The motor modules during human walking are identified using non-negative matrix factorization from surface electromyography signals. The extraction of motor modules in healthy participants is affected by the change in pre-processing of EMG signals, such as low-pass filters ; however, the effect of different pre-processing methods, such as the number of necessary gait cycles in post-stroke patients with varying steps, remains unknown. We aimed to specify that the number of GCs influenced the motor modules extracted in the consideration (...) of LPFs in post-stroke patients. In total, 10 chronic post-stroke patients walked at a self-selected speed on an overground walkway, while EMG signals were recorded from the eight muscles of paretic lower limb. To verify the number of GCs, five GC conditions were set, namely, 25, 20, 15, 10, and 5 gate cycles with three LPFs. First, the number of modules, variability accounted for, and muscle weightings extracted by the NNMF algorithm were compared between the conditions. Next, a modified NNMF algorithm, in which the activation timing profiles among different GCs were unified, was performed to compare the muscle weightings more robustly between GCs. The number of motor modules was not significantly different, regardless of the GCs. The difference in VAF and muscle weightings in the different GCs decreased with the LPF of 4 Hz. Muscle weightings in 15 GCs or less were significantly different from those in 25 GCs using the modified NNMF. Therefore, we concluded that the variability extracted motor modules by different GCs was suppressed with lower LPFs; however, 20 GCs were needed for more representative extraction of motor modules during walking in post-stroke patients. (shrink)

This paper studies a family of monotonic extensions of first-order logic which we call modulated logics, constructed by extending classical logic through generalized quantifiers called modulated quantifiers. This approach offers a new regard to what we call flexible reasoning. A uniform treatment of modulated logics is given here, obtaining some general results in model theory. Besides reviewing the “Logic of Ultrafilters”, which formalizes inductive assertions of the kind “almost all”, two new monotonic logical systems are proposed here, the “Logic of (...) Many” and the “Logic of Plausibility”, that characterize assertions of the kind “many”, and “for a good number of”. Although the notion of simple majority (“more than half”) can be captured by means of a modulated quantifier semantically interpreted by cardinal measure on evidence sets, it is proven that this system, although sound, cannot be complete if checked against the intended model. This justifies the interest on a purely qualitative approach to this kind of quantification, what is guaranteed by interpreting the modulated quantifiers as notions of families of principal filters and reduced topologies, respectively. We prove that both systems are conservative extensions of classical logic that preserve important properties, such as soundness and completeness. Some additional perspectives connecting our approach to flexible reasoning through modulated logics to epistemology and social choice theory are also discussed. (shrink)

Hand function improvement in stroke survivors in the chronic stage usually plateaus by 6 months. Brain-computer interface (BCI)-guided robot-assisted training has been shown to be effective for facilitating upper-limb motor function recovery in chronic stroke. However, the underlying neuroplasticity change is not well understood. This study aimed to investigate the whole-brain neuroplasticity changes after 20-session BCI-guided robot hand training, and whether the changes could be maintained at the 6-month follow-up. Therefore, the clinical improvement and the neurological changes before, immediately after, (...) and 6 months after training were explored in 14 chronic stroke subjects. The upper-limb motor function was assessed by Action Research Arm Test (ARAT) and Fugl-Meyer Assessment for Upper-Limb (FMA), and the neurological changes were assessed using resting-state functional magnetic resonance imaging. Repeated-measure ANOVAs indicated that long-term motor improvement was found by both FMA (F[2,26]= 6.367,p= 0.006) and ARAT (F[2,26]= 7.230,p= 0.003). Seed-based functional connectivity analysis exhibited that significantly modulated FC was observed between ipsilesional motor regions (primary motor cortex and supplementary motor area) and contralesional areas (supplementary motor area, premotor cortex, and superior parietal lobule), and the effects were sustained after 6 months. The fALFF analysis showed that local neuronal activities significantly increased in central, frontal and parietal regions, and the effects were also sustained after 6 months. Consistent results in FC and fALFF analyses demonstrated the increase of neural activities in sensorimotor and fronto-parietal regions, which were highly involved in the BCI-guided training.Clinical Trial Registration:This study has been registered atClinicalTrials.govwith clinical trial registration number NCT02323061. (shrink)

In this paper, considering $L$-algebras, which include a significant number of other algebraic structures, we present a definition of modules on $L$-algebras ($L$-modules). Then we provide some examples and obtain some results on $L$-modules. Also, we present definitions of prime ideals of $L$-algebras and $L$-submodules (prime $L$-submodules) of $L$-modules, and investigate the relationship between them. Finally, by proving a number of theorems, we provide some conditions for having prime $L$-submodules.

