The neoliberal-inspired “shock therapy” policies were designed to allow efficiency considerations to shape the new capitalist economies. Most experts theorized that these policies would enable postcommunist countries to close the gap with the West. After more than a decade, this prediction has been falsified. Fieldwork in 25 Russian firms demonstrates that the neoliberal prescription of mass privatization creates shocks that make successful enterprise restructuring almost impossible. Instead, most firms lower their technological level of production and retreat to nonmarket (...) activity to survive. The result is a poorer economy with less growth potential and thus increased divergence with the West. (shrink)

This paper explores the relationship between psychology and neurobiology in the context of cognitive science. Are the sciences that constitute cognitive science independent and theoretically autonomous, or is there a necessary interaction between them? I explore Fodor's Multiple Realization Thesis (MRT) which starts with the fact of multiple realization and purports to derive the theoretical autonomy of special sciences (such as psychology) from structural sciences (such as neurobiology). After laying out the MRT, it is shown that, on closer inspection, the (...) argument is either circular or self-undermining--the argument either assumes the very autonomy it seeks to demonstrate or the concluded autonomy is contradicted by the theoretical interdependence invoked by the premises of the argument. Next, I explore a concrete example of multiple realization in the explanation of animal behavior: the convergent evolution of jamming avoidance behaviors in three genera of weakly electric fish. Contrary to the image painted by the MRT, the work on these animals involves a high degree of interaction between the various levels of investigation. The fact that our understanding of electric fish behavior involves functional theories and multiple realization without the kind of disunified science that is supposed to follow from such a situation indicates that the mere fact of multiple realization cannot be the basis for an autonomous psychology. (shrink)

The heat shock genes (hsp genes) are a family of truly ubiquitous genes which have been highly conserved throughout evolution. The protein products of these genes, the heat shock proteins (hsps) are thought to play a protective role in cells (although this may not be their only function). The genes and their products have been the subjects of intense research both at the cellular and molecular levels over the past few years. This review deals with the conservation of (...) the heat shock response and with the expression of the hsp genes under different conditions: they are usually activated as a group by different forms of stress, but can be expressed individually or in subsets at different stages during normal development and the expression of one of them is evoked by the products of different transforming genes. Experimental approaches which have provided information or which have led to hypotheses regarding the molecular details of the mechanisms regulating the expression of the genes are discussed. (shrink)

Self‐renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chaperones and co‐chaperones, especially heat shock proteins (Hsp), are ubiquitous molecules involved in the modulation of protein conformational and complexation states. The function of Hsp, which are typically associated with stress response and tolerance, is well characterized in differentiated cells, while their role in stem cells remains unclear. It appears that embryonic stem cells exhibit increased stress tolerance and concomitant high levels of (...) chaperone expression. This review critically evaluates stem cell research from a molecular chaperone perspective. Furthermore, we propose a model of chaperone‐modulated self‐renewal in mouse embryonic stem cells. (shrink)

Anxiety and stress-related disorders constitute a large global health burden, but are still poorly understood. Prior work has demonstrated clear impacts of stress upon basic cognitive function: biasing attention toward unexpected and potentially threatening information and instantiating a negative affective bias. However, the impact that these changes have on higher-order, executive, decision-making processes is unclear. In this study, we examined the impact of a translational within-subjects stress induction (threat of unpredictable shock) on two well-established executive decision-making biases: the framing (...) effect ( N = 83), and temporal discounting ( N = 36). In both studies, we demonstrate (a) clear subjective effects of stress, and (b) clear executive decision-making biases but (c) no impact of stress on these decision-making biases. Indeed, Bayes factor analyses confirmed substantial preference for decision-making models that did not include stress. We posit that while stress may induce subjective mood change and alter low-level perceptual and action processes ( Robinson et al., 2013c ), some higher-level executive processes remain unperturbed by these impacts. As such, although stress can induce a transient affective biases and altered mood, these need not result in poor financial decision-making. (shrink)

Social and environmental shocks associated with freshwater management are inherently tied with the lives and well-being of all global citizens. Thus, exploring key actors’ roles is a critical element of this grand challenge. Utilizing an inductive multiple case study, we explore sustainability leadership and subsequent organizational perspective-taking behaviours initiated by actors within freshwater management in response to the grand challenge. A vibrant inductive model elicited three main themes: identifying conditions for organizational perspective-taking, modifying organizational frames of reference and emergence of (...) multi-level influence. The discussion extracts critical insights for sustainability leadership and highlights complexities involved in facilitating effective decision-making among diverse actors. Fundamentally, this article contributes a distinct multi-level systems framework for sustainability leadership drawing from social–ecological systems theory and organizational resilience. We conclude by offering future research opportunities within sustainability leadership designed to bridge the gap between grand challenges and our abilities to solve them. (shrink)

An increasing number of environmentally knowledgeable observers and activists comprehend the situation faced by the emerging global civilization and its unsustainable systems, characterized by planet‐altering positive feedback loops arising from human activity. They perceive contemporary natural and cultural developments as the prelude to the imminent collapse of technological civilization and the cataclysmic end of the Anthropocene epoch via a forced passage through the population bottleneck of the impending extinction‐level event which only a remnant of the present biosphere is likely (...) to survive. Should this understanding be accurate, our own time could become the occasion for the greatest choice ever made on Earth: whether to continue things as they are until humanity becomes the chief cause and the chief victim of the now‐unfolding mass extinction; or to make the necessary transition to the awakening of Planet Earth. (shrink)

An increasing number of environmentally knowledgeable observers and activists comprehend the situation faced by the emerging global civilization and its unsustainable systems, characterized by planet‐altering positive feedback loops arising from human activity. They perceive contemporary natural and cultural developments as the prelude to the imminent collapse of technological civilization and the cataclysmic end of the Anthropocene epoch via a forced passage through the population bottleneck of the impending extinction‐level event which only a remnant of the present biosphere is likely (...) to survive. Should this understanding be accurate, our own time could become the occasion for the greatest choice ever made on Earth: whether to continue things as they are until humanity becomes the chief cause and the chief victim of the now‐unfolding mass extinction; or to make the necessary transition to the awakening of Planet Earth. (shrink)

Building on 42 semi-structured interviews with directors and stakeholders of food charities based in Greater Manchester (UK), alongside online data and Factiva references trends, I argue that the charitable food provision (CFP) sector can be effectively conceptualized as a strategic action field (SAF). To do so, I first focus on the shared rules, understandings and practices characterising the organizations that belong to the field and on the broader field environment that imposes constraints and provides opportunities to the field actors. Subsequently, (...) I examine the characteristics of five particularly relevant charities to describe the social positions and position-takings of the incumbent, the challengers and the group I refer to as sideliners of the field. Hence, I briefly touch upon the Covid-19 outbreak as an exogenous shock to discuss the effect of the campaign carried out by a ‘socially skilled actor’ - football player Marcus Rashford. I conclude by suggesting future research directions to enhance the application of SAF theory as a tool for investigating food support organizing within and across countries. (shrink)

