Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...) show that the dsRBD-NLS can mediate nuclear import of a reporter protein via interaction with importins β, 7, and 8. In the context of full-length Dicer, the dsRBD-NLS is masked. However, duplication of the dsRBD localizes the full-length protein to the nucleus. Furthermore, deletion of the N-terminal helicase domain results in partial accumulation of Dicer in the nucleus upon leptomycin B treatment, indicating that CRM1 contributes to nuclear export of Dicer. Finally, we demonstrate that human Dicer has the ability to shuttle between the nucleus and the cytoplasm. We conclude that Dicer is a shuttling protein whose steady-state localization is cytoplasmic. (shrink)

In a small literary gem full of sardonic wit, brilliant insights, and provocative criticism Witold Gombrowicz discusses Kant, Hegel, Schopenhauer, Kierkegaard, Sartre, and Heidegger in six "one-hour" essays—and addresses Marxism in a "fifteen-minute" piece. "Who hasn't wished for a painless way to find out what the big shots of philosophy—Hegel and Kant, Nietzsche and Sartre—thought of the human condition? It has never been easy reading such formidable thinkers, and most explainers and textbooks either get it wrong or massacre the (...) language. So imagine my pleasure in opening Witold Gombrowicz's _Guide to Philosophy in Six Hours and Fifteen Minutes_, an exceptional effort at summarizing concepts in bold, declarative sentences.... [This book] is like the course in philosophy you wish you had taken."—David Lehman, _Bloomberg News_ "A must for every reader of Gombrowicz."—Denis Hollier, New York University. (shrink)

During the 1944 Warsaw Uprising Witold Kieżun served in the Home Army’s “Harnaś” [Highlander] Special Unit. During an assault on the Polish Post he personally took 14 Germans prisoner, seizing large quantities of arms. He also singlehandedly damaged a German tank in the district Wola. A unit under his command captured the parish office of the Holy Cross Church and a heavy machinegun, and was the first to enter the city’s police headquarters, where it seized another heavy gun.During the (...) Uprising Witold Kieżun was decorated with the Cross of Valor, he also received the Virtuti Militari from the hands of the Home Army Supreme Commander. (shrink)

Most discussions of the reproducibility crisis focus on its epistemic aspect: the fact that the scientific community fails to follow some norms of scientific investigation, which leads to high rates of irreproducibility via a high rate of false positive findings. The purpose of this paper is to argue that there is a heretofore underappreciated and understudied dimension to the reproducibility crisis in experimental psychology and neuroscience that may prove to be at least as important as the epistemic dimension. This is (...) the communication dimension. The link between communication and reproducibility is immediate: independent investigators would not be able to recreate an experiment whose design or implementation were inadequately described. I exploit evidence of a replicability and reproducibility crisis in computational science, as well as research into quality of reporting to support the claim that a widespread failure to adhere to reporting standards, especially the norm of descriptive completeness, is an important contributing factor in the current reproducibility crisis in experimental psychology and neuroscience. (shrink)

Studies on music in the area of cognitive sciences – quite varied despite their short history – meet with scepticism. The author of this introduction, presenting some spectacular examples of research on musical improvisation, tries to demonstrate that they enrich rather than reduce our understanding of this phenomenon.

The considerations presented in the paper are an attempt to prove that free access to all scientific publications is evaluated on some world scientific forum. Scientists have to make selections among scientific publications again and again. In order to economise the scientist' time it is proposed to execute selections in three phases: the first phase - preliminary - even without seeing the relevant publications, and only on the basis of the title, author's name, names of publishers and journals, list of (...) references, blurbs etc.; the second phase (with the relevant publications at hand) - the verification of results of the first preliminary phase on the basis of rough reviewes of the publications; the third phase - selective - the verification of results of the second phase by attentive studies of selected publications. (shrink)

There seems to be something mysterious about applications of for- mal systems, including those of logic, to empirical reality 1 . If logic is to be applied to empirical situations, like those described in an ordinary lan- guage, then { it seems to some people { its statements cannot be necessary, or analytic, propositions. However, they are both applicable and necessary. This supposed puzzle constitutes a signicant part of the problem of philo- sophical foundations of logic 2 . To this (...) mind of the present writer, there is no mystery of applications, since any empirical, or even ostensive, predicate can be involved in cer- tain meaning postulates, e.g. \No red is green", which are both empirical and necessary propositions; empirical as they involve ostensibly dened predicated; necessary, as it is enough to know their meaning to state, their validity. The case of logical theorems can be considered at the same footing, logical constants being treated as dened ostensively. Nevertheless, not an individual state of mind but the actual state of scholarly discussions makes something a problem; in the present state of foundational discussions on logic, the \mystery of applications" preserves its vitality, hence any new way of dealing with it proves welcome. (shrink)

