Regulatory processes governing healthcare research have been very controversial within the academic and health sectors. We assume that it is generally accepted that there need to be institutional structures and systems to ensure researchers pursue ethical research in healthcare and that the chosen site can feasibly support the project in question. Having said that the efficiency and proportionality of ethics and research governance processes have frequently been called into question. This paper will examine some of the attempts made by the (...) National Institute for Health Research (NIHR) to streamline ethics approval as well as research and development processes. It will consider the extent to which the changes made by the NIHR have been successful, and then briefly consider the future direction of governance within healthcare research. (shrink)

Aim: Streamlining consent for low-risk comparative effectiveness research (CER) could facilitate research, while safeguarding patients' rights. Materials & methods: 2618 adults were randomized to one of seven consent approaches (six streamlined and one traditional) for a hypothetical, low-risk CER study. A survey measured understanding, voluntariness, and feelings of respect. Results: Participants in all arms had a high understanding of the trial and positive attitudes toward the consent interaction. Highest satisfaction was with a streamlined approach showing a video before the (...) medical appointment. Participants in streamlined were more likely to mistakenly think a signature was required. Conclusion: Streamlined consent was no less acceptable than traditional, signed consent. Streamlined and traditional approaches achieved similar levels of understanding, voluntariness and a feeling that the doctor–patient interaction was respectful. (shrink)

The U.S. review system for human subjects research has been widely criticized in recent years for requirements that delay research without improving human subjects protections. Any major reformulation of regulations may take some time to implement. In the meantime, current regulations often allow for streamlined ethics review without jeopardizing—and possibly improving—protections for research participants. We discuss underutilized options, including research that need not be classified as “human subjects research,” categories of studies that can be exempt from ethical review, and studies (...) that need only undergo expedited review by one IRB member. In addition, we consider ways to simplify review of multi-center research using one institution’s IRB. We speculate on multiple reasons for the underuse of these mechanisms, and exhort IRBs and researchers to take advantage of these important opportunities to improve the review process. (shrink)

Global health emergencies often lead to a proliferation of health-related research and resultant data, which is shared across borders to help control the outbreak of disease and support decision-making regarding public health interventions. However, efforts to share data can be hindered by diverse international ethical and legal frameworks. The frameworks aim to govern coordinated processing, sharing and transfer of health data across borders thus placing burdens on researchers who are willing or obligated to share data. In this paper, we investigate (...) ethical values and legal principles that can be applied to ensure a more streamlined approach in the governance of cross-border health data sharing during global health emergencies. A scoping review approach was used to better understand emerging evidence about issues related to the ethical and legal governance of cross-border health data sharing. We first highlight the challenges of sharing health data across borders. We then discuss how the challenges might be overcome through the application of ethical values and legal principles that have been identified in literature. This is followed by a proposal for possible ways of streamlining the governance of health data sharing from ethical and legal perspectives in a bid to better prepare for future global health emergencies and promote the responsible sharing of health data. (shrink)

The effort involved in the Evolution Project resembles design efforts in large, diverse organizations. In both cases, there are different languages, outlooks, vocabularies, expectations, objectives, and values. The Interactive Management (IM) methodology has been designed for just such situations. It has a tested record in management situations. We now have an opportunity to apply it to the Evolution Project. This article reports how IM was applied to proposed standards for the practice and ethics of design. It describes the IM methodology, (...) and indicates how this methodology can be used in the Evolution Project. Finally, it briefly reports some results in an area that dovetails with the Evolution Project. (shrink)

We argue that inductive analysis and operational assessment of the scientific process can be justifiably and fruitfully brought together, whereby the citation metrics used in the operational analysis can effectively track the inductive dynamics and measure the research efficiency. We specify the conditions for the use of such inductive streamlining, demonstrate it in the cases of high energy physics experimentation and phylogenetic research, and propose a test of the method’s applicability.

In the 1890s Ludwig Mach employed photography for visualizing streamlines in the emerging field of aerodynamic research. Étienne-Jules Marey developed a similar approach at the turn of the century. The two projects can be related to a number of current discussions on the history of scientific photography. The case of Ludwig Mach demonstrates how the collection of numerical data became both the subject and the challenge of a line of research intimately linked to the capacities of photography. At the end (...) of the nineteenth century, the particular potential of scientific photography is very often defined by comparison with the limited power of the human eye. In contrast, the example of streamline photography underlines that the requirements of the research context are critical for successfully employing photography. Marey’s studies point to a tension between his characterization of chronophotography as a method for analyzing the elementary units of processes in nature on the one hand and the necessary summation of single moments in time in his recordings of streamlines on the other. What Marey usually qualified as a cumbersome confusion was here the prerequisite of observation. The ’philosophy in machines’ ultimately limited the success of streamline photography; it aided in debates about qualitative matters, but could hardly provide what most interested scientists and engineers: reliable numbers. (shrink)

