The neural crest is a transient population of multipotent progenitors arising at the lateral edge of the neural plate in vertebrate embryos. After delamination and migration from the neuroepithelium, these cells contribute to a diverse array of tissues including neurons, smooth muscle, craniofacial cartilage, bone cells, endocrine cells and pigment cells. Considerable progress in recent years has furthered our understanding at a molecular level of how this important group of cells is generated and how they are assigned to specific lineages. (...) Here we review a number of recent studies supporting a role for Wnt signaling in neural crest induction, differentiation, and apoptosis. We also summarize the timing of expression of a number of Wnt ligands and receptors with respect to neural crest induction. BioEssays 25:317–325, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Twenty-five years ago, when I went down to the countryside to live and work in a production team, I took a few books with me, one of which was Ovid's Metamorphoses. The people in our team looked through it many times, read and reread it, until it was as ragged as a roll of dried seaweed. Then people from other teams borrowed it, and I spotted it in several different places, looking more and more dilapidated. I believe that in the (...) end the book was read to death. Even now I still can't forget what a sorry state it was in. Life in the team was very hard—We didn't have enough to eat, we couldn't get used to the climate, and many people got sick; but the worst hardship of all was that there were no books to read. If we had had a lot of books to read, Metamorphoses would not have disappeared so tragically. On top of this, we never had the pleasure of thought. I do not believe I was alone in this experience: As you sat lonely and forlorn under the eaves in the twilight, and watched the sky slowly darken, you felt that you'd been deprived of your life. I was young then, but I was scared of having to go on living like that, of growing old like that. To my mind, that would be even more frightening than death. (shrink)

For a long time now there have been different interpretations of the philosophical category "one divides into two." The debate that took place in scholarly circles in 1964 over "one divides into two" and "two combine into one" began with the question of how to interpret this category. At first this was a very lively and widespread scholarly debate. But later, because those "authorities on theory" who had at that time taken over the reigns of intellectual leadership within the Party (...) created contemporary superstitions that inhibited thought, the tone and boundaries of this debate became arbitrarily fixed and circumscribed so that this scholarly question became a political issue resulting in the criticism and trial of comrades such as Yang Xianzhen and the premature death of this debate. Today, in accordance with the spirit of the Third Session of the Eleventh Congress of the Central Committee of the Party, with an attitude of really searching for the truth, we must undertake a new and correct evaluation of this debate. Politically, we must overturn the false charges which were wrongly leveled at Comrade Yang Xianzhen and others, and intellectually, we must uphold the policy of "let a hundred schools contend, let a hundred flowers bloom." We must encourage the free discussion of different points of view, and we must avoid issuing hasty conclusions. All of us comrades who participated in this debate should accept the valuable experience and lessons learned from it. We want the debate on this question to truly become a widespread intellectual debate which will once again develop and move forward healthily. In this article I would simply like to talk about a few of my own views concerning the problem of how to correctly interpret "one divides into two.". (shrink)

Compared with traditional technological innovation modes, green technology innovation is more targeted for low carbon development and critical support for countries worldwide to combat climate change. The impact of green technology innovation on carbon emissions is considered in terms of fixed effect and mediating effect models through industrial structure upgrading. For this purpose, the sample dataset of 30 provincial administrative areas in China from 2008 to 2020 is employed. The results demonstrate that green technology innovation exerts significantly inhibitory effects on (...) carbon emissions, whose conclusion still holds after removing municipalities and replacing the dependent variable. Industrial structure upgrading is vital for green technology innovation to diminish carbon emissions. There is significant regional heterogeneity in the effects of green technology innovation on carbon emissions, i.e., the direct and indirect impact of green technology innovation on carbon emission reduction is significant in the eastern-central area, but its effect is insignificant in the western region. Therefore, it is essential to realize carbon emission reduction by further bolstering green technology innovation and accelerating industrial structure upgrading to fulfill the synergy of technology and structure. (shrink)