Male violence against women is at shocking levels in South Africa. According to Faul, ‘A woman is killed by an intimate partner every eight hours, a probable underestimate because no perpetrator is identified in 20 percent of killings’, whilst ‘More than 30 percent of girls have been raped by the time they are 18’. Reeva Steenkamp’s killing by her partner, Oscar Pistorius, came ‘the day before she planned to wear black in a “Black Friday” protest against the country’s excruciatingly high (...) number of rapes’. The purpose of this article is to reread a key biblical text regarding male violence against women in order to highlight how Jesus would want us to respond to such violence. The text is John 7:53–8:11. The NRSV: Catholic Edition entitles the story ‘The woman caught in adultery’. However, this title is problematic as it can lead to misleading readings of the text, as I will show, and so I have given it a different title, namely ‘The woman threatened with stoning’. (shrink)

Health inequalities are embedded in a complex array of social, political, and economic inequalities. Responding to health inequalities will require systematic action targeting all the underlying (“upstream”) social determinants that powerfully affect health and well‐being. Systemic inequalities are a major reason for the rise of modern populism that has deeply divided polities and infected politics, perhaps nowhere more so than in the United States. Concerted action to mitigate shocking levels of inequality could be a powerful antidote to nationalist populism. A (...) basic yet critical start to addressing health inequalities is to recognize them, which demands improving data collection and analysis. Certainly, global indicators show vast progress in reducing poverty and extending life. Yet aggregate health data mask a deeper reality: health gains have disproportionately benefited the well‐off, leaving the poor and middle‐class behind. (shrink)

This paper explores the phenomenon of moral shock in the context of the Palestinian conflict, with a view to understanding its implications for global ethical reactions. It suggests that moral shock may have moral significance and the potential for a positive impact at the global level. The paper is structured in three sections. The first explores the concept of moral shock. The second examines the armed conflict in Palestine through a moral shock perspective, highlighting specific (...) aspects and incidents within the conflict that could potentially lead to moral distress. The third section discusses the broader implications of moral shock in this context. It suggests that moral shock may lead to positive outcomes by highlighting global responses to the ongoing events and showing how people worldwide react to these events. (shrink)

Using U.S. Department of Justice data on state-level political corruption, we find that, consistent with the Harmful Corruption Environment Hypothesis (HCEH), firms situated in states with higher levels of corruption incur higher costs of equity (CoEs). These results are robust for additional controls, propensity score matching, use of instrumental variables, exogenous shocks, and alternate measures for main dependent and primary independent research variables. Our study extends the stream of literature that investigates the influence of local ethical or trust factors (...) on CoE and complements works by El Ghoul and colleagues and Gupta and colleagues. (shrink)

We examine whether the level of integrity in a society, i.e., social integrity, affects stock price crash risk. We explore two competing hypotheses. On the one hand, exposure to high levels of integrity may reduce managers’ incentives to obfuscate information, thereby leading to lower crash risk. On the other hand, social integrity may weaken outsiders’ monitoring of managerial behaviors, thus giving managers more opportunities to obfuscate information and, consequently, leading to higher crash risk. Using a sample of Chinese listed (...) firms, we find that firms located in regions with higher integrity have lower future stock price crash risk. This result is confirmed by a difference-in-difference analysis with an exogenous shock to social integrity. Further analysis suggests that increased information transparency is a potential channel through which social integrity affects stock price crash risk. Cross-sectional analyses suggest that the negative effect of social integrity on crash risk is more pronounced in firms with weaker internal control systems and firms with less negative media coverage. Overall, our study provides novel evidence that the ethical environment plays a significant role in shaping business ethics and influencing stock price crash risk. (shrink)

Many philosophy majors are shocked by the gap between the relative ease of lower-level philosophy courses and the difficulty of upper-division courses. This book serves as a necessary bridge to upper-level study in philosophy by offering rigorous but concise and accessible accounts of basic concepts and distinctions that are used throughout the discipline. It serves as a valuable advanced introduction to any undergraduate who is moving into upper-level courses in philosophy. While lower-level introductions to philosophy usually (...) deal with popular topics accessible to the general student in a piecemeal fashion, The Philosophy Major's Introduction to Philosophy offers coverage of important general philosophical concepts, tools, and devices that may be used for a long time to come in various philosophical areas. The volume is helpfully divided between a focus on the relation between language and the world in the first three chapters and coverage of mental content in the final two chapters, but builds a coherent narrative from start to finish. It also provides ample study questions and helpful sign-posts throughout, making it a must-have for any student attempting to engage fully with the problems and arguments in philosophy. Key Features Integrates topics from various areas of philosophy, such as philosophy of language, metaphysics, epistemology, ethics, and philosophical logic Provides descriptions of logico-mathematical tools necessary for philosophical studies, such as propositional logic, predicate logic, modal logic, set theory, mereology, and mathematical functions Makes connections with modern philosophy, including discussions of Descartes's skepticism and dualism, Locke's theory of personal identity, Hume's theory of causation, and Kant's synthetic a priori. Includes well-known entertaining puzzles and thought experiments such as the Ship of Theseus, the Statue and the Clay, a Brain in a Vat, and Twin Earth Lists helpful Exercise Questions and Discussion Questions at the end of each chapter and answers selected questions at the back of the book. (shrink)

This paper examines the role of mathematical idealization in describing and explaining various features of the world. It examines two cases: first, briefly, the modeling of shock formation using the idealization of the continuum. Second, and in more detail, the breaking of droplets from the points of view of both analytic fluid mechanics and molecular dynamical simulations at the nano-level. It argues that the continuum idealizations are explanatorily ineliminable and that a full understanding of certain physical phenomena cannot (...) be obtained through completely detailed, non-idealized representations. (shrink)

