Much of what we understand about heterochromatin formation in mammals has been extrapolated from forward genetic screens for modifiers of position‐effect variegation (PEV) in the fruit fly Drosophila melanogaster. The recent identification of the HUSH (Human Silencing Hub) complex suggests that more recent evolutionary developments contribute to the mechanisms underlying PEV in human cells. Although HUSH‐mediated repression also involves heterochromatin spreading through the reading and writing of the repressive H3K9me3 histone modification, clear orthologues of HUSH subunits are (...) not found in Drosophila but are conserved in vertebrates. Here we compare the insights into the mechanisms of PEV derived from genetic screens in the fly, the mouse and in human cells, review what is currently known about the HUSH complex and discuss the implications of HUSH‐mediated silencing for viral latency. Future studies will provide mechanistic insight into HUSH complex function and reveal the relationship between HUSH and other epigenetic silencing complexes. (shrink)

Nucleosomes “talk” to each other about their modification state to form extended domains of modified histones independently of the underlying DNA sequence. At the same time, DNA elements promote modification of nucleosomes in their vicinity. How do these site-specific and histone-based activities act together to regulate spreading of histone modifications along the genome? How do they enable epigenetic memory to preserve cell identity? Many models for the dynamics of repressive histone modifications emphasize the role of strong positive feedback loops, (...) which reinforce histone modifications by recruiting histone modifiers to preexisting modifications. Recent experiments question that repressive histone modifications are self-sustained independently of their genomic context, thereby indicating that histone-based feedback is relatively weak. In the present review, current models for the dynamics of histone modifications are compared and it is suggested that limitation of histone-based feedback is key to intrinsic confinement of spreading and coexistence of short- and long-term memory at different genomic loci. See also the video abstract here: https://youtu.be/3bxr_xDEZfQ. Communication between nucleosomes and site-specific recruitment of histone modifiers act together to enable spreading and epigenetic memory of histone modifications. This review essay compares current models that describe these phenomena and outline a mechanism for how epigenetic short- and long-term memory can coexist in the same cell. (shrink)

Acetylation of histones is an essential element regulating chromatin structure and transcription. MYST (Moz, Ybf2/Sas3, Sas2, Tip60) proteins form the largest family of histone acetyltransferases and are present in all eukaryotes. Surprisingly, until recently this protein family was poorly studied. However, in the last few years there has been a substantial increase in interest in the MYST proteins and a number of key studies have shown that these chromatin modifiers are required for a diverse range of cellular processes, both in (...) health and disease. Translocations affecting MYST histone acetyltransferases can lead to leukemia and solid tumors. Some members of the MYST family are required for the development and self‐renewal of stem cell populations; other members are essential for the prevention of inappropriate heterochromatin spreading and for the maintenance of adequate levels of gene expression. In this review we discuss the function of MYST proteins in vivo. (shrink)

The use of Drosophila chromosomal rearrangements and transposon constructs involving the white gene reveals the existence of repressive chromatin domains that can spread over considerable genomic distances. One such type of domain is found in heterochromatin and is responsible for classical position‐effect variegation. Another type of repressive domain is established, beginning at specific sequences, by complexes of Polycomb Group proteins. Such complexes, which normally regulate the expression of many genes, including the homeotic loci, are responsible for silencing, white gene (...) variegation, pairing‐dependent effects and insertional targeting. (shrink)

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, (...) when mutated, act as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function. (shrink)

Heterochromatin remains condensed throughout the cell cycle, is generally transcriptionally inert and is built and maintainedbygroupsoffactors witheachgroupmember sharing a similar function. In mammals, these groups include sequence-specific transcriptional repressors, functionalRNAandproteinsinvolvedinDNAandhistone methylation. Heterochromatin is cemented together via interactions within and between each protein group and ismaintainedbythecell’sreplicationmachinery.Itcanbe constitutive (permanent) or facultative (developmentally regulated) and be any size, from a gene promotor to a whole genome. By studying the formation of facultative heterochromatin, we have gained information about how heterochromatin (...) is assembled. We have discovered that there are many different architectural plans for the building of heterochromatin, leading to a seemingly never-ending variety of heterochromatic loci, with each built according to a general rule. (shrink)

