The evolution of sex in eukaryotes represents a paradox, given the “twofold” fitness cost it incurs. We hypothesize that the mutational dynamics of the mitochondrial genome would have favored the evolution of sexual reproduction. Mitochondrial DNA (mtDNA) exhibits a high‐mutation rate across most eukaryote taxa, and several lines of evidence suggest that this high rate is an ancestral character. This seems inexplicable given that mtDNA‐encoded genes underlie the expression of life's most salient functions, including energy conversion. We propose (...) that negative metabolic effects linked to mitochondrial mutation accumulation would have invoked selection for sexual recombination between divergent host nuclear genomes in early eukaryote lineages. This would provide a mechanism by which recombinant host genotypes could be rapidly shuffled and screened for the presence of compensatory modifiers that offset mtDNA‐induced harm. Under this hypothesis, recombination provides the genetic variation necessary for compensatory nuclear coadaptation to keep pace with mitochondrial mutation accumulation. (shrink)

Alexandra Maryanski's cladistic analysis of the last common ancestor to humans and apes reveals biological propensities in hominoids for autonomy, individualism, and weak-tie formation. The evolution of emotional capacities in humans, and the neuroanatomical bases for these capacities, are viewed as representing one of the many compensatory mechanisms for overcoming the low sociality contained in humans’ape ancestry. Speculation on the selection forces involved in hominids’growing capacity to use complex arrays of emotions for mobilizing energy, attuning, sanctioning, moral coding, (...) exchanging and decision-making is conducted with an eye towards redirecting micro-level theorizing in sociology. (shrink)

the paper argues that it is possible to perceive a positive reconsideration about the importance of State role on social life and economic organization, in that democratic politics and redistributive, compensatory and interventive functions of the State are affirmed as directive forces of social evolution and socio-economic organization, by many groups of society, political parties and even intellectuals. Therefore, this positive role of the State, after a long time of supremacy of neoliberal positions and its disruption of State, (...) is oriented to pacification of social poverty produced by capitalist economy and to reinforce democratic political participation of citizens – something that current economic worldwide crisis makes more preeminent. So, the State is the core of democratic constitution of society itself, again , and it must be affirmed in this position and in the vindications of social movements and citizen initiatives about solid processes of political democracy, social justice and cultural recognition. (shrink)

The vertebrate retina is said to be inverted because the photoreceptors are oriented in the posterior direction and are thus unable to maximize photodetection under conditions of low illumination. The tapetum lucidum is a photoreflective structure located posterior to the photoreceptors in the eyes of some fish and terrestrial animals. The tapetum reflects light forward, giving incident photons a “second chance” to collide with a photoreceptor, substantially enhancing retinal photosensitivity in dim light. Across vertebrates (and arthropods), there are a wide (...) variety of tapeta that vary in structure, chemical composition, and even tissue architecture, indicating repeated convergent evolution. To date, the tapetum has not been observed in any cephalopod, however, which also possess a camera‐like eye, but with the retinal photoreceptors oriented in the anterior direction. We therefore hypothesize that the tapetum lucidum is a compensatory adaptation for the suboptimal design of the inverted retina of vertebrates. (shrink)

