The autophagy initiation complex is brought about via a highly ordered and stepwise assembly process. Two crucial signaling molecules, mTORC1 and AMPK, orchestrate this assembly by phosphorylating/dephosphorylating autophagy‐related proteins. Activation of Atg1 followed by recruitment of both Atg9 vesicles and the PI3K complex I to the PAS (phagophore assembly site) are particularly crucial steps in its formation. Ypt1, a small Rab GTPase in yeast cells, also plays an essential role in the formation of the autophagy initiation complex through multiple regulatory (...) pathways. In this review, our primary focus is to discuss how signaling molecules initiate the assembly of the autophagy initiation complex, and highlight the significant roles of Ypt1 in this process. We end by addressing issues that need future clarification. (shrink)

The problem of revolutionary subjects has always been a core problem within Marxist philosophy. In the classical Marxist philosophy, the revolutionary subject is naturally endowed with the working class, and the working class was identified as the bourgeois gravedigger. However, in the post-war capitalist society, the working class’s living conditions greatly improved, forcing many Marxists to rethink the revolutionary subject. Many studies on the subject of revolution have emerged. The aim of this research is to sort out these theories and (...) conduct a systematic study. (shrink)

This paper explores how to explain the applicability of classical mathematics to the physical world in a radically naturalistic and nominalistic philosophy of mathematics. The applicability claim is first formulated as an ordinary scientific assertion about natural regularity in a class of natural phenomena and then turned into a logical problem by some scientific simplification and abstraction. I argue that there are some genuine logical puzzles regarding applicability and no current philosophy of mathematics has resolved these puzzles. Then I introduce (...) a plan for resolving the logical puzzles of applicability. (shrink)

The problem of Confucius has been the subject of a most heated debate in philosophy circles for several years. Prior to 1962, the major points of debate were: whether the philosophical thought of Confucius is idealistic or materialistic; whether the political thought of Confucius represents [the interests of] the ruined slaveholders or the newly emerged landlord class; and whether the thoughts of Confucius are reactionary or progressive. However, since the spring of 1962 a new trend began to appear. Articles glorifying (...) Confucius began to appear in the press throughout the country. They dealt with Confucian ideas on a profusion of subjects, such as arts, music, military affairs, psychology, and so forth. Some of these articles presented an abstract analysis of Confucian thoughts as transcending all classes and times and made them eternal and "evergreen"; some went as far as to put Marxist ideology under the name of Confucius. Others maintained that we should treasure Confucian thoughts and that any criticism would ruin the legacy. Still others asserted that the policy of treasuring legacy of the Confucian thoughts should be "arrangement, consolidation, and elevation.". (shrink)

本书共三章,内容包括:儒者关怀的宏观定位——对佛老之学的批判反思、个体生命的意义安置——修养学说的形成和发展、社会理想的执着追求——改造现实的理论与实践。.

This article attempts to motivate a new approach to anti-realism (or nominalism) in the philosophy of mathematics. I will explore the strongest challenges to anti-realism, based on sympathetic interpretations of our intuitions that appear to support realism. I will argue that the current anti-realistic philosophies have not yet met these challenges, and that is why they cannot convince realists. Then, I will introduce a research project for a new, truly naturalistic, and completely scientific approach to philosophy of mathematics. It belongs (...) to anti-realism, but can meet those challenges and can perhaps convince some realists, at least those who are also naturalists. (shrink)

There are three major theses in Plantinga’s latest version of his evolutionary argument against naturalism. (1) Given materialism, the conditional probability of the reliability of human cognitive mechanisms produced by evolution is low; (2) the same conditional probability given reductive or non-reductive materialism is still low; (3) the most popular naturalistic theories of content and truth are not admissible for naturalism. I argue that Plantinga’s argument for (1) presupposes an anti-materialistic conception of content, and it therefore begs the question against (...) materialism. To argue for (2), Plantinga claims that the adaptiveness of a belief is indifferent to its truth. I argue that this claim is unsupported unless it again assumes an anti-materialistic conception of content and truth. I further argue that Plantinga’s argument for (3) is not successful either, because an improved version of teleosemantics can meet his criticisms. Moreover, this version of teleosemantics implies that the truth of a belief is (probabilistically) positively related to its adaptiveness, at least for simple beliefs about physical objects in human environments. This directly challenges Plantinga’s claim that adaptiveness is indifferent to truth. (shrink)

In fear differential conditioning, stimuli that resemble the conditioned stimulus (CS+) are more likely to trigger fear responses. Excessive fear responses on stimuli not like CS + are often associated with anxiety. However, the threat judgments process and how this process manifests itself differently in subgroups with different generalisation rule applications, is unclear. This study examines whether anxiety biases the threat decision process in fear generalisation paradigm and whether subgroups characterised by different generalisation gradients was interpreted differently by drift-diffusion model. (...) We gathered behavioural data through a binary fear generalisation judgment task and clustered participants based on their responses. Reaction time distributions and individual scale scores were analyzed using the hierarchical drift-diffusion model. The model results suggested that similarity and state anxiety facilitated evidence-gathering processes that favoured “threat” judgments, but at the same time, state anxiety weakened the effect of stimulus similarity as evidence. Further cluster analyses revealed that this effect of anxiety on threat judgments only held true for specific subgroups of participants. This pioneering computational modelling effort in fear generalisation underscores the significant role of strategy preference and its complex interaction with anxiety in shaping stimulus processing. (shrink)

