In submitting rats to tests such as running a maze, behaviorist researchers failed to take into account the interest and point of view of the rats. As a result, the research missed important questions and relations at hand. The critiques about experimenter effect and intuitive perception of researchers’ questions by research subjects can be more fully extended to animals as research subjects and interactants in research who perceive and interpret situations, set-ups, and questions. Taking meaning and biosemiotics (...) into account helps give a better model of animal subjectivity as exercised in the interpretation of situations and the pursuit of interest. (shrink)

In 2014, John O’Keefe was awarded the Nobel Prize in Physiology or Medicine for his work on the hippocampus and its role in encoding map-like representations. His contributions were significantly influenced by Morris water maze studies. O’Keefe himself acknowledged the pivotal role of the Morris water maze, stating that it remains the preeminent behavioral assay for assessing hippocampal function. Indeed, thousands of researchers have turned to the Morris water maze for evidence about navigation abilities and the effects (...) that stress, lesions, pharmaceutical interventions, and more can have on them. This body of studies constitutes an important scientific enterprise. -/- This dissertation is about some of the philosophical dimensions of Morris water maze studies. Chapter 1 is about the different types of information states (including representational states) found across hypotheses about Morris water maze performance. Chapter 2 is about systematic task failures reported in Morris water maze studies. I argue these impose a constraint on what can count as an explanation (a good hypothesis) of task success. While this has the air of a chopping block for scientific hypotheses, I see things a little differently. In Chapter 3, I argue that satisfying the constraint is a formidable challenge for any hypothesis. One that should make researchers second-guess the concepts and strategies employed to explain the roles information states play in the maze task. Chapter 4 focuses on two spatial concepts. I argue that researchers working definitions for the spatial concepts of distal (far) and proximal (near) in maze studies are problematic. They are not ecologically valid, and so claims about them do not generalize to real-life navigation behaviors like migration or scavenging behaviors. Following this, I present alternative definitions in terms of neural information about visual cues. The neural information relevant to this account is non-conceptual, and so it provides a sketch of the ways in which information states can fruitfully contribute to explanations of rat success and failure while maintaining ecological validity. -/- To sum, this dissertation navigates important philosophical dimensions of Morris water maze studies, illustrating the challenges and opportunities involved in using information states to explain and understand animal navigation. (shrink)

The role of individual factors in behavioral neuroscience is an important, but still neglected, area of research. For example, the Elevated Plus-Maze Test has been one of the most used paradigms to gauge unconditioned aversively motivated behavior in rodents. However, despite a great number of experiments with this test there have been only few efforts to assess systematic individual variations in the elevated plus-maze and related neurobiological functions. The present review aims to give, first, a general overview and (...) introduction about the test, and second, an animal model of anxiety based on natural variance of plus-maze behavior within a given unselected population of rats. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given as to where to go from here. (shrink)

Response to spatial and nonspatial change in wild and Wistar rats The purpose of the experiment was to investigate the effects of domestication on exploration in rats. The comparison was made between wild Warsaw-Wild-Captive-Pisula-Stryjek rats and Wistar laboratory rats. The study used a purpose-built maze divided into zones connected with a corridor. Objects were placed in two out of four zones. Their location and shape were subject to experimental manipulation. Transporter used to move rats (...) to the maze provided the opportunity for spontaneous exploration of the experimental arena. Rats were subjected to a series of 10 sessions, followed by a spatial or nonspatial change in the experimental arena, after which another 5 experimental sessions were conducted. The study revealed that wild rats had much higher exploration latency than their laboratory counterparts. At each analyzed stage, WWCPS rats spent much more time in the transporter than Wistar rats. Wistar rats spent much more time during the experiment on object interaction in the experimental arena. In post-manipulation sessions, however, it was wild rats that explored object zones relatively longer than laboratory rats. No differences in the animals' behavior depending on the type of change were observed. Results suggest that wild rats tend to explore much more cautiously than laboratory rats and are more sensitive to changes in their environment. The underlying cause of these differences is likely to be the higher level of stress in wild rats, resulting from threats in their natural habitat. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 7.1 (2002) 147-153 [Access article in PDF] Book Review Rattling the Cage: Toward Legal Rights for Animals Rattling the Cage: Toward Legal Rights for Animals Steven M. Wise. Foreward by Jane Goodall. Cambridge, Mass.: Perseus Books, 2000. pp. 384. US $17.50. ISBN 0-7382-0437-4 (Paperback) "Ancient philosophers claimed that all nonhuman animals had been designed and placed on this earth just for human beings. Ancient (...) jurists declared that law had been created just for human beings. Although philosophy and science have long since recanted, the law has not." Steven M. Wise, Rattling the Cage, p. 4. Readers of this journal are well-versed in the myriad ways in which nonhuman animals are harmfully exploited at the hands of human beings—from battery hens and veal calves to mass-produced pigs; from Pennsylvania pigeon shoots to canned hunts on Texas ranches; from rodeos to roadside zoos; from LD-50 toxicity tests on rats and Draize eye tests on rabbits to head trauma and infectious disease experimentation on primates. Despite other sticking points, it is by now uncontroversial among [End Page 147] nonanthropocentric theorists that, in utilitarian terms, the benefits to humans of the above practices fall far short of justifying the harms they cause to their nonhuman victims or, in deontological terms, that they violate the rights of creatures with inherent value. Indeed, these arguments are so well-rehearsed and so widely regarded as compelling that it no longer seems particularly bold to predict that if reason ever prevails over tradition and prejudice, the future will look back on this generation's treatment of our fellow creatures with the same kind of shame and condemnation with which European Americans regard our slaveholding past.More sobering but equally familiar is the observation that decisive arguments for the gross immorality of existing practices will bring about neither their elimination nor significant reform as long as the presumed legitimacy of human exploitation of nonhuman beings remains entrenched in both popular consciousness and economic, political, and legal institutions. In the interests of chipping away at popular apathy, academics should no doubt go on repeating the well-worn arguments against speciesism in classrooms, popular venues, and professional research. But in a world structured far more directly by the interests of a powerful few than by the values of the many, this consciousness-raising strategy properly plays at most a supporting role to the even more vital project of challenging and ultimately restructuring the institutions that sanction and carry out these injustices. In short, what nonhuman animals need from ethically sensitive intellectuals is not just rational argument, but effective legal and political action.One of the main institutional obstacles to progress in this area is undoubtedly the legal relegation of animals to property status—which is why Steve M. Wise's Rattling the Cage: Toward Legal Rights for Animals is such an important book. Wise teaches animal rights law at Harvard, Vermont, and John Marshall Law Schools and has spent more than twenty years fighting for animals in the legal system; his book displays the bittersweet fruit of that experience. The tenor throughout is a mixture of conviction in the justice of his cause—which cannot but sustain a vision of its eventual success—together with the frustration and determined patience borne from decades of butting up against an utterly implacable wall. An eloquent foreword by Jane Goodall, together with Wise's own harrowing first chapter, describe the nightmarish existences imposed on our nearest nonhuman relatives, the chimpanzees and bonobos, for the sake of science, entertainment, and profit—nightmares enabled by a legal system that [End Page 148] treats all nonhumans as mere things. An engaging storyteller with a synthetic conception of the history of ideas, Wise unearths the origins of this conception of animals in the Great Chain of Being, demonstrates its defeat by Darwinian science, and builds piece by piece a case—drawing heavily on research into animal consciousness—for extending legal rights at least to chimpanzees and bonobos.The substantive theses of this case are, first, that the denial of... (shrink)