While the governance of human existence is organised ever-increasingly around life and its potential to proliferate beyond all limits, much critical reflection on the phenomenon is underpinned by considerations about the very negation of life, death. The challenge is to construct an alternative understanding of human existence that is truer to the complexity of the present, biopolitical moment. Palladino responds to the challenge by drawing upon philosophical, historical and sociological modes of inquiry to examine key developments in the history of (...) biomedical understanding of ageing and death. He combines this genealogy with close reflection upon its implications for a critical and effective reading of Foucault's and Deleuze's foundational work on the relationship between life, death and embodied existence. Biopolitics and the Philosophy of Death proposes that the central task of contemporary critical thought is to find ways of coordinating different ways of thinking about molecules, populations and the mortality of the human organism without transforming the notion of life itself into the new transcendent truth that would take the place once occupied by God and Man. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.3 (2002) 465-481 [Access article in PDF] The Physiology of Political Economy: Vitalism and Adam Smith's Wealth of Nations Catherine Packham The Scottish Enlightenment has been described as uniting a concern with the origins and foundations of knowledge with a preoccupation with the useful application of knowledge in schemes of practical improvement. 1 Adam Smith's Inquiry into the Nature and Causes of the (...) Wealth of Nations, which combines a theoretical account of political economy with specific proposals on politico-economic matters, might seem to exemplify such a characterization. For some commentators at the time of its publication, however, Smith's lack of practical experience in the field of trade disqualified any claims he might make to authoritative knowledge. Sir John Pringle, for instance, military surgeon and friend of Smith's, thought that a man "who had never been in trade could not be expected to write well on the subject"; and while Dr. Johnson repudiated this, suggesting that all that was necessary was "extensive views," Pringle's opinion was not unusual. 2 Such objections, interrogating the very basis of Smith's expertise, reiterate, in the context of his work, the same kinds of questions regarding knowledge's provenance which preoccupied his age, and which were indeed addressed by Smith himself. Smith's own account of the formation of philosophical knowledge rests not on the authority of experience but on the role of the imagination; he understood systematic knowledge as an imaginative "machine" or work of fancy created to please and soothe a mind disturbed by phenomena which are observed but unexplained. 3 Smith's account of philosophical [End Page 465] knowledge, in which he would include his own Wealth of Nations, suggests that his own expertise should be judged not on the extent of his personal experience of the matters discussed but on the explanatory power and pleasurable nature of the system which he outlines. With its emphasis on the work of the philosophical imagination, his account also suggests that some of the sources for that system might be somewhat unexpected, a suggestion which this paper will pursue.Such questions concerning the genesis and formation of the new discourse of political economy instituted by Wealth of Nations have recurred in our own time, informing some of the more illuminating of recent work on Smith. Rejecting a tradition which assesses the significance of Wealth of Nations in terms of its anticipation of modern economic analysis, revisionist historians of political and economic thought have, since the late 1970s, offered more contextualist accounts of the work, tracing the relations between Smith's moral and economic philosophy and the contemporary discourses of natural jurisprudence and civic humanism. Other commentators have borrowed from literary scholarship to examine the textual and discursive conventions through which Smith's writings construct and sustain their meanings. 4 Such work has given a new emphasis to the textual and discursive nature of Smith's work as a means to understand its derivation, sources, and influences; it has replaced an older perception of Smith as inspired prophet-founder of the new political economy with an effort to interpret his work in the context of other, adjacent and contemporary forms of inquiry. Collectively, such work highlights the varied and disparate discourses which informed Smith's thinking on economic and other matters and seeks to understand how the complex and diverse forms of interaction with and assimilation of aspects of these philosophical and other discourses may have contributed to the formation of Smith's work—and hence, must also figure in our own attempts to read it.This paper, by exploring a strand of physiological language and imagery which runs through Wealth of Nations and considering it in the context of new developments in Scottish physiological research in the middle decades of the eighteenth century, also seeks to understand Smith's work by examining its relations with contemporary philosophical discourse. Where other recent accounts of Wealth of Nations have reassessed its relationship with moral, political and legal discourses, it will... (shrink)

This book is a meditation on the different aspects of colour, particularly its relationship to healing. Drawing on examples from natural science and spiritual science, Klocek focuses on the real essence of colours and how they relate to human beings in our physical body and soul. From Newton to Rudolf Steiner, and including the development of artistic pigments, this enlightening book shows how colour can be linked to healing with artistic therapies, homeopathy and flower essences.Illustrated in colour with numerous (...) diagrams and examples of art from the Middle Ages to the twentieth century, this book offers surprising insights into a subject that is integral to our everyday life and development. (shrink)

It may seem trivial to state that one of the major trends in biological investigation consists in an attempt to explain the structural and functional aspects of living matter in chemical terms, in an effort to obtain insight into the equivalent of macroscopic phenomena on the molecular level. I am sure you are aware of, and this meeting of the Association has brought ample additional evidence, in how many fields this tendency has become apparent. It can be recognized in (...) genetics with the molecular analysis of chromosomes and the enzymatic or metabolic interpretation of hereditary properties like the eyecolor of Drosophila. In a purely morphological branch like histology we do not ask merely for a differentiation of stained cell structure but we ask for the nature of the staining reaction; in nerve physiology we try to interpret conduction as alterations of protein lipoid layers; or in pathology where the age old syndrome of inflammation is explored with biochemical methods. I should mention molecular models of membranes and cell surfaces, the molecular interpretation of secretion and of the macroscopic phenomena of metabolism. Yet insofar as this yield of data could be designated as a trend, it would rather seem to be the natural outcome to be expected from the application of the analytic method of science. In one instance, however, this approach has been carried farther than in all the other fields, and it would seem to be worthwhile to pause for one moment to ask whether this case is important merely because of its technical implications or whether it is meaningful in a wider sense. (shrink)

Music education is one of human kind most universal forms of expression and communication, and it can be found in the daily lives of people of all ages and cultures all over the world. As university life is a time when students are exposed to a great deal of stress, it can have a negative impact on their mental health. Therefore, it is critical to intervene at this stage in their life so that they are prepared to deal with the (...) pressures they will face in the future. The aim of this study was to see how music education affects university students’ mental health, with emotional intelligence functioning as a moderator. The participants in this research were graduate students pursuing degrees in music education. Non probability convenience sampling technique was used to collect and evaluate the data from 265 students studying in different public and private Chinese universities. The data was gathered at a time, and therefore, the study is cross-sectional. The data was collected from January 2022 till the end of March 2022. Many universities have been closed because to COVID-19, therefore data was also gathered online through emails. The data was analyzed quantitatively using the partial least squares –structural equation modeling technique. The findings backed up the hypotheses. The results revealed that there is a significant effect of music education on student’s mental health. Also, emotional intelligence as a moderator significantly and positively moderates the relationship between music education and students’ mental health. Music has numerous physiological aspects, and listening to it on a daily basis may be beneficial to your general health and well-being. Furthermore, musicians and music students with a high level of emotional intelligence have a better chance of not just performing well in school, college and university or in the music industry, but also of maintaining mental health and improving it. (shrink)

What processes of the brain or the mind can explain the uniquely personal experience we have of smelling a rose, or feeling the pain of toothache, or seeing the point of a newspaper cartoon, or sensing a pang of post-modernist angst in the run up to the Millenium. The phenomenon of humanhigher-order consciousness has puzzled philosophers, naturalists, and theologians down the ages. Now, somewhat belatedly, consciousness has caught the interest of scientists, some of whom believe they are on the brink (...) of discovering its basis in neurobiological processes. This book, drawing together leading figures from the spheres of science and philosophy, is about the prospects of finding a scientific explanation of consciousness. And it is also about how our view of ourselves could be affected by such a scientific explanation. Until recently, the vast complexityof the brain had kept researchers from tackling the thorny topic of consciousness. But now, new imaging techniques are revealing many of the brain's mysteries to neuroscientists, while some researchers in the field of artificial intelligence believe they will be able to replicate consciousness withsilicon and circuitry. Meanwhile, philosophers continue to take issue with the methodology used by science to investigate this phenomenon. These are the issues that are debated in this book, in which exponenets of each view have the opportunity to argue their case, and the result is a collectionthat will both enlighten all those interested in the question of consciousness, and stimulate debate among those at the forefront of research in the many fields now investigating it. (shrink)

