Results for 'drug therapy'

974 found
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  1.  81
    Drug therapy of attention deficit hyperactivity disorder: Current trends.Avinash De Sousa & Gurvinder Kalra - 2012 - Mens Sana Monographs 10 (1):45.
    Attention deficit hyperactivity disorder is a developmental disorder with an age onset prior to 7 years. Children with ADHD have significantly lower ability to focus and sustain attention and also score higher on impulsivity and hyperactivity. Stimulants, such as methylphenidate, have remained the mainstay of ADHD treatment for decades with evidence supporting their use. However, recent years have seen emergence of newer drugs and drug delivery systems, like osmotic release oral systems and transdermal patches, to mention a few. The (...)
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  2. Maintenance drug therapy in long-term treatment of depression.A. J. Gelenberg & G. L. Klerman - 1978 - In John Paul Brady & Harlow Keith Hammond Brodie, Controversy in psychiatry. Philadelphia: Saunders. pp. 279--301.
     
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  3.  59
    Beyond creativity: ADHD drug therapy as a moral Damper on a child's future success.Christian J. Krautkramer - 2005 - American Journal of Bioethics 5 (3):52 – 53.
    *The views represented in this article are those of the author and do not necessarily represent the views or policies of the American Medical Association.
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  4.  24
    Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study.Carani B. Sanjeevi, Pradeep Deshmukh, Swapna Muthusamy, Bhanu Prakash, V. S. Ananth, D. K. K. Vamsi, Vijay M. Bhagat & Bishal Chhetri - 2022 - Acta Biotheoretica 70 (2):1-28.
    The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and (...)
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  5.  12
    Analyzing and labeling evolution in modern drug therapy: Jeremy Greene, Flurin Condrau, and Elizabeth Watkins (eds): Therapeutic revolutions: pharmaceuticals and social change in the twentieth century. Chicago: University of Chicago Press, 2016, 321 pp, $40.00 PB.John P. Swann - 2021 - Metascience 30 (1):45-48.
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  6.  58
    A multi‐intervention approach on drug therapy can lead to a more appropriate drug use in the elderly. LIMM‐Landskrona Integrated Medicines Management.Anna Bergkvist, Patrik Midlöv, Peter Höglund, Lisa Larsson & Tommy Eriksson - 2009 - Journal of Evaluation in Clinical Practice 15 (4):660-667.
  7.  41
    Policy issues implied by technologies measuring patient adherence to prescribed drug therapies.Malcolm C. Brown - 1998 - Health Care Analysis 6 (4):317-318.
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  8.  14
    Reaching New Highs: Alternative Therapies for Drug Addicts.Kris Heggenhougen - 1997 - Jason Aronson.
    Considering the abysmal track record of orthodox drug rehabilitation programs, whereby a ten percent abstinence rate after one year of treatment is regarded as successful, a responsible introduction to viable alternative methodologies brings hope and promise along with new insight and information. Medical anthropologist H. K. Heggenhougen reviews the growing body of literature that describes and assesses traditional interventions rooted in other cultures , as well as therapies advanced through alternative achievements like acupuncture, biofeedback, and meditation. Besides exploring their (...)
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  9.  8
    Migrations in Humanistic Therapy: Turning Drug Users into Patients and Patients into Healthy Citizens in Southwest China.Sandra Teresa Hyde - 2011 - Body and Society 17 (2-3):183-204.
    This article explores the translation and migration of illegal drugs, humanistic therapies and political ideologies by focusing on China’s first residential community drug treatment center, called Sunlight. I argue that the migration of contemporary treatment therapies from one continent to another initiates certain practices that re-appropriate and remake drug-using bodies that live and work at Sunlight. Reviewing Sunlight ethnographically also allows for broader theoretical exploration. When bodies do not operate under the common trope of possessive individualism different forms (...)
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  10.  28
    Initiation Plants in Drug Addiction Treatment: The Purgahuasca Therapy.Miroslav Horák, Nahanga Verter & Kristina Somerlíková - 2021 - Anthropology of Consciousness 32 (1):33-54.
    Anthropology of Consciousness, Volume 32, Issue 1, Page 33-54, Spring 2021.