Does chemistry reduce to physics? If this means ‘Can we derive the laws of chemistry from the laws of physics?’, recent discussions suggest that the answer is ‘no’. But sup posing that kind of reduction—‘epistemological reduction’—to be impossible, the thesis of ontological reduction may still be true: that chemical properties are determined by more fundamental properties. However, even this thesis is threatened by some objections to the physicalist programme in the philosophy of mind, objections that generalize to the chemical case. (...) Two objections are discussed: that physicalism is vacuous, and that nothing grounds the asymmetry of dependence which reductionism requires. Although it might seem rather surprising that the philosophy of chemistry is affected by shock waves from debates in the philosophy of mind, these objections show that there is an argumentative gap between, on the one hand, the theoretical connection linking chemical properties with properties at the sub-atomic level, and, on the other, the philosophical thesis of ontological reduction. The aim of this paper is to identify the missing premises (among them a theory of physical possibility) that would bridge this gap. Introduction: missing elements and the mystery of discreteness The refutation of physicalism A combinatorial theory of physical possibilia Combinatorialism and the Bohr model Objections The missing premises and a disanalogy with mind. (shrink)

The scandals of the 1980s, extending into the 1990s, came as a profound shock to Australians and New Zealanders. Both countries have prided themselves – somewhat smugly and naively – on being open, fair and honest societies. So it was very disillusioning to see both corruption and gross dereliction of duty exposed in virtually every sphere of public life. Perhaps the most positive outcome, however, amidst an almost daily diet of amazing revelations, has been the ability of the system (...) – and especially the judiciary and the media – to expose and deal with corruption even at the highest level.Following an extensive survey and literature review, it is clear that there is now widespread awareness of the need for reform in many areas of public administration, corporate governance and professional behaviour. However, a continuing cause for concern is the lack of leadership in identifying and addressing complex ethical dilemmas, particularly in the areas of conflict of interest and disclosure. (shrink)

Agrifood scholars have long called for changes to the dominant food system, with the goal of making food systems more sustainable and just. This paper focuses on the ways in which recent and future food system shocks provide an opportunity for sustainable transitions in the food system. However, this requires strategic engagement on the part of alternative agrifood initiatives—agrifood niches—otherwise food systems are likely to return to business as usual. Drawing on the multi-level perspective (MLP) within the sustainability transitions (...) framework, core themes that emerge from social science studies of disasters in agrifood systems are identified. These are summarized as resources, polices, and practices that can assist niches in transforming agrifood regimes in response to disasters. The results highlight that while niches are generally independent of governments, niches would be better positioned to engage in post disaster agrifood change if they have some pre-existing connections with local or regional governments. (shrink)

While mainstream CSR research has generally explored and argued for positive ethical, social and environmental performance, critical CSR scholars argue that change has been superficial—at best, and not possible in any substantial way within the current capitalist system. Both views, however, only address the role of business within larger systems. Little attention has been paid to the everyday material CSR practice of individual managers. We go inside the firm to investigate how the micro-level acts of individual managers can aggregate (...) to drive transformation of the macro-level business logic. We draw on the strategy-as-practice approach to organize our research. The study reveals two orientations towards the integration of personal ethics into the workplace: abdication and activism. These orientations are supported by managerial practice such as reproductive and coping tactics and covert and overt tactics ; and, three enabling conditions of activist practice: empowerment and psychological safety, moral shock, and morality praxis. While our findings illustrate the tremendous challenges managers face when attempting to influence organizational practices towards their ethical and environmental aspirations, we also show that under specific conditions, individual managers can become fully engaged advocates and drivers of positive change from the inside. In so doing, our individual-level analysis of intrapreneurship provides a more complex picture of the possibilities for positive change than have been previously put forth by mainstream and critical CSR research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Self of Book 1 and the Selves of Book 2 Terence Penelhum One ofthe more familiar problems ofinterpretationin Hume's Treatise is that of reducing the sense of shock that arises from the apparent differences between what he says about the selfin book 1 and what he says about it in book 2. One way in which scholars have attempted to reduce it is to take him very (...) seriously when he distinguishes, in the book 1 discussion, "betwixt personal identity, as itregards our thought or imagination, and as it regards our passions or the concern we take in ourselves."1 If one does this, it becomes possible to see that what might seem to be inconsistent positions are compatible, and merely represent complementary aspects of an extended account of how human beings represent their natures and identities to themselves in thought and feeling and choice. This, at least, is now widely believed. The belief has led to very illuminating accounts of Hume's analysis of the emotional life and ita relationship to his more famous theories in epistemology.2 In spite of these, I think there is an egregious gap in Hume's psychology which we should not be tempted to suppose he has filled. Unless I have misread them, two recent authors have yielded to this very temptation. Since I have said Hume's psychology has an important gap in it, I should begin by making clear what the gap is, and emphasize that I do not think I have uncovered an inconsistency in Hume's theories of the self. He has, of course, been accused of such inconsistencies.3 His account in book 1 has itself been said to be inconsistent because he ascribes to the self there a tendency to confuse invariance and succession in telling us how we come to generate the fiction of continuing identity; such a story seems to ascribe a continuing reality to the mind in the very process ofshowing how the beliefin it can come toexistwhen there are onlysuccessive perceptions toconstitute it. This is a special application of a wider charge sometimes levelled against him, thatalthoughhisassociationism appearstoreduce allexplanation to relationships between perceptions, he is bound to depart from this restriction in ascribing tendencies and mistakes to the mind. Given the nature ofthe beliefhe is explainingwhen he discusses self-identity, the special application is troubling.4 He has also been accused of Volume XVIII Number 2 281 TERENCE PENELHUM inconsistencyin assumingat the outset ofhis discussion oftheindirect passions in book 2 that we have an idea, or even an impression, ofthe self, when in book 1 he has appeared to deny this. Many have argued (and I have been among them) that Hume can be acquitted of these charges. Mercer, for example, has made short workofthe last one.5 When Hume introduces the selfin book 2, he says clearly that he is referring to "self, or that succession of related ideas and impressions, of which we have an intimate memory and consciousness" (T 277), not to the idea of the pure ego constructed by rationalist philosophers. The charge of confusion in the argument of Treatise 1.4.6 has been rebutted by several writers, beginning with Nelson Pike.6 In the briefest summary: since the mind is nothing but a series of perceptions, Hume's question in book 1 is not a question about how it is that a mind he tacitly assumes to be more than this comes to think it is more than this, but a question about how the series that the mind actually is, comes to include within it from time to time perceptions ofthe series that represent it as having an identity that it (strictly) lacks. The actual relationship of the mind to its perceptions is one ofinclusion, and Hume's puzzle is how certain perceptionsofthe mind come to be in the mind. This reading ofHume may well leave him with some unattractive problems, but it does not convict him of contradicting himself. If something like this is accepted, we can see Hume in book 1 as combining scepticism about philosophical defences of a natural belief with the assumption of an obUgation to give an account of how... (shrink)