It was not long ago when the consciousness was not considered a problem for science. However, this has now changed and the problem of consciousness is considered the greatest challenge to science. In the last decade, a great number of books and articles have been published in the field, but very few have focused on the how consciousness evolves and develops, and what characterizes the transitions between different conscious states, in animals and humans. This book addresses these questions. Renowned researchers (...) from different fields of science (including neurobiology, evolutionary biology, ethology, cognitive science, computational neuroscience and philosophy) contribute with their results and theories in this book, making it a unique collection of the state-of-the-art of this young field of consciousness studies. - First book on the topic - Focus on different levels of consciousness, including: Evolutionary, developmental, and functional - Highly interdisciplinary. (shrink)

This study is part of a larger exploration of ‘talk and cure’ that combines the examination of talk-in-interaction, with nonverbal displays, and measurements of the client’s and therapist’s autonomic arousal during therapy sessions. A key assumption of the study is that psychotherapy entails processes of intersubjective meaning-making that occur across different modalities and take place in both verbal/explicit and nonverbal/implicit domains. A single session of a psychodynamic psychotherapy is analysed with a focus on the expression and management of affect, with (...) an aim to describe key interactive events that promote change in both semantic and procedural domains. The clinical dialogue is analysed discursively, with a focus on the conversational processes through which new meanings are jointly constructed and affective states shared; detailed attention is paid to nonverbal displays of affiliation and affect. Furthermore, we explore whether the interactional patterns implicated in joint meaning-making, as revealed by analysing the therapeutic conversation, have correlates in the autonomic arousal of the two protagonists, as reflected in their heart rates. Conversation analysis has still untapped potential to illuminate interactional patterns that underlie the practice of psychotherapy. In this exploratory study we suggest that discursive analyses of talk-in-interaction can be enriched through detailed focus on nonverbal displays as well as measures of physiological arousal. Drawing upon the analysis, we suggest that bringing the methodological strengths of language-based analysis into fertile dialogue with embodied quantitative data can help our explorations of what’s really going on in psychotherapy. (shrink)

Thirty-eight individuals (mean age: 34.8 years old) participating in a 3-month yoga and meditation retreat were assessed before and after the intervention for psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, and pro- and anti-inflammatory cytokines. Participation in the retreat was found to be associated with decreases in self-reported anxiety and depression as well as increases in mindfulness. As hypothesized, increases in the plasma levels of BDNF and increases in the magnitude of the cortisol awakening response (CAR) (...) were also observed. The normalized change in BDNF levels was inversely correlated with BSI-18 anxiety scores at both the pre-retreat (r = 0.40, p < 0.05) and post-retreat (r = 0.52, p < 0.005) such that those with greater anxiety scores tended to exhibit smaller pre- to post-retreat increases in plasma BDNF levels. In line with a hypothesized decrease in inflammatory processes resulting from the yoga and meditation practices, we found that the plasma level of the anti-inflammatory cytokine Interleukin-10 was increased and the pro-inflammatory cytokine Interleukin-12 was reduced after the retreat. Contrary to our initial hypotheses, plasma levels of other pro-inflammatory cytokines, including Interferon Gamma (IFN-γ), Tumor Necrosis Factor (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) were increased after the retreat. Given evidence from previous studies of the positive effects of meditative practices on mental fitness, autonomic homeostasis and inflammatory status, we hypothesize that these findings are related to the meditative practices throughout the retreat; however, some of the observed changes may also be related to other aspects of the retreat such as physical exercise-related components of the yoga practice and diet. We hypothesize that the patterns of change observed here reflect mind-body integration and well-being. The increased BDNF levels observed is a potential mediator between meditative practices and brain health, the increased CAR is likely a reflection of increased dynamic physiological arousal, and the relationship of the dual enhancement of pro- and anti-inflammatory cytokine changes to healthy immunologic functioning is discussed. (shrink)

Frailty is an age-related dynamic status, characterised by a reduced resistance to stressors due to the cumulative decline of multiple physiological systems. Several researches have highlighted a relationship between physical frailty and cognitive decline; however, the role of specific cognitive domains has not been deeply clarified yet. Current studies have hypothesised that physical frailty and neuropsychological deficits may share systemic inflammation and increased oxidative stress in different neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. However, the role of the (...) executive dysfunction should be investigated in a more detailed way using a multidimensional approach. With this aim, we conducted a review of the literature on the few experimental articles published to discuss the existence of a relationship between frailty and cognitive impairment in neurocognitive disorders, particularly focusing on the domain of executive dysfunction. The data suggest that physical frailty and cognitive decline, especially executive dysfunction, are two aspects strongly linked in mild and major neurocognitive disorders due to Alzheimer's and Parkinson's disease. In light of this, a new framework linking ageing, cognitive decline, and neurodegenerative diseases is needed. In order to analyse the effects that ageing processes have on neural decline and neurocognitive disease, and to identify relevant groups of users and patients, future longitudinal studies should adopt a multidimensional approach, in the field of primary prevention and in the continuum from mild to major neurocognitive disorder. (shrink)

As the word “optics” was understood from antiquity into and beyond the early modern period, it did not mean simply the physics and geometry of light, but meant the “theory of vision” and included what we should now call physiological and psychological aspects. From antiquity, these aspects were subject to geometrical analysis. Accordingly, the geometry of visual experience has long been an object of investigation. This chapter examines accounts of size and distance perception in antiquity (Euclid and (...) Ptolemy) and the Middle Ages (Ibn al-Haytham), before turning to "natural geometry" in Kepler and Descartes. It finds a purely mechanical realization of natural geometry in Descartes (primarily in his L'Homme, 1664), in which he conceives states of the visual system as varying in accordance with distance, much as his geometrical compasses vary their spatial relations in accordance with geometrical proportions. This reading challenges the notion that a two-dimensional sensation (without three-dimensional phenomenality) was universally accepted prior to the nineteenth century by positing a direct psychophysiological account of the experience of distance in Descartes. It thereby challenges the interpretations of Descartes on natural geometry of George Berkeley, Nancy Maull, Margaret Wilson, Erwin Panofsky, and Jonathan Crary. (shrink)

We provide to readers the 11th volume of the "Czech-Polish-Slovak Studies in Andragogy and Social Gerontology" series. We are delighted to announce that the presented study is the result of the work of scientists from seven countries: Austria, China, Ghana, Hungary, Japan, Poland, and Russia. This international collection of texts is part of the global discourse on the determinants of adult education and the functioning of people in late adulthood. The 11th volume is a collection of research results that show (...) both the positive and negative dimensions of ageing through the prism of research experience from various geographical and cultural areas. The researchers invited to the presented volume tried to illustrate the issues assigned to the following topics: ageing with dignity; retirement age; assumptions and conditions resulting from living in the home; the relationship between challenges concerning life expectancy and needs; care and ageing services; and foundations and potential changes in pension systems. The research results presented in this volume have a common denominator, which is caring for the quality of life of the older people regardless of their place of residence. Thus, the study "Between Successful and Unsuccessful Ageing: Selected Aspects and Contexts" brings new insights from scientists who scrupulously characterize the complexity of processes that affect the positive and negative conditions of functioning in old age, which is a mosaic of various nuances. Inviting readers to familiarize themselves with the content of the monograph, we would like to thank the reviewers who contributed to the improvement of the quality of the texts and open new fields for participation in further joint publishing projects. (shrink)

