The subjective experience of time is a fundamental constituent of human consciousness and can be disturbed under conditions of mental disorders such as schizophrenia or affective disorders. Besides the scientific domain of psychiatry, time consciousness is a topic that has been extensively studied both by theoretical philosophy and cognitive neuroscience. It can be shown that both approaches exemplified by the philosophical analysis of time consciousness and the neuroscientific theory of cross-temporal contingencies as the neurophysiological basis of human consciousness implemented in (...) the prefrontal cortex converge in 2 respects. Firstly, a tripartite conception of consciousness divides human cognition in 3 different temporal domains comprising retention, presentation, and protention and the past, the present, and the future corresponding to working memory, interference control, and preparatory set. Secondly, both concepts refer to the present as an extended duration that integrates information from the recent past and the future. We propose that the integration of phenomenological and neuroscientific approaches can stimulate the development of enriched pathophysiological concepts of mental disorders. This approach appears to be particularly fruitful with respect to schizophrenia that is interpreted as a structural disturbance of time consciousness. (shrink)

An emerging body of research comparing body image disturbance and eating problems among African American and white women suggests that there are major ethnic differences in these areas. African American women appear to be more satisfied with their weight and appearance than are white women, and they are less likely to engage in unhealthy weight control practices, yet they are more likely to have high rates of obesity. Drawing on both Black and white feminist literature on eating problems, this (...) article advances three arguments that may account for these differences: Black women may develop a strong positive self-valuation and an alternative beauty aesthetic to resist societal stigmatization, Black women may be less likely to acquire eating disorders due to differences in the cultural construction of femininity in Black communities, and positive body image among Black women may sometimes reflect a defensive need to deny health problems such as compulsive overeating and obesity. (shrink)

Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies. In the present study we investigate potential mechanisms of such disturbances of consciousness in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex differentiated DLB cases with and without DOC, being 62–66% higher in those with DOC. The were no differences between DLB patients with or without DOC (...) in 125I-labeled α-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly α4 and β2 subunits. (shrink)

ObjectiveDespite its prevalence, insomnia disorder remains poorly understood. In this study, we used machine learning to analyze the functional connectivity disturbances underlying ID, and identify potential predictors of treatment response through recurrent transcranial magnetic stimulation and pharmacotherapy.Materials and methods51 adult patients with chronic insomnia and 42 healthy age and education matched controls underwent baseline anatomical T1 magnetic resonance imaging, resting-stage functional MRI, and diffusion weighted imaging. Imaging was repeated for 24 ID patients following four weeks of treatment with pharmacotherapy, with (...) or without rTMS. A recently developed machine learning technique, Hollow Tree Super was used to classify subjects into ID and control groups based on their FC, and derive network and parcel-based FC features contributing to each model. The number of FC anomalies within each network was also compared between responders and non-responders using median absolute deviation at baseline and follow-up.ResultsSubjects were classified into ID and control with an area under the receiver operating characteristic curve of 0.828. Baseline FC anomaly counts were higher in responders than non-responders. Response as measured by the Insomnia Severity Index was associated with a decrease in anomaly counts across all networks, while all networks showed an increase in anomaly counts when response was measured using the Pittsburgh Sleep Quality Index. Overall, responders also showed greater change in all networks, with the Default Mode Network demonstrating the greatest change.ConclusionMachine learning analysis into the functional connectome in ID may provide useful insight into diagnostic and therapeutic targets. (shrink)

Synchronization of biological neurons is not only a hot topic, but also a difficult issue in the field of bioelectrical physiology. Numerous reported synchronization algorithms are designed on the basis of neural model, but they have deficiencies like relatively complex and poor robustness and are difficult to be realized. Morris-Lecar neuron is considered, and linear active disturbance rejection control is designed. Only one control input signal is utilized to synchronize membrane potentials of biological neurons. Meanwhile, in order to verify (...) the robustness of synchronization, sinusoidal signal and parameter perturbations are introduced in numerical simulations. LADRC can still achieve satisfactory synchronization. Both theoretical and numerical simulation results show that LADRC is capable of estimating and cancelling disturbances and uncertainties. Neither accurate neural models nor concrete disturbance signal models are indispensable. A more practical and effective thought is provided to address the synchronization between neurons. (shrink)