The multiple realizability thesis (MRT) is an important philosophical and psychological concept. It says any mental state can be constructed by multiple realizability (MR), meaning in many distinct ways from different physical parts. The goal of our study is to find if the MRT applies to the mental state of consciousness among animals. Many things have been written about MRT but the ones most applicable to animal consciousness are by Shapiro in a 2004 book called The Mind Incarnate and by (...) Polger and Shapiro in their 2016 work, The Multiple Realization Book. Standard, classical MRT has been around since 1967 and it says that a mental state can havevery manydifferent physical realizations, in a nearly unlimited manner. To the contrary, Shapiro’s book reasoned that physical, physiological, and historical constraints force mental traits to evolve in just a few, limited directions, which is seen as convergent evolution of the associated neural traits in different animal lineages. This is his mental constraint thesis (MCT). We examined the evolution of consciousness in animals and found that it arose independently in just three animal clades—vertebrates, arthropods, and cephalopod mollusks—all of which share many consciousness-associated traits: elaborate sensory organs and brains, high capacity for memory, directed mobility, etc. These three constrained, convergently evolved routes to consciousness fit Shapiro’s original MCT. More recently, Polger and Shapiro’s book presented much the same thesis but changed its name from MCT to a “modest identity thesis.” Furthermore, they argued against almost all the classically offered instances of MR in animal evolution, especially against the evidence of neural plasticity and the differently expanded cerebrums of mammals and birds. In contrast, we argue that some of these classical examples of MR are indeed valid and that Shapiro’s original MCT correction of MRT is the better account of the evolution of consciousness in animal clades. And we still agree that constraints and convergence refute the standard, nearly unconstrained, MRT. (shrink)

The quality of arm movements typically improves in the sub-acute phase of stroke affecting the upper extremity. Here, we used whole arm kinematic analysis during reaching movements to distinguish whether these improvements are due to true recovery or to compensation. Fifty-three participants with post-acute stroke performed ∼80 reaching movement tests during 4 weeks of training with the ArmeoSpring exoskeleton. All participants showed improvements in end-effector performance, as measured by movement smoothness. Four ArmeoSpring angles, shoulder horizontal rotation, shoulder elevation, elbow rotation, (...) and forearm rotation, were recorded and analyzed. We first characterized healthy joint coordination patterns by performing a sparse principal component analysis on these four joint velocities recorded during reaching tests performed by young control participants. We found that two dominant joint correlations [SH with elbow rotation and SE with forearm rotation] explained over 95% of variance of joint velocity data. We identified two clusters of stroke participants by comparing the evolution of these two correlations in all tests. In the “Recoverer” cluster, both joint correlations converged toward the respective correlations for control participants. Thus, Recoverers relearned how to generate smooth end-effector movements while developing joint movement patterns similar to those of control participants. In the “Compensator” cluster, at least one of the two joint correlations diverged from the corresponding correlation of control participants. Compensators relearned how to generate smooth end-effector movements by discovering various new compensatory movement patterns dissimilar to those of control participants. New compensatory patterns included atypical decoupling of the SE and forearm joints, and atypical coupling of the SH rotation and elbow joints. There was no difference in clinical impairment level between the two groups either at the onset or at the end of training as assessed with the Upper Extremity Fugl-Meyer scale. However, at the start of training, the Recoverers showed significantly faster improvements in end-effector movement smoothness than the Compensators. Our analysis can be used to inform neurorehabilitation clinicians on how to provide movement feedback during practice and suggest avenues for refining exoskeleton robot therapy to reduce compensatory patterns. (shrink)

The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently (...) proposed compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

An argument is made that only through a detailed comparison of mutational mechanisms underlying the evolution of the genetic systems governing development, can the 'logic' of individual development be fully comprehended. To do this, it is essential to choose two or more genes (or their products) that interact in the establishment of a given function, and to compare the molecular basis of that interaction in closely related species. The rationale to this approach arises from observations of molecular co‐evolution (...) between interacting partners involved with given functions which have led to species specificity in the manner in which such functions are effected. Molecular coevolution reveals that divergence in sequence can be tolerated whilst biological functions are maintained, not because it is neutral and dispensable but because successful, compensatory changes can evolve in eukaryotic genomes that are in continuous states of flux. (shrink)

It seems to me that not enough consideration has been given to the fundamental importance of the conditioning to which our physical as well as our mental being have been submitted due to the fact that they develop within a certain gravitational field. All the long evolution of the species seems to proceed from our desire for the impossible abolition of our own gravity, or at least for its partial alleviation. Many centuries before the appearance of man compensatory (...) means were tried and adopted, ranging from the acquatic bladder to the wing and including the simple hopping of the marsupials. (shrink)