We focus here on the intercalary heterochromatin (IH) of Drosophila melanogaster and, in particular, its molecular properties. In the polytene chromosomes of Drosophila, IH is represented by a reproducible set of dense bands scattered along the euchromatic arms. IH contains mainly unique DNA sequences, and shares certain features with other heterochromatin types such as pericentric, telomeric, and PEV‐induced heterochromatin, the inactive mammalian X‐chromosome and the heterochromatized male chromosome set in coccids. These features are transcriptional silencing, chromatin compactness, (...) late DNA replication, underrreplication or elimination in somatic cells, and formation of the heterochromatin state in early embryogenesis. Post‐translational modification of histones and the specific nonhistone protein complexes are shown to participate in the establishment and maintenance of silencing for all heterochromatin types. Many IH regions contain binding sites for HP1 and/or Pc‐G proteins and all the regions are sites of heterochromatin‐associated SuUR protein. Some IH regions are known to contain homeotic genes. Summarizing these data, we suggest that IH regions comprise stable inactivated genes, whose silencing is developmentally programmed. BioEssays 25:1040–1051, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The centromere is the region of the chromosome where the kinetochore forms. Kinetochores are the attachment sites for spindle microtubules that separate duplicated chromosomes in mitosis and meiosis. Kinetochore formation depends on a special chromatin structure containing the histone H3 variant CENP‐A. The epigenetic mechanisms that maintain CENP‐A chromatin throughout the cell cycle have been studied extensively but little is known about the mechanism that targets CENP‐A to naked centromeric DNA templates. In a recent report published in Science,1 such de (...) novo centromere assembly of CENP‐A is shown to be dependent on heterochromatin and the RNA interference pathway. BioEssays 30:526–529, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In eukaryotic cells, heterochromatin is typically composed of tandem DNA repeats and plays crucial roles in gene expression and genome stability. It has been reported that silencing at individual units within tandem heterochromatin repeats exhibits a position‐dependent variation. However, how the heterochromatin is organized at an individual repeat level remains poorly understood. Using a novel genetic approach, our recent study identified a conserved protein Rex1BD required for position‐dependent silencing within heterochromatin repeats. We further revealed that Rex1BD (...) interacts with the 14‐3‐3 protein to regulate heterochromatin silencing by linking RNAi and HDAC pathways. In this review, we discuss how Rex1BD and the 14‐3‐3 protein coordinate to modulate heterochromatin organization at the individual repeat level, and comment on the biological significance of the position‐dependent effect in heterochromatin repeats. We also identify the knowledge gaps that still need to be unveiled in the field. (shrink)

The spread of unethical behavior in organizations has mainly been studied in terms of processes occurring in a general social context, rather than in terms of actors’ reactions in the context of their specific social relationships. This paper introduces a dynamic social network analysis framework in which this spread is conceptualized as the result of the reactions of perpetrators, victims, and observers to an initial act of unethical behavior. This theoretical framework shows that the social relationships of the actors involved (...) in an initial act impact in multiple ways the likelihood that unethical behavior spreads. It reveals furthermore that social relationships may change in the wake of unethical behavior, such that indirect negative consequences can arise for organizations. The proposed framework provides a basis for the development of a formal stochastic actor-oriented model of network dynamics which would enable simulations of the spread of unethical behavior. (shrink)

Localist models of spreading activation (SA) and models assuming distributed representations offer very different takes on semantic priming, a widely investigated paradigm in word recognition and semantic memory research. In this study, we implemented SA in an attractor neural network model with distributed representations and created a unified framework for the two approaches. Our models assume a synaptic depression mechanism leading to autonomous transitions between encoded memory patterns (latching dynamics), which account for the major characteristics of automatic semantic priming (...) in humans. Using computer simulations, we demonstrated how findings that challenged attractor‐based networks in the past, such as mediated and asymmetric priming, are a natural consequence of our present model’s dynamics. Puzzling results regarding backward priming were also given a straightforward explanation. In addition, the current model addresses some of the differences between semantic and associative relatedness and explains how these differences interact with stimulus onset asynchrony in priming experiments. (shrink)