Electronic institutional review board systems (eIRBs) have become an integral component in ensuring compliance with Human Research Protection Program (HRPP) and IRB requirements. Despite this, few of these systems are configured to administer the single IRB (sIRB) process mandated by the National Institutes of Health (NIH) for multisite research. We interviewed 103 sIRB administrators, chairs, members, and staff members about their experiences with sIRB multisite research review. We observed three main obstacles to adapting existing eIRB systems to accommodate the sIRB (...) process: (1) Existing systems are not designed for sIRBs and are not configured to administer sIRB responsibilities, (2) they are not interoperable, and (3) resources to improve existing systems are lacking. Our findings suggest that IRBs that act as an sIRB will need major changes to their electronic systems in order to accommodate sIRB processes. These difficulties threaten both the ability of IRBs to focus on ethical rather than bureaucratic problems and the efficiency of multisite trials. (shrink)

In the half century since the formulation of the prokaryote : eukaryote dichotomy, many authors have proposed that the former evolved from something resembling the latter, in defiance of common (and possibly common sense) views. In such ‘eukaryotes first’ (EF) scenarios, the last universal common ancestor is imagined to have possessed significantly many of the complex characteristics of contemporary eukaryotes, as relics of an earlier ‘progenotic’ period or RNAworld. Bacteria and Archaea thus must have lost these complex features secondarily, through (...) ‘streamlining’. If the canonical three-domain tree in which Archaea and Eukarya are sisters is accepted, EF entails that Bacteria and Archaea are convergently prokaryotic.We ask what this means and how it might be tested. (shrink)

Here, a streamlined, scalable, laboratory approach is discussed that enables medium‐to‐large dataset analysis. The presented approach combines data management, artificial intelligence, containerization, cluster orchestration, and quality control in a unified analytic pipeline. The unique combination of these individual building blocks creates a new and powerful analysis approach that can readily be applied to medium‐to‐large datasets by researchers to accelerate the pace of research. The proposed framework is applied to a project that counts the number of plasmonic nanoparticles bound to peripheral (...) blood mononuclear cells in dark‐field microscopy images. By using the techniques presented in this article, the images are automatically processed overnight, without user interaction, streamlining the path from experiment to conclusions. (shrink)

This paper presents a streamlined taxonomy for categorizing offensive language in Arabic, specifically Modern Standard Arabic (MSA) and the Levantine dialect. Addressing a gap in the existing literature, which has mainly focused on Indo-European languages, our taxonomy divides offensive language into seven levels (six explicit and one implicit). We adapted our framework from the simplified offensive language (SOL) taxonomy by (Lewandowska-Tomaszczyk, Barbara, Slavko Žitnik, Anna Bączkowska, Chaya Liebeskind, Jelena Mitrovic & Giedre Valunaite Oleškeviciente. 2021a. Lod-connected offensive language ontology and tagset (...) enrichment. In Shubert R. Carvalho & Renato R. Souza (eds.), Proceedings of the workshops and tutorials held at ldk 2021 co-located with the 3rd language, data and knowledge conference, Vol. 3064, 135–150. CEUR Workshop Proceedings), customizing it to reflect the unique linguistic and cultural nuances of Arabic. To validate this taxonomy, we created a new dataset from various social media platforms, primarily focusing on Twitter. This dataset was manually curated by human annotators and is described in detail within the paper, serving as both a validation tool for our taxonomy and a foundation for future research on offensive language detection in Arabic. Initial analysis of the dataset reveals complex patterns of offensive expressions in MSA and Levantine Arabic, underscoring the need to account for linguistic and cultural variations in studying online abuse. Our taxonomy and dataset are vital for advancing research in Arabic sociocultural studies, natural language processing, and linguistic analysis, and contribute to the study of low-resource languages. (shrink)

This paper introduces a streamlined taxonomy for categorizing offensive language in Hebrew, addressing a gap in the literature that has, until now, largely focused on Indo-European languages. Our taxonomy divides offensive language into seven levels (six explicit and one implicit level). We based our work on the simplified offensive language (SOL) taxonomy introduced in (Lewandowska-Tomaszczyk et al. 2021a) hoping that our adjustment of SOL to the Hebrew language will be capable of reflecting the unique linguistic and cultural nuances of Hebrew. (...) The study involves both linguistic and cultural analysis beyond Natural Language Processing (NLP). We employed manual linguistic analysis to understand the nuances of offensive language in Hebrew. An accompanying dataset, gathered on Twitter and manually curated by human annotators, is described in detail. This dataset was constructed to both validate the taxonomy and serve as a foundation for future research on offensive language detection and analysis in Hebrew. Preliminary analysis of the dataset reveals intriguing patterns and distributions, underscoring the complexity and specificity of offensive expressions in the Hebrew language. The aim of our work is to capture the complexity and specificity of offensive expressions in Hebrew beyond what automated NLP methods alone can provide. Our findings highlight the significance of considering linguistic and cultural variations when researching and correcting abusive language online. We believe that our streamlined taxonomy and associated dataset will be crucial in improving research in Hebrew language sociocultural studies, natural language processing, and offensive language detection. Our study also makes a substantial contribution to the study of low-resource languages and can be used as a model for future research on other languages. (shrink)

After a streamlined confrontation of husserl's phenomenology and sartre's existentialism, this paper affirms their compatibility, denies their necessary connection, pleads for their cooperation and criticizes sartre's rejection of husserl's phenomenology of the pure ego.