According to the Catholic Social Teaching, tax evasion is ethically reprehensible and people who do it commit sin. The Catholic Church based its opinion first of all on the Holy Scripture (the teaching of Jesus, St. Peter’s and St. Paul’s). Also pope John Paul II, primate of Poland Stefan cardinal Wyszyński and Joseph cardinal Höffner objected to tax frauds. The survey was conducted among the students of the University of Lodz and of the Medical University of Lodz. Its aim was (...) to examine the students’ opinion about tax evasion. The students’ answers were grouped with regard to church attendance in order to trace if there exists a correlation between church attendance and tax morality. Statistical analysis indicated a connection between church attendance and tax morality. The highest tax morality was noticed in the group of regularly practising Catholics, a bit smaller in the non-practising or unbelieving group of people and the least tax morality was noticed among the irregularly practising group of Catholics. According to the students’ opinion, the main reason to pay taxes is for fear of financial sanction. Among other reasons the respondents listed that it is a national duty or that it is necessary to cover national expenditures. It is optimistic, however, that most of the students declared to pay the taxes fairly, if they run their own corporations in the future. (shrink)

The affirmative answer to the title question is justified in two ways: logical and empirical. The logical justification is due to Gödel’s discovery that in any axiomatic formalized theory, having at least the expressive power of PA, at any stage of development there must appear unsolvable problems. However, some of them become solvable in a further development of the theory in question, owing to subsequent investigations. These lead to new concepts, expressed with additional axioms or rules. Owing to the so-amplified (...) axiomatic basis, new routine procedures like algorithms, can be reached. Those, in turn, help to gain new insights which lead to still more powerful axioms, and consequently again to ampler algorithmic resources. Thus scientific progress proceeds to an ever higher scope of solvability. The existence of such feedback cycles –in a formal way rendered with Turing’s systems of logic based on ordinal – gets empirically supported by the history of mathematics and other exact sciences. An instructive instance of such a process is found in the history of the number zero. Without that insight due to some ancient Hindu mathematicians there could not arise such an axiomatic theory as PA. It defines the algorithms of arithmetical operations, which in turn help intuitions; those, inturn, give rise to algorithmic routines, not available in any of the previous phases of the process in question. While the logical substantiation of the point of this essay is a well-established result of logico-semantic inquiries, its empiricalclaim, based on historical evidences, remains open for discussion. Hence the author’s intention to address philosophers and historians of science, and to encourage their critical responses. (shrink)

World War II broke out as the result of an alliance between Germany and Soviet Union with the aim to conquer and partition Poland. Having broken off the treaty of friendship and co-operation, Germany attacked the USSR in 1941, forcing the Soviet Union to change sides from that of a German ally to the ally of the anti-German coalition. In 1943, following the German discovery of the graves of Polish officers murdered by Soviet forces in Katyń, Stalin declared that the (...) crime had been committed by the German army and broke off diplomatic relations with the Polish Government-in-Exile in London which had requested that an official investigation be launched by the Red Cross committee in Geneva. Some one hundred German officers were sentenced to death for the Katyń massacre as the result of Stalin’s prosecution trials. 50 years later, the world was rocked by the discovery of a document signed by Stalin ordering the execution of Polish officers in Katyń.In a secret meeting in 1943 in Teheran, President Roosevelt and Stalin agreed on the plan to annex Poland’s eastern territories.The decision to stage an independent fight for independence during the Warsaw Uprising was justified by the inevitable approach of the Red Army, the fear of German reprisal actions for disobeying the order to participate in fortification works, the fear of a spontaneous uprising fuelled by a Soviet radio broadcast in Polish which appealed to the people of Warsaw to put up a fight against the oppressor.Stalin’s decision to withhold the Soviet offensive and ban American and British planes carrying humanitarian aid for Warsaw from landing in Soviet airports contributed to the downfall of the Uprising. The Warsaw Uprising was a cue for the civil outbreaks that followed in Slovakia, Romania, Bulgaria, Paris and Prague. The halt on the Soviet Army’s offensive, which enabled the German forces to eliminate the Polish centre of political command subordinate to the Government-in-Exile in London, limited the European territory that fell subject to Soviet supremacy. The memory of the heroic fight put up by the entire population of Warsaw deterred the Soviet Union’s ambitions to curtail Poland’s sovereignty. (shrink)