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  11.  9
    Systemic family therapy working with drug users.Sofija Georgievska - 2020 - Годишен зборник на Филозофскиот факултет/The Annual of the Faculty of Philosophy in Skopje 73:343-350.
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  12.  44
    Multidrug Therapy for HIV Infection: Dynamics of Immune System.Deepmala Kamboj & M. D. Sharma - 2019 - Acta Biotheoretica 67 (2):129-147.
    A mathematical model of the dynamics of the immune system is considered to illustrate the effect of its response to HIV infection, i.e. on viral growth and on T-cell dynamics. The specific immune response is measured by the levels of cytotoxic lymphocytes in a human body. The existence and stability analyses are performed for infected steady state and uninfected steady state. In order to keep infection under control, roles of drug therapies are analyzed in the presence of efficient immune (...)
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  13.  6
    Moral Attitudes Toward Pharmacologically Assisted Couples Therapy: An Experimental Bioethics Study of Real-World “Love Drugs”.Mey Bahar Buyukbabani, Brian D. Earp, Ivar Hannikainen, Tommaso Barba, Emilian Mihailov, David B. Yaden & Julian Savulescu - 2024 - American Journal of Bioethics Neuroscience 15 (4):239-243.
    In a recent study, Lantian and colleagues (2024) measured public attitudes toward the use of ‘love drugs’ as introduced through the work of Earp, Savulescu, and their collaborators. Use of a “revol...
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  14.  26
    Opportunities and Challenges in Translational Research: The Development of Photodynamic Therapy and Anti-Vascular Endothelial Growth Factor Drugs.Christina Kaiser Marko & Joan W. Miller - 2021 - Journal of Law, Medicine and Ethics 49 (1):19-24.
    The development of photodynamic therapy and anti-vascular endothelial growth factor agents have revolutionized the treatment of retinal diseases, transforming the retina subspecialty by ushering in an age of pharmacological treatments for a wide range of diseases, including age-related macular degeneration.
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  15.  33
    Moral Attitudes Toward Pharmacologically Assisted Couples Therapy: An Experimental Bioethics Study of Real-World “Love Drugs”.Mey Bahar Buyukbabani, Brian D. Earp, Ivar Hannikainen, Tommaso Barba, Emilian Mihailov, David B. Yaden & Julian Savulescu - 2024 - American Journal of Bioethics Neuroscience 15 (4):239-243.
    In a recent study, Lantian and colleagues (2024) measured public attitudes toward the use of ‘love drugs’ as introduced through the work of Earp, Savulescu, and their collaborators. Use of a “revol...
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  16.  19
    Greater Than Minimal Risk, No Direct Benefit – Bridging Drug Trials and Novel Therapy in Pediatric Populations.Benjamin S. Wilfond, Devan M. Duenas & Liza-Marie Johnson - 2020 - American Journal of Bioethics 20 (4):102-103.
    Volume 20, Issue 4, May 2020, Page 102-103.
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  17. A room with a view (and with a gene therapy drug) : gene therapy medicinal products and genetic tourism in Europe.Vera Lucia Raposo - 2023 - In Santa Slokenberga, Timo Minssen & Ana Nordberg, Governing, protecting, and regulating the future of genome editing: the significance of ELSPI perspectives. Boston: Brill/Nijhoff.
  18.  20
    Antiretroviral Therapy Coverage, Entrepreneurship, and Development in Low- and Middle-Income Countries.Cornelius A. Rietveld & Pankaj C. Patel - 2025 - Business and Society 64 (3):441-471.
    Improvements in the health capital of citizens are central to the development of countries. By exploiting steep decreases in antiretroviral drug prices and the subsequent increases in antiretroviral therapy (ART) coverage, we test whether the resulting improvements in the health of the population are associated with the prevalence of entrepreneurial activity and whether entrepreneurial activity strengthens the relationship between ART coverage and a country’s development. Drawing on a sample of 87 low- and middle-income countries (2006–2019), we find that (...)
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  19.  13
    The history and status of dopamine cell therapies for Parkinson's disease.Roger A. Barker, Anders Björklund & Malin Parmar - 2024 - Bioessays 46 (12):2400118.
    Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP). As such there has been much interest in repairing this pathway using transplants of dopamine neurons. This work which began (...)
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  20.  38
    Psychedelic Therapy as Form of Life.Nicolas Langlitz & Alex K. Gearin - 2024 - Neuroethics 17 (1):1-19.
    In the historical context of a crisis in biological psychiatry, psychedelic drugs paired with psychotherapy are globally re-emerging in research clinics as a potential transdiagnostic therapy for treating mood disorders, addictions, and other forms of psychological distress. The treatments are poised to soon shift from clinical trials to widespread service delivery in places like Australia, North America, and Europe, which has prompted ethical questions by social scientists and bioethicists. Taking a broader view, we argue that the ethics of psychedelic (...)
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  21.  21
    Epigenetic cancer therapy: Proof of concept and remaining challenges.Cora Mund & Frank Lyko - 2010 - Bioessays 32 (11):949-957.
    Over the past few years several drugs that target epigenetic modifications have shown clinical benefits, thus seemingly validating epigenetic cancer therapy. More recently, however, it has become clear that these drugs are either characterized by low specificity or that their target enzymes have low substrate specificity. As such, clinical proof‐of‐concept for epigenetic cancer therapies remains to be established. Human cancers are characterized by widespread changes in their genomic DNA methylation and histone modification patterns. Epigenetic cancer therapy aims to (...)
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  22.  32
    Drugs, genes and screens: The ethics of preventing and treating spinal muscular atrophy.Christopher Gyngell, Zornitza Stark & Julian Savulescu - 2020 - Bioethics 34 (5):493-501.
    Spinal muscular atrophy (SMA) is the most common genetic disease that causes infant mortality. Its treatment and prevention represent the paradigmatic example of the ethical dilemmas of 21st‐century medicine. New therapies (nusinersen and AVXS‐101) hold the promise of being able to treat, but not cure, the condition. Alternatively, genomic analysis could identify carriers, and carriers could be offered in vitro fertilization and preimplantation genetic diagnosis. In the future, gene editing could prevent the condition at the embryonic stage. How should these (...)
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  23.  18
    Turning a Drug Target into a Drug Candidate: A New Paradigm for Neurological Drug Discovery?Steven D. Buckingham, Harry-Jack Mann, Olivia K. Hearnden & David B. Sattelle - 2020 - Bioessays 42 (9):2000011.
    The conventional paradigm for developing new treatments for disease mainly involves either the discovery of new drug targets, or finding new, improved drugs for old targets. However, an ion channel found only in invertebrates offers the potential of a completely new paradigm in which an established drug target can be re‐engineered to serve as a new candidate therapeutic agent. The L‐glutamate‐gated chloride channels (GluCls) of invertebrates are absent from vertebrate genomes, offering the opportunity to introduce this exogenous, inhibitory, (...)
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  24.  14
    Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes.Jasmin Straube, Steven W. Lane & Therese Vu - 2021 - Bioessays 43 (10):2100125.
    The DNA hypomethylating agents (HMA) azacitidine (AZA) and decitabine (DAC) improve survival and transfusion independence in myelodysplastic syndrome (MDS) and enable a low intensity cytotoxic treatment for aged AML patients unsuitable for intensive chemotherapy, particularly in combination with novel agents. The proposed mechanism of AZA and DAC relies on active DNA replication and therefore patient responses are only observed after multiple cycles of treatment. Although extended dosing may provide the optimal scheduling, the reliance of injectable formulation of the drug (...)
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  25.  57
    Pharmacogenetic interventions, orphan drugs, and distributive justice: The role of cost-benefit analysis.Arti Rai - 2002 - Social Philosophy and Policy 19 (2):246-270.
    With the human genome mapped, and with the mapping of more than one hundred animal genomes in progress, the amount of genetic data available is increasing exponentially. This exponential increase in data is having an immediate impact on the process of drug development. By using techniques of information technology to manipulate data regarding the genes, proteins, and biochemical pathways associated with various diseases, scientists are beginning to be able to design drugs in a systematic fashion. In the context of (...)