This paper discusses how a Platform for Philosophy Education can help to alleviate issues of alienation in the lives of university students. This is done through various personal cultivation and community building activities in the Academic Philosophy Café. The activities draw from philosophical traditions, including traditions with religious or “spiritual” elements. These encourage reflection on one’s place in the world. In addition, students and teachers cooperate to ensure the smooth running of the café and activities, which strengthens the community bond. (...) There is thus a “spiritual contract” formed between participants. In contrast to a written contract that binds parties by means of explicit rewards or sanctions, a “spiritual contract” is built on mutual understanding that higher-level needs will be met through the process of cooperation. Based upon this, a community is established that nourishes the lives of those on campus, benefits their wellbeing and strengthens their capacity to learn effectively. (shrink)

ObjectiveThis study aimed to examine the effectiveness and safety of the Brain-computer interface in treatment of upper limb dysfunction after stroke.MethodsEnglish and Chinese electronic databases were searched up to July 2021. Randomized controlled trials were eligible. The methodological quality was assessed using Cochrane’s risk-of-bias tool. Meta-analysis was performed using RevMan 5.4.ResultsA total of 488 patients from 16 RCTs were included. The results showed that the meta-analysis of BCI-combined treatment on the improvement of the upper limb function showed statistical significance [standardized (...) mean difference : 0.53, 95% CI: 0.26–0.80, P < 0.05]; BCI treatment can improve the abilities of daily living of patients after stroke, and the analysis results are statistically significant ; and the BCI-combined therapy was not statistically significant for the analysis of the Modified Ashworth Scale.ConclusionThe meta-analysis indicates that the BCI therapy or BCI combined with other therapies such as conventional rehabilitation training and motor imagery training can improve upper limb dysfunction after stroke and enhance the quality of daily life. (shrink)

Attentional biases have received considerable focus in research on cognitive biases and body dissatisfaction (BD). However, most work has focused on spatial allocation of attention. The current two experiments employed a rapid serial visual presentation (RSVP) task to investigate the temporal allocation of attention to body-related words among young females with high and low BD. Experiment 1 assessed the stimulus-driven attention of body-related stimuli. Participants identified a neutral second target (T2) as accurately as possible while ignoring the preceding neutral, fat-, (...) or thin-related first target (T1). As expected, we observed spontaneous attentional blink effects elicited by fat- and thin-related T1s among participants with high BD, suggesting enhanced awareness of body-related stimuli even when this information does not have to be identified. Such effects did not emerge among participants without BD. Experimental 2 investigated the goal-directed attention of body-related stimuli, during which participants needed to identify both the T1 and neutral T2. Participants with BD showed reduced attentional blink effects after both fat- and thin-related T1, suggesting facilitated consolidation of body-related information in goal-directed attention among participants with BD. The findings may have important clinical implications for understanding how to decrease and even prevent body image dissatisfaction. (shrink)

In this article, we study the mural restoration work based on artificial intelligence-assisted multiscale trace generation. Firstly, we convert the fresco images to colour space to obtain the luminance and chromaticity component images; then we process each component image to enhance the edges of the exfoliated region using high and low hat operations; then we construct a multistructure morphological filter to smooth the noise of the image. Finally, the fused mask image is fused with the original mural to obtain the (...) final calibration result. The fresco is converted to HSV colour space, and chromaticity, saturation, and luminance features are introduced; then the confidence term and data term are used to determine the priority of shedding boundary points; then a new block matching criterion is defined, and the best matching block is obtained to replace the block to be repaired based on the structural similarity between the block to be repaired and the matching block by global search; finally, the restoration result is converted to RGB colour space to obtain the final restoration result. An improved generative adversarial network structure is proposed to address the shortcomings of the existing network structure in mural defect restoration, and the effectiveness of the improved modules of the network is verified. Compared with the existing mural restoration algorithms on the test data experimentally verified, the peak signal-to-noise ratio score is improved by 4% and the structural similarity score is improved by 2%. (shrink)

Academic mothers perform intersected roles. They carry out their profession in workplaces, while they take the “second shift” of motherhood back to their families. The contested expectations in family and career built by the heterosexual matrix cause tension to academic mothers. We qualitatively investigate the interview data of six Chinese women academics on how they perform to negotiate their motherhood and academic work in the context of Chinese higher education, driven by the Butlerian theoretical concept of the heterosexual matrix. The (...) findings suggest that Chinese academic mothers play a zero-sum game between being mothers and being academics, deriving from their ontological responsibilities of motherhood. We conclude that in the masculine academia, these women academics help maintain the heterosexual matrix by satisfying the gender normativity when they negotiate their performances in their family and career; meanwhile, most have developed some strategies to achieve their career advancement. (shrink)

