Transcription is a potential threat to genome integrity, and transcription‐associated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and for cells to transmit their genome intact into progeny. For a wide range of structurally diverse DNA lesions, cells employ the highly conserved nucleotide excision repair (NER) pathway to restore their genome back to its native form. Recent evidence suggests that NER factors function, in addition to the canonical DNA repair mechanism, in processes that facilitate mRNA synthesis or (...) shape the 3D chromatin architecture. Here, these findings are critically discussed and a working model that explains the puzzling clinical heterogeneity of NER syndromes highlighting the relevance of physiological, transcription‐associated DNA damage to mammalian development and disease is proposed. (shrink)

(1996). Different concepts and types of nationalism in the Nineteenth and Twentieth centuries. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 453-458.

Unchosen transformative experiences—transformative experiences that are imposed upon an agent by external circumstances—present a fundamental problem for agency: how does one act intentionally in circumstances that transform oneself as an agent, and that disrupt one’s core projects, cares, or goals? Drawing from William James’s analysis of conversion and Matthew Ratcliffe’s account of grief, I give a phenomenological analysis of transformative experiences as involving the restructuring of systems of practical meaning. On this analysis, an agent’s experience of the world is structured (...) by practically significant possibilities that form organized systems on the basis of the agent’s projects and relationships. Transformative experiences involve shifts to systems of possibility, that is, changes to habitual meanings and to how an agent’s projects are situated in relation to one another. I employ the enactivist notion of sense-making to analyze how an agent rebuilds the meaning structures disrupted by a transformative experience. In an unchosen transformative experience, an agent adjusts to a significant disruption through a process of sense-making in precarious conditions. By establishing new patterns of bodily and social interaction with the world, one alters the practical meanings of one’s surroundings, and thereby reconstitutes oneself as an intentional agent. (shrink)

A necessary first step in collaboration between hypnosis research and meditation research is clarification of key concepts. The authors propose that such clarification is best advanced by neurophenomenological investigations that integrate neuroscience methods with phenomenological models based on first-person reports of hypnotic versus meditative experiences. Focusing on absorption, the authors argue that previous treatments of hypnosis and meditation as equivalent are incorrect, but that they can be fruitfully compared when characteristic features of the states described by these concepts are examined. (...) To this end, the authors use the “phenomenological and neurocognitive matrix of mindfulness” (PNM), a multidimensional model recently proposed by Lutz and colleagues. The authors compare focused attention meditation and open monitoring meditation with hypnosis across the dimensions of the PNM, using it to interpret empirical research on hypnosis, and to shed light on debates about the role of meta-awareness in hypnosis and the role of suggestion in meditation. (shrink)

The present study aims to identify contextual and psychological factors of proneness to radicalization and violent extremism operationalized through the Militant Extremist Mindset scale consisting of three distinct aspects: Proviolence, Vile World beliefs, and trust in Divine Power. A community sample of 271 high school students from Belgrade and Sandžak regions in Serbia completed: a 24-item MEM scale; contextual measures including a 6-item scale of family dysfunction and a 4-item composite measure capturing exposure to a harsh school environment and peer (...) abuse ; psychological measures including the 9-item Right-Wing Authoritarianism scale, the 5-item Social Dominance Orientation scale, and the 20-item UCLA Loneliness scale. A path analysis was conducted with contextual factors on the first and psychological factors on the second level of the model predicting the three factors of MEM. LON was positively predicted by FDys and HSE, SDO by HSE only, while RWA was positively predicted by FDys only. Contextual and psychological factors accounted for 27% of the variance in PV, 15% of the variance in VW, and 31% of the variance in DP. Obtained findings reveal a complex interplay of contextual and psychological drivers in the prediction of different aspects of RVE and build upon existing knowledge on risk factors associated with RVE. (shrink)

Монография отражает лингвистический поворот в философии XX века. Особое внимание уделяется невербальным формам коммуникации, предлагается техника анализа таких медиумов, как образы и звуки, тело, лицо, жилище, еда и другие. Для специалистов.

Based on the understanding of the term rhetoric that transcends the notion of literary genre, this book offers new answers to the questions of the provenance and the role of the main rhetorical strategies in Lucretius' De rerum natura.

Anxiety disorders are among the most prevalent mental disorders. Present treatments such as cognitive behavior therapy and pharmacological treatments show only moderate success, which emphasizes the importance for the development of new treatment protocols. Non-invasive brain stimulation methods such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation have been probed as therapeutic option for anxiety disorders in recent years. Mechanistic information about their mode of action, and most efficient protocols is however limited. Here the fear extinction model can (...) serve as a model of exposure therapies for studying therapeutic mechanisms, and development of appropriate intervention protocols. We systematically reviewed 30 research articles that investigated the impact of rTMS and tDCS on fear memory and extinction in animal models and humans, in clinical and healthy populations. The results of these studies suggest that tDCS and rTMS can be efficient methods to modulate fear memory and extinction. Furthermore, excitability-enhancing stimulation applied over the vmPFC showed the strongest potential to enhance fear extinction. We further discuss factors that determine the efficacy of rTMS and tDCS in the context of the fear extinction model and provide future directions to optimize parameters and protocols of stimulation for research and treatment. (shrink)

In this paper we argue that predictive processing (PP) theory cannot account for the phenomenon of affect-biased attention prioritized attention to stimuli that are affectively salient because of their associations with reward or punishment. Specifically, the PP hypothesis that selective attention can be analyzed in terms of the optimization of precision expectations cannot accommodate affect-biased attention; affectively salient stimuli can capture our attention even when precision expectations are low. We review the prospects of three recent attempts to accommodate affect with (...) tools internal to PP theory: Miller and Clark’s (2018) embodied inference; Seth’s (2013) interoceptive inference; and Joffily and Coricelli’s (2013) rate of change of free energy. In each case we argue that the account does not resolve the challenge from affect-biased attention. For this reason, we conclude that prediction error minimization is not sufficient to explain all mental phenomena, contrary to the claim that the PP framework provides a unified theory of all mental phenomena or the brain ‘s cognitive functioning. Nevertheless, we suggest that empirical investigation of the interaction between affective salience and precision expectations should prove helpful in understanding the limits of PP theory, and may provide new directions for the application of a Bayesian perspective to perception. (shrink)

In the past few decades, a growth in ethical consumerism has led brands to increasingly develop conscientiousness and depict ethical image at a corporate level. However, most of the research studying business ethics in the field of corporate brand management is either conceptual or has been empirically conducted in relation to goods/products contexts. This is surprising because corporate brands are more relevant in services contexts, because of the distinct nature of services and the key role that employees have in the (...) services sector. Accordingly, this article aims at empirically examining the effects of customer perceived ethicality in the context of corporate services brands. Based on data collected for eight service categories using a panel of 2179 customers, the hypothesized structural model is tested using path analysis. The results show that, in addition to a direct effect, customer perceived ethicality has a positive and indirect effect on customer loyalty, through the mediators of customer affective commitment and customer perceived quality. Further, employee empathy positively influences the impact of customer perceived ethicality on customer affective commitment, and customer loyalty positively impacts customer positive word-of-mouth. The first implication of these results is that corporate brand strategy needs to be aligned with human resources policies and practices if brands want to turn ethical strategies into employee behavior. Second, corporate brands should build more authentic communications grounded in their ethical beliefs and supported by evidence from actual employees. (shrink)