This theoretical development was carried out in response to the need of an interdisciplinary team of researchers of the complex concept of “social resilience of a person in a community”. An integration framework proposes to bring such efforts together. It includes aspects of the study of social resilience of a person in a community as a synergistic system, as one of the levels of a hierarchical system, as a problem-solving system.We consider synergistic social resilience as the subject’s ability to go (...) through shocks, which is enhanced by his capacity for self-learning and innovation. The authors analyzed the synergistic social resilience of a person in a community as a system of self-organization based on rhizome and network models. This also includes a person’s access to capital. At the same time, considering the system as synergistic reveals the probabilistic nature of its development. This does not rule out the possibility of developing the system’s stability by excluding its vulnerable members. The latter is an ethical dilemma.Hierarchy in social resilience is considered at the levels of interstate associations, states, individual branches of state functioning, territorial communities, individual social groups (professional groups, corporations or enterprises, public associations, religious communities, neighborhood communities, etc.), family, person. At the same time, we understand the completeness of the interdisciplinary study of the social stability of a person in the community through the management of the principle of “leaving no one behind” set by the Sustainable Development Goals.We also consider social resilience through a problem-solving orientation. This study proposes to focus on the fact that every person in his life can face a disaster to which he will not be able to adequately respond, based on the available internal resources, access to networks and capital. It can also apply to social groups, communities, and states. A possible solution in this case is an appeal from a more local to a more global level. Orientation to the solution of the problem opens the dialectic of hierarchical and synergistic aspects of social sustainability. It is as follows: an excess in the provision of solutions by the supersystem can become a detriment to the development of the local system, a lack of assistance can cause the death of the local system.Collectively, this forms an integrative framework for an interdisciplinary study of the social stability of a person in a community. Such a framework is designed to ensure the transformation of individual texts from various fields of scientific knowledge into a holistic multifaceted development that not only reveals concepts, but also opens up prospects for the development of social stability of a person in a community. (shrink)

Purpose of the study is to find out the interdependence of the event as a factor of transformations in the established areas of human life and everyday routine as a way of existence of social being, which cover various types of human activity. Theoretical basis of the research is based on understanding of everyday routine as a form of social reality, a complex and multidimensional object that is constantly evolving, includes new forms of reality, and is influenced by various social (...) changes. The main function of everyday routine is the survival of individual and society, therefore the stable foundations of human existence play a dominant role in every life. In turn the event serves as a way of being existence, has a singular character, an individual expression, identifies elements that do not fit into the usual framework of everyday life. Originality of the obtained results lies in understanding event as the opposition of the phenomena world to the out of experience world of being, unexpected innovation that leads to the emergence of behaviours and structures that are new and unusual for everyday life. Event is not identical to empirical facticity, does not correspond to the usual understanding of phenomena and processes, and leads to a break from the everyday life, as it causes significant changes in human life on the individual and social levels. Unexpected change in everyday life caused by event is a traumatic collision with another dimension of being for an individual, as a result of it new meanings may open. Conclusions. On the background of everyday life, which is able to be in different states, function in a variety of relationships, to be manifested in numerous structures, junctions and connections, the event assumes the prospect of a new reality, contrary to previous representations. From existential point of view, event is always an interruption of everyday life, as for example, love or religious conversion. A large-scale event causes shocks that affect most or all individuals and communities that use multiple ways to react to an event – interpretation, selection, glorification, silence, valuations adjustment, phenomena, facts, celebration of holidays, rituals that are periodically repeated. (shrink)

Crisis jargon has become endemic in modernity. Whether in radical or in affirmative versions, the idea that ‘crisis’ offers ‘opportunity’, in accordance with the meaning of crisis as ‘decision’, is widespread. This paper questions the relationship between modernity and crisis, first by highlighting the ways in which modernity itself has been cast as ‘crisis’: first as crisis of tradition, then as crisis of modernity itself. The main part of this paper then consists of a reading of modernity-as-crisis inspired by Walter (...) Benjamin, most notably by his Passagen-Werk. It consists of an attempt to consider ‘crisis’ as what Benjamin calls a ‘wish image’, an image that contains hidden utopian ideals. In invoking ‘crisis’, I argue, a conception of modernity as shock, raised to the level of the collective, becomes apparent. Crisis jargon thereby remains wedded to what Benjamin calls a mythical conception of history. The paper ends with a discussion of the political consequences that follow from this that are grounded in the relation between messianism and profane politics in Benjamin. (shrink)

Divergent evolution can explain how many proteins containing structurally similar domains, which perform a variety of related functions, have evolved from a relatively small number of modules or protein domains. However, it cannot explain how protein domains with similar, but distinguishable, functions and similar, but distinguishable, structures have evolved. Examples of this are the RNA‐binding proteins containing the RNA‐binding domain (RBD), and a newly established protein group, the cold‐shock domain (CSD) protein family. Both protein domains contain conserved RNP motifs (...) on similar single‐stranded nucleic acid‐binding surfaces. Apart from the RNP motifs, which have a similar function, the two families show little similarity in topology or amino acid sequence. This can be considered an interesting example of convergent evolution at the molecular level. Previously, a β‐sheet surface was found to interact with RNA in non‐homologous proteins from yeast, phage and man, revealing that this mode of RNA binding may be a widely recurring theme. (shrink)

The aetio-pathogenetic sequences and the physio-pathological patterns of diabetes, emphysema, cholera, circulatory shock and thrombosis have been analysed with respect to an evolutionary interpretation. The diseases, although reflecting alterations of processes that can always be described in physico-chemical language, occur only at the level of biological systems which reflects the decodification of genomic project: the teleonomic projects that have been developed during evolution. The concepts of evolutionary emergence and of downward causation have been used to discuss the relationship (...) between the molecular events responsible for the initiation of the disease, and the subsequent events responsible for the aetio-pathogenesis, for the systemic disarrangement and for the additional alterations of tissues and cells independent of the initial molecular events. In diabetes the systemic disarrangement, glycosuria and hyperglycemia, reflect the evolutionary emergence of the processes regulating carbohydrate metabolism, whereas the cardiovascular and neurological alterations are effects of the systemic disarrangement by a mechanism of downward causation. The complexity of the aetio-pathogenesis and of the physio-pathological patterns of diseases is due to the generation of information during the evolution of multi-hierarchical entities. The evolutionary epistemology approach is useful to explain the behaviour of complex systems. (shrink)

