Human Brain Project: Ethics Management or Proceduralization of Reflexivity? Everywhere, the reflexivity and responsibility of research and innovation is called for – the neurosciences being no exception. Undesirable side effects of scientific‐technical developments should be recognized early on and opportunities for participation by non‐scientific actors should be made available. In addition to the well‐known reflective programs such as Technology Assessment, Public Understanding of Science, Ethical Legal and Social Implications (ELSI) of Science, Science Communication and Citizen Science, a (...) new program is emerging: Responsible Research and Innovation (RRI). With the dimensions of anticipation, reflexivity, inclusiveness and responsiveness advocated here, social accountability of research has just been expanded again: factually (applying to the scientific practice of all domains), temporally (becoming more and more permanent) and socially (involving more and more actors). The following study will first reconstruct the current prominence of RRI as the dynamics of a changing relationship between science and society, then explore into the claim and reality of RRI as documented in publicly available material. The observation: While RRI at the level of its program aims at legitimacy through democratization of knowledge production, the organization of RRI demonstrates highly orchestrated bureaucratic arrangements and procedures. In the case of the Human Brain Project, it thus becomes clear that and how RRI is being put to the service of supporting neuroinformatic big science through targeted reductions: it is mainly framed as ‘ethics management’ and hardly integrated into research practice or even public discourse. (shrink)

There has been a great deal of skepticism towards the value of the realism/anti-realism debate. More specifically, many have argued that plausible formulations of realism and anti-realism do not differ substantially in any way. In this paper, I argue against this trend by demonstrating how a hypothetical resolution of the debate, through deeper engagement with the historical record, has important implications for our criterion of theory pursuit and science policy. I do this by revisiting Arthur Fine’s ‘small handful’ argument for (...) realism and show how the debate centers on whether continuity should be an indicator for the future fruitfulness of a theory. I then demonstrate how these debates work in practice by considering the case of the Human Brain Project. I close by considering some potential practical considerations of formulating meta-inductions. By doing this, I contribute three insights to the current debate: 1) demonstrate how the realism/anti-realism debate is a substantive debate, 2) connect debates about realism/anti-realism to debates about theory choice and pursuit, and 3) show the practical significance of meta-inductions. (shrink)

The Human Brain Project (HBP) is a massive interdisciplinary project involving hundreds of researchers across more than eighty institutions that seeks to leverage cutting edge information and communication technologies to create a multi-level brain simulation platform (BSP). My worry is that some brain models running on the BSP will be persons. If this is right then not only will the in silico experiments the HBP envisions being carried on the BSP be unethical the mere (...) termination of certain brain models running on the BSP will be unethical. To assess the possible personhood of certain brain simulations I consider John Searle’s critique of strong AI. In arguing that Searle’s critique fails I conclude that the HBP must tread carefully and devise strict rules on how research using the BSP ought to proceed. (shrink)

The “Human Brain Project” (HBP) is a large-scale European neuroscience and information communication technology (ICT) project that has been a matter of heated controversy since its inception. With its aim to simulate the entire human brain with the help of supercomputing technologies, the HBP plans to fundamentally change neuroscientific research practice, medical diagnosis, and eventually the use of computers itself. Its controversial nature and its potential impacts render the HBP a subject of crucial importance (...) for critical studies of science and society. In this paper, we provide a critical exploratory analysis of the potential mid- to long-term impacts the HBP and its ICT infrastructure could be expected to have, provided its agenda will indeed be implemented and executed to a substantive degree. We analyse how the HBP aspires to change current neuroscientific practice, what impact its novel infrastructures could have on research culture, medical practice and the use of ICT, and how, given a certain degree of successful execution of the project’s aims, potential clinical and methodological applications could even transform society beyond scientific practice. Furthermore, we sketch the possibility that research such as that projected by the HBP may eventually transform our everyday world, even beyond the scope of the HBP’s explicit agenda, and beyond the isolated ‘application’ of some novel technological device. Finally, we point towards trajectories for further philosophical, historical and sociological research on the HBP that our exploratory analysis might help to inspire. Our analysis will yield important insights regardless of the actual success of the HBP. What we drive at, for the most part, is the broader dynamics of scientific and technological development of which the HBP agenda is merely one particularly striking exemplification. (shrink)

Purpose This paper aims to critically assess approaches to sex and gender in the Human Brain Project as a large information and communication technology project case study using intersectionality. Design/methodology/approach The strategy of the HBP is contextualised within the wider context of the representation of women in ICT, and critically reflected upon from an intersectional standpoint. Findings The policy underpinning the approach deployed by the HBP in response to these issues parallels Horizon 2020 wording and emphasises (...) economic outcomes, productivity and value, which aligns with other “equality” initiatives influenced by neoliberalised versions of feminism. Research limitations/implications Limitations include focussing on a single case study, the authors being funded as part of the Ethics and Society Subproject of the HBP, and the limited temporal period under consideration. Social implications The frameworks underpinning the HBP approach to sex and gender issues present risks with regard to the further entrenchment of present disparities in the ICT sector, may fail to acknowledge systemic inequalities and biases and ignore the importance of intersectionality. Shortcomings of the approach employed by the HBP up to March, 2018 included aspects of each of these risks, and replicated problematic understandings of sex, gender and diversity. Originality/value This paper is the first to use an intersectional approach to issues of sex and gender in the context of large-scale ICT research. Its value lies in raising awareness, opening a discursive space and presenting opportunities to consider and reflect upon potential, contextualised intersectional solutions to such issues. (shrink)

Responsible Research and Innovation (RRI) is an important ethical, legal, and political theme for the European Commission. Although variously defined, it is generally understood as an interactive process that engages social actors, researchers, and innovators who must be mutually responsive and work towards the ethical permissibility of the relevant research and its products. The framework of RRI calls for contextually addressing not just research and innovation impact but also the background research process, specially the societal visions underlying it and the (...) norms and priorities that shape scientific agendas. This requires the integration of anticipatory, inclusive, and responsive dimensions, and the nurturing of a certain type of reflexivity among a variety of stakeholders, from scientists to funders. In this paper, we do not address potential limitations but focus on the potential contribution of philosophical reflection to RRI in the context of the Ethics and Society subproject of the Human Brain Project (HBP). We show how the type of conceptual analysis provided by philosophically oriented approaches theoretically and ethically broadens research and innovation within the HBP. We further suggest that overt inclusion of philosophical reflection can promote the aims and objectives of RRI. (shrink)