Semi-intuitionistic logic is the logic counterpart to semi-Heyting algebras, which were defined by H. P. Sankappanavar as a generalization of Heyting algebras. We present a new, more streamlined set of axioms for semi-intuitionistic logic, which we prove translationally equivalent to the original one. We then study some formulas that define a semi-Heyting implication, and specialize this study to the case in which the formulas use only the lattice operators and the intuitionistic implication. We prove then that all the logics thus (...) obtained are equivalent to intuitionistic logic, and give their Kripke semantics. (shrink)

One of the fundamental ethical concerns about biomedical research is that it frequently exposes participants to risks for the benefit of others. To protect participants’ rights and interests in this context, research regulations and guidelines set out a mix of substantive and procedural requirements for research involving humans. Risk thresholds play an important role in formulating both types of requirements. First, risk thresholds serve to set upper risk limits in certain types of research. Second, risk thresholds serve to demarcate risk (...) categories that streamline risk-adapted systems of ethical oversight. But although risk thresholds play such an important role in research governance, there is a need both to better define the existing risk thresholds and to delineate new thresholds in order to develop more risk-adapted systems of research oversight. The present paper examines the existing minimal risk threshold and the surrounding debates with the goal of deriving a systematic approach to setting thresholds of research risk. (shrink)

Climate change fingerprint studies investigate the causes of recent climate change. I argue that these studies have much in common with Steel’s (2008) streamlined comparative process tracing, illustrating a mechanisms-based approach to extrapolation in which the mechanisms of interest are simulated rather than physically instantiated. I then explain why robustness and variety-of-evidence considerations turn out to be important for understanding the evidential value of climate change fingerprint studies.

Once a term used primarily by moral philosophers, “moral distress” is increasingly used by health professionals to name experiences of frustration and failure in fulfilling moral obligations inherent to their fiduciary relationship with the public. Although such challenges have always been present, as has discord regarding the right thing to do in particular situations, there is a radical change in the degree and intensity of moral distress being expressed. Has the plight of professionals in healthcare practice changed? “Plight” encompasses not (...) only the act of pledging, but that of predicament and peril. The author claims that health professionals are increasingly put in peril by healthcare reform that undermines their efficacy and jeopardizes ethical engagement with those in their care. The re-engineering of healthcare to give precedence to corporate and commercial values and strategies of commodification, service rationing, streamlining, and measuring of “efficiency,” is literally demoralizing health professionals. Healthcare practice needs to be grounded in a capacity for compassion and empathy, as is evident in standards of practice and codes of ethics, and in the understanding of what it means to be a professional. Such grounding allows for humane response to the availability of unprecedented advances in biotechnological treatments, for genuine dialogue and the raising of difficult, necessary ethical questions, and for the mutual support of health professionals themselves. If healthcare environments are not understood as moral communities but rather as simulated marketplaces, then health professionals’ moral agency is diminished and their vulnerability to moral distress is exacerbated. Research in moral distress and relational ethics is used to support this claim. (shrink)

We present a streamlined axiom system of special relativity in first-order logic. From this axiom system we "derive" an axiom system of general relativity in two natural steps. We will also see how the axioms of special relativity transform into those of general relativity. This way we hope to make general relativity more accessible for the non-specialist.

A new calculus, based upon the multivector derivative, is developed for Lagrangian mechanics and field theory, providing streamlined and rigorous derivations of the Euler-Lagrange equations. A more general form of Noether's theorem is found which is appropriate to both discrete and continuous symmetries. This is used to find the conjugate currents of the Dirac theory, where it improves on techniques previously used for analyses of local observables. General formulas for the canonical stress-energy and angular-momentum tensors are derived, with spinors and (...) vectors treated in a unified way. It is demonstrated that the antisymmetric terms in the stress-energy tensor are crucial to the correct treatment of angular momentum. The multivector derivative is extended to provide a functional calculus for linear functions which is more compact and more powerful than previous formalisms. This is demonstrated in a reformulation of the functional derivative with respect to the metric, which is then used to recover the full canonical stress-energy tensor. Unlike conventional formalisms, which result in a symmetric stress-energy tensor, our reformulation retains the potentially important antisymmetric contribution. (shrink)

The structuring of our environment to provide cues and reminders for ourselves is common: We leave notes on the fridge, we have a particular place for our keys where we deposit them, making them easy to find. We alter our world to streamline our cognitive tasks. But how did hominins gain this capacity? What pushed our ancestors to structure their physical environment in ways that buffered thinking and began the process of using the world cognitively? I argue that the capacity (...) to engage in these behaviours is a by-product of increased tool investment and tool curation, which in turn was necessary because of increasingly heterogeneous environments. The minute tools are carried and cared for, they begin to undergo selection for added functions, becoming available as cognitive primers and as signals. I explore the trajectory of this co-evolutionary feedback loop of hominins and their tools, and demonstrate the role tools have in shaping our thinking. (shrink)