One of the most important abilities we have as humans is the ability to think about number. In this chapter, we examine the question of whether there is an essential connection between language and number. We provide a careful examination of two prominent theories according to which concepts of the positive integers are dependent on language. The first of these claims that language creates the positive integers on the basis of an innate capacity to represent real numbers. The (...) second claims that language’s function is to integrate contents from modules that humans share with other animals. We argue that neither model is successful. (shrink)

Inception module is one of the most used variants in convolutional neural networks. It has a large portfolio of success cases in computer vision. In the past years, diverse inception flavours, differing in the number of branches, the size and the number of the kernels, have appeared in the scientific literature. They are proposed based on the expertise of the practitioners without any optimization process. In this work, an implementation of population-based incremental learning is proposed for automatic (...) optimization of the hyperparameters of the inception module. This hyperparameters optimization undertakes classification of the MNIST database of handwritten digit images. This problem is widely used as a benchmark in classification, and therefore, the learned best configurations for the Inception module will be of wide use in the deep learning community. In order to reduce the carbon footprint of the optimization process, policies for reducing the redundant evaluations have been undertaken. As a consequence of this work, an evaluation of configurations of the inception module and a mechanism for optimizing hyperparameters in deep learning architectures are stated. (shrink)

The underlying modules of existentially closed ▵-algebras are studied. Among other things, it is proved that they are all elementarily equivalent, and that all of them are existentially closed as modules if and only if ▵ is regular. It is also proved that every saturated module in the appropriate elementary equivalence class underlies an e.c. ▵-algebra. Applications to some problems in module theory are given. A number of open questions are mentioned.

Electrical brain activity modulation in terms of changes in its intensity and spatial distribution is a function of age and task demand. However, the dynamics of brain modulation is unknown when it depends on external factors such as training. The aim of this research is to verify the effect of deductive reasoning training on the modulation in the brain activity of healthy younger and older adults ( (mean age of 21 ± 3.39) and (mean age of 68.92 ± 5.72)). The (...) analysis reveals the benefits of training, showing that it lowers cerebral activation while increasing the number of correct responses in the trained reasoning task (). The brain source generators were identified by time-averaging low-resolution brain electromagnetic tomography (sLORETA) current density images. In both groups, a bilateral overactivation associated with the task and not with age was identified. However, while the profile of bilateral activation in younger adults was symmetrical in anterior areas, in the older ones, the profile was located asymmetrically in anterior and posterior areas. Consequently, bilaterality may be a marker of how the brain adapts to maintain cognitive function in demanding tasks in both age groups. However, the differential bilateral locations across age groups indicate that the tendency to brain modulation is determined by age. (shrink)

This paper puts forward a general framework for thought about human information processing. It is intended to avoid some of the problems of pipeline or stage models of function. At the same time it avoids the snare of supposing a welter of indefinitely many separate processes. The approach is not particularly original, but rather represents the common elements or presuppositions in a number of modern theories. These presuppositions are not usually explicit, however, and making them so reduces the danger (...) of slipping back into earlier modes of thought.The key point is to distinguish between persisting representations and the processes that translate one representation into another. Various classes or groups of persisting representations can be distinguished by the experimental treatments that interfere with them. In particular, there now seem to be several kinds of short-term or temporary storage, different from each other as well as from longterm memory; the translating processes also have several different modes or kinds. A particularly important aspect of the current position is that a model of this general type no longer requires some external agent to direct and control long sequences of behaviour. (shrink)

Afferent feedback can appreciably alter the pharyngeal phase of swallow. In order to measure the stability of the swallow motor pattern during several types of alterations in afferent feedback, we assessed swallow during a conventional water challenge in four anesthetized cats, and compared that to swallows induced by fixed (20 Hz) and stochastic (1-20Hz) electrical stimulation applied to the superior laryngeal nerve. The swallow motor patterns were evaluated by electromyographic activity (EMG) of eight muscles, based on their functional significance: laryngeal (...) elevators (mylohyoid, geniohyoid, and thyrohyoid); laryngeal adductor (thyroarytenoid); inferior pharyngeal constrictor (thyropharyngeus); upper esophageal sphincter (cricopharyngeus); and inspiratory activity (parasternal and costal diaphragm). Both the fixed and stochastic electrical stimulation paradigms increased activity of the laryngeal elevators, produced short-term facilitation evidenced by increasing swallow durations over the stimulus period, and conversely inhibited swallow-related diaphragm activity. Both the fixed and stochastic stimulus conditions also increased specific EMG amplitudes, which never occurred with the water challenges. Stochastic stimulation increased swallow excitability, as measured by an increase in the number of swallows produced. Consistent with our previous results, changes in the swallow motor pattern for pairs of muscles were only sometimes correlated with each other. We conclude that alterations in afferent feedback produced particular variations of the swallow motor pattern. We hypothesize that specific SLN feedback might modulate the swallow central pattern generator during aberrant feeding conditions (food/liquid entering the airway), which may protect the airway and serve as potentially important clinical diagnostic indicators. (shrink)

Humans have great locomotor adaptability to environmental demands, which has been investigated using a split-belt treadmill with belts on both the left and right sides. Thus far, neuromuscular control in split-belt locomotor adaptation has been evaluated by analyzing muscle activities at the individual muscle level. Meanwhile, in the motor control field, the muscle synergy concept has been proposed. Muscle synergies are considered the fundamental building blocks of movement and are groups of coactive muscles and time-varying activation patterns, thereby, reflecting the (...) neurophysiological characteristics of movement. To date, it remains unclear how such muscle synergies change during the adaptation and de-adaptation processes on the split-belt treadmill. Hence, we chronologically extracted muscle synergies while walking on the split-belt treadmill and examined changes in the number, muscle weightings, and temporal activation patterns of muscle synergies. Twelve healthy young males participated, and surface electromyography signals were recorded bilaterally from 13 lower-limb muscles. Muscle synergies were extracted by applying non-negative matrix factorization to the EMG data of each leg. We found that during split-belt walking, the number of synergies in the slow leg increased while an extra synergy appeared and disappeared in the fast leg. Additionally, the areas under the temporal activation patterns in several synergies in both legs decreased. When both belts returned to the same speed, a decrease in the number of synergies and an increase in the areas under the temporal activation patterns of several synergies were temporally shown in each leg. Subsequently, the number of synergies and the areas under the temporal activation patterns returned to those of normal walking before split-belt walking. Thus, changes in the number, muscle weightings, and temporal activation patterns of synergies were noted in the split-belt locomotor adaptation, suggesting that the adaptation and de-adaptation occurred at the muscle synergy level. (shrink)

