Being Known is a response to a philosophical challenge which arises for every area of thought: to reconcile a plausible account of what is involved in the truth of statements in a given area with a credible account of how we can know those statements. Christopher Peacocke presents a framework for addressing the challenge, a framework which links both the theory of knowledge and the theory of truth with the theory of concept-possession.

In Known for Love, pastor Casey Hough provides a biblical and theological framework for thinking through the hard situations we encounter with family and friends. Drawing from a well of faithful biblical scholars, Hough provides insights for everyday Christians living in a sexually broken world. Known for Love gives us the wisdom and courage we need to live into these days with faithful and truly loving hearts.

New methods to analyse social media data provide a powerful way to know publics and capture what they say and do. At the same time, access to these methods is uneven, with corporations and governments tending to have best access to relevant data and analytics tools. Critics raise a number of concerns about the implications dominant uses of data mining and analytics may have for the public: they result in less privacy, more surveillance and social discrimination, and they provide new (...) ways of controlling how publics come to be represented and so understood. In this paper, we consider if a different relationship between the public and data mining might be established, one in which publics might be said to have greater agency and reflexivity vis-à-vis data power. Drawing on growing calls for alternative data regimes and practices, we argue that to enable this different relationship, data mining and analytics need to be democratised in three ways: they should be subject to greater public supervision and regulation, available and accessible to all, and used to create not simply known but reflexive, active and knowing publics. We therefore imagine conditions in which data mining is not just used as a way to know publics, but can become a means for publics to know themselves. (shrink)

In this paper I will be arguing that there are cases in which a subject, S, should have known that p, even though, given her state of evidence at the time, she was in no position to know it. My argument for this result will involve making two claims. The uncontroversial claim is this: S should have known that p when another person has, or would have, legitimate expectations regarding S’s epistemic condition, the satisfaction of these expectations would (...) require that S knows that p, and S fails to know that p. The controversial claim is that these three conditions are sometimes jointly satisfied. I will spend the majority of my time defending the controversial claim. I will argue that there are two main sources of legitimate expectations regarding another’s epistemic condition: participation in a legitimate social practice ; and moral and epistemic expectations more generally . In developing my position on this score, I will have an opportunity to defend the doctrine that there are “practice-generated entitlements” to expect certain things, where it can happen that the satisfaction of these expectations requires another’s having certain pieces of knowledge; to contrast practice-generated entitlements to expect with epistemic reasons to believe; to defend the idea that moral and epistemic standards themselves can be taken to reflect legitimate expectations we have of each other; to compare the “should have known” phenomenon with a widely-discussed phenomenon in the ethics literature—that of culpable ignorance; and finally to suggest the bearing of the “should have known” phenomenon to epistemology itself. (shrink)

Background: Although attention to healthcare ethics in rural areas has increased, specific focus on rural palliative care is still largely under-studied and under-theorized. The purpose of this study was to gain a deeper understanding of the values informing good palliative care from rural individuals' perspectives. Methods: We conducted a qualitative ethnographic study in four rural communities in Western Canada. Each community had a population of 10, 000 or less and was located at least a three hour travelling distance by car (...) from a specialist palliative care treatment centre. Data were collected over a 2-year period and included 95 interviews, 51 days of field work and 74 hours of direct participant observation where the researchers accompanied rural healthcare providers. Data were analyzed inductively to identify the most prevalent thematic values, and then coded using NVivo. Results: This study illuminated the core values of knowing and being known, being present and available, and community and mutuality that provide the foundation for ethically good rural palliative care. These values were congruent across the study communities and across the stakeholders involved in rural palliative care. Although these were highly prized values, each came with a corresponding ethical tension. Being known often resulted in a loss of privacy. Being available and present created a high degree of expectation and potential caregiver strain. The values of community and mutuality created entitlement issues, presenting daunting challenges for coordinated change. Conclusions: The values identified in this study offer the opportunity to better understand common ethical tensions that arise in rural healthcare and key differences between rural and urban palliative care. In particular, these values shed light on problematic health system and health policy changes. When initiatives violate deeply held values and hard won rural capacity to address the needs of their dying members is undermined, there are long lasting negative consequences. The social fabric of rural life is frayed. These findings offer one way to re-conceptualize healthcare decision making through consideration of critical values to support ethically good palliative care in rural settings. (shrink)