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  26.  41
    Mammalian synthetic biology – from tools to therapies.Dominique Aubel & Martin Fussenegger - 2010 - Bioessays 32 (4):332-345.
    Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported. Here we focus on the latest generation of mammalian transgene control devices, highlight state‐of‐the‐art synthetic gene network design, and cover prototype therapeutic circuits. These will have an impact on future gene‐ and cell‐based therapies and help bring drug discovery into a new era. The inventory of biological parts that are essential for life on this planet is becoming increasingly (...)
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  27.  74
    Gene Therapy Oversight: Lessons for Nanobiotechnology.Susan M. Wolf, Rishi Gupta & Peter Kohlhepp - 2009 - Journal of Law, Medicine and Ethics 37 (4):659-684.
    Oversight of human gene transfer research presents an important model with potential application to oversight of nanobiology research on human participants. Gene therapy oversight adds centralized federal review at the National Institutes of Health's Office of Biotechnology Activities and its Recombinant DNA Advisory Committee to standard oversight of human subjects research at the researcher's institution and at the federal level by the Office for Human Research Protections. The Food and Drug Administration's Center for Biologics Evaluation and Research oversees (...)
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  28. Restoring Responsibility: Promoting Justice, Therapy and Reform Through Direct Brain Interventions.Nicole A. Vincent - 2014 - Criminal Law and Philosophy 8 (1):21-42.
    Direct brain intervention based mental capacity restoration techniques-for instance, psycho-active drugs-are sometimes used in criminal cases to promote the aims of justice. For instance, they might be used to restore a person's competence to stand trial in order to assess the degree of their responsibility for what they did, or to restore their competence for punishment so that we can hold them responsible for it. Some also suggest that such interventions might be used for therapy or reform in criminal (...)
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  29.  63
    Ethical and epistemic issues in direct-to-consumer drug advertising: where is patient agency? [REVIEW]Catherine A. Womack - 2013 - Medicine, Health Care and Philosophy 16 (2):275-280.
    Arguments for and against direct-to-consumer drug advertising (DTCA) center on two issues: (1) the epistemic effects on patients through access to information provided by the ads; and (2) the effects of such information on patients’ abilities to make good choices in the healthcare marketplace. Advocates argue that DTCA provides useful information for patients as consumers, including information connecting symptoms to particular medical conditions, information about new drug therapies for those conditions. Opponents of DTCA point out substantial omissions in (...)
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  30.  30
    Targeting tumor suppressor genes for cancer therapy.Yunhua Liu, Xiaoxiao Hu, Cecil Han, Liana Wang, Xinna Zhang, Xiaoming He & Xiongbin Lu - 2015 - Bioessays 37 (12):1277-1286.
    Cancer drugs are broadly classified into two categories: cytotoxic chemotherapies and targeted therapies that specifically modulate the activity of one or more proteins involved in cancer. Major advances have been achieved in targeted cancer therapies in the past few decades, which is ascribed to the increasing understanding of molecular mechanisms for cancer initiation and progression. Consequently, monoclonal antibodies and small molecules have been developed to interfere with a specific molecular oncogenic target. Targeting gain‐of‐function mutations, in general, has been productive. However, (...)
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  31.  4
    Logic-Based Therapy and Consultation - Theory and Applications.Elliot D. Cohen (ed.) - 2024 - Rowan & Littlefield.
    Logic-Based Therapy & Consultation (LBTC) is a popular modality of philosophical counseling developed by philosopher Elliot D. Cohen and the first one to have undergone a randomized, controlled efficacy study. Logic-Based Therapy and Consultation: Theory and Applications brings together leading LBTC researchers, trainers, and practitioners to provide the latest account of its theory and apply it to diverse populations including persons with mental health issues, children, athletes, persons with drug and alcohol addictions, persons in a detention center, (...)
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  32.  24
    The Efficacy of Cognitive Behavioral Therapy for Tic Disorder: A Meta-Analysis and a Literature Review.Songting Shou, Yuanliang Li, Guohui Fan, Qiang Zhang, Yurou Yan, Tiying Lv & Junhong Wang - 2022 - Frontiers in Psychology 13.