The second messenger molecules cAMP and Ca2+ regulate a large number of eukaryotic cellular events. cAMP acts on protein kinases and Ca2+ works through a ubiquitous calcium‐binding protein, calmodulin. The two systems are not independent, however, but interact in several important fashions. These interactions, and, in particular, the modulation of the cAMP signal by two Ca2+/calmodulin‐regulated proteins, cyclic nucleotide phosphodiesterase and calcineurin, are described here.

Multicultural environments require learning multiple number notations wherein some are encountered more frequently than others. This leads to differences in exposure and consequently differences in usage between notations. We find that differential notational usage imposes a significant neurocognitive load on number processing. Despite simultaneous acquisition, forty-two adult binumerate populations, familiar with two positional writing systems namely Hindu Nagari digits and Hindu Arabic digits, reported significantly lower preference and usage for Nagari as compared to Arabic. Twenty-four participants showed significantly (...) increased reaction times and reduced accuracy while performing magnitude comparison tasks in Nagari with respect to Arabic. Functional magnetic resonance imaging revealed that processing Nagari elicited significantly greater activity in number processing and attention networks. A direct subtraction of networks for Nagari and Arabic notations revealed a neural circuit comprising of bilateral intra-parietal sulcus, inferior and mid frontal gyri, fusiform gyrus and the anterior cingulate cortex (FDR p<0.005). Additionally, whole brain correlation analysis showed that activity in the left inferior parietal region was modulated by task performance in Nagari. We attribute the increased activation in Ng to increased task difficulty due to infrequent exposure and usage. Our results reiterate the role of the left intra-parietal sulcus in modulating performance in numeric tasks and highlight that of the attention network for monitoring symbolic notation mode in binumerates. (shrink)

It is frequently claimed that the human mind is organized in a modular fashion, a hypothesis linked historically, though not inevitably, to the claim that many aspects of the human mind are innately specified. A specific instance of this line of thought is the proposal of an innately specified geometric module for human reorientation. From a massive modularity position, the reorientation module would be one of a large number that organized the mind. From the core knowledge position, (...) the reorientation module is one of five innate and encapsulated modules that can later be supplemented by use of human language. In this paper, we marshall five lines of evidence that cast doubt on the geometric module hypothesis, unfolded in a series of reasons: (1) Language does not play a necessary role in the integration of feature and geometric cues, although it can be helpful. (2) A model of reorientation requires flexibility to explain variable phenomena. (3) Experience matters over short and long periods. (4) Features are used for true reorientation. (5) The nature of geometric information is not as yet clearly specified. In the final section, we review recent theoretical approaches to the known reorientation phenomena. (shrink)

Neurological diseases (NDs), featured by progressive dysfunctions of the nervous system, have become a growing burden for the aging populations. N‐Deacetylase and N‐sulfotransferase 3 (NDST3) is known to catalyze deacetylation and N‐sulfation on disaccharide substrates. Recently, NDST3 is identified as a novel deacetylase for tubulin, and its newly recognized role in modulating microtubule acetylation and lysosomal acidification provides fresh insights into ND therapeutic approaches using NDST3 as a target. Microtubule acetylation and lysosomal acidification have been reported to be critical for (...) activities in neurons, implying that the regulators of these two biological processes, such as the previously known microtubule deacetylases, histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2), could play important roles in various NDs. Aberrant NDST3 expression or tubulin acetylation has been observed in an increasing number of NDs, including amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), schizophrenia and bipolar disorder, Alzheimer's disease (AD), and Parkinson's disease (PD), suggesting that NDST3 is a key player in the pathogenesis of NDs and may serve as a target for development of new treatment of NDs. (shrink)

Merging the information from different senses is essential for successful interaction with real-life situations. Indeed, sensory integration can reduce perceptual ambiguity, speed reactions, or change the qualitative sensory experience. It is widely held that integration occurs at later processing stages and mostly in higher association cortices; however, recent studies suggest that sensory convergence can occur in primary sensory cortex. A good model for early convergence proved to be the auditory cortex, which can be modulated by visual and tactile stimulation; however, (...) given the large number and small size of auditory fields, neither human imaging nor microelectrode recordings have systematically identified which fields are susceptible to multisensory influences. To reconcile findings from human imaging with anatomical knowledge from nonhuman primates, we exploited high-resolution imaging (functional magnetic resonance imaging) of the macaque monkey to study the modulation of auditory processing by visual stimulation. Using a functional parcellation of auditory cortex, we localized modulations to individual fields. Our results demonstrate that both primary (core) and nonprimary (belt) auditory fields can be activated by the mere presentation of visual scenes. Audiovisual convergence was restricted to caudal fields [prominently the core field (primary auditory cortex) and belt fields (caudomedial field, caudolateral field, and mediomedial field)] and continued in the auditory parabelt and the superior temporal sulcus. The same fields exhibited enhancement of auditory activation by visual stimulation and showed stronger enhancement for less effective stimuli, two characteristics of sensory integration. Together, these findings reveal multisensory modulation of auditory processing prominently in caudal fields but also at the lowest stages of auditory cortical processing. (shrink)