In normative decision theory, the weight of an uncertain event in a decision is governed solely by the probability of the event. A large body of empirical research suggests that a single notion of probability does not accurately capture peoples' reactions to uncertainty. As early as the 1920s, Knight made the distinction between cases where probabilities are known and where probabilities are unknown. We distinguish another case –- the unknowable uncertainty –- where the missing information is unavailable to all. (...) We propose that missing information influences the attractiveness of a bet contingent upon an uncertain event, especially when the information is available to someone else. We demonstrate that the unknowable uncertainty –- falls in preference somewhere in between the known and the known uncertainty. (shrink)

This is a brief summary of 18 well-known objections to utilitarianism. It is meant to be able to function as a 2 page handout, so the reference list is limited to objectors.

This article suggests evidence for and reasons why prior acquisition may either facilitate or inhibit acquisition of a new construction. It investigates acquisition of the German passive and future constructions which contain a lexical verb with either the auxiliary sein “to be” or werden “to become”, and are related through these to potential supporting constructions. We predicted that a supported construction should be acquired earlier, faster, and unusually rapidly. An inhibited construction should show an extended depressed usage. We analyzed a (...) dense corpus of a German boy between 2;0 and 5;0. He acquired the sein- before the werden-passive. The former was supported by his prior acquisition of the sein copula, whereas the werden-passive itself supported one werden copula construction. He acquired the werden-future extremely slowly due to the hindrance of a semantically identical construction. These results fit with an emergentist approach in which apparently “sudden” acquisition is still due to gradual learning mechanisms. (shrink)

These are just a few examples of scientific illiteracy — inane misconceptions that could have been avoided with a smidgen of freshman science. (For those afraid to ask: pencil “lead” is carbon; hydrogen fuel takes more energy to produce than it releases; all living things contain genes; a clone is just a twin.) Though we live in an era of stunning scientific understanding, all too often the average educated person will have none of it. People who would sneer at the (...) vulgarian who has never read Virginia Woolf will insouciantly boast of their ignorance of basic physics. Most of our intellectual magazines discuss science only when it bears on their political concerns or when they can portray science as just another political arena. As the nation’s math departments and biotech labs fill up with foreign students, the brightest young Americans learn better ways to sue one another or to capitalize on currency fluctuations. And all this is on top of our nation’s endless supply of New Age nostrums, psychic hot lines, creationist textbook stickers and other flimflam. (shrink)

This paper studies the role that known bounds on message transmission times in a computer network play on the evolution of the epistemic state over time. A connection to cones of causal influence analogous to, and more general than, light cones is presented. Focusing on lower bounds on message transmission times, an analysis is presented of how knowledge about when others are guaranteed to be ignorant about an event of interest can arise. This has implications in competitive settings, in (...) which knowing about another’s ignorance can provide an advantage. (shrink)

O. R. Jones; VIII—Things Known Without Observation, Proceedings of the Aristotelian Society, Volume 61, Issue 1, 1 June 1961, Pages 129–150, https://doi.org/10.

Mammalian mitochondrial DNA (mtDNA) replication and repair have been studied intensively for the last 50 years. Although recently advances in elucidating the molecular mechanisms of mtDNA maintenance and the proteins involved in these have been made, there are disturbing gaps between the existing theoretical models and experimental observations. Conflicting data and hypotheses exist about the role of RNA and ribonucleotides in mtDNA replication, but also about the priming of replication and the formation of pathological rearrangements. In the presented review, we (...) have attempted to match these loose ends and draft consensus where it can be found, while identifying outstanding issues for future research. (shrink)