We investigate maximal free sequences in the Boolean algebra \ {/}\text {fin}\), as defined by Monk :593–610, 2011). We provide some information on the general structure of these objects and we are particularly interested in the minimal cardinality of a free sequence, a cardinal characteristic of the continuum denoted \. Answering a question of Monk, we demonstrate the consistency of \. In fact, this consistency is demonstrated in the model of Shelah for \ :433–443, 1992). Our paper provides a streamlined (...) and mostly self contained presentation of this construction. (shrink)

BackgroundHIV prevention research in resource-limited countries is associated with a variety of ethical dilemmas. Key amongst these is the question of what constitutes an appropriate standard of health care (SoC) for participants in HIV prevention trials. This paper describes a community-focused approach to develop a locally-appropriate SoC in the context of a phase III vaginal microbicide trial in Mwanza City, northwest Tanzania.MethodsA mobile community-based sexual and reproductive health service for women working as informal food vendors or in traditional and modern (...) bars, restaurants, hotels and guesthouses has been established in 10 city wards. Wards were divided into geographical clusters and community representatives elected at cluster and ward level. A city-level Community Advisory Committee (CAC) with representatives from each ward has been established. Workshops and community meetings at ward and city-level have explored project-related concerns using tools adapted from participatory learning and action techniques e.g. chapati diagrams, pair-wise ranking. Secondary stakeholders representing local public-sector and non-governmental health and social care providers have formed a trial Stakeholders' Advisory Group (SAG), which includes two CAC representatives.ResultsKey recommendations from participatory community workshops, CAC and SAG meetings conducted in the first year of the trial relate to the quality and range of clinic services provided at study clinics as well as broader standard of care issues. Recommendations have included streamlining clinic services to reduce waiting times, expanding services to include the children and spouses of participants and providing care for common local conditions such as malaria. Participants, community representatives and stakeholders felt there was an ethical obligation to ensure effective access to antiretroviral drugs and to provide supportive community-based care for women identified as HIV positive during the trial. This obligation includes ensuring sustainable, post-trial access to these services. Post-trial access to an effective vaginal microbicide was also felt to be a moral imperative.ConclusionParticipatory methodologies enabled effective partnerships between researchers, participant representatives and community stakeholders to be developed and facilitated local dialogue and consensus on what constitutes a locally-appropriate standard of care in the context of a vaginal microbicide trial in this setting.Trial registrationCurrent Controlled Trials ISRCTN64716212. (shrink)

A general result is proved about the existence of maximally consistent theories satisfying prescribed closure conditions. The principle is then used to give streamlined proofs of completeness and omitting-types theorems, in which inductive Henkin-style constructions are replaced by a demonstration that a certain theory respects a certain class of inference rules.

Background: Using the power of Internet, crowdfunding platforms are currently changing the traditional landscape of fundraising. Social media-based IT platforms in particular are bringing the creators of crowdfunding projects closer than ever to potential investors. A large variety of factors function as determinants of individuals' intention to participate in crowdfunding and have an intertwined impact on funding as the ultimate project goal.Objectives: For a better understanding of investor behavior in social media-based crowdfunding projects, this paper covers identifying, analyzing, and classifying (...) general and specific factors of investor motivation, based on the literature in the field.The main focus is the relationship between the affordances provided by social media-based crowdfunding platforms and the psychological determinants of investor motivation in innovative start-up projects.Methods: Using IEEE Explore, Clarivate Web of Science, ScienceDirect, and Scopus, we conducted a systematic review of the existing research on the emerging role of crowdfunding as a disruptive technology in financing the start-up innovative projects. The paper explores the main determinants of investor motivation and aims to streamline the success factors in crowdfunding campaigns.Results: A total of 1,216 publications were identified after searching the aforementioned databases and, upon refining the results, 515 articles were considered for the final sample. After reading the titles and abstracts, the sample was reduced to 78 articles that were read in-depth and synthesized in accordance with the defined research questions. The selected articles were clustered into three main categories: general studies, determinants of investor behavior, and success factors.Conclusions: In the new global economy, crowdfunding platforms have become the nexus between the emerging creators of innovative products and services and the necessary funding sources. This connection is possible via a cumulative collection of contributions from multiple investors recruited from the audience of the selected platform, without time or space constraints. However, the determinants of the investment decision are very different in the case of social media-based crowdfunding platforms compared to determinants in the mainstream environment. This paper surveys these motivators and reveals how platform features can be used to persuade individuals to make a financial contribution toward the success of a project. (shrink)