Haptic object recognition is usually an efficient process although slower and less accurate than its visual counterpart. The early loss of vision imposes a greater reliance on haptic perception for recognition compared to the sighted. Therefore, we may expect that congenitally blind persons could recognize objects through touch more quickly and accurately than late blind or sighted people. However, the literature provided mixed results. Furthermore, most of the studies on haptic object recognition focused on performance, devoting little attention to the (...) exploration procedures that conducted to that performance. In this study, we used iCube, an instrumented cube recording its orientation in space as well as the location of the points of contact on its faces. Three groups of congenitally blind, late blind and age and gender-matched blindfolded sighted participants were asked to explore the cube faces where little pins were positioned in varying number. Participants were required to explore the cube twice, reporting whether the cube was the same or it differed in pins disposition. Results showed that recognition accuracy was not modulated by the level of visual ability. However, congenitally blind touched more cells simultaneously while exploring the faces and changed more the pattern of touched cells from one recording sample to the next than late blind and sighted. Furthermore, the number of simultaneously touched cells negatively correlated with exploration duration. These findings indicate that early blindness shapes haptic exploration of objects that can be held in hands. (shrink)

A number of proteins homologous to recoverin have been identified in the brains of the several vertebrate species. The brainderived members originally contain four EF-hand domains, but NH2- terminal domain is aberrant. Many of these proteins inhibited light-induced rhodopsin phosphorylation at high [Ca2+], suggesting that the brain-derived members may act as a Ca2+-sensitive modulator of receptor phosphorylation, as recoverin does.

We present a computational model of multiple-object tracking that makes trial-level predictions about the allocation of visual attention and the effect of this allocation on observers' ability to track multiple objects simultaneously. This model follows the intuition that increased attention to a location increases the spatial resolution of its internal representation. Using a combination of empirical and computational experiments, we demonstrate the existence of a tight coupling between cognitive and perceptual resources in this task: Low-level tracking of objects generates bottom-up (...) predictions of error likelihood, and high-level attention allocation selectively reduces error probabilities in attended locations while increasing it at non-attended locations. Whereas earlier models of multiple-object tracking have predicted the big picture relationship between stimulus complexity and response accuracy, our approach makes accurate predictions of both the macro-scale effect of target number and velocity on tracking difficulty and micro-scale variations in difficulty across individual trials and targets arising from the idiosyncratic within-trial interactions of targets and distractors. (shrink)

We define a first-order extension LK(CP) of the cutting planes proof system CP as the first-order sequent calculus LK whose atomic formulas are CP-inequalities ∑ i a i · x i ≥ b (x i 's variables, a i 's and b constants). We prove an interpolation theorem for LK(CP) yielding as a corollary a conditional lower bound for LK(CP)-proofs. For a subsystem R(CP) of LK(CP), essentially resolution working with clauses formed by CP- inequalities, we prove a monotone interpolation theorem (...) obtaining thus an unconditional lower bound (depending on the maximum size of coefficients in proofs and on the maximum number of CP-inequalities in clauses). We also give an interpolation theorem for polynomial calculus working with sparse polynomials. The proof relies on a universal interpolation theorem for semantic derivations [16, Theorem 5.1]. LK(CP) can be viewed as a two-sorted first-order theory of Z considered itself as a discretely ordered Z-module. One sort of variables are module elements, another sort are scalars. The quantification is allowed only over the former sort. We shall give a construction of a theory LK(M) for any discretely ordered module M (e.g., LK(Z) extends LK(CP)). The interpolation theorem generalizes to these theories obtained from discretely ordered Z-modules. We shall also discuss a connection to quantifier elimination for such theories. We formulate a communication complexity problem whose (suitable) solution would allow to improve the monotone interpolation theorem and the lower bound for R(CP). (shrink)

Carruthers invokes a number of controversial assumptions to support his thesis. Most are questionable and unnecessary to investigate the wider relevance of language in cognition. A number of research programs (e.g., interactionist psycholinguistics and cognitive linguistics) have for years pursued a similar thesis and provide a more empirically grounded framework for investigating language’ cognitive functions.

In the processing of subject-verb agreement, non-subject plural nouns following a singular subject sometimes “attract” the agreement with the verb, despite not being grammatically licensed to do so. This phenomenon generates agreement errors in production and an increased tendency to fail to notice such errors in comprehension, thereby providing a window into the representation of grammatical number in working memory during sentence processing. Research in this topic, however, is primarily done in related languages with similar agreement systems. In order (...) to increase the cross-linguistic coverage of the processing of agreement, we conducted a self-paced reading study in Modern Standard Arabic. We report robust agreement attraction errors in relative clauses, a configuration not particularly conducive to the generation of such errors for all possible lexicalizations. In particular, we examined the speed with which readers retrieve a subject controller for both grammatical and ungrammatical agreeing verbs in sentences where verbs are preceded by two NPs, one of which is a local non-subject NP that can act as a distractor for the successful resolution of subject-verb agreement. Our results suggest that the frequency of errors is modulated by the kind of plural formation strategy used on the attractor noun: nouns which form plurals by suffixation condition high rates of attraction, whereas nouns which form their plurals by internal vowel change (ablaut) generate lower rates of errors and reading-time attraction effects of smaller magnitudes. Furthermore, we show some evidence that these agreement attraction effects are mostly contained in the right tail of reaction time distributions. We also present modeling data in the ACT-R framework which supports a view of these ablauting patterns wherein they are differentially specified for number and evaluate the consequences of possible representations for theories of grammar and parsing. (shrink)