For much of the twentieth century, plant physiologists considered themselves in an ideal position to study and explain the functions and processes of plants. Much of that authority stemmed from plant physiologists’ long-standing commitment to experimental control and the integration of the physical sciences into biological practice. This article places plant physiology back in the center of the story of the recent life sciences. It shows the development of parallel experimental research programs into environmental as well as genetic effects on (...) growth and development in plant physiology and genetics, and notes that the pursuit of an experimental environment was celebrated as much as (and occasionally more than) a molecular vision of life throughout most of the twentieth century by much of the plant science community. Thus, this article concludes that the history of the recent life sciences needs new complementary narratives of plant physiology with genetics, new concepts with technological tools, and plant-sized scales with the molecular. The history of the ‘Age of Biology,’ as the plant scientists saw it, helps confront the issue first posed by Evelyn Fox Keller, namely that the history of genetics has overshadowed a larger history of experimental life science. My answer here is through a larger narrative of the rise of the complementary experimental sciences of genes and environments in the life sciences. (shrink)

ObjectiveAre people with a characteristically large physiological sway rendered particularly unstable when standing on a moving surface? Is postural sway in standing individuals idiosyncratic? In this study, we examine postural sway in individuals standing normally, and when subtle continuous sinusoidal disturbances are applied to their support platform. We calculate consistency between conditions to verify if sway can be considered characteristic of each individual. We also correlate two different aspects of participants’ responses to disturbance; their sway velocity and their (...) regulation of body orientation.MethodsNineteen healthy adults (age 29.2 ± 3.2 years) stood freely on footplates coaxially aligned with their ankles and attached to a motorized platform. They had their eyes closed, and hips and knees locked with a light wooden board attached to their body. Participants either stood quietly on a fixed platform or on a slowly tilting platform (0.1 Hz sinusoid; 0.2 and 0.4 deg). Postural sway size was separated into two entities: (1) the spontaneous sway velocity component (natural random relatively rapid postural adjustments, RMS body angular velocity) and (2) the evoked tilt gain component (much slower 0.1 Hz synchronous tilt induced by the movement of the platform, measured as peak-to-peak (p-p) gain, ratio of body angle to applied footplate rotation).ResultsThere was no correlation between the velocity of an individual’s sway and their evoked tilt gain (r= 0.34,p= 0.15 andr= 0.30,p= 0.22). However, when considered separately, each of the two measurements showed fair to good absolute agreement within conditions. Spontaneous sway velocity consistently increased as participants were subjected to increasing disturbance. Participants who swayed more (or less) did so across all conditions [ICC(3,k)= 0.95]. Evoked tilt gain also showed consistency between conditions [ICC(3,k)= 0.79], but decreased from least to most disturbed conditions.ConclusionThe two measurements remain consistent between conditions. Consistency between conditions of two very distinct unrelated measurements reflects the idiosyncratic nature of postural sway. However, sway velocity and tilt gain are not related, which supports the idea that the short-term regulation of stability and the longer-term regulation of orientation are controlled by different processes. (shrink)

Serious games are an effective method of reproducing aspects of the complex interplay between environments and stakeholders in business situations. In the game we describe here, The Sustainable Port, players experience what it is like to make decisions in such a complex environment. Their aim in the game is to grow the Port of Rotterdam while keeping economic growth in balance with sustainability goals. In this study, we assessed whether experienced Port of Rotterdam employees (PoR employees) show different psychophysiological (...) patterns, and more specifically EAR-derived features, compared to students. We did this on the assumption that physiological patterns will tell us something about how people who are familiar with the environment of the Port of Rotterdam, more specifically Port of Rotterdam employees, make decisions compared to those lacking such familiarity.Our sample consisted of 28 PoR employees and 65 students, all of whom played The Sustainable Port game and had their faces recorded with a camera. The Eye Aspect Ratio was extracted from these recordings and then from those we extracted EAR-derived features. Our results show that Port of Rotterdam employees perform better than students and that the two groups are characterized by different physiological variations in their EAR-derived features. A logistic regression model used to identify PoR employees and students obtained an F1 score of 0.62, a PR AUC score of 0.64, and a ROC AUC score of 0.70. performing significantly above baseline suggesting the effectiveness of using EAR-derived features for this task. Our interpretation was further confirmed by a pseudo-R2 score used to evaluate the goodness of fit of a logistic regression model on the entire dataset. We found that Port of Rotterdam employees had a lower variation in blink rate per minute (blinks/m) and higher variation in the root mean square difference of successive difference in blinks (RMSSD), the consecutive difference between two continuous blinks. Moreover, this study shows that our methods were robust enough to negate the effects of confounders, such as biological sex and age that affect some other studies that analyze blinks. (shrink)

This last result leads, rather naturally, to some concluding observations and a series of questions for further investigation. These case studies show that in all of the sites examined, the institutionalization of molecular biology as a “discipline” was primarily driven by the need to separate groups of practitioners with divergent but overlapping interests within the local context. Thus molecular biology was contingently separated from agricultural or medical biochemistry, virology, work on the physiology of nucleic acids, and so forth for contingent (...) local institutional reasons. This makes it even more pressing to try to understand how molecular biology came to be delimited on a larger scale. How did it come to be a discipline with specific intellectual content (or did it?), including some problems, tools, and practices and excluding others? How did it gain authority as the forefront biological science by the mid-1960s? We need to understand the ways in which the tensions between different practices, projects, aims, understandings of the goals of molecular biology, and so on were resolved, on what scale and in what venues, so that something approximating the political character of a discipline, rather than a federation, was achieved. If these case studies provide a sound starting point, it will nevertheless prove difficult to answer the interconnected questions implicit here satisfactorily.One means of getting at such questions that should prove of considerable interest is to examine carefully the work of those who were widely cited in the papers of the late fifties through the mid-seventies by the people now considered major founders of molecular biology. By studying the contributions of those who are now omitted in the standard histories and recollections, we will gain a clearer sense of the possibilities that were open as molecular biology took shape. It is already widely recognized that the contributions of a number of biochemists have been given short shrift, but (as the example of Ernest Gale in Rheinberger's study illustrates) there are a great many more figures whose line of work were then crucial but who are now overlooked.6 To understand both what molecular biology was at the time of its early institutionalization and what is has become, it will be enormously helpful to understand at what point the definition or ideology “hardened” and the grounds for inclusion and exclusion of individuals and lines of work were reformed. Studies of this sort are appropriate in many other areas as well, of course; in general, they should different histories, political standing, and institutional bases of those disciplines in their national cultures. It is likely (but a matter for investigation!) that such differences influenced the opportunities for introducing new bench practices, if in no other way than by delimiting the niches within which certain practices could be initiated.7 And since new practices can fail to achieve their objectives, can transform the direction of work and disciplinary allegiances of their practitioners, can lead to only routine results, or can open up important new vistas, the character of the available niches from which to work can prove to have a strong influence on the direction that new work takes if and when it starts to flourish. A key aspect of this problematic (not yet adequately studied, I believe) is the problem of drawing boundaries between different kinds of work and determining where each should fit among established disciplines and/or within some new construct. To the extent that an “international” solution is ultimately achieved to such problems, it must surely be achieved in light of initially different ways of dealing with it in different countries.Underlying work of the sort we have been exploring is the thorny problem of how best to contextualize the work being studied. This, I believe, is one of the major historiographic problems that we must face in the history of science. It is by no means a new problem, of course, but a particularization of the age-old problem of the (seeming) overdetermination of historical events. If we deal with local cultures, to understand how they develop and their fate we need to understand their location within larger cultures. But it is utterly unclear how to draw appropriate boundaries on the relevant larger culture(s). As even this brief discussion has shown, institutional cultures, the cultures of sponsoring agencies, “the” culture of science (or of biological science, physical science, etc., as appropriate), and national cultures all can provide relevant contexts, all can occasionally determine the fate of work undertaken in a particular local context. The potentially intractable problem of delimiting the boundaries of investigation looms large here, but it is one that must be faced explicity if we are to profit fully from the enormously stimulating investigations of local cultures exemplified in the four papers published in this symposium. My own view is that we have no abstract standard available for determining which boundaries are appropriate to a given study, and, indeed, that no single contextualization is adequate to the examination of any given case, but that, nonetheless, we can (at least sometimes) distinguish useful and explanatory delimitations of the larger context from others that prove to be misleading.Against this background, I hope that the four papers published in this special issue will stimulate the readers of the JHB to carry out similar studies—that is, studies that seek to characterize and contextualize local experimental cultures —over a wide range of cases. I also hope that some of those who take up this challenge will deal with the larger questions raised by the need to find a way of balancing different, sometimes competing, contextualizations of such studies. The fact that any given case requires multiple contextualizations, resulting in multifaceted representations no one of which is alone adequate, will surely land us in fascinating, hopefully fruitful and productive, controversies. (shrink)