Pioneering molecular work on chelicerate visual system development in the horseshoe crabLimulus polyphemussurprised with the possibility that this process may not depend on the deeply conserved retinal determination function ofPax6transcription factors. Genomic, transcriptomic, and developmental studies in spiders now reveal that the arthropodPax6homologseyelessandtwin of eyelessact as ancestral determinants of the ocular head segment in chelicerates, which clarifies deep gene regulatory and structural homologies and recommends more unified terminologies in the comparison of arthropod visual systems. Following this phylotypic stage, chelicerate visual (...) system development differs fundamentally from other arthropods during the compartmentalization of the ocular segment in that eye and optic neuropil primordia originate independently from each other. Comparative analyses of this phase identified further gene regulatory homologies but also major differences, most notably the possibly compensatory replacement ofPax6byPax2in lateral eye specification. Also see the video abstract here:https://youtu.be/Hdfr3z5kEXU. (shrink)

In a series of publications spanning over two decades, William Hasker has argued both that (1) human beings have souls and (2) these souls are not directly created by God but instead are produced by (or “emergent from”) a physical process of some sort or other. By contrast, an alternative view of the human person, endorsed by the contemporary Catholic Church, maintains that (1) human beings have souls but that (2*) each human soul is directly created by God rather than (...) produced by any kind of physical process. Hasker argues that given what we know from evolutionary biology, (2*) is a much less plausible position for believers in souls to take than (2) is. If Hasker is right, then there is a serious tension between the Church’s teaching about the human person and evolutionary biology. In this article, I challenge Hasker’s reasoning. I argue that those who hold the Catholic view that each human soul is directly created by God face no more difficulty reconciling their view with evolutionary biology than those who maintain, as Hasker does, that human souls are instead produced by some kind of physical process. (shrink)

Throughout our entire evolutionary history, the physical environment has played a significant role in shaping humans’ subsistence adaptations. As early humans began to colonise novel biomes and construct ecological niches, their behavioural flexibility appeared as an unquestionable fact. During the Late Pleistocene-Holocene transition, the shift from foraging to farming radically altered ecosystem services, resulting in increased exposure to zoonotic pathogens and the emergence of structural inequalities that pervade our current human condition in the Anthropocene epoch. The article seeks to use (...) an anthropological biosocial analysis to explore the diverse evolutionary paths humans have taken, which in turn shape their relationships with the natural world. Given the enigmatic nature of human behavior, it is essential to examine it holistically to understand how different subsistence patterns (e.g., intensive agriculture, foraging, and horticulture) have influenced resilience and adaptation to environmental challenges. (shrink)

This research aims to reveal the architectural and structural system features by examining the structure of traditional Kahramanmaraş houses and the effect of climate. Within the scope of the research, registered cultural assets in the old neighborhoods of Onikişubat district, which is located in the center of Kahramanmaraş city, will be examined. The research materials constitute old photographs of the city, engravings, and information about the buildings obtained from KUDEB and Kahramanmaraş Metropolitan Municipality units. In light of the information obtained (...) from the materials, visual studies of the buildings were prepared, and the traditional building character of the region was defined. As a result of the findings, it was revealed that the regional climate caused different architectural formations in Kahramanmaraş Traditional Turkish houses and the differences in structural system details. (shrink)

In: B. Hardy-Vallee & N. Payette, eds. Beyond the brain: embodied, situated & distributed cognition. (Cambridge: Cambridge Scholar’s Press), in press. Abstract: In this article, I do three main things: 1. First, I introduce an approach to the mind motivated primarily by evolutionary considerations. I do that by laying out four principles for the study of the mind from an evolutionary perspective, and four predictions that they suggest. This evolutionary perspective is completely compatible with, although broader than, the embodied cognition (...) approach. 2. Then I look at one prediction in depth, the idea that the brain evolved by exaptation–reusing exiting functional units, and combining them in novel ways to generate new cognitive capacities. 3. Finally, I try to lay out some of the implications, both of the in-depth example, and of the more general approach. (shrink)

