The principle of informed consent obligates physicians to explain possible side effects when prescribing medications. This disclosure may itself induce adverse effects through expectancy mechanisms known as nocebo effects, contradicting the principle of nonmaleficence. Rigorous research suggests that providing patients with a detailed enumeration of every possible adverse event—especially subjective self-appraised symptoms—can actually increase side effects. Describing one version of what might happen (clinical “facts”) may actually create outcomes that are different from what would have happened without this information (another (...) version of “facts”). This essay argues that the perceived tension between balancing informed consent with nonmaleficence might be resolved by recognizing that adverse effects have no clear black or white “truth.” This essay suggests a pragmatic approach for providers to minimize nocebo responses while still maintaining patient autonomy through “contextualized informed consent,” which takes into account possible side effects, the patient being treated, and the particular diagnosis involved. (shrink)

No one really believes that literally all functions of the entire brain must be lost for an individual to be dead. A better definition of death involves a higher brain orientation.

Individualists like to think of themselves as atoms, their trajectories causally dependent on collisions with other similar entities but their essence resolutely independent and autonomous. They are whole and entire in themselves: they are not elements or adjuncts of some greater whole. Collectivists take an opposite view. Their oddities and accidents may be individual and independent, their movements and machinations largely self-determined, but in their essence they are necessarily bound to others – for all are adjuncts and elements (...) of a larger whole. In this essay I discuss one version of the collectivist philosophy, a version which has been as popular and as widely supported as any philosophy of human nature. In Section I, the constituent ideas are expounded, largely by way of citation from Alexander Pope. In Section II, the anthropological aspect of Pope's philosophy is subjected to scrutiny; and in Section III, the axiological side of the theory is examined. (shrink)

This chapter examines five emulation methods, drawing a distinction between structure replication and reconstruction (SR) methods, and reverse brain engineering (RBE) methods. It argues that we need reasons to claim a particular procedure does or does not maintain identity, independently of whether the procedure is destructive or nondestructive. The chapter proposes that whole brain emulation (WBE) research be aimed primarily at cybernetics and possibility of replacing a biological brain in steps that involve very small parts with no psychologically relevant (...) structure. It also argues that methods reliant on structure replication and reconstruction will not preserve personal identity, based on a neo‐Lockean definition of personal identity according to which the self is a relatively autonomous self‐perpetuating substance whose psychological continuity through time is ensured primarily by immanent causation. All SR methods involve too much transeunt causation. (shrink)

I borrow an idea from the fiction of C. S. Lewis that future outcomes may affect the value of past events, defend this idea via the concept of a 'temporal whole' and show its promise as a part of a theodicy and its resonance with Christian theism.

Ontic structural realism argues that structure is all there is. In (French, 2014) I argued for an ‘eliminativist’ version of this view, according to which the world should be conceived, metaphysically, as structure, and objects, at both the fundamental and ‘everyday’ levels, should be eliminated. This paper is a response to a number of profound concerns that have been raised, such as how we might distinguish between the kind of structure invoked by this view and mathematical structure in general, how (...) we should choose between eliminativist ontic structural realism and alternative metaphysical accounts such as dispositionalism, and how we should capture, in metaphysical terms, the relationship between structures and particles. In developing my response I shall touch on a number of broad issues, including the applicability of mathematics, the nature of representation and the relationship between metaphysics and science in general. (shrink)

A scientific explanatory project, part-whole explanation, and a kind of science, part-whole science are premised on identifying, investigating, and using parts and wholes. In the biological sciences, mechanistic, structuralist, and historical explanations are part-whole explanations. Each expresses different norms, explananda, and aims. Each is associated with a distinct partitioning frame for abstracting kinds of parts. These three explanatory projects can be complemented in order to provide an integrative vision of the whole system, as is shown for (...) a detailed case study: the tetrapod limb. My diagnosis of part-whole explanation in the biological sciences as well as in other domains exploring evolved, complex, and integrated systems (e.g., psychology and cognitive science) cross-cuts standard philosophical categories of explanation: causal explanation and explanation as unification. Part-whole explanation is itself one essential aspect of part-whole science. (shrink)

The centrality of the whole/part relation in mathematics is demonstrated through the presentation and analysis of examples from algebra, geometry, functional analysis,logic, topology and category theory.

Kant often compares reason to an organized body, which suggests that reason should be understood as a whole from which all possible uses of the faculties of reason are derived. However, Kant does not elaborate his conception of the whole of reason. Nor does the secondary literature. This paper suggests that the wholeness of reason is the apodictic modality of reason, i.e., the necessary standard that determines what can systematically belong to reason, and thus works as the systematic (...) condition for all possible uses of the faculties of reason. This necessary standard is the discipline of pure reason. Kant compare souvent la raison à un corps organisé, ce qui suggère que la raison devrait être comprise comme un tout à partir duquel dérivent systématiquement toutes les fonctions possibles des facultés de la raison. Ni Kant, ni la littérature secondaire n’élabore cependant sa conception de la raison comme un tout. Autrement dit, ils n’élaborent pas la notion d’unité de la raison. Je soutiens que l’unité de la raison devrait être comprise comme la modalité apodictique de la raison, c’est-à-dire le critère nécessaire qui détermine ce qui peut appartenir systématiquement à la raison. Ce critère nécessaire est la discipline de la raison pure. (shrink)

Implementing whole genome sequencing (WGS) in paediatric settings demands sensitive and nuanced examination. Critical reflection as to how and when to use this technology is particularly important. This commentary on Anderson et al's (2017) evaluation of the Genome Clinic study, which involved paediatric clinical WGS, provides an opportunity for such reflection. I scrutinise three issues raised in the study: (1) the non-separation of the choice over agreeing to diagnostic WGS and whether to receive adult-onset SVs; (2) the value of (...) deliberation regarding paediatric WGS and (3) the place of best interests in debates over returning adult-onset SVs. (shrink)

The use of genome-wide association studies in medical research and the increased ability to share data give a new twist to some of the perennial ethical issues associated with genomic research. GWAS create particular challenges because they produce fine, detailed, genotype information at high resolution, and the results of more focused studies can potentially be used to determine genetic variation for a wide range of conditions and traits. The information from a GWA scan is derived from DNA that is a (...) powerful personal identifier, and can provide information not just on the individual, but also on the individual's relatives, related groups, and populations. Furthermore, it creates large amounts of individual-specific digital information that is easy to share across international borders. This paper provides an overview of some of the key ethical issues around GWAS: consent, feedback of results, privacy, and the governance of research. Many of the questions that lie ahead of us in terms of the next generation sequencing methods will have been foreshadowed by GWAS and the debates around ethical and policy issues that these have created. (shrink)

The fact that the standard probabilistic calculus does not define probabilities for sentences with embedded conditionals is a fundamental problem for the probabilistic theory of conditionals. Several authors have explored ways to assign probabilities to such sentences, but those proposals have come under criticism for making counterintuitive predictions. This paper examines the source of the problematic predictions and proposes an amendment which corrects them in a principled way. The account brings intuitions about counterfactual conditionals to bear on the interpretation of (...) indicatives and relies on the notion of causal (in)dependence. (shrink)

Wholes, parts, form and powers Content Type Journal Article Category Book Review Pages 1-4 DOI 10.1007/s11016-011-9585-6 Authors Ruth Porter Groff, Department of Political Science, Saint Louis University, 3750 Lindell Blvd, St. Louis, MO 63108-3412, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

Whole genome sequencing is quickly becoming more affordable and accessible, with the prospect of personal genome sequencing for under $1,000 now widely said to be in sight. The ethical issues raised by the use of this technology in the research context have received some significant attention, but little has been written on its use in the clinical context, and most of this analysis has been futuristic forecasting. This is problematic, given the speed with which whole genome sequencing technology (...) is likely to be incorporated into clinical care. This paper explores one particular subset of these issues: the implications of adopting this technology in the prenatal context without a good understanding of when and how it is useful. Prenatal whole genome sequencing differs from current prenatal genetic testing practice in a number of ethically relevant ways. Most notably, whole genome sequencing would radically increase the volume and scope of available prenatal genetic data. The wealth of new data could enhance reproductive decision‐making, promoting parents' freedom to make well‐informed reproductive decisions. We argue, however, that there is potential for prenatal whole genome sequencing to alter clinical practice in undesirable ways, especially in the short term. We are concerned that the technology could (1) change the norms and expectations of pregnancy in ways that complicate parental autonomy and informed decision‐making, (2) exacerbate the deleterious role that genetic determinism plays in child rearing, and (3) undermine children's future autonomy by removing the option of not knowing their genetic information without appropriate justification. (shrink)

Restricted quantification poses a serious and under-appreciated challenge for nonclassical approaches to both vagueness and the semantic paradoxes. It is tempting to explain as ; but in the nonclassical logics typically used in dealing with vagueness and the semantic paradoxes (even those where thend expect. If we’re going to use a nonclassical logic, we need one that handles restricted quantification better.

Since the early 1980s, metonymy has progressively gained central stage in linguistic investigations. The advent of cognitive linguistics marked a new turn in the study of this trope conceived, not as a deviation from semantic conventions, but as a phenomenon rooted in non-language-specific mechanisms of conceptualization of the world. Acknowledging that metonymy is ultimately cognitive in nature, this paper proposes to consider metonymy from its multiple levels of manifestation, integrating cognitive, pragmatic, semantic, but also ontological angles of approach. Taking (...) class='Hi'>whole-for-part metonymies as a case study, I aim to show how recent developments within these respective disciplines can enrich our understanding of such metonymic mechanisms, sometimes without even identifying them as such. This paper proposes to establish a dialog between these disciplines on the topic of WP-metonymy. So, after a presentation of the most standard cognitive and pragmatic approaches to WP-metonymy, I will argue for the relevance of recent semantic investigations on quantity gradability, and for the theoretical importance of keeping these two kinds of part-reference clearly apart. I will show that the literature on gradability provides strong semantic arguments for doing so. Finally, connecting the debate on WP-metonymy with the ontological debate on property inherence will open the way for a formal treatment of WP-metonymy within ground logic. (shrink)

David Bohm was one of the foremost scientific thinkers and philosophers of our time. Although deeply influenced by Einstein, he was also, more unusually for a scientist, inspired by mysticism. Indeed, in the 1970s and 1980s he made contact with both J. Krishnamurti and the Dalai Lama whose teachings helped shape his work. In both science and philosophy, Bohm's main concern was with understanding the nature of reality in general and of consciousness in particular. In this classic work he develops (...) a theory of quantum physics which treats the totality of existence as an unbroken whole. Writing clearly and without technical jargon, he makes complex ideas accessible to anyone interested in the nature of reality. (shrink)

The rise of technologies that can inexpensively sequence entire genomes means that researchers and clinicians have access to ever vaster stores of genomic data, some of which could be of great use to research participants or patients, and most of which, at least for today, will be of little, uncertain, or no use. Those facts are essential features of a new ethical territory we are now entering with genetics research. As we explore that territory, we should try to be as (...) clear as possible about the issues at hand. Clarity about the ethical issues that delineate this new territory requires that we be wary about too hastily importing into it concepts from the old territory. We want to suggest a way in which the term “incidental findings” can impede our ability to see clearly some of the most important issues we face. To show how that term can sometimes obscure more than it illuminates, we focus on how it is being deployed in the context of research. Although it may have been useful, when considering older forms of genetic research, to speak about researchers stumbling across clinically significant findings, and although that way of speaking has certainly not yet become wholly obsolete, it is ever less appropriate as the technology becomes ever more powerful. (shrink)

Wholeness and Holiness guides us through a three-step journey to psychological soundness, spiritual wholeness, and saintly holiness. To attain this goal, a person must work at all three.

Clarke and Beck suggest that the ratio processing system may be a component of the approximate number system, which they suggest represents rational numbers. We argue that available evidence is inconsistent with their account and advocate for a two-systems view. This implies that there may be many access points for numerical cognition – and that privileging the ANS may be a mistake.

This chapter contains sections titled: The Trouble with “Truth” and “Truths” Problems with Partial Truth (and Some Vagaries of Vagueness).

Feel-feel-at-flesh-inside -- Our disabled sense -- Homo Ex Machina -- Stepping outside the story -- The grace of being -- Recovering holosapience -- When wholeness points the way -- A speleology of the body's intelligence.

I argue that Schaffer’s recent defence of Spinozan Monism—the thesis that the cosmos is the only substance, or the only fundamental and integrated thing— fails to establish that the universe is uniquely fundamental. In addition, Schaffer’s own defence of his thesis offers the pluralist about fundamentality a model for responding to Schaffer’s criticism of pluralism.

In this work, the author formulates a critique of widely accepted mereological assumptions, presents a new conception of wholes as ‘Unities’, and demonstrates the advantages of this new conception in treating a variety of metaphysical puzzles (such as that of Tibbles the cat). More generally he suggests that conceiving wholes as Unities offers us a new way of understanding the world in non-reductive terms.

Because Western experiments assume creativity is an individual phenomenon and rarely investigate how trust and openness might build collective resonance, flow, and creativity, the creative whole typically amounts to less than the sum of the parts. The author argues, however, that group creativity increases as members develop, especially through Wilber's (in press) transpersonal stages. He illustrates how organizational leaders have facilitated creativity through reflective practice. Presenting evidence regarding the field effects of collective consciousness, he suggests that our minds and (...) hearts interact in subtle yet powerful ways, which leaders can intuit, to support the emergence of collaborative creativity. (shrink)

In their cognitive theory of emotion, Schachter and Singer proposed that feelings are separable from what they are about. As a test, they induced feelings of arousal by injecting epinephrine and then molded them into different emotions. They illuminated how feelings in one moment lead into the next to form a stream of conscious experience. We examine the construction of emotion in a similar spirit. We use the sensory integration process to understand how the brain combines disparate sources of information (...) to construct both perceptual and emotional models of the world even as the world continues to change. We emphasize two processes: affect segmentation (isolating the felt component of an emotion) and affect integration (recombining this feeling with its object). (shrink)

Although the enactive approach has been very successful in explaining many basic social interactions in terms of embodied practices, there is still much work to be done when it comes to higher forms of social cognition. In this article, we discuss and evaluate two recent proposals by Shaun Gallagher and Daniel Hutto that try to bridge this ‘cognitive gap’ by appealing to the notion of narrative practice. Although we are enthusiastic about these proposals, we argue that (i) it is difficult (...) to see them as continuous with the enactivist notion of direct coupling, and (ii) the failure to account for folk psychological action interpretation suggests that the enactive approach should adopt a broader notion of coupling. (shrink)

In this book, the author defends the substantial unity of a human person whose life endures through time. Because a human being is an irreducible whole (including biological, psychological, and narrative powers), our lives can have personal coherence over time. The whole temporal expanse of a life is prior to any of its stages, just as a whole human person is prior to any of her organs or powers. We can tell stories about our past, present, and (...) future only because we possess a certain kind of complex unity at any one time. What we are as human beings makes it possible for us to lead the life of a human person. (shrink)

This report is grounded in several social concepts: First, the primary goal of genetic testing should be to promote the well-being of the child. Second, the recognition that children are part of a network of family relationships supports an approach to potential conflicts that is not adversarial but, rather, emphasizes a deliberative process that seeks to promote the child's well-being within this context. Third, as children grow through successive stages of cognitive and moral development, parents and professionals should be attentive (...) to the child's increasing interest and ability to participate in decisions about his or her own welfare. (shrink)

Whole body gestational donation offers an alternative means of gestation for prospective parents who wish to have children but cannot, or prefer not to, gestate. It seems plausible that some people would be prepared to consider donating their whole bodies for gestational purposes just as some people donate parts of their bodies for organ donation. We already know that pregnancies can be successfully carried to term in brain-dead women. There is no obvious medical reason why initiating such pregnancies (...) would not be possible. In this paper, I explore the ethics of whole-body gestational donation. I consider a number of potential counter-arguments, including the fact that such donations are not life-saving and that they may reify the female reproductive body. I suggest if we are happy to accept organ donation in general, the issues raised by whole-body gestational donation are differences of degree rather than substantive new concerns. In addition, I identify some intriguing possibilities, including the use of male bodies–perhaps thereby circumventing some potential feminist objections. (shrink)

States are believed to be the paradigmatic instances of legitimate political authority. But is their prominence justified? The classic concept of state sovereignty predicts the danger of a fatal deadlock among conflicting authorities unless there is an ultimate authority within a given jurisdiction. This scenario is misguided because the notion of an ultimate authority is conceptually unclear. The exercise of authority is multidimensional and multiattributive, and to understand the relations among authorities we need to analyse this complexity into its different (...) aspects. Instead of ultimate authorities we can have actors endowed with superior authority over others in one regard, but not necessarily in another. And this limited superiority is sufficient for resolving conflicts. There is no need for ultimate authorities. Having discarded the notion of sovereignty we can embrace a different conception of legitimate authority, one that is not interested in the pedigree of actors, but in their capacity to serve its subjects. If states wish to retain their central role in the domain of political authority, they will have to earn it. (shrink)

Part–whole relations are pervasive throughout domain ontologies and enjoy interest also in, inter alia, NLP and manufacturing, and by philosophers in the scope of mereology. There exist a stable li...

In the last decade it has become en vogue for cognitive comparative psychologists to study animal behavior in an ‘integrated’ fashion to account for both the ‘innate’ and the ‘acquired’. We will argue that these studies, instead of really integrating the concepts of ‘nature’ and ‘nurture’, rather cement this old dichotomy. They combine empty nativist interpretation of behavior systems with blatantly environmentalist explanations of learning. We identify the main culprit as the failure to take development seriously. While in some areas (...) of biology interest in the relationship between behavior and development has surged through topics such as extragenetic inheritance, niche construction, and phenotypic plasticity, this has gone almost completely unnoticed in the study of animal behavior in comparative psychology, and is frequently ignored in ethology too. The main aims of this paper are to clarify the relationship between the concepts of learning, experience, and development, and to investigate whether and how all three concepts can be usefully deployed in the study of animal behavior. This will require the full integration of the psychological study of behavior into biology, and of the idea of learning into a wider concept of experience. We lay out how, in a systems view of development, learning may just appear as one among many processes in which experience influences behavior. This new synthesis should help to overcome the age-old dualism between innate and acquired. It thereby opens up the possibility of developing scientifically more fruitful distinctions. (shrink)

This chapter reconstructs the account of the organization of unified definite manifolds that Husserl developed in his early logic of parts and wholes. I argue that Husserl’s conception of necessity gets fixed through the logic of fitness that is operative in his account of unified definite manifolds that are organized by symmetrical part/whole relations. Husserl’s logical account of necessity finds its ultimate justification in his theory of intentionality and is operative in his phenomenological methodology generally. Through this conception of (...) necessity of the way in which manifolds are unified and organized, Husserl radicalized and exploded the Kantian conception of the material a priori and distinguished among several kinds of a priori, e.g., the correlational a priori, a priori bound to the empirical, and pure material a priori. Husserl’s phenomenological account of the material a priori further clarifies the important differences with Kant’s approach to the problem of necessity. (shrink)

What it is to be an object and what it is to be a whole are separate enterprises: answering the former is doing ontology, and answering the latter is not. By providing this distinction, a new metaphysics of objects emerges. The positing of a whole is a referential gesture, either by ostension or naming, and the alleged object is postulated without consideration of internal causal operations between its parts. An object, however, requires careful physical explanation. I explicate the (...) concept of object as an ontological function which takes mereological sums as arguments, and by causal operations on the members of that sum as structural relata, returns holistic properties of a singular entity. With the revised notions of whole and object in mind, I consider what implications this bears on existential quantification. Following Meinong, I believe that the existential quantifier does not capture existence. Instead, I argue that the existential quantifier expresses a mereological notion of countability; the collecting of things as one. The existential status of a counted entity is left unstated until it is explicitly asserted as existing by a speaker, in the mental frame of a realist attitude, and this expression of existence is captured by the existence predicate. The existence of the counted entity, the alleged object, is confirmed or denied as an object in light of whether it satisfies the conditions specified by an endorsed theory of causally productive relations; the conditions under which something is an object. (shrink)