Computational drug repositioning has been proven as a promising and efficient strategy for discovering new uses from existing drugs. To achieve this goal, a number of computational methods have been proposed, which are based on different data sources of drugs and diseases. These methods approach the problem using either machine learning- or network-based models with an assumption that similar drugs can be used for similar diseases to identify new indications of drugs. Therefore, similarities between drugs and between diseases are usually (...) used as inputs. In addition, known drug-disease associations are also needed for the methods as prior information. It should be noted that those associations are still not well established due to the fact that many of marketed drugs have been withdrawn and this could affect the outcome of the methods. In this study, we propose a novel method named RLSDR to find new uses of drugs. More specifically, it relies on a semi-supervised learning model, Regularized Least Square, thus it does not require definition of non-drug-disease associations as previously proposed machine learning-based methods. In addition, the similarity between drugs measured by chemical structures of drug compounds and the similarity between diseases which share phenotypes can be represented in a form of either similarity network or similarity matrix as inputs of the method. Moreover, instead of using a gold-standard set of known drug-disease associations, we construct an artificial set of the associations based on known disease-gene and drug-target associations. Experiment results demonstrate that RLSDR achieves better prediction performance on the artificial set of drug-disease associations than that on the gold-standard ones in terms of area under the Receiver Operating Characteristic curve. In addition, it outperforms two representative network-based methods irrespective of the prior information of drug-disease associations. Novel indications for a number of drugs are also identified and validated by evidences from a different data resource. (shrink)

There are few doubts about the significance of science and technology for modern human culture and society. But as historians, we are still struggling to find appropriate descriptive terms to capture the broad processes of transformation brought about by “techno-science,” the merging of technical production and modern institutionalized science. This dissertation argues that the term “experience” may serve as such an analytic lens in the specific historical setting of German aviation research from the 1920s through 1945. I reconstruct, on the (...) one hand, the theorization of experience as a concept by the technical physicist Paul von Handel, influenced by the British astronomer Sir Arthur Eddington’s distinction between "scientific" and "everyday" experience. On the other hand, I use the term as a historian’s analytic concept to investigate practices in the context of flight experiments that I take to be constitutive of my historical actors’ experiences. These are recordings of experimental pilots’ cognitive judgements and bodily actions, some of them—such as in-flight note taking—continuous with older cultural technologies. On both of these levels of analysis, I explore the different resonances of “experience” as a term with a legacy as a central epistemological concept in the modern sciences, and as capturing the changing everyday reality in an increasingly technicized environment. My analysis of the textual theorization and simultaneous practical constitution of "techno-scientific experience" serves to read in a new light the story of the pilot and physicist Melitta Schiller-Stauffenberg. Of Jewish descent, Schiller chose to work for the Luftwaffe, the German air force, until her death in 1945 on a flight searching for her husband, Count Alexander Stauffenberg, who was imprisoned after his brother’s failed attempt to assassinate Hitler. The concept and practical reality of “experience” are key to understanding the two striking choices Schiller made as intrinsically connected: the professional choice of working simultaneously as a pilot and a physicist, and the political choice of supporting the Reich’s war effort. Schiller’s story may be understood as exemplifying the fragile identity of the experiencing and the knowing self in 20th-century techno-scientific modernity. (shrink)

Large protein assemblies are usually the effectors of major cellular processes. The intricate cell homeostasis network is divided into numerous interconnected pathways, each controlled by a set of protein machines. One of these master regulators is the CCR4‐NOT complex, which ultimately controls protein expression levels. This multisubunit complex assembles around a scaffold platform, which enables a wide variety of well‐studied functions from mRNA synthesis to transcript decay, as well as other tasks still being identified. Solving the structure of the entire (...) CCR4‐NOT complex will help to define the distribution of its functions. The recently published three‐dimensional reconstruction of the complex, in combination with the known crystal structures of some of the components, has begun to address this. Methodological improvements in structural biology, especially in cryoelectron microscopy, encourage further structural and protein‐protein interaction studies, which will advance our comprehension of the gene expression machinery. (shrink)

In normative decision theory, the weight of an uncertain event in a decision is governed solely by the probability of the event. A large body of empirical research suggests that a single notion of probability does not accurately capture peoples' reactions to uncertainty. As early as the 1920s, Knight made the distinction between cases where probabilities are known and where probabilities are unknown. We distinguish another case –- the unknowable uncertainty –- where the missing information is unavailable to all. (...) We propose that missing information influences the attractiveness of a bet contingent upon an uncertain event, especially when the information is available to someone else. We demonstrate that the unknowable uncertainty –- falls in preference somewhere in between the known and the known uncertainty. (shrink)

Volume 20, Issue 4, May 2020, Page 106-108.