In 2000, US Secretary of Health and Human Services Secretary Tommy Thompson mobilized the US public health infrastructure to deal with escalating trends of excess body weight. A cornerstone of this effort was a report entitled The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity. The report stimulated a great deal of public discussion by utilizing the distinctive public health terminology of an epidemic to describe the growing prevalence of obesity in the US population. We suggest (...) that the ensuing controversy was fueled in part by the report's ambiguous usage of the evocative term “epidemic.” In some passages, the report seems to use “epidemic” in a literal sense, suggesting that rising prevalence of excess body weight should be defined technically as a disease outbreak. Other passages of the report present the same key term metaphorically, leaving readers with the impression that the epidemic language is invoked primarily for rhetorical effect. Here, we explore dynamics and implications of both interpretations. This analysis sheds light on the ongoing public argument about the appropriate societal response to steadily increasing body sizes in the US population; likewise, it capitalizes on the accumulated knowledge that the field of public health has garnered from combating diverse historic epidemics. Our interdisciplinary approach deploys critical tools from the fields of rhetoric, sociology and epidemiology. In particular, we draw from metaphor theory and public address scholarship to elucidate how the Call to Action frames public deliberation on obesity. We turn to the applied public health literature to develop a reading of the report that suggests a novel approach to the problem—application of the Epidemic Investigation protocol to streamline the public health response and reframe the public argument about obesity. (shrink)

BackgroundResearch has been an essential part of the COVID-19 pandemic response, including in Latin American (LA) countries. However, implementing research in emergency settings poses the challenge of producing valuable knowledge rapidly while upholding research ethical standards. Research ethics committees (RECs) therefore must conduct timely and rigorous ethics reviews and oversight of COVID-19 research. In the LA region, there is limited knowledge on how countries have responded to this need. To address this gap, the objective of our project is to explore (...) if LA countries developed policies to streamline ethics review and oversight of research in response to the pandemic while ensuring its adherence to ethical standards, and to analyze to what extent these governance frameworks are in accordance with international guidance.MethodsWe conducted a descriptive and exploratory study assessing the COVID-19 research ethics governance frameworks of 19 LA countries, considering 4 dimensions based on international COVID-19 ethics guidance documents: (i) ethics review organizational model adopted, (ii) measures to coordinate between RECs and other research stakeholders, (iii) operational guidance for RECs, and (iv) key ethical issues for review and oversight of COVID-19 research.Results10 out of 19 LA countries have some policy to streamline ethics review of COVID-19 research. Of these countries only 6 issued comprehensive documents following international guidance that contemplate strategies with recommendations for concrete actions for a timely and rigorous review.ConclusionLA countries adopted partial strategies and operational guidance that may demonstrate a lack of a comprehensive view of research ethics for the review and oversight of COVID-19 research. Continuing efforts should be directed to strengthen LA countries' research capacity to respond timely and ethically to future health emergencies. Past lessons and the ones from this pandemic should be the basis to develop international standards and operational guidelines for ethics review and oversight of any research for public health emergencies. (shrink)

"The overall aim of this book is to understand the character of moral progress, so that making moral progress may become more systematic and secure, less chancy and less bloody. Drawing on three historical examples - the abolition of chattel slavery, the expansion of opportunities for women, and the increasing acceptance of same-sex love - it asks how those changes were brought about, and seeks a methodology for streamlining the kinds of developments that occurred. Moral progress is conceived as (...) pragmatic progress, progress from rather than progress to, achieved by overcoming the problems and limits of the current situation. Two kinds of problems are distinguished: problems of exclusion, found when the complaints of some people are ignored; and problems of false consciousness, present when the oppressed adopt judgments from the ambient society and do not protest their condition. The proposed methodology advocates procedures for listening to voiced complaints and for systematically reviewing the way in which particular self-conceptions, ideals and identities are taken to be appropriate for various groups of people. Through outlining a picture of moral practice, at both the individual and the societal levels, the book seeks to orient moral philosophy away from metaethical questions of realism and towards moral methodology"--. (shrink)

Background: Centralization of IRB reviews have been increasing in the US and elsewhere, but many questions about it remain. In the US, a few centralized IRBs (CIRBs) have been established, but how they do and could operate remain unclear. Methods: I contacted 60 IRBs (every fourth one in the list of the top 240 institutions by NIH funding), and interviewed leaders from 34 (response rate = 55%) and an additional 12 members and administrators. Results: These interviewees had often interacted with (...) CIRBs, but supported local reviews, and offered advantages and disadvantages of each. Interviewees argued that local IRBs can provide "local knowledge" of subjects and PIs, and "curbside consults" with PIs, facilitating mutual trust. PIs may interact more fully and informally, and hence effectively with local IRBs. IRBs also felt additional responsibility to protect "their own" subjects. Respondents mentioned a few advantages of CIRBs (e.g., CIRBs may streamline reviews), though far more rarely and cursorily. Overall, interviewees were wary of CIRBs, which they saw as varying widely in quality, depending on who happened to be members. Both local and centralized IRBs appear to have unintended consequences. For instance, discrepancies arose between IRBs that appeared to reflect differences in institutional culture and history, and personalities of chairs and/or vocal members, more than in local community values per se, and thus do not seem to be the intent of the regulations. While some critics see CIRBs as solutions to many IRB problems, critical tradeoffs and uncertainties emerge. Conclusions: These data have critical implications for future policy and research. Debates need to evolve beyond simply a binary discussion of whether CIRBs should replace local IRBs, to examine how and to what degree different models might operate, and what the relative advantages and disadvantages of each are. While some critics see CIRBs as panaceas, certain problems appear likely to continue. Careful consideration needs to be given to whether the advantages of local IRBs outweigh the problems that result, and whether a system can be developed that provides these benefits, while avoiding the disadvantages of local IRBs. (shrink)