Present study compared disturbed eating attitudes among male and female university students. For which it as postulated that female university students would have more disturbed eating attitudes as compare to male students. For that reason 200 males and 200 female university students from various universities of Karachi were incorporated in the study. Their age ranged from 19 to 25. Participants after verbal and written covenantfrom the heads of their institution were asked to fill the respondents’ profile form to gather the (...) participant’s demographic information, followed by Eating Attitude Test which was used to know ones disturbed eating ways. For statistical evaluation t-test was applied, which specified that male university students experience more disturbed eating attitudes compare to female learners. This clears that distressed eating attempts are not limited to females, but is now affecting males as well. Thus to avert its budding prevalence, teaching institutions should supervise its amassed risks in their students and stimulate them to healthy lines of eating. (shrink)

It is a standard assumption in contemporary metaphysics that concrete objects come with a location in space and time. This applies not only to material objects and events, but also modes (such as the roundness of the apple, the softness of the pillow, Socrates' wisdom) and entities that have been called 'disturbances' (e.g. holes, folds, faults, and scratches). Taking the approach of descriptive metaphysics, I will show that modes and disturbances fail to have a bearer-independent spatial location. This allows for (...) a metaphysical explanation of the Chomskyan contrast between 'There is a fly believed to be in the bottle' and the unacceptable 'There is a flaw believed to be in the argument'. A subsidiary point this paper makes is that in their lack of a direct spatial location, modes need to be sharply distinguished from tropes as a category of foundationalist metaphysics that has been at the center of a pursuit of a one-category ontology since Williams (1953). (shrink)

A eukaryotic “baby machine” has been developed that produces synchronized cultures that display up to four synchronous cell cycles. 1 That such cells can be produced implies that methods unable to produce successive synchronized cell cycles may not actually synchronize cells. But most important, the baby machine method now opens the way for the study of the cell cycle of minimally disturbed, artifact‐free, well‐synchronized, mammalian cells. BioEssays 24:499–501, 2002. © 2002 Wiley Periodicals, Inc.

Philosophy lecturer and essayist Gary Jason tackles timely issues from education reform to the Arab Spring in his new anthology Disturbing Thoughts: Unorthodox Writings on Timely Issues. Disturbing Thoughts collects more than 160 political and social commentary essays published between 2010 and 2012. Among the many topics addressed are environmentalism, public employee pensions, education, and political reform. Today's headlines are filled with discussion on the growing dysfunction of unfunded pension benefits, the debate over immigration, and concerns about the shale industry. (...) Whatever the topic, Jason doesn't shy away from offering his opinion, asking, for instance, how could we allow in many more immigrants legally without causing financial strain. Disturbing Thoughts arrives as a follow-up to Jason's 2011 anthology, Dangerous Thoughts, which collected a similarly eclectic set of essays written between 1979 and 2010. His most recent articles include pieces published in Liberty, American Thinker, The Orange County Register, The Washington Times, and The American. Jason comes to issues from the classical liberal position-albeit with an unusual perspective that sets him apart from most other political commentators. Whether you agree or not, his views are sure to keep readers thinking. (shrink)

Robot manipulators have been extensively used in complex environments to complete diverse tasks. The teleoperation control based on human-like adaptivity in the robot manipulator is a growing and challenging field. This paper developed a disturbance-observer-based fuzzy control framework for a robot manipulator using an electromyography- driven neuromusculoskeletal model. The motion intention was estimated by the EMG-driven NMS model with EMG signals and joint angles from the user. The desired torque was transmitted into the desired velocity for the robot manipulator (...) system through an admittance filter. In the robot manipulator system, a fuzzy logic system, utilizing an integral Lyapunov function, was applied for robot manipulator systems subject to model uncertainties and external disturbances. To compensate for the external disturbances, fuzzy approximation errors, and nonlinear dynamics, a disturbance observer was integrated into the controller. The developed control algorithm was validated with a 2-DOFs robot manipulator in simulation. The results indicate the proposed control framework is effective and crucial for the applications in robot manipulator control. (shrink)