Mitochondrial homeostasis serves as a cornerstone of cellular function, orchestrating a delicate balance between energy production, redox status, and cellular signaling transduction. This equilibrium involves a myriad of interconnected processes, including mitochondrial dynamics, quality control mechanisms, and biogenesis and degradation. Perturbations in mitochondrial homeostasis have been implicated in a wide range of diseases, including neurodegenerative diseases, metabolic syndromes, and aging‐related disorders. In the past decades, the discovery of numerous mitochondrial proteins and signaling has led to a more complete understanding (...) of the intricate mechanisms underlying mitochondrial homeostasis. Recent studies have revealed that Family with sequence similarity 210 member A (FAM210A) is a novel nuclear‐encoded mitochondrial protein involved in multiple aspects of mitochondrial homeostasis, including mitochondrial quality control, dynamics, cristae remodeling, metabolism, and proteostasis. Here, we review the function and physiological role of FAM210A in cellular and organismal health. This review discusses how FAM210A acts as a regulator on mitochondrial inner membrane to coordinate mitochondrial dynamics and metabolism. (shrink)

It is well known that the belief that music is inherent in the beating of the pulse was widely held throughout the Middle Ages. Numerous brief but explicit statements of this belief, and of the associated ideas that music is present in other bodily rhythms and or in the virtues and humors can be culled from the writings on music of music theorists and encyclopedists. For such writers, the idea of the musicality of pulse was, of course, one specific expression (...) of the more general notion that musical harmonies inhere in the body and soul of man. The supposed links between music and human physiology and psychology were, however, not only of interest to writers on music: as might be expected, physicians too concerned themselves with the subject. Moreover, certain medical writers who flourished in the north Italian studia during the fourteenth and fifteenth centuries seem to have been much readier than either musical theorists or natural philosophers to provide their readers with detailed discussion of the nature of the music of pulse. The works of these physicians span nearly two hundred years of the teaching of the Italian schools and represent a fairly continuous tradition. Their views not only throw light on the concept of pulse music itself, and hence on one aspect of late medieval handling of the ancient theme of the harmonies of the universe; they also illustrate, in one small area, something of the nature of the actual application in medical training of the venerable tradition linking medicine with the liberal arts and with philosophy, a tradition institutionalized in the very existence of the faculties “of arts and medicine” of the Italian universities. For academic writers on medicine, indeed, the value of a knowledge of music for the understanding of pulse became one of a set of axiomatic illustrations of the importance of an education in liberal arts for physicians. To what extent this particular prescription was seriously intended or taken the following discussion of the opinions and sources of some of the academic medical writers on the music of pulse may help to show. jQuery.click { event.preventDefault(); }). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Ambiguities of Mild Cognitive ImpairmentTim Thornton (bio)Keywordsclassification, disease, mild cognitive impairment, normative, valuesCorner and Bond's paper (2006) raises some key ethical questions about the classification and diagnosis of mild cognitive impairment (MCI). In this commentary, I wish to revise some of the general issues about the classification of mental disorder raised by this particular classificatory concept. The central issue raised is the connection between the pathologic status of (...) a condition and what I term the plain facts about the frequency and nature of its symptoms.There are a number of ethical questions raised by applying the label of MCI. Centrally, perhaps, is the concern, illustrated by the case vignettes, that a diagnosis carries negative repercussions that might outweigh the more narrowly medical advantages of an early diagnosis. But although that concern may be appropriate, such ethical complications are a danger of any psychiatric classification or diagnosis, even the most well grounded. Any psychiatric diagnosis can carry a danger of stigma, for example.What seems to make such ethical concerns more serious in this case—at least to a philosopher outsider—is the implicit further concern that MCI is not a real, objective, or, to use a more medical term, valid category or classification. If it is not valid, then any negative connotations of the diagnosis will not be outweighed by medical technological achievements. In other words, the further ethical issues are given much greater weight if the question of validity is not satisfactorily resolved.The question of the reality, objectivity, or validity of MCI can be divided into two issues:1. Is MCI a real, objective, or valid feature of psychological phenomenology?2. Is MCI a real, objective, or valid psychological illness, disease, or pathology?A condition might be a real, objective, or valid feature of psychological phenomenology without being a real illness. It might be some other aspect of human living. Szasz (1960) suggests that this is the case with mental illness (he might more properly say "so-called mental illness") as a whole. But, less controversially, the unusual ability to calculate, mentally and in a flash, the date of future Easter Sundays is a genuine feature of human living—some people possess the ability even if most do not—without either it, or its lack, being an illness. Being real as an illness is a very specific kind of being. It is this, I suggest, that raises difficulties in the case of MCI by contrast with the easier question of whether something is a genuine feature of human living in some other way. [End Page 21]From "normal" and "normative" to "correct" and "incorrect"Corner and Bond (2006) usefully suggest that the question of whether MCI is real is made more difficult by an ambiguity in the sense of the word normal. They suggest that although "physiologic and cognitive decline is assumed to be a normal experience" this still leaves "boundary problems" about "distinguishing normal aging from disease" (Corner and Bond 2006, 3–4). Thus, if the symptoms of MCI are continuous with the ordinary phenomena of physiologic and cognitive decline, then they might also be merely normal. But this does not settle the status of MCI because normal can mean either "normative, that is, usual; or it can mean nonpathologic" (Corner and Bond 2006, 4).On the assumption that MCI is at least continuous with phenomena that are normal, then its symptoms might be normal in the sense of usual but nevertheless pathologic: an inevitable illness. Or they might be usual and nonpathologic, that is, merely a feature of aging that, although regrettable, lacks the connotations of illness (e.g., the appropriateness, if not the possibility, of treatment). (In principle on the assumption in play—that the symptoms of MCI are normal—they might be unusual but nonpathologic akin, for example, to an improved ability to solve crosswords with age that might affect a small lucky proportion of the population. Perhaps such a crossword puzzler might be reassured by their doctor: "Well that is very unusual but there is no need to worry: it is not a symptom of any illness. You are perfectly normal.")Thus the question "Is MCI normal... (shrink)