    BackgroundAt present, tic disorder has attracted the attention of medical researchers in many countries. More clinicians choose non-drug therapy, especially cognitive-behavioral therapy because of the cognitive side effects of drug therapy. However, few studies had assessed its efficacy. It is necessary to have a more comprehensive understanding of the literature quality of CBT and its intervention effect.MethodsIn this study, MEDLINE, Embase, and Cochrane were searched from the beginning to June 15, 2021 to study the efficacy (...)
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  33. Fair allocation of scarce therapies for COVID-19.Govind Persad, Monica E. Peek & Seema K. Shah - 2021 - Clinical Infectious Diseases 18:ciab1039.
    The U.S. FDA has issued emergency use authorizations for monoclonal antibodies for non-hospitalized patients with mild or moderate COVID-19 disease and for individuals exposed to COVID-19 as post-exposure prophylaxis. One EUA for an oral antiviral drug, molnupiravir, has also been recommended by FDA’s Antimicrobial Drugs Advisory Committee, and others appear likely in the near future. Due to increased demand because of the Delta variant, the federal government resumed control over the supply and asked states to ration doses. As future (...)
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  34.  24
    High-Priced Sickle Cell Gene Therapies Threaten to Exacerbate US Health Disparities and Establish New Pricing Precedents for Molecular Medicine.Frazer A. Tessema, Ameet Sarpatwari, Leah Z. Rand & Aaron S. Kesselheim - 2022 - Journal of Law, Medicine and Ethics 50 (2):380-384.
    Gene therapies to treat sickle cell disease are in development and are expected to have high costs. The large eligible population size — by far, the largest for a gene therapy — poses daunting budget challenges and threatens to exacerbate health disparities for Black patients, who make up the vast majority of American sickle cell patients.
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  35.  21
    The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidence.Mariusz Maziarz & Adrian Stencel - 2022 - History and Philosophy of the Life Sciences 44 (4):1-26.
    The current strategy of searching for an effective treatment for COVID-19 relies mainly on repurposing existing therapies developed to target other diseases. Conflicting results have emerged in regard to the efficacy of several tested compounds but later results were negative. The number of conducted and ongoing trials and the urgent need for a treatment pose the risk that false-positive results will be incorrectly interpreted as evidence for treatments’ efficacy and a ground for drug approval. Our purpose is twofold. First, (...)
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  36. Psychotropic drug use: Between healing and enhancing the mind.Toine Pieters & Stephen Snelders - 2009 - Neuroethics 2 (2):63-73.
    The making and taking of psychotropic drugs, whether on medical prescription or as self-medication, whether marketed by pharmaceutical companies or clamoured for by an anxious population, has been an integral part of the twentieth century. In this modern era of speed, uncertainty, pleasure and anguish the boundaries between healing and enhancing the mind by chemical means have been redefined. Long before Prozac would become a household name for an ‘emotional aspirin’ did consumers embrace the idea and practice of taking psychotropics (...)
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  37.  40
    Prescription for Love: An Experimental Investigation of Laypeople’s Relative Moral Disapproval of Love Drugs.Anthony Lantian, Jordane Boudesseul & Florian Cova - 2024 - American Journal of Bioethics Neuroscience 15 (4):218-233.
    New technologies regularly bring about profound changes in our daily lives. Romantic relationships are no exception to these transformations. Some philosophers expect the emergence in the near future of love drugs: a theoretically achievable biotechnological intervention that could be designed to strengthen and maintain love in romantic relationships. We investigated laypeople’s resistance to the use of such technologies and its sources. Across two studies (Study 1, French and Peruvian university students, N after exclusion = 186; Study 2, Amazon Mechanical Turk (...)
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  38.  12
    Cured to Death: The Effects of Prescription Drugs.Arabella Melville & Colin Johnson - 1983 - Stein & Day.
    A study of the international pharmaceutical industry discusses the uses and abuses of prescription drugs and details the dangers and adverse impact of disease treatment with drugs.
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  39.  29
    Talking therapy: The allopathic nihilation of homoeopathy through conceptual translation and a new medical language.Lyn Brierley-Jones - 2021 - History of the Human Sciences 34 (3-4):121-141.