This article investigates an adaptive neural network control algorithm for marine surface vessels with time-varying output constraints and unknown external disturbances. The nonlinear state-dependent transformation is introduced to eliminate the feasibility conditions of virtual controller. Moreover, the barrier Lyapunov function is used to achieve time-varying output constraints. As an important approximation tool, the NN is employed to approximate uncertain and continuous functions. Subsequently, the disturbance observer is structured to observe time-varying constraints and unknown external disturbances. The novel strategy can (...) guarantee that all signals in the closed-loop system are semiglobally uniformly ultimately bounded. Finally, the simulation results verify the benefit of the proposed method. (shrink)

In Disturbed Consciousness, philosophers and other scholars examine various psychopathologies in light of specific philosophical theories of consciousness. The contributing authors—some of them discussing or defending their own theoretical work—consider not only how a theory of consciousness can account for a specific psychopathological condition but also how the characteristics of a psychopathology might challenge such a theory. Thus one essay defends the higher-order thought (HOT) theory of consciousness against the charge that it cannot account for somatoparaphrenia (a delusion in which (...) one denies ownership of a limb). Another essay argues that various attempts to explain away such anomalies within subjective theories of consciousness fail. Other essays consider such topics as the application of a model of unified consciousness to cases of brain bisection and dissociative identity disorder; prefrontal and parietal underconnectivity in autism and other psychopathologies; self-deception and the self-model theory of subjectivity; schizophrenia and the vehicle theory of consciousness; and a shift in emphasis away from an internal (or brainbound) approach to psychopathology to an interactive one. Each essay offers a distinctive perspective from the intersection of philosophy, consciousness research, and psychiatry. (shrink)

The field, as Steven Cooper describes it, is comprised of the inextricably related worlds of internalized object relations and interpersonal interaction. Furthermore, the analytic dyad is neither static nor smooth sailing. Eventually, the rigorous work of psychoanalysis will offer a fraught opportunity to work through the most disturbing elements of a patient's inner life as expressed and experienced by the analyst - indeed, a disturbance in the field. How best to proceed when such tricky yet altogether common therapeutic situations (...) arise, and what aspects of transference/countertransference should be explored in the service of continued, productive analysis? These are two of the questions that Steven Cooper explores in this far-ranging collection of essays on potentially thorny areas of the craft. His essays try to locate some of the most ineffable types of situations for the analyst to take up with patients, such as the underlying grandiosity of self-criticism; the problems of too much congruence between what patients fantasize about and analysts wish to provide; and the importance of analyzing hostile and aggressive aspects of erotic transference. He also tries to turn inside-out the complexity of hostile transference and countertransference phenomena to find out more about what our patients are looking for and repudiating. Finally, Cooper raises questions about some of our conventional definitions of what constitutes the psychoanalytic process. Provocatively, he takes up the analyst's countertransference to the psychoanalytic method itself, including his responsibility and sources of gratification in the work. It is at once a deeply clinical book and one that takes a post-tribal approach to psychoanalytic theory - relational, contemporary Kleinian, and contemporary Freudian analysts alike will find much to think about and debate here. (shrink)

The psychiatric diagnostic system, as exemplified by the DSM, is a pseudo-scientific framework for diagnosing sick Cartesian isolated minds. As such, it completely overlooks the exquisite context sensitivity and radical context dependence of human emotional life and of all forms of emotional disturbance. In Descartes’s vision, the mind is a “thinking thing,” ontologically decontextualized, fundamentally separated from its world. Heidegger’s existential phenomenology mended this Cartesian subject-object split, unveiling our Being as always already contextualized, a Being-in-the-world. Here I offer a (...) critique of studies in “phenomenological psychopathology” that presuppose the validity of the psychiatric diagnostic system and leave it unchallenged. In this vein, I contend that all emotional disturbances are constituted in an indissoluble context of human interrelatedness. Specifically, I claim that all emotional disturbances, including those objectified by the DSM, take form in relational contexts of severe emotional trauma. There are no psychiatric entities, only devastating contexts. Additionally, I show that Heidegger’s analyses of Angst, world-collapse, uncanniness, and thrownness into Being-toward-death provide extraordinary philosophical tools for grasping the existential significance of such contexts of emotional trauma. Applying Heidegger’s concept of authenticity, I suggest that emotional health entails an ease of passage—i.e., an absence of dissociation—between the world of trauma and the world of everydayness. (shrink)