Evolving as Foucault’s third modulation of power, security power marks a radical departure from previous eras of sovereign and disciplinary power. Dramatically decentering the individual, altering the means by which government acts and shifting from a static to a dynamic conception of temporal activity, an understanding of Foucauldian security power provides a number of critical insights into modern governance. This paper seeks to explain and analyze Foucault’s conceptualization of security power as the new language of governance and apply it (...) in relation to the pervasive phenomena of government attempts to control fertility. Using the cases of inter-war France and post-colonial India, the theorization of security power will be grounded in the realities of natalist policy demonstrating the universality of the exercise of security power and its applicability to numerous contexts and settings. The concretization of theory in case study not only illuminates the workings of a new model of power but highlights the difficulty of resisting this novel type of government control. Understanding power to understand modes of resistance is central to the Foucauldian method, and drawing from Foucault’s newly translated lectures, this paper will bring to light a fascinating mode of analysis which helps illuminate the evolving nature of power and control in the modern era. (shrink)

Theories of number concepts often suppose that the natural numbers are acquired as children learn to count and as they draw an induction based on their interpretation of the first few count words. In a bold critique of this general approach, Rips, Asmuth, Bloomfield [Rips, L., Asmuth, J. & Bloomfield, A.. Giving the boot to the bootstrap: How not to learn the natural numbers. Cognition, 101, B51–B60.] argue that such an inductive inference is consistent with a representational system that (...) clearly does not express the natural numbers and that possession of the natural numbers requires further principles that make the inductive inference superfluous. We argue that their critique is unsuccessful. Provided that children have access to a suitable initial system of representation, the sort of inductive inference that Rips et al. call into question can in fact facilitate the acquisition of larger integer concepts without the addition of any further principles. (shrink)

Although the rapid growth of digital data and computationally advanced methods in the social sciences has in many ways exacerbated tensions between the so-called ‘quantitative’ and ‘qualitative’ approaches, it has also been provocatively argued that the ubiquity of digital data, particularly online data, finally allows for the reconciliation of these two opposing research traditions. Indeed, a growing number of ‘qualitatively’ inclined researchers are beginning to use computational techniques in more critical, reflexive and hermeneutic ways. However, many of these claims (...) for ‘quali-quantitative’ methods hinge on a single technique: the network graph. Networks are relational, allow for the questioning of rigid categories and zooming from individual cases to patterns at the aggregate. While not refuting the use of networks in these studies, this paper argues that there must be other ways of doing quali-quantitative methods. We first consider a phenomenon which falls between quantitative and qualitative traditions but remains elusive to network graphs: the spread of information on Twitter. Through a case study of debates about nuclear power on Twitter, we develop a novel data visualisation called the modulation sequencer which depicts the spread of URLs over time and retains many of the key features of networks identified above. Finally, we reflect on the role of such tools for the project of quali-quantitative methods. (shrink)

Human perception responds primarily to sound character rather than sound level. Wind farms are unique sound sources and exhibit special audible and inaudible characteristics that can be described as modulating sound or as a tonal complex. Wind farm compliance measures based on a specified noise number alone will fail to address problems with noise nuisance. The character of wind farm sound, noise emissions from wind farms, noise prediction at residences, and systemic failures in assessment processes are examined. Human perception (...) of wind farm sound is compared with noise assessment measures and complaint histories. The adverse effects on health of persons susceptible to noise from wind farms are examined and a hypothesis, the concept of heightened noise zones (pressure variations), as a marker for cause and effect is advanced. A sound level of LAeq 32 dB outside a residence and above an individual’s threshold of hearing inside the home are identified as markers for serious adverse health effects affecting susceptible individuals. The article is referenced to the author’s research, measurements, and observations at different wind farms in New Zealand and Victoria, Australia. (shrink)

This study investigates the ability of individuals with psychopathy to perform passive avoidance learning and whether this ability is modulated by level of reinforcement/punishment. Nineteen psychopathic and 21 comparison individuals, as defined by the Hare Psychopathy Checklist Revised (Hare, 1991), were given a passive avoidance task with a graded reinforcement schedule. Response to each rewarding number gained a point reward specific to that number (i.e., 1, 700, 1400 or 2000 points). Response to each punishing number lost a (...) point punishment specific to that number (i.e., the loss of 1, 700, 1400 or 2000 points). In line with predictions, individuals with psychopathy made more passive avoidance errors than the comparison individuals. In addition, while the performance of both groups was modulated by level of reward, only the performance of the comparison population was modulated by level of punishment. The results are interpreted with reference to a computational account of the emotional learning impairment in individuals with psychopathy. (shrink)

