The process of antigenic variation in parasitic African trypanosomes is a remarkable mechanism for outwitting the immune system of the mammalian host, but it requires a delicate balancing act for the monoallelic expression, folding and transport of a single variant surface glycoprotein (VSG). Only one of hundreds of VSG genes is expressed at time, and this from just one of ≈15 dedicated expression sites. By switching expression of VSGs the parasite presents a continuously shifting antigenic facade leading (...) to prolonged chronic infections lasting months to years. The basics of VSG structure and switching have been known for several decades, but recent studies have brought higher resolution to many aspects this process. New VSG structures, in silico modeling of infections, studies of VSG codon usage, and experimental ablation of VSG expression provide insights that inform how this remarkable system may have evolved. (shrink)

African trypanosomes, which cause sleeping sickness in man and other mammals, are able to evade immune destruction in their hosts by altering the expression of a major cell surface molecule, the variant surface glycoprotein (VSG). The VSGs are encoded by a multigene family, and antigenic variation occurs when the trypanosome switches from expression of one VSG gene to another. This switching process involves changes in the arrangement of the trypanosome genomic DNA.

Thy‐1 is a small glycoprotein of 110 amino acids which, folded in the characteristic structure of an immunoglobulin variable domain1, are anchored to the plasma membrane via a glycophosphatidylinositol (GPI) tail(2,3) (Fig. 1). It is a major component of the surface of various cell types, including neurons, at certain stages of their development (4). These qualities doubtlessly appeal to certain cognoscenti, but it is not clear why they would raise Thy‐1 to the status of a favourite molecule. Indeed, (...) few scientists readily admit to having a favourite. We study individual molecules because science is rooted in specific observations; but we do so in order to discover mechanisms of general importance. A molecule's appeal is dependent on its ability to reveal novel aspects of how nature works.Thy‐1 has been unusual in this respect. It was the first lymphocyte surface antigen shown to be restricted to a functional subset of lymphocytes (T cells in the mouse), a finding crucial to the development of cellular immunology(5); it was one of the first cell surface molecules to be sequenced and indicated the importance of immunoglobulin domains and GPI anchors as structural motifs(1–3); it has been pivotal in studies demonstrating that GPI‐anchored molecules are able to signal across the membrane they do not span(6, 7). Thy‐1 has revealed this much, however, with the charm of an adroit stripper: it has always promised glimpses of things more exciting than that displayed. In particular, the function of this molecule has never emerged.Our current work on Thy‐1 in the nervous system is, we believe, finally prizing this last secret into the open. It suggests that Thy‐1 on the neuronal surface interacts with one of the main glial types of adult brain, the astrocyte, to restrict axonal growth(8). There is no current consensus that astrocytes do regulate such growth, and this is the wider question we are addressing from the perspective of Thy‐1. At issue also is how to progress from knowing the nature of a molecule to defining its function. This task has already been achieved with molecules which were harder to characterise than Thy‐1. The problem is a classic Catch 22 situation: Thy‐1 has been readily characterised because it is small and abundant it is ten times more abundant than any other surface glycoprotein on rat thymocytes(9); but since there is so much of it, whatever it does it must do rather badly (or there would be no need to have so much of it!). Defining a function based on low activity or affinity is not trivial.Here I describe two aspects of work on Thy‐1. One is long completed ‐ the research which led to Thy‐1 being isolated and characterised ‐ and included because it demonstrates features which are still applicable to much research using a antibodies today. The other is our ongoing work on the nervous system, which is at that exciting early stage where hypotheses are formed, but the answers are still coming in. (shrink)

The finding that people tend to prefer logically valid conclusions over invalid ones is known in the literature as the logic‐liking effect and has traditionally been interpreted as evidence for the notion of so‐called logical intuitions. Results of more recent empirical studies investigating conditional and categorical syllogisms suggest, however, that previous instances of the logic‐liking effect can be accounted for by a confound in terms of surface‐feature atmosphere. But the true nature of this atmosphere effect has so far remained (...) largely elusive. Here, we address this issue and introduce two variants of disjunctive syllogisms that enable us to deconfound validity, possibility of the conclusion, and surface‐feature atmosphere, which has been impossible with simple disjunctive syllogisms used in earlier studies. Three experiments, in which participants were asked to provide liking and logic ratings for these arguments, revealed that the logic‐liking effect in disjunctive syllogisms can be explained by an atmosphere confound in combination with implied demand to consider logicality when judging likability. We also observed a strong atmosphere effect in logic ratings over and above an effect of logical validity per se. Furthermore, atmosphere effects appear to be induced only by specific surface features, namely those that are ecologically valid, if fallible, predictors for logicality. We conclude that acquired atmosphere heuristics provide proxies for logical validity that reasoners often take at face value. A comparison of the present results with previous findings from experiments that focused on conditional and categorical syllogisms additionally indicates that these atmosphere heuristics are used irrespective of an argument's complexity. (shrink)

The distribution of the flap allophone [ɾ] of American English, along with the other allophones of /t/,[t h,t =, ʔ, t] has been accounted for in various formal frameworks by assuming a number of different abstract mechanisms and entities. The desirability or usefulness of these formalisms is not at issue in the present paper. Instead, a computationally explicit model of categorization is used (Skousen 1989, 1992) in order to account for the distribution of the allophones of /t/ without recourse to (...) such formalisms. The simulations that were carried out suggest that they are not needed because analogy to surface apparent variables such as phones and word boundaries is sufficient to predict allophony. In analogy, the particular allophone of /t/ (i.e. [ɾ, t h, t =, ʔ, t]) that appears in a given context is determined on the basis of similarity to stored exemplars in the mental lexicon. From an acquisitional standpoint, categorization by analogy to stored exemplars dispenses with the need for rule induction although it does suggest that speakers group functionally related sounds into mental categories, a process that is influenced to a great deal by orthography. Analogy also explains the stochastic nature of linguistic performance. In the present study, 3,719 tokens of the allophones of the phoneme /t/ were extracted from the TIMIT corpus and constitute the database from which analogs were chosen. The variables used included the three phones or boundaries on either side of /t/, and the stress of the syllables preceding and following /t/. The model proves quite successful in predicting the correct allophone, and the errors made are generally possible alternative pronunciations (e.g. moun[ʔ]ain, moun[t h ]ain). The success rate changes little when only small sub-samples of the database are incorporated. In addition, exemplar-modeling is found to be quite robust because even when a feature such as stress is eliminated, (a feature which is critical in most rule approaches), allophony is still highly predictable. (shrink)

The Drosophila position‐specific antigens are a family of cell‐surface glycoprotein complexes showing spatially restricted patterns of expression. Changes in these distributions correlate with morphogenetic events like compartment‐alization and the formation of grooves and folds during tissue organization. The complexes each contain a common component associated with different variable components. Different tissues, organs and regions of the body express complexes containing different subsets of variable components. The structure of the complexes resembles that of the family of vertebrate receptors for (...) fibronectin, molecules which function in morphogenetic processes involving cell migration and attachment. It is possible that the position‐specific antigens have a similar role in fly development. (shrink)

Microfilament interactions with the plasma membranes of animal cells appear to vary with cell type and localization. In the erythrocyte, actin oligomers are associated with the membrane via spectrin and ankyrin. The ends of stress fibers in cultured cells, such as fibroblasts, are attached to the plasma membrane at focal adhesion sites and may involve the protein vinculin as a linking protein. In intestinal brush border microvilli a 110,000 dalton protein links the microfilament bundles to sites on the microvillus. A (...) transmembrane complex containing actin stably associated with a cell surface glycoprotein can be isolated from ascites tumor cell microvilli and can be obtained still associated with microfilaments by gentle extraction and gradient centrifugation of the microvilli. These varied interaction mechanisms are believed to be needed to satisfy the different structural and dynamic requirements of the particular systems. (shrink)

Multicellularity in the cellular slime mold Dictyostelium discoideum is achieved by the expression of two types of cell–cell adhesion sites. The EDTA‐sensitive adhesion sites are expressed very early in the developmental cycle and a surface glycoprotein of 24000 Da is known to be responsible for these sites. The EDTA‐resistant contact sites begin to accumulate on the cell surface at the aggregation stage of development. Several glycoproteins have been implicated in the EDTA‐resistant type of cell–cell binding and the (...) best characterized one has an Mr of 80000 (gp80). gp80 mediates cell–cell binding via homophilic interaction and its cell binding site has been mapped to an octapeptide sequence. The mechanism by which gp80 mediates cell–cell adhesion will be discussed. (shrink)

A number of recent studies have examined the effects of phonological variation on the perception of speech. These studies show that both the lexical representations of words and the mechanisms of lexical access are organized so that natural, systematic variation is tolerated by the perceptual system, while a general intolerance of random deviation is maintained. Lexical abstraction distinguishes between phonetic features that form the invariant core of a word and those that are susceptible to variation. Phonological inference relies on the (...) context of surface changes to retrieve the underlying phonological form. In this article we present a model of these processes in speech perception, based on connectionist learning techniques. A simple recurrent network was trained on the mapping from the variant surface form of speech to the underlying form. Once trained, the network exhibited features of both abstraction and inference in its processing of normal speech, and predicted that similar behavior will be found in the perception of nonsense words. This prediction was confirmed in subsequent research (Gaskell & Marslen-Wilson, 1994). (shrink)

Phonemes have variant pronunciations depending on context. For instance, in American English, the [t] in pat [pæt] and the [d] in pad [pæd] are both realized with a tap [ɾ] when the –ing suffix is attached, [pæɾɪŋ]. We show that despite greater distributional and acoustic support for the [t]-tap alternation, 12-month-olds successfully relate taps to stems with a perceptually-similar final [d], not the dissimilar final-[t]. Thus, distributional learning of phonological alternations is constrained by infants' preference for the alternation of (...) perceptually-similar segments. Further, the ability to relate variant surface forms emerges between 8- and 12-months. Our findings of biased learning provide further empirical support for a role for perceptual similarity in the acquisition of linguistically-relevant categories. We discuss the implications of our findings for phonological theory, language acquisition and models of the mental lexicon. (shrink)

Many functional glycoproteins are expressed on the lymphocyte cell surface. Some of them carry O-linked oligosaccharides (O-glycans), which are conjugated through serine or threonine residues. During various biological processes, including T-cell activation, a tetrasaccharide on the T-cell surface is dramatically converted to a branched hexasaccharide, called core2 O-glycan. The same structural change in O-glycans is also found on the lymphocytes from patients with immunodeficiency conditions such as Wiskott-Aldrich syndrome and AIDS. Several studies revealing the roles of core2 O-glycans (...) in immune responses show that this is a biologically significant change. In particular, core2 O-glycans expressed on the cell surface reduce cell–cell interactions, thereby regulating immune responses. Furthermore, core2 O-glycan is a key backbone structure in forming selectin ligands. Thus, O-linked oligosaccharides, in particular those containing core2 branches, play vital roles in immune responses and may play dual roles in certain situations. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes. BioEssays 23:46–53, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Standard linguistic analysis of syntax uses the T-model. This model requires the ordering: D-structure > S-structure > LF, where D-structure is the sentences deep structure, S-structure is its surface structure, and LF is its logical form. Between each of these representations there is movement which alters the order of the constituent words; movement is achieved using the principles and parameters of syntactic theory. Psychological analysis of sentence production is usually either serial or connectionist. Psychological serial models do not accommodate (...) the T-model immediately so that here a new model called the P-model is introduced. The P-model is different from previous linguistic and psychological models. Here it is argued that the LF representation should be replaced by a variant of Frege'sA three qualities (sense, reference, and force), called the FregeA representation or F-representation. In the F-representation the order of elements is not necessarily the same as that in LF and it is suggested that the correct ordering is: F-representation > D-structure > S-structure. This ordering appears to lead to a more natural view of sentence production and processing. Within this framework movement originates as the outcome of emphasis applied to the sentence. The requirement that the F-representation precedes the D-structure needs a picture of the particular principles and parameters which pertain to movement of words between representations. In general this would imply that there is a preferred or optimal ordering of the symbolic string in the F-representation. The standard ordering is retained because the general way of producing such an optimal ordering is unclear. In this case it is possible to produce an analysis of movement between LF and D-structure similar to the usual analysis of movement between S-structure and LF. The necessity of analyzing corrupted data suggests that a maximal amount of information about a language's grammar and lexicon is stored. (shrink)

Since last year, major initiatives have been undertaken by the chair of theoretical philosophy at the University of Tübingen in order to enhance the reception of analytic metaphysics in the European landscape. Here we review the 2013 summer workshop, intended to be the first of an annual series, on “Existence, Truth and Fundamentality”, the invited speakers being Graham Priest (Melbourne), Stephan Leuenberger (Glasgow), Dan López de Sa (Barcelona), Francesco Berto (Aberdeen), Friederike Moltmann (Paris – Pantheon Sorbonne) and Jason Turner (Leeds). (...) The workshop’s scope is fairly large, focusing on three different aspects of contemporary research in metaphysics. However, the underlying idea of organizers Thomas Sattig and Alessandro Torza consisted in exploring their interconnections and even new areas which possibly share the same problem spectrum. Also, they thought of bringing together both young and senior protagonists of the contemporary debate. In this sense, the main thread followed by the speakers consisted in enquiring the ideas of fundamentality, dependence and grounding with respect to ontology (Berto, López de Sa, Turner) and the truthmaking debate (Priest, Moltmann, Leuenberger), thus pretty much in line with some latest tendencies in metaphysics, such as, prima inter paria, the works of Kit Fine. When we say that something is more fundamental than something else, we move into a non-conventional (for the standards of 20 th century philosophy) metodological framework, hardly focusing on the question about what there is, and rather tackling the issue of how fundamentally there is what there is, or how the existence of something is required as a ground for the existence of other things. Here is how Jonathan Schaffer explains the methodological transition in his influential “On What Grounds What” (2009): -/- Among the many assumptions Quine and Carnap share is that metaphysical questions are existence questions, such as whether numbers exist. They only disagree on the further issue of whether such questions are meaningful (at least as the metaphysician might pose them). But why think that metaphysical questions are existence question of this sort? Return to Aristotle’s Metaphysics. There are virtually no existence question posed. The whole discussion is about substances (fundamental units of being). At one point Aristotle pauses to ask if numbers exist, and his answer is a brief and dismissive yes. [. . . ] For Aristotle, the question about numbers is whether they are transcendent substances or grounded in concreta. The question is not whether numbers exist, but how. (Schaffer, 2009, p. 347) -/- The conference opened with Graham Priest’s intriguing and peculiar review of Buddhist cornerstone “The Fundamental Verses of the Middle Way” (Mūlamadhyakamakārikā) by Nāgārjuna (ca. 150-ca. 250 AD), seen as a unrecognized forerunner of multi-valued semantics and dialetheism. Priest shows that Nagarjuna’s thought indeed has valuable analytic grip (contrary to the traditional mystical dismiss of his works altogether) and is even in accord to some formal schemas rejecting both the laws of excluded middle and non-contradiction. Dan López de Sa was interested in the topic of grounding, raising concerns about how to explain the kind of “reality” exemplified by what is not fundamental, but rather derivative on something else. He proposes a conceptual and non-primitive analysis of grounding as linked to fundamentality and derivation, and argues that the view can be advocated along with the acceptance that at least something is not fundamental. Subsequently, he illustrates an impressive range of applications linked to contemporary debates in meta-ontology, truthmaking and philosophy of time. Stephan Leuenberger discussed a semantics for “total logic”, a variant of first order logic which is claimed to have several applications with respect to the issue of excluding negative existentials from the scope of theories accounting for a given ’totality’ of facts. For example, materialism is the claim that everything there is can be traced back to physical facts or to truth implied by those facts. What about the claim that “There are no angels”? According to Leuenberger, ordinary logic falls prey of modal arguments (if it is possible that there are angels, by modus tollens, that it is not metaphysically necessary that everything there is is physical). So, there is space for the introduction of a new operator, the totality operator, claiming of what enters its scope that “that’s the whole truth”. Consequently, total logic’s semantics tackles David Chalmers’ well-known conceivability-based argument in favour of zombie’s (subjects producing behaviour but experiencing no qualia) possible existence. Friederike Moltmann presented a massive array of natural language-based examples on the role played by case-constructions, such as “it is the case that Caesar crossed the Rubicon”, “the case of the stolen statue”, “the case in which it might rain”, and so forth. She suggests that we should take surface phenomena of our language very seriously with regard to the determination of ontological categories and truth-makers. Cases are provided by many natural languages with their own existence predicates (“to occur” and “to present itself ”), and these do not apply to other kind of entities, such as objects and events. Trying to derive a substantive thesis on their nature, she claims that they are filtered entities, a structure taking into account some features of the corresponding objects and events and preserving their relational pattern. Jason Turner discussed meta-ontological concerns against the claim that ontological debates are defective. Analysed the structure of a metaphysical theory and identified two different forms of defectiveness that can occur in ontological questions, the defection from without and the defection from within, the author provided an original solution in order to avoid such difficulties. He argued thus in favor of a logical constancy, a translation principle thanks to it would be possible reconceive an ontological defection. Lastly, Francesco Berto’s talk closed the workshop with a sagacious discussion of meinongian quantification. He substains that Meinongians and Quineans experience no conceptual equivocation. Even if the former claims that “There are things that do not exist”, something that the latter contrasts with the interpretation of existential quantifiers as all-including, they still rely upon the same concept of “existence” and they understand each other when they are outside the ontology room, so that it cannot be that they lack competence. Subsequently, Berto deals with the objection that Meinongians commit analytic falsehood in separating the meaning of “to be” from that of “exists”. The Quinean has no independent evidence for analytic equivalence aside from her emphatic stress on the “is” in “there is”. Meinongians, however, can retort to linguistic considerations and claim that existence predicates display fairly different functions. -/- As for what regards our internal division of the “philosophical labor”, Fabio Ceravolo reviewed Moltmann and Berto’s talks; whereas Mattia Cozzi took care of Priest’s and Leuenberger’s, and Mattia Sorgon of those given by López de Sa and Turner. Conclusively, we would like to thank Thomas Sattig and Alessandro Torza for all of their organizational efforts and the kind welcome they reserved to us. We hope we will have further opportunities to collaborate with Tübingen in supporting similarly innovative and valiant european initiatives. (shrink)

Building on Crane’s intentionalism, the paper proposes a variant of response-dependentist view of colors. To be of a color C is to have a disposition to cause in normal observers a response, namely, intentional phenomenal C-experience. The view is dubbed “response-intentionalism”. It follows from the following considerations, with the red of a tomato surface taken as an example of color C. Full phenomenal red is being visaged as being on the surface of the tomato. Science tells us (...) that full phenomenal red is not on the surface of the tomato. Equally, full phenomenal red is not a property of subjective state but its intentional object. Response-intentionalism follows by considerations of charity, i.e. minimizing and rationalizing the error of the cognizer, and of inference to the best explanation: being red in scientific sense is being such as to cause the response visaging phenomenal red in normal observers under normal circumstances. (shrink)

During mouse early development cell adhesion molecules are indispensable for the embryo organisation. A family of molecules probably involved in development is the transmembrane glycoprotein CD44 family, which exists in multiple isoforms. These are generated by alternative splicing of the pre‐mRNA, resulting in the enlargement of the extracellular part of the molecule. The standard form of CD44 is widely expressed in adult tissues and in embryos from day 9.5 post coitum onwards, while the numerous variant isoforms exhibit highly (...) specialised patterns of expression that are already in the egg cylinder at day 6.5 of development. In lymphohemopoiesis, specific variant isoforms also emerge at decisive differentiation stages. Although specific ligands for the variant region still await isolation, the highly organised expression of CD44 variant isoforms suggests they have a pivotal role in cellular interactions during early development, pattern formation and hemopoiesis. (shrink)

Neutrophil transepithelial migration is a central component of many inflammatory diseases of the gastrointestinal, respiratory and urinary tracts, and correlates with disease symptoms. In vitro modeling with polarized intestinal epithelial monolayers has shown that neutrophil transepithelial migration can influence crucial epithelial functions, ranging from barrier maintenance to electrolyte secretion. Studies have also demonstrated a dynamic involvement of the epithelium in modulating neutrophil transepithelial migration. Characterization of the molecular interactions between neutrophils and epithelial cells has revealed that transepithelial migration is dependent (...) on the neutrophil β2 integrin CD11b/CD18, and does not appear to involve adhesive interactions with the selectins or intercellular adhesion molecule‐1. Recent studies have implicated another transmembrane glycoprotein, CD47, as a crucial component of the transepithelial migration response. While the precise function of CD47 is not known, current evidence suggests that CD47‐dependent events occur after CD11b/CD18‐mediated neutrophil adhesion to the epithelium. This review will highlight key features of the current understanding of the molecular events important in neutrophil migration across epithelial surfaces. (shrink)

The term etonism is from «Etona» that means flag, marks, evidence, and reason in Kikôngo. The variants in Umbûndu: etonolo or etonuilo means, allegations, reasons, indulgence (tolerance). The Nyaneka form is etŏnya: 1) reasons, 2) allegations, 3) indulgence and 5) the justice and the tolerance. Etona is Angolan artist (sculptor/painter). In his sculpture they are morphologically evidenced three treatments in the surface of the matter, namely 1) flat treatment; 2) rude treatment and finally 3) accidental treatment. Each one is (...) a code: #1. The flat treatment indicates well-knowledge; a man of superior class; race or tribe or religion of majority; thought well-organized and structured. In painting, the hot intensity indicates dominance, prosperity, energy, intense desires; #2. The rude treatment reveals an acquired knowledge without academism, self-taught; medium class men; speech out of the scientific perimeters but with certain admissibility; race, tribe or religion of lot of people, but not of majority. In his painting, the neutral intensity marks the balance and inspires recomfort nurtured from two opposed poles (hot and cold); #3. The accidental part of the sculpture indicates some knowledge’s lack (pure empiricism); inferior class; race, tribe, religion of minority. In the painting, the cold intensity is naturally contrary of #1. Etonism is the tolerant reason between #1=I, #2=YOU and #3=HE. All of them form the coherent society that we call WE: the Etonian jusphilosophy that African peoples need for stability of their democracies and finishing their War. (shrink)

In today’s America the persistence of crushing poverty in the midst of staggering affluence no longer incites the righteous jeremiads it once did. Resigned acceptance of this paradox is fueled by a sense that poverty lies beyond the moral and technical scope of government remediation. The failure of experts to reach agreement on the causes of poverty merely exacerbates our despair. Are the causes internal to the poor – reflecting their more or less voluntary choices? Or do they emanate from (...) structures beyond their control? If both of these explanations are true, poverty experts will need to shift their focus to a hitherto under-theorized concept: coercion. I defend this claim by appealing to distinct areas of philosophical inquiry: social epistemology and moral theory. Poverty knowledge is directly related to both of these inquiries. The aim of poverty knowledge is clearly moral: to reduce suffering and to empower the weak. While the former aim is grounded in utilitarian thinking, the latter aim is grounded in the social contractarian insight that poverty is unjustly coercive, imposing excessive limits on the opportunities and choices of the poor that render them vulnerable to domination by others. Equally obvious is the social nature of poverty knowledge. All knowledge depends on the reliable testimony of others. Poverty knowledge not only ostensibly offers us the most reliable, scientific beliefs about the causes and effects of poverty, thereby determining how we morally judge the poor and their poverty, but it reciprocally bases its understanding of poverty on what the poor themselves have to say about it. What unites both social epistemology and moral theory – at least the social contract variants I will be examining here – is concern about the limits and possibilities of rational choice. As poverty knowledge came of age in the fifties and sixties, it absorbed the language of rational choice prevalent in economics, especially the Keynesian economics whose moral underpinnings can be found in Rawlsian social contract theory. Echoing a different economic theory supported by a different, more libertarian, brand of social contract theory, poverty expertise in the eighties continued to use an abstract model of rational choice. I submit that, in both early and later epochs of poverty expertise, reliance on rational choice reasoning prevented poverty experts from appreciating the coercive impact of poverty on the poor. Social epistemology explains this failure by demonstrating the poverty of rational choice thinking and its mistaken reliance on inflated commonsense expectations about the capacity of individuals to calculate their long-term interests, free from the distortions of social bias. Social epistemology not only exhibits the dangers of not relying on expert testimony, but it also exhibits the dangers of relying on an unreliable source of expert testimony that has removed itself from its human subject matter. In order for poverty experts to become more reliable educators about poverty’s coercive impact on the poor they must return to their discipline’s social epistemological roots. Only a more descriptive and explanatory sociology can narrate a comprehensive story about how the lived experience of poverty relates to the larger social system. The social contractarian model best suited to underwriting this kind of poverty knowledge, I submit, is the discourse theoretic model that has been championed by Jürgen Habermas. When applied as a pedagogical method of dialog and not as a social contractarian model of rational normative consent, discourse theory highlights the unique epistemological advantages of empathetic understanding that are so essential to dispelling stereotypes about the poor. Dispelling these stereotypes is the first step toward respecting the poor as free agents who are nonetheless forced to make suboptimal choices. My defense of these claims proceeds as follows: Part One argues that poverty expertise rightly deserves the opprobrium critics have heaped on it. The charge – leveled by progressives and conservatives alike - that such expertise is ideological is true to the extent that poverty knowledge has all-too-easily accommodated the political aims of the agency that has funded it: the federal government. The shift from the war on poverty to the war on the poor – and the resulting shift from blaming poverty on economic structures to blaming it on the culture of poverty – would not have been possible without an increased emphasis on data gathering aimed at measuring poverty rather than describing it. Part Two assesses the consequences of turning away from qualitative research to statistical analysis: the coercive nature of poverty becomes invisible beneath the surface of aggregate individual choices. The failure to grasp how voluntary choices, ostensibly based on rational, self-interested calculations, can be coerced by social structures - and thereby lead to sub-optimizing behavior – invites the conclusion that the poor have only themselves to blame for their misery. Part Three suggests that this pathologization of the poor directly controverts the major aim of poverty research: to empower the poor as free and equal parties to the social contract. I argue that the different varieties of social contract theory that have justified poverty expertise over the last forty years – the welfarist model pioneered by Rawls and the market-based model defended by Nozick – embrace the same rational choice models favored by poverty experts and so conspire with the latter in neglecting important dimensions of poverty-related coercion. While the welfarist model conceals the coercive nature of bureaucratically administered entitlement programs and top-down urban renewal policies, the market-based model conceals the coercive nature of economic class structures. The discourse-theoretic alternative proposed by Habermas endorses a populist, democratic response to the overly abstract rational choice assumptions embedded in these other models. Despite this advance over its counterparts, the chief advantage of discourse theory for poverty knowledge, I submit, resides less in its proposed procedure of rational collective choice than in its heuristic as a dialogical method of social learning. I demonstrate this claim in Part Four, where I turn to the social epistemological insights of Allen Buchanan. Social epistemology offers a much needed corrective to theories of knowledge that rely on the reasoning capacities of isolated individuals. By stressing the connection between moral response and social belief, on one hand, and the dependence of social belief on epistemic authorities, on the other, social epistemologists suggest ways in which we can learn to distinguish reliable from unreliable authorities and become aware of our own error-prone cognitive proclivities. Their insights need to be supplemented by moral epistemologists who stress the affective dimension of knowledge, above all, the role that empathy plays in understanding the plight of others. Drawing from victim narratives, Diana Meyers shows that switching between first-person experiences of one's own and third-person reconstructions of others' experiences is essential to appreciating the gravity of human rights violations and the seriousness of human rights claims. It goes without saying that such empathy is just as essential to understanding the plight of the poor. Meyers mainly has in mind empathetic understanding that has been facilitated by third-person observation and literary encounter, but the importance of visceral and corporeal representation suggests that face-to-face dialog may sometimes be a more effective way to facilitate empathetic understanding. (shrink)

The human blood coagulation system comprises a series of linked glycoproteins that upon activation induce the generation of downstream enzymes ultimately forming fibrin. This process is primarily important to arrest bleeding (hemostasis). Hemostasis is a typical example of a molecular machine, where the assembly of substrates, enzymes, protein cofactors and calcium ions on a phospholipid surface markedly accelerates the rate of coagulation. Excess, pathological, coagulation activity occurs in “thrombosis”, the formation of an intravascular clot, which in the most dramatic (...) form precipitates in the microvasculature as disseminated intravascular coagulation. Thrombosis occurs according to a biochemical machine model in the case of atherothrombosis on a ruptured atherosclerotic plaque, but may develop at a slower rate in venous thrombosis, illustrating that the coagulation machinery can act at different velocities. The separate coagulation enzymes are also important in other biological processes, including inflammation for which the rapid conversion of one coagulation factor by the other is not a prerequisite. The latter role of coagulation enzymes may be related to the old and probably maintained function of the coagulation machine in innate immunity. BioEssays 25:1220–1228, 2003. © 2003 Wiley Perioicals, Inc. (shrink)

During mammalian fertilization sperm bind to the egg's zona pellucida (ZP) after undergoing capacitation. Capacitated mouse sperm bind to mZP3 (one of three ZP glycoproteins), undergo the acrosome reaction, penetrate the ZP, and fuse with egg plasma membrane. Sperm protein 56 (sp56), a member of the C3/C4 superfamily of binding proteins, was identified nearly 20 years ago as a binding partner for mZP3 by photoaffinity cross‐linking of acrosome‐intact sperm. However, subsequent research revealed that sp56 is a component of the sperm's (...) acrosomal matrix and, for sperm with an intact acrosome, should be unavailable for binding to mZP3. Recently, this dilemma was resolved when it was recognized that some acrosomal matrix (AM) proteins, including sp56, are released to the sperm surface during capacitation. This may explain why uncapacitated mammalian sperm are unable to bind to the unfertilized egg ZP. (shrink)

An important aspect of the developmental maturation of lymphocytes is their capacity to locate and enter lymphoid organs with great rapidity and specificity and to follow certain routes within these organs for the attainment of particular immunological capabilities. It is now known that this “homing response” to lymphoid organs involves specific glycoprotein receptors on the lymphocyte cell surface. The biochemistry of these receptors and their significance in normal and pathological immune responses are discussed.

N- and O-linked glycan structures of cell surface and secreted glycoproteins serve a variety of functions related to cell–cell communication in systems affecting development and disease. The more sophisticated N-glycan biosynthesis pathway of metazoans diverges from that of yeast with the appearance of the medial-Golgi β-N-acetylglucosaminyltransferases (GlcNAc-Ts). Tissue-specific regulation of medial- and trans-Golgi glycosyltransferases contribute structural diversity to glycoproteins in metazoans, and this can affect their molecular properties including localization, half-life, and biological activity. Null mutations in glycosyltransferase genes positioned (...) later in the biosynthetic pathway disrupt expression of smaller subsets of glycan structures and are progressively milder in phenotype. In this review, we examine data on targeted mutations affecting glycosylation in mice and congenital mutations in man, with a view to understanding the molecular functions of glycan structures as modulators of glycoprotein activity. Finally, pathology associated with the expression of GlcNAc-Ts in cancer and diabetes-induced cardiac hypertrophy suggest that inhibitors of these enzymes may have therapeutic value. BioEssays 21:412–421, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Over the last several years, a number of philosophers have advanced formal versions of certain traditional arguments for the incompatibility of human freedom with causal determinism and for the incompatibility of human freedom with infallible divine foreknowledge. Common to all of these is some form of a principle governing the transfer of a species of alethic necessity (TPN). More recently, a few clear and compelling counterexamples to TNP (and a variant of it) have begun to surface in the (...) literature. These attacks on TNP are developed along somewhat different lines (and were apparently worked out independently of each other). I will show that despite the differences in presentation, however, all of the compelling counterexamples that have been offered turn on a common (and overlooked) basic feature. Once this feature is recognized, I suggest, one is naturally led to restrict the principle in a way that renders it immune to these counterexamples. (I further argue that the restriction I suggest has independent justification.) I then go on to consider two further attempts to show the invalidity of TNP for power necessity, ones that would not be forestalled by my restriction on TNP, and I argue that they are unsuccessful. In a final section, I compare my modified version of TNP for power necessity with a principle suggested in Ginet (1990). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.1 (2002) 55-59 [Access article in PDF] One Stage Is Not Enough Andrew W. Young and Karel W. de Pauw Keywords: delusions, Cotard delusion, Capgras delusion, cognitive neuropsychiatry. WE WELCOME THE OPPORTUNITY to offer our reflections on Philip Gerrans' interesting paper. Our opinion is that on fundamental issues we agree quite a bit—but there are clear differences when it comes to details.The most basic issue (...) concerns the nature of the enterprise. Like Gerrans, we think that it is possible to create testable accounts of the formation and maintenance of what would otherwise seem bizarre and inexplicable delusions, and that these accounts should be grounded in theoretical models of factors that underpin our everyday perception and reasoning. This general approach certainly forms part of what has been called cognitive neuropsychiatry. However, we disagree with Gerrans in that we see cognitive neuropsychiatry as an attempt to draw on the underlying logic of cognitive neuropsychology, rather than (as Gerrans implies) its current methods. The underlying logic of cognitive neuropsychological approaches has been to try to understand the effects of brain injury in terms of disruption of different components of theoretical models of normal abilities. In this approach, a model of normal performance is tested by its ability to account for the effects of brain injury. Where the model of normal performance also provides a convincing account of brain injury it is retained, and when it fails to account for effects of brain injury, it is revised or abandoned. In cognitive neuropsychiatry, the key theoretical move has been to argue that an adequate model of normal performance should be able to account for any disordered pattern (Ellis and Young 1990). The same logic of seeking to explain disordered performance by reference to models of normal function is then attempted, but for disorders that would usually fall within the province of psychiatry.In our opinion, however, cognitive neuropsychiatry will not simply involve importing the methods of cognitive neuropsychology into the new domain; they will need to be developed and adapted to fit the new agenda (Young 2000).In cognitive neuropsychology, progress has often come from the careful investigation of people with stable, selective deficits of fundamental cognitive functions involved in sensory analysis, memory, and verbal or motor output. In contrast, delusional beliefs can be relatively unstable; often they are only held for a few weeks or even days. When the delusions change, patients may modify or abandon them as suddenly as they seemed to form them, or they may give them up much more slowly and reluctantly. At the very least, this creates difficulties in the timing of investigations and in interpreting the relation of deficits and symptoms, which may be recorded on separate dates. These methodological problems [End Page 55] are exacerbated by the fact that deficits linked to complex abnormal experiences such as delusions may be multifaceted and diffuse, even when the delusions themselves have a specific content or theme. Such complications do not invalidate cognitive neuropsychiatry, but they do mean it will need to develop its own methods for dealing with them and making appropriate inferences.One of the key complexities that has surfaced already involves the idea that delusional beliefs might reflect the interaction of two or more contributory factors. Gerrans discusses a particular variant of this idea, which had been suggested by Young and Leafhead (1996) as an approach to understanding the Cotard delusion: The Cotard delusion represents a depressed person's attempt to account for abnormal perceptual experiences. It follows that the delusion is based on an unfortunate interaction between different contributory factors. One set of factors creates the abnormal perceptual experiences, which are characterised by lack of emotional responses and feelings of emptiness, depersonalisation and derealisation. The other factors result in a misinterpretation of these perceptual changes, in which the patients' depressed moods lead them correctly to attribute the changes to themselves, but to exaggerate their consequences. (Young and Leafhead, 1996, 166) Gerrans describes this as a two-stage account, but argues that a one-stage account based only on abnormal perceptual... (shrink)

Word co‐occurrence patterns in language corpora contain a surprising amount of conceptual knowledge. Large language models (LLMs), trained to predict words in context, leverage these patterns to achieve impressive performance on diverse semantic tasks requiring world knowledge. An important but understudied question about LLMs’ semantic abilities is whether they acquire generalized knowledge of common events. Here, we test whether five pretrained LLMs (from 2018's BERT to 2023's MPT) assign a higher likelihood to plausible descriptions of agent−patient interactions than to minimally (...) different implausible versions of the same event. Using three curated sets of minimal sentence pairs (total n = 1215), we found that pretrained LLMs possess substantial event knowledge, outperforming other distributional language models. In particular, they almost always assign a higher likelihood to possible versus impossible events (The teacher bought the laptop vs. The laptop bought the teacher). However, LLMs show less consistent preferences for likely versus unlikely events (The nanny tutored the boy vs. The boy tutored the nanny). In follow‐up analyses, we show that (i) LLM scores are driven by both plausibility and surface‐level sentence features, (ii) LLM scores generalize well across syntactic variants (active vs. passive constructions) but less well across semantic variants (synonymous sentences), (iii) some LLM errors mirror human judgment ambiguity, and (iv) sentence plausibility serves as an organizing dimension in internal LLM representations. Overall, our results show that important aspects of event knowledge naturally emerge from distributional linguistic patterns, but also highlight a gap between representations of possible/impossible and likely/unlikely events. (shrink)

In three studies, we explored the retention and transfer of tool-making knowledge, learnt from an adult demonstration, to other temporal and task contexts. All studies used a variation of a task in which children had to make a hook tool to retrieve a bucket from a tall transparent tube. Children who failed to innovate the hook tool independently saw a demonstration. In Study 1, we tested children aged 4 to 6 years (N = 53) who had seen the original demonstration (...) 3 months earlier. Performance was excellent at the second time, indicating that children’s knowledge was retained over the 3 month period. In Studies 2 and 3 we explored transfer of the new knowledge to other tasks. In Study 2, children were given two variants of the apparatus that differed in surface characteristics (e.g. shape and colour). Participants generalised their knowledge to these new apparatuses even though the new pipecleaner also differed in size and colour. Five- to 6-year-olds (n = 22) almost always transferred their knowledge to problems where the same tool had to be made. Younger, 3- to 5-year-olds’ (n = 46), performance was more variable. In Study 3, 4- to 7-year-olds (N = 146) saw a demonstration of hook making with a pipecleaner, but then had to make a tool by combining pieces of wooden dowel (or vice versa: original training on dowel, transfer to pipecleaner). Children did not transfer their tool-making knowledge to the new material. Children retained tool-making knowledge over time and transferred their knowledge to new situations in which they needed to make a similar tool from similar materials, but not different materials. We concluded that children’s ability to use tool-making knowledge in novel situations is likely to depend on memory and analogical reasoning, with the latter continuing to develop during middle childhood. (shrink)

Until relatively recently, researchers believed that synaesthetic sensations and their triggers were arbitrarily paired, and entirely idiosyncratic from one synaesthete to the next. Put differently, they believed that no two synaesthetes would have similar experiences from the same set of triggers, unless this had occurred by chance. This position likely arose because, prior to the internet, it was extremely difficult to recruit more than a small handful of synaesthete participants, and on the surface, synaesthetes do tend to disagree on (...) their associations when compared one-on-one. However, recent advances in communication have allowed researchers access to far larger groups of synaesthete participants, and this has changed our opinion about how similar synaesthetes might in fact be. A dedicated body of research has now shown that synaesthetic associations are built, to some extent, on a set of unconscious 'rules', shared across synaesthetes. These rules dictate the choice of sensation for certain triggers, and allow us to see patterns emerging which, although not absolute, provide a type of coherence across synaesthetes as a whole. I shall also show that some of these underlying rules operate in the population at large, to allow all individuals to make intuitive pairings across the senses. This chapter describes some of these rules, across a range of different modalities, and across different variants of synaesthesia. (shrink)

The paper pinpoints certain unrecognized difficulties that surface for recombination and duplication in modal realism when we ask whether the following inter-world fixity claims hold true: 1) A property is perfectly natural in a world iff it is perfectly natural in every world where it is instantiated; 2) Something is mereologically atomic in a world iff all of its duplicates in every world are atomic. In connection to 1), the hypothesis of idlers prompts four variants of Lewis’s doctrine of (...) perfectly natural properties, all deemed unsatisfactory for the purposes of duplication and recombination. By means of 2), instead, we show that the principle of recombination does not countenance the atomicity or non-atomicity of duplicates; but it should, because it is genuinely possible that: a) something, which is atomic, is non-atomic; and b) something, which is non-atomic, is atomic. In discussing 1) and 2), the paper substantiates a tension in Lewis’s metaphysics between modal intuitions and the reliance on the natural sciences. (shrink)

With his recent introduction of `posthumanism, " a decentered variant of constructivist sociology of science, Andrew Pickering advertises novel conceptual resources for social theorists. In fact, he tenders nothing less than a fundamental reordering of social thought. By invoking the concept of "material agency, " Pickering seeks to redefine the relationship between "Nature" and "Society," while dismissing the "humanist bias" inherent in sociological inquiry. However, for all its ambition and good intentions, posthumanism delivers only analytical inconsistencies, the consequences of (...) an uneasy synthesis of pragmatist and poststructuralist influences. When translated into the language of conventional sociological theory, these problems surface as an inadequate treatment of human agency. The works of the original pragmatists, particularly C.S. Peirce and G.H. Mead, illustrate how the objectives of posthumanism can be achieved without decentering, suggesting a renewed appreciation of "humanist" sociologies. (shrink)

A large proportion of tumour‐associated antigens seem to be determined by carbohydrate structures. Advances in the study of the antigenicity of cell‐surface carbohydrates have been hampered by the absence of advanced monoclonal hybridoma technology comparable to that available for the study of protein antigens. Monoclonal antibodies have been raised against a carbohydrate epitope (43–9F) that is associated with the proliferative features of squamous lung carcinomas. These were used in turn to generate anti‐idiotype antibodies with homology to 43–9F. The method (...) and its possible applications are described, together with a procedure to detect rare cell membrane variants within large populations. (shrink)

We analyze model-theoretic connected components in extensions of a given group by abelian groups which are defined by means of 2-cocycles with finite image. We characterize, in terms of these 2-cocycles, when the smallest type-definable subgroup of the corresponding extension differs from the smallest invariant subgroup. In some situations, we also describe the quotient of these two connected components. Using our general results about extensions of groups together with Matsumoto–Moore theory or various quasi-characters considered in bounded cohomology, we obtain new (...) classes of examples of groups whose smallest type-definable subgroup of bounded index differs from the smallest invariant subgroup of bounded index. This includes the first known example of a group with this property found by Conversano and Pillay, namely the universal cover of [Formula: see text], as well as various examples of different nature, e.g. some central extensions of free groups or of fundamental groups of closed orientable surfaces. As a corollary, we get that both non-abelian free groups and fundamental groups of closed orientable surfaces of genus [Formula: see text], expanded by predicates for all subsets, have this property, too. We also obtain a variant of the example of Conversano and Pillay for [Formula: see text] instead of [Formula: see text], which was not accessible by the previously known methods. (shrink)

In this article I analyse the hidden genealogical link between portrait photography, used for criminological and psychiatric purposes, and contemporary systems of biometric identification of the human face. The aim is to highlight the shift between the emphasis on the importance of the human ‘expert eye’ in recognizing the face when talking about nineteenth-century photography and the use of computer technology that produces and reads digital facial images. In both cases, however, these are modes and variants of reducing and flattening (...) the human face; the face itself disappears under the onslaught of technologies of vision and mediation, becoming a mere data set. Special attention is devoted to the pose, the frontal view, which is the technological a priori of the empirical possibility of recognition, articulated through the history of visualization of the face from early portrait photography to facial recognition systems. Consequently, what we call the ‘face’ is a simulacra of individual the face presented to the apparatus: the ‘real’ face is transposed upon multiple technological layers (camera – plates – photographic surface), losing its characteristic features to be re-written according to specific techniques of measurement. (shrink)

Summary Amodal completion involves the impression of existence and properties of visually occluded parts of objects. One aspect of this phenomenon that has been somewhat neglected is the amodal completion of color, which involves the impression that amodally completed surfaces have a particular color. In this paper, this aspect is investigated by constructing a large number of displays with identical target figures embedded in systematically varying contexts, to find out which contexts are conducive for amodal completion of color and which (...) are not. In this setup, the main effects of changes of contexts are changes of geometric and photometric features of junctions along the borders of the target regions, which can cause dramatic differences in the appearance of those regions. Generally, a certain arrangement of T-junctions supports the impression of amodal completion of color, and it can be argued that certain types of X-junctions support a variant of this effect as well. (shrink)

Yvon Garlan En visitant et revisitant les ateliers amphoriques de Thasos p. 269-329 L'article fait le bilan des recherches sur les ateliers amphoriques de Thasos entreprises en 1977 et présente, sous forme de tableaux commentés et abondamment illustrés, les milliers de timbres qui en sont issus. Les dernières fouilles réalisées au Molos par le service archéologique ont fourni un matériel particulièrement abondant (plus de 3 000 exemplaires) et riche en indications sur les variantes de matrices et l'impression des cachets entre (...) le dernier tiers du IVe siècle et le début de la seconde moitié du IIIe siècle. Le dépotoir de Chioni, fouillé en 1995 par l'École française d'Athènes, se scinde en deux ensembles : le premier contenant une cinquantaine de timbres «anciens » du milieu du IVe siècle et le second plus de 400 timbres «récents » qui mentionnent 85 éponymes postérieurs aux environs de 320. Chaque année, de 1978 à 2003, les sites connus ou présumés de production amphorique ont été l'objet de collectes de surface qui ont permis d'esquisser ou de compléter leur étude. La classification chronologique des magistrats amphoriques de Thasos a été revue en conséquence, sous forme d'un tableau argumenté, du début du timbrage «récent » (qui devrait se dater des environs de 333 av. J.-C.) jusque vers 210 (plusieurs décennies sans doute avant sa disparition). (shrink)

According to John Mackie, moral talk is representational but its metaphysical presuppositions are wildly implausible. This is the basis of Mackie's now famous error theory: that moral judgments are cognitively meaningful but systematically false. Of course, Mackie went on to recommend various substantive moral judgments, and, in the light of his error theory, that has seemed odd to a lot of folk. Richard Joyce has argued that Mackie's approach can be vindicated by a fictionalist account of moral discourse. And Mark (...) Kalderon has argued that moral fictionalism is attractive quite independently of Mackie's error-theory. Kalderon argues that the Frege-Geach problem shows that we need moral propositions, but that a fictionalist can and should embrace propositional content together with a non-cognitivist account of acceptance of a moral proposition. Indeed, it is clear that any fictionalist is going to have to postulate more than one kind of acceptance attitude. We argue that this doubleapproach to acceptance generates a new problem -a descendent of Frege-Geach -which we call the acceptance-transfer problem. Although we develop the problem in the context of Kalderon's version of non-cognitivist fictionalism, we show that it is not the noncognitivist aspect of Kalderon's account that generates the problem. A closely related problem surfaces for the more typical variants of fictionalism according to which accepting a moral proposition is believing some closely related non-moral proposition. Fictionalists of both stripes thus have an attitude problem. (shrink)

My aim in this paper is to investigate the variants of directionality implied in visual hieratic texts as religious markers in the sacrosphere, which are substantially expressed in the form of a wayside shrine/cross. The methodological underpinnings for this project rely on the proposed semiotactics : the investigative perspective modeled after phonotactics – a branch of phonology investigating the restrictions on and the possibilities of phoneme combinations in languages. The study draws on digital documentation of wayside shrines, crosses, and sacrality (...) markers on houses collected by the author in various European countries, focusing in particular on the material collected in the area of present Slovakia, Ukraine, Austria, Slovenia, and the region of the Beskid Mountains in Poland. It shows how bodily hexis is inscribed into the phenomenology of a wayside shrine through particular types of hierophanic dynamics. The study also focuses on the aspect of headedness and markedness in the nano-structure of a sign, surfacing as directionality in the conceptualization of the religious sphere by particular communities. (shrink)

The following is excerpted from Sean Gurd’s translation of Euripides’ Hippolytus published with Uitgeverij this year. Though he was judged “most tragic” in the generation after his death, though more copies and fragments of his plays have survived than of any other tragedian, and though his Orestes became the most widely performed tragedy in Greco-Roman Antiquity, during his lifetime his success was only moderate, and to him his career may have felt more like a failure. He was regularly selected to (...) have his plays performed in the annual festival of Dionysus at Athens. But the plays were performed in a competition, and in the competitions he lost and lost, winning first place only five times in a career that spanned more than forty years. His corpus reads like the remains of a life spent trying to get a few things right and never being quite satisfied: scenes and schematized combinations of elements recur again and again, each time slightly changed. Hippolytus itself is an example: it contains two scenes in which a sick or dying character lies on a couch or a stretcher and is surrounded by silence and grief; he had experimented with such scenes in Alcestis, and would work with them again in Herakles and Orestes. Nor, judging from appearances, was he immune to the desire to score a hit, or to satisfy the audiences and the judges at the competition. Hippolytus is a rewrite of another Hippolytus, performed several years earlier, which scandalized the audience and certainly did not take first place. In that earlier Hippolytus (called by later writers Hippolytus Veiled), Euripides fashioned a Phaedra who was neither ashamed of loving her stepson nor incapable of taking steps to satisfy her desire. The forwardness of her approach to Hippolytus so outraged him that he covered his head with a robe (hence the play’s later title). Euripides liked to write energetic and self-confident women like this. He staged his Medea in 431, just three years before he revised Hippolytus, and in it the jilted title character murders her children in revenge for Jason’s new marriage to a more politically advantageous wife. Another flop: the play came in third of three. Evidently the judges did not like their women showing agency, especially when the consequences were transgressive. “The ornament of women,” wrote another great Athenian a little earlier, “is silence.”i Euripides’ Medea and his first Phaedra had other decorations. So three years after Medea crashed and burned and some time after the first Hippolytus suffered the same fate, he produced another Hippolytus play with a different setting and story. How could this one not have been a reaction to the failure of the first? “Second thoughts are always better,” he has one of his characters say, as though he were offering an apology for his first thoughts on the same story. In this new version, Phaedra is suicidally ashamed of her love, choosing to die rather than have it discovered, and willing to bring down her beloved Hippolytus in the service of the same end. Now it is Phaedra herself who covers her head in shock and horror at her desire. Only an intermediary, a slave of the house and an old crone with her fingers in all sorts of illicit pots, communicates Phaedra’s secret – against orders – and in consequence brings about the demise of two resolutely moral figures. It worked. For his tale of two well-born nobles with an unswerving commitment to moral action, destroyed by the meddling of a slave (and by the hostility of some particularly uncaring divinities), the judges crowned Euripides winner. It was the first time he had won, after almost thirty years of work. *** What Hippolytus wants more than anything else, as he protests with outrage just before leaving Trozen for the last time, is the benefit of due process – oaths, witnesses, an investigation that would reveal who really lusted after whom. Ironic, given that in the first Hippolytus, as far as we can make out, he did get a trial – but too late, and Theseus’ successful processing of Hippolytus failed to prevent his death. I cannot help hearing in the second Hippolytus’ complaints the anger of his authorial semblable who lost year after year by a process of judging that might have seemed brutal to him. Judges took no cognizance of how he worked, how long or hard or why; they just voted, and Euripides lost. But then I hear, in the fate of the first Hippolytus, an even grimmer commentary. Processed or not, we lose. We run aground. At the very least, this might cast a darker shadow on the business of watching or reading a play: in that twilight, things move too fast to make a fair assessment and, in any case, the reasonably high definition of what you see and hear belies the truth of indistinction, the multiplicities just below the surface. Watching is a constrained activity, a form of captivity, but reading is plastic. This translation was begun to supply the script for an audio version of the play, recorded in the spring of 2012, and here and there it sacrifices literalness for sayability and the voices and passions of the actors on that occasion. But it was finished to be read, and engineered to create a reading caught between the poles of specificity and non-specificity that the play itself conjures and relies on at its generative core. Thus two texts: the one clear, perhaps overprecise, respectably modern in its presentation, and the other ancient, a reasonable approximation of the classical reading process, and indistinct in vital ways. Like early modern dramatic texts, the exact provenance and original function of the scripts that have made it down to us are unknown. We do know that the ultimate survival of Hippolytus was thanks to its wide-spread use as a school text. But its relation to the first performance in 428 BCE is a matter only of speculation. Euripides presumably had a fair copy before production began; it was probably modified during rehearsals. The actors may have had copies, too (probably the young men who served in the chorus did not). The chor?gos, a wealthy Athenian who paid for the production, might have been presented with or just made sure to get his hands on a high-quality text, to commemorate the play’s success. Fans might have been able to buy copies. Any one of these sources might have provided the ultimate progenitor of our text. Several of them might have, in fact, if later editors compared and conflated traditions. The plays toured extensively in the Greek-speaking world, and were restaged as repertoire for centuries afterwards. In the process they were subjected to enough modifications by producers and actors that in the later fourth century the Athenian statesman Lycurgus had a law passed prohibiting performances at Athens from deviating from the official “city” text of the tragedies (which he had commissioned). It is unlikely that the city text was the last word; but it marks an important moment in Athens’ role in their dissemination, since after this the major sites of textual curatorship moved overseas, to Alexandria, Pergamum, Rome, Antioch, Constantinople. Any single text of any single play is thus no more than a moment of clarity and stability, crossed and subtended by multiple vectors of change, including that of textual flux (from Euripides’ first drafts to the latest printed text) and that of Euripides’ life work as a writer, in the light of which the Hippolytus is just one attempt to produce something exactly right, to win the prize or finally satisfy himself or prove to himself that all this longing for perfection was a waste of time. I am intrigued by the possibility that a single text might somehow serve as a lens onto this wider zone of indistinction, representing a small region clearly but nonetheless containing a blurred image of the whole, like a Leibnizian monad. After all, no text is a witness: it is, rather, a perception and a performance, and what every Hippolytus must perform is the awkward overlay of singular and plural, social practise and subliminal drive, that structures the tragedy. Modern critical editions can do this by juxtaposing a (relatively) clean and simple text with a textual apparatus reporting variants and theorizing the relationship between textual instantiations. A translation lacks the resolution to catch the fine variations which feed into the construction of an apparatus. But there are other means to hand. Guessing at the exact words of the original text is always just that – guessing – though Hippolytus is less problematic than plays like Iphigenia at Aulis. But we can make a pretty secure guess at what such a text looked like. Texts read by fifth-century readers were fundamentally different from what is presented in the best medieval MSS and printed in modern publications. The texts of Euripides’ time and for many centuries afterwards did not indicate word division with spaces (or by any other means) and were extremely sparing in punctuation, often avoiding it altogether. There was only one “case” of letters – what we call “capitals.” Musical sections were inscribed as though they were prose, without line endings to reflect their rhythm or their rhetorical structure. There was no indication of the speakers within a dramatic text, either. The earliest surviving dramatic texts, which come from over a century after Euripides’ death and a time which was much more elaborate and precise in its textual culture, indicated speaker-change with a little line or paragraphos below the line and a double-point [:] at its end. This convention almost certainly does not date back to Euripides’ own time; it may not even date to Lycurgus. In any case, such indications were understood to be readers’ marks: they did not have the same authority as the text and they were subject to readers’ revisions. At least ideationally, if not in concrete and distinguishable fact, a dramatic text was understood as containing no indication of speaker-change (and certainly none of who was saying what). The reader had to figure that out for him-/herself. The clear, legible, easy texts we are accustomed to reading are the fabrications of medieval and modern reading cultures. The first text, then, presents the translation as the text would have been in the mid-fourth century, perhaps decades after Euripides’ death. The second text processes Hippolytus, makes sense of it and makes it “readable.” That is: too distinct, dangerously so. It gets in your way, conjures fantoms, tries to make you see. Fragments of the Hippolytus Veiled, otherwise almost entirely lost, are juxtaposed with similar passages in the text – not to suggest a reconstruction, but a dialogue and a complex set of reassessments. I have not tried to represent the full variety of textual variants, but I have signalled where, for one reason or another, the text is soft and different editions propose excisions or changes. The two texts must be read together: you, reader, form the bridge between the distinctly seen and the indistinct invisible. You, in the end, will be its mask. *** illsandhateddiseaseswhatcanidoforyouwhatshouldinotdohereisthelightandthebrightairyoursickbedisnowout s idethehouseyoureverywordwastocomeherebutyouwillrushbacktoyourbedroomagainyoufadequicklyyoudelig htinnothingyoudislikewhatyouhaveyoulovewhatyoudontitsbettertobesickthantendthesickthefirstissimpleto the secondattachesheartspainandhandsworkeveryhumanlifeispainfulthereisnoendtotoildarknesshidesbehindclo udswhateverisdearerthanlifeweproveunhappyloversofwhatshineshereforlackofknowledgeofanotherlifethere isnoproofforthingsbeneaththeearthonlystoriessustainus liftmybodystraightenmyheadthebondsofmylimbsareloosenedtakemyhandsandmypalearmsthishatistooheavy formyheadtoweartakeitoffspreadmyhairovermyshoulders couragechilddonttossandturnsoviolentlyyouwillbearyoursicknessmoreeasilywithpeaceandanoblemindallmort alssuffer aiaiiwanttodrinkpurewaterfromadewyspringiwanttoliebackandrestunderthetreesinsomegrassymeadowchildw hycrydontsaythesethingsnearthecrowdhurlingwordsmountedonmadness sendmetothemountainiwillgototheforestwherebeastkillingdogspressthespotteddeergodsilongtoshouttothedo gstoshootthethessalianjavelinpastmyblondhairtoholdthebarbeddartinmyhandwhythisanxietychildwhatdoyouc areabouthuntingwhydoyoulustforflowingspringstheresahillwithwaterjustnexttothetowerwecangetyouadrinkt h ereartemismistressofthesaltlakeandthecoursethunderingwithhorseshoovesiwishiwereonyourplainsbreakings t uds whythrowthesefrenziedwordsaboutjustnowyouweresettingoutforthemountaintohuntandnowyoulongforhorses onthewavelesssand thesethingsneedanoracletotellwhichgodreinsyouinanddrivesyoufromyoursenseschild whathaveidonehowfarhaveibeendrivenfromgoodthoughtsiwascrazyiwascursedbysomepowerpheupheualasn ursecovermyheadagainimashamedofwhativesaidcovermeatearmovesdownfrommyeyeanditembarrassesm eithurtstostraightenourmindanditisterribletobeinsanebesttodiebeforeyoubecomelucidagain illcoveryoubutwhenwilldeathcovermeimoldivelearnedalotmortalsshoulddrinkoffriendshipmoderatelynotfrom th edeepestmarrowofthesoulamindslovecharmsshouldbeeasytoundoorthrustawayortiemoretightlyitisaverydiffic ultweightforonesoultolaborovertwopeopleasiamwrackedbypainforhertoomuchdisciplinecausesmoreharmthan pleasureandwarswithhealthipraisetoomuchlessthannothinginexcessandthewiseagreewithme *** Scene 1 Enter Phaedra and the Nurse; the former is recumbent on a couch while the latter bustles about her with gestures that might be those of a caregiver or a guard. NURSE Ills and hated diseases! What can I do for you? What should I not do? Here is the light, and the bright air; your sick bed is now outside the house. Your every word was to come here, but you will rush back to your bedroom again. You fade quickly. You delight in nothing. You dislike what you have. You love what you don’t. It’s better to be sick than tend the sick – the first is simple. To the second attaches heart’s pain and hand’s work. Every human life is painful. There is no end to toil. Darkness hides behind clouds whatever is dearer than life. We prove unhappy lovers of what shines here for lack of knowledge of another life. There is no proof for things beneath the earth. Only stories sustain us. PHAEDRA Lift my body, straighten my head: the bonds of my limbs are loosened. Take my hands and my pale arms. This hat is too heavy for my head to wear. Take it off, spread my hair over my shoulders. NURSE Courage, child; don’t toss and turn so violently. You will bear your sickness more easily with peace and a noble mind. All mortals suffer. PHAEDRA Aiai. I want to drink pure water from a dewy spring. I want to lie back and rest under the trees in some grassy meadow. NURSE Child, why cry? Don’t say these things near the crowd, hurling words mounted on madness. PHAEDRA Send me to the mountain. I will go to the forest where beast-killing dogs press the spotted deer. Gods! I long to shout to the dogs, to shoot the Thessalian javelin past my blond hair, to hold the barbed dart in my hand. NURSE Why this anxiety, child? What do you care about hunting? Why do you lust for flowing springs? There’s a hill with water just next to the tower; we can get you a drink there. PHAEDRA Artemis, mistress of the salt lake and the course thundering with horse’s hooves: I wish I were on your plains breaking studs! NURSE Why throw these frenzied words about? Just now you were setting out for the mountain to hunt – and now you long for horses on the waveless sand. These things need an oracle to tell which god reins you in and drives you from your senses, child. PHAEDRA What have I done? How far have I been driven from good thoughts? I was crazy, I was cursed by some power. Pheu pheu. Alas. Nurse, cover my head again. I’m ashamed of what I’ve said. Cover me – a tear moves down from my eye and it embarrasses me. It hurts to straighten your mind and it is terrible to be insane. Best to die before you become lucid again. NURSE I’ll cover you. But when will death cover me? I’m old; I’ve learned a lot. Mortals should drink of friendship moderately, not from the deepest marrow of the soul. A mind’s love-charms should be easy to undo, or thrust away, or tie more tightly. It is a very difficult weight for one soul to labor over two people, as I am wracked by pain for her. Too much discipline causes more harm than pleasure and wars with health. I praise “too much” less than “nothing in excess,” and the wise agree with me. ***. (shrink)

Harry G. Frankfurt’s work on agency and reflexivity represents one of the most important attempts in the current philosophical literature to elaborate the structure of agency. Frankfurt wishes to provide an account of what I call the “deep structures” of agency—those features of agency, such as care and love, in virtue of which the surface features, such as desire, are to be explained and understood. These deep structures are important because of their power to explain unified diachronic patterns in (...) our lives rather than just individual actions. In doing so, Frankfurt seeks to be a Humean in Aristotelian clothing: he desires the richness of a broadly Aristotelian moral psychology–specifically, an Augustinian variant of this—built out of the resources of a Humean human nature in which the “passions,” or here, those objects we care about, are fundamental. -/- Thus Frankfurt develops concepts such as second-order desire, identification and dissociation, wholeheartedness, and love without incurring significant metaphysical costs. Through these concepts Frankfurt provides an account with extraordinary richness. However, I argue that Frankfurt’s minimalism conflicts with his attempts to provide so rich an account of our moral lives. In particular, his attempt to make caring foundational for practical reason undermines his conception of identification and dissociation. Frankfurt’s Humeanism commits him to a tragic moral universe in which the dissociation of desire is little more than an exercise in self-deception rather than a means of guaranteeing psychic unity. -/- I then argue that a superior account of moral life and the moral self can be constructed through greater reliance upon Augustinian ideas concerning the nature of love that is rooted in two concepts: affinity and peace. The concept of affinity provides a basis for evaluating what is worth loving and the concept of peace, central to Augustine’s moral psychology, is used to analyze the structure of love itself in its many manifestations. This account is less minimalist than Frankfurt’s but is more faithful to our moral experience and provides a more powerful and nuanced analysis of moral life and the self. (shrink)

There are several features of Akkadian that set it apart from other Semitic languages. One such feature is the assumption of seven alefs that descended from Proto-Semitic phonemes, *ʔ, *h, *ʕ, *ɣ, *ħ, and sometimes *w and *j. The standard account is that they merged before being lost in nearly every environment. Additionally, ʔ3-5 interact with the low-back vowel, [a], producing [e]. Two other issues regarding the shift from [a] to [e] is which environments [e] surfaces in to be reanalyzed, (...) and the fact that there are several roots that have [e] and no apparent conditioning environment. In this article I provide a solution to these issues clarifying the conditioning environments obscured by Akkadian orthography and Semitic derivational morphology. I show that voicing assimilation alone is responsible for the different outcomes of *ħ and *ʕ, which have the same distribution. This assimilation has parallels in non-guttural roots such as *√ntn, which becomes √ndn in Akkadian. Whether *ʕ and *ħ surface as or depends less on the underlying form than on assimilation to the voicing value of the adjacent consonant radical. With this analysis, there is no reason left to reject Kowenburg’s theory that gutturals became glides which cause raising to [e], with the slight amendment that it is the voiced variant *ʕ alone which becomes a glide. (shrink)

Muslims are fundamentally interested in the practice of writing especially for scribing the copies of the Qur’ān. Later, the practice of scribing ḥadīths texts and writing diplomatic correspondence increased the demand for developing this practice. It is because the writing is based on a religious reference in Islamic societies; over time, the interest in writing and writing materials has also turned into an art form. Thus, writing and writing materials have been named with the selected words from the Qur’ān. Pencil, (...) book, pages (ṣuḥuf), line, stone tablet (alwāḥ) are some of the examples of those words. The writing constituted a series of professions. Calligraphers and warrāqs (book dealers/booksellers) are some examples in Islamic societies. Until the printing press became widespread, the books were written and reproduced by hand which is called istinsākh. Nowadays, these manuscripts are protected in libraries and digital archives. Codicology examines the external elements of these manuscripts such as ink, binding and paper. In addition, the critical edition method was used to bring out manuscripts to the surface. Critical edition of manuscripts is not only transferring the text to the computer. The critical edition is to compare manuscripts of work to reach the original text of the author. While doing this, the evaluation of the text has been held to reveal the historical value of it. In this article, the place of manuscripts in Islamic culture has been discussed and the basic principles of the critical edition, how to create the editing (dirāsa) and text (naṣṣ) sections of the critical edition are explained with examples. The examples were selected from the previous critical editions conducted by the author. This study aims to give an introduction to a very wide field of codicology and critical edition. This article is intended to provide basic information for researchers interested in codicology and critical edition.Summary: Classical Islamic writing culture has its method. For centuries, Muslims have written manuscripts according to this method. This method has been applied from writing the knowledge on paper to collecting and binding the fascicles.The adventure of creating a manuscript is a long process. A lot of people come around to contribute this process initiating from the writing of the first sentence. Producer of the knowledge: scientists, paper-producer: werrâq, the calligrapher: khaṭṭāṭ, bookseller, bookbinder, expert in the ink, naqqāsh who marbles the papers, sponsors of the project, collection and the librarian are some of the contributors. Today, this adventure continues with the participation of enthusiasts which are: the author who re-writes the manuscript to revive it, the restorer who repairs the damage of the manuscript, the expert who creates the digital copy and institutions which publishes the facsimile.Nowadays manuscripts are accepted as important scientific data and are examined in many ways other than their contents thus new specialities have been occurred. At universities, the institutes which examine manuscripts have been established and academic journals have been published. Moreover, the critical edition of manuscripts is the main subject of some of the M.A. and Ph.D. theses.The studies on critical edition, which initiated earlier in some of the western countries, have made a rapid development and created its method. In Turkey, there are many critical editions of works which are based on various manuscripts from Theology to Literature fields. However, there is no significant mutual method among the studies yet. Also, their understanding of critical edition differentiates. In those studies, it has to be examined that basic parameters such as the selection of convenient copy, access to all copies of manuscript or priority of copies are applied to critical edition process. Most of the time it is observed that the advisor’s way of the critical edition has shadows on studies. However, fundamentally critical edition process needs expert contribution itself. Difference between studies is related to the fact that the critical edition is relatively a new field of study in Turkey. Therefore, specific studies in the field of critical edition and codicology are still needed to be developed. On the other hand, there are various publications to establish an objective methodology of the critical edition. Significant studies are being held by the Center for Islamic Studies (ISAM) to establish a mutual language and method for critical edition studies. The factor that led to the emergence of this article is the effort to contribute to the realization of this method. The article discusses the principles to be followed during a critical edition process. Moreover, topics are explained practically with examples selected from manuscripts. Those examples have been chosen from the author’s previous critical edition works. The article would be considered as an “Introduction to Critical Edition” for the researchers who are new at this field. In this respect, the article aims to make a methodological contribution to the critical edition studies.There are many parts of a manuscript –something more than the written text on the page– which makes it a whole. These parts can be divided into internal and external elements of the manuscript. All of these are parts have different levels of contribution to the examination of the critical edition of the work and the interpretation of the texts.Some external elements of manuscript are: ink production and color, inkwell, production of paper, foliation, rule-borders, and frames, ruling board (misṭara), sewing of quires, gilt and gilding, bookbinding, stamping and tooling, frontispiece, cases and pouches, storage boxes and cabinets, flap, tabula ansata, the history of manuscript.The internal elements of the manuscript are: text of the manuscript, script, subject, authenticity, historical value and importance, proprietor, literary features, number of copies and textual variants, scribes and copyists, whether it has been falsified or not, sources used or referenced by the author, abbreviations, records of marginalia, colophon, glosses and scholia, ownership statements, seals and seal impressions, word transposition or transposition of words/letters, waqf-statements, correction signs and corrections, countermarks.While the internal elements of manuscript are the work of critical edition, the external elements of the text fall within the field of codicology. Although critical edition and codicology are considered as separate sciences, there are points where they can contribute to each other. For instance, the ink tone or binding style of a manuscript may help to determine the writing date range of it. The references used by the manuscript can give us an idea about the name or the subject of another manuscript. The literary characteristics of the manuscript may reflect the author's success in language and literature fields. Thus, we are able to inform that the critical edition process of a manuscript requires the evaluation of substantial information at the same time which is no different from an archaeologist carefully examining an arrowhead. Therefore, whatever is the relation between History and Archeology has; Islamic sciences have the same relationship with critical edition. They are both individual sciences with methods of their own and two inseparable common sciences. Thus, without the contribution of codicology or other sciences, rewriting a manuscript on a computer does not mean making a critical edition of it. According to this information, we can define the critical edition as follows, “Critical Edition is the process of reviving of any manuscript -which belongs to Islamic civilization- with comparison of all available copies to create a single text which is closest to the text of the author and to determine the sources which this main text is based, citations such as verses, hadiths and poetry.”For studies on critical edition, the priority should be given to the texts which will contribute to this science. Before initiating critical edition, the authenticity of the author of the manuscript should be determined precisely. Of course, having a person's name on the page is not enough for determination. All copies of the manuscript must be identified. From those copies, critical edition should be based on the text that the author has personally written or prepared as a draft and other copies should be compared with this. In the absence of the author’s authentic copy, new criteria will apply. For instance, the copy written by the closest student of the author or the copy with the closest writing date takes precedence over the copies with no date. After comparison of all copies, the differences are shown in the citation.Critical Edition consists of two sections entitled as Edition (Editing/Dirāsa) and Text (Naṣṣ):The Edition section includes: the author’s name, lineage, place and date of birth, scientific life of the author and his/her prominent students, works, the authentication document which is proven that the text is belong to the author, the place of the work in the history of science, studies about the work, bibliography, literary characteristic, terms in the text, the amount and characteristics of the copies, the characteristic of the main copy which is determined as the fundamental text for the research, the rules and principles applied during the critical edition, the digital images of the first and last pages of the copies used. The Edition section is the part that demonstrates the reliability of the study. All external elements of writing are being introduced here. The importance of the text is confirmed by this edition process. Thus, the final shape of the edition section must be shaped by reading and understanding the text.In the text section, the main aim is to reach the very first text which has been written originally by the author. In this section, principles of morality and objectivity are followed. The text is preserved; additions or subtractions are not made. Cited sources at the manuscript are being found. Verses and ḥadīths are written with their sources. Poems are found in Dīwāns. Text is made legible with punctuation and pilcrow. Proper names, dates of death are written together. Page numbers in the manuscript are shown in square brackets. Some simple grammatical errors are corrected without interfering with the main text. Mostly the reason for this is the letters used for men or women. At the end of the study, a bibliography with all the resources used during the critical edition process is added. The Islamic codicology and manuscripts appear to receiving interest especially in academic studies. Considering that many manuscripts from the Ottoman Era are still waiting to be revived thus, we may come across profound critical edition works in the near future. Therefore, it is understood that individual studies related to the manuscript itself and the method of the critical edition will guide the researchers. (shrink)

This article is an inquiry into the discourse phenomenon of grounding, viz. the foreground-background structure. It explains the place of the phenomenon in the structure of discourse and provides evidence of grounding from short news items. Focusing on the surface structure level of discourse organization, the article examines variant marking of the FG-BG articulation at sentence-initial position. Using English and Arabic news data, the article explicates the grounding-signalling function of entities that appear in that position and shows that (...) Arabic news texts rely on certain prefatory expressions to signal the grounding values of underlying propositions. The study underscores the influence of the cognitive level of information on grounding and its marking in the hierarchical structure of discourse. (shrink)

To understand H.L.A. Hart's general theory of law, it is helpful to distinguish betweensubstantiveandmethodologicallegal positivism. Substantive legal positivism is the view that there is no necessary connection between morality and the content of law. Methodological legal positivism is the view that legal theory can and should offer a normatively neutral description of a particular social phenomenon, namely law. Methodological positivism holds, we might say, not that there is no necessary connection between morality and law, but rather that there is no (...) connection, necessary or otherwise, between morality and legal theory. The respective claims of substantive and methodological positivism are, at least on the surface, logically independent. Hobbes and Bentham employed normative methodologies to defend versions of substantive positivism, and in modern times Michael Moore has developed what can be regarded as a variant of methodological positivism to defend a theory of natural law. (shrink)

Knill, Kersten, & Mamassian (Chapter 6) provide an interesting discussion of how the Bayesian formulation can be used to help investigate human vision. In their view, computational theories can be based on an ideal observer that uses Bayesian inference to make optimal use of available information. Four factors are important here: the image information used, the output structures estimated, the priors assumed (i.e., knowledge about the structure of the world), and the likelihood function used (i.e., knowledge about the projection of (...) the world onto the sensors). Knill & Kersten argue that such a framework not only helps analyze a perceptual task, but can also help investigators to define it. Two examples are provided (the interpretation of surface contour and the perception of moving shadows) to show how this approach can be used in practice. As the authors admit, most (if not all) perceptual processes are ill-suited to a "strong" Bayesian approach based on a single consistent model of the world. Instead, they argue for a "weak" variant that assumes Bayesian inference to be carried out in modules of more limited scope. But how weak is "weak"? Are such approaches suitable for only a few relatively low-level tasks, or can they be applied more generally? Could a weak Bayesian approach, for example, explain how we would recognize the return of Elvis Presley? The formal modelling of human perception To help get a fix on things, it is useful to examine the fate of an earlier attempt to formalize human perception: the application of information theory. It was once hoped that this theory—a close cousin of the Bayesian formulation—would provide a way to uncover information-handling laws that were largely independent of physical implementation. In this approach, the human nervous system was assumed to have.. (shrink)

continent. 2.1 (2012): 6–21. The French philosopher and novelist Tristan Garcia was born in Toulouse in 1981. This makes him rather young to have written such an imaginative work of systematic philosophy as Forme et objet , 1 the latest entry in the MétaphysiqueS series at Presses universitaires de France. But this reference to Garcia’s youthfulness is not a form of condescension: by publishing a complete system of philosophy in the grand style, he has already done what none of us (...) in the older generation of speculative realists has done so far. His book is sophisticated, erudite, rigorous, imaginatively rich, and abundant in worldly wisdom– despite the author’s conclusion that wisdom does not exist. The quality and scope of Forme et objet took few observers by surprise, since Garcia has been treated as an emerging philosopher to watch across half a decade of Parisian oral tradition. But Garcia was not just the subject of rumor, being already well known to the French public as a writer of fiction. His debut novel, La meilleure part des hommes , 2 was awarded the 2008 Prix de Flore 3 and has already appeared in English as Hate: A Romance . 4 His follow-up novel, Mémoires de la jungle , 5 made clever use of a chimpanzee narrator. Nor was Garcia only published as a novelist before last November: his philosophical study L’Image 6 had already appeared when the author was just twenty-six, a year before he was crowned by the muses at the historic Café de Flore. And then in 2011, just months before the appearance of Forme et objet , Garcia published a widely distributed work entitled Nous, animaux et humains , 7 with its focus on Jeremy Bentham’s ideas about animals. Given this prolific and versatile track record, an optimistic scenario might envisage the young Garcia as one of those combined literary/philosophical talents who appear intermittently in France across the centuries: Jean-Paul Sartre is merely the most famous recent case. While more time is needed to see how Garcia will channel his impressive mental energies, Forme et objet displays such breadth of insight that its author has a good chance to emerge as one of the leading philosophers of his generation. If we accept Aristotle’s dictum that the peak mental age is fifty-one, then to read Garcia’s massive book is to gain some idea of what European philosophy might look like in the futuristic-sounding 2030’s. The present article is confined to Forme et objet . At 486 pages, the work is obviously daunting in size. Indeed, it is even longer than it sounds, given that many of its early sections are printed in a smaller typeface to designate them as supplemental commentary to the main flow of the argument. But while the length of the book reportedly led to delays in French publication, and will probably slow the inevitable appearance of an English translation, the length of the book should not deter interested readers– much of it results from Garcia’s teacherly writing style. Whereas Quentin Meillassoux’s prose displays an arctic economy of means, Garcia’s style is reminiscent of the repeated lessons of oral classroom proceedings. Rarely is the reader given fewer than three or four chances to master an idea before the author moves on to the next. In practice, the style feels welcoming rather than long-winded. Otherwise, the structure of Forme et objet is surprisingly simple. There is a useful Introduction of less than twenty pages. Then comes Book I: Formally , running to approximately 135 pages. Here Garcia outlines the most basic features of a thing “no matter what it is,” or n’importe quoi , an everyday phrase that Garcia shapes into a technical term. This part of the book feels at times like a more amiable version of Hegel’s Science of Logic , a parallel emphasized further by the threefold articulation of its theme: 1. Thing; 2. Thing and World; 3. Being and Understanding. This is followed by the much longer Book II: Objectively , totaling more than 300 pages. It contains sixteen essay-like meditations on specific kinds of objects—including time, animals, humans, history, gender, and death. Here each chapter rolls smoothly into the next, making this second part of the book feel more like a different work of Hegel: The Phenomenology of Spirit . But these are merely analogies. Garcia is no Hegelian, even if the book contains a few dialectical flourishes that seem to reflect his early enthusiasm for the Frankfurt School. Forme et objet ends with a six-page Coda, followed by the usual page of acknowledgments. In what follows, I will briefly summarize each of these four parts of the book before ending with some more general remarks. Before doing so, it will be useful to situate Garcia biographically (as much as I am able) and philosophically. Though Toulouse is his native city, his formative years were spent largely in Algeria, where his family has deep roots. During our sole private conversation, Garcia mentioned that his parents are professors of literature. 8 As a student of philosopher Garcia flourished so early that many of his current ideas date to his teenaged years: “There are sentences in Forme et objet that I wrote when I was seventeen,” he said in response to a question on that cold night on the Canal St.-Martin. I recalled that remark when reading his brilliant account, late in the book, of the central role of adolescence in contemporary culture. While many prodigies blow through their formal academic training without serious obstruction, Garcia’s student memories are rich in tales of isolation and struggle, though equally rich in gratitude for a half-dozen or so exceptional teachers who provided the intellectual space he needed: Meillassoux and Alain Badiou are simply two of the most prominent figures on that list. Though there are many points of agreement between Garcia’s philosophical position and my own, he not only reached his position years before reading my work, 9 he arrived along a rather different path: not through phenomenology, but via the Frankfurt School, which may be one of the reasons for his profound fascination with aesthetics. Garcia’s cultural background is as broad as one could wish: he is no less informed about punk rock and European football leagues than about the spiritualist roots of Bergson’s philosophy. Curious about everything and contemptuous towards nothing, Garcia can be expected to write insightfully on dozens of topics in the years to come. Given that his philosophy is so personally tantalizing in its agreements and disagreements with my own, and given the great internal richness of Forme et objet itself, the present review is no better than a first effort at coming to terms with the challenges posed by this minstrel from the rising generation. This is especially intriguing for older Generation X’ers like me, since confrontation with the younger generation is one of the many themes treated insightfully in Garcia’s book. 1. Introduction Garcia begins in defense of a so-called “flat ontology,” in which all things are equally things. While Roy Bhaskar 10 used this term pejoratively to refer to anti-realist philosophies that flatten everything onto an epistemic plane of human access, Manuel DeLanda 11 (an admirer of Bhaskar) reversed it into the positive principle that all realities are equally realities. Similar notions can be found in the “absistence” of Alexius Meinong, 12 the “irreduction” of Bruno Latour, 13 and my own critique 14 of the undermining/overmining pair. Also noteworthy is Levi Bryant’s use of the term “flat ontology” throughout The Democracy of Objects 15 and his earlier essay “The Ontic Principle.” 16 But for Garcia, flatness is only one face of the cosmos, and one that he ultimately declares to be rather impoverished. Even so, he always remains an advocate of a flat ontology. Insofar as everything is equally something, no matter what it is ( n’importe qui ), everything is equally a thing, equally solitary in its relation with world. This is why his book abounds in those long lists of random, ontologically equivalent entities that Ian Bogost has playfully termed “Latour Litanies.” 17 The first litany in Garcia’s book runs as follows: “We live in this world of things, where a cutting of acacia, a gene, a computer-generated image, a transplantable hand, a musical sample, a trademarked name, or a sexual service are comparable things.” (7) Yet Garcia is frankly dualistic; his flat ontology only lasts until page 159 and the end of Book I (entitled “Formally”), which deals entirely with things that are equally things. Thereafter Garcia turns his attention from things to objects, which are not flat in the least, but engage in hierarchical relations with one another. In agreement with both DeLanda and the speculative realists, Garcia proclaims that his book “proposes to put to the test a thought about things rather than a thought about our thought about things .” (8) Just as ducklings are “imprinted” (9) after hatching and treat the first creature they see as their mother, philosophers are imprinted by the idea with which they begin. Hence, philosophies that begin with human access will never truly find their way back to things. This makes Garcia rather suspicious of twentieth century philosophy, since “the twentieth century—to which in some way this work proposes to bid adieu—has been a period of theorizing modes of access to things rather than things...” (9) Among other possible benefits of the philosophy of things that Garcia proposes, it is fully able to account for thought as a special variant of things, while the reverse is not possible.(10) In Book I of Forme et objet , Garcia’s “things” are so flat, so de-determined, that he is forced to renounce some of the most basic features ascribed to things by most realists. As he tells us in his foreboding third footnote: “We will maintain that the solitude [of things] is less than unity, less than identity, and that it does not imply acceptance (any more than refusal) of the principle of non-contradiction.” (11) In a contemporary world cluttered with too many things, Garcia’s flat and formal plane provides us with some breathing room: “The formal plan of thought enables or re-enables us to cut short all accumulation—whether of knowing, experience, or action—by a simplicity, an impoverished surface...” (13) As Garcia says elsewhere in responding to a Deleuzian critic of the book, his starting point in flat ontology is designed to obstruct the claims of both analytic philosophy and Hegelianism: “Hence, this work seeks to protect each thing—real, imaginary, inconsistent, contradictory—both against Ockham’s Razor and against the Aufhebung or dialectical process.” 18 Yet contrary to the equalizing spirit of many flat ontologies, “we will add to our formal ontology of the equal, an objective ontology of the unequal.” (13) But initially, Garcia joins all flat ontologists in holding that everything is irreducible: “this irreducibility, which we will term the ‘chance’ of each thing... also marks the refusal of a positive thought that reduces things exclusively to natural things, or social things, or historical things, etc.” (15) This irreducible “chance” of a thing emerges as an important technical term in the book, always paired with its inverted brother, the “price to pay” ( prix à payer ). On pages 17-19, we find the only diagrams in the book. What they illustrate is that Garcia wishes to avoid two equally dangerous extremes. The first is the philosophy of substance, featuring the thing-in-itself as a mighty river fed by attributes as if by subordinate tributary streams. This model can be found in many of the classic thinkers of West and East alike. In it, “there is obviously a hierarchization between that which is dragged towards something other than itself, and this other which serves it as an ontological support while supporting its proper being.” (16) For Garcia, the second extreme worth avoiding is the philosophy of events: “One thus conceives trajectories of being, identified as events, facts, powers, intensities, or intentionality. These vectors of being come first, bearing and supporting being, displacing it, but without ever finding a stopping point, a buffer, an objective consistency.” (17) The first model gives us a thing too wrapped up in itself, too compact . This word “compact” (the French and the English are the same) is another technical term for Garcia. But if the “compact” model of things leads us to something more than things, the philosophy of events gives us less than things, by dissolving them into a play of vectors. Garcia’s alternative lies midway between these two extremes: Being enters the thing, being comes out of it. And a thing is nothing other than the difference between the enters and the being that comes out. Thus, the circuit of being is never halted. In the thing, there is never the thing-in-itself. And the thing is never in-itself, but outside of itself. Nonetheless, being is not eventally “pollinated” by vectors: it possesses an objecting halting-point... (19) This single idea is the key to Garcia’s book: the thing is neither a self-contained durable lump nor some sort of evental flux. Instead, the thing is the difference between its various components and its relations with its environment. Or stated differently: “the price to pay for this disposition is a circulation of being that systematically distinguishes two senses of things: that which is in the thing , and that in which the thing is , or that which encompasses it and that which it encompasses,” (19) translating comprendre here as “encompass.” 19 In a beautiful description of a piece of black slate, Garcia sums up the various minerals, qualities, and shapes that compose [ comprend ] it, and calls them “that which is in the thing,” (20) noting that this tells us nothing about “that in which [the slate] is”—namely, all the various situations in which the black slate can be found. Instead, the slate is the difference between these two: the most characteristic principle of Garcia’s philosophy. 2. Formally Book One of Forme et objet , “Formally,” is concerned with the formal equality of all things in a flat world. “Two questions mark the boundaries of reflection: of what is everything composed [ composé ], and: what do all things compose?” (27) Looking downward, we wish to know what everything is made of; looking upward, we want to know the ultimate result of the combination of all things. Here we must turn our attention to the thing n’importe quoi— no matter what it is. (30) Anything with finite qualities is obviously too specific to be relevant to global ontological questions. To an equal degree, something possessing all qualities (think of Whitehead’s God) 20 would not be n’importe quoi either, since it would still be too definite, even if incredibly vast. The same holds for contradictions, since these all differ from each other. The square circle, the non-white black white, and the non-city city are all too distinct to count as the thing no matter what it is. The n’importe quoi must be devoid of all specific qualities, including contradictory ones. In one of the more intriguing points in his book, so reminiscent of Meinong, Garcia proclaims that “the ‘no matter what it is’ is neither a reality nor an abstract construction, nor both of these at once; the ‘no matter what it is’ is simply the plane of equality of that which is real, that which is possible, that which is inexistent, that which is past, that which is impossible, that which is true, that which is false, that which is bad.”(39-40) Since everything has two faces, it would be a grievous mistake to focus on just one of them at the expense of the other, as physicalism or materialism do when reducing the world to minuscule physical underpinnings. For scientistic materialism, “it is either atoms, particles, or fields of force... which are the things.” (47-48) Moreover, “these more-than-things are accompanied by less-than-things: for example, ideas or facts of consciousness are determined by the state of matter and are not autonomous things, but manifestations reduced to secondary effects of material processes...” (48) On this point, Garcia’s position is in complete accord with my own critique of undermining and overmining. 21 Where we disagree is that Garcia is more deeply suspicious of the notion of substance, which I view as salvageable with a few needed changes, while Garcia sees this operation as hopeless: “A substance, in the history of philosophy, is the more-than-thing par excellence.” (51) Another agreement between our positions is visible when Garcia claims (correctly, in my opinion) “that it is vain to distinguish between things which are material and those which are not.” (52) Yet we also find an even more important disagreement, since for Garcia withdrawal cannot be the quality of a thing. Instead, the absence of a thing is simultaneous with it, embodied in all that is not it– the absence of the sculpture of a woman is to be found in the mold that appears at the same time as it, and thus withdrawal must be viewed as an “event” rather than as something pertaining to an object. For Garcia, nothing withdraws beyond access. Since we must distinguish between “that which is something” and “that which something is,” and since the former is identified with “no matter what it is is” and the latter with “ not no matter what it is,” we can say that “everything is thus a milieu, a fragile link between ‘no matter what it is’ and ‘ not no matter what it is.’” (62) And here we find Garcia’s critique of the thing-in-itself: “A thing is never defined en bloc . We can affirm that a thing is this or that, but that does not suffice. It is still necessary to state precisely that which is this thing .” (62) Stated differently, “something is not in itself : for that which is in the thing is not the thing, and that in which the thing is is not the thing.” (62) And here Garcia and I, facing the same evidence, draw opposite conclusions. For me, the fact that nothing can be identified with either its components or its concrete location means that the thing must be something in-itself distinct from both of these. Yet for Garcia, to be in-itself would mean to be identified with just one of these two extreme terms, and hence the thing can only be the difference between them. Garcia is equally suspicious of the classical tendency to view “unity” as a property of the thing, since in his eyes unity is too relational a property to belong to things. (65) While specific things are situated determinately with respect to other things, we are still speaking here about the thing no matter what it is, and this can be viewed only in terms of solitude, which all things share: a human being, a hand, or a chair or all equally things insofar as they are on their own , not insofar as they are one . (64) A thing is alone, and relates only to the one thing that is not another thing: world. In a striking parallel to my own argument for a partial revival of occasionalism, Garcia tells us that “the things communicate only by their solitude: it is because everything is equally on its own in the world that things can be together, enmeshed in one another.” (67) Alone in their solitude, things all relate to world, which serves as a mediator allowing them to become mixed up in one another. As we have seen, one reason that nothing can be in itself is because everything is in something else. For Garcia, “to be in something and to be something are equivalent.” (69) Stated more broadly, “being is thus the difference between the two aspects of each thing: that which is it, and that which it is.” (70) And even more vividly: “a thing is almost like a sack: there is that which one puts in the sack and that which remains outside the sack.” (70) But not quite like a sack, “since a thing is not a thin skin or film. Instead, a thing is comparable to a sack that is immaterial and without thickness: it is nothing other than the difference between that which is this thing and that which thing is, between content and container.” (71) Nothing can be in-itself because everything is two selves at once. For example, we cannot say that our self is defined by our consciousness: “Everything has a self because nothing is in itself. The self is not the quality of that which is related to itself (which is conscious, for example) or which thinks itself related to itself. Nonetheless, for an entity called ‘conscious’ to be related to itself, it is necessary that this very relation should be another thing than the self to which it is related.” (71) Consciousness cannot be the self, precisely because it is other than that of which it is conscious. Nothing is able to grasp itself. The self is “the function by which being and composition [ compréhension ] are mutually excluded...” (72) The self is “the point of shadow of everything that projects some light...” (72) The in-itself faces two opposite dangers: “For something to be in-itself is to be a self. Something which is a self flies out through one of its two sides... Stated differently, being in-itself is simply the possibility of a double failure.” (73) The in-itself can be termed compact : “There remains to us a means of thinking that which does not fully enter into the world, though without exiting from it. This means is what we call the compact.” (76) In a sense, the compact is the opposite of the world. For in the case of the world, everything enters it and it enters nothing; as for the compact, it enters the world (since it is something, after all) while nothing enters it. (77) The compact marks the presence of the impossible in the world. (78) It is not impossible, but possible only on the condition that it fails. (78) The time has come to speak of where a thing is located. “The sole condition of a thing is that of being in another thing than itself, and thus in another thing than something.” (78) A condition is “that which determines something, that which forms something, that in which something is.” (78) As for humans, “the condition of someone is his situation; my social condition is that which socially determines me, my place and my function...” (79) More generally, “to be conditioned is to find oneself reduced to that in which one is.” (79) Everything is conditioned, but nothing is reducible to this condition. To determine the condition of something is to determine in what it is. A thing is located in that which contradicts it, just as a statue exists in its mold, which is precisely that which it is not. Since the thing is finite and definite, its condition or form must be infinite and indefinite. That in which all things are is the world, which Garcia also terms “the whole.” (81) “To try to be in-itself is to attempt to remain outside the world. And indeed, to try to be in-itself is only a path of entry into the world.” (83) For Garcia, “the world is not the pre-existent container of the things it contains, a priori , nor the construction by the mind of a fictional ensemble of all things, a posteriori .” (85) Instead, the world is simultaneous with all things; the two always go together. The world cannot be a determinate world, such as the physical universe or mathematical space, since these are already too specific and limited. “Every determinate world, which is in fact a universe , is a ‘big thing’ [ grosse chose ]: it is a set, however vast, of composite things which itself embodies a thing.” (85) Every determinate world is really just a “big thing.” Stated differently, “it is nothing other than a balanced milieu between the things that compose it and the thing that it composes.” (85) We generally picture the world as a physical univer. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Altars Altered: The Alexandrian Tradition of Etymological Wordplay in Aeneid 1.108–12Pamela R. Bleisch*In his recent monograph True Names: Vergil and the Alexandrian Tradition of Etymological Wordplay (1996) James J. O’Hara discusses what he terms “naming constructions as etymological signposts”; these are points in the text where Vergil calls attention to etymological wordplay by his use of words such as nomen, cognomen, verum nomen, voco, dico, appello, or perhibeo (75–79). (...) O’Hara remarks on a few passages which feature naming constructions even though no etymologizing seems to be involved, and notes Aeneid 1.108–10 as one such example:tris Notus abreptas in saxa latentia torquet (saxa vocant Itali mediis quae in fluctibus Aras, dorsum immane mari summo)....The South wind snatched up and hurled three ships onto the rocks hiding in midocean, the rocks which the Italians call Altars, a huge spine on the surface of the sea....The naming construction here—vocant Itali, “the Italians call”—is pronounced, but the etymologizing wordplay has escaped the attention of Vergil’s readers. O’Hara comments: “This is not quite etymologizing, but Vergil uses the naming signpost to call attention to the name of these rocks: Arae, Altars” (78). I would in fact argue that this passage of the Aeneid prominently features etymologizing, of the type which O’Hara elsewhere in his monograph calls “translation with paronomasia” (63). Vergil’s Arae, “Altars,” plays on the Greek arai, “curses, bane, ruin.” 1 According to Servius, the Greeks called these rocks Bomoi, “Altars” (Serv. Auct. on Aen. 1.108). Vergil, by glossing the Italian name [End Page 599] from a Greek vantage point, alters Bomoi into Arai, “Altars” into “Curses.” The word latentia, “hiding,” in line 108 alerts Vergil’s audience to be on the lookout for hidden meanings, while the repetition of saxa, “rocks,” in lines 108 and 109 highlights the double entendre of the proper name. The phrase vocant Itali serves as a signpost for the punning etymology, for it raises the issue of foreign language and translation.In Vergil’s punning etymology at Aeneid 1.108–10 the naming construction serves as the gloss itself; Itali calls the reader’s attention to the etymological translation with paronomasia. O’Hara cites another example of this in the Georgics: navita tum stellis numeros et nomina fecit / Pleiadas, Hyadas, claramque Lycaonis Arcton, “Sailors then gave numbers and names to the stars: Pleiades, Hyades, and the illustrious Bear, Lycaon’s daughter” (1.137–38). “By saying it was sailors who named the Pleiades and Hyades, Vergil takes a stand, as it were, and suggests the etymology from sailing for both words” (p. 78). The Itali in Aeneid 1.109 play an analogous role to the navita in Georgics 1.137; the subject of the naming construction simultaneously points to an etymological riddle and provides the clue to its solution.In Aeneid 1.109 Vergil plays on the name Arae/Arai; he also plays on an alternate name for the Arae, found in Sinnius Capito: hippou nota, the Horse’s Back (Serv. Auct. on Aen. 1.110). O’Hara notes: “In Vergil’s line 110, dorsum is an allusion to this other name, Back; Vergil says, in effect, ‘I am deliberately calling these rocks not “Back,” as some do, but “Altars”’” (78). By playing with the Greek name Horse’s Back, O’Hara argues, Vergil takes a stand on the etymology of these rocks. He is right to characterize Vergil’s allusion to hippou nota as a correction, but he misconstrues its rhetorical force. Vergil does not assert the authority of the Italian name; rather, he signals the Italian name as a variant, and privileges the Greek as the natural, dependable, true name: “the rocks which the Italians call Altars, that is: the Horse’s Back.” This is a bit like saying: “the dish which the Italians call polenta, that is: grits.” One culture is marginalized, while the other is assumed as the norm. The absence of a naming signpost with the word dorsum reasserts the authority of the Greek name Horse’s Back, while the phrase vocant Itali defines the Italian name as foreign.Both of Vergil’s wordplays... (shrink)

What happens when we blur time and allow ourselves to haunt or to become haunted by ghosts of the past? Drawing on archaeological, historical, and ethnographic data, Blurring Timescapes, Subverting Erasure demonstrates the value of conceiving of ghosts not just as metaphors, but as mechanisms for making the past more concrete and allowing the negative specters of enduring historical legacies, such as colonialism and capitalism, to be exorcised.

This study aims to explore librarians’ motivating styles in virtual information literacy instruction sessions based on participating students’ perception. The research method use a quantitative approach, involving a survey method was applied for this study. The survey was conducted involving a sample of 250 students who had attended the virtual information literacy sessions at the selected library. The questionnaire was distributed electronically using Google Form and it comprised of open-ended questions to provide responses regarding the motivation provided by librarians in (...) virtual literacy instruction. The study identified three stages of the virtual information literacy instructions in which librarians applied different motivational styles. The three learning processes: Greeting and Welcome, Core, and Wrap up, each provided evidence of motivating styles. The findings of this investigation are useful to practicing librarians as they can focus on motivating students during the virtual information literacy instruction. (shrink)

In order to maximize human performance, defence forces continue to explore, develop, and apply human performance enhancement (HPE) methods, ranging from pharmaceuticals to (bio)technological enhancement. This raises ethical, legal, and societal concerns and requires organizing a careful reflection and deliberation process, with relevant stakeholders. We discuss a range of ethical, legal, and societal aspects (ELSA), which people involved in the development and deployment of HPE can use for such reflection and deliberation. A realistic military scenario with proposed HPE application can (...) serve as a starting point for such an iterative and participatory process. Stakeholders can discuss this application, modify its features, and design appropriate processes around it – for instance, procedures for informed consent. We propose that organizing aspects into these three categories – ethical, legal, and societal – can help involve appropriate interlocutors at different moments: legal aspects with people in strategy or management roles, from the start of a project; ethical aspects with people in operations and medical roles, during development; and societal aspects with people in communication and personnel roles, during deployment. Notably, we developed and discussed this framework and the three aspects in close collaboration with personnel from the military. (shrink)