This paper aims to analyze R. G. Collingwood’s maiden work in philosophy, Religion and Philosophy, in the light of the realism/idealism dispute in early twentieth-century British philosophy. Due to scholars’ narrow scopes of interests, this book has suffered divided and unsettled understandings in literature that find only either realist or idealist character in it. By contrast, I comprehensively examine various aspects of the work on which both readings rest in turn—his conception of history and metaphysics. Consequently, I find out that (...) Collingwood implicitly elaborates a series of negative doctrines attempting to overcome dualismspervading at both poles of the dispute, namely abstract/concrete, subject/object, and theory/action. Since this framework is to be more explicitly present in his subsequent philosophizing, I demonstrate that Religion and Philosophy was, against its underestimated status in literature, not mere juvenilia, but a substantialstarting-point for Collingwood’s philosophy constructively grounded in the contemporary debate. (shrink)

In spite of the evident centrality of philosophical 'realism' in Collingwood's autobiographical account of his own intellectual development, his critique of 'realism' has hardly been investigated as a central theme in his philosophy. Collingwood's arguments against contemporary 'realism' and his stated move beyond 'idealism' have mostly been treated as a minor question subordinate to other questions. By contrast, I have tried in this thesis to reconstruct Collingwood's philosophy as a critical development of the realism/idealism dispute of his day, focusing on (...) his less known early published and unpublished philosophical writings. This has enabled me to clarify his unique definition of 'realism' in terms of a dualistic framework, and understand his philosophy as an attempt to overcome such dualisms in the realms of philosophy. This approach ultimately highlighted the aim of Collingwood's reform of philosophy as the better understanding of the human mind and action. By employing the 'historical' and 'internal' method of analysis, I firstly illustrated how the idea of 'dualism' became an issue in the realism/idealism dispute as it emerged in early twentieth-century British philosophy. This was followed by a biographical sketch in which I demonstrated that Collingwood's educational background was perfectly equipped to refute the 'realist' philosophy in the dispute. Historically contextualising thus, I chronologically restored the formation of his critique of 'realism' as his attempts to synthesise dualisms in logic, ontology, epistemology, and ethics during the period between Religion and Philosophy and An Essay on Philosophical Method. Finally, I argued that Collingwood's critique of 'realism' crystallised in his notion of duty, which embodied his characterisation of philosophy as both 'normative' and 'descriptive'. Throughout, I presented a systematic and sustained picture of Collingwood's early philosophy, identifying and unfolding the fertile implications of his critique of 'realism' for his principal concern with the human mind and action. (shrink)

This study analyzed the effects of aging on post-error behavioral adjustments from the perspective of cognitive control. A modified error awareness task was administered to young and older adults. In this task, two buttons were placed on the left and right sides in front of the participants, who were instructed to use the right button to perform a go/no-go task, and were notified if they made an error. There were three experimental conditions : participants had to push the right button (...) once in Condition A and twice in Condition B and C when a go-stimulus was presented. Conversely, participants were asked to withhold their response when a no-go stimulus was presented. Response inhibition differed depending on the experimental condition. The participants were asked to push the left button as quickly as possible when an error occurred. The results showed relatively longer reaction times to sudden errors among older adults compared with young adults. Furthermore, the difference in the error responses strongly influenced older adults’ response time after an error. These results suggest that the shift from proactive to reactive control may significantly influence post-error behavioral adjustments in older adults. (shrink)

Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. (...) In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID‐19. (shrink)