Results for 'neuroprotection'

22 found
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  1.  19
    Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease?Rinat Tabakman, Shimon Lecht & Philip Lazarovici - 2004 - Bioessays 26 (1):80-90.
    Parkinsonism (PD) is a neurodegenerative disorder of the brain resulting in dopamine deficiency caused by the progressive death of dopaminergic neurons. PD is characterized by a combination of rigidity, poverty of movement, tremor and postural instability. Selegiline is a selective and irreversible propargylamine type B monoamine oxidase (MAO‐B) inhibitor. This drug, which inhibits dopamine metabolism, has been effectively used in the treatment of PD. However, its therapeutic effects are compromised by its many neurotoxic metabolites. To circumvent this obstacle, a novel (...)
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  2.  39
    Neuroprotective effects of yoga practice: age-, experience-, and frequency-dependent plasticity.Chantal Villemure, Marta ÄŒeko, Valerie A. Cotton & M. Catherine Bushnell - 2015 - Frontiers in Human Neuroscience 9.
  3.  13
    Neuroprotection Becomes Reality.Maxwell S. Damian - 2004 - In C. Machado & D. E. Shewmon (eds.), Brain Death and Disorders of Consciousness. Plenum. pp. 143--150.
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  4.  31
    Neuroprotective effect of ginseng against alteration of calcium binding proteins immunoreactivity in the mice hippocampus after chronic radiofrequency exposure.Maskey Dhiraj, Kim Myeung Ju & Kim Hyung Gun - 2015 - Frontiers in Human Neuroscience 9.
  5.  14
    Neuroprotection in late life attention-deficit/hyperactivity disorder: A review of pharmacotherapy and phenotype across the lifespan. [REVIEW]Cintya Nirvana Dutta, Leonardo Christov-Moore, Hernando Ombao & Pamela K. Douglas - 2022 - Frontiers in Human Neuroscience 16:938501.
    For decades, psychostimulants have been the gold standard pharmaceutical treatment for attention-deficit/hyperactivity disorder (ADHD). In the United States, an astounding 9% of all boys and 4% of girls will be prescribed stimulant drugs at some point during their childhood. Recent meta-analyses have revealed that individuals with ADHD have reduced brain volume loss later in life (>60 y.o.) compared to the normal aging brain, which suggests that either ADHD or its treatment may be neuroprotective. Crucially, these neuroprotective effects were significant in (...)
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  6.  84
    Sport-related neurotrauma and neuroprotection: Are Return-to-play protocols justified by paternalism?L. Syd M. Johnson - 2014 - Neuroethics 1 (8):15-26.
    Sport-related neurotrauma annually affects millions of athletes worldwide. The return-to-play protocol (RTP) is the dominant strategy adopted by sports leagues and organizations to manage one type of sport-related neurotrauma: concussions. RTPs establish guidelines for when athletes with concussions are to be removed from competition or practice, and when they can return. RTPs are intended to be neuroprotective, and to protect athletes from some of the harms of sport-related concussions, but there is athlete resistance to and noncompliance with RTPs. This prompts (...)
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  7.  20
    Neuroprotective Effects of Kuromanin Chloride Against Glutamatergic Excitotoxicity in Neuroblastoma Cells.Heba Nasser, Hidaya M. A. Kader & Fadwa Al Mughairbi - 2019 - Frontiers in Human Neuroscience 13.
  8.  37
    Gems from past: Neuroprotective effects of Bhilawinol and Anacardic acid against Glutamate-induced excitotoxicity in PC-12 cells.Rukhsana Nawaz, Faisal Khan, Amina Hassan, Nailah Mahmood, Heba Ahmed Naser, Alia Ali Al Shamali & Fadwa Al Mughairbi - 2019 - Frontiers in Human Neuroscience 13.
  9.  21
    From old remedy to modern therapy: Neuroprotective effects of Semecarpus Anacardium on the l-Monosodium Glutamate treated rats and neuronal cells.Fadwa Al Mughairbi, Faisal Khan, Saima Ilyas, Yasmeen Shad & Muhammad Iqbal Choudhary - 2019 - Frontiers in Human Neuroscience 13.
  10.  51
    Brain Atrophy as a Measure of Neuroprotective Drug Effects in Multiple Sclerosis: Influence of Inflammation.Tatiana Koudriavtseva & Caterina Mainero - 2016 - Frontiers in Human Neuroscience 10.