During the COVID-19 pandemic, online health platforms and physicians’ online knowledge sharing played an important role in public health crisis management and disease prevention. What influences physicians’ online knowledge sharing? From the psychological perspective of stimulus–response, this study aims to explore how patients’ visit and patients’ consultation influence physicians’ online knowledge sharing considering the contingent roles of physicians’ online expertise and online knowledge sharing experience. Based on 6-month panel data of 45,449 physician–month observations from an online health platform in China, (...) the results indicate that both patients’ visit and patients’ consultation are positive related to physicians’ online knowledge sharing. Online expertise weakens the positive effect of patients’ consultation on physicians’ online knowledge sharing. Online knowledge sharing experience weakens the positive relationship between visit of patient and physicians’ online knowledge sharing, and enhances the positive relationship between patients’ consultation and physicians’ online knowledge sharing. This study contributes to the literatures about stimulus–response in psychology and knowledge sharing, and provides implications for practice. (shrink)

The wanton dissemination of network pseudohealth information has brought great harm to people’s health, life, and property. It is important to detect and identify network pseudohealth information. Based on this, this paper defines the concepts of pseudohealth information, data block, and data block integration, designs an architecture that combines the latent Dirichlet allocation algorithm and data block update integration, and proposes the combination algorithm model. In addition, crawler technology is used to crawl the pseudohealth information transmitted on the Sina Weibo (...) platform during the “epidemic situation” from February to March 2020 for the simulation test on the experimental case dataset. The research results show that the LDA model can deeply mine the semantic information of network pseudohealth information, obtain the features of document-topic distribution, and classify and train topic features as input variables; the dataset partitioning method can effectively block data according to the text attributes and class labels of network pseudohealth information and can accurately classify and integrate the block data through the data block reintegration method; and considering that the combination model has certain limitations on the detection of network pseudohealth information, the support vector machine model can extract the granularity content of data blocks in pseudohealth information in real time, thus greatly improving the recognition performance of the combination model. (shrink)

The Kripkean metaphysical modality (i.e. possibility and necessity) is one of the most important concepts in contemporary analytic philosophy and is the basis of many metaphysical speculations. These metaphysical speculations frequently commit to entities that do not belong to this physical universe, such as merely possible entities, abstract entities, mental entities or qualities not realizable by the physical, which seems to contradict naturalism or physicalism. This paper proposes a naturalistic interpretation of the Kripkean modality, as a naturalist’s response to these (...) metaphysical speculations. It will show that naturalism can accommodate the Kripkean metaphysical modality. In particular, it will show that naturalism can help to resolve the puzzles surrounding Kripke’s a posteriori necessary propositions and a priori contingent propositions. (shrink)

This is a philosophical book about the idea of human freedom in the context of Chinese philosophy on truth, the good, and beauty. The book shows that there is a coherent and sophisticated philosophical discourse on human freedom throughout the history of Chinese Philosophy in aesthetics, ethics, and epistemology. Feng Qi discusses the development of freedom in light of the Marxist theory of practice. In the history of philosophy, the relation between thought and existence, which is fundamental to philosophy, (...) has stimulated many debates. These debates, though they have assumed diverse forms in Chinese and Western philosophy, have eventually concentrated on three inquiries: the natural world (the objective material world); the human mind; and the concepts, categories, and laws that are representative forms of nature in the human mind and in knowledge. In Chinese philosophy, the three inquiries are summarized using three notions: qi (气 breath, spirit), xin (心 heart), dao (道 the Way). What relationship do the three notions have with each other? This book explores the way to human freedom through the divergent paths in Chinese philosophy. This book’s investigation of human activities brings the typical Chinese philosophical discourse from the cosmological realm into the realm of human beings as individuals. In this regard, the three inquiries can be described as being about real life, ideals, and individuals. (shrink)

In this work we report a simple way to measure the similarity between two nucleotide sequences by using graph theory and information theory. This method reported allows for theoretical comparisons of naturally occurring nucleotide sequences.

This essay explores the nature of absorbed experience which occurs when we are deeply immersed in a practical activity, such as when we make a work of art. This absorption is at the heart of all concentrated activity and reinforces those moments of engaged creativity when self-consciousness is freed from the calculations of the ego. Such occasions cannot be willed or predicted, but rather appear to arise spontaneously as in a stream of consciousness in which there is recognisable flow that (...) is undisrupted by language. Indeed, there is evidence that in these engaged moments, language itself is held in abeyance and that embodied activity takes over as we lose ourselves in the practical experience of making. Both the literature and artists’ accounts of their practice have tended to overlook the nature of these experiences. (shrink)