Heterochromatin protein 1 (HP1) is a positive regulator of active transcription in euchromatin. HP1 was first identified inDrosophila melanogasteras a major component of heterochromatin. Most eukaryotes have at least three isoforms of HP1, which are conserved in overall structure but localize differentially to heterochromatin and euchromatin. Although initial studies revealed a key role for HP1 in heterochromatin formation and gene silencing, recent progress has shed light on additional roles for HP1 in processes such as euchromatic gene (...) expression. Recent studies have highlighted the importance of HP1‐mediated gene regulation in euchromatin. Here, we focus on recent advances in understanding the role of HP1 in active transcription in euchromatin and how modification and localization of HP1 can regulate distinct functions for this protein in different contexts. (shrink)

The four experiments presented support Boyer's theory that counterintuitive concepts have transmission advantages that account for the commonness and ease of communicating many non-natural cultural concepts. In Experiment 1, 48 American college students recalled expectation-violating items from culturally unfamiliar folk stories better than more mundane items in the stories. In Experiment 2, 52 American college students in a modified serial reproduction task transmitted expectation-violating items in a written narrative more successfully than bizarre or common items. In Experiments 3 and 4, (...) these findings were replicated with orally presented and transmitted stimuli, and found to persist even after three months. To sum, concepts with single expectation-violating features were more successfully transmitted than concepts that were entirely congruent with category-level expectations, even if they were highly unusual or bizarre. This transmission advantage for counterintuitive concepts may explain, in part, why such concepts are so prevalent across cultures and so readily spread. (shrink)

Passion plays a crucial role in entrepreneurial activity, while its positive spillover to the family and community domains is scant. We proposed an integrated enrichment framework of “work-family-community” based on the literature in the field. Drawing upon the matching samples of entrepreneurs' individuals, families, and communities in the China Labor-force Dynamics Survey database, we identified a significant positive spillover effect into the family and community domains and explored the moderating role of the entrepreneur's perceived personal control. The empirical results indicate (...) that entrepreneurs with higher passion experience higher subjective wellbeing related to family members and have a higher likelihood of engagement in prosocial behaviors. Perceived personal control positively moderates the spillover of passion to life and economic satisfaction. The spread of an entrepreneurial role model's peer effect and the contagion of entrepreneurial passion have a significant positive impact on entrepreneurial behavior in a cluster. Synthesizing our findings, we contribute to the literature concerning work-family enrichment, entrepreneurial passion, and the spillover-crossover model and offer important implications for entrepreneurs' role transition tension. (shrink)

The current study investigates the infiltration of code-switches into Jordanian social settings. It is also to examine Jordanians' attitudes toward the spread of code-switches in different social settings, the rationale behind the spread of code-switches, the role of media, types of code-switches and linguistic dominance. To illustrate the existence of this phenomenon, a corpus consisting of more than two hundred code-switches has been built up. Most importantly, to measure Jordanians' attitudes toward the phenomenon, more than three hundred questionnaires have been (...) delivered in Amman city. (shrink)

Mainstream epistemologists have recently made a few isolated attempts to demonstrate the particular ways, in which specific types of knowledge are partly social. Two promising cases in point are Lackey’s dualism in the epistemology of testimony and Goldberg’s process reliabilist treatment of testimonial and coverage-support justification. What seems to be missing from the literature, however, is a general approach to knowledge that could reveal the partly social nature of the latter anytime this may be the case. Indicatively, even though Lackey (...) :345–361, 2007) has recently launched an attack against the Credit Account of Knowledge on the basis of testimony, she has not classified her view of testimonial knowledge into any of the alternative, general approaches to knowledge. Similarly, even if Goldberg’s attempt to provide a process reliabilist explanation of the social nature of testimonial knowledge is deemed satisfactory, his attempt to do the same in the case of coverage-support justification does not deliver the requisite result. This paper demonstrates that CAK can in fact provide, pace Lackey’s renunciation of the view, a promising account of the social nature of both testimonial and coverage-supported knowledge. Additionally, however, it can display further explanatory power by also revealing the social nature of knowledge produced on the basis of epistemic artifacts. Despite their disparities, all these types of knowledge count as partly social in nature, because in all these cases, according to CAK, the epistemic credit for the individual agent’s true belief must spread between the individual agent and certain parts of her epistemic community. Accordingly, CAK is a promising candidate for providing a unified approach to several and, perhaps all possible, instances of what we may call ‘weak epistemic anti-individualism’ within mainstream epistemology: i.e., the claim that the nature of knowledge can occasionally be both social and individual at the same time. (shrink)