A long-standing problem in biology, economics, and social sciences is to understand the conditions required for the emergence and maintenance of cooperation in evolving populations. This paper investigates how to promote the evolution of cooperation in the Prisoner’s Dilemma game. Differing from previous approaches, we not only propose a tag-based control mechanism but also look at how the evolution of cooperation by TBC can be successfully promoted. The effect of TBC on the evolutionary process of cooperation shows that it can (...) both reduce the payoff of defectors and inhibit defection; although when the cooperation rate is high, TBC will also reduce the payoff of cooperators unless the identified rate of the TBC is large enough. An optimal timing control of switched replicator dynamics is designed to consider the control costs, the cooperation rate at terminal time, and the cooperator’s payoff. The results show that the switching control between an optimal identified rate control of the TBC and no TBC can properly not only maintain a high cooperation rate but also greatly enhance the payoff of the cooperators. Our results provide valuable insights for some clusters, for example, logistics parks and government, to regard the decision to promote cooperation. (shrink)

The aim of cognitive diagnosis is to classify respondents' mastery status of latent attributes from their responses on multiple items. Since respondents may answer some but not all items, item-level missing data often occur. Even if the primary interest is to provide diagnostic classification of respondents, misspecification of missing data mechanism may lead to biased conclusions. This paper proposes a joint cognitive diagnosis modeling of item responses and item-level missing data mechanism. A Bayesian Markov chain Monte Carlo method is developed (...) for model parameter estimation. Our simulation studies examine the parameter recovery under different missing data mechanisms. The parameters could be recovered well with correct use of missing data mechanism for model fit, and missing that is not at random is less sensitive to incorrect use. The Program for International Student Assessment 2015 computer-based mathematics data are applied to demonstrate the practical value of the proposed method. (shrink)

Adenosine‐to‐inosine (A‐to‐I) RNA editing, capable of protein recoding, has evolved independently in animals and fungi. This study proposes adaptive hypotheses regarding its origins and phenotypic significance, suggesting that A‐to‐I editing enhances adaptability by alleviating genetic trade‐offs. In metazoans, its emergence may have been driven by a development‐defense trade‐off associated with transposable element activation during the evolution of multicellularity. Late Devonian cooling and End‐Permian warming are hypothesized to have driven the emergence of extensive A‐to‐I recoding in coleoid nervous systems and Sordariomycete (...) sexual fruiting bodies, respectively. These adaptations may have influenced key evolutionary innovations, including the evolution of metazoan nervous systems, coleoid intelligence, and shell loss, and fungal sexual reproductive structures. Additionally, extensive A‐to‐I recoding is proposed to facilitate accelerated development and specific life‐history strategies in both animals and fungi. This paper provides new perspectives on the evolutionary forces shaping A‐to‐I RNA editing and its role in phenotypic diversity across taxa. (shrink)

Given the significance of teachers’ professional success in the adequacy of education, exploring the determinants of this variable appears crucial. To address this need, this inquiry inspected the role of well-being and emotion regulation in Chinese EFL teachers’ professional success. For this purpose, 357 Chinese EFL teachers were selected to answer three pre-designed questionnaires. Structural equation modeling using Smart-PLS was implemented to analyze teacher participants’ responses. The structural model revealed a strong, favorable connection between well-being, emotion regulation, and professional success. (...) The model also demonstrated that both well-being and emotion regulation were highly influential in Chinese EFL teachers’ professional success. The potential implications for EFL teachers, teacher educators, and educational authorities are further discussed. (shrink)

Actuator saturation phenomenon often exists in the actual control system, which could destroy the closed-loop performance of the system and even lead to unstable behavior. Our main contribution is to provide an antiwindup recursive dynamic surface control for a discrete-time system with an unknown state and actuator saturation. The fuzzy compensator is added to perform as an active disturbance rejection term in the feedforward path to avoid windup caused by input saturation. To construct output feedback control, the system is transformed (...) into the form of pure-feedback and an improved HOSM observer is designed to carry out future output prediction. Based on which RDSC is synthesized, only one fuzzy logic system is used and the controller singularity is completely avoided. In addition, the simulation and numeral examples using a continuous stirred tank reactors system with actuator saturation are provided and the results show that the strategy owns good robustness and effectively compensates for the disturbance caused by actuator saturation in the presence of a discrete-time system with an unmeasurable state. (shrink)