An assertion is existentially known if and only if: (i) the speaker knows that the sentence she uses to make the assertion expresses a true proposition; (ii) she makes the assertion based on that knowledge; and (iii) she does not believe, have justification for, or know the proposition asserted. Accordingly, if existentially known assertions could be made correctly—as argued by Charlie Pelling in his ‘Assertion and the Provision of Knowledge’—this would show that the norm of assertion cannot be (...) the speaker's belief in, justification for or knowledge of the proposition. In this paper, I try to show that Pelling's argument is inconclusive, as it rests on two assumptions which can be resisted. In turn, I offer a pair of alternative strategies to explain how we can deal with existentially known assertions under the assumption that the speaker's knowledge is the norm of assertion. (shrink)

Spermatozoa reach the fallopian tube during ovulation by traveling through the female reproductive tract mucus. This non‐Newtonian viscoelastic medium facilitates spermatozoon movement to accomplish fertilization or, in some cases, blocks spermatozoon movement, leading to infertility. While rheological properties are known to affect spermatozoon motility with in vitro models using synthetic polymers, their precise effects in vivo are understudied. This paper reviews the rheological measurements of reproductive tract mucus during ovulation in humans and model animals, focusing on viscosity and its (...) potential effect on spermatozoa. Mucus viscosity in the female reproductive tract's different compartments is poorly understood. While information on this subject is incomplete, most mammals appear to have a viscosity decrease along their female reproductive tracts. Based on this sparse information, we hypothesize that viscosity changes in female reproductive tracts may guide spermatozoa to eggs, a novel concept that could improve our understanding of reproductive biology. (shrink)

There are not only true or false solutions, there are also false questions. The task of philosophy is not to provide answers or solutions, but to submit to critical analysis the questions themselves, to make us see how the very way we perceive a problem is an obstacle to its solution. This holds especially for today’s public debates on ecological threats, on lack of faith, on democracy and the “war on terror”, in which the “unknown knowns”, the silent presuppositions we (...) are not aware of, determine our acts. (shrink)

According to a classic but nowadays discarded philosophical theory, perceptual experience is a complex of nonconceptual sensory states and full-blown propositional beliefs. This classical dual-component theory of experience is often taken to be obsolete. In particular, there seem to be cases in which perceptual experience and belief conflict: cases of known illusions, wherein subjects have beliefs contrary to the contents of their experiences. Modern dual-component theories reject the belief requirement and instead hold that perceptual experience is a complex of (...) nonconceptual sensory states and some other sort of conceptual state. The most popular modern dual-component theory appeals to sui generis propositional attitudes called ‘perceptual seemings’. This article argues that the classical dual-component theory has the resources to explain known illusions without giving up the claim that the conceptual components of experience are beliefs. The classical dual-component view, though often viewed as outdated and implausible, should be regarded as a serious contender in contemporary debates about the nature of perceptual experience. (shrink)

Background: Although attention to healthcare ethics in rural areas has increased, specific focus on rural palliative care is still largely under-studied and under-theorized. The purpose of this study was to gain a deeper understanding of the values informing good palliative care from rural individuals' perspectives. Methods: We conducted a qualitative ethnographic study in four rural communities in Western Canada. Each community had a population of 10, 000 or less and was located at least a three hour travelling distance by car (...) from a specialist palliative care treatment centre. Data were collected over a 2-year period and included 95 interviews, 51 days of field work and 74 hours of direct participant observation where the researchers accompanied rural healthcare providers. Data were analyzed inductively to identify the most prevalent thematic values, and then coded using NVivo. Results: This study illuminated the core values of knowing and being known, being present and available, and community and mutuality that provide the foundation for ethically good rural palliative care. These values were congruent across the study communities and across the stakeholders involved in rural palliative care. Although these were highly prized values, each came with a corresponding ethical tension. Being known often resulted in a loss of privacy. Being available and present created a high degree of expectation and potential caregiver strain. The values of community and mutuality created entitlement issues, presenting daunting challenges for coordinated change. Conclusions: The values identified in this study offer the opportunity to better understand common ethical tensions that arise in rural healthcare and key differences between rural and urban palliative care. In particular, these values shed light on problematic health system and health policy changes. When initiatives violate deeply held values and hard won rural capacity to address the needs of their dying members is undermined, there are long lasting negative consequences. The social fabric of rural life is frayed. These findings offer one way to re-conceptualize healthcare decision making through consideration of critical values to support ethically good palliative care in rural settings. (shrink)