If phenomenal experience is a physical phenomenon, it must occur at some spatial and temporal location. Can consciousness be situated in such a strong sense? Although the importance of embodiment and situatedness is often mentioned, most neuroscientists and philosophers alike consider phenomenal experience as an outcome of neural activity. In this paper, the question I would raise is whether the physical underpinnings of conscious experience may be identical with processes temporally and spatially extended beyond the boundary of the skull and (...) the skin. The resulting model of situated consciousness is dubbed the Spread Mind. The hypothesis is verifiable empirically. The model outlines a form of vehicle phenomenal externalism more radical than Clark’s extended mind or Dretske’s content phenomenal externalism. (shrink)

With the growth of online commerce, companies have created virtual communities where users can create posts and reply to posts about the company’s products. VCs can be represented as networks, with users as nodes and relationships between users as edges. Information propagates through edges. In VC studies, it is important to know how the number of topics concerning the product grows over time and what network features make a user more influential than others in the information-spreading process. The existing (...) literature has not provided a quantitative method with which to determine key points during the topic emergence process. Also, few researchers have considered the link between multilayer physical features and the nodes’ spreading influence. In this paper, we present two new ideas to enrich network theory as applied to VCs: a novel application of an adjusted coefficient of determination to topic growth and an adjustment to the Jaccard coefficient to measure the connection between two users. A two-layer network model was first used to study the spread of topics through a VC. A random forest method was then applied to rank various factors that might determine an individual user’s importance in topic spreading through a VC. Our research provides insightful ways for enterprises to mine information from VCs. (shrink)

Bankruptcy of listed companies or shareholders delisting usually causes the crisis spreading in stock markets. Based on the systematic analysis of the epidemic diseases and rumors spreading on the complex networks, the SIR model is introduced to research the crisis spreading in shareholding networks of listed companies and their main holders on the basis of the data about ownership structure in Chinese Stock Markets. The characteristics of shareholding networks are studied, and the parameters for the SIR model (...) are obtained by empirical approach. Then, the numerical computation method is successfully used to analyze the crisis spreading in the networks when the networks meet random failures or intentional attacks. We find the networks have good robustness against the random failures. However, the crisis will spread at a high speed and cause catastrophic damage if there are some failures or attacks on hub vertices in the networks. Under this condition, the networks show obvious vulnerability. Last but not least, the controllability of the networks under the condition of intentional attacks and random failures is studied. The results show that if the network is controlled globally, it is more reliable to allow a politically good new or an appropriate exciting economical policy to play the role in orienting markets under the control of public opinions as the crisis occurs. However, under normal circumstances, controlling a small part of driver vertices representing listed companies, applying appropriate control strategies, and using its characteristics of high efficiency of sending information can effectively control the stock market. Our research provides a new reference to further exploration about the transmission mechanism of the crisis based SIR model and further research on the controllability of crisis spreading in financial markets. (shrink)

With the rapid development of social network in recent years, the threshold of information dissemination has become lower. Most of the time, rumors, as a special kind of information, are harmful to society. And once the rumor appears, the truth will follow. Considering that the rumor and truth compete with each other like light and darkness in reality, in this paper, we study a rumor spreading model in the homogeneous network called 2SIH2R, in which there are both spreader1 and (...) spreader2. In this model, we introduced discernible mechanism and confrontation mechanism to quantify the level of people's cognitive abilities and the competition between the rumor and truth. By mean-field equations, steady-state analysis, and numerical simulations in a generated network which is closed and homogeneous, some significant results can be given: the higher the discernible rate of the rumor, the smaller the influence of the rumor; the stronger the confrontation degree of the rumor, the smaller the influence of the rumor; the larger the average degree of the network, the greater the influence of the rumor but the shorter the duration. The model and simulation results provide a quantitative reference for revealing and controlling the spread of the rumor. (shrink)