In the future, the Human Genome Project could eventually open the way to perhaps the determination of the complete wiling diagram of the human brain. This kind of progress may move neuroscience forward into the next level of understanding of human neurophysiology, development and behavior. The next crucial step would be to know, exactly what are the function of this genes, and why its lack or alteration causes a certain disease. Although, genomic has in some (...) way contributed to almost every aspects of neurobiology, the results are both significant and troubling.One of the areas, where HGP will contribute to neuroscience is the mapping of qualitative or complex traits. Complex traits like appearence, intelligence and personality are likely to be affected by hundreds or thousands of different genes, rather than one or a few. On the other hand, the complex organisms are not just the simple result of the sum of their genes, nor do genes alone build the different part of organism or influence behaviour by themselves. In spite of the wide variety of misunderstanding, misinterpretation or possible misusing of these new genetic information, this sort of research may eventually lead to useful practical medical results for humans. This information can contribute to work out therapies to treat learning and memory disorders, neurological disorders like Alzheimer's disease, afflicting more and more people in an increasingly ageing population. Genetics believe, there are 3000 to 4000 hereditary diseases. Gene therapy could one day cure some of them, but only when all the details of their genetic basis are known. Biomedicine in the next century will probably have a completely new role in society based on the beginnings inherent in the HGP.There is a general agreement, that modern neuroscience raises important ethical concerns that not have been adequately addressed either by scientists themselves or by the bioethics community. Some scientists interpreted the rapid progress in neuroscience as additional conformation for a materialist account of human nature, resulting in an attack on traditional belief systems. There is a clear tension between the widely held believes and the intellectual views of many scientists. (shrink)

From the theoretical discussions, transdisciplinarity starts to have practical consequences in the development of programs that include consortia of universities, bringing together a large variety of professionnals who set ambitious goals, such as the Human Genome Project in the past decade, and also the Human Brain Project for this decade. We intend to present an approach in the spirit of the new paradigms of knowledge in the Human Brain Project generous program started (...) earlier this year in Europe. A possible transdisciplinary approach on brain functions and structure is to bring a valuable, significant and innovative, unconventional contribution to the theory of multi-scale topics of the HBP project. More precisely, we intend to develop the subproject Mathematical and Theoretical Foundations of Brain Research within the HBP project. Our approach aims at exploring brain function from the perspective of the theories which influenced the last decade researches in Physics and Mathematics, such as the fractal theory, chaos and the dynamics of the nonlinear systems, in order to formulate new theories regarding brain mechanisms. We bring together models and new theories based on a principled approach to nonlinear reality. We wish to develop a new paradigm for assessing brain function, the theory of complex systems, which requires a revolutionary attitude, by rethinking how brain works and it is biologically structured. By this approach, we intend to study not only the corpuscular, but also the wave part of the matter. (shrink)

Any account of “what is special about the human brain” (Passingham 2008) must specify the neural basis of our unique ability to produce speech and delineate how these remarkable motor capabilities could have emerged in our hominin ancestors. Clinical data suggest that the basal ganglia provide a platform for the integration of primate-general mechanisms of acoustic communication with the faculty of articulate speech in humans. Furthermore, neurobiological and paleoanthropological data point at a two-stage model of the phylogenetic evolution (...) of this crucial prerequisite of spoken language: (i) monosynaptic refinement of the projections of motor cortex to the brainstem nuclei that steer laryngeal muscles, presumably, as part of a “phylogenetic trend” associated with increasing brain size during hominin evolution; (ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven by human-specificFOXP2mutations.;>This concept implies vocal continuity of spoken language evolution at the motor level, elucidating the deep entrenchment of articulate speech into a “nonverbal matrix” (Ingold 1994), which is not accounted for by gestural-origin theories. Moreover, it provides a solution to the question for the adaptive value of the “first word” (Bickerton 2009) since even the earliest and most simple verbal utterances must have increased the versatility of vocal displays afforded by the preceding elaboration of monosynaptic corticobulbar tracts, giving rise to enhanced social cooperation and prestige. At the ontogenetic level, the proposed model assumes age-dependent interactions between the basal ganglia and their cortical targets, similar to vocal learning in some songbirds. In this view, the emergence of articulate speech builds on the “renaissance” of an ancient organizational principle and, hence, may represent an example of “evolutionary tinkering” (Jacob 1977). (shrink)

Our understanding of the cognitive functions of the human brain has tremendously benefited from the population functional Magnetic Resonance Imaging (fMRI) studies in the last three decades. The reliability and replicability of the fMRI results, however, have been recently questioned, which has been named the replication crisis. Sufficient statistical power is fundamental to alleviate the crisis, by either “going big,” leveraging big datasets, or by “going small,” densely scanning several participants. Here we reported a “going small” project (...) implemented in our department, the Bergen breakfast scanning club (BBSC) project, in which three participants were intensively scanned across a year. It is expected this kind of new data collection method can provide novel insights into the variability of brain networks, facilitate research designs and inference, and ultimately lead to the improvement of the reliability of the fMRI results. (shrink)

This article illustrates the practical usefulness of transdisciplinary work for practical theology by showing how input from an occupational therapist informed my understanding and interpretation of the story of Hannetjie, who had been sexually abused as a child. This forms part of a narrative practical theological research project into the spirituality of female adult survivors of childhood sexual abuse. Transdisciplinary work is useful to practical theologians, as it opens possibilities for learning about matters pastors have to face, but may (...) not have knowledge about. A short retelling of Hannetjie’s story is given to provide information about the context of the research. Next, the transdisciplinary process that was followed is mentioned, and the questions that the transdisciplinary team had to respond to are discussed. Following that, I focus more specifically on the occupational therapist’s answers, and the knowledge gained from her contribution, as an example of how a co-researcher from a divergent discipline can inform a theological study. In this case, knowledge was shared about sensory integration and how the brain processes traumatic stimuli, such as sexual abuse. Lastly, the interrelationship between Hannetjie’s body stories, mind stories and spirit stories is discussed to show how the learning received from occupational therapy affected my thinking about Hannetjie’s stories and the relationships between them. Thus, it is concluded that transdisciplinary work has great value for practical theology, especially in the pastor’s daily work with people who are struggling with difficult stories, because we cannot listen to people’s spirit stories in isolation. They are inextricably intertwined with all our stories about ourselves. (shrink)