    The 19th century saw the development of an eclectic medical marketplace in both the United Kingdom and the United States, with mesmerists, herbalists and hydrotherapists amongst the plethora of medical ‘sectarians’ offering mainstream (or ‘allopathic’) medicine stiff competition. Foremost amongst these competitors were homoeopaths, a group of practitioners who followed Samuel Hahnemann (1982[1810]) in prescribing highly dilute doses of single-drug substances at infrequent intervals according to the ‘law of similars’ (like cures like). The theoretical sophistication of homoeopathy, compared to (...)
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  40. Drug-Induced Impulse Control Disorders: A Prospectus for Neuroethical Analysis.Adrian Carter, Polly Ambermoon & Wayne D. Hall - 2010 - Neuroethics 4 (2):91-102.
    There is growing evidence that dopamine replacement therapy (DRT) used to treat Parkinson’s Disease can cause compulsive behaviours and impulse control disorders (ICDs), such as pathological gambling, compulsive buying and hypersexuality. Like more familiar drug-based forms of addiction, these iatrogenic disorders can cause significant harm and distress for sufferers and their families. In some cases, people treated with DRT have lost their homes and businesses, or have been prosecuted for criminal sexual behaviours. In this article we first examine (...)
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  41.  37
    Shadow Medicine: The Placebo in Conventional and Alternative Therapies by John S. Haller Jr.Ashley Graham Kennedy - 2019 - Kennedy Institute of Ethics Journal 29 (2):1-3.
    Placebos are much discussed in both the medical and philosophy of medicine literatures. Once narrowly defined as inert “sugar pills,”, they now are now most often taken to be “treatments that appear similar to experimental treatments, but that lack their characteristic components”. In addition to their use in the control groups of many clinical trials, placebos are also now widely recognized by medical practitioners to be powerful therapies in themselves, often outperforming conventional drug therapies in these studies.Given this, I (...)
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  42.  64
    When is coercive methadone therapy justified?Daniel D'Hotman, Jonathan Pugh & Thomas Douglas - 2018 - Bioethics 32 (7):405-413.
    Heroin use poses a significant health and economic burden to society, and individuals with heroin dependence are responsible for a significant amount of crime. Owing to its efficacy and cost-effectiveness, methadone maintenance therapy (MMT) is offered as an optional alternative to imprisonment for drug offenders in several jurisdictions. Some object to such 'MMT offers' on the basis that they involve coercion and thus invalidate the offender's consent to MMT. While we find these arguments unpersuasive, we do not attempt (...)
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  43.  56
    Drug induced alterations in dreaming: An exploration of the dream data terrain outside activation-synthesis.Jim F. Pagel - 2004 - Behavioral and Brain Sciences 27 (5):702-707.
    Two meta-analyses of pharmacological research are presented, demonstrating that psychoactive drugs have consistent effects on EEG and sleep outside of their effects on REM sleep, and demonstrating that drugs other than those affecting sleep neurotransmitter systems and REM sleep can also alter reported nightmare occurrence. These data suggest that the neurobiology data terrain outside activation-synthesis may include sleep and dream electrophysiology, cognitive reports of dreaming, effects of alterations in consciousness on dreaming, immunology and host defense, and clinical therapies for sleep (...)
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  44.  21
    Patient-Driven Drug Development.Jessica Flanigan - 2017 - In Dien Ho, Philosophical Issues in Pharmaceutics: Development, Dispensing, and Use. Dordrecht: Springer.
    Patient-driven drug development is an emerging approach to pharmaceutical research that is forged in rare-disease communities and patient advocacy networks. Patients and their advocates increasingly engage in drug discovery and influence early-stage drug research as clinical trial participants or through compassionate-use programs. Some advocacy groups and patients also influence which therapies are developed by financing promising treatments that otherwise would not secure funding. Though some critics of patient-driven drug development worry about the ethical and scientific implications (...)
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  45.  68
    Brave New Love: The Threat of High-Tech “Conversion” Therapy and the Bio-Oppression of Sexual Minorities.Brian D. Earp, Anders Sandberg & Julian Savulescu - 2014 - American Journal of Bioethics Neuroscience 5 (1):4-12.