This article discusses the haul stage which is held once a year on the date of death of the fourth former President of the Republic of Indonesia, namely Abdurrahman Wahid (Gus Dur), which demonstrates harmonious relations between adherents of different religions in Indonesia. Consequently, the haul rituals have become vehicles for affirming understandings of the interfaith dialogue. This study aims to map the use of haul rituals to promote interfaith value. Analysing YouTube videos, this study finds that interfaith dialogue forms (...) have been reflected in: (1) declarations of a cross-religious ideology, (2) the involvement of interfaith figures, and (3) the inclusivist discourses themselves. Gus Dur’s haul, thus, has provided collaborative spaces wherein interfaith dialogue value can be sustainably structured.Contribution: This research contributes to exploration of the haul stage, which takes place annually on the death anniversary of former Indonesian President Abdurrahman Wahid (Gus Dur). (shrink)

Is consciousness all in the head, or might the minimal physical substrate for some forms of conscious experience include the goings on in the (rest of the) body and the world? Such a view might be dubbed (by analogy with Clark and Chalmers’s ( 1998 ) claims concerning ‘the extended mind’) ‘the extended conscious mind’. In this article, I review a variety of arguments for the extended conscious mind, and find them flawed. Arguments for extended cognition, I conclude, do not (...) generalize to arguments for an extended conscious mind. (shrink)

This book, first published in 1989, contains a spirited debate between eminent economists, journalists, and publishers about the spread of economic ideas. Using many of the same ideas as do the rhetorical and sociological philosophical schools, the contributors to this book discuss the spread of economic ideas in readily understandable English. The examination of the flow of ideas among economists and from economists to the public is followed by a discussion of the public policy use and abuse of these concepts. (...) A final section provides insights into the funding of ideas and the incentives to make economics more relevant. The dialogue among the book's contributors provides both the lay reader and the interested professional with fascinating insights into what happens behind the scenes in academia, publishing, and journalism. (shrink)

The question of the body spans across the work of Jean-Luc Nancy, from Noli me tangere, to Corpus and Jacques Derrida’s dialogue with Nancy in On Touching. In constant conversation with Christianity (“This is my body” or Dis-Enclosure), corporeality in Nancy can be summarised using the figure of the “exposed body (corps ex-peausé)”: a demonstration of the surface of the skin (peau) and an exposition of the self to the other in the sense of a “staging” (Corpus). In my work, (...) the concept of the “spread body,” situated between Descartes’ “extended body” and Husserl’s “lived body,” is also one of a confrontation with the “This is my body” of Christianity (The Wedding Feast of the Lamb). In confronting one with the other, it is a matter of seeing how my expansion of the body, says something different than, or articulates differently, Jean-Luc Nancy’s exposition of the body, this time drawn from the biological side though nevertheless without ceasing to be intentional. It is certainly a matter of philosophy, but also of ethics, in the possibility of describing such a body, especially in the suffering situation of palliative care (Ethics of the Spread Body). (shrink)

This paper analyses what kind of conspiracy theories are generated because of the emergence and spread of diseases. Conspiracy theory narratives that are generated during the different kinds of pandemics – cholera, AIDS and COVID-19 – are described and analysed, with special attention given to COVID-19 conspiracy theories. We raise a conceptual issue for further research indicating that the disease-related conspiracies do not perfectly square with the current psychological interpretations of conspiracy beliefs.

A usual argument in finance refers to no arbitrage opportunities for the positivity of the bid-ask spread. Here we follow the decision theory approach and show that if positivity of the bid-ask spread is identified with strong risk aversion for an expected utility market-maker, this is no longer true for a rank-dependent expected utility one. For such a decision-maker only a very weak form of risk aversion is required, a result which seems more in accordance with his actual behavior. We (...) conclude by showing that the no-trade interval result of Dow and Werlang (1992a) remains valid for a rank-dependent expected utility market-maker merely exhibiting this weak form of risk aversion. (shrink)

Provides a comprehensive introduction to the major philosophical theories attempting to explain the workings of language.