Concerns with improper collection and usage of personal information by businesses or governments have been seen as critical to the success of the emerging electronic commerce. In this regard, computer professionals have the oversight responsibility for information privacy because they have the most extensive knowledge of their organization's systems and programs, as well as an intimate understanding of the data. Thus, the competence of these professionals in ensuring sound practice of information privacy is of great importance to both researchers and (...) practitioners. This research addresses the question of whether male computer professionals differ from their female counterparts in their self-regulatory efficacy to protect personal information privacy. A total of 103 male and 65 female subjects surveyed in Taiwan responded to a 10-item questionnaire that includes three measures: protection, non-distribution, and non-acquisition. The findings show significant gender differences exist in the subjects' overall self-regulatory efficacy for information privacy, and, in particular, that female subjects in this study exhibited a higher level of self-regulatory efficacy than males for the protection and non-acquisition of personal privacy information. The identification of the factorial structure of the self-regulatory efficacy concerning information privacy may contribute to future research directed to examining the links between privacy efficacy and psychological variables, such as ethical attitude, ethical intention, and self-esteem. Studies can also be extended to investigate how different cultural practices of morality and computer use in men and women may shape the different development patterns of privacy self-efficacy. Understanding the different cultural practices may then shed light on the social sources of privacy competence and the appropriate remedies that can be provided to improve the situation. (shrink)

I argue that the most popular versions of naturalism imply nominalism in philosophy of mathematics. In particular, there is a conflict in Quine's philosophy between naturalism and realism in mathematics. The argument starts from a consequence of naturalism on the nature of human cognitive subjects, physicalism about cognitive subjects, and concludes that this implies a version of nominalism, which I will carefully characterize. The indispensability of classical mathematics for the sciences and semantic/confirmation holism does not affect the argument. The disquotational (...) theory of reference and truth is discussed but rejected. This argument differs from the Benacerrafian arguments against realism, because it does not rely on any specific assumption about the nature of knowledge or reference. It differs from the popular objections to the indispensability argument for realism as well, because it can admit both indispensability and holism. This argument motivates a new, radically naturalistic and nominalistic approach to philosophy of mathematics. (shrink)

We show that the following results in the classical theory of unbounded linear operators on Hilbert spaces can be proved within the framework of Bishop's constructive mathematics: the Kato-Rellich theorem, the spectral theorem, Stone's theorem, and the self-adjointness of the most common quantum mechanical operators, including the Hamiltonians of electro-magnetic fields with some general forms of potentials.

本书主要是对朱陈书信的逐段义疏，义疏的方式包括对字句文脉的梳理、义理的阐发、朱陈其他相关书信文章语录的旁证、已有研究的回应以及作者案语总结，试图兼顾考据、辞章、义理以及前人研究，结语部分归纳双方论点， 并对某些问题略发余论。.

It is not only difficult to be a sports expert but also difficult to grow from a sports expert to a sports elite. Professional athletes are often concerned about the differences between an expert and an elite and how to eventually become an elite athlete. To explore the differences in brain neural mechanism between experts and elites in the process of motor behavior and reveal the internal connection between motor performance and brain activity, we collected and analyzed the electroencephalography findings (...) of 14 national archers and 14 provincial archers during aiming and resting states and constructed the EEG brain network of the two archer groups based on weighted phase lag index; the graph theory was used to analyze and compare the network characteristics via local network and global network topologies. The results showed that compared with the expert archers, the elite archers had stronger functional coupling in beta1 and beta2 bands, and the difference was evident in the frontal and central regions; in terms of global characteristics of brain network topology, the average clustering coefficient and global efficiency of elite archers were significantly higher than that of expert archers, and the eigenvector centrality of expert archers was higher; for local characteristics, elite archers had higher local efficient; and the brain network characteristics of expert archers showed a strong correlation with archery performance. This suggests that compared with expert archers, elite archers showed stronger functional coupling, higher integration efficiency of global and local information, and more independent performance in the archery process. These findings reveal the differences in brain electrical network topologies between elite and expert archers in the archery preparation stage, which is expected to provide theoretical reference for further training and promotion of professional athletes. (shrink)

Remanufacturing widely exists in production activities. Two different game models are involved while considering reverse channels: In Model P, the manufacturer provides new and remanufactured products to two retailers. New products are sold through an online platform, while remanufactured products are sold in offline physical stores in a decentralized scenario. In Model C, the manufacturer provides new and remanufactured units to only one retailer that operates both online and offline channels in a centralized scenario. This research showed that a manufacturer’s (...) profitability and industry profits in Model P were higher than those in Model C from the perspective of economic performance; the sum of the profits of both retailers in Model P was worse than the profits of the retailer in Model C. Moreover, Model P was found to be greener than Model C from the perspective of environmental sustainability. From a social viewpoint, Model P had a higher consumer surplus than Model C; the higher the cost of distributing a remanufactured unit, the more disadvantageous the model to the consumers. (shrink)

苏珊·朗格是西方美学史上迄今为止惟一的一位声名显赫的女性美学家。本书勾勒了朗格的生平,揭示了朗格哲学美学思想演化的内在脉络,阐述了她的符号论思想、生命形式、逻辑类似、艺术幻象等理论。.

In 1923, there was a debate in Chinese philosophical circles on the view of life [also known as the science versus metaphysics controversy]. In the introduction to A View of Life, I described the situation at the time.