This book addresses nothingness as not only the untangible presence of an emotional, cultural, social, or even political void that is felt on an existential level, but has some solid foundations in reality. The death of a loved one, the social isolation of an individual, or the culture shock one may experience in another country are examples of situations in which an external sense of absence mirrors an internal psychological and philosophical sense of nothingness. Not much has been (...) explicitly written on nothingness in the history of psychology. On the other hand, nothingness seems to be implicitly embedded in many scholars' work. This duality of explicitly and implicitly expressed ideas about nothingness reveals how psychology finds inspiration in philosophy, and vice versa. The book aims to illustrate how the concept of the presence of absence--nothingness--fills a void in contemporary psychological theorizing. (shrink)

Abstract:Cities are increasingly faced with the impact of shocks or stresses, and the built environment is forced to respond to these changes in a resilient way. Especially urban waterfronts are faced with constant social, spatial and economic transformation. Centuries ago developed as industrial land, the waterfronts of New York City have since gone through extensive transformation processes and have resulted in complex, hybrid, and sequenced urban areas with a large mix of social, spatial and economic activities and conditions. However, twenty-first-century (...) waterfront redevelopment seems to replace these areas with more homogeneous and ‘clean’ masterplans that answer to the pressing residential and recreational market, but forgo the social and economic complexity and do not anticipate future changes in the existing environment. This paper looks at how urban waterfronts respond to the inevitable changes of the future, and compares how new urban waterfront redevelopments function in comparison to the initial post-industrial complex waterfronts. The paper investigates the resilience of homogeneous compared to heterogeneous waterfronts, and raises the question if there should be an alternative approach of tackling post-industrial waterfronts, answering to their urgent need of redevelopment while simultaneously considering its modularity and complexity on spatial, social, environmental and economic level. (shrink)

We introduce nudges in order to incite investors to choose Socially Responsible Investment funds instead of traditional funds. We have set up two online experiments with a total of 713 US retail investors, using three types of nudges to elicit their effects on investors’ SRI investments level: making SRI the default investment, introducing a SRI explanation message, and priming ethical values by displaying shocking images. Making SRI the default option is the most efficient nudge to influence investors towards SRI. (...) Its effect is twofold. First, around 50% of investors do not opt-out of the default allocation. Second, even investors who opt-out of the default allocation invest more in SRI than those in the control group, an effect that appears driven by anchoring. Although investors subjected to both priming and message content marginally increase their SRI investment, priming or message content in isolation appears to have a non-significant influence. For choice architects who want to steer retail investors towards SRI funds, making them the default option appears to be the most powerful nudge. (shrink)

Coronavirus disease 2019 escalated into a real pandemic within 3.5 months and had caused 183 000 deaths in 2020. The complexities of COVID-19 since the end of 2019 and throughout 2020 left a mouth full and the second wave has not least to be said. The purpose of this article is to challenge the response of the church in a time when her voice is mostly needed. During the lockdown Level 5, churches were amongst the many trends that had (...) to close their doors to the believers and the community. This was a great shock because churches throughout history have been known as safe havens and anchorages. Churches helped with answers to unanswered questions, and in some instances, confessional statements and creeds were born. In the case of COVID-19, a lot of conspiracy theories went viral about COVID-19 and the vaccines that were still in their research stage. Lots of speculations rose as to the cause of this pandemic. The implementation of 5G was viewed as the cause of the coronavirus at the beginning of 2020, and much had to be done to correct this fallacy. Another controversial fallacy was the link of the vaccination with the beast's mark, as was recently also insinuated in Chief Justice's prayer. Questions have already been asked, what is the voice of the church in this regard? Congregation deals with this in different ways. Hence the relevance to the question, how timely can exegesis be to contemporary ecclesiology? What would be relevant hermeneutics that could assist in embodying faith in a corona-defined world? CONTRIBUTION: This article strives to develop an interpretation of 666 that could be relevant to the questions asked and suggest a way forward in embodying faith in a corona-defined world and beyond. (shrink)

Bali island’s beautiful nature in Indonesia are the result of volcanic activity under the sea, more than 23 million years ago. The geology of Bali island lies in the Sunda mountains arc, part of the volcanic rings of Pacific ring of fire. This causes the condition of Bali island is often unstable in ancient times, due to the shocks of volcanic eruptions. One of the beautiful areas caused by ancient volcanic activity is the Caldera of Mount Batur. On the northwestern (...) side of the caldera of the ancient Mount Batur, the archaeological traces of statues in sacred venues have been found since the prehistoric Balinese civilization. The holy place built on the hill at the highest peak of this ancient Batur Mountain caldera, often called Pura Penulisan. This holy place is designed in accordance with local wisdom, the concept of punden berundak, a concept of the original architectural space of Indonesia since prehistoric times. The shape of the architectural space design follows the topography of the hills, in form of leveled terrace and equipped with plaza. Archaelogical of Pura Penulisan merges with the caldera of Mount Batur, which was formed due to eruption 5,500 years ago. Therefore, Pura Penulisan architecture and the ancient Batur Mountain caldera, are both a valuable heritage, containing knowledge, and can knit memories. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Whisper Before You GoJohn K PettyDavid came with a bang.1A momentary prelude from a dysphonic chorus of pagers announce “Level 1 Pediatric Trauma—MVC ejected” before the abrupt crescendo of the trauma bay doors opening. He is maybe two. Maybe three–years–old. It is hard to tell when a child is strapped in, strapped down, nonverbal, intubated, and alone.The flight team speaks for him, “Four–year–old boy improperly restrained in a (...) single–vehicle crash into a ditch. He was partially ejected. He was unresponsive and pulseless at the scene. He got CPR and code drugs, and they got a pulse back. Emergency medical service (EMS) took him to the nearest hospital where they needled his chest, called for air transport, and scanned him up. He has been shocky for us since we picked him up. Glasgow Coma Scale (GCS) has been three the whole time. They said his head scan showed subarachnoid hemorrhage.”With the words of the flight team as background narrative, we get about doing our thing—hopefully more method and less madness. Bang, bang, bang! Check the tube. Vital signs. IV fluids. Place a chest tube. Hang the blood. Quick X–ray. Neuro exam—nothing. Get him off the board. Warm him up. Place the orogastric (OG) tube. Bang, bang, bang!The neurosurgery resident opens the CT scans from the other hospital. The brain and cervical spine scans show a disaster: some swelling and bleeding in the higher brain, but the worst damage is in the lower brain, brainstem, and top of the spinal cord. I have heard a neurosurgeon describe this pattern before as “internal decapitation.” Such language never makes it into the patient’s chart. For David the last two words of the neurosurgery consult note will eventually read, “Prognosis grim.”He remains unstable in the trauma bay. Inaction is death. We ultrasound his heart, abdomen, and pelvis. He has fluid that shouldn’t be around his heart. He is dying of the neuro injury we cannot control, but the pericardial fluid might be giving him shock, and we can control that. We can’t ignore the fluid. Shouldn’t ignore it. At least, wouldn’t ignore it. So, we bang up to the operating room. Squeezing blood. Spiking fluid. Oxygen tank and crash cart. Up we go.In the operating room, we do much and we do well. We release the fluid around the heart and find it was CPR, not heart injury that put it there. In the pericardial flash we get a view of the cardiac athlete, pounding like the 26th mile of the marathon. We explore the abdomen and find it swollen but innocent of an injury that would take his life. We place our lines and tubes as the neurosurgeons place theirs. If nothing else, we will be able to measure what lies ahead.“Good work, team,” and we bump the door on the way to the pediatric intensive care unit (PICU).The care in the PICU is more Apache brave than Gaelic knight—more bottles, fewer scissors. The curtains and carpets mute the tones. Our efforts continue, but I get a word that David’s father has arrived. He is sitting in a small, private waiting room off of the main PICU waiting room. The PICU staff colloquially refer to this as “the bad news room.” I take a seat next to a solitary man who is having the worst day of his life. His worst day so far.“I am Dr. Petty, and I am one of the doctors who is taking care of your son. I am very sorry about what has happened. Maybe you can tell me a little bit about what you understand is going on, and I’ll tell you what I know.” [End Page 17]He tells me that his wife was driving David back from her sister’s house, just the two of them. He doesn’t know what happened, but he got a call from the other hospital about the crash. His wife was badly hurt. He heard that David had died, but they got him back. Both were transferred up to the... (shrink)