Human brain organoids are three-dimensional masses of tissues derived from human stem cells that partially recapitulate the characteristics of the human brain. They have promising applications in many fields, from basic research to applied medicine. However, ethical concerns have been raised regarding the use of human brain organoids. These concerns primarily relate to the possibility that brain organoids may become conscious in the future. This possibility is associated with uncertainties about whether and (...) in what sense brain organoids could have consciousness and what the moral significance of that would be. These uncertainties raise further concerns regarding consent from stem cell donors who may not be sufficiently informed to provide valid consent to the use of their donated cells in human brain organoid research. Furthermore, the possibility of harm to the brain organoids raises question about the scope of the donor’s autonomy in consenting to research involving these entities. Donor consent does not establish the reasonableness of the risk and harms to the organoids, which ethical oversight must ensure by establishing some measures to mitigate them. To address these concerns, we provide three proposals for the consent procedure for human brain organoid research. First, it is vital to obtain project-specific consent rather than broad consent. Second, donors should be assured that appropriate measures will be taken to protect human brain organoids during research. Lastly, these assurances should be fulfilled through the implementation of precautionary measures. These proposals aim to enhance the ethical framework surrounding human brain organoid research. (shrink)

We comment on the proposition “that lower temperatures and especially greater seasonal variation in temperature call for individuals and societies to adopt … a greater degree of self-control” (Van Lange et al., sect. 3, para. 4) for which we cannot find empirical support in a large data set with data-driven analyses. After providing greater nuance in our theoretical review, we suggest that Van Lange et al. revisit their model with an eye toward the social determinants of self-control.

The author of The Reality of Time and the Existence of God turns his critical conceptual acumen to finding an intellectually viable path between the current polarities of dualism and materialism. By considering human beings as language-using animals he can critically appraise “representational” views of concept formation, as well as show how current “research programs” which presuppose a “materialist” basis stem from an unwitting adoption of a dualist picture of mind and body. His alternative is rooted in classical thinkerslike (...) Aquinas and responsive to the critiques of Wittgenstein, yet constructive in ways in which those critiques failed to be. This essay aims to help readers undertake a taxing inquiry by guiding them through its main theses. (shrink)

The aim of this paper is to clarify specific aspects of the impact of the brain-machine interface on our understanding of subjectivity. The brain-machine interface is presented as a phase of cyborgization of humans. Some projects in the field of brain-machine interface are aimed at enabling consensual telepathy - communication without symbolic mediation. Consensual telepathy refers to one of potential ways of transmission of information within singularity. Therefore, consensual telepathy is an important aspect of singularity. Singularity or (...) human-machine symbiosis shows some similarities with child-mother unity. Therefore, the psychodynamic perspective might be considered useful in thinking about human-machine symbiosis. Knowledge from developmental psychodynamic psychology combined with insights by Slavoj Zizek and Jean Baudrillard provides an additional perspective looking at human-machine symbiosis. The paper claims that if consensual telepathy becomes another way of communication, it will have the potential to annihilate subjectivity making it schizophrenic. At the same time, we look at the possibility of an escape from our inner world through the prism of addictions. (shrink)

Dualist and Reductionist theories of mind disagree about whether or not consciousness can be reduced to a state of or function of the brain. They assume, however, that the contents of consciousness are separate from the external physical world as-perceived. According to the present paper this assumption has no foundation either in everyday experience or in science. Drawing on evidence for perceptual projection in both interoceptive and exteroceptive sense modalities, the case is made that the physical world as-perceived is (...) a construct of perceptual processing and, therefore, part of the contents of consciousness. A finding which requires a Reflexive rather than a Dualist or Reductionist model of how consciousness relates to the brain and the physical world. The physical world as-perceived may, in turn be thought of as a biologically useful model of the world as described by physics. Redrawing the boundaries of consciousness to include the physical world as-perceived undermines the conventional separation of the 'mental' from the physical', and with it the very foundation of the Dualist-Reductionist debate. The alternative Reflexive model departs radically from current conventions, with consequences for many aspects of consciousness theory and research. Some of the consequences which bear on the internal consistency and intuitive plausibility of the model are explored, e.g. the causal sequence in perception, representationalism, a suggested resolution of the Realism versus Idealism debate, and the way manifest differences between physical events as-perceived and other conscious events are to be construed. In the present paper I wish to challenge some of our most deeply-rooted assumptions about what consciousness is, by re-examining how consciousness, the human brain, and the surrounding physical world relate to each other. (shrink)

The claim defended in the paper is that the mechanistic account of explanation can easily embrace idealization in big-scale brain simulations, and that only causally relevant detail should be present in explanatory models. The claim is illustrated with two methodologically different models: Blue Brain, used for particular simulations of the cortical column in hybrid models, and Eliasmith’s SPAUN model that is both biologically realistic and able to explain eight different tasks. By drawing on the mechanistic theory of computational (...) explanation, I argue that large-scale simulations require that the explanandum phenomenon is identified; otherwise, the explanatory value of such explanations is difficult to establish, and testing the model empirically by comparing its behavior with the explanandum remains practically impossible. The completeness of the explanation, and hence of the explanatory value of the explanatory model, is to be assessed vis-à-vis the explanandum phenomenon, which is not to be conflated with raw observational data and may be idealized. I argue that idealizations, which include building models of a single phenomenon displayed by multi-functional mechanisms, lumping together multiple factors in a single causal variable, simplifying the causal structure of the mechanisms, and multi-model integration, are indispensable for complex systems such as brains; otherwise, the model may be as complex as the explanandum phenomenon, which would make it prone to so-called Bonini paradox. I conclude by enumerating dimensions of empirical validation of explanatory models according to new mechanism, which are given in a form of a “checklist” for a modeler. (shrink)