    Our understanding of the neurochemical bases of human love and attachment, as well as of the genetic, epigenetic, hormonal, and experiential factors that conspire to shape an individual's sexual orientation, is increasing exponentially. This research raises the vexing possibility that we may one day be equipped to modify such variables directly, allowing for the creation of “high-tech” conversion therapies or other suspect interventions. In this article, we discuss the ethics surrounding such a possibility, and call for the development of legal (...)
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  46.  84
    Opioid Contracts and Random Drug Testing for People with Chronic Pain — Think Twice.Mark Collen - 2009 - Journal of Law, Medicine and Ethics 37 (4):841-845.
    It is common for physicians who prescribe opioids for chronic pain to have their patients sign an opioid contract in order to receive opioid therapy. A vast majority of these contracts contain a stipulation requiring patients to submit to random drug testing which screens for both licit and illicit drugs. Physicians who prescribe opioids may be concerned about prosecution and disciplinary actions; medication abuse and misuse; and addiction. Steven Passik et al. write, “…physicians still fear the risk of (...)
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  47.  3
    Exploring Ion Channel Magnetic Pharmacology: Are Magnetic Cues a Viable Alternative to Ion Channel Drugs?Vitalii Zablotskii, Tatyana Polyakova & Alexandr Dejneka - forthcoming - Bioessays:e202400200.
    We explore the potential of using magnetic cues as a novel approach to modulating ion channel expression, which could provide an alternative to traditional pharmacological interventions. Ion channels are crucial targets for pharmacological therapies, and ongoing research in this field continues to introduce new methods for treating various diseases. However, the efficacy of ion channel drugs is often compromised by issues such as target selectivity, leading to side effects, toxicity, and complex drug interactions. These challenges, along with problems like (...)
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  48.  20
    Mitochondria in the pathogenesis of lipodystrophy induced by anti‐HIV antiretroviral drugs: actors or bystanders?Andrea Cossarizza, Cristina Mussini & Alessandra Viganò - 2001 - Bioessays 23 (11):1070-1080.
    Effective therapies are now available that can stop the progression of HIV infection and significantly delay the onset of AIDS. The “highly active antiretroviral therapy” (HAART) is a combination of potent antiretroviral drugs such as viral protease inhibitors or nucleoside-analogue reverse-transcriptase inhibitors, that has a variety of serious side effects, including lipodystrophy, a pathology characterized by accumulation of visceral fat, breast adiposity, cervical fat-pads, hyperlipidemia, insulin resistance as well as fat wasting in face and limbs. There is still an (...)
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  49.  19
    Differential pharmacological regulation of drug efflux and pharmacoresistant schizophrenia.Mary Bebawy & Manoranjenni Chetty - 2008 - Bioessays 30 (2):183-188.
    Pharmacoresistant schizophrenia is a significant impediment to the successful management of the disease. The expression and function of P‐glycoprotein (P‐gp) has recently been implicated in this phenomenon. P‐gp is a multidrug efflux transporter that prevents drug substrates from crossing the blood–brain barrier (BBB). Although the direct interaction between individual antipsychotic agents and P‐gp has been demonstrated, the effect of antipsychotic drug combinations used in disease management on P‐gp transport function remains to be elucidated. This could have important clinical (...)
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    Is the Requirement for First-Person Experience of Psychedelic Drugs a Justified Component of a Psychedelic Therapist’s Training?Nathan Emmerich & Bryce Humphries - 2024 - Cambridge Quarterly of Healthcare Ethics 33 (4):548-557.
    Recent research offers good reason to think that various psychedelic drugs—including psilocybin, ayahuasca, ketamine, MDMA, and LSD—may have significant therapeutic potential in the treatment of various mental health conditions, including post-traumatic stress disorder, depression, existential distress, and addiction. Although the use of psychoactive drugs, such as Diazepam or Ritalin, is well established, psychedelics arguably represent a therapeutic step change. As experiential therapies, their value would seem to lie in the subjective experiences they induce. As it is the only way for (...)
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