Parts I through III of this paper will examine several, increasingly comprehensive forms of aggregation, ranging from insurance reimbursement “lock-in” programs to PDMPs to completely unified electronic medical records. Each part will advocate for the adoption of these aggregation systems and provide suggestions for effective implementation in the fight against opioid misuse. All PDMPs are not made equal, however, and Part II will, therefore, focus on several elements — mandating prescriber usage, streamlining the user interface, ensuring timely data uploads, (...) creating a national data repository, mitigating privacy concerns, and training doctors on how to respond to perceived doctor-shopping — that can make these systems more effective. In each part, we will also discuss the privacy concerns of aggregating data, ranging from minimal to significant, and highlight the unique role of stigma in motivating these concerns. In Part IV, we will conclude by suggesting remedial steps to offset this loss of privacy and to combat the stigma around SUDs and mental health disorders in general. (shrink)

There are a host of data privacy decisions we must make every day – and it is exceedingly difficult, if not impossible, for us to make meaningful decisions about all of them. In this thesis, I define, conceptualize, interrogate, and design for value-centered privacy decision making – that is, decisions that are focused on who we are and what we value – as a means of respecting and promoting user autonomy. To achieve this, this work utilizes philosophical theory to understand (...) value-centered privacy decisions and translates this theory into a system that promotes such decisions. In summary, this work has two major contributions. Firstly, I conceptualize and define value-centered privacy decision-making using a value-centered theory of autonomy. I explore how we can create the space for value-centered privacy decisions by applying the Four-Dimensional Theory of Self Governance (4DT). I first conceptualize privacy decisions in terms of these four dimensions – self-definition, self-realization, self-unification, and self-constitution – and explore existing data privacy challenges through this lens. In particular, I conceptualize notice fatigue in terms self-realization, self-unification, and self-constitution; a lack of relevant privacy controls in terms of self-realization and self-unification; and nudges in terms of self-realization and self-unification. I then present and discuss results from a mixed-methods investigation into how values are involved in privacy decisions – in particular, app choice. We found that they were related in a highly individualized, context specific manner, observing different values that were more relevant based on the app in question. This suggests that the value-privacy relationship is largely informed by individual preferences and understandings of values. However, the values of Use, Control, and Community were quite prevalent, with Use and Control in particular spanning contexts and individual participants. They were also frequently perceived as in conflict with each other. This suggests that these three values are the most relevant to consider when designing for value-centered privacy decisions. The participants’ experiences can also be explained using 4DT, providing empirical support for our conceptualization of value centered privacy. However, the study results also provide insights into how existing systems – such as surveillance capitalism and the attention economy – frustrate value centered privacy decisions. Secondly, I use the 4DT-based understanding of value-centered privacy decisions to establish the usability and effectiveness of the value-centered approach, designing a privacy assistant to help users make app choices that are in more accordance with their personal values. To inform the design of a smartphone assistant that creates this space for users, I examine an existing technology – personalized privacy assistants (PPAs) – using the 4DT lens. Using insights from this examination, I propose a value-centered, smartphone privacy assistant (VcPA) to help users make more value-centered decisions at one privacy decision point: smartphone app choices. This VcPA consists of three features: selective notices, exploratory notices, and a “suggest alternative apps” feature. I then present the results from testing a prototype VcPA system with users, serving as a proof-of concept that a value-centered privacy assistant, designed using privacy preferences and values, could help users when making privacy decisions such as choosing apps. In particular, we found that the VcPA prototype helped users download value-consistent apps, with the “suggest alternatives” feature especially well-received. We also identified places where the VcPA could be improved – for example, profiles could be improved by being made more customizable; VcPA notices could be made easier to understand; and the “suggest alternatives” feature could be more streamlined. This thesis lays the groundwork for future researchers to design systems that promote value-centered privacy decisions. To guide this future work, I lastly present prospective research avenues to advance the value-centered approach to data privacy decision-making. In particular, I discuss limitations of the studies in this work, including engagement with a wider range of demographic groups; touch upon how the identified VcPA improvements, such as improved VcPA profiles, might be accomplished; briefly explore the possibility of applying the value-centered understanding to other privacy contexts; and consider how both system-wide regulation and individual autonomy enhancing interventions, such as the VcPA, can empower us to shape a technological future based on our values. (shrink)