The increasing use of information and communication technologies (ICT) to help facilitate neuroscience adds a new level of complexity to the question of how ethical issues of such research can be identified and addressed. Current research ethics practice, based on ethics reviews by institutional review boards (IRB) and underpinned by ethical principalism, has been widely criticised and even called ‘imperialist’. In this paper, we develop an alternative way of approaching ethics in neuro-ICT research, based on discourse ethics, which implements responsible (...) research and innovation through dialogues. We draw on our work in Ethics Support, using the Human Brain Project as empirical evidence of the viability of this approach. (shrink)

The recently published BRAIN 2.0 Neuroethics Report offers a very helpful overview of the possible ethical, social, philosophical, and legal issues raised by neuroscience in the context of BRAIN’s research priorities thus contributing to the attempt to develop ethically sound neuroscience. In this article, we turn to a running theme of the document: the need for an ethical framework for the BRAIN Initiative and for further integration of neuroethics and neuroscience. We assess some of the issues raised (...) and provide an explanation of how we have addressed them in the Human Brain Project. We offer our experience in the HBP as a potential contribution to the international debate about neuroethics in the big brain initiatives. Our hope is that among other things, the type of exchange proposed by this AJOB special issue will prove productive in further identifying and discussing the issues and in inspiring appropriate solutions. (shrink)

Research on human-animal chimeras have elicited alarms and prompted debates. Those involving the generation of chimeric brains, in which human brain cells become anatomically and functionally intertwined with their animal counterparts in varying ratios, either via xenografts or embryonic co-development, have been considered the most problematic. The moral issues stem from a potential for “humanization” of the animal brain, as well as speculative changes to the host animals’ consciousness or sentience, with consequential alteration in the animal (...) hosts’ moral status. However, critical background knowledge appears to be missing to resolve these debates. Firstly, there is no consensus on animal sentience vis-à-vis that of humans, and no established methodology that would allow a wholesome and objective assessment of changes in animal sentience resulting from the introduction of human brain cells. Knowledge in interspecies comparative neuropsychology that could allow effective demarcation of a state of “humanization” is also lacking. Secondly, moral status as a philosophical construct has no scientific and objective points of reference. Either changes in sentience or humanization effects would remain unclear unless there are some neuroscientific research grounding. For a bioethical stance based on moral status of human-animal brain chimera to make meaningful contributions to regulatory policies, it might first need to be adequately informed by, and with its arguments constructed, in a manner that are factually in line with the science. In may be prudent for approved research projects involving the generation of human-animal brain chimera to have a mandatory component of assessing plausible changes in sentience. (shrink)

Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise, computerized cognitive training and a combined groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited. In this study we report intervention-related changes in plasma biomarkers and structural-MRI and how (...) they related to changes in physical activity and individual variables and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-α were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 341 if you started asking them questions about possible worlds. But Bradley's contribution is to have given us a painstaking and thorough reading of some extremely tightly wound and important aspects of the Tractatus, to have brought that text into direct contaot with con· temporary issues, and to have made progress toward showing that how· ever remarkable we thought the Tractatus was, it is still more remarkable (...) than that. JOHN CHURCHILL Hendrix College Conway, Arkansas The Human Person: Animal and Spirit. By DAVID BRAINE. Notre Dame, Indiana: University of Notre Dame Press, 1992. Pp. xxv + 555. $32.95 (cloth). Any study in philosophical anthropology that rejects both mate· rialism and dualism, and seeks to set forth a " holistic " alternative, may be met in many quarters with some skepticism today-especially if that alternative seeks to accommodate itself to religious teaching regarding the soul's continued existence after death. For, it will be asked, on the one hand, how can it deny that the esse of the human being ceases at death (538) without affirming some sort of dualism? On the other hand, unless it is some sort of soft-headed New Age philosophy (which this most certainly is not), how can it sustain its claim to "holism" while rejecting the monolithic materialism of those whom Walker Percy once described as our "brain engineers, neuropharmacologists, and chemists of the synapses "? The challenge is " how to produce an account which allows the human person to continue exist· ing after death, and even to have body restored to it, while remaining completely faithful to the insight that it belongs to human nature to be bodily," and, at the same time, to " avoid reerecting the soul into a complete substance" (xix). The peculiar obstacle faced by such a project is the pervasive proclivity towards reductionism in modern accounts of human nature stemming from the impress of both materialism and dualism. Both analyze the human person into an aggregate of parts in certain relations, the behavior of the whole being ·the result of the interactions of these parts. " In all this the materialist has exactly the same picture as the dualist. Indeed, unless the mental can first be represented as inner, logically independent of anything in the ' outer man ' and the ' world,' there is no way in which it can be identified with a brain-process or 342 BOOK REVIEWS state" (3). So whether one thinks of the mind as an independent en· tity (as in dualism), or not (as in materialism), the body is left to be accounted for by the brain engineers and their aggregates of physi· ological, anatomical, neurological, and chemical causes. And since materialism involves no complicating questions about causal interaction between the physical and the mental (as in dualism), it is usually preferred on grounds of its simplicity-all causation being subsumed under the physical. In this ambitious tome, David Braine, a philosopher at the University of Aberdeen, offers a thoroughgoing analysis and critique of such views, whereby he undertakes to overturn these ways of viewing human nature and to offer a holistic alternative. He sets forth a framework for understanding things like perceiving, doing, and speaking as irreducibly the acts of the psychosomatically integrated beings to which we normally attribute them-an understanding that conforms to the ordinary experience of such acts in ourselves and in others. He seeks to expose how materialist arguments repeat the mistakes of the dualists by reducing human beings (and other animals) to their aggregate parts, segmented sequences, and their interrelations. He takes issue with the arguments of recent analytical philosophers (such as Davidson and Dummett) in detail, and sets forth a holistic alternative-both with re· spect to the human person as " animal" and as " spirit." As to the human as "animal," Braine notes, accordingly, that "it is the bodily animal being as such, not just its mind, which is an ' I ', a ' he or she ', a focalized subject in relation to the world. The primary reason why human behaviour cannot be simulated by a computer does not lie in things special to human beings, but in the fact that this fo. calized psychophysical structure which they share with the... (shrink)