The idea that the technologies one uses and the work experiences one has influence cognition is old, but somewhat vague, focused on how technology induced generalisable habits of mind. Technology creates a familiar world, which changes in large and small shocks, rather than in rational steps. This kind of change, at the tacit level, has characteristics of liminality. Cognitive science provides a vocabulary for discussing this problem that connects with several different strands of social theory, and points to various (...) ways of conceptualising the effects of digitalisation. If we focus on the tacitisation of skilled performance, we can see how the familiar is created and recreated, and identify processes by which this occurs, specifically pattern recognition in a liminal or liminoid state. In the past, and in the classic anthropology of the liminal, the familiar consisted of a world of common or shared objects, and the liminal states involved sacred ones. In the digital world, the choice of experience is voluntary, and the worlds are diverse, but the effects of object-induced involuntary pattern recognition are the same: they organise and reorganise cognition at a tacit, non-discursive, level. (shrink)

This article on the evolution of economic and monetary policy in Belgium, which turned the "sick man of Europe" into one of the stronger European economies and allowed it to enter into EMU, stresses the role of the monetary authorities as a stabilising force in Belgium. It gives a detailed analysis of how these changes have allowed Belgium to regain the confidence of both monetary authorities and international investors after the devaluation of 1982. The policy responses to the oil (...) class='Hi'>shock at the beginning of the seventies broke with the policy mix which had until then been practised. Both the wage formation process andf iscal policy clearly spiralled out of control, the chiefresult of which was a drastic loss in international competitiveness. As a consequence, the current account showed a large deficit, the traditional level at which public deficit had stood rose dramatically, unemployment exploded and the financial structure of most corporations became fragile.A drastic realignment of economic policy started with the devaluation of the Belgian franc in 1982. This devaluation was accompanied by a series of measures aimed at preventing the inflationary pressures from triggering further devaluations, and hence at restoring credibility. These measures included restrictive fiscal policies and real wage cuts. By 1987 this recovery policy had successfully restored Belgian competitiveness, reduced the government deficit and restored the balance ofpayments equilibrium. Although public policies became less restrictive during the period 1988-1993, the central bank continued to gain international credibility. Significant stepsin this process were the abolition of the dual exchange rate system, the decision to peg the Belgian franc to the most stable currency in the ERM and the reform of the money markets in Belgium. The latter in particular helped to increase the central bank's independence, since this reform implied total control by the central bank over short term interest rates, it reduced significantly the automatic credit lines of the fiscal authorities with the central bank and it stipulated that revaluations of gold reserves should no langer be used to finance government budget deficits. By 1992 international credibility had been restored to such a degree that the Belgian franc became a strong currency during the 1992 crisis, obliging the central bank to come to the rescue of the weaker currencies under attack in September 1992 with a speculative inflow of capital of about 200 billion BEF. However this restored credibility continued to be fragile, as became evident during the 1993 exchange rate crisis when the Belgian franc was vigorously attacked by international speculation.The insufficient alignment of public and monetary policies proved to be at the heart of the financial problems of the 1993 crises. The Belgian government relaunched its policies of budgetary restriction and wage moderation, brought together in what was called the 'Global Plan'. This realignment of public policies to monetary policy swiftly restored the credibility of the Belgian franc, so that as early as January 1994 the Belgian franc converged to its central parity with an interest differential vis-à-vis the German mark of only about 2 %. This differential declined progressively. Indeed the global plan restored the confidence of the investors in Belgian economic policy. Financial markets now fully believed in the entry of Belgium into EMU and from then on no major difficulties were to arise. (shrink)

This review portraits FK506 binding protein (FKBP) 51 as “reactivity protein” and collates recent publications to develop the concept of FKBP51 as contributor to different levels of adaptation. Adaptation is a fundamental process that enables unicellular and multicellular organisms to adjust their molecular circuits and structural conditions in reaction to environmental changes threatening their homeostasis. FKBP51 is known as chaperone and co‐chaperone of heat shock protein (HSP) 90, thus involved in processes ensuring correct protein folding in response to proteotoxic (...) stress. In mammals, FKBP51 both shapes the stress response and is calibrated by the stress levels through an ultrashort molecular feedback loop. More recently, it has been linked to several intracellular pathways related to the reactivity to drug exposure and stress. Through its role in autophagy and DNA methylation in particular it influences adaptive pathways, possibly also in a transgenerational fashion.Also see the video abstract here. (shrink)