This paper discusses what it means to be a good sport. It offers an account of sportsmanship rooted in the proper understanding of the limited role each participant plays during a specific sporting contest. It aims at showing that, from a fallibilist perspective, although it may perhaps be logically possible for a single play to win or lose a sporting event, it makes epistemologically no sense to single out a particular game action, moment or decision as the crucial one which (...) determined victory or defeat. Our view, we shall argue, is consistent with the empirical nature of sporting activities. Since there can be no such a thing as a perfect game, and because no single known human mind is in a position to know with any degree of certainty how each act of game-playing relates to the outcome of a whole game, it makes almost no sense to assign whole-game success or failure to single acts of brilliance or failure. (shrink)

Given recent discussions of personal privacy, or more particularly, its invasion via the internet, it is not surprising to find the issue of personal privacy emerging regarding God’s relation to our private lives. Two different and opposing views of this God-person relation have surfaced in the literature: ‘God and Privacy’ by Falls-Corbitt and Michael McLain, and ‘Privacy and Control’ by Scott Davison. I discuss key elements in both sides of this debate. Even though I will register my sympathy with both (...) sides, I claim that both fail to grasp what I call the existential depth of the God-person relationship. (shrink)

This paper provide the first extended discussion in the philosophical literature of the epistemic significance of the phenomenon of “being known” and the relationship it has to reparations that are distinctively epistemic. Drawing on a framework provided by the United Nations of the “right to know,” it is argued that victims of gross violations and injustices not only have the right to know what happened, but also the right to be known—to be a giver of knowledge to others (...) about their own experiences. It is shown that such victims can suffer epistemic wrongs by being rendered invisible, vilified or demonized, or systematically distorted, and that these ways of not being known demand epistemic reparations. While there are traditional reparations that are epistemic in nature, such as memorialization and education, it is argued that there is a prior and arguably more important epistemic reparation—knowing victims of gross violations and injustices in the sense of bearing witness. The paper concludes with a sketch of an epistemological picture to underwrite this notion of epistemic reparations, one that significantly expands the traditional picture by including epistemic duties that are imperfect in nature and concern actions in addition to beliefs. (shrink)

The legal protection of well-known trademarks is an exception to the fundamental principles of trademark law, i.e. territorality, registration and „speciality“. The well-known trademark is protected even if it had not been registered according to the national legal regulation of that state, in which protection is sought. The well-known trademark can also be protected even in respect to the goods and (or) services which are not similar to those for which the well-known trademark is used or (...) registered (in case the trademark is registered). (shrink)

Informed and guided by ecosystemic thinking, the author addresses the question: What do we need to learn for the sake of dwelling and flourishing with our ‘natural others’ (human beings and all else that exists in our planet) in our era of technological dominance and perverse economic growth which, like a runaway train, continues to accelerate at the expense of natural, social and human capital? Through the storied experiences of Jean Jacques Rousseau, Karl Marx, and Max Weber, the fundamental character (...) of dwelling is interpreted as being-at-home in our world by safeguarding, caring and being a gracious guest in our mutual relationship with natural others. As earthly dwellers the author makes a case for the need to _ever learn_ to be _Guardians_ and _Gracious Guests_ of our natural others by bringing heart and soul into our relationships, including business relationships. This reflective article concludes with three practical exercises for being a Guardian and a Gracious Guest that can be used in organizations and in classrooms. Practical, not in terms of “how-to” but rather practice as a choice and decision between possibilities. (shrink)