Le Centre autonome d'enseignement et de pédagogie religieuse (CAEPR) également appelé département de théologie est un département pédagogique de l'UFR de Sciences humaines et sociales de l'université de Lorraine situé à Metz. Les particularités statutaires du CAEPR découlent d’une convention du 25 mai 1974 conclue entre le Saint-Siège et la République française. Elle fixe les prérogatives de l’évêque de Metz dans le fonctionnement de ce département notamment pour la nomination des enseignants chercheurs. L’objectif principal de ce centre est de fournir (...) aux clercs et aux laïcs chargés de l'enseignement religieux catholique dans les écoles primaires et secondaires de la Moselle une formation appropriée. Les autorités religieuses ont de plus sur une longue période demandée aux futurs prêtres de se former dans le cadre du CAEPR. L’évêque de Metz a décidé en 2018 de rompre les liens avec le CAEPER et de mettre fin à la formation universitaire publique des cadres religieux en regrettant que ces formations trop élitistes ne prennent pas en compte les « dimensions humaine, spirituelle et pastorale ». (shrink)

In The Evolution of biological complexity, Christoph Adami, Charles Ofria and Travis C. Collier analysed the relationship between evolution by natural selection and the entropy of the genome. There are some similarities between their paper and my own analysis of.

If there is a common theme through the rich diversity of Max Charlesworth’s academic life and works, it is the quest to understand human action as meaningful, significant and subject to interpretation rather than reducible to the explanatory techniques of positivistic science. This orientation is summed up in the philosophical concept of intentionality. Intentionality is a key notion for continental philosophers whose ideas formed the subject-matter of Max’s legendary course in ‘Contemporary European Philosophy’ at Melbourne University and later, of the (...) foundation philosophy programs at Deakin University. The origins of the concept of intentionality are to be found in mediaeval philosophy – another of Max’s teaching areas, and a commitment to intentionality is deeply implicit in his engagement with the religious and the spiritual as well as with ethics.In this essay I trace the changing conceptions of intentionality in recent philosophy and in doing so, indicate developments within the continental philosophical tradition and its shifting relations with the analytical tradition in Australian philosophy. (shrink)

Translated from Arabic, the novels June Rain by Jabbour Douaihy and Dear Mister Kawabata by Rachid El-Daïf constitute a written testimony that allows us to discover the cultural heritage of the Lebanese village Zgharta. The novel of Douaihy is inspired from a historical fact, the massacre of Miziara which has happened in a church. The heroic abaday myth glorified and dethroned at the same time emerges in an authentic context in Juin Rain. However, Douaihy represents a positive divine figure which (...) incarnates the revolt against violence in a holy space. This heroic world is devalorized by the exogenous westernized vision. In fact, El-Daïf denounces violence that he associates to ignorance, rejection of modernization that he links to the resistance of a divine figure in the collective conscience of the villagers. (shrink)

Clark & Thornton argue that the recoding functions which are used to solve type-2 problems are, at least in part, the ontogenetic products of general-purpose mechanisms. This commentary disputes this and suggests that recoding functions are adaptive specializations.

A and B in signaling games (Lewis 1969). Members of the population, such as our prehistoric pair, are occasionally faced with the following ‘game’. Let one of the players be the receiver and the other the sender. The receiver needs to know whether B is true or not, but only possesses information about whether A is true or not. In some environmental contexts, A is sufficient for B, in others it is not. The sender knows nothing about A or B, (...) but does know that A is sufficient for B in some environments. This is a higher-order signaling game in which both players can benefit from sharing the information that they possess. How does a communication strategy evolve, and is it evolutionarily stable? (shrink)

Aboitiz et al. describe a hypothesis on the origin of the isocortex. They propose the reptilian dorsal cortex to be the ancestral brain structure to the mammalian isocortex. But why did the dorsal cortex expand in mammals and not in reptiles? A change in development may have provided the mammalian cortex with the ability to organize and therefore the potential to expand.