Synchronization of biological neurons is not only a hot topic, but also a difficult issue in the field of bioelectrical physiology. Numerous reported synchronization algorithms are designed on the basis of neural model, but they have deficiencies like relatively complex and poor robustness and are difficult to be realized. Morris-Lecar neuron is considered, and linear active disturbance rejection control is designed. Only one control input signal is utilized to synchronize membrane potentials of biological neurons. Meanwhile, in order to verify (...) the robustness of synchronization, sinusoidal signal and parameter perturbations are introduced in numerical simulations. LADRC can still achieve satisfactory synchronization. Both theoretical and numerical simulation results show that LADRC is capable of estimating and cancelling disturbances and uncertainties. Neither accurate neural models nor concrete disturbance signal models are indispensable. A more practical and effective thought is provided to address the synchronization between neurons. (shrink)

Sextus seems to offer inconsistent accounts of the sceptics’ achievement of tranquillity, apparently saying both that the sceptics’ tranquillity is achieved by suspending judgement on all issues and that it is achieved by suspending judgement only on the issue of there being objective goods and evils. It is argued that Sextus does not make the latter claim. The reason for the sceptics’ achievement of tranquillity is to be found in the original perplexity that instigated scepticism and left them immune to (...) the value beliefs that disturb everyone else. After discussing this perplexity that gave rise to scepticism, the paper focuses on Sextus’ explanation of sceptical tranquillity and dogmatic disturbance. (shrink)

In his account of Pyrrhonism, Sextus Empiricus talks about the disturbance concerning matters of opinion that afflicts his dogmatic rivals and that he himself was afflicted by before his conversion to Pyrrhonism. The aim of the present paper is to identify the distinct sources of doxastic disturbance that can be found in that account, and to determine whether and, if so, how they are related. The thesis to be defended is that it is possible to discern three sources (...) of doxastic disturbance and that two of them are to be explained by reference to the third, which is the real cause of mental distress. The paper also considers whether the thesis in question entails that there is no reason for the Pyrrhonist to suspend judgment across the board, but only to suspend judgment about evaluative matters. (shrink)

This article deals with two aspects of psychoanalytic history. The first is the history of ideas, specifically the notions of a one- and two-person psychology that are in such wide use today. Second, the authors attend, much more critically, to a disturbance of memory (repeated distortion, omission, selective representation, and misrepresentation) that has accompanied scholarly discussion of these ideas for the past 50 years. Finally, the authors attempt to restore the original meaning of the person-psychology concept and illustrate its (...) relevance for contemporary psychoanalytic debate. (shrink)

In this work, a new intelligent control strategy based on neural networks is proposed to cope with some external disturbances that can affect quadrotor unmanned aerial vehicles dynamics. Specifically, the variation of the system mass during logistic tasks and the influence of the wind are considered. An adaptive neuromass estimator and an adaptive neural disturbance estimator complement the action of a set of PID controllers, stabilizing the UAV and improving the system performance. The control strategy has been extensively tested (...) with different trajectories: linear, helical, circular, and even a lemniscate one. During the experiments, the mass of the UAV is triplicated and winds of 6 and 9 in Beaufort’s scale are introduced. Simulation results show how the online learning of the estimator increases the robustness of the controller, reducing the effects of the changes in the mass and of the wind on the quadrotor. (shrink)

Hydraulic fracturing (‘fracking') has enabled the recovery of previously inaccessible resources and rendered new areas of the underground ‘productive’. While a number of studies in the US and UK have examined public attitudes toward fracking and its various impacts, how people conceptualise the deep underground itself has received less attention. We argue that views on resources, risk and the deep underground raise important questions about how people perceive the desirability and viability of subterranean interventions. We conducted day-long deliberation workshops (two (...) in each country), facilitating discussions among diverse groups of people on prospective shale extraction in the US and UK. Themes that emerged in these conversations include seeing the Earth as a foundation; natural limits (a greater burden than the subsurface can withstand versus simply overuse of natural resources); and ideas about the fragility, instability and opacity of the deep underground. We find that concerns in both countries were not limited to specific, localised impacts but also addressed ecosystem links between surface and subsurface environments and broader questions about the use, identification and value of natural resources. (shrink)

