Gene regulation involves various cis-regulatory elements that can act at a distance. They may physically interact each other or with their target genes to exert their effects. Such interactions are beginning to be uncovered in the imprinted Igf2/H19 domain.1 The differentially methylated regions (DMRs), containing insulators, silencers and activators, were shown to have physical contacts between them. The interactions were changeable depending on their epigenetic state, presumably enabling Igf2 to move between an active and a silent chromatin domain. The study (...) gives us a novel view on how regulatory elements influence gene expression and how epigenetic modifications modulate their long-range effects. (shrink)

What does it mean for the laws of logic to fail? My task in this paper is to answer this question. I use the resources that Routley/Sylvan developed with his collaborators for the semantics of relevant logics to explain a world where the laws of logic fail. I claim that the non-normal worlds that Routley/Sylvan introduced are exactly such worlds. To disambiguate different kinds of impossible worlds, I call such worlds logically impossible worlds. At a logically impossible world, the laws (...) of logic fail. In this paper, I provide a definition of logically impossible worlds. I then show that there is nothing strange about admitting such worlds. (shrink)

Priest holds anti-exceptionalism about logic. That is, he holds that logic, as a theory, does not have any exceptional status in relation to the theories of empirical sciences. Crucial to Priest’s anti-exceptionalism is the existence of ‘data’ that can force the revision of logical theory. He claims that classical logic is inadequate to the available data and, thus, needs to be revised. But what kind of data can overturn classical logic? Priest claims that the data is our intuitions about the (...) validity of inferences. In order to make sense of this claim, I will appeal to the Madhyamaka Buddhist philosopher Candrakīrti. I will then pose a problem for Priest’s anti-exceptionalism. Finally, I will suggest a way out of the problem for Priest. Whether or not he accepts my solution, I will let him decide. (shrink)

Kripke completeness of some infinitary predicate modal logics is presented. More precisely, we prove that if a normal modal logic above is -persistent and universal, the infinitary and predicate extension of with BF and BF is Kripke complete, where BF and BF denote the formulas pi pi and x x, respectively. The results include the completeness of extensions of standard modal logics such as , and its extensions by the schemata T, B, 4, 5, D, and their combinations. The proof (...) is obtained by extending the correspondence between the representation of modal algebras and the completeness of propositional modal logic to infinite. (shrink)

An assessment of mood or emotion is important in developing mental health measures, and facial expressions are strongly related to mood or emotion. This study thus aimed to examine the relationship between levels of negative mood and characteristics of mouth parts when moods are drawn as facial expressions on a common platform. A cross-sectional study of Japanese college freshmen was conducted, and 1,068 valid responses were analyzed. The questionnaire survey consisted of participants’ characteristics, the Profile of Mood States, and a (...) sheet of facial expression drawing, and the sheet was digitized and analyzed using an image-analysis software. Based on the total POMS score as an index of negative mood, the participants were divided into four groups: low, normal, high, and very high. Lengths of drawn lines and between both mouth corners were significantly longer, and circularity and roundness were significantly higher in the L group. With increasing levels of negative mood, significant decreasing trends were observed in these lengths. Convex downward and enclosed figures were significantly predominant in the L group, while convex upward figures were significantly predominant and a tendency toward predominance of no drawn mouths or line figures was found in the H and VH groups. Our results suggest that mood states can be significantly related to the size and figure characteristics of drawn mouths of FACED on a non-verbal common platform. That is, these findings mean that subjects with low negative mood may draw a greater and rounder mouth and figures that may be enclosed and downward convex, while subjects with a high negative mood may not draw the line, or if any, may draw the line shorter and upward convex. (shrink)

The paper is concerned with John Searle’s famous Chinese room argument. Despite being objected to by some, Searle’s Chinese room argument appears very appealing. This is because Searle’s argument is based on an intuition about the mind that ‘we’ all seem to share. Ironically, however, Chinese philosophers don’t seem to share this same intuition. The paper begins by first analysing Searle’s Chinee room argument. It then introduces what can be seen as the (implicit) Chinese view of the mind. Lastly, it (...) demonstrates a conceptual difference between Chinese and Western philosophy with respect to the notion of mind. Thus, it is shown that one must carefully attend to the presuppositions underlying Chinese philosophising in interpreting Chinese philosophers. (shrink)

There was a time when 'logic' just meant classical logic. The climate is slowly changing and non-classical logic cannot be dismissed off-hand. However, a metatheory used to study the properties of non-classical logic is often classical. In this paper, we will argue that this practice of relying on classical metatheories is problematic. In particular, we will show that it is a bad practice because the metatheory that is used to study a non-classical logic often rules out the very logic it (...) is designed to study. (shrink)

In 1A:7 of the Mengzi, Mengzi tries to convince King Xuan of Qi that he is a “true” king. As a reading of Mengzi’s reasoning involved in his attempt at persuasion, David Nivison advances an inferential view, according to which Mengzi’s persuasion involves inferences. In this paper, I consider the assumptions underlying the objections raised against Nivison’s inferential view. I argue that these objections assume a contemporary Western view about the nature of logic and inferences. I propose an alternative characterisation (...) of the relevant sense of inference that, I believe, is more sensitive to the classical Chinese philosophical context and argue that certain insights can be derived from reading Mengzi in light of this alternative characterization of inferences. (shrink)

BackgroundRegulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other countries are relatively unaware of these due to the language barrier. This article aims to describe and compare the relevant regulatory frameworks, using the (more familiar) situation in England as a point of reference. We undertook literature reviews to ascertain the legal and regulatory positions on forgoing LST in Japan, Korea, Taiwan, and England.Main textFindings from a literature review are first presented to (...) describe the development of the regulatory frameworks surrounding the option of forgoing LST in each country. Based on the findings from the four countries, we suggest five ethically important points, reflection on which should help to inform the further development of regulatory frameworks concerning end-of-life care in these countries and beyond. There should be reflection on: (1) the definition of – and reasons for defining – the ‘terminal stage’ and associated criteria for making such judgements; Korea and Taiwan limit forgoing LST to patients in this stage, but there are risks associated with defining this too narrowly or broadly; (2) foregoing LST for patients who arenotin this stage, as is allowed in Japan and England, because here too there are areas of controversy, including (in England) whether the law in this area does enough to respect the autonomy of (now) incapacitated patients; (3) whether ‘foregoing’ LST should encompass withholdingandwithdrawing treatment; this is also an ethically disputed area, particularly in the Asian countries we examine; (4) the family’s role in end-of-life decision-making, particularly as, compared with England, the three Asian countries traditionally place a greater emphasis on families and communities than on individuals; and (5) decision-making with and for those incapacitated patients who lack families, surrogate decision-makers or ADs.ConclusionComparison of, and reflection on, the different legal positions that obtain in Japan, Korea, Taiwan, and England should prove informative and we particularly invite reflection on five areas, in the hope the ensuing discussions will help to establish better end-of-life regulatory frameworks in these countries and elsewhere. (shrink)

Narrative views of the self argue that we constitute our self in self-narratives. Embodied views hold that our self is shaped through embodied experiences. In that case, what is the relation between embodiment and narrativity in the process of self-constitution? The question demands a clear definition of embodiment, but existing studies remains unclear on this point (section 2). We offer a correction to this situation by drawing on Merleau-Ponty’s analysis of the body that highlights its habituality. On this account, the (...) body has an inherent tendency to cultivate an organization of habits through its history of engagement with the world (section 3). Next, we explore its role in narrative self-constitution by distinguishing between two aspects of the narrative self, the narrated I and the narrating I (section 4). We argue on phenomenological grounds that self-narratives are informed by bodily perspectives in both respects. Furthermore, a focus on the habituality of the body allows for a better explanation of self-constitution than those based on implicit self-narratives (section 5). For these phenomenological and theoretical reasons, we conclude that narrative self-constitution is an embodied and embedded practice (section 6). (shrink)

Toyoichi Tanaka's pioneering work in biophysics made major contributions to the science of gels and polymers. His research centered on the physics of gels, their fundamental structures and characteristics, their dynamics, and their roles in living organisms. This volume collects twenty-five major research papers originally published in Science, Nature, Physical Review Letters, and other leading journals between 1973 and 2000. The English texts are supplemented with Japanese summaries and critiques written by a group of Dr. Tanaka's colleagues and (...) students. (shrink)

In this paper, we show within RCA 0 that weak Konig's lemma is necessary and sufficient to prove that any (separable) compact group has a Haar measure. Within WKL 0 , a Haar measure is constructed by a non-standard method based on a fact that every countable non-standard model of WKL 0 has a proper initial part isomorphic to itself [10].

Wright’s “adaptive landscape” has been influential in evolutionary thinking but controversial, especially because the landscape that organisms encounter is altered by the evolutionary process itsel...

Logic in Buddhist Philosophy concerns the systematic study of anumāna (often translated as inference) as developed by Dignāga (480-540 c.e.) and Dharmakīti (600-660 c.e.). Buddhist logicians think of inference as an instrument of knowledge (pramāṇa) and, thus, logic is considered to constitute part of epistemology in the Buddhist tradition. According to the prevalent 20th and early 21st century ‘Western’ conception of logic, however, logical study is the formal study of arguments. If we understand the nature of logic to be formal, (...) it is difficult to see what bearing logic has on knowledge. In this paper, by weaving together the main threads of thought that are salient in Dignāga’s and Dharmakīti’s texts, I shall re-conceive the nature of logic in the context of epistemology and demarcate the logical part of epistemology which can be recognised as logic. I shall demonstrate that we can recognise the logical significance of inference as understood by Buddhist logicians despite the fact that its logical significance lies within the context of knowledge. (shrink)

Fuzzy logic has become an important tool for a number of different applications ranging from the control of engineering systems to artificial intelligence. In this concise introduction, the author presents a succinct guide to the basic ideas of fuzzy logic, fuzzy sets, fuzzy relations, and fuzzy reasoning, and shows how they may be applied. The book culminates in a chapter which describes fuzzy logic control: the design of intelligent control systems using fuzzy if-then rules which make use of human knowledge (...) and experience to behave in a manner similar to a human controller. Throughout, the level of mathematical knowledge required is kept basic and the concepts are illustrated with numerous diagrams to aid in comprehension. As a result, all those curious to know more about fuzzy concepts and their real-world application will find this a good place to start. (shrink)