The discrepancy between syntax and semantics is a painstaking issue that hinders a better comprehension of the underlying neuronal processes in the human brain. In order to tackle the issue, we at first describe a striking correlation between Wittgenstein's Tractatus, that assesses the syntactic relationships between language and world, and Perlovsky's joint language-cognitive computational model, that assesses the semantic relationships between emotions and “knowledge instinct”. Once established a correlation between a purely logical approach to the language and computable (...) psychological activities, we aim to find the neural correlates of syntax and semantics in the human brain. Starting from topological arguments, we suggest that the semantic properties of a proposition are processed in higher brain's functional dimensions than the syntactic ones. In a fully reversible process, the syntactic elements embedded in Broca's area project into multiple scattered semantic cortical zones. The presence of higher functional dimensions gives rise to the increase in informational content that takes place in semantic expressions. Therefore, diverse features of human language and cognitive world can be assessed in terms of both the logic armor described by the Tractatus, and the neurocomputational techniques at hand. One of our motivations is to build a neuro-computational framework able to provide a feasible explanation for brain's semantic processing, in preparation for novel computers with nodes built into higher dimensions. (shrink)

The goal of this article is to review some aspects of brain anatomy and neurophysiology that are important for consciousness, and which hopefully may be of benefit to philosophers investigating the conscious mind. Taking as an initial point of reference the distinction between “the hard problem” and “the weak problems” of consciousness, we shall concentrate on questions pertaining to the second of these. A putative “consciousness system” in the brain will be presented, paying special attention to diffuse projection (...) systems. The “center of gravity” will be brain connectivity, since consciousness must, critically, be dependent on coherent activity and timing. “Detectors” of synchronicity and coincidence, like NMDA receptors, also necessarily play a role here. To be conscious, we do not need an entire brain. While even large hemispherectomies need not unequivocally affect consciousness, far smaller brain-stem lesions may be devastating in this regard. Even so, the recent discovery by Matthew F. Glasser et al. of 180 separate areas in the human brain cortex is intriguing from a teleological perspective, as it is quite unthinkable that any of them could be “redundant. (shrink)

It is now a common belief that the truths of our lives are hidden in the databases streamed from our interactions in smart environments. In this current hype of big data, the Internet of Things has been suggested as the idea to embed small sensors and actuators everywhere to unfold the truths beneath the surfaces of everything. However, remaining the technology that promises more than it can provide thus far, more important for the IoT’s actual expansion to various social domains (...) than the actual discovery of hidden truths has been people’s speculations about the unknown problems, such as hidden security issues or lifestyle concerns, beyond the narrow human knowability but assumed to leave their traces in the IoT-collected big data. This paper discuss this speculation as the concealed cognitive labor of IoT users that projects some fictitious values to the big data IoT companies accumulate. By the term pan-kinetics, the systemic operation of smart actuators is analyzed as the process through which fictitious values of data are converted to the real values as these actuators draw some profitable correlations from physical domains of the IoT. Analyzing smart electroencephalogram headsets as the unique IoT devices operating on human brains, it argues how the IoT translates this speculative realism of unknown problems into its big data, which the IoT developers believe to be full of machine-learnable correlations that would lead to the smart solutions of the problems. (shrink)

BackgroundTo probe the functional role of brain oscillations, transcranial alternating current stimulation has proven to be a useful neuroscientific tool. Because of the excessive tACS-caused artifact at the stimulation frequency in electroencephalography signals, tACS + EEG studies have been mostly limited to compare brain activity between recordings before and after concurrent tACS. Critically, attempts to suppress the artifact in the data cannot assure that the entire artifact is removed while brain activity is preserved. The current study aims (...) to evaluate the feasibility of specific artifact correction techniques to clean tACS-contaminated EEG data.New MethodIn the first experiment, we used a phantom head to have full control over the signal to be analyzed. Driving pre-recorded human brain-oscillation signals through a dipolar current source within the phantom, we simultaneously applied tACS and compared the performance of different artifact-correction techniques: sine subtraction, template subtraction, and signal-space projection. In the second experiment, we combined tACS and EEG on one human subject to demonstrate the best-performing data-correction approach in a proof of principle.ResultsThe tACS artifact was highly attenuated by SSP in the phantom and the human EEG; thus, we were able to recover the amplitude and phase of the oscillatory activity. In the human experiment, event-related desynchronization could be restored after correcting the artifact.Comparison With Existing MethodsThe best results were achieved with SSP, which outperformed sine subtraction and template subtraction.ConclusionOur results demonstrate the feasibility of SSP by applying it to a phantom measurement with pre-recorded signal and one human tACS + EEG dataset. For a full validation of SSP, more data are needed. (shrink)

In this article, we present and analyse the concept of Digital Twin linked to distinct types of objects and examine the challenges involved in creating them from a fundamental neuroethics approach that emphasises conceptual analyses. We begin by providing a brief description of DTs and their initial development as models of artefacts and physical inanimate objects, identifying core challenges in building these tools and noting their intended benefits. Next, we describe attempts to build DTs of model living entities, such as (...) hearts, highlighting the novel challenges raised by this shift from DTs of inanimate to DTs of living objects. Against that background, we give an account of contemporary research aiming to develop DTs of the human brain by building "virtual brains", e.g. the simulation engine The Virtual Brain as it is carried out in the European Human Brain Project. Since the brain is structurally and functionally the most complex organ in the human body, and our integrated knowledge of its functional architecture remains limited in spite of recent neuroscientific advances, the attempts to create virtual copies of the human brain are correspondingly challenging. We suggest that a clear scientific theoretical structure, conceptual clarity and transparency regarding the methods and goals of this technological development are necessary prerequisites in order to make the project of constructing virtual brains a theoretically promising and socially beneficial scientific, technological and philosophical enterprise. (shrink)

