and Nakagaki were both unaware of the fact, the debate between them shows clearly that the convincing points of Saeki’s method rely on its material basis. The materiality of a thing can serve as a common basis, in which acquaintance in the context of everyday life is transgressed to the mathematical context. With this transgressive structure entailed in the materiality of a thing, children can be led to understand the spatial logic of the parallelogram, while they themselves make their own reasoning and judgement based on the context of their everyday lives. (shrink)

This paper compares aspects of the thinking of Walter Benjamin and John Dewey. Both attempted to address the problem of ‘poverty of experience’ in modern society by means of an anti-dualistic concept of experience and the concept of media. These concepts can be observed optimally in their work on aesthetics. Such concepts of experience and media were the keys to the development of new conceptions of education. Differences in their understanding of media, however, led them to different strategies in the (...) development of their educational thought. The present paper will show that Benjamin's strategy offers a promising alternative to that of Dewey. (shrink)