This paper argues that it is necessary to focus on gender rather than exclusively on women in discussions on global poverty eradication. It argues firstly, that the drivers of poverty are complex and multifaceted leading to a least two different forms of deprivation – transitory and structural poverty – each requiring different forms of analysis and treatment. Transitory poverty can arise as a consequence of an event or shock that would diminish an individual’s capacity to retain or secure employment (...) and where a State lacks an appropriate form of social protection. Structural poverty, on the other hand, arises where groups are excluded from the workforce on a more permanent basis due to a wide variety of factors of discrimination such as sex, race, ethnicity, and age. Focusing on the sex of an individual alone cannot explain why some are more likely to experience different forms of poverty than others. Policies that protect women against transitory poverty, such as care related allowances, are not sufficient to eradicate structural poverty. Secondly, structural poverty prompts an examination of gender roles and relations. Unlike the category of ‘women’, the concept of gender demands consideration of a wider range of intersecting factors that influence life chances. The structure of contemporary gender relations, where women continue to experience higher levels of violence, and carry the greatest burden of responsibility for non-market based production activities, create the social conditions where domination and dependence thrive, and where persistently high rates of poverty seem inevitable. Such circumstances are generated by human agency. Thus, thirdly, it argues that these circumstances can and should be changed through human action. Knowledge of these circumstances gives rise to moral obligations for both men and women to avoid upholding values and practices that lead to domination and dependence as a matter of basic justice. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Trauma, Recognition, and the Place of LanguageJuliet Mitchell (bio)Definitions of trauma abound within the psychoanalytic discipline. My own definition is going to be simple. A trauma, whether physical or psychical, must create a breach in a protective covering of such severity that it cannot be coped with by the usual mechanisms by which we deal with pain or loss. The severity of the breach is such that even if (...) the incident is expected, the experience cannot be foretold. We cannot thus make use of anxiety as a preparatory signal. The death of a sick relative, the amputation of a diseased limb may be consciously known about in advance, but if they are to be described as traumatic then the foreknowledge was useless. In trauma we are untimely ripped.Whether it is as childhood seduction, infantile abuse, shell shock, or war violence, or as a preoccupation with the place of neoteny and the trials of human birth, trauma is continually posited as the hypothetical “origin” of psychic states. However, although “trauma” is crucial to psychoanalytic theory, trauma in itself is not really the focus of its analysis. Freud proposed a “biological bedrock” on which psychic states were formed, but this bedrock was not the object of psychoanalytic inquiry. I suggest that what emerges as a motif in the many retheorizings of psychoanalysis time and again, as another “bedrock,” is trauma. One might call it an “experiential bedrock.” As with biology, it is crucial—but as the area of another mode of inquiry. Psychoanalysis is equipped to contribute to the understanding of the reaction to trauma, not to the trauma itself.In a colloquial context we tend to look from the perspective of the observer and label a range of difficult or tragic occurrences “traumatic.” Instead, I want to define trauma from the perspective of the person who experiences it. This means both that the same event will not always be traumatic for different people, and that the experience of different events, if they are experienced as trauma, will be the same whatever the event and whoever the sufferer. It was essentially for this reason that Freud eventually disagreed with the rich findings of Otto Rank, who proposed the trauma of birth as the origin of mankind’s neurosis. Trauma is the great equalizer. What differentiates us, since we were all born? Furthermore, what appears to be the trauma from the observer’s perspective may, from the viewpoint of the psychic response of the recipient, only be the catalyst that brings to the surface an experience which, were it not for this later event, might not in itself have been traumatic (or vice versa). Even so extreme an experience as the Holocaust may not breach the defenses of a particular individual. The catalytic event in the present triggers an earlier occurrence which becomes traumatic only by virtue of its retrospectively endowed meaning.Probably all animate matter can be traumatized; it would seem likely that the response to the breach in the human defensive system takes place at a generalizable psychosocial level. Recognition and language are interactional social processes; without another person neither a psyche nor language is possible. Object relations analysts, notably D. W. Winnicott, whom Max Hernandez addresses in his paper in this issue, have devoted their work to aspects of the psyche, Lacanians to language. To me the fields are interdependent and gain from being looked at together, both in their practice and in the theories that can [End Page 121] be applied to them. When we have a physical trauma it is common for an immediate aftereffect to be some uncertainty about words; even the ability to spell correctly can temporarily disappear. There are undoubtedly physiological explanations for this. But I shall argue that there are psychological parallels. Every patient whom I would regard as having had some relevant form of trauma had a specific relationship to language, and it is this that concerns me. In addition, Max Hernandez describes the breach in the defenses caused by the anal rape of a patient when he was a young boy. But neither the patient’s symptom nor his complaint on coming to a therapist for treatment pertains to... (shrink)

Aristotle, in making virtuous activity necessary but not sufficient for happiness, tries to do justice to the intuitive requirement that the content of happiness not be revised so as to shock our intuitions that happiness involves worldly success and enjoyment. But he also tries to do justice to the theoretical pull: happiness must involve virtuous activity over one's life as a whole. Aristotle runs into difficulties over the level of external goods required for the virtuous life to be (...) happy, as well as the results when the virtuous happy person loses external goods. (shrink)

The Asian Debt Crisis of 1997–2001 led to drastically higher levels of unemployment, resulting in enormous social anxiety and shock. For the first time in its history, South Korea's attention was forcibly drawn to homeless people. Both the new government of the first civilian president, Kim Dae Jung, and an emerging civil society began to pay unprecedented attention to homeless issues. In this new context, homelessness was constructed as a product of the economic crisis. However, although certain homeless men (...) who fit the category of employability and rehabilitation were considered ‘deserving’, long-term street living people and homeless women were disregarded and further marginalized through specific gendered processes. In particular, homeless women were rendered invisible and considered ‘undeserving’ because they fell outside of normative gender expectations, including the idea that a woman's place was in the home, regardless of their ability or desire to work. Building upon ‘needs-talk’ analysis created by Nancy Fraser, this paper exposes the important role of gender norms in the making of a neoliberal welfare citizenship in South Korea, by arguing that the narratives of homeless policy administrators and shelter managers designated homeless women as ‘undeserving’ welfare citizens. (shrink)

Through their transcript products genes regulate the rates at which an immense variety of transcripts and subsequent proteins occur. Understanding the mechanisms that determine which genes are expressed, and when they are expressed, is one of the keys to genetic manipulation for many purposes, including the development of new treatments for disease. Viewing each gene in a genome as a distinct variable that is either on or off, or more realistically as a continuous variable, the values of some of these (...) variables influence the values of others through the regulatory proteins they express, including, of course, the possibility that the rate of expression of a gene at one time may, in various circumstances, influence the rate of expression of that same gene at a later time. If we imagine an arrow drawn from each gene expression variable at a given time to a gene variable whose expression it influences a short while after, the result is a network, technically a directed acyclic graph. For example, the DAG in Figure 1 is a representation of a system in which the expression level of gene G1 at time 1 ) causes the expression level of G2, which in turn causes the expression level of G3. The arrows in Figure 1 which do not have a variable at their tails are “error terms” which represent all of the causes of a variable other than the ones explicitly represented in the DAG. The DAG describes more than associations—it describes causal connections among gene expression rates. A shock to a cell—by mutation, heating, chemical treatment, etc. may alter the DAG describing the relations among gene expressions, for example by activating a gene that was otherwise not expressed, producing a cascade of new expression effects. Although “knockout” experiments can reveal some of the underlying causal network of gene expression levels, unless guided by information from other sources, such experiments are limited in how much of the network structure they can reveal, due to the sheer number of possible combinations of experimental manipulations of genes necessary to reveal the complete causal network. Recent developments have made it possible to compare quantitatively the expression of tens of thousands of genes in cells from different sources in a single experiment, and to trace gene expression over time in thousands of genes simultaneously. cDNA microarrays are already producing extensive data, much of it available on the web. Thus there are calls for analytic software that can be applied to microarray and other data to help infer regulatory networks. In this paper we will review current techniques that are available for searching for the causal relations between variables, describe algorithmic and data gathering obstacles to applying these techniques to gene expression levels, and describe the prospects for overcoming these obstacles. (shrink)