Whole Brain Emulation has been championed as the most promising, well-defined route to achieving both human-level artificial intelligence and superintelligence. It has even been touted as a viable route to achieving immortality through brain uploading. WBE is not a fringe theory: the doctrine of Computationalism in philosophy of mind lends credence to the in-principle feasibility of the idea, and the standing of the Human Connectome Project makes it appear to be feasible in practice. Computationalism is (...) a popular, independently plausible theory, and Connectomics a well-funded empirical research program, so optimism about WBE is understandable. However, this optimism may be misplaced. This article argues that WBE is, at best, no more compelling than any of the other far-flung routes to achieving superintelligence. Similarly skeptical conclusions are found regarding immortality. The essay concludes with some positive considerations in favor of the Biological Theory of consciousness, as well as morals about the limits of Computationalism in both artificial intelligence and the philosophy of mind more generally. (shrink)

Many Big Science projects and networks experience conflict. A plethora of disciplines have examined conflict causes in science collaboration and Big Science, contributing to a more nuanced understanding of why conflicts emerge. Yet, so far, there is no theoretical model that explains which mechanisms connect conflict cause and outbreak in Big Science. Drawing on interdisciplinary literature on science collaboration and Big Science as well as on scholarship on strategic action fields (SAFs), I address this blind spot by proposing a model (...) that outlines which mechanisms induce and fuel conflict in Big Science projects and networks. Five interlinked mechanisms – attribution of threat or opportunity, mobilization of resources, coalition-building, boundary deactivation and innovative action – are central to it. Tracing these mechanisms in conflictual episodes which emerged in three typical, yet most-different, Big Science cases – the International Experimental Thermonuclear Reactor (ITER), the Human Brain Project (HBP) and the Thirty Meter Telescope (TMT) – this study also provides a proof of concept for the model. (shrink)

The natural sciences seek to explain all natural phenomena, including human beings. This lofty objective encompasses the scientific project in all its glory, within which brain science constitutes an integral part. Essentially, however, neuroscientists not only seek to achieve a greater understanding of how the human brain works but rather, and perhaps mainly, aspire to understand human consciousness, that is, the subjective experience. According to this approach, consciousness is merely brain activity, and thus (...) any progress in the study of the brain represents an advance in the study of consciousness. Yet, despite the many and impressive neuroscientific achievements, when it comes to understanding human consciousness, this discipline cannot deliver the goods. This ongoing failure, so it will be suggested, arouses uncanny anxiety, largely because consciousness is the only phenomenon in which we have complete confidence. The present article suggests that in order to advance our understanding of the subjective experience, we must focus on how the body is thrown into the world in the here-and-now. (shrink)

The judgement of human ability is ubiquitous, from school admissions to job performance reviews. The exact make-up of ability traits, however, is often narrowly defined and lacks a comprehensive basis. We attempt to simplify the spectrum of human ability, similar to how five personality traits are widely believed to describe most personalities. Finding such a basis for human ability would be invaluable since neuropsychiatric disease diagnoses and symptom severity are commonly related to such differences in performance. Here, (...) we identified four underlying ability traits within the National Institutes of Health Toolbox normative data (n= 1, 369): (1) Motor-endurance, (2) Emotional processing, (3) Executive and cognitive function, and (4) Social interaction. We used the Human Connectome Project young adult dataset (n= 778) to show that Motor-endurance and Executive and cognitive function were reliably associated with specific brain functional networks (r2= 0.305 ± 0.021), and the biological nature of these ability traits was also shown by calculating their heritability (31 and 49%, respectively) from twin data. (shrink)

In recent years, neuroscience has been a particularly prolific discipline stimulating many innovative treatment approaches in medicine. However, when it comes to the brain, new techniques of intervention do not always meet with a positive public response, in spite of promising therapeutic benefits. The reason for this caution clearly is the brain’s special importance as “organ of the mind”. As such it is widely held to be the origin of mankind’s unique position among living beings. Likewise, on the (...) level of the individual human being, the brain is considered the material substrate of those traits that in combination render each person unique. In view of this preeminent significance of the brain, it is understandable that, in general, interventions into the brain are considered a delicate issue and that new techniques of intervention are scrutinised with particular care. However, in doing so it is important not to go to the opposite extreme and shy away from promising new therapeutic approaches for debilitating disorders of the brain. With respect to the new techniques of brain intervention a broad interdisciplinary perspective is required to discern irrational fear from justified concern. Hence, the Europäische Akademie established a project group consisting, on the one hand, of experts from different fields of medicine who have got first-hand experience of applying the techniques at issue and, on the other hand, of philosophers and a legal expert. The task of this team was to review the state of the art with respect to each single technique of intervening in the brain, to indicate future developments, and to address the ethical and legal issues common to all of them. The project’s outcome is the book at hand. (shrink)

Increasingly, national governments across the globe are prioritizing investments in neuroscience. Currently, seven active or in-development national-level brain research initiatives exist, spanning four continents. Engaging with the underlying values and ethical concerns that drive brain research across cultural and continental divides is critical to future research. Culture influences what kinds of science are supported and where science can be conducted through ethical frameworks and evaluations of risk. Neuroscientists and philosophers alike have found themselves together encountering perennial questions; these (...) questions are engaged by the field of neuroethics, related to the nature of understanding the self and identity, the existence and meaning of free will, defining the role of reason in human behavior, and more. With this Perspective article, we aim to prioritize and advance to the foreground a list of neuroethics questions for neuroscientists operating in the context of these international brain initiatives. (shrink)

Brain Computer Interface (BCI) technology offers potential for human augmentation in areas ranging from communication to home automation, leisure and gaming. This paper addresses ethical challenges associated with the wider scale deployment of BCI as an assistive technology by documenting issues associated with the development of non-invasive BCI technology. Laboratory testing is normally carried out with volunteers but further testing with subjects, who may be in vulnerable groups is often needed to improve system operation. BCI development is technically (...) complex, sometimes requiring lengthy recording sessions to achieve the necessary personalisation of the paradigms, and this can present ethical challenges that vary depending on the subject group. The paper contributes to the on-going ethical discussion surrounding the deployment BCI outside the specialist laboratory and suggests some tentative guidelines for BCI research teams, appropriate to those deploying the technology, derived from experience on a multisite project. Any tension between deployment and technical progress must be managed by a formal process within a multidisciplinary consortium. (shrink)