With the continuous development of software, it is inevitable that there will be various unpredictable problems in computer software or programs that will damage the normal operation of the software. In the paper, static analysis software is taken as the research object, the errors or failures caused by the potential defects of the software modules are analyzed, and a software analysis method based on big data tendency prediction is proposed to use the software defects of the stacked noise reduction sparse (...) analyzer to predict. This method can learn features from original defect data, directly and efficiently extract required features of all levels from software defect data by setting different number of hidden layers, sparse regularization parameters, and noise ratio, and then classify and predict the extracted features by combining with big data. Through experimental tests, the performance of the presented method is better than that of the comparison method in correct rate, accuracy rate, recall rate, F1-measurement, AUC value, and running time, which proves that the research results in this paper have more accurate failure prediction effect and can timely eliminate software failures. (shrink)

We investigate the issues of Diophantine definability over the non-finitely generated version of non-degenerate modules contained in the infinite algebraic extensions of the rational numbers. In particular, we show the following. Let k be a number field and let K inf be a normal algebraic, possibly infinite, extension of k such that k has a normal extension L linearly disjoint from K inf over k. Assume L is totally real and K inf is totally complex. Let M inf be (...) a non-degenerate O k -module, possibly non-finitely generated and contained in O Kinf . Then M inf contains a submodule M¯ inf such that M inf /M¯ inf is torsion and O k has a Diophantine definition over M¯ inf. (shrink)

The National Medical Commission of India introduced the Competency Based Curriculum in Medical Education for undergraduate medical students in 2019 with a new module named Attitude, Ethics and Communication (AETCOM) across the country. There was a consensus for teaching medical ethics in an integrated way, suggesting dedicated hours in each phase of undergraduate training. The AETCOM module was prepared and circulated as a guide to acquire necessary competency in attitudinal, ethical and communication domains. This study was aimed to (...) explore the perceptions of students and medical teachers and identify the challenges in teaching and learning process of the newly implemented AETCOM module. It was a mixed method designed study with structured questionnaires for students and teachers at various medical schools in India. Based on the quantitative data, in-depth interviews with medical teachers were undertaken. Challenges were perceived by both students and teachers. The students had a mixed perception, facing difficulties in passive learning with scarce resource materials. Challenges identified by teachers were a lack of knowledge and skills required for teaching bioethics, the logistics of managing large numbers of students in the stipulated time frame, interdisciplinary integration—both horizontal and vertical, and assessment program in terms competency-based education. The study draws the attention of all stakeholders for a revision and efforts for further improvement in the teaching and assessment process, and setting a standard model in medical education in India. (shrink)

A substantial portion of the human genome has been found to consist of simple sequence repeats, including microsatellites and minisatellites. Microsatellites, tandem repeats of 1–6 nucleotides, form the template for dynamic mutations, which involve heritable changes in the lengths of repeat sequences. In recent years, a large number of human disorders have been found to be caused by dynamic mutations, the most common of which are trinucleotide repeat expansion diseases. Dynamic mutations are common to numerous nervous system disorders, including (...) Huntington's disease, various spinocerebellar ataxias, fragile X syndrome, fragile X tremor/ataxia syndrome, Friedreich ataxia and other neurodegenerative disorders. The involvement of dynamic mutations in brain disorders will be reviewed, with a focus on the large group caused by CAG/glutamine repeat expansions. We will also outline a proposed role of tandem repeat polymorphisms (TRPs), with unique ‘digital’ genetic distributions, in modulating brain development and normal function, so as to generate additional mutational diversity upon which natural selection may act. BioEssays 29:525–535, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Understanding spoken words involves a rapid mapping from speech to conceptual representations. One distributed feature-based conceptual account assumes that the statistical characteristics of concepts’ features—the number of concepts they occur in and likelihood of co-occurrence —determine conceptual activation. To test these claims, we investigated the role of distinctiveness/sharedness and correlational strength in speech-to-meaning mapping, using a lexical decision task and computational simulations. Responses were faster for concepts with higher sharedness, suggesting that shared features are facilitatory in tasks like lexical (...) decision that require access to them. Correlational strength facilitated responses for slower participants, suggesting a time-sensitive co-occurrence-driven settling mechanism. The computational simulation showed similar effects, with early effects of shared features and later effects of correlational strength. These results support a general-to-specific account of conceptual processing, whereby early activation of shared features is followed by the gradual emergence of a specific target representation. (shrink)

Divergent evolution can explain how many proteins containing structurally similar domains, which perform a variety of related functions, have evolved from a relatively small number of modules or protein domains. However, it cannot explain how protein domains with similar, but distinguishable, functions and similar, but distinguishable, structures have evolved. Examples of this are the RNA‐binding proteins containing the RNA‐binding domain (RBD), and a newly established protein group, the cold‐shock domain (CSD) protein family. Both protein domains contain conserved RNP motifs (...) on similar single‐stranded nucleic acid‐binding surfaces. Apart from the RNP motifs, which have a similar function, the two families show little similarity in topology or amino acid sequence. This can be considered an interesting example of convergent evolution at the molecular level. Previously, a β‐sheet surface was found to interact with RNA in non‐homologous proteins from yeast, phage and man, revealing that this mode of RNA binding may be a widely recurring theme. (shrink)