  11.  41
    Expanding roles for AMP‐activated protein kinase in neuronal survival and autophagy.Jeroen Poels, Miloš R. Spasić, Patrick Callaerts & Koenraad K. Norga - 2009 - Bioessays 31 (9):944-952.
    AMP‐activated protein kinase (AMPK) is an evolutionarily conserved cellular switch that activates catabolic pathways and turns off anabolic processes. In this way, AMPK activation can restore the perturbation of cellular energy levels. In physiological situations, AMPK senses energy deficiency (in the form of an increased AMP/ATP ratio), but it is also activated by metabolic insults, such as glucose or oxygen deprivation. Metformin, one of the most widely prescribed anti‐diabetic drugs, exerts its actions by AMPK activation. However, while the functions of (...)
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  12.  22
    ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease.Shlomo Sragovich, Avia Merenlender-Wagner & Illana Gozes - 2017 - Bioessays 39 (11):1700054.
    Activity-dependent neuroprotective protein, discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder, including cognitive and motor deficits, the ADNP syndrome. One of the most important cellular processes associated with ADNP is the autophagy pathway, recently discovered by us as a key player in the pathophysiology of schizophrenia. In this regard, given the link between the microtubule and (...)
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  13.  17
    Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial.Alba Castells-Sánchez, Francesca Roig-Coll, Rosalía Dacosta-Aguayo, Noemí Lamonja-Vicente, Pere Torán-Monserrat, Guillem Pera, Alberto García-Molina, José Maria Tormos, Pilar Montero-Alía, Antonio Heras-Tébar, Juan José Soriano-Raya, Cynthia Cáceres, Sira Domènech, Marc Via, Kirk I. Erickson & Maria Mataró - 2022 - Frontiers in Human Neuroscience 16.
    Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise, computerized cognitive training and a combined groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited. In this study we report intervention-related changes in plasma biomarkers and structural-MRI and how they (...)
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  14.  18
    Early Life Stress and the Fate of Kynurenine Pathway Metabolites.Jeremy D. Coplan, Roza George, Shariful A. Syed, Annalam V. Rozenboym, Jean E. Tang, Sasha L. Fulton & Tarique D. Perera - 2021 - Frontiers in Human Neuroscience 15.
    Early life stress precedes alterations to neuro-immune activation, which may mediate an increased risk for stress-related psychiatric disorders, potentially through alterations of central kynurenine pathway metabolites, the latter being relatively unexplored. We hypothesized that ELS in a non-human primate model would lead to a reduction of neuroprotective and increases of neurotoxic KP metabolites. Twelve adult female bonnet macaques reared under conditions of maternal variable foraging demand were compared to 27 age- and weight-matched non-VFD-exposed female controls. Baseline behavioral observations of social (...)
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  15.  22
    Exogenous Ketones and Lactate as a Potential Therapeutic Intervention for Brain Injury and Neurodegenerative Conditions.Naomi Elyse Omori, Geoffrey Hubert Woo & Latt Shahril Mansor - 2022 - Frontiers in Human Neuroscience 16:846183.
    Metabolic dysfunction is a ubiquitous underlying feature of many neurological conditions including acute traumatic brain injuries and chronic neurodegenerative conditions. A central problem in neurological patients, in particular those with traumatic brain injuries, is an impairment in the utilization of glucose, which is the predominant metabolic substrate in a normally functioning brain. In such patients, alternative substrates including ketone bodies and lactate become important metabolic candidates for maintaining brain function. While the potential neuroprotective benefits of ketosis have been recognized for (...)
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  16.  20
    VEGF once regarded as a specif ic angiogenic factor, now implicated in neur oprotein.Erik Storkebaum, Diether Lambrechts & Peter Carmeliet - 2004 - Bioessays 26 (9):943-954.
    Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor (VEGF)A is a key signal in the induction of vessel growth (a process termed angiogenesis). Though initial studies, now a decade ago, indicated that VEGF is an endothelial cell‐specific factor, more recent findings revealed that VEGF also has direct effects on neural cells. Genetic studies showed that mice with reduced VEGF levels develop adult‐onset motor neuron degeneration, reminiscent of the human neurodegenerative disorder amyotrophic lateral sclerosis (ALS). (...)