This book represents a unique endeavor to elucidate the story of Kosovo's unilateral quest for statehood. It is an inquiry into the international legal aspects and processes that shaped and surrounded the creation of the state of Kosovo. Being created outside the post-colonial context, Kosovo offers a unique yet controversial example of state emergence both in the theory and practice of creation of states. Accordingly, the book investigates the legal pathways, strategies, developments and policy positions of international agencies/actors and regional (...) players (in particular the EU) that helped Kosovo to establish its independence and gradually acquire statehood. Although contested, Kosovo, and its quest for statehood, represents a unique example of successful unilateral secession. The book therefore explores and analyses patterns of state formation and nation-building in Kosovo, and its transition to democracy. It presents a three-level assessment. First, seen from a historical perspective, the book examines the validity of the right of Kosovar-Albanians to self-determination and remedial secession. Second, from a legal positivist perspective, it scrutinizes all of the legalist arguments that support Kosovo's right to statehood, and claims that both traditional and legality-based criteria for statehood remain insufficient to determine whether Kosovo has achieved statehood. Third, from a post-factum perspective, the book analyzes the scope and extent to which the internationally blended element was decisive in Kosovo's state-formation and state-building processes. It explains how the EU's involvement as an 'internationally blended element' in Kosovo's efforts to achieve statehood was instrumental and played a crucial role in shaping the emerging state. In particular, the book elaborates on how the EU was able to streamline its mode of intervention in the context of state-building and reform. (shrink)

The Curia dei Foretani, or the Court of the Countrymen, of the commune of Lucca was a sort of rural small-claims court. Designed by an urban government to hear minor civil cases which originated in the countryside, it was occupied with the variety of issues that punctuated country life, most especially cases brought by landlords, merchants, and speculators whose living was tied to the rural economy of northwestern Tuscany. The records of the Curia dei Foretani offer an unusual opportunity to (...) investigate landlord-tenant, lender-borrower, and speculator-producer relations during the critical period of the fourteenth century when urban interest in the countryside was intense. As will become clear, the streamlined procedure used by the court was designed to allow rapid petition, hearing, and judgment, which, it has been argued, were designed to favor the wealthy, usually urban, elites. Yet as analysis of the actual functioning of the court will show, villagers in this part of Tuscany were able to avoid, or at least moderate, the most complete forms of landlord domination. The reasons why are complex, but one aspect was the court procedure itself, which could be manipulated by knowledgeable members of strong, semi-autonomous rural communities who had access to legal advice or who had broadly based communal support for their actions. Urban landlords in the Lucchesia never achieved the sort of economic domination of rural life which seems to have typified the region around Florence and Siena. (shrink)

A subcommittee of the American Association of University Professors has published a report, “Research on Human Subjects: Academic Freedom and the Institutional Review Board” , which argues that institutional review board oversight may pose a threat to academic freedom, and that a different oversight model based on departmental review would both maintain subject protection and eliminate the threat. But the report does not demonstrate that IRBs pose a threat to academic freedom, and using departmental oversight may not sufficiently protect human (...) subjects of research, could introduce other problems, and would itself pose threats to academic freedom. Instead, some alternative methods of streamlining IRB oversight for certain types of research would better address the practical problems currently encountered. (shrink)

Rapid advances and exponential growth in computer and telecommunications technology have taken individual records and papers revealing the most intimate details of one’s life, habits, and genetic predisposition from the private sector into the public arena in derogation of privacy considerations. Although computerized medical information offers a means of streamlining and improving the health care delivery system through speed and enormous storage capacity, it also presents new challenges as it affects the right of privacy and expectation of confidentiality, creating (...) serious ethical and legal issues. Other considerations include constitutional matters such as loss of liberty when one is compelled to remain in an undesirable or unsuitable job so that insurance will not be canceled or the inability to secure another more suitable position due to genetic predisposition and denial of equal protection of the laws if one is stigmatized because one belongs to a certain ethnic or racial group that exhibits a particular genetic propensity. Collateral questions concern the propriety of disclosure of confidential health care information, including genetic data. This article also considers the proposed federal guidelines for a health information privacy law. (shrink)

Now available from Rowman & Littlefield, the third edition of this introductory critical thinking text features streamlined chapters, Think for Yourself activities, and a complete glossary of critical thinking terms.

This paper employs the ideas of geometric algebra to investigate the physical content of Dirac's electron theory. The basis is Hestenes' discovery of the geometric significance of the Dirac spinor, which now represents a Lorentz transformation in spacetime. This transformation specifies a definite velocity, which might be interpreted as that of a real electron. Taken literally, this velocity yields predictions of tunnelling times through potential barriers, and defines streamlines in spacetime that would correspond to electron paths. We also present a (...) general, first-order diffraction theory for electromagnetic and Dirac waves. We conclude with a critical appraisal of the Dirac theory. (shrink)

Two EPR arguments are reviewed, for their own sake, and for the purpose of clarifying the status of "stochastic" hidden variables. The first is a streamlined version of the EPR argument for the incompleteness of quantum mechanics. The role of an anti-instrumentalist ("realist") interpretation of certain probability statements is emphasized. The second traces out one horn of a central foundational dilemma, the collapse dilemma; complex modal reasoning, similar to the original EPR, is used to derive determinateness (of all spin components (...) of two spin- 1 / 2 particles in the singlet state) from just (a form of) weak locality, result definiteness, and an assumption on propensities based on conservation. Theories meeting these conditions are therefore constrained by the Bell inequalities. Neither controversial assumptions of "strong locality" ("factorability") nor of determinism are employed in the derivation. The categories of "stochastic hidden variables" are then analyzed; one can focus on "quasi-definite" theories, without loss of generality. A means of excluding these is proposed, based on a demand that certain ideal cases be accurately treated. Theorems from quantum measurement theory, sometimes cited as showing that such cases are not physically possible, are found inapplicable. (shrink)