The present study uses event-related potentials to examine subject–verb person agreement in Spanish, with a focus on how markedness with respect to the speech participant status of the subject modulates processing. Morphological theory proposes a markedness distinction between first and second person, on the one hand, and third person on the other. The claim is that both the first and second persons are participants in the speech act, since they play the speaker and addressee roles, respectively. In contrast, third person (...) refers to whomever is neither the speaker nor the addressee (i.e., it is unmarked for person). We manipulated speech participant by probing person agreement with both first-person singular subjects (e.g., yo…lloro “I…cry- 1ST PERSON-SG ”) and third-person singular ones (e.g., la viuda…llora “the widow…cry- 3RD PERSON-SG ”). We also manipulated agreement by crossing first-person singular subjects with third-person singular verbs (e.g., yo… ∗ llora “I…cry- 3RD PERSON-SG ”) and vice versa (e.g., la viuda… ∗ lloro “the widow…cry- 1ST PERSON-SG ”). Results from 28 native speakers of Spanish revealed robust positivities for both types of person violations, relative to their grammatical counterparts between 500 and 1000 ms, an effect that shows a central-posterior distribution, with a right hemisphere bias. This positivity is consistent with the P600, a component associated with a number of morphosyntactic operations (and reanalysis processes more generally). No negativities emerged before the P600 (between 250 and 450 ms), although both error types yielded an anterior negativity in the P600 time window, an effect that has been argued to reflect the memory costs associated with keeping the errors in working memory to provide a sentence-final judgment. Crucially, person violations with a marked subject (e.g., yo… ∗ llora “I…cry- 3RD PERSON-SG ”) yielded a larger P600 than the opposite error type between 700 and 900 ms. This effect is consistent with the possibility that, upon encountering a subject with marked features, feature activation allows the parser to generate a stronger prediction regarding the upcoming verb. The larger P600 for person violations with a marked subject might index the reanalysis process that the parser initiates when there is a conflict between a highly expected verbal form (i.e., more so than in the conditions with an unmarked subject) and the form that is actually encountered. (shrink)

This chapter defends the positive thesis which constitutes its title. It argues first, that the mind has been shaped by natural selection; and second, that the result of that shaping process is a modular mental architecture. The arguments presented are all broadly empirical in character, drawing on evidence provided by biologists, neuroscientists and psychologists (evolutionary, cognitive, and developmental), as well as by researchers in artificial intelligence. Yet the conclusion is at odds with the manifest image of ourselves provided both by (...) introspection and by common-sense psychology. The chapter concludes by sketching how a modular architecture might be developed to account for the patently unconstrained character of human thought, which has served as an assumption in a number of recent philosophical attacks on mental modularity. (shrink)

Erratum to: What Happens in the Lab Does Not Stay in the Lab: Applying Midstream Modulation to Enhance Critical Reflection in the Laboratory Content Type Journal Article Category Erratum Pages 789-789 DOI 10.1007/s11948-011-9334-7 Authors Daan Schuurbiers, Centre for Society and Genomics, Radboud University Nijmegen, Nijmegen, The Netherlands Journal Science and Engineering Ethics Online ISSN 1471-5546 Print ISSN 1353-3452 Journal Volume Volume 17 Journal Issue Volume 17, Number 4.

Dysfunction or injury of pain-transmitting primary afferents' central pathways can result in pain. The organism as a whole responds to such injury and consequently many symptoms of neuropathic pain develop. The nervous system responds to painful events and injury with neuroplasticity. Both peripheral sensitization and central sensitization take place and are mediated by a number of biochemical factors, including genes and receptors. Correction of altered receptors activity is the logical way to intervene therapeutically. [berkley; blumberg et al.; coderre & (...) katz; dickenson; mcmahon; wiesenfeld-hallin et al.]. (shrink)

Recent findings indicate that the constituting digits of multi-digit numbers are processed, decomposed into units, tens, and so on, rather than integrated into one entity. This is suggested by interfering effects of unit digit processing on two-digit number comparison. In the present study, we extended the computational model for two-digit number magnitude comparison of Moeller, Huber, Nuerk, and Willmes (2011a) to the case of three-digit number comparison (e.g., 371_826). In a second step, we evaluated how hundred-decade and (...) hundred-unit compatibility effects were moderated by varying the percentage of within-hundred (e.g., 539_582) and within-hundred-and-decade filler items (e.g., 483_489). From the results we predict that numerical distance as well as compatibility effects should indeed be modulated by the relevance of tens and units in three-digit number magnitude comparison: While in particular the hundred distance effect should decrease, we predict hundred-decade and hundred-unit compatibility effects to increase with the relevance of tens and units. (shrink)

Are small and large numbers represented similarly or differently on the mental number line? The size effect was used to argue that numbers are represented differently. However, recently it has been argued that the size effect is due to the comparison task and is not derived from the mental number line per se. Namely, it is due to the way that the mental number line is mapped onto the task-relevant output component. Here synesthesia was used to disentangle (...) these two alternatives. In two naming experiments a digit-color synesthete showed that the congruity effect was modulated by number size. These results support the existence of a mental number line with a vaguer numerical representation as numbers increase in size. In addition, the results show that in digit-color synesthesia, colors can evoke numerical representation automatically. (shrink)