An investigative reporter documents the destructive impact of the environmental movement in North America and beyond. When journalist Elizabeth Nickson sought to subdivide her twenty-eight acres on Salt Spring Island in the Pacific Northwest, she was confronted by the full force and power of the radical conservationists who had taken over the local zoning council. She soon discovered that she was not free to do what she wanted with her land, and that in the view of these arrogant stewards it (...) wasn’t really hers at all. Nickson’s long, frustrating, and eyeopening encounter with these zealots started her on a journey to investigate and expose the hugely destructive impact of the environmental movement on ordinary people and communities across North America—and the world. What she discovered is shocking. Forty million Americans have been driven from their land, and rural culture is being systematically crushed, even as wildlife, forests, and rangelands are dying. In Eco-Fascists, Nickson explores how environmental radicals have taken over government agencies at the local, state, and federal levels. The result? A wholesale sequestration of forest, range, and water—more than 40 percent of North America—impoverishing us all, especially the most vulnerable. This confiscation of America’s natural heritage is a major factor contributing to our current economic decline; until it is acknowledged and addressed, our economy will not recover. Nickson traces the tens of billions of dollars environmental nonprofits marshal every year to promote the notion that our essential natural systems are collapsing, and finds, in a brutal example of self-fulfilling prophesy, that their corrupted science is desertifying the heartland. She visits once-thriving communities that are turning to ghost towns because environmental legislation has forced mines, ranches, and mills to close and has forbidden critical forest, range, park, and wilderness maintenance. Eco-Fascists exposes the major fallacies of the environmental movement—from wildlife protection to zoning to forest-fire management—and introduces us to the individuals who are fighting back. Fast-paced, highly accessible, and sure to be controversial, this is a work that will change the national conversation about environmental protection and its impact. (shrink)

Over the past decade, there has been growing positive interest in nuclear technologies as a sustainable source of clean electricity for the West and as a factor of industrial and social growth in Southeast Asia. Both developed and developing countries face the need to meet growing energy consumption needs, which is especially difficult in the context of gas market shocks and large-scale green transition plans. The social dimension of this problem, especially in the reactor-building countries, often remains “behind the scenes”. (...) Russia is one of the oldest countries with a powerful nuclear plant system, but even here the public’s attitude to the “peaceful atom” is ambiguous. Socio-political radiophobia has accompanied the development of the nuclear industry since at least the Chernobyl accident, and sociological publications that would topicalize the mood of Russian citizens, their level of anxiety and trust in nuclear energy are still sparse. The article examines Russians’ perception of nuclear technology in general and specifically regarding the “Development of Engineering, Technologies and Scientific Research in the Use of Nuclear Energy in the Russian Federation” (DETSR) program and the Rosatom state corporation’s activities. Based on two waves of representative surveys conducted in April-May 2023-2024, we assess the factors that contribute to the formation of trust in the industry. Using factor regression analysis, structural equations, and nonparametric tests, we outline a demographic profile of a Russian “nuclear optimist” — such optimism being typical primarily for the well-off segments of the population. A key role in the interpretation is given to the awareness factor, the increase of which (in the long term) should smooth out the inequality in support for the industry. The issue of (dis)trust in the state and its impact on this support is also discussed. (shrink)

> Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change The 2022 report of the Intergovernmental Panel on Climate Change paints a dark picture of the future of life on earth, characterised by ecosystem collapse, species extinction and climate hazards such as heatwaves and floods.1 These are all linked to physical and mental health problems, with direct and indirect consequences of increased morbidity and mortality. To avoid these catastrophic (...) health effects across all regions of the globe, there is broad agreement—as 231 health journals argued together in 2021—that the rise in global temperature must be limited to <1.5°C compared with pre-industrial levels. While the Paris Agreement of 2015 outlines a global action framework that incorporates providing climate finance to low-income and middle-income countries, this support has yet to materialise.2 COP27 is the fifth Conference of the Parties (COP) to be organised in Africa since its inception in 1995. Ahead of this meeting, we—as health journal editors from across the continent—call for urgent action to ensure it is the COP that finally delivers climate justice for Africa and vulnerable countries. This is essential for the health of those countries, and for the health of the whole world. The climate crisis has had an impact on the environmental and social determinants of health across Africa, leading to devastating health effects.3 Impacts on health can result directly from environmental shocks and indirectly through socially mediated effects.4 Climate change-related risks in Africa include flooding, drought, heatwaves, reduced food production and reduced labour productivity.5 Droughts in sub-Saharan Africa …. (shrink)

The Issues at Issue: Heidegger declares metaphor to be a function of metaphysics. Ricoeur's tension theory of metaphor takes the understanding of metaphor beyond metaphysics. Ricoeur's theory of metaphor is a theory of metaphorical statement not of naming. The classical, lexical theory of metaphor focuses on a primary meaning of each metaphor. As such metaphor is merely ornamentation in language. What it names could more appropriately be accomplished in literal language. In contrast, metaphor is understood by Ricoeur to be a (...) semantic event made possible by three kinds of tensions. One may understand symbols to function with the same metaphorical tensions. In the case of symbols, however, these tensions function not at the level of the sentence but rather of the narrative. Metaphor and symbol both have an ‘ontological priority’ over other elements of discourse and experience. They ‘work’ because of the event character of both understanding and experience. Understanding and experience have event as their condition of possibility. Metaphor and symbol both have a ‘temporal priority’, as well, for they serve as the shock to think ‘more’. This can occur, however, because they are part of a circularity that is non-metaphysical, that is, the circularity of the event character of the Being-of beings. Hence, just as metaphors are always ‘larger’ than the sentence, so are symbols always ‘larger’ than the narrative. (shrink)