Human beings pass through a series of life stages since birth. These stages beginning at the infancy even in the mother’s womb are accompanied with a period extending to the senescence and the last stages of the life. Creation of human beings and various stages of the life are mentioned in the Qurʾān. Besides, it is referred to the senescence. In addition to the expressions sheikh, shayb, ʽajūz and kibar indicating to the senescence, ardhal al-ʿumur is also pointed out in (...) the Qurʾān in this regard. This article aims to identify in which context and meaning the wording regarding ardhal al-ʿumur and senescence are used in the Qurʾān and to reveal the relation between these terms. Since, the term ardhal al-ʿumur and senile dementia are directly correlated in the commentaries usually and the interpretations build the perception that these two expressions are almost synonyms. Are ardhal al-ʿumur and dementia closely associated with each other? Are the other terms in the Qurʾān indicating to the senescence correlated with the dementia? Our study aims to explain the expression ardhal al-ʿumur in the Qurʾān in this regard. Furthermore, the other terms regarding the senescence expressed in the Qurʾān are reviewed in this respect. SUMMARY The Qurʾān tells the creation of human beings and refers to the various stages of their lives as well. The explanations beginning with the creation state the prenatal period, infancy and childhood, adolescence and adulthood of human beings. The Qurʾān refers to the senescence as well, the last stage of the life. In this regard, ardhal al-ʿumur, sheikh, shayb, ʽajūz and kibar are the terms in the Qurʾān associated with the senescence. Especially nowadays, the senescence is a considerable focus of the science, besides being mentioned in the Qurʾān. This article discusses the subject scientifically as well. The senescence is defined with various aspects since it expresses a period having physical, psychological and social dimensions. Furthermore, certain classifications regarding the senescence are made and physiological changes associated with the chronological age are more emphasized. It has been indicated that the senescence is divided into two: biological and chronological aging. According to this chronological aging is the same for everyone while biological aging varies from individual to individual. The senescence is acknowledged as the last development stage of the human life in terms of social sciences and considered as an on-going universal process between birth and death. Therefore, the senescence is interpreted relatively while the aging is interpreted universally. So, everyone gets old; however, the senescence means a life period varying from individual to individual. The senescence affects the individual both health-wise and psychologically, sociologically and economically. In other words; the senescence, a tough period, is a phenomenon which deeply affects the human beings and all their characteristics making them exist. The senescence is addressed in the Qurʾān with various expressions. Ardhal al-ʿumur, foremost among these, is mentioned twice in the Qurʾān (al-Nakhl 16/70, al-Ḥac 22/5). The exegetes generally consider ardhal al-ʿumur as the physiological exhaustion of an individual due to aging and as the period when dementia is experienced. The characteristics of the stage called as ardhal al-ʿumur in the Qurʾān are explained with the following statement: turning into a person who does not know anything from the person who used to know many things. Just because of this sentence, ardhal al-ʿumur is construed with dementia. Are arzali’l-ʽumur and dementia directly interrelated? This article also reviews the other terms stated in the Qurʾān regarding the senescence from this aspect. Sheikh, another expression stated in the Qurʾān regarding the senescence, is mentioned four times (Hūd 11/72, Yūsuf 12/78, al-Qaṣaṣ 28/23, al-Muʼmin 40/67) and it is described with the word kabīr in two of them. The lexical meaning of sheikh is an old person in terms of age and appearance. Moreover, sheikh is used as an adjective to describe the individuals who have wisdom in customs. So, the word sheikh both means an individual who is well on in life and is the expression of supremacy in terms of knowledge and experience. Shayb, another expression stated in the Qurʾān regarding the senescence, is mentioned three times (Maryam 19/4, al-Rūm 30/54, al-Muzzammil 73/17) and means hair greying and describes a physiological change in the senescence. ʽAjūz stated in the Qurʾān for the senescence is mentioned in four different chapters (Hūd 11/72, al-Shuʽarā’ 26/171, al-Ṣāffāt 37/135, al-Dhāriyāt 51/29) and expresses incapacity of performing many actions. ʽAjūz is another expression in the Qurʾān meaning elderliness. The senescence is implied with this expression too; however, the dementia is not mentioned. Kibar, the last wording associated with the senescence, is mentioned in six verses (al-Baqara 2/266; Āl-i-ʽImrān 3/40, Ibrāhim 14/39, al-Hicr 15/54, al-Isrā 17/23, Maryam 19/8). The word kibar means the senescence and physical power loss; nevertheless, is not interpreted as dementia. To our knowledge, the explanations regarding the senescence and dementia in most of the commentaries cannot be corresponded in the Qurʾān as if they are synonyms. This perception can be generated due to the statements pointing out the dementia in the lexical meaning of ardhal al-ʿumur. It is understood in the light of the data acquired by today’s science that the dementia is not a natural result of the senescence but rather one of its risks, which is already proved by the fact that the science discusses the dementia separately from normal aging process. Therefore, there is not a general picture of dementia including all elders. Thus, it is possible to define ardhal al-ʿumur as a later part of life which includes some elders and affects them physiologically, psychologically, sociologically, etc., in addition, they lose their mental faculties in that period. Each expression regarding the senescence in the Qurʾān reveals the picture of the senescence pursuant to the integrity of the Qurʾān. The senescence in the Qurʾān is an ineluctable reality. The fact that this period is clearly expressed in the verses aims that this reality can be perceived by human beings and they can be prepared for this period. Some problems that elders experience are also mentioned in the Qurʾān. When the other terms in the Qurʾān associated with the senescence apart from ardhal al-ʿumur are reviewed, it is seen that the aforementioned problems that may be observed at later ages are hair greying, bone diseases, incapability and weakness in doing some actions. Today, there are various disciplines concerning the elders and the information obtained from these disciplines shows that these problems are a lot more than the ones mentioned in the Qurʾān. However, it is not expected that the Qurʾān discusses the facts as a science book since it is a holy book. When ardhal al-ʿumur is evaluated in the light of scientific data, it appears as a sickness period when some elders experience mental problems such as dementia/blackout. On the one hand, there will be elders who experience these problems; on the other hand, there will be some who do not. All expressions regarding the senescence in the Qurʾān do not lead to the fact that the aging leads to the dementia directly. Ardhal al-ʿumur within the integrity of the Qurʾān expresses that senile dementia affects some individuals while it has not any impact on the others. Therefore, ardhal al-ʿumur is one of the life stages affecting not every elder but some of them. The fact that different terms are stated in the Qurʾān regarding the elders points out various aspects of the aging process creating different effects. The second important reason why the aging is mentioned in the Qurʾān is to emphasize the value of the elders and the respect that should be showed to them. Besides, it is also underlined in the Qurʾān that the elders are so precious that they cannot be left alone socially and psychologically. Furthermore, the elders are the individuals worthy of love and being valued. Thus, it is suggested in the Qurʾān to love, respect and honour the elders and to live with them regardless of whether they will experience ardhal al-ʿumur or not. Therefore, the human beings are reminded to look after the elders, esteem them materially and morally, as they deserve, and to act considering the characteristics of this period. (shrink)