First language attrition in adulthood offers new insight on neuroplasticity and the role of language experience in shaping neurocognitive responses to language. Attriters are multilinguals for whom advancing L2 proficiency comes at the cost of the L1, as they experience a shift in exposure and dominance. To date, the neurocognitive mechanisms underlying L1 attrition are largely unexplored. Using event-related potentials, we examined L1-Italian grammatical processing in 24 attriters and 30 Italian native-controls. We assessed whether attriters differed from non-attriting native speakers (...) in their online detection and re-analysis/repair of number agreement violations, and whether differences in processing were modulated by L1-proficiency. To test both local and non-local agreement violations, we manipulated agreement between three inflected constituents and examined ERP responses on two of these. Our findings revealed group differences in amplitude, scalp distribution, and duration of LAN/N400 + P600 effects. We discuss these differences as reflecting influence of attriters’ L2-English, as well as shallower online sentence repair processes than in non-attriting native speakers. ERP responses were also predicted by L1-Italian proficiency scores, with smaller N400/P600 amplitudes in lower proficiency individuals. Proficiency only modulated P600 amplitude between 650 and 900 ms, whereas the late P600 depended on group membership and amount of L1 exposure within attriters. Our study is the first to show qualitative and quantitative differences in ERP responses in attriters compared to non-attriting native speakers. Our results also emphasize that proficiency predicts language processing profiles, even in native-speakers, and that the P600 should not be considered a monolithic component. (shrink)

The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...) the number of cell functions they can actually control, both GPCRs and their associated signal transduction pathways are extremely well conserved, for only a few alleles with null or minor functional alterations have so far been found. This would seem to suggest that, beside a mechanism for DNA repairing, there must be another level of quality control that may help maintaining GPCRs rather stable throughout evolution. We propose here receptor oligomerization to be a basic molecular mechanism controlling GPCRs redundancy in many different cell types, and the plasma membrane as the first hierarchical cell structure at which selective categorical sensing may occur. Categorical sensing can be seen as the cellular capacity for identifying and ordering complex patterns of mixed signals out of a contextual matrix, i.e., the recognition of meaningful patterns out of ubiquitous signals. In this context, redundancy and degeneracy may appear as the required feature to integrate the cell system into functional units of progressively higher hierarchical levels. (shrink)

How may feelings of love and hate impact people’s attention? We used a modified Attentional Blink (AB) task in which 300 participants were asked to categorise a name representing a person towards whom they felt either hate, love, or neutral (first target) plus identify a number word (second target), both embedded in a rapidly presented stream of other words. The lag to the second target was systematically varied. Contrary to our hypothesis, results revealed that both hated and loved names (...) resulted in higher accuracy for the second target than neutral names, which was largely independent of lag. Also, there we observed no sustained transfer effects of love and hate onto neutral name trials. The findings differ from prior research on attentional blink and transient, non-personal, stimulus-driven emotions, suggesting that interpersonal feelings activate different attention-relevant mechanisms. Relevant to future research, we speculate that love and hate are motivators of goal-directed behaviour that facilitate subsequent information processing. (shrink)

Whether negative numbers have a fixed spatial–numerical association of response codes effect, and whether the spatial representation of negative numbers is associated with negative numbers’ absolute or signed values remains controversial. In this study, through three experiments, the coding level of the magnitude and the spatial-direction is manipulated. In the first experiment, participants are required to code the magnitude and spatial-direction explicitly by using a magnitude classification task. In the second experiment, participants are forced to code the magnitude implicitly as (...) well as to code the spatial-direction explicitly by utilizing a cuing task. In the third experiment, participants are obliged to code the magnitude explicitly as well as to code the spatial-direction implicitly by adopting a magnitude and arrow-direction classification tasks with Go/No-Go responses. The results show that the absolute value of negative numbers associates with space when the magnitude of negative numbers is explicitly coded, no matter employing the explicit or implicit spatial-direction; the signed value of negative numbers associates with space under the condition of implicit magnitude as well as explicit spatial-direction. In conclusion, the current study indicates that the SNARC effect of negative numbers is variable in different conditions, and the type of SNARC effect about negative numbers is modulated by the joint coding level of the magnitude and spatial-direction. (shrink)

There is a venerable philosophical tradition that views human beings as intrinsically rational, though even the most ardent defender of this view would admit that under certain circumstances people’s decisions and thought processes can be very irrational indeed. When people are extremely tired, or drunk, or in the grip of rage, they sometimes reason and act in ways that no account of rationality would condone. About thirty years ago, Amos Tversky, Daniel Kahneman and a number of other psychologists began (...) reporting findings suggesting much deeper problems with the traditional idea that human beings are intrinsically rational animals. What these studies demonstrated is that even under quite ordinary circumstances where fatigue, drugs and strong emotions are not factors, people reason and make judgments in ways that systematically violate familiar canons of rationality on a wide array of problems. Those first surprising studies sparked the growth of a major research tradition whose impact has been felt in economics, political theory, medicine and other areas far removed from cognitive science. In Section 2, we will sketch a few of the better known experimental findings in this area. We’ve chosen these particular findings because they will play a role at a later stage of the paper. For readers who would like a deeper and more systematic account of the fascinating and disquieting research on reasoning and judgment, there are now several excellent texts and anthologies available. (shrink)

Information changes as it is passed from person to person, with this process of cultural transmission allowing the minds of individuals to shape the information that they transmit. We present mathematical models of cultural transmission which predict that the amount of information passed from person to person should affect the rate at which that information changes. We tested this prediction using a function-learning task, in which people learn a functional relationship between two variables by observing the values of those variables. (...) We varied the total number of observations and the number of those observations that take unique values. We found an effect of the number of observations, with functions transmitted using fewer observations changing form more quickly. We did not find an effect of the number of unique observations, suggesting that noise in perception or memory may have affected learning. (shrink)