Group beneficial norms are common in human societies. The persistence of such norms is consistent with evolutionary game theory, but existing models do not provide a plausible explanation for why they are common. We show that when a model of imitation used to derive replicator dynamics in isolated populations is generalized to allow for population structure, group beneficial norms can spread rapidly under plausible conditions. We also show that this mechanism allows recombination of different group beneficial norms arising in..

In this paper, I analyze a type of externalist enactivism defended by Riccardo Manzotti. Such radical versions of enactivism are gaining more attention, especially in cognitive science and cognitive robotics. They are radical in that their notion of representation is purely referential, and content is conflated with reference. Manzotti follows in the footsteps of early causal theories of reference that had long been shown to be inadequate. It is commonly known that radical versions of externalism may lead to difficulties with (...) the notion of representation, especially if they cannot help themselves with the notion of syntax. I argue that a type of externalism present in Manzotti’s enactivism may well lead to anti-representationalism. (shrink)

Convergence of model projections is often considered by climate scientists to be an important objective in so far as it may indicate the robustness of the models’ core hypotheses. Consequently, the range of climate projections from a multi-model ensemble, called “model spread”, is often expected to reduce as climate research moves forward. However, the successive Assessment Reports of the Intergovernmental Panel on Climate Change indicate no reduction in model spread, whereas it is indisputable that climate science has made improvements in (...) its modelling. In this paper, after providing a detailed explanation of the situation, we describe an epistemological setting in which a steady model spread is not doomed to be seen as negative, and is indeed compatible with a desirable evolution of climate models taken individually. We further argue that, from the perspective of collective progress, as far as the improvement of the products of a multi-model ensemble is concerned, reduction of model spread is of lower priority than model independence. (shrink)

DNA repetitions may provoke heterochromatinization. We explore here a model in which multiple cis‐acting sequences that display no silencing activity on their own (protosilencers) may cooperate to establish and maintain a heterochromatin domain efficiently. Protosilencers, first defined in budding yeast, have now been found in a wide range of genomes where they appear to stabilize and to extend the propagation of heterochromatin domains. Strikingly, isolated or moderately repeated protosilencers can also be found in promoters where they participate in (...) transcriptional activation and have insulation functions. This suggests that the proper juxtaposition of a threshold number of protosilencers converts them from neutral or transactivating elements into ones that nucleate heterochromatin. Interactions might be transient or permanent, and are likely to occur over distances by looping. This model provides a conceptual framework for as varied phenomena as telomere‐driven silencing in Drosophila, X inactivation in mammals, and rDNA silencing in S. cerevisiae. It may also account for the silencing that occurs when multiple copies of a transgene are inserted in tandem. BioEssays 24:828–835, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This paper distinguishes processes potentially contributing to interpersonal anxiety transfer, including object-directed social appraisal, empathic worry, and anxiety contagion, and reviews evidence for their operation. We argue that these anxiety-transfer processes may be exploited strategically when attempting to regulate relationship partners’ emotion. More generally, anxiety may serve as either a warning signal to other people about threat (alerting function) or an appeal for emotional support or practical help (comfort-seeking function). Tensions between these two interpersonal functions may account for mutually incongruent (...) interpersonal responses to expressed anxiety, including mistargeted interpersonal regulation attempts. Because worry waxes and wanes over time as a function of other people's ongoing reactions, interpersonal interventions may help to alleviate some of its maladaptive consequences. (shrink)

This commentary sides with Pessoa and his colleagues in arguing that some types of perceptual filling-in are linked with a spread of cortical activity, a hypothesis that has often been rejected on philosophical grounds. Some recent data are discussed that strengthen this linking hypothesis and indicate that a spread of cortical activity may be essential for normal surface perception.