: The thought of the Qurʾān consists of certain concepts. The concept of “fiṭrah” that expresses the physical and spiritual side of the people, is one of crucial concepts which stands for the conseption of the Qurʾān. Therefore this concept has become the one drawing attention of scholars from the earlies. Usually, the concept of “fiṭrah” is interpreted as the religion of Islam and the initial creation or the human potentiality of acception a religion and whether they can change or (...) not. In this context, it has been established a connection between the “word of khalqullah” in the Surah of Rūm and the same word in the Surah of Nisā. In this study, the essence of “fiṭrah” will be examined and the basic elements of “fiṭrah” will be focused on. Also, whether wisdom, affection, love, and ugliness are among the basic components of fiṭrah or not, will be discussed. In addition, whether there is any connection between the verse of “fiṭrah” and the words of “tabdīl” and “taġyīr” will be investigated. Summary: The Qur’ānic view of human has been set forth with certain concepts. According to our understanding, there is a strong relation between the Qurʾānic definition of human and the terms of tafsīr and ta’wīl. If the Qur’ānic view of human is put forth correctly, then the explanation and interpretation of the Qurʾān will also be more accurate. Therefore, we think that there is an important link between the characteristic of Qurʾānic view of human and the ta’wīl of naṣṣ. For this reason, we have based our study on the term, fiṭrah which explains the nature of human beings and the context of this term in the Qur’ān. In this regard we have tried to take into account in our comments the consistency through the mention of the term of fiṭrah that comes in the 30th verse of the surah al-Rūm with the relation to other verses. Main focus of the study is to see whether the essential aspects of human nature is in correlation with compassion, mental potentiality, power to produce, seeking for truth, wanting to do good and avoiding bad deeds. In the etymological dictionaries of Arabic language and in tafsir books the term of fiṭrah has been explained in various meanings such as “religion of Islam”, “unity of God”, “the first creation of human beings”, “mental capability”, “ability to accept the truth”, “initial agreement”, “pre-eternity of human destiny”, “inborn creed”, “tattoing”, “plucking females hairs” and “to geld animals”. The verse of “la tabdīla li khalqillāh” is explained that there should not be changed things and qualities which are parts of the nature of human being. The verse of "I am going to command humans and they are going to change God's creation" is associated with above mentioned fiṭrah verses. In this context neglecting to worship to Allah and taking means through other idols that are worshiped, sacrificing in the name of idols, replacing religious motives with other motives, denial of creed, making permissible acts impermissible or impermissible acts permissible, females plucking their hair, etc., have been interpreted as changing Allah’s creation. However, we do not think that the interpretation of nature that is mentioned in the verse regarding the replacement of Allah’s creation has no relation with the replacement of Allah’s creation which occurs in Surah al-Nisā. Because changing khalqullāh in al-Nisā is not to change fiṭrah which is accepted same as religion and there is no relation between two issues. The mention of nature along with the concept of religion comes to show the value of Islam is in accordance with human nature. Yet when the Qurʾān is interpreted in the correct manner, a better understanding of the human nature will be seen. The samples and types of i’rāb regarding the link between the terms of fiṭrah and dīn show that there is also a strong relation between religion and human nature. This shows that religion entails all the values and qualities that human nature contains. In the context of the Qurʾān, the term of fiṭrah consists of spiritual qualities, such as reflection, love, desire to find the truth, inclination to good deeds, avoiding bad deeds, creativity and worship rather than physiological qualities such as the desire to eat and drink, need of shelter and sexuality. These are core foundations of human nature which cannot be changed. However, these natural qualities can be lead the opposite direction. This is the reason why there is frequent mention of natures spiritual qualities in the Qurʾān. However, if the Qurʾān and the Sunnah are falsely interpreted, the core qualities of nature will be understood incorrectly which may not be a prototypical that the Qurʾān aims. The Qurʾān frequently makes mention and condemns those that do not use their logic, which comes to show the importance of nature. In order for the other nature qualities to be functional, first the logic must be functional. Likewise, since early ages people try to understand the objects in their environment and start to question them is again natures manifestation. The past and today's philosophical movements, scientific research and as a result the information and findings derived from them is a result of human nature. One of the main components of nature is the belief of the unity of God and acknowledging that the creator is Allah therefore comprehending that He is only worthy of worship. Thus, this belief provides the mental and emotional integrity of person. In times of difficulty, through the natural instinct people show towards the Creator is an act of the reaction shown which is coursed by natural creed properties. It should be said that another important natural human quality is love and affection. As the Qurʾān has expressed that human being is created from "alaq" also comes to the meaning of compassion. It is the human’s natural instinct to incline to those that he has compassion for. Once this inclination is made stronger the compassion turns into love. Desiring good or evil is also part of human nature as these two opponents are in men’s structure. Men being virtuous comes from choosing the good. Another important feature of human nature is desiring those that are aesthetically beautiful and disliking those that are aesthetically ugly. Men does not only desire those that are aesthetically beautiful but rather those that are spiritually attractive such as knowledge, modesty and bravery. It dislikes ignorance, lies and other bad qualities. Qurʾān’s phonetic structure can be counted as a proof to this. One of human’s natural instinct is to create and constantly update information. The word "khalq” is used commonly to bring anything to existence when it was absent totally, therefore this is used for mankind as a metaphor. As a result, it is possible to say that the most important human instinct qualities are reason, the ability of accepting of the unity of God, compassion, human and divine love, creativity, evoking good deeds, avoiding evil, valuing those that are ecstatically nice and avoiding those that are ugly. The different meanings and definitions of fiṭrah in tafsīr books and dictionaries such as dīn, pre-eternity of human destiny, initial agreement, and to geld animals are not the essential aspects of fiṭrah but the manifestations of the basic elements. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Preface: Virtual Entities in ScienceRobert Harlander, Jean-Philippe Martinez, Friedrich Steinle, and Adrian WüthrichIt is not only since the sudden increase of online communication due to the COVID-19 situation that the concept of the “virtual” has made its way into everyday language. In this context, it mostly denotes a digital substitute for a real object or process. Virtual reality is perhaps the best-known term in this respect. With these digital (...) connotations, “virtuality” has also been used in science and research: Chemists use virtual laboratories, biologists do virtual scanning of molecular structures, and geologists engage in virtual field trips. But the concept of the virtual has a much longer tradition, dating back to long before the dawn of the digital age. Virtual images and virtual displacements were introduced in classical physics already in the late seventeenth and eighteenth centuries, respectively. They represent auxiliary objects or processes without instantiation, with the purpose of efficiently describing specific physical systems. In today’s physics, the term “virtual” is mostly associated with the quantum world, first and foremost with the “virtual particle” of quantum field theory. It has become such an integral part of modern high energy physics that its ontological character may be considered to go beyond the purely auxiliary, which is typically associated with the virtual. [End Page 263]In other disciplines, however, use of the term virtual without a digital connotation is much rarer. While concepts like “virtual adrenaline” show up in physiological research around 1940s, and Charles Darwin, in a private note in January 1840,1 spoke of “virtual change” in the context of embryology, these examples seem to be singular occurrences of entities that were explicitly called “virtual.” The basic idea behind the terminology of the virtual, however, might be much more common, even outside of physics. The “invisible hand” in economics, or the “vital force” in biology, for instance, may carry aspects of a virtual entity, even if they have not been referred to that way.These different observations raise several questions about the status of virtual entities in science. What has led scientists to call one entity “virtual” and not another? Do all virtual entities in science have the same roots and meet the same characteristics? Are they more than auxiliary objects or processes? Why does physics seem to occupy a specific position with respect to the use of the notion of virtuality? These are some points that led us to discuss virtual entities in science during a workshop, out of which grew the present collection. We invited contributions that addressed the historical formation and philosophical interpretation of concepts of virtual entities in physics and other disciplines—in whatever terms they may come. The main goal of the workshop was to bring to the fore similarities and differences in the meanings and functions of these concepts, so as to be able to precisely characterize why certain entities are considered virtual in specific contexts, why a different terminology was often used in each individual case, and in what sense the virtual entities relate to the real world.The organization of the workshop was part of our project “The formation and development of the concept of virtual particles,” a subproject of the Research Unit “The Epistemology of the Large Hadron Collider,” funded by the Deutsche Forschungsgemeinschaft (DFG) and Der Wissenschaftsfonds (FWF). The workshop took place online on four consecutive Fridays in March 2021. It brought together contributors who discussed the role of the concept of the virtual in theoretical as well as experimental activities, and investigated into the origins of the terminology of the virtual as it was applied to the various disciplines of natural science. Dealing with historical, philosophical, but also methodological questions, the presentations covered a wide time range, from the Middle Ages to the present day. While physics naturally emerged as the dominant field, natural philosophy, computer science and biology were also addressed. The papers in this volume were contributed by participants in this workshop and approach the subject from different angles. [End Page 264]First, Friedrich Steinle provides us with an introductory piece that reflects on the specific meaning of the use of the term ‘virtual’ in science. He highlights and... (shrink)

The choroid plexuses (CPs) are involved in the most-basic aspects of neural function including maintaining the extracellular milieu of the brain by actively modulating chemical exchange between the CSF and brain parenchyma, surveying the chemical and immunological status of the brain, detoxifying the brain, secreting a nutritive “cocktail” of polypeptides and participating in repair processes following trauma. This diversity of functions may mean that even modest changes in the CP can have far-reaching effects. Indeed, changes in the anatomy and (...) physiology of the CP have been linked to aging and several CNS diseases. It is also possible that replacing diseased or transplanting healthy CP might be useful for treating acute and chronic brain diseases. This review focuses on the wide-ranging and under-appreciated functions of the CP, alterations of these functions in aging and neurodegeneration, and recent demonstrations of the therapeutic potential of transplanted CP for neural trauma. BioEssays 27:262–274, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