Islamic equity funds are subject to the screening criteria for stock selection imposed by the principles of Islamic jurisprudence. Equities must pass three basic screens: revenue source, business activity, and financial factors to be included in an Islamic fund. However, screening criteria are not universal especially for the financial factors. One can use financial ratios based on either the book-value of total assets or the market-value of equity for screening of stocks. This may not only result in a different portfolio (...) composition but also entail diverse rebalancing and monitoring costs. The performance of 29 Islamic equity indices versus conventional indices from four major international index providers using different Shari’ah screening criteria are analyzed in a single as well as in a multi-equation framework. The use of a multi-equation framework has the added advantage of utilizing the information content of different screening criteria adopted by different index providers. The empirical findings suggest that the difference in screening criteria does not significantly affect the performance of IEIs. Returns deviation, if any, stems from the relative riskiness of the IEI as compared with the relevant benchmark. Work needs to done to streamline the quantitative screening criteria to avoid confusion among the investing public. (shrink)

The Malaysian government recognises the potential contribution of biotechnology to the national economy. However, ongoing controversy persists regarding its ethical status and no specific ethical guidelines have been published relating to its use. In developing such guidelines, it is important to identify the underlying principles that are acceptable to Malaysian society. This paper discusses the process of determining relevant secular and Islamic ethical principles and establishing their similarities before harmonising them. To achieve this, a series of focus group discussions were (...) conducted with 23 knowledge experts representing various stakeholders in the biotechnology community. Notably, several principles between the secular and Islamic perspectives are indirectly or directly similar. All the experts agreed with the predominant six ethical principles of secular and Islamic philosophy and their importance and relevance in modern biotechnology. These are beneficence and non-maleficence as the main or overarching principles, the preservation of religious and moral values, the preservation of the intellect and the mind, the protection of human safety, the protection of future generations, and protection of the environment and biological diversity. Several adjustments were made to the terminologies and definitions of these six principles to formulate acceptable guiding principles for the ethics of modern biotechnology in Malaysia. These can then be adopted as core values to underpin future national guidelines on modern biotechnology ethics. These principles will be particularly important in guiding the policy makers, enforcers, industries and researchers to streamline their activities. In so doing, modern biotechnology and its products can be properly managed without jeopardising the interests of the Muslim community as well as the general public. Importantly, they are expansive and inclusive enough to embrace the religious sensitivity of diverse quarters of Malaysia. (shrink)

Logical frameworks for analysing the dynamics of information processing abound [4, 5, 8, 10, 12, 14, 20, 22]. Some of these frameworks focus on the dynamics of the interpretation process, some on the dynamics of the process of drawing inferences, and some do both of these. Formalisms galore, so it is felt that some conceptual streamlining would pay off.This paper is part of a larger scale enterprise to pursue the obvious parallel between information processing and imperative programming. We demonstrate (...) that logical tools from theoretical computer science are relevant for the logic of information flow. More specifically, we show that the perspective of Hoare logic [13, 18] can fruitfully be applied to the conceptual simplification of information flow logics. (shrink)

Between about 2,600 and 2,400 years ago, a group of men lived whose thought formed the beginning of the discipline of philosophy. All contemporary material records of these men have disappeared, with the possible exception of a piece of a statue and some likenesses on early coins and vases. The very notion that these philosophers can be best understood as Presocratics is redolent with interpretative interventions. Although this view is not without ancient precedents, the driving force behind its dominance in (...) the twentieth century was the great achievement of the German classical scholar Hermann Diels, which exercises authority to this day. The aim of this article is to examine the sources for Presocratic philosophy. It commences with the dominant legacy of Diels. Thereafter, it examines various strands of transmission streamlined by Diels. Finally, it reaches some tentative conclusions on what should be the way forward in future research. (shrink)

Recent years have featured a leap in academic and public interest in Corporate Social Responsibility (CSR) activities and related corporate reporting. Two main themes in this literature are the exploration of management incentives to engage in and disclose this information, and of the use and value of this information to market participants. We extend the second theme by examining the interest that specific investor classes have in the use of CSR information. We rely on feminist intersectionality, which suggests that gender (...) intersects with other identities to yield different values, experiences, and opportunities that can lead to gender-based preferences for CSR information. Based upon a survey of 750 US-based retail investors, we find that female retail investors have a greater interest in the use of CSR information, relative to male retail investors. Women express greater anticipated future demand for this information than do men. Further, the magnitude of the increase from current use to anticipated future demand is greater for women than men. Age is a significant modifying factor in that the discrepancy between women of any age and older men is greater than that between women and younger men. Finally, women also exhibit greater demand for streamlining of the information flow, consistent with pressures induced by time poverty. It appears that current disclosure practices provide a less than optimal match with the needs of the information consumers that are primarily interested in using this information. This mismatch may result in a systematic disenfranchisement of female investing classes which suggests an ethical need to level the playing field. (shrink)