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  17.  36
    Melatonin Secretion during a Short Nap Fosters Subsequent Feedback Learning.Christian D. Wiesner, Valentia Davoli, David Schürger, Alexander Prehn-Kristensen & Lioba Baving - 2018 - Frontiers in Human Neuroscience 11:304534.
    Sleep helps to protect and renew hippocampus-dependent declarative learning. Less is known about forms of learning that mainly engage the dopaminergic reward system. Animal studies showed that exogenous melatonin modulates the responses of the dopaminergic reward system and acts as a neuroprotectant promoting memory. In humans, melatonin is mainly secreted in darkness during evening hours supporting sleep. In this study, we investigate the effects of a short period of daytime sleep (nap) and endogenous melatonin on reward learning. Twenty-seven healthy, adult (...)
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  18.  20
    Neural Synchrony During Naturalistic Information Processing Is Associated With Aerobically Active Lifestyle and Cardiorespiratory Fitness in Cognitively Intact Older Adults.Tamir Eisenstein, Nir Giladi, Talma Hendler, Ofer Havakuk & Yulia Lerner - 2022 - Frontiers in Human Neuroscience 16.
    The functional neural mechanisms underlying the cognitive benefits of aerobic exercise have been a subject of ongoing research in recent years. However, while most neuroimaging studies to date which examined functional neural correlates of aerobic exercise have used simple stimuli in highly controlled and artificial experimental conditions, our everyday life experiences require a much more complex and dynamic neurocognitive processing. Therefore, we have used a naturalistic complex information processing fMRI paradigm of story comprehension to investigate the role of an aerobically (...)
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  19.  23
    Trehalose against Alzheimer's Disease: Insights into a Potential Therapy.Masoomeh Khalifeh, Morgayn I. Read, George E. Barreto & Amirhossein Sahebkar - 2020 - Bioessays 42 (8):1900195.
    Trehalose is a natural disaccharide with a remarkable ability to stabilize biomolecules. In recent years, trehalose has received growing attention as a neuroprotective molecule and has been tested in experimental models for different neurodegenerative diseases. Although the underlying neuroprotective mechanism of trehalose's action is unclear, one of the most important hypotheses is autophagy induction. The chaperone‐like activity of trehalose and the ability to modulate inflammatory responses has also been reported. There is compelling evidence that the dysfunction of autophagy and aggregation (...)
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  20. Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring.Daniel Stoessel, Jan-Patrick Stellmann, Anne Willing, Birte Behrens, Sina C. Rosenkranz, Sibylle C. Hodecker, Klarissa H. Stürner, Stefanie Reinhardt, Sabine Fleischer, Christian Deuschle, Walter Maetzler, Daniela Berg, Christoph Heesen, Dirk Walther, Nicolas Schauer, Manuel A. Friese & Ole Pless - 2018 - Frontiers in Human Neuroscience 12:378428.
    Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing-remitting subtype (RRMS), primary neurodegenerative disease (Parkinson’s disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate (...)
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  21.  58
    ‘No Time to be Lost!’: Ethical Considerations on Consent for Inclusion in Emergency Pharmacological Research in Severe Traumatic Brain Injury in the European Union.Erwin J. O. Kompanje - 2007 - Science and Engineering Ethics 13 (3):371-381.
    Severe Traumatic Brain Injury (TBI) remains a major cause of death and disability afflicting mostly young adult males and elderly people, resulting in high economic costs to society. Therapeutic approaches focus on reducing the risk on secondary brain injury. Specific ethical issues pertaining in clinical testing of pharmacological neuroprotective agents in TBI include the emergency nature of the research, the incapacity of the patients to informed consent before inclusion, short therapeutic time windows, and a risk-benefit ratio based on concept that (...)
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  22.  37
    The emerging role of cystatins in Alzheimer's disease.Eva Žerovnik - 2009 - Bioessays 31 (6):597-599.
    Recently opposing effects of cysteine protease inhibitors, the human cystatins, on neurodegeneration have been reported. Human cystatin C is a risk factor for late‐onset Alzheimer's disease (AD), whereas human stefin B (cystatin B) has no direct involvement in AD. Conflicting data show that their target protease, cathepsin B, might be anti‐amyloidogenic, helping in amyloid‐beta (Aβ) clearance or, instead, might be involved in Aβ production. Some reports claim that cystatin C binds soluble Aβ, making transgenic animals healthier, others, in contrast, that (...)
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