Neurological diseases (NDs), featured by progressive dysfunctions of the nervous system, have become a growing burden for the aging populations. N‐Deacetylase and N‐sulfotransferase 3 (NDST3) is known to catalyze deacetylation and N‐sulfation on disaccharide substrates. Recently, NDST3 is identified as a novel deacetylase for tubulin, and its newly recognized role in modulating microtubule acetylation and lysosomal acidification provides fresh insights into ND therapeutic approaches using NDST3 as a target. Microtubule acetylation and lysosomal acidification have been reported to be critical for (...) activities in neurons, implying that the regulators of these two biological processes, such as the previously known microtubule deacetylases, histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2), could play important roles in various NDs. Aberrant NDST3 expression or tubulin acetylation has been observed in an increasing number of NDs, including amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), schizophrenia and bipolar disorder, Alzheimer's disease (AD), and Parkinson's disease (PD), suggesting that NDST3 is a key player in the pathogenesis of NDs and may serve as a target for development of new treatment of NDs. (shrink)

The emerging discourse of hopeful tourism (Hunter 1997; Lee et al. 2017; Pritchard, Morgan, and Ateljevic 2011; Sampaio, Thomas, and Font 2012; Schultz et al. 2005; Tolkach, Pratt, and Zeng 2017) h...

With the rapid development of renewable generators such as distributed photovoltaic and profound changes of the power structure, this paper analyzes the frequency characteristics of the power system with high penetration of renewable generations in the process of low-frequency load shedding and discusses the influence of the distributed renewable generator frequency endurance capabilities on the implementation effect of low-frequency load shedding in detail. Finally, the influences of the distributed renewable generator frequency endurance capability and the capacities of the distributed renewable (...) generator on frequency response characteristics of an actual Hunan power grid are simulated. The simulation results show that more distributed photovoltaic capacity without frequency endurance capability leads to deeper frequency drops after the disturbance and requires more basic rounds of load shedding. When the penetration rate of distributed photovoltaic is too high, it may cause load shedding, resulting in power grid load losses and, at the same time, leading to an overshoot phenomenon in the process of frequency recovery. Therefore, the influence of distributed photovoltaic on the control of low-frequency load shedding should be considered when designing low-frequency load shedding schemes for the power grid with high penetration of distributed photovoltaic. (shrink)

In order to improve the integrity of the social network behavior feature extraction results for sports college students, this study proposes to be based on the clustering algorithm. This study analyzes the social network information dissemination mechanism in the field of college students’ sports, obtains the real-time social behavior data in the network environment combined with the analysis results, and processes the obtained social network behavior data from two aspects of data cleaning and de-duplication. Using clustering algorithm to determine the (...) type of social network user behavior, setting the characteristics of social network behavior attributes, and finally through quantitative and standardized processing, get the results of college students’ sports field social network behavior characteristics extraction. The experimental results showed that the completeness of the method feature extraction results improved to 9.93%, and the average extraction time cost was 0.344 s, with high result integrity and obvious advantages in the extraction speed. (shrink)

Internet addiction is a growing social problem with negative mental and social outcomes; the present study examined whether rejection sensitivity mediates the relationship between interparental conflict and adolescent IA and the moderating role of school connectedness. One thousand and seven adolescents anonymously completed questionnaires to assess interparental conflict, school connectedness, rejection sensitivity, IA, and demographic information. The model results showed that: the positive association between interparental conflict and adolescent IA was partially mediated by rejection sensitivity; this indirect link was moderated (...) by the school connectedness and was stronger for adolescents with high school connectedness. The results provide support for the attachment theory that high interparental conflict could increase adolescents’ rejection sensitivity, and high school connectedness plays a double-edged role that adolescents show more rejection sensitivity while reporting high interparental conflict and high school connectedness. (shrink)