In _Neuroscience and Philosophy_ three prominent philosophers and a leading neuroscientist clash over the conceptual presuppositions of cognitive neuroscience. The book begins with an excerpt from Maxwell Bennett and Peter Hacker's _Philosophical Foundations of Neuroscience_ (Blackwell, 2003), which questions the conceptual commitments of cognitive neuroscientists. Their position is then criticized by Daniel Dennett and John Searle, two philosophers who have written extensively on the subject, and Bennett and Hacker in turn respond. Their impassioned debate encompasses a wide range of central (...) themes: the nature of consciousness, the bearer and location of psychological attributes, the intelligibility of so-called brain maps and representations, the notion of qualia, the coherence of the notion of an intentional stance, and the relationships between mind, brain, and body. Clearly argued and thoroughly engaging, the authors present fundamentally different conceptions of philosophical method, cognitive-neuroscientific explanation, and human nature, and their exchange will appeal to anyone interested in the relation of mind to brain, of psychology to neuroscience, of causal to rational explanation, and of consciousness to self-consciousness. In his conclusion Daniel Robinson (member of the philosophy faculty at Oxford University and Distinguished Professor Emeritus at Georgetown University) explains why this confrontation is so crucial to the understanding of neuroscientific research. The project of cognitive neuroscience, he asserts, depends on the incorporation of human nature into the framework of science itself. In Robinson's estimation, Dennett and Searle fail to support this undertaking; Bennett and Hacker suggest that the project itself might be based on a conceptual mistake. Exciting and challenging, _Neuroscience and Philosophy_ is an exceptional introduction to the philosophical problems raised by cognitive neuroscience. (shrink)

The completion of the human genome has given rise to a genre of mapping that enables scientists to explore biological life systems at a molecular level. Influenced by the human genome project, the human brain mapping project is underway with the goal in understanding the molecular basis of human cognition. In November 2002, scientists Daryl Macer and Masakazu Inaba developed a mental mapping project called the "human behaviourome" in order to map (...) the broad spectrum of human ideas. Although the aim of the human behaviourome is to understand the diversity of human ideas in given situations, it can be used in several ways and cross-cultural settings. This article explores some of the human behaviourome's potential uses. (shrink)

For millions of years, biological creatures have dealt with the world without being able to see it; however, the change in the atmospheric condition during the Cambrian period and the subsequent increase of light, triggered the sudden evolution of vision and the consequent evolutionary benefits. Nevertheless, how from simple organisms to more complex animals have been able to generate meaning from the light who fell in their eyes and successfully engage the visual world remains unknown. As shown by many psychophysical (...) experiments, biological visual systems cannot measure the physical properties of the world. The light projected onto the retina is, in fact, unable to specify the physical properties of the world in which humans and other visually ‘intelligent’ animals behave; however, visual behaviours are habitually successful. Through psychophysical evidence, examples of the functioning of Artificial Neural Networks and a reflection upon visual appreciation in the cultural and artistic context, this paper shows how vision emerged by random trial and error during evolution and lifetime learning; how the functioning of ANNs may provide evidence and insights on how machine and human vision works; and how rethinking vision theory in terms of trial and error may offer a new approach to better understand vision—biological and artificial—and reveal new insights into why we like what we like. (shrink)

This article explores Nicolas Malebranche's approach to fashion: an inescapable postlapsarian consequence of God's sociable design of the human mind and body as manifested in the imagination. A problematic side effect of the general laws established by God governing the soul-body relationship, fashion wreaked havoc on individuals' thinking and potential for redemption yet pointed to a larger providential plan for social benefit. These ideas led Malebranche to a distinctive nonpolitical approach to fashion—both “Enlightenment project” and theodicy—in which he (...) sought to promote, toward human liberation and salvation, an enlightened understanding of the processes that created fashion and a charitable approach to managing it. Ultimately, however, his brain-based analysis ended up limiting individual freedoms (imaginative, cognitive, and behavioral), notably for those endowed with certain kinds of minds, in ways that had long-lasting effect. It also helped lay foundations for the Enlightenment's conflicted views about fashion as individual folly and beneficial social phenomenon. -/- Cet article montre que, pour Nicolas Malebranche, la mode constitua une conséquence inévitable de la Chute et du dessin sociable et providentiel de l'esprit et du corps, manifesté dans l'imagination. Effet secondaire et problématique des lois générales établies par Dieu pour gouverner les relations entre l'esprit et le corps, la mode entrave la réflexion et l'accès au salut tout en dessinant un plan providentiel, au bénéfice de tous. A la fois projet des Lumières et théodicée, cette approche apolitique s'efforce, dans une visée mêlant libération, salut et charité, de saisir les processus qui créent la mode afin de s'en accommoder. Parce qu'elle met l'accent sur le cerveau, cette approche tend pourtant à restreindre, de manière durable, les libertés individuelles (imagination, cognition, comportement), surtout pour certains types d'esprit. Et elle montre comment, pour les Lumières, la mode peut être à la fois une folie individuelle et un phénomène à multiples vertus sociales. -/- Copyright 2022 by Society for French Historical Studies. (shrink)

Background: There is limited research on brain lesions in children with cerebral visual impairment of heterogeneous etiologies and according to associated subtyping and vision dysfunctions. This study was part of a larger project establishing data-driven subtypes of childhood CVI according to visual dysfunctions. Currently there is no consensus in relation to assessment, diagnosis and classification of CVI and more information about brain lesions may be of potential diagnostic value.Aim: This study aimed to investigate overall patterns of (...) class='Hi'>brain lesions and associations with level of visual dysfunction and to compare the patterns between the classification subgroups in children with CVI.Methods: School-aged children with CVI received ophthalmological and neuro-psychological/developmental assessments to establish CVI-related subtyping. Other pediatric information was collected from medical records. MRI scans were coded according to a semi-quantitative template including brain regions and summed for total scores. Non-parametric analyses were conducted.Results: 28 children had clinical brain MRI scans available [44% of total sample, Group A n = 16, Group B n = 12]. Total brain scores ranged between 0 and 18 and were widespread across regions. 71 per cent had post-geniculate visual pathway damage. The median total brain and hemisphere scores of Group B were higher than subgroup A but differences did not reach statistical significance. No statistically significant associations were found between brain scores and vision variables.Conclusion: This study found a spread of lesions across all regions on the brain scans in children with congenital CVI. The majority had damage in the postgeniculate visual pathways and visual cortex region suggesting this is an area of interest and potentially informative for diagnosis. However the subtyping classification did not show differences in number or region of lesions though the trend was higher toward Group B. This study confirms the complex diffuse and variable nature of brain lesions in children with congenital CVI, many of whom have other neurological impairments. (shrink)