Background Retraction is a mechanism for alerting readers to unreliable material and other problems in the published scientific and scholarly record. Retracted publications generally remain visible and searchable, but the intention of retraction is to mark them as “removed” from the citable record of scholarship. However, in practice, some retracted articles continue to be treated by researchers and the public as valid content as they are often unaware of the retraction. Research over the past decade has identified a number of (...) factors contributing to the unintentional spread of retracted research. The goal of the Reducing the Inadvertent Spread of Retracted Science: Shaping a Research and Implementation Agenda (RISRS) project was to develop an actionable agenda for reducing the inadvertent spread of retracted science. This included identifying how retraction status could be more thoroughly disseminated, and determining what actions are feasible and relevant for particular stakeholders who play a role in the distribution of knowledge. -/- Methods These recommendations were developed as part of a year-long process that included a scoping review of empirical literature and successive rounds of stakeholder consultation, culminating in a three-part online workshop that brought together a diverse body of 65 stakeholders in October–November 2020 to engage in collaborative problem solving and dialogue. Stakeholders held roles such as publishers, editors, researchers, librarians, standards developers, funding program officers, and technologists and worked for institutions such as universities, governmental agencies, funding organizations, publishing houses, libraries, standards organizations, and technology providers. Workshop discussions were seeded by materials derived from stakeholder interviews (N = 47) and short original discussion pieces contributed by stakeholders. The online workshop resulted in a set of recommendations to address the complexities of retracted research throughout the scholarly communications ecosystem. -/- Results The RISRS recommendations are: (1) Develop a systematic cross-industry approach to ensure the public availability of consistent, standardized, interoperable, and timely information about retractions; (2) Recommend a taxonomy of retraction categories/classifications and corresponding retraction metadata that can be adopted by all stakeholders; (3) Develop best practices for coordinating the retraction process to enable timely, fair, unbiased outcomes; and (4) Educate stakeholders about pre- and post-publication stewardship, including retraction and correction of the scholarly record. -/- Conclusions Our stakeholder engagement study led to 4 recommendations to address inadvertent citation of retracted research, and formation of a working group to develop the Communication of Retractions, Removals, and Expressions of Concern (CORREC) Recommended Practice. Further work will be needed to determine how well retractions are currently documented, how retraction of code and datasets impacts related publications, and to identify if retraction metadata (fails to) propagate. Outcomes of all this work should lead to ensuring retracted papers are never cited without awareness of the retraction, and that, in public fora outside of science, retracted papers are not treated as valid scientific outputs. (shrink)

The dynamic models are proposed to investigate the influence node activity has on rumor spreading process in both homogeneous and heterogeneous networks. Different from previous studies, we believe that the activity of nodes in complex networks affects the process of rumor spreading. An active node can have contact with all the nodes it directly links to, while an inactive node could only interact with its active neighbors. We explore the joint effort of activity rate, spreading rate and (...) network topology on rumor spreading process by mean-field equations and numerical simulations, which reveals that there exists a critical curve consisting of critical activity rate and spreading rate; meanwhile, activity rate and spreading rate both have influence on the final rumor spreading scale. (shrink)

Eukaryotes organize certain chromosomal intervals into domains capable of si lencing most genes. Examples of silencing domains include the HML/HMR loci and subtelomeric chromatin in yeast, the Barr body X chromosome in mammals, and the pericentric heterochromatin of Drosophila. Silencing chromatin is often correlated with more regularized nucleosomal array than that found in active chromatin, and transcriptional activators appear to be missing from their target sites in silent chromatin. In Drosophila, gene silencing by heterochromatin is often variegated, indicating (...) that a gene may escape silencing in some cells. In a recent study, Ahmad and Henikoff(1) show that a yeast activator can compete successfully with Drosophila heterochromatic silencing factors for target sites in DNA. This competition, together with developmental change in the stability of heterochromatin itself, decides the transcriptional state for a gene subject to heterochromatin repression. BioEssays 23:767–771, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Conspiracy theories are spreading faster than ever and pose a real danger to our societies. It is natural to accuse the consumers of conspiracy theories of irrationality – that they are either not looking at or appropriately sensitive to all the available evidence. In this paper, I attempt to determine if we can make sense of this general idea. I argue that we cannot: conspiracy theories do not spread because the people who believe them are irrational – at least, (...) not necessarily so. In addition, I explore some alternative strategies for responding to the problem of the spread of conspiracy theories. I argue that in addition to confrontational strategies such as social shaming, we need more constructive programs of community activism to battle the spread of conspiracy theories. (shrink)