The main aim of this study is to test the validity of the Motivation, Engagement, and Thriving in User Experience (METUX) model (Peters et al., 2018) in higher education. We propose a process model in which we investigate how the need-satisfaction of digital learning tools within the interface sphere and task sphere accounts for engagement, learning, and well-being. A total of 426 higher education students drawn from two subsamples participated in this cross-sectional study. A structural equation model shows that interface (...) autonomy and competence satisfaction positively predict task autonomy and competence. Task competence, in turn, negatively predicts focused attention and positively predicts perceived usability and well-being. Task autonomy positively predicts perceived usability and reward. Based on our results, we provide some initial support for the METUX model in higher education. However, more validation work is needed to improve the scale that measures need-satisfaction in the interface and task spheres. Moreover, we find no support for the effect of task sphere on learning. Further investigations are needed into how METUX can be used in domain- and situation-specific contexts to account for increases in engagement, learning, and well-being. Finally, future studies need to include all aspects of the METUX model in order to fully test its validity. (shrink)

Change can be difficult to achieve, and system inertia may be considered relevant. There is a tendency for dynamic systems to enter into specific states characterized by stabilizing factors. The present work attempts to define inertia processes and explores these with regard to pro-environmental behaviour and decision-making. Inertia processes can be considered both within an organizational context and from the level of the individual, and may involve a number of psychological processes and aspects of the decision-making process. A few (...) suggestions for research are also presented. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Intersection of Medicine and ReligionJohn C. DormoisThe practice of medicine offers a host of rewards to the practitioner. Besides the obvious intellectual satisfaction of solving a difficult diagnostic problem or the ability to make a comfortable living, I have found the greatest personal sense of moral gratification when helping [End Page 196] families negotiate the most challenging event in life: making decisions at end of life. Whether the (...) condition was a ruptured intracranial aneurysm with brain death or a patient with far advanced cancer struggling with the choice between experimental chemotherapy or choosing comfort therapy at home surrounded by family for the remaining days of life, the moral courage required to provide the best guidance was considerable. In my early years of practice I didn’t call my actions in these situations “courageous” nor were there moral “guidelines” providing a blueprint. I knew I responded with empathy and compassion and that this ability had a lot to do with being raised in a religious or spiritual home. At the same time, I suspected that some of the lack of empathy and compassion I witnessed in some of my colleagues was related to the very training programs of physicians. This essay traces the origin of my moral and ethical concerns about medical education and my intention to reinvigorate the spiritual or existential voice in medicine.An early life experience had a great deal to do with shaping my moral development. At age seven my family traveled through the West Indies. My father’s amateur radio hobby meant that at every stop we would be greeted by one of his radio contacts. One stop in particular was life changing.Port au Prince, Haiti was an unknown place to this seven year–old, but to say it was a culture shock to a boy from Kansas would be an understatement of epic proportions. It was during this visit that I experienced true poverty in its most blatant form. In downtown Port au Prince I saw limbless beggars and the deformed from polio and malnutrition. But it was the sight of the garbage dump near the center of town that changed my world forever. There, among piles of detritus, I saw children and families making their home in the dump. They had hollowed out a sort of cavern in the piles of trash that served as a place of refuge from both the rain and the sun.This experience in many ways has served as a framework and background for my life. Although seen through the eyes of a seven year–old, the picture can only be adequately understood within the context of being raised by religiously faithful parents, parents free of hypocrisy whose lives personified the best in Christian virtues and practices. These early experiences planted the seeds that would only fully blossom some 60 years later.Medical school was a demanding but exhilarating experience. Each day was a day of discovery … anatomy, physiology, pathology … all subjects opening up a whole new world to explore. Internal medicine suited me best since it was the specialty that most closely integrated all the basic sciences necessary to arrive at a diagnosis. I loved the elegance of endocrinology in particular where a given hormone mediator could cause widely different effects if present in excess or completely absent. But I was in the end drawn to cardiology since it combined complex physiology with my avocation, the love of running.There was, however, a disturbing aspect of medicine education that I observed affecting many of my classmates. Although I can vividly recall the enthusiasm that all of us shared as we donned our white coats for the first time and envisioned a future of caring for our patients, things gradually and insidiously changed over the next four years. The altruism and empathy that was so evident in the early years gradually lessened as graduation approached. I could not help being struck by this change and wondered at the time why that should happen. I had no insight then that what I had observed was a well recognized consequence of the medical school experience. I’m sure that the passage from professional training to practice in... (shrink)

Who Are You, Mrs Walter Shandy, Aberratio Naturae? The aim of this paper is to examine the critically unacknowledged aspect of the canonical Tristram Shandy by Laurence Sterne: the authorial delineation and narrative management of the character of Mrs Shandy, who is a silent presence in the background even though the pivotal personal events for the narrator of this spoof-autobiography are his conception and birth. The novel, otherwise thoroughly structurally and thematically experimental, seems to be fossilized in the ancient and (...) Christian philosophers' assumptions about the physical incompleteness of the "weaker vessel" and the malign influence of her disturbing physiology, which for centuries fed into the ontological concept of a woman as Nature's aberration, aberratio naturae. Mrs Shandy's muteness, a striking contrast to her husband's verbosity, her absence and exclusion from the affairs of the male dominated household seem to run counter to the novel's progressive form and linguistic audacity, the sociological shifts slowly taking root and medical discoveries made before and during this age of paradoxes. (shrink)

This paper furthers the understanding of Nietzsche's project of increasing the prevalence of higher individuals. I do this by opposing the dominant tendency in Nietzschean scholarship of constructing a single ideal-type. I argue that Nietzsche actually describes multiple higher types, with incommensurable physiological and psychological characteristics, and that attempts to collapse these into one type obscure the nuance and richness of his thought. Furthermore, I claim that higher types are not ahistorical ideals; instead, their emergence relates closely to existing (...) psychological and physiological conditions in society. The artistic-genius type, for example, is characterised by his sensitivity to stimuli and plays a vital role in injecting creativity into culturally uniform societies. He is, however, a counter-productive role model for diverse modern societies, characterised by an abundance of stimuli and widespread reactivity. In response to such conditions, Nietzsche extols the virtue of a peculiarly anti-modern type, who cultivates independence from stimuli. Interpreting higher types as multiple and historically situated is vital to carrying out the normative aspect of Nietzsche's philosophy. This role is performed by the philosophical-physician, who surveys the physiological and psychological conditions of his own age and attempts to exploit these conditions to produce future higher individuals. (shrink)

Melatonin, the chief hormone of the pineal gland, is produced and secreted into the blood in a circadian manner with maximal production always occurring during the dark phase of the light dark cycle. Whereas the 24h rhythm of melatonin production is very robust in young animals including humans, the cycle deteriorates during ageing. The rhythm of melatonin can be substantially preserved during ageing by restricting the food intake of experimental animals; this same treatment increases the life span of the animals. (...) The exogenous administration of melatonin to non‐food restricted animals also reportedly increases their survival. Moreover, melatonin has been shown to have immunoenhancing effects and oncostatic properties. The implication of these studies is that melatonin may have both direct and indirect beneficial effects in delaying ageing processes or it may retard the development of processes (e.g., immunodeficiency and tumor growth) which contribute to a reduced life span. (shrink)

Age-specific mortality rates have been used to illustrate certain aspects of the characteristics of old age. A consideration of the experience of the ageing person in his fifties and early sixties suggests that during this period he comes to recognize death as being an increasingly common characteristic of his age group. Thus the standard procedure for studying old age problems in a sample of people over the age of 65 may miss the period of life when people are making (...) the crucial adjustments to old age and may give a distorted view of some gerontological problems. Certain demographic aspects of old age are considered in detail with regard to the occurrence of, first, widowhood and, second, social isolation. (shrink)

Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions, focuses on the key challenges underlined by the United Nations during the Decade of Healthy Ageing (2021-2030). The authors introduce studies in areas crucial for older people, their families, and communities, such as combatting ageism, age-friendly environments, and care provision. The volume also examines issues linked to the global, national, regional, and local implementation of age-specific and intergenerational solutions, initiatives, and programs towards achieving the United Nations Sustainable Development Goals (...) (SDGs). The collection contains chapters representing research and practical recommendations from various disciplines, such as critical studies, geographical gerontology, legal studies, public health, and sociology. This volume is an asset to academic and professional communities interested in theories of ageing as well as public services and ageing policies. In addition, the book aims to help students, practitioners, and people working in government, business, and nonprofit organizations. (shrink)

Next SectionThe principle of respect for autonomy has shaped much of the bioethics' discourse over the last 50 years, and is now most commonly used in the meaning of respecting autonomous choice. This is probably related to the influential concept of informed consent, which originated in research ethics and was soon also applied to the field of clinical medicine. But while available choices in medical research are well defined, this is rarely the case in healthcare. Consideration of ordinary medical practice (...) reveals that the focus on patient choice does not properly grasp the moral aspects involved in healthcare. Medical decisions are often portrayed as if doctors and patients in confidence confront specific decisions about examinations or treatment, yet the reality often involves many different participants, with decisions being made over time and space. Indeed, most of the decisions are never even presented to patients, as it would be unethical to suggest something that is not medically justifiable. The options patients do confront are somewhat arbitrarily constructed within the narrow framework of both what is deemed to be medically appropriate and how the healthcare system is organised practically. While the autonomy discourse has proven valuable, a failure to distinguish between the fields of medical research and clinical medicine has generated a focus on patient choice that does not reflect what is really at stake in healthcare settings. This is alarming, because the current discourse misrepresents medical practice in a way that actually contributes to bioethical self-delusion. (shrink)

The mobility restrictions related to COVID-19 pandemic have resulted in the biggest disruption to individual mobilities in modern times. The crisis is clearly spatial in nature, and examining the geographical aspect is important in understanding the broad implications of the pandemic. The avalanche of mobile Big Data makes it possible to study the spatial effects of the crisis with spatiotemporal detail at the national and global scales. However, the current crisis also highlights serious limitations in the readiness to take the (...) advantage of mobile Big Data for social good, both within and beyond the interests of health sector. We propose two strategical pathways for the future use of mobile Big Data for societal impact assessment, addressing access to both raw mobile Big Data as well as aggregated data products. Both pathways require careful considerations of privacy issues, harmonized and transparent methodologies, and attention to the representativeness, reliability and continuity of data. The goal is to be better prepared to use mobile Big Data in future crises. (shrink)

An EXACT reproduction from the original book BODY AND WILL: BEING AN ESSAY CONCERNING WILL IN ITS METAPHYSICAL, PHYSIOLOGICAL and PATHOLOGICAL ASPECTS by Henry Maudsley first published in 1884. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into (...) print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. (shrink)

Die individuellen und gesellschaftlichen Folgen des demographischen Wandels rücken moralische Fragen, die den angemessenen Umgang mit älteren Menschen und die sinnvolle Gestaltung des Lebens im Alter betreffen, verstärkt in den Mittelpunkt öffentlicher Aufmerksamkeit sowie medizin- bzw. pflegeethischer und gesundheitspolitischer Auseinandersetzungen. Allerdings wird das Altern als Prozess und das höhere Alter als Lebensphase in vielen dieser medizin- bzw. pflegeethischen und gesundheitspolitischen Debatten zumeist lediglich unter dem spezifischen Gesichtspunkt der jeweils erörterten Praktiken, Fragestellungen und Problemlagen thematisiert. Eine Betrachtung, die diese verschiedenen konkreten (...) Praxis- und Diskussionskontexte übergreift, das in ihnen jeweils vorausgesetzte Verständnis des Alter(n)s als solches thematisiert und in seiner Bedeutung für die ethische Fachdiskussion grundsätzlich reflektiert, findet dagegen kaum statt. Die Arbeitsgruppe „Altern und Ethik“ in der Akademie für Ethik in der Medizin soll zur Entwicklung einer solchen grundlegenderen und umfassenderen Betrachtungsweise beitragen. Der vorliegende Beitrag gibt einen ersten orientierenden Überblick über die zentralen Themenschwerpunkte, Problemstellungen und Kontroversen in den aktuellen medizin- bzw. pflegeethischen und gesundheitspolitischen Diskursen um das Alter(n) und markiert offene Fragen und Forschungsdesiderate. Wie sich dabei zeigt, kann eine eingehendere Auseinandersetzung mit dem Alter(n) nicht nur den einschlägigen alter(n)sbezogenen Fachdebatten zu fundierteren Perspektiven verhelfen, sondern auch der ethischen Diskussion insgesamt wichtige Impulse im Hinblick auf ihre anthropologischen Grundlagen und ihren normativen Bezugsrahmen vermitteln. (shrink)

A philosopher and a lawyer-economist examine the challenges of the last third of life. They write about friendship, sex, retirement communities, inheritance, poverty, and the depiction of aging women in films. These essays, or conversations, will help readers of all ages think about how to age well, or at least thoughtfully, and how to interact with older family members and friends.

While certain substantial moral dilemmas in health care have been given much attention, like abortion, euthanasia or gene testing, doctors rarely reflect on the moral implications of their daily clinical work. Yet, with its aim to help patients and relieve suffering, medicine is replete with moral decisions. In this qualitative study we analyse how doctors handle the moral aspects of everyday clinical practice. About one hundred consultations were observed, and interviews conducted with fifteen clinical doctors from different practices. It (...) turned out that the doctors’ approach to clinical cases followed a rather strict pattern across specialities, which implied transforming patients’ diverse concerns into specific medical questions through a process of ‘essentialising’: Doctors broke the patient’s story down, concretised the patient’s complaints and categorised the symptoms into a medical sense. Patients’ existential meanings were removed, and the focus placed on the patients’ functioning. By essentialising, doctors were able to handle a complex and ambiguous reality, and establish a medically relevant problem. However, the process involved a moral as well as a practical simplification. Overlooking existential meanings and focusing on purely functional aspects of patients was an integral part of clinical practice and not an individual flaw. The study thus questions the value of addressing doctors’ conscious moral evaluations. Yet doctors should be aware that their daily clinical work systematically emphasises beneficence at the expense of others—that might be more important to the patient. (shrink)

Globally, the population is ageing, which has serious consequences for businesses. The prosperity of companies is crucially dependent on the ability to effectively manage their employees, including older workers. Best practice in age management is defined as those measures that combat age barriers and/or promote age diversity. These measures may entail specific initiatives aimed at particular dimensions of age management; they may also include more general employment or human resources policies that help to create an environment in which individual employees (...) can achieve their potential without being disadvantaged by their age. Promoting early retirement is generally not encouraged. Companies now have to encourage longer working lives. Much needs to be done to ensure that work remains a positive experience for workers throughout their career trajectories, and it does not damage their health. It has been found by studies that health is significantly related to retirement timing, influences work performance, and health-related organisational policies can positively influence employee retention. The major contemporary challenges to health at work are those associated with the way work, and work organisations are designed and managed. This is especially true for older workers. A comprehensive and effective approach towards age management can be very beneficial for them. How should companies implement age management? Some possible ways are set out in this policy brief below, which focuses on best practices in age management regarding ergonomic aspects and health interventions for older workers at an organisational level. The intention is to discuss the current situation and to illustrate some organisational techniques in selected countries. This policy brief can serve as an inspiration for, among others, companies and policymakers. Recommendations for successful practice are included. In total, this policy brief covers 8 COST member countries to give a glimpse of the current situation of best practice in age management and show how companies in various states deal with ergonomic aspects, health interventions and the ageing of their labour force. (shrink)