Strange inversions occur when things work in ways that turn received wisdom upside down. Hume offered a strangely inverted story about causation, and Darwin, about apparent design. Dennett suggests that a strange inversion also occurs when we project our own reactive complexes outward, painting our world with elusive properties like cuteness, sweetness, blueness, sexiness, funniness, and more. Such properties strike us as experiential causes, but they are really effects—a kind of shorthand for whole sets of reactive dispositions rooted in (...) the nuts and bolts of human information processing. Understanding the nature and origins of that strange inversion, Dennett believes, is thus key to understanding the nature and origins of human experience itself. This paper examines this claim, paying special attention to recent formulations that link that strange inversion to the emerging vision of the brain as a Bayesian estimator, constantly seeking to predict the unfolding sensory barrage. (shrink)

A timely and uniquely compelling plea for the importance of nurture in the ongoing nature-nurture debate. In this era of genome projects and brain scans, it is all too easy to overestimate the role of biology in human psychology. But in this passionate corrective to the idea that DNA is destiny, Jesse Prinz focuses on the most extraordinary aspect of human nature: that nurture can supplement and supplant nature, allowing our minds to be profoundly influenced by experience (...) and culture. Drawing on cutting-edge research in neuroscience, psychology, and anthropology, Prinz shatters the myth of human uniformity and reveals how our differing cultures and life experiences make each of us unique. Along the way he shows that we can’t blame mental illness or addiction on our genes, and that societal factors shape gender differences in cognitive ability and sexual behavior. A much-needed contribution to the nature-nurture debate, Beyond Human Nature shows us that it is only through the lens of nurture that the spectrum of human diversity becomes fully and brilliantly visible. (shrink)

The article deals with the philosophical problem field of modern neuroethics. The general idea of the state of modern neuroethics is given and it is shown that research in this area encompasses both fundamental problems that classically belonged to the field of philosophy research (for example, such as the problem of psychophysical dualism, the physical bases of consciousness, freedom of will and its interrelation with brain activity) and problems with applied orientation, explicating the ethical-social and legal dimension of innovation (...) development in the field of neuroscience and actualizing the analysis of their social risks. It is shown that the development of neuro-ethics in the modern world became possible thanks to a special way of functioning of modern science, which was called the technology of science and to the development of the phenomenon of technological development ethification, which in practical terms was expressed in the study of the problem of the correspondence of the results of innovative scientific and technical projects to the interests of various social groups, their expectations and values, and also helped to determine the status of new technologies in relation to social reality. The article gives an idea of the existing normative field necessary for the development of neuro-ethics. On the basis of using the resource of discourse analysis of R. Harre, who singled out personal grammar (P-grammar), organism grammar (O-grammars) and molecular grammar (M-grammar), a philosophical analysis of such a problem of modern neuroethics as brain death was carried out. Also was given a structural description of new biotechnogenic identities of human being. The conclusion is drawn that the concept of brain death is an example of the conventional nature of scientific truth, the formation of which is influenced by various socio-cultural and economic factors. In the context of the development of neuroscience and the emergence of new methods of brain regeneration, it can be rethought. (shrink)

Based on a short presentation of the unexplained relation of brain and consciousness, the mereological fallacy is addressed as a main point of criticism on typical, especially materialistic attempts of solution. Facing the risk of an unrefected mixing of different descriptive levels, purified phenomenologies of brain and consciousness have to be elaborated. Comparing the analytical results, not only incommensurable aspects but also superordinated structure factors can be shown which allow us to formulate a first featurebased relation. Because this (...) interim result does not disclose any evidence for a neurally based constitution of consciousness, an investigation of the structure-phenomenology of Herbert Witzenmann is embarked on as an intrinsic approach to consciousness research. Spurred on by cognitive borderline situations, this approach is motivated and elucidated referring to its method and outcome. Following its path, it becomes possible to interpret certain findings of neuroscience and systematic self-observation in the sense of cross-border effects and to establish a trans-categorical correlation in the context of logical constitution. This innovative concept of correlations is illustrated by aspects of rhythmicity, topology and plasticity. The attempt to position structure-phenomenology between monism and dualism leads to a dynamic integration of this polarity. Implications for human constitution and philosophy are sketched shortly. Finally, an outlook is given on possible projects of trans-disciplinary research. (shrink)

English Title: "The ethical and educative potential of Kathinka Evers's proactive epigensis" Resumen: La profesora Kathinka Evers es una de las coordinadoras del área filosófica relativa a la conciencia del Human Brain Project (HBP). Basándose en trabajos de neurociencia, biología y filosofía, su propuesta de epigénesis proactiva mantiene que existe una simbiogénesis cultural inevitable, en la que el ser humano está influido en su carácter y comportamiento por los genes de la misma forma en que con sus (...) acciones y su comportamiento puede influir a la larga en las variaciones genéticas de generaciones posteriores. El objetivo de este trabajo es analizar su propuesta para dar cuenta de la importancia de la ética y la educación en el seno de la cultura, frente a las visiones más reduccionistas y materialistas de la neuroética. Abstract: Professor Kathinka Evers is one of the coordinators of the philosophy area concerning consciousness of the Human Brain Project (HBP). Based on works in neuroscience, biology and philosophy, her proactive epigenesis proposal maintains that there is an inevitable cultural symbiogenesis in which genes have influence on human character and behavior in the same way as human actions and behavior can influence genetic variations in subsequent generations. The aim of this paper is to analyze this proposal in order to account for the importance of ethics and education in culture, and opposing more materialistic and reductionist views of neuroethics. Palabras clave: epigénesis proactiva, simbiogénesis cultural, neuroética, ética. Keywords: proactive epigenesis, cultural simbiogenesis, neuroethics, ethics. (shrink)