The launch of a revolutionary new scientific theory represents a rare occasion on which the apparently cumulative development of science might be influenced by particular events. Yet in the case of the Darwinian revolution it is often claimed that the theory of evolution by natural selection would have emerged more or less inevitably, given the scientific and cultural circumstances prevailing in mid-Victorian Britain. This essay challenges that claim by arguing that if Darwin had not been there to write his Origin (...) of Species the subsequent development of biology would have occurred along a line that steadily diverged from the sequence of events we actually experienced. There would certainly have been an evolutionary movement in the late nineteenth century, but there would have been no selection theory to disturb the progressionist assumptions of the time. A totally non-Darwinian evolutionism might not have generated the challenges that led to the emergence of modern genetics in the early twentieth century, resulting in a very different understanding of the relationship between development, heredity, and environment. (shrink)

The relation between noise and disturbance is investigated within the general framework of Galois connections. Within this framework, we introduce the notion of leak of information, mathematically defined as one of the two closure maps arising from the observable-channel compatibility relation. We provide a physical interpretation for it, and we give a comparison with the analogous closure maps associated with joint measurability and simulability for quantum observables.

Thomas Elsaesser claims the late Haneke as a director of ‘mind-game’ films, but his diagnosis of the appeal of such films fails to account for The White Ribbon . In this paper, I draw on the theory of radical interpretation developed by American philosopher Donald Davidson to uncover the film’s power. I argue that the focus on charity in Davidson’s account of the conditions under which an interpreter is able to find a foreign community intelligible illuminates the exquisite discomfort the (...) spectator experiences as she begins to understand the disturbed community that the film portrays. In addition, the film exposes that Davidson’s transcendental argument that language is a condition of mindedness ought to be extended along emotional and moral dimensions. We should not only hold that every rational mind is a language-user, but that every rational mind is an appropriate language-user, so as to account for minds that have true, justified beliefs but which are, nevertheless, disturbed. (shrink)

This paper investigates robust formation-containment control of discrete-time multiagent systems with exogenous disturbances. Based on the discrete-time disturbance observer method, both state feedback and output feedback control protocols are proposed. Formation-containment conditions are obtained and convergency analysis is given according to Lyapunov stability theory. And, the corresponding control gains are obtained by solving some discrete-time algebraic Riccati equations. Numerical simulations are presented to illustrate the theoretical findings.

This paper draws attention to an important methodological shortcoming in debates about what counts as a reason for belief. An extremely influential distinction in this literature is between reasons of the ‘right kind’ and the ‘wrong kind’. However, as I will demonstrate, arguments making use of this distinction often rely on a specific conception of epistemic rationality. Shifting focus to a reasonable alternative, namely a coherentist conception, can lead to surprising consequences—in particular, pragmatic reasons can, against orthodoxy, indeed be reasons (...) of the right kind for belief. (shrink)

Part of a special issue of Parallax on 'Field Philosophy and other experiments'. In a number of accounts, field philosophy has been described as providing freedom from disciplinary constraints. In this paper, however, I suggest the importance of paying closer attention to the strength of philosophy’s boundary policing and the consequences this might have for those interested in the approach. Discussing field philosophy in terms of disturbance, I highlight some of the difficulties and opportunities it produces. In particular I (...) focus on the labour involved in adopting new methods and working in new sites of enquiry. I suggest that reconstituting the ‘philosopher’ outside of their traditional habitats is no simple task. Still, I argue that field philosophers should lay claim to the boundary policing question ‘how is this philosophy?’ in order to proliferate accounts of what philosophy is and can be, with the hope that the discipline’s future might be turned more strongly towards supporting diversity rather than defending purity. Keywords: field philosophy; feminist philosophy; inclusion; methods; field research. (shrink)

Learning the psychological origins of our moral judgments can lead us to lose confidence in them. In this paper I explain why. I consider two explanations drawn from existing literature—regarding epistemic unreliability and automaticity—and argue that neither is fully adequate. I then propose a new explanation, according to which psychological research reveals the extent to which we are disturbingly disunified as moral agents.

Historically, academic journals have served a different purpose than the Academy itself. Journals have served as privileged sites for the articulation and concretization of specific modes of knowledge and control.

I construct a quantum-logical model of the type of situation that seems to be at the root of the problem of interpreting the projection postulate (Luders' rule) as a criterion of minimal disturbance. It is shown that the most natural way of characterizing minimal disturbance leads to contradictory conclusions concerning the final state.

Background: Cognitive impairment is one of the core symptoms of schizophrenia, which is considered to be significantly correlated to prognosis. In recent years, many studies have suggested that metabolic disorders could be related to a higher risk of cognitive defects in a general setting. However, there has been limited evidence on the association between metabolism and cognitive function in patients with early-stage schizophrenia.Methods: In this study, we recruited 172 patients with early-stage schizophrenia. Relevant metabolic parameters were examined and cognitive function (...) was evaluated by using the MATRICS Consensus Cognitive Battery (MCCB) to investigate the relationship between metabolic disorder and cognitive impairment.Results: Generally, the prevalence of cognitive impairment among patients in our study was 84.7% (144/170), which was much higher than that in the general population. Compared with the general Chinese setting, the study population presented a higher proportion of metabolic disturbance. Patients who had metabolic disturbance showed no significant differences on cognitive function compared with the other patients. Correlation analysis showed that metabolic status was significantly correlated with cognitive function as assessed by the cognitive domain scores (p < 0.05), while such association was not found in further multiple regression analysis.Conclusions: Therefore, there may be no association between metabolic disorder and cognitive impairment in patients with early-stage schizophrenia.Trial Registration: Clinicaltrials.gov, NCT02880462. Registered August 26, 2016. (shrink)

This Derridean reading of Freud asks the question of how we should read Freud with respect to sexual difference and what Derrida considers a radicalized concept of trace, a "scene of writing" of differance ---that is, how we should read Freud with respect to phallogocentrism. Throughout I consider the possible relationships between the "mainstyles" of various psychoanalyses, deconstructions, and feminisms. By analyzing what is most original for Freud---the cause of hysteria, the navel of the dream, the perceptual identity, the primal (...) phantasies, for example---I find that Freud consistently seeks a single origin, a "caput Nili," on which to base a grand narrative. At first this narrative is an etiology of hysteria, but it evolves into a masterplot of sexual development and later into one of humanity. The establishment of an oedipal origin and telos, and the masterplot based on them, moves psychoanalysis toward a totalizing theory, and therefore its openness to chance and something beyond what that theory can master is greatly reduced. ;I approach these topics in terms of a question of the ethics of psychoanalysis. This appropriative or reductive process of Freud's masterplotting is based on what Derrida calls "castration-truth" in his reading of Lacan, "Le facteur de la verite." In contrast to some theorists who appeal to the radical spirit of Freudian theory as a basis for their radicalization of psychoanalysis---specifically Barnaby B. Barratt's Psychoanalysis and the Postmodern Impulse---I argue that Lacan's phallogocentric "return to Freud" is actually a more faithful one since I find both "mainstyles" of these psychoanalyses based on a logic of lack or "castration-truth." I argue throughout that the radical spirit of Freud is at times overemphasized or exaggerated by Derridean theorists---and even Derrida himself, though rarely---and that the dominant specter of Freud is an "establishment" or appropriative one, rather than one which is radical or "other-wise." I connect this trend of Derridean thinkers claiming too much debt to psychoanalysis to these thinkers not taking seriously Freud's commitment and interest in an idealized phylogenetics: "phylo-'genetics.'" Since my establishment of this establishment specter of Freud as the "mainstyle" of Freudian theory itself risks reproducing exactly the kind of appropriative discourse I hope to problematize, I attempt to avoid such a reproduction by considering what remains of the radical spirit of Freudian theory in what might be called a deconstructive "technology of iterability;" a "cyborg-analysis;" or what I call "post-psychoanalysis.". (shrink)

The paper presents the phenomenological conception of bodily perception as a possible therapeutic model for treating melancholic depression. At the beginning, it discusses some key concepts of Freud’s psychoanalysis: instinct, memory, perception, narcissism and melancholia. Next, the Freudian theory of melancholia is compared with studies of phenomenological psychopathology. It is investigated how melancholia is based on the division of temporal relations. Finally, the main problem of the paper is investigated: can the structure of perception and its constitutive openness toward the (...) future represent a theoretical model for therapeutic practices designed to treat melancholic depression? (shrink)

Deep brain stimulation of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, (...) early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management. (shrink)