As the autonomous vehicles technology gradually enters the public eye, understanding consumers' psychological motivations for accepting autonomous vehicles is critical for the development of autonomous vehicles and society. Previously, researchers have explored the determinants of fully autonomous vehicles but the relevant research is far from enough. Moreover, the relationship between anthropomorphism and users' behavior has been ignored to a large extent. Therefore, this study aim to fill the gap by using anthropomorphism and the unified theory of acceptance and use of (...) technology to explore how system attributes and UTAUT attributes influence consumers' acceptance behavior. The data were collected via questionnaire survey conducted in Beijing, China, which can be a promising early adopter of AVs. Structural equation modeling was used to analyze the data. The results reveal that perceived anthropomorphism and perceived intelligence have a direct positive influence on the adoption of AVs; performance expectancy, effort expectancy, and facilitating conditions have an indirect positive influence on intention to adopt AVs. Also, this research contributes to the literature by enriching studies on psychological determinants of autonomous vehicles' adoption by taking an initial step to highlight anthropomorphism perceptions. This can provide managerial implications for policy-makers and businesses on how to effectively allocate resources to enhance autonomous vehicle adoption. (shrink)

Patients requiring deep brain stimulation due to intracerebral metallic foreign substances have not been reported elsewhere in the world. Additionally, the long-term effects of metallic foreign bodies on deep brain stimulation are unknown. A 79-year-old man with a 5-year history of Parkinson's disease reported that, 40 years ago, while playing with a pistol, a metallic bullet was accidentally discharged into the left brain through the edge of the left eye, causing no discomfort other than blurry vision in the left eye. (...) DBS was performed due to the short duration of efficacy for oral medication. Because the bullet was on the left subthalamic nucleus electrode trajectory and the patient's right limb was primarily stiff, the patient received globus pallidus interna -DBS implantation in the left hemisphere and STN-DBS implantation in the right hemisphere. During a 6-month postoperative follow-up, the patient's PD symptoms were effectively managed with no noticeable discomfort. (shrink)

In the complex environment, the suddenly changing structural parameters and abrupt actuator failures are often encountered, and the negligence or unproper handling method may induce undesired or unacceptable results. In this paper, taking the suddenly changing structural parameters and abrupt actuator failures into consideration, we focus on the robust adaptive control design for a class of heterogeneous Takagi–Sugeno fuzzy nonlinear systems subjected to discontinuous multiple uncertainties. The key point is that the switch modes not only vary with the system time (...) but also vary with the system states, and the intrinsic heterogeneous characteristics make it difficult to design stable controllers. Firstly, the concepts of differential inclusion are introduced to describe the heterogeneous fuzzy systems. Meanwhile, a fundamental lemma is provided to demonstrate the criteria of the boundness for a Filippov solution. Then, by using the set-valued Lie derivative of the Lyapunov function and introducing a vector of specific continuous functions, the closed-loop T-S fuzzy differential inclusion systems are proved to be ultimately bounded. The sufficient conditions for system stability are derived in term of linear matrix inequalities, which can be solved directly. Finally, a numerical example is provided to illustrate the effectiveness of the proposed control algorithm. (shrink)

A sequent calculus S for the variety tqBa of all topological quasi-Boolean algebras is established. Using a construction of syntactic finite algebraic model, the finite model property of S is shown, and thus the decidability of S is obtained. We also introduce two non-distributive variants of topological quasi-Boolean algebras. For the variety TDM5 of all topological De Morgan lattices with the axiom 5, we establish a sequent calculus S5 and prove that the cut elimination holds for it. Consequently the decidability (...) of S5 is established. Furthermore, this proof-theoretic method is applied to some subvarieties of TDM5. (shrink)

We explored whether children could apply linguistic strategies for lying, i.e., manipulating linguistic content of speech to mislead others. We announced a knowledge-test entailing prizes in the classrooms of a primary school and a middle school. Altogether 79 Chinese children (6-18 years) voluntarily participated in the test: listening to a series of animal sounds before guessing the names of the animals. Meanwhile, behind the participants, a video was playing images that ostensibly corresponded to the sounds being played. In fact, this (...) was not necessarily the case, i.e., some items cannot be solved because the sounds played are not from any animal but machine-synthesized. Participants were instructed not to look back at the video. However, 51 children peeked at the video for the unsolvable items, although the peeking behavior decreased with age. Moreover, when explaining how they correctly guessed the unsolvable items, children as young as six years old were able to apply a linguistic strategy (i.e., "capability attribution") for lying. Besides "capability attribution", Children also applied "fortune attribution" and "topic shift" for lying. Finally, "fortune attribution" and "topic shift" increased with age. Therefore, educators need to be aware that children are able to apply verbal strategies for lying that could involve truthful statements (i.e., "topic shift") or statements that are difficult to be proved as untruthful (i.e., "fortune attribution"). (shrink)

Objective: To investigate the correlation between preoperative response to the L-dopa challenge test and efficacy of deep brain stimulation (DBS) on motor function in Parkinson’s disease (PD).Methods: We retrospectively reviewed the data of 38 patients with idiopathic PD who underwent DBS surgery with a median follow-up duration of 7 months. Twenty underwent bilateral globus pallidus interna (GPi) DBS, and 18 underwent bilateral subthalamic nucleus (STN) DBS. The Movement Disorder Society Unified Parkinson Disease Rating Scale-Motor Part (MDS UPDRS-III) was assessed before (...) surgery and at the last follow-up in different medication and stimulation conditions, respectively.Results: Pearson’s correlation analysis revealed a positive correlation between preoperative L-dopa challenge responsiveness and GPi-DBS responsiveness on the total score (R2 = 0.283, p = 0.016) but not on the non-tremor total score (R2 = 0.158, p = 0.083) of MDS UPDRS-III. Such correlation remained significant (R2′ = 0.332, p = 0.010) after controlling for age at the time of surgery as confounding factor by partial correlation analysis. The preoperative L-dopa challenge responsiveness was significantly correlated with the tremor-controlling outcome of GPi-DBS (R2 = 0.390, p = 0.003). In contrast, we found a positive correlation between preoperative L-dopa challenge responsiveness and STN-DBS responsiveness on the non-tremor total score (R2 = 0.290, p = 0.021), but not on the total score (R2 = 0.130, p = 0.141) of MDS UPDRS-III. The partial correlation analysis further demonstrated that the predictive value of preoperative L-dopa challenge responsiveness on the non-tremor motor outcome of STN-DBS was eliminated (R2′ = 0.120, p = 0.174) after controlling for age at the time of surgery as confounding factor.Interpretation: The short-term predictive value of preoperative response to the L-dopa challenge test for the motor outcome of GPi-DBS in PD was systematically described. Our findings suggest: (1) a solid therapeutic effect of GPi-DBS in treating L-dopa-responsive tremors; (2) a negative effect of age at the time of surgery on motor outcomes of STN-DBS, (3) a possible preference of STN- to GPi-DBS in L-dopa-resistant tremor control, and (4) a possible preference of GPi- to STN-DBS in elderly PD patients who have a satisfactory dopamine response. (shrink)

As was previously known, pediatric medical staff in China faced several hurdles including high occupational risk, multiple contradictions, heavy workload, and long working hours. After the outbreak of 2019 novel coronavirus, facing the overload of work and the potential risk of infection, pediatric medical workers may be under great psychological pressure. The purpose of this article was to call attention to the impact of the epidemic on the mental health of Chinese pediatric workers, and developing psychological intervention program that are (...) tailored to them. The experiences from this public health emergency should inform the efficiency and quality of future crisis intervention of the Chinese government and authorities around the world. (shrink)

ObjectivesSocial function is an important indicator for physical and psychological health of older adults. However, there is a lack of a standardized questionnaire for measuring social function of older adults. This study developed a questionnaire to assess Chinese older adults’ social function.MethodsWe used three samples to test the reliability and validity of the questionnaire.ResultsBased on exploratory and confirmatory factor analyses with two samples, the final version of Social Function Questionnaire for Chinese Older Adults contained three dimensions with 12 items: social (...) support, social adaptation, and social engagement. Criterion validity test with the third sample showed that SFQCOA was positively related to the healthy indices and negatively related to the unhealthy indices.ConclusionThe validity and reliability of the questionnaire reach the requirements of psychometric standards, suggesting it is an effective tool for measuring social function of older adults. (shrink)