Two medical essays in the hand of John Locke survive amongst the Shaftesbury Papers in the National Archives (National Archives PRO 30/24/47/2, ff. 31r–38v and ff. 49r–56r). Since the 1960s their authorship has been disputed. Some scholars have attributed them to the London physician Thomas Sydenham, others have attributed them to Locke. Detailed analyses of their contents and the context of their composition provide very strong evidence for Lockean authorship. This is reinforced by the application of the most recent (...) techniques of computational stylistics. (shrink)

The clinical empiricism of Thomas Sydenham (1624–1689) and his definition of especie morbosae represented a substantial turn in the medicine of his time. This turn supposed the shift towards an ontological conception of diseases, from a qualitative to quantitative interpretation. Sydenham’s clinical proposal had a great influence on empiricism philosophical thinking, particularly in John Locke and his delimitation of knowledge. The dialogue between medicine and philosophy, set out by Sydenham-Locke, reactivates the problem of the clinical and theoretical foundations of (...) medical thought, as well as the limits of scientific knowledge. Similar to problem exposed in the Hippocratic treatise On ancient medicine, seventeenth-century medicine seeks its epistemological foundations and the solution to its difficulties in clinical experience, probability and analogy. The aim of this work is to show the Sydenham’s contribution to one of the great controversies between medicine and philosophy. (shrink)

This paper examines the contents of the sixth paragraph of the “Tyrrell Memoir”. This paragraph makes some strong, critical claims about both Locke’s “obsession” with the London physician Thomas Sydenham, and his purported dismissive attitude towards another physician, Richard Lower. In the paragraph, Tyrrell sides with the First Earl of Shaftesbury’s mocking attitude towards the triumvirate Locke, his close friend David Thomas, and Sydenham, and relates some extraordinary and hitherto unknown anecdotes. Tyrrell’s claims are assessed in relation to (...) what we know about the relations between these four men and in relation to the current state of Sydenham historiography. (shrink)

In this article I contrast 17th and 18th explanations of hysteria including those of Sydenham and Willis with those given by Plato and pre-modern medicine. I show that beginning in the second decade of the 17th century the locus of the disorder was transferred to the nervous system and it was no longer connected with the womb as in Hippocrates and Galen; hysteria became identified with hypochondria, and was a disease contracted by men as well as women. I discuss the (...) purely mechanical explanation of hysteria given by Robert Boyle who attributed its cause to corporeal ideas as well as overly sensitive disposition of the nervous system. I relate this the mechanical theory of the nervous system prominent in Descartes' writings on physiology. The paper closes with a discussion of the contrast between early modern explanations of hysteria and the nature of man with those of Freud in the early 20th century. (shrink)

John Locke’s medical interests resulted in several short texts in which he criticizes two theoretical conceptions of his days, paracelsianism and galenism. Two of the texts – ‘ Morbus’ and ‘ Anatomia’ – show the influence of Thomas Sydenham on Locke’s understanding of medicine which can be summarized as a turn towards clinical medicine and empirical investigations. The article reconstructs this early stage of the development of Locke’s standpoint leading to ‘ An Essay Concerning Human Understanding’.

Following a recent trend in the field of the history of philosophy and medicine, this paper stresses the necessity of recognizing empiricism’s patent indebtedness to the sciences of the body. While the tribute paid to the Hippocratic method of observation in the work of Thomas Sydenham is well known, it seems necessary to take into account a trend more critical of ancient medicine developed by followers of chemical medicine who considered the doctrine of elements and humours to be a (...) typical example of the idols that hinder the improvement of medical knowledge and defend the necessity of experimentation. In light of the fact that modern discoveries resulted in a “new frame of human nature,” they developed a critical reading of ancient empiricism. As a consequence, we can distinguish between two distinct anti-speculative traditions in the genesis of philosophical empiricism. The first recommends an active investigation into nature and refers to the figure of Democritus, the ancient philosopher who devoted himself to the dissection of beasts. Defenders of this first tradition refuse point-blank to be called ‘empiricists’, a label which had a very negative meaning during the seventeenth century, when it was used to dismiss charlatans and quacks. The other tradition, stressing as it does the role of description and observation, is more sceptical of the ability of dissection or anatomy to give us access to causes of diseases. This later tradition comes closer to the definition of ancient empiricism and to the figure of Hippocrates. (shrink)

Locke wrote Draft A of the Essay while collaborating with physician Thomas Sydenham. Sydenham held that we are ignorant of nature's internal workings, cannot decide which natural philosophical theories are true and should therefore rely only upon experience. Draft A repeated Sydenham's views — we cannot understand nature's modus operandi and must rely on experience for our knowledge of the world. Equally, we must be agnostic about natural philosophical theories, mechanism included. Locke was not a mechanist in Draft A. (...) Consequently, Locke's account of substance, first articulated in this Draft and repeated in the Essay, was completely independent of the mechanical philosophy. (shrink)

This work reflects on hypochondria as well as on the global functioning of the human mind and on the place of the patient/physician relationship in the wider organisation of society. First published in 1711, revised and enlarged in 1730, and now edited and published with a critical apparatus for the first time, this is a major work in the history of medical literature as well as a complex literary creation. Composed of three dialogues between a physician and two of his (...) patients, Mandeville’s Treatise mirrors the digressive structure of a talking cure. Thanks to the soothing and enlightening effects of this casual conversation, the physician Mandeville demonstrates the healing power of words for a class of patients that he presents as men of learning who need above all to be addressed in their own language. Mandeville’s aim was to delineate his own cure for hypochondria and hysteria, which consisted of a talking cure followed by diet and exercise, but also to discuss the practice of medicine in England and continental Europe at a time when physicians were beginning to lose ground to apothecaries. Opposing a purely theoretical approach to medicine, Mandeville takes up the principles presented by Francis Bacon, Thomas Sydenham, and Giorgio Baglivi, and advocates a medical practice based on experience and backed up by time-tested theories. (shrink)

Tekst został napisany najprawdopodobniej w roku 1668. Podstawą przekładu są jego dwie edycje: Kennetha Dewhursta, zamieszczona przezeń w monografii Thomas Sydenham. His Life and Original Writings, University and California Press, Berkeley–Los Angeles 1966, s. 85–93 oraz bardziej szczegółowa transkrypcja dokonana przez Jonathana Craiga Walmsleya i zamieszczona w rozprawie doktorskiej John Locke’s Natural Philosophy, opublikowanej elektronicznie: https://core.ac.uk/download/files/99/74250.pdf. Powodem umieszczenia przez Dewhursta tekstu Anatomii w książce poświęconej Sydenhamowi był brak pewności co do jej autorstwa; choć pierwotnie badacz ten przypisał go Locke’owi, (...) po pewnym czasie zmienił zdanie, uznając, że autorem był jednak Sydenham. Powodem był m.in. fakt, że pierwszy akapit napisany został ręką Sydenhama, co skłoniło Dewhursta do przypuszczenia, że rola Locke’a sprowadzała się jedynie do pełnienia obowiązków sekretarza znanego angielskiego lekarza. O autorstwie Sydenhama miała świadczyć także zbieżność poglądów zawartych w tekście z treścią jego Observationes Medicae. Ustalenia te podważyli ostatnio Peter Anstey i John Burrows, którzy analizując źródła i wykorzystując narzędzia statystyczne, rozstrzygnęli – należy sądzić, że ostatecznie – sprawę autorstwa Anatomii na korzyść Locke’a ). (shrink)

This paper argues that the construction of natural histories, as advocated by Francis Bacon, played a central role in John Locke's conception of method in natural philosophy. It presents new evidence in support of John Yolton's claim that "the emphasis upon compiling natural histories of bodies ... was the chief aspect of the Royal Society's programme that attracted Locke, and from which we need to understand his science of nature". Locke's exposure to the natural philosophy of Robert Boyle, the medical (...) philosophy of Thomas Sydenham, his interest in travel literature and his conception of the division of the sciences are examined. From this survey, a cumulative case is presented which establishes, independently of an in-depth exegesis of his Essay Concerning Human Understanding, the central role for Locke of the construction of natural histories in natural philosophy. (shrink)

John Locke's philosophy was deeply affected by medicine of his times. It was specially influenced by the medical thought and practice of Thomas Sydenham. Locke was a personal friend of Sydenham, expressed an avid interest in his work and shared his views and methods. The influence of Sydenham's medicine can be seen in the following areas of Locke's philosophy: his “plain historical method”; the emphasis on observation and sensory experience instead of seeking the essence of things; the rejection of (...) hypotheses and principles; the refusal of research into final causes and inner mechanisms; the ideal of irrefutable evidence and skepticism on the possibilities of certainty in science. The science which for Locke held the highest paradigmatic value in his theory of knowledge was precisely medicine. To a great extent, Locke's Essay on Human Understanding can be understood as an attempt to justify, substantiate, and promote Sydenham's medical method. This method, generalized, was then proposed as an instrument for the elaboration of all natural sciences. (shrink)

La vieillesse constitue une pierre de touche pour toute théorie médicale : elle oblige à rendre raison de la temporalité à l’œuvre dans la vie. Aux yeux de Stahl, les iatromécaniciens méconnaissent la dimension temporelle de l’organisme ; en particulier, ils en ignorent la périodicité. Comprendre la vieillesse suppose donc la critique de la représentation linéaire du temps organique, que développe la mécanique et qui réduit le vivant au seul composé physique et chimique. Il reste alors à trouver la cause (...) de la périodicité organique : sur ce point, Georg Ernst Stahl critique Thomas Sydenham, qui reconnaît certes la périodicité du vivant mais nie la possibilