Brain mapping studies using dynamic imaging methods demonstrate areas regional cerebral blood flow (rCBF) decreases, as well as areas where increases, during performance of various experimental tasks. Task holds for both sets of cerebral blood flow changes (CBF), providing the opportunity to investigate areas that become and “activated” in the experimental condition relative to control state. Such data yield the intriguing observation that in areas in emotional processing, such as the amygdala, the posteromedial cortex, and the ventral anterior cingulate cortex, (...) although flow as expected during specific emotion-related tasks, flow decreases performance of some attentionally demanding, cognitive tasks. Conversely, in some of the areas that appear to subserve cognitive functions, as the dorsal anterior cingulate and the dorsolateral prefrontal cortices, increases while performing attentionally demanding cognitive tasks, but during some experimentally induced and pathological emotional Although the specific nature of such reciprocal patterns of regional remains unclear, they may reflect an important cross-modal interaction during mental operations. The possibility that neural activity is less in areas required in emotional processing during some higher cognitive processes holds implications for the mechanisms underlying interactions cognition and emotion. Furthermore, the possibility that neural in some cognitive-processing areas is suppressed during intense states suggests mechanisms by which extreme fear or severe may interfere with cognitive performance. (shrink)

Moran conceives of conscious belief as a conscious activity, rather than awareness of a mental state. Once conscious belief is understood in this way, the notion of suppressed belief becomes problematic. In this paper, I draw on the work of Merleau-Ponty to sketch an account of suppressed belief. I suggest that suppressed beliefs should not be understood as attitudes towards propositions. Instead, they should be conceived as ways of perceiving and interacting with the world that are out of keeping with (...) how one repre-sents it as being. (shrink)

Analysis of the U.S., Canadian and English approaches to excluding illegally obtained real evidence, which passes the threshold test of authenticity, probative value and relevance, reveals various ways in which poisoned truths are treated in criminal legal systems. A person who has no interaction with the criminal legal system may of course be considerably sympathetic to the English rule which attempts always to reveal the immediate truth. For if one considers only an individual criminal case, the English rule certainlyappears to (...) value truth above all else. However, a contextual analysis makes it clear that there is a systemic effect in always revealing the truth that may result in fewer incidents of the truth being revealed in the future than if the immediate truth were suppressed in a particular case. The U.S. and Canadian exclusionary rules recognize the systemic harm of automatically revealing all truths the moment the truths become apparent. While the U.S. courts have had trouble agreeing on the rationale for excluding illegally obtained real evidence, they have come up with a rule which in the end balances the immediate harm of exclusion of the truth and the systemic harm of its inclusion. The U.S. rule is also very predictable, clearly setting out when a future truth is threatened by revealing an immediate truth. The Canadian rule is in the early stages of development, and, while there is a clearly stated rationale that seeks a justice of truth, it is not sufficiently concrete to allow one to predict when the rationale of a justice of truth will be achieved. In the final analysis, and in contrast to the English exclusionary rule, both the Canadian and U.S. rules address thesystemic harm of always including illegally obtained real evidence. (shrink)

The attentional blink (AB) is an impairment of attention, which occurs when subjects have to report a target stimulus (T2) following a previous target (T1) with a short delay (up to 600 ms). Theories explaining the AB assume that processing of T2 is more vulnerable to decay or substitution, as long as attention is allocated to T1. Existing models of the AB, however, do not account for the fact that T2 detection accuracy reaches the minimum when T2 is presented after (...) about 300 ms and not immediately following T1. Therefore, a new model is suggested, which is based on chronometrical considerations together with recent neurophysiological findings concerning the relation between the P3 event-related potential and the AB, the interaction between P3 and gamma oscillations, and the significance of the early evoked gamma band response. We hypothesize that suppression of the early gamma response to T2, accompanying the P3 related to T1, causes the AB. (shrink)

Emotion suppression has been found to have negative psychological and social consequences in Western cultural contexts. Yet, in some other cultural contexts, emotion suppression is less likely to have negative consequences; relatedly, emotion suppression is also more common in those East-Asian cultural contexts. In a dyadic conflict study, we aim to conceptually replicate cultural differences found in previous research with respect to the prevalence and consequences of emotion suppression,and extend previous research by testing whether cultural differences (...) are larger for some than for other types of negative emotions. We postulate that cultural differences in suppression are less pronounced for socially engaging emotions than socially disengaging emotions, because the former foster the relationship, whereas the latter emphasize individual goals. Belgian and Japanese couples engaged in a 10-min conflict interaction followed by video-mediated recall, during which participants rated their emotions and emotion suppression every 30 s. As predicted, Japanese participants reported more suppression than their Belgian counterparts, but the cultural difference was more pronounced when participants experienced more socially disengaging emotions than when they experienced more socially engaging emotions. These results suggest that the type of emotion should be considered when describing cultural differences in emotion suppression. Finally, and consistent with previous research, emotion suppression was negatively associated with interaction outcomes in Belgian couples, but not in Japanese couples. (shrink)

This article describes interactional features of an interrogation method that is used by law enforcement and private security companies in the US known as the ‘soft accusation’ method. We demonstrate how the method, in contrast to the more common ‘story solicitation’ method, makes use of a ‘telling about oneself ’ activity to actually suppress a subject’s talk by setting up and maintaining an exceptionally long turn by the interrogator. This turn not only constrains subjects’ speaking contributions to the issuing of (...) continuers and acknowledgments, and, as such, their opportunities to challenge or resist, but, based as it is on ‘telling about oneself ’, re-organizes the knowledge differential to one in which it is the interrogator rather than the subject who has primary epistemic rights of disclosure. We provide an overview of interactional problems associated with the story solicitation method and then consider how the soft accusation method is designed to counter them, particularly via practices of informing and describing that are associated with the activity of ‘telling about oneself ’. As we show, these practices make use of techniques of elaboration that provide a resource for turn expansion, as well as for seamless topical movement that works to positively align the subject to the interrogator’s talk and, thus, to smooth the interactional pathway to the subject’s admission of guilt. (shrink)

In plants, virus‐derived double‐stranded RNA is processed into small interfering (si)RNAs by RNAse III‐type enzymes. siRNAs are believed to guide an RNA‐induced silencing complex (RISC) to promote sequence‐specific degradation (or ‘slicing’) of homologous viral transcripts. This process, called RNA silencing, likely involves Argonaute (AGO) proteins that are known components of plant and animal RISCs. Plant viruses commonly counteract the silencing immune response by producing suppressor proteins, but the molecular basis of their action has remained largely unclear. A recent study by (...) Zhang and colleagues1 now shows that the 2b suppressor of Cucumber mosaic virus directly interacts with Arabidopsis AGO1 and inhibits its slicing activity, suggesting that AGO1 might be a component of the elusive plant antiviral RISC. BioEssays 29:319–323, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks (DSBs) and suppress the demise of unstable replication forks. Our work elucidated a dynamic interplay between BRCA2 and the WRN DNA helicase/exonuclease defective in the premature aging disorder Werner syndrome. WRN and BRCA2 participate in complementary pathways to stabilize replication forks in cancer cells, allowing them to proliferate. Whether the functional overlap of WRN and BRCA2 (...) is relevant to replication at gaps between newly synthesized DNA fragments, protection of telomeres, and/or metabolism of secondary DNA structures remain to be determined. Advances in understanding the mechanisms elicited during replication stress have prompted the community to reconsider avenues for cancer therapy. Insights from studies of PARP or topoisomerase inhibitors provide working models for the investigation of WRN's mechanism of action. We discuss these topics, focusing on the implications of the WRN‐BRCA2 genetic interaction under conditions of replication stress. (shrink)

Ventricular Fibrillation is responsible for a majority of sudden cardiac death, but little is known about how ventricular tachycardia (VT) degenerates into ventricular fibrillation. Several clinical studies focused only on preventing VT with a class III antiarrhythmic drug resulted in many deaths. Our simulations investigate the interactions between an antiarrhythmic drug likely to suppress a VT and a Figure 8 reentry. A parameter AAR is introduced to increase the action potential duration and therefore simulate various Class III drugs. Simulations (...) are ran under several conditions (phases of the reentry, values of AAR, durations). They show that a VT can be suppressed whatever the phase of the reentry but it strongly depends on the duration of the effect. It confirms that a drug which can suppress a reentry can also worsen it. It also shows a great variety of activation patterns and thus the complexity of antiarrhythmic drugs effects. Simulations also demonstrate that suppressing VT is an increasing function of AAR. (shrink)

The current research investigates the interaction between thought suppression and individuals’ explicit awareness of their thoughts. Participants in three experiments attempted to suppress thoughts of a prior romantic relationship and their success at doing so was measured using a combination of self-catching and experience-sampling. In addition to thoughts that individuals spontaneously noticed, individuals were frequently caught engaging in thoughts of their previous partner at experience-sampling probes. Furthermore, probe-caught thoughts were: associated with stronger decoupling of attention from the environment, more (...) likely to occur under cognitive load, more frequent for individuals with a desire to reconcile, and associated with individual differences in the tendency to suppress thoughts. Together, these data suggest that individuals can lack meta-awareness that they have begun to think about a topic they are attempting to suppress, providing novel insight into the cognitive processes that are involved in attempting to control undesired mental states. (shrink)

In this paper, Knetsch's exchange paradigm is analyzed from the perspective of pragmatics and social norms. In this paradigm the participant, at the beginning of the experiment, receives an object from the experimenter and at the end, the same experimenter offers to exchange the received object for an equivalent object. The observed refusal to exchange is called the endowment effect. We argue that this effect comes from an implicature made by the participant about the experimenter's own expectations. The participant perceives (...) the received item as a gift, or as a present, from the experimenter that cannot be exchanged as stipulated by the social norms of western politeness common to both the experimenter and the participant. This implicature, however, should not be produced by participants from Kanak culture for whom the perceived gift of a good will be interpreted as a first act of exchange based on gift and counter-gift. This exchange is a natural, frequent, balanced, and indispensable act for all Kanak social bonds whether private or public. Kanak people also know the French social norms that they apply in their interactions with French people living in New Caledonia. In our experiment, we show that when the exchange paradigm takes place in a French context, with a French experimenter and in French, the Kanak participant is subject to the endowment effect in the same way as a French participant. On the other hand, when the paradigm is carried out in a Kanak context, with a Kanak experimenter and in the vernacular language, or in a Kanak context that approaches the ceremonial of the custom, the endowment effect is no longer observed. The same number of Kanak participants accept or refuse to exchange the endowed item. These results, in addition to providing a new explanation for the endowment effect, highlight the great flexibility of decisions according to social-cultural context. (shrink)

Both classical psychophysical work and recentfunctional imaging studies have suggested acritical role for the primary visual cortex(V1) in resolving the perceptual ambiguitiesexperienced during binocular rivalry. Here weexamine, by means of single-cell recordings andoptical imaging of intrinsic signals, thespatial characteristics of suppression elicitedby rival stimuli in cat V1. We find that the interocular suppression field of V1 neuronsis centred on the same position in space and isslightly larger (by a factor of 1.3) than theminimum response field, measured through thesame (...) eye. Suppression is always strongest at asingle position corresponding very closely tothe centre of the classical receptive field,and reduces responses through the other eye byup to 90% but typically around 40%. Thespatial pattern of interocular suppression, asrevealed by optical imaging, closely matchesthe cortical representation of the stimulus,which is being suppressed, both in terms of itsorientation and the eye of origin. Theseresults indicate that interocular suppressionis directly related to the functionalarchitecture of V1; it is probably caused bydirect inhibitory interactions betweenneighbouring cortical columns of oppositeocular dominance. (shrink)

I extend Ainslie's core claims with three cortico-striatal models that respectively subserve the key constructs of resolve, suppression, and routine habit. I show that these models suggest a more dynamical and symbiotic relation among the constructs: there are more ways they interact to reinforce willpower, and the temporal dimension of the interactions can often determine the effectiveness of the reinforcement.

The immediacy of daily encounters with gender roles, as well as the specific features of authoritarian mediation in their social shaping, make an analysis of gendered social interaction indispensable. In this paper the analysis is centered on the concept of social character, with special emphasis on authoritarianism as a continuous determinant of the transformation of natural sex into social construct of gender. It is precisely the authoritarian personality type that is the basis for alienated gender, dominated by sexism, a?natural? belonging (...) to the private or the public sphere of social life, suppression of individual human capacities, and reduction of choice. After a review of the theoretical conceptions of social character and authoritarianism, a historical-comparative analysis of authoritarianism is offered, where the latter is seen as an element of the social character within the perspective of the typology traditional - modern - postmodern society. It is argued in conclusion that, in spite of certain emancipatory achievements, men and women still tend to escape into the security of authoritarian alienation. Feminist theory remains a basic source for reflecting on these processes; therefore the author pleads for a wider acceptance of feminist insights as contributions to establishing a postmodern, interpretive?sociology in a new key?. Analiza drustvene interakcije medju polovima nametnuta je neposrednoscu svakodnevnog susretanja sa polnim ulogama, kao i specificnostima autoritarnog posredovanja u drustvenom uoblicavanju tih uloga. U ovom radu, analiza je organizovana oko pojma drustvenog karaktera, pri cemu se poseban naglasak stavlja na autoritarnost kao kontinuiranu determinantu preobrazaja prirodnog pola u drustveno konstruisanu kategoriju roda. Upravo je autoritarni tip licnosti podloga za otudjenu polnost, u kojoj dominiraju seksizam,?prirodno? pripadanje privatnoj ili javnoj sferi drustvenog zivota, suzbijanje individualnih ljudskih potencijala i suzavanje mogucnosti izbora. Posle pregleda teorijskih koncepcija drustvenog karaktera i pojma autoritarnosti, nudi se istorijsko-uporedna analiza prisustva autoritarnosti kao elementa drustvenog karaktera iz perspektive tipologije tradicionalno - moderno - postmoderno drustvo. Zakljucuje se da, i pored izvesnog ostvarenog emancipacijskog hoda, muskarci i zene jos uvek teze bekstvu u sigurnost autoritarne otudjenosti. Feministicka teorija ostaje nezaobilazna osnova za promisljanje ovih procesa, te se pledira za sire usvajanje feministickih uvida kao doprinosa oblikovanju jedne postmoderne, razumevajuce?sociologije u novome kljucu?. (shrink)

Cetaceans show high cognitive abilities and strong social bonds. Their primary sensory modality to communicate and sense the environment is acoustics. Research on their echolocation and social vocalizations typically uses visual and tactile systems adapted from research on primates or birds. Such research would benefit from a purely acoustic communication system to better match their natural capabilities. We argue that a full duplex system, in which signals can flow in both directions simultaneously is essential for communication research. We designed and (...) implemented a full duplex system to acoustically interact with cetaceans in the wild, featuring digital echo-suppression. We pilot tested the system in Arctic Norway and achieved an echo suppression of 18 dB. We discuss the limiting factors and how to improve the echo suppression further. The system enabled vocal interaction with the underwater acoustic scene by allowing experimenters to listen while producing sounds. We describe our motivations, then present our pilot deployment and give examples of initial explorative attempts to vocally interact with wild orcas and humpback whales. (shrink)

Previous research with speech and non-speech stimuli suggested that in audiovisual perception, visual information starting prior to the onset of corresponding sound can provide visual cues, and form a prediction about the upcoming auditory sound. This prediction leads to audiovisual interaction. Auditory and visual perception interact and induce suppression and speeding up of the early auditory event-related potentials such as N1 and P2. To investigate AV interaction, previous research examined N1 and P2 amplitudes and latencies in response to audio (...) only, video only, audiovisual, and control stimuli, and compared AV with auditory perception based on four AV interaction models. The current study addresses how different models of AV interaction express N1 and P2 suppression in music perception. Furthermore, the current study took one step further and examined whether previous musical experience, which can potentially lead to higher N1 and P2 amplitudes in auditory perception, influenced AV interaction in different models. Musicians and non-musicians were presented the recordings of a keyboard /C4/ key being played, as well as CO stimuli. Results showed that AV interaction models differ in their expression of N1 and P2 amplitude and latency suppression. The calculation of model and has consequences for the resulting N1 and P2 difference waves. Furthermore, while musicians, compared to non-musicians, showed higher N1 amplitude in auditory perception, suppression of amplitudes and latencies for N1 and P2 was similar for the two groups across the AV models. Collectively, these results suggest that when visual cues from finger and hand movements predict the upcoming sound in AV music perception, suppression of early ERPs is similar for musicians and non-musicians. Notably, the calculation differences across models do not lead to the same pattern of results for N1 and P2, demonstrating that the four models are not interchangeable and are not directly comparable. (shrink)

Of the many genes mutated on the road to tumor formation, few have received as much attention as p53. The gene has come to occupy center stage for the simple reason that it is more frequently altered in human tumors than any other known gene, undergoing mutation at a significant rate in almost every tumor type in which it has been studied. This association between p53 mutation and tumorigenesis has spurred a flurry of research attempting to delineate the normal function (...) of p53 and, by extension, the role of p53 mutation in tumor formation. At the cellular level, p53 has been shown to suppress growth. Recent efforts to further discern the function of p53 have centered on the underlying molecular basis for this growth suppression. In particular, research has focused on the identification of cellular molecules (specifically DNA and proteins) with which the p53 protein associates. p53 has now been shown to bind DNA in a sequence‐specific manner, and mounting evidence suggests that p53 acts as a transcription factor, perhaps regulating the expression levels of genes involved in the inhibition of cell growth. The logical next step in understanding p53 function involves the resolution of two questions: (1) what are the physiological transcriptional targets of p53, and (2) what cellular proteins regulate or mediate the ability of p53 to modulate transcription? Some initial clues to these puzzles are now emerging, and these form the subject of this review. (shrink)

As teams of people increasingly incorporate robot members, it is essential to consider how a robot's actions may influence the team's social dynamics and interactions. In this work, we investigated the effects of verbal support from a robot on human team members' interactions related to psychological safety and inclusion. We conducted a between-subjects experiment where the robot team member either gave verbal support or did not give verbal support to the human team members of a human-robot team comprised (...) of 2 human ingroup members, 1 human outgroup member, and 1 robot. We found that targeted support from the robot had a positive effect on outgroup members, who increased their verbal participation after receiving targeted support from the robot. When comparing groups that did and did not have verbal support from the robot, we found that outgroup members received fewer verbal backchannels from ingroup members if their group had robot verbal support. These results suggest that verbal support from a robot may have some direct benefits to outgroup members but may also reduce the obligation ingroup members feel to support the verbal contributions of outgroup members. (shrink)

This paper questions the conventional wisdom that physicians must suppress anger in response to patient misbehaviour. It distinguishes the emotion of anger from its expression, which leans toward concerned frustration and disappointment for the sake of professionalism in patient care. Drawing on the framework of person-centred health care as a virtue ethic, the paper first suggests four reasons why and when physician anger toward patient behaviour may occasionally be appropriate: the inevitability of sometimes feeling angry, anger as a cognitive and (...) behavioural resource, physician well-being, and potential patient benefit. The paper then proposes five conditions under which physician anger displays may be prudent as a measured response that balances emotional expression with professional conduct: ethical intention, rational justification, proportionality, problem-focused constructive expression, and precision. Potential benefits of this conceptualization of prudent anger include improved physician wellbeing, enhanced communication, and patient education to address perceived patient misbehaviour. The paper advocates for a cultural shift in health care environments to help allow for more authentic expression of physician frustration, aiming to harness prudent anger as a catalyst for positive change in patient-physician relationships and systemic improvements in health care delivery. (shrink)

Background: Short latency afferent inhibition provides a method to investigate mechanisms of sensorimotor integration. Cholinergic involvement in the SAI phenomena suggests that SAI may provide a marker of cognitive influence over implicit sensorimotor processes. Consistent with this hypothesis, we previously demonstrated that visual attention load suppresses SAI circuits preferentially recruited by anterior-to-posterior -, but not posterior-to-anterior -current induced by transcranial magnetic stimulation. However, cerebellar modulation can also modulate these same AP-sensitive SAI circuits. Yet, the consequences of concurrent cognitive and implicit (...) cerebellar influences over these AP circuits are unknown.Objective: We used cerebellar intermittent theta-burst stimulation to determine whether the cerebellar modulation of sensory to motor projections interacts with the attentional modulation of sensory to motor circuits probed by SAI.Methods: We assessed AP-SAI and PA-SAI during a concurrent visual detection task of varying attention load before and after cerebellar iTBS.Results: Before cerebellar iTBS, a higher visual attention load suppressed AP-SAI, but not PA-SAI, compared to a lower visual attention load. Post-cerebellar iTBS, the pattern of AP-SAI in response to visual attention load, was reversed; a higher visual attention load enhanced AP-SAI compared to a lower visual attention load. Cerebellar iTBS did not affect PA-SAI regardless of visual attention load.Conclusion: These findings suggest that attention and cerebellar networks converge on overlapping AP-sensitive circuitry to influence motor output by controlling the strength of the afferent projections to the motor cortex. This interaction has important implications for understanding the mechanisms of motor performance and learning. (shrink)

APPENDIX: The data emerging from the clinical and brain studies described above suggest that, in the case of OCD, there are two pertinent brain mechanisms that are distinguishable both in terms of neuro-dynamics and in terms of the conscious experiences that accompany them. These mechanisms can be characterized, on anatomical and perhaps evolutionary grounds, as a lower-level and a higher-level mechanism. The clinical treatment has, when successful, an activating effect on the higher-level mechanism, and a suppressive effect on the lower-level (...) one. (shrink)

NIK1 is a receptor‐like kinase involved in plant antiviral immunity. Although NIK1 is structurally similar to the plant immune factor BAK1, which is a key regulator in plant immunity to bacterial pathogens, the NIK1‐mediated defenses do not resemble BAK1 signaling cascades. The underlying mechanism for NIK1 antiviral immunity has recently been uncovered. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down‐regulate translational machinery genes, resulting in translation inhibition of host and viral (...) mRNAs and enhanced tolerance to begomovirus. Therefore, the NIK1 antiviral immunity response culminates in global translation suppression, which represents a new paradigm for plant antiviral defenses. Interestingly, transcriptomic analyses in nik1 mutant suggest that NIK1 may suppress antibacterial immune responses, indicating a possible opposite effect of NIK1 in bacterial and viral infections. (shrink)

Successful interactions between people are dependent on rapid recognition of social cues. We investigated whether head direction – a powerful social signal – is processed in the absence of conscious awareness. We used continuous flash interocular suppression to render stimuli invisible and compared the reaction time for face detection when faces were turned towards the viewer and turned slightly away. We found that faces turned towards the viewer break through suppression faster than faces that are turned away, (...) regardless of eye direction. Our results suggest that detection of a face with attention directed at the viewer occurs even in the absence of awareness of that face. While previous work has demonstrated that stimuli that signal threat are processed without awareness, our data suggest that the social relevance of a face, defined more broadly, is evaluated in the absence of awareness. (shrink)

Over the last decade, the efforts toward unraveling the complex interplay between the brain, body, and environment have set a promising line of research that utilizes neuroscience to study human performance in natural work contexts such as aviation. Thus, a relatively new discipline called neuroergonomics is holding the promise of studying the neural mechanisms underlying human performance in pursuit of both theoretical and practical insights. In this work, we utilized a neuroergonomic approach by combining insights from ecological psychology and embodied (...) cognition to study flight expertise. Specifically, we focused on the Mirror Neuron system as a key correlate for understanding the interaction between an individual and the environment, suggesting that it can be used to index changes in the coupling of perception-action associated with skill development. In this study, we measured the EEG mu suppression as a proxy of the Mirror Neuron system in experts (pilots) and novices while performing a distance estimation task in a landing scenario. To survey the specificity of this measure, we considered central, parietal and occipital electrode pools and analyzed alpha (8–13 Hz) and beta (18–25 Hz) rhythm bands. We hypothesized that in experts vs. novices, specific neural sensorimotor brain activity would underpin the connection between perception and action in an in-flight context. Preliminary results indicate that alpha and beta rhythm suppression was area-specific irrespective of groups, present in the central electrodes placed over the motor areas. Group analysis revealed that specifically alpha mu rhythm, but not beta, was significantly more suppressed in pilots vs. novices. Complementing these findings we found a trend in which the strength of mu suppression increased with the sense of presence experienced by the pilots. Such sensorimotor activation is in line with the idea that for a pilot, a distance judgment is intimately associated with the function of landing. This reflects the ability to use optical invariants to see the world in terms of the capabilities of the aircraft (e.g., reachability and glide angle). These preliminary findings support the role of embodied simulation mechanisms in visual perception and add important insights into a practical understanding of flight expertise, suggesting sensorimotor mechanisms as potential neuro-markers. (shrink)

The KCTD family includes tetramerization (T1) domain containing proteins with diverse biological effects. We identified a novel member of the KCTD family, BTBD10. A comprehensive analysis of protein‐protein interactions (PPIs) allowed us to put forth a number of testable hypotheses concerning the biological functions for individual KCTD proteins. In particular, we predict that KCTD20 participates in the AKT‐mTOR‐p70 S6k signaling cascade, KCTD5 plays a role in cytokinesis in a NEK6 and ch‐TOG‐dependent manner, KCTD10 regulates the RhoA/RhoB pathway. Developmental regulator (...) KCTD15 represses AP‐2α and contributes to energy homeostasis by suppressing early adipogenesis. TNFAIP1‐like KCTD proteins may participate in post‐replication DNA repair through PCNA ubiquitination. KCTD12 may suppress the proliferation of gastrointestinal cells through interference with GABAb signaling. KCTD9 deserves experimental attention as the only eukaryotic protein with a DNA‐like pentapeptide repeat domain. The value of manual curation of PPIs and analysis of existing high‐throughput data should not be underestimated. (shrink)

People use editorial criteria to decide whether to say or to suppress potential arguments. These criteria constitute people's standards as to what effective and appropriate arguments are like, and reflect general interaction goals. A series of empirical investigations has indicated that the standards fall into three classes: those having to do with argument effectiveness, those concerned with personal issues for arguer and target, and those centered on discourse quality. The essay also sketches the affinities certain types of people have for (...) the different criteria. (shrink)

Written with the suppression of the Tunisian students by their own government in view, Michel Foucault’s March 1968 ‘Linguistics and Social Sciences’ opens up a new horizon of historical inquiry and epitomises Foucault’s abiding interest in formulating new methods for studying the interaction of language and power. Translated into English for the first time by Jonathan D.S. Schroeder and Chantal Wright, this remarkable lecture constitutes Foucault’s most explicit and sustained statement of his project to revolutionise history by transposing the (...) analysis of logical relations into the history of knowledge. (shrink)

Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET) family, recognizes acetylated histones and is of importance in transcription, replication, and DNA repair. It also binds non‐histone proteins, DNA and RNA, contributing to development, tissue growth, and various physiological processes. Additionally, BRD4 has been implicated in driving diverse diseases, ranging from cancer, viral infection, inflammation to neurological disorders. Inhibiting its functions with BET inhibitors (BETis) suppresses the progression of several types of cancer, creating an impetus for translating these chemicals (...) to the clinic. The diverse roles of BRD4 are largely dependent on its interaction partners in different contexts. In this review we discuss the molecular mechanisms of BRD4 with its interacting partners in physiology and pathology. Current development of BETis is also summarized. Further understanding the functions of BRD4 and its partners will facilitate resolving the liabilities of present BETis and accelerate their clinical translation. (shrink)

The article examines the challenge of achieving sustainable mediational equilibrium within the Self–Other relationship. It argues that the mere pursuit of mutual understanding among dialogue participants is insufficient to guarantee productive communication, particularly in contexts where interactions are driven by competition for scarce resources and opportunities. Under such conditions, subjects risk becoming dependent on instrumental reason – the logic of control and suppression – which transforms both the Self and the Other from fully-fledged personalities into functions of reified (...) rationality. The analysis introduces a distinction between two roles of the individual: the person as a bearer of unique values and meanings, and the individual as a subject of social relations, an actor immersed in practical interactions. It is demonstrated that the capacity of the former to exert control over the latter is limited, and that interactions are shaped not only by the personal qualities of the participants but also by the impersonal logic of instrumental reason. This logic is conceptualized as a kind of third subjectivity that mediates the dialogue between the Self and the Other. Achieving mediational equilibrium becomes possible through the development of autonomy among the parties, through their transformation, mutual recognition, and the search for a measure of compatibility. This approach is traced through examples from A.S. Akhiezer’s theory of sociocultural mediation, A.P. Davydov’s concept of inter-subjective dialogue, and R. Bush and J. Folger’s theory of transformative mediation. Key concepts in the latter include empowerment (strengthening participants’ ability to clearly recognize their goals and make responsible decisions) and recognition (willingness to hear and understand the Other’s perspective). The essence of transformative mediation lies in the transition from imposing one party’s position to a collaborative search for new possibilities, allowing the realization of both Self and Other’s interests through dialogue. In conclusion, the article asserts the importance of overcoming the logic of mutual accusations by shifting the focus from the opponent’s personality to the impersonal structures limiting the self-determination of all parties. (shrink)

The ArgumentIn this paper, the perception of mathematics by a nonspecialist, the Romantic poet Friedrich von Hardenberg (Novalis), is investigated. The study is intended to contribute to a better understanding of the interactions between mathematics and the surrounding scientific culture in Germany at the turn of the nineteenth century. In regard to the problem how the cultural reception of a theory can influence its conceptual development, I argue that the reaction of nonspecialists can be imagined as a sort of (...) resonating body. Some aspects of a theory are stressed, others are ignored or even suppressed. In this way the value system of a theory and thereby the choice of problems and the style of argumentation can be influenced by groups of people who are not active scientists. In fact, the case at hand shows that a change of values has taken place. The original aim of the combinatorial school, whose mathematics Novalis studied, was the mechanization of symbolical calculations. But later, presumably under the influence of the general cultural climate in Germany, this same mathematics was interpreted as furthering — in modern words — a study of abstract structures. (shrink)

This article examines the popular journalistic discourses on the terroristic actions and ideological beliefs of Brenton Tarrant as a way to illuminate the problematic ways in which the notions of radicalization and extremism of rightism are framed. I argue that the journalistic discourses implicitly frame radicalization and extremism as isolated standalone phenomena in terms of their ideas and ideological proponents. This framing is problematic because it stimulates a practical solution of suppression and a moral reaction of condemnation that serve (...) to inadvertently fuel the growth of radicalization towards extremist attitudes and violence. Therefore, through my elaboration, I aim to lead the discussion towards a reframing of radicalization and extremism as not only standalone phenomena but also inherently interactive social processes. Such reframing carries important educational implications. I conclude that the educational role in the face of problematic discourses on radical rightism is to ensure that the classroom understands radicalization as a shared and interactive social process rather than as only an individual outcome. It is through such understanding that the educational approaches can then optimally resist radicalization and extremism through the acknowledgement of the social importance of inclusive dialogues. (shrink)

We describe here recent work on the molecular genetics of mitosis in the filamentous fungus Aspergillus nidulans. Aspergillus is one of three simple eukaryotes with powerful genetic systems that have been used to analyze mitosis. The modern molecular biological techniques available with this organism have made it possible to use mutations to identify genes and proteins that play an important role in mitosis. Three Aspergillus genes that affect mitosis are described. One gene, nimA, is specifically expressed late in the cell (...) cycle and codes for a putative protein kinase that induces mitosis, even in cells blocked in S‐phase. The second gene, bimG, codes for a putative phosphatase that interacts functionally with the nimA kinase. The third gene, bimE, codes for a protein that suppresses mitosis during interphase, apparently by keeping nimA turned off. None of these genes appear to be similar to any of the genes affecting mitosis that have been characterized in other eukaryotes, but rather appear to be elements of a system that prevents mitosis from occurring during interphase. (shrink)

Th is paper investigates the epistemic powers of democratic institutions through an assessment of three epistemic models of democracy : the Condorcet Jury Th eorem, the Diversity Trumps Ability Th eorem, and Dewey's experimentalist model. Dewey's model is superior to the others in its ability to model the epistemic functions of three constitutive features of democracy : the epistemic diversity of participants, the interaction of voting with discussion, and feedback mechanisms such as periodic elections and protests. It views democracy as (...) an institution for pooling widely distributed information about problems and policies of public interest by engaging the participation of epistemically diverse knowers. Democratic norms of free discourse, dissent, feedback, and accountability function to ensure collective, experimentallybased learning from the diverse experiences of diff erent knowers. I illustrate these points with a case study of community forestry groups in South Asia, whose epistemic powers have been hobbled by their suppression of women's participation. (shrink)

Philosophical interest in intentional action has flourished in recent decades. Typically, writers in the field of action theory seek necessary and sufficient conditions for a movement's being an action, conditions derived from a conceptual analysis of everyday action ascriptions. However, only a naturalistic account of intentional action, an account whose methods and aims are continuous with those of the empirical sciences, will truly help further our understanding of action as a biological phenomenon. ;Action is naturalized as a species of movement (...) that is both purposive and self-controlled, using these terms in novel senses. Various psychological and physiological models of purposiveness have been offered, including negative feedback, motor program, and dynamical systems models. However, while such non-historical models offer valuable insights into the nature of how organisms control their movements, they fail as general models of purposiveness because consideration of a movement's selectional history is required in order to classify movements as unitary behaviors rather than merely accidental motions. Non-historical models also fail to cover instances of unsuccessful purposive movements and cases of "functionally emergent behaviors." For such reasons, purposiveness must be seen as an historical property of movements; a movement is purposive insofar as it has a Millikanian proper function. ;An agent's capacity to exert a high degree of control over its movements marks the second key underlying property of action. I highlight an aspect of behavior-control which empirical theorists have largely ignored, namely the extent to which agents "could have done otherwise" than how they have in fact acted upon particular occasions. Self-control in this "could have done otherwise" sense is naturalized in terms of "modulatory interconnectivity." Modulatory interconnectivity involves the extent to which an agent's internal behavior-control modules facilitate behavioral interruptability via the interaction of informational links of inhibition and/or suppression. The greater the extent to which an agent's behavior-control modules have the capacity to modulate one another's activities, the more the agent has the capacity for self-control in the "could have done otherwise" sense. This view is elucidated and supported with the aid of models from robotics and neurophysiology. (shrink)

This article examined the recent emergence of the national and international issue of religious polarisation and identity, which affects some groups’ populism and fanaticism. Regarding social phenomena, religion and identity are intertwined like the two sides of a coin. This discourse has an impact how to interpret diversity on religious issues that are caused by political influences. Given the polarisation of identity politics and religion, the national and state campaign slogan ‘unity in diversity’ is merely wishful thinking. The polarisation of (...) identity and religion is heavily implicated in the Indonesia–Philippines border case; consequently, in some instances, the ‘seeds’ of these cases are discovered, eventually resulting in group fanaticism. This article employed the historical way of writing while also taking a social science angle that interacts with the research being done. For some communities, religion and identity may take on symbolic meaning, affecting how well they adapt and are accepted. However, the qualities of a community group or region are also shaped by historical events. According to the study’s findings, religion and ethnic identity have played important roles in long-standing historical processes and impacted them. This study is anticipated to ‘suppress’ the problem of political division involving religion and identity because the identification of ‘border’ communities depends not only on entity and identity issues but also on the community’s culture.Contribution: The contribution in this study is that it has an impact on religious issues and cultural identity relations perspectives. (shrink)

The philosophical substance of the senior thesis which the 21 years old John Rawls submitted to the Princeton Philosophy Department in 1942 consists in a religious ethics and its unfolding through communicatively mediated interaction. It already contains all the aspects essential for an egalitarian-universalistic deontology suitable for thematizing the absolute worth of the individual. The thesis shows that Rawls was not suppressing his religious socialization, but rather reworking it. We may now understand much better why Rawls was the first amongst (...) the great political philosophers to take seriously the pluralism of comprehensive doctrines and to initiate a fruitful debate on the status of religion in the public sphere. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.2 (2003) 444-449 [Access article in PDF] Psychoanalysis and Morality Eugene Goodheart Equals, by Adam Phillips; 246 pp. New York: Basic Books, 2002, $25.00. I THINK I WOULD RECOGNIZE an unattributed essay by Adam Phillips by its manner. Every serious writer aspires to such recognition. A comment on the book jacket of his latest collection of essays Equals tells us that his "territory is complication," though (...) "he reports back in the simplest of words." The words may be simple, but the movement of thought through the sentence, the paragraph and an entire essay is not. His way with complication, as I hope to show, is not always to Phillips's credit. The difficulty in reading him is in trying to know where he or she is being taken. The complication often leads to inconclusiveness, which is not a fault if the problem is insoluble or the situation genuinely intractable. Too often, however, the complication seems to reflect a love of it for its own sake. On other occasions, it degenerates into obscurantism.When Phillips does take a stand, he deliberately plants himself on shifting sands. As his title suggests, he is an egalitarian democrat, to which he brings the perspective of psychoanalysis. (He was Principal Child Psychotherapist at Charing Cross Hospital in London.) All hierarchy is anathema, all claims to superiority are to be resisted. Authority turns into authoritarianism. These are my sentences, uttered in an apodictic style, foreign to that of Phillips, but they reflect a view (his view) that the prose sometimes blurs. In its psychoanalytic application, the psychoanalyst is or should be unseated from his superior [End Page 444] position. Both the analyst and the analysand need to listen to what each has to say without passing (premature?) judgment, a model for all human interactions. (Phillips does not say whether the listener is permitted to distinguish sense from nonsense.) Conflict should be the rule, for where there is no conflict there is suppression. (But conflict on either side usually presupposes a desire to impose one's will on another. Is there a distinction to be made between fruitful and destructive conflict? Again Phillips has nothing to say on the subject.) As for the meaning of equality, he avoids all the real-life obstacles to genuine equality. He approves of Chantal Mouffe's version in which there can never be "an equality of wealth, or talent or beauty," but rather "an equality of rivenness, an equality of unknowingness, the equality of there being no foundations to master." I am not sure I understand what it means to be equal in rivenness. I believe that we are all unknowing in many ways, but not that we are equally unknowing. Is equality (in the presence?) of no foundations the same as equality in the prospect of death? In any event, I'm pretty sure that no authoritarian person or institution would be much troubled when faced with these banners of equality.Yet equality is a serious matter for Phillips, so serious that in another essay he is troubled by the threat that laughter presents. In a characteristically tortuous essay in which he tries conscientiously to sort out the benign and malign effects of mockery and ridicule, he ends by concluding that mockery is "the emotional terror of democracy" and "that what is always being ridiculed is our wish to be together, our secret affinity for each other." Always? Phillips of course knows the pleasures of ridicule, even its benignly toxic effect on our self-importance. But he begins from such an extreme position of its noxiousness (at the beginning of the essay he cites Primo Levi's initial response to the concentration camp as a joke: how could it possibly be what it purports to be?) that he cannot shake himself of the solemnity of his democratic conviction to allow a place for the human comedy. I wonder too at the authority of his claim for "our secret affinity for each other." The difficulty of democracy or togetherness for many or at least some may be precisely the secret aversion that they have for... (shrink)

Confucius is perhaps the most important philosopher in history. Today, his teachings shape the daily lives of more than 1.6 billion people. Throughout East Asia, Confucius’s influence can be seen in everything from business practices and family relationships to educational standards and government policies. Even as western ideas from Christianity to Communism have bombarded the region, Confucius’s doctrine has endured as the foundation of East Asian culture. It is impossible to understand East Asia, journalist Michael Schuman demonstrates, without first engaging (...) with Confucius and his vast legacy. Confucius created a worldview that is in many respects distinct from, and in conflict with, Western culture. As Schuman shows, the way that East Asian companies are managed, how family members interact with each other, and how governments see their role in society all differ from the norm in the West due to Confucius’s lasting impact. Confucius has been credited with giving East Asia an advantage in today’s world, by instilling its people with a devotion to learning, and propelling the region’s economic progress. Still, the sage has also been highly controversial. For the past 100 years, East Asians have questioned if the region can become truly modern while Confucius remains so entrenched in society. He has been criticized for causing the inequality of women, promoting authoritarian regimes, and suppressing human rights. Despite these debates, East Asians today are turning to Confucius to help them solve the ills of modern life more than they have in a century. As a wealthy and increasingly powerful Asia rises on the world stage, Confucius, too, will command a more prominent place in global culture. Touching on philosophy, history, and current affairs, Confucius tells the vivid, dramatic story of the enigmatic philosopher whose ideas remain at the heart of East Asian civilization. (shrink)

We challenge and extend Ainslie's top-down view of willpower as a dual function, resolve and suppression. Instead, we propose an alternative self-organizational view of the motivational system as a network of urges, incentives, drives, and so on that interact dynamically. With such a view, resolve, suppression, and other functions emerge under certain environmental and social conditions for certain personality profiles.

Mammalian telomeres have evolved safeguards to prevent their recognition as DNA double‐stranded breaks by suppressing the activation of various DNA sensing and repair proteins. We have shown that the telomere‐binding proteins TRF2 and RAP1 cooperate to prevent telomeres from undergoing aberrant homology‐directed recombination by mediating t‐loop protection. Our recent findings also suggest that mammalian telomere‐binding proteins interact with the nuclear envelope to maintain chromosome stability. RAP1 interacts with nuclear lamins through KU70/KU80, and disruption of RAP1 and TRF2 function result in (...) nuclear envelope rupture, promoting telomere‐telomere recombination to form structures termed ultrabright telomeres. In this review, we discuss the importance of the interactions between shelterin components and the nuclear envelope to maintain telomere homeostasis and genome stability. (shrink)

Major contributions emanating from Sagvolden et al.'s theory include elucidation of the role in attention-deficit/hyperactivity disorder (ADHD) of temporal information processing, social learning, and response extinction learning. Key issues include a need for clearer explanation of the relative role of impulsivity versus response suppression/inhibition in the dual process model, and delineation of genotype-environment correlations versus interactions in the social and experiential mechanisms posited.

From the perspective of free speech theory, both of the central First Amendment values - human autonomy and deliberative democracy - require robust protection for the places and spaces in which speech and public discourse occur. This Article argues that current Supreme Court doctrine does not effectively protect speech from content neutral regulation of place. The problem is that remaining neutral is consistent with policies that would dislocate the very place for the “marketplace of ideas.” Moreover, free speech theory focused (...) on autonomy and deliberative democracy has not adequately addressed the role that place plays in furthering these values. Speech may be, and increasingly in practice is, suppressed by control of the places and spaces where speech occurs. Limitations on public expressions critical of administration policies at Presidential events is a key example of the regulation of speech through the regulation of place. Dissent is increasingly displaced with the consequence that the figure of dissent risks disappearing from public discourse. Employing aspects of Hanna Arendt's political philosophy, this Article argues that we need to re-think and re-articulate the importance of public places for our free speech tradition. Personhood and human autonomy, as well as robust public debate, can only exist and develop in fullest form within social structures that provide public places and spaces for human interaction and discourse. Fundamentally, as Arendt suggests, we protect public appearances for public discourse not simply for its instrumental value for deliberation, but for the intrinsic value of creating persons and citizens in their fullest form. (shrink)

The essay refers to a concern for social justice in the origins of public health, borne in part by religious commitments, and to more recent expressions of a similar concern in debates about health equity. Equity, moreover, is affected by discursive power relations (dominant/hegemonic versus local/suppressed), which are discussed in relation to current research in the African Religious Health Assets Programme on the interaction of particular 'healthworlds' (a conceptual innovation) that shape the choices and behaviour of health-seekers. Two background theoretical (...) positions guide the argument: Amartya Sen's claim that development is linked to freedom (including religious freedom); and, building on Sen's and Martha Nussbaum's human capabilities theory, an asset-based community approach to the building or reconstruction of public health systems. On this basis, it is argued that health systems and health interventions are just to the extent that they mediate between the necessary leadership or polity from 'above' ( techné ) and the experience and wisdom ( métis ) of those who are 'below', taking into account the asymmetries of power that this equation represents. Because difference and diversity are so often expressed in what we might reasonably call 'religious' terms, I specifically emphasize the continuing persistence of religion and, hence, the importance of accounting for its pertinence in social theory generally, and in relation to discourses of health and justice in the African context specifically. Acknowledging the ambiguities of religion, I nevertheless argue that an appreciative alignment between public health systems and religious or faith-based initiatives in health promotion, prevention and care is crucial to sustainable and just health systems in Africa. (shrink)

I examine some common trends in ‘conflict management skills’, particularly those focused on practical results, and argue that they involve some moral problems, like the reliance on offensive stereotypes, the censorship of moral language, the promotion of distorted relationships, and sometimes the suppression of basic rights and obligations that constitute non–consequentialist moral constraints on human interactions (including dispute resolution). Since these approaches now appear in educational institutions, they are sending dangerous messages to those least able to critically assess (...) them, messages that denigrate the language, reflection, and interactions on which the moral life depends, thus undermining the possibility of moral education in the most fundamental sense of the phrase. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Nature of Proof in PsychiatryPaul Lieberman (bio)Keywordspsychotherapy process, knowledge and psychiatry, externalism, WittgensteinThis vivid clinical report illustrates recognizably, and provocatively, a number of routine, but often unexamined, clinical questions. In its few paragraphs, it depicts challenges that each practitioner confronts, and, in the flux of clinical work, addresses, however implicitly and imperfectly, every day: From what data, and by what processes, does a clinical formulation, or way of (...) understanding, come into being? How do we appraise its accuracy and adequacy? Of what value is even a well-substantiated understanding, in the mind of the therapist, to the patient? What is the power of empathy as a treatment tool? How do we assess someone's status as a “good candidate for therapy?” When, typically, only the outlines of a problem are visible, and its origins and implications are largely hidden, by what right do we recommend psychotherapy, and with what conception, at what level of detail, of what its outcome will be? These are among the questions that Dr. Bailey's story challenges us to address.They are clinical questions, of course, because they deal with empirical matters of fact—psychological processes, outcomes studies, and evidence. But they are also philosophical because, as Freud insisted and Dr. Bailey shows, information obtained in the clinical situation often has power and authority that lead us to believe we understand what is going on, understand the other person, even in the absence of scientifically tested hypotheses, or the clear application of research-based evidence. Interactions between people—including clinical interactions—have a life and ability to engage us. Their meanings can seem so transparent and convincing that no doubt or questioning may seem cogent. At their most powerful, such experiences can reawaken us to important realms of experience and feeling which we might, otherwise, forget, ignore, suppress, deny, or in other ways keep out of awareness; they have the potential to arouse us and reconnect us with truths that, once revived, can seem both valid and important—perhaps the kind of experience that we may derive from works of art or literature (in fact, Dr. Bailey's account could be seen as a clinical parable—meant to be neither true nor false, but instructive). But even less dramatic examples are commonplace: we do routinely claim to know and be able to interpret and understand the actions of other people from our everyday interactions with and observations of them.What is less clear is how to account for these convictions and how to appraise their value, because they do not derive from established scientific procedures. Clinical intuition has a role throughout medicine, but we usually expect it to be subjected later to more rigorous tests to establish the correct diagnosis. Yet, as Dr. Bailey's case illustrates, clinical intuition in the psychiatric encounter seems somehow different. When Colin [End Page 225] leads Dr. Bailey to the conclusion that a “painful lack of wounds” has made him depressed, we find this credible. It seems similarly credible that Dr. Bailey might be anxious about his own capacity to defend his young family, because he says he is, that he perceives Colin as testing his manhood or sincerity, because that seems to fit Colin's temperament, that being accurately understood is helpful, because most of us have had that experience and valued it, and that, most generally, an absence of challenge or of activity could be depressing. But suppose a patient believed that a painful lack of wounds produced diabetes instead of depression, or suppose he had developed epilepsy and attributed that to an absence of combat experience. We might see these as ‘pre-scientific’ or ‘hypothesis-generating’ (or worse). By contrast, it seems timid to consider psychiatric formulations to be always and only provisional or hypothetical.In what ways and to what extent should we expect psychiatry to be different, and why? Several considerations suggest that psychiatry's reasons are not, always and everywhere, the same as those of general medicine, nor are its objectives.In general medicine, we distinguish between signs and symptoms, on the one hand, and “underlying” disease processes, on the other. But in psychiatry, this distinction can be... (shrink)

While the coffee house as a space of political deliberation has been a common feature across the globe, there are few historical cases in which one can analyze the role of such face-to-face political deliberation under totalitarian moments in heretofore democratic states. Of the analogous cases of democratic reversal, India is one of the most important and under-researched. In 1975, then Prime Minister Indira Gandhi was convicted of corrupt election practices. Rather than concede to the high court ruling, she suspended (...) the constitution and installed herself as India’s sole political authority. The Indian Coffee House in New Delhi became the key site of resistance to the Emergency. The totalitarian moment pushed contentious politics into the Coffee House, initially galvanizing it: even the older members of Indira Gandhi's Congress Party, who were active participants in India's Freedom Movement, were key participants in coffee house deliberations. Eventually, however, Indian Coffee House was bulldozed and political deliberation crushed. The space of the coffee house may foster political deliberation among different viewpoints, but when interaction is concentrated in one such space, it becomes easier for the state and its agents to suppress oppositional politics and more difficult for both establishment and oppositional politics themselves to retain a diversified public sphere character. While coffee houses and analogous institutions are not adequate substitutes for other forms of democratic politics, therefore, they can encourage expression when other avenues are closed off and nourish the memory of a democratic political culture for the future. (shrink)

At extreme altitude (>5,000 – 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia is protective. Ketone bodies, synthesised during relative starvation, protect tissues such as the brain from reduced oxygen availability by mechanisms including the reduced generation of reactive oxygen species, improved mitochondrial (...) efficiency and activation of the ATP‐sensitive potassium (KATP) channel. Amino acids released from skeletal muscle also protect cells from hypoxia, and may interact synergistically with ketones to offer added protection. We thus propose that weight loss in hypoxia is an adaptive response: the amino acids and ketone bodies made available act not only as metabolic substrates, but as metabolic modulators, protecting cells from the hypoxic challenge.Also watch the Video Abstract. (shrink)

Social acceptance is assumed to have widespread positive effects on the recipient; however, ethnic/racial minorities often react negatively to social acceptance by White individuals. One possibility for such reactions might be their lack of trust in the genuineness of White individuals’ positive evaluations. Here, we examined the role that oxytocin—a neuropeptide putatively linked to social processes—plays in modulating reactions to acceptance or rejection during interracial interactions. Black participants received intranasal oxytocin or placebo and interacted with a White, same-sex stranger (...) who provided positive or negative social feedback. After positive feedback, participants given oxytocin tended to display approach-oriented cardiovascular responses of challenge, exhibited more cooperative behavior, and perceived the partner to have more favorable attitudes toward them after the interaction. Following negative feedback, oxytocin reduced anger suppression. Oxytocin did not modulate testosterone reactivity directly, but our exploratory analysis showed that the less participants suppressed anger during the interaction with their partner, the greater testosterone reactivity they displayed after the interaction. These results survived the correction for multiple testing with a false discovery rate of 20%, but not with a rate of 10 or 5%. Discussion centers on the interplay between oxytocin and social context in shaping interracial interactions. (shrink)

Interference phenomena are a well-known and crucial feature of quantum mechanics, the two-slit experiment providing a standard example. There are situations, however, in which interference effects are (artificially or spontaneously) suppressed. We shall need to make precise what this means, but the theory of decoherence is the study of (spontaneous) interactions between a system and its environment that lead to such suppression of interference. This study includes detailed modelling of system-environment interactions, derivation of equations (‘master equations’) for (...) the (reduced) state of the system, discussion of time-scales etc. A discussion of the concept of suppression of interference and a simplified survey of the theory is given in Section 2, emphasising features that will be relevant to the following discussion (and restricted to standard non-relativistic particle quantum mechanics.[1] A partially overlapping field is that of decoherent histories, which proceeds from an abstract definition of loss of interference, but which we shall not be considering in any detail. (shrink)