이 연구는 포스트휴먼 시대의 예술과 윤리를 고찰하되, 포스트휴먼 페미니즘 윤리의 맥락을 확장해간 포스트휴머니즘의 관점에서 포스트휴머니즘 기술성의 예술과 이타성을 윤리를 해명하고자 한다. 사이보그 담론을 비롯한 대부분의 포스트휴먼 담론들은 비인간적 요소를 통해 다시 인간을 사유하는 방식을 취하며, 인간 이외의 존재들과 공존하는 윤리적 지평에 대한 설명으로 작용한다. 이러한 윤리적 지평에서 비판적 포스트휴먼 페미니즘은 인간중심적 사고인 휴머니즘을 비판하며, 기존 서사인간의 서사를 해체하면서 기술성을 미학을 추구한다. 이런 비판적 포스트휴먼 페미니즘의 주창자들은 먼저 우리가 ‘포스트휴먼 시대’에 살고 있음을 인정하고, 휴머니즘의 지속적인 해체를 통해서 다중접속 이타성의 윤리를 구현한다. (...) 결국 이 연구는 이런 포스트휴먼 페미니즘과 이를 확대계승한 포스트휴머니즘이 어떻게 다중접속 ‘기술성’의 미학을 구현하면서도 인간이 아닌 다른 타자를 인정하며, 공존을 추구하는 다중접속 이타성의 윤리로 미래적 가치를 열어가는지, 그 한계는 무엇인지를 살펴보고자 한다. (shrink)

Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and signal‐modulating roles. Afadin is a complex modulator of cellular processes implicated in cancer progression, including signal transduction, migration, invasion, and apoptosis. In keeping with the complexities associated with the roles of adherens and tight junctions in cancer, afadin exhibits both tumor suppressive and pro‐metastatic functions. (...) In this review, we will explore the dichotomous roles that afadin plays during cancer progression. (shrink)

Actomyosin (actin‐myosin II complex)‐mediated contractile forces are central to the generation of multifaceted uni‐ and multi‐cellular material properties and dynamics such as cell division, migration, and tissue morphogenesis. In the present article, we summarize our recent researches addressing molecular mechanisms that ensure actomyosin‐mediated directional cell–cell junction remodeling, either shortening or extension, driving cell rearrangement for epithelial morphogenesis. Genetic perturbation clarified two points concerning cell–cell junction remodeling: an inhibitory mechanism against negative feedback in which actomyosin contractile forces, which (...) are well known to induce cell–cell junction shortening, can concomitantly alter actin dynamics, oppositely leading to perturbation of the shortening; and tricellular junctions as a point that organizes extension of new cell–cell junctions after shortening. These findings highlight the notion that cells develop underpinning mechanisms to transform the multi‐tasking property of actomyosin contractile forces into specific and proper cellular dynamics in space and time. (shrink)

Next‐generation sequencing (NGS) technologies have revolutionised the analysis of genomic structural variants (SVs), providing significant insights into SV de novo formation based on analyses of rearrangement breakpoint junctions. The short DNA reads generated by NGS, however, have also created novel obstacles by biasing the ascertainment of SVs, an aspect that we refer to as the ‘short‐read dilemma’. For example, recent studies have found that SVs are often complex, with SV formation generating large numbers of breakpoints in a single event ( (...) class='Hi'>multi‐breakpoint SVs) or structurally polymorphic loci having multiple allelic states (multi‐allelic SVs). This complexity may be obscured in short reads, unless the data is analysed and interpreted within its wider genomic context. We discuss how novel approaches will help to overcome the short‐read dilemma, and how integration of other sources of information, including the structure of chromatin, may help in the future to deepen the understanding of SV formation processes. (shrink)

Connexins were first identified in the 1970s as the molecular components of vertebrate gap junctions. Since then a large literature has accumulated on the cell and molecular biology of this multi‐gene family culminating recently in the findings that connexin mutations are implicated in a variety of human diseases. Over two decades, the terms “connexin” and “gap junction” had become almost synonymous. In the last few years a second family of gap‐junction genes, the innexins, has emerged. These have (...) been shown to form intercellular channels in genetically tractable invertebrate organisms such as Drosophila melanogaster and Caenorhabditis elegans. The completed genomic sequences for the fly and worm allow identification of the full complement of innexin genes in these two organisms and provide valuable resources for genetic analyses of gap junction function. BioEssays 23:388–396, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Hyperscanning studies using functional Near-Infrared Spectroscopy have been performed to understand the neural mechanisms underlying human-human interactions. In this study, we propose a novel methodological approach that is developed for fNIRS multi-brain analysis. Our method uses support vector regression to predict one brain activity time series using another as the predictor. We applied the proposed methodology to explore the teacher-student interaction, which plays a critical role in the formal learning process. In an illustrative application, we collected fNIRS data of (...) the teacher and preschoolers’ dyads performing an interaction task. The teacher explained to the child how to add two numbers in the context of a game. The Prefrontal cortex and temporal-parietal junction of both teacher and student were recorded. A multivariate regression model was built for each channel in each dyad, with the student’s signal as the response variable and the teacher’s ones as the predictors. We compared the predictions of SVR with the conventional ordinary least square predictor. The results predicted by the SVR model were statistically significantly correlated with the actual test data at least one channel-pair for all dyads. Overall, 29/90 channel-pairs across the five dyads presented significant signal predictions withthe SVR approach. The conventional OLS resulted in only 4 out of 90 valid predictions. These results demonstrated that the SVR could be used to perform channel-wise predictions across individuals, and the teachers’ cortical activity can be used to predict the student brain hemodynamic response. (shrink)

E. Machery, R. Mallon, S. Nichols and S. Stich, have argued that there is empirical evidence against Kripke’s claim that names are not descriptive. Their argument is based on an experiment that compares the intuitions about proper name use of a group of English speakers in Hong Kong with those of a group of non-Chinese American students. The results of the experiment suggest that in some cultures speakers use names descriptively. I argue that such a conclusion is incorrect, for the (...) experiment does not prove what it is purported to prove. (shrink)

Co-learning of multiple agents has been studied in co-learning settings, and how do they help, or many different disciplines under various guises. For hamper, learning and cooperation? example, the issue has been tackled by distributed • How do we characterize the process and the artificial intelligence, parallel and distributed com- dynamics of co-learning, conceptually, mathe- puting, cognitive psychology, social psychology, matically, or computationally? game theory (and other areas of mathematical econ- • how do social structures and relations interact omics), sociology, (...) anthropology, and many other with co-learning of multiple agents? related disciplines. (shrink)

Unlike the standard Quantum Computational Logic, where the carrier of information is conventionally assumed to be only the last qubit over a sequence of many qubits, here we propose an extended version of the QCL where the number and the position of the target qubits are arbitrary.

Gap junctions are ubiquitous plasma membrane specializations that allow cells to exchange small molecules and ions directly. The isolation, biochemical characterization and molecular cloning of the major protein of rat liver gap junctions lead to a clearer view of these membrane zones that allow cells to ‘talk’ to each other and co‐ordinate their activities in tissues and organs.

Replacements for the self-interest axiom may posit weak to strong theories of sociality. Strong sociality may be useful for positing social cognitive mechanisms and their evolution, but weak sociality may work better for identifying interesting group-level outcomes by focusing on deviations from self-interested psychological assumptions. Such theoretical differences are likely to be based on disciplinary expertise, and the challenge for Darwinian integration is to keep the conversation flowing.

ABSTRACT:Global multi-stakeholder initiatives are important instruments that have the potential to improve the social and environmental sustainability of global supply chains. However, they often fail to comprehensively address the needs and interests of various supply-chain participants. While voluntary in nature, MSIs have most often been implemented through coercive approaches, resulting in friction among their participants and in systemic problems with decoupling. Additionally, in those cases in which deliberation was constrained between and amongst participants, collaborative approaches have often failed to (...) materialize. Our framework focuses on two key aspects of these breakdowns: assumptions about the orientation of MSI participants, and the deliberation processes that participants use to engage with each other to create these initiatives and sustain them over time. Drawing from stakeholder and deliberation theories, we revisit the concept of MSIs and show how their deliberative capacity may be enhanced in order to encourage participants to collaborate voluntarily. (shrink)

A semantics is presented for belief revision in the face of common announcements to a group of agents that have beliefs about each other’s beliefs. The semantics is based on the idea that possible worlds can be viewed as having an internal-structure, representing the belief independent features of the world, and the respective belief states of the agents in a modular fashion. Modularity guarantees that changing one aspect of the world (a belief independent feature or a belief state) has no (...) effect on any other aspect of the world. This allows us to employ an AGM-style selection function to represent revision. The semantics is given a complete axiomatisation (identical to the axiomatisation found by Gerbrandy and Groeneveld for a semantics based on non-wellfounded set theory) for the special case of expansion. (shrink)

Adherens junctions play pivotal roles in cell and tissue organization and patterning by mediating cell adhesion and cell signaling. These junctions consist of large multiprotein complexes that join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The best-known adherens junction is the zonula adherens (ZA) that forms a belt surrounding the apical pole of epithelial cells. Recent studies in Drosophila have further illuminated the structure of adherens junctions. Scaffolding (...) proteins encoded by the stardust gene are novel components of the Crumbs complex, which plays a critical role in ZA assembly.1-3 The small GTPase Rap1 controls the symmetric re-assembly of the ZA after cell division.4 Finally, the asymmetric distribution of adherens junction material regulates spindle orientation during asymmetric cell division in the sensory organ lineage.5 BioEssays 24:690–695, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

These bibliographies, compiled in one volume, are a component of the computerized International Kierkegaard Bibliographic Database (IKBD) but stand alone because of their unique purpose. Part I consists of Bibliographic Remnants - items that have never been included in a published bibliography or supply additional information or substantive corrections to published bibliographies. Ninety-one of the 221 books, 143 of the 201 articles, and 139 of the 142 dissertations listed are unique to the IKBD. Part II consists of 115 items divided (...) into six media categories: audio tapes, films (including television and video), music, radio, slides, and theatre. These entries are sufficiently detailed in most cases to enable the researcher to trace the particular performance. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2015 Heft: 207 Seiten: 607-629.

The coupling of protein synthesis and folding is a crucial yet poorly understood aspect of cellular protein folding. Over the past few years, it has become possible to experimentally follow and define protein folding on the ribosome, revealing principles that shape co‐translational folding and distinguish it from refolding in solution. Here, we highlight some of these recent findings from biochemical and biophysical studies and their potential significance for cellular protein biogenesis. In particular, we focus on nascent chain interactions with the (...) ribosome, interactions within the nascent protein, modulation of translation elongation rates, and the role of mechanical force that accompanies nascent protein folding. The ability to obtain mechanistic insight in molecular detail has set the stage for exploring the intricate process of nascent protein folding. We believe that the aspects discussed here will be generally important for understanding how protein synthesis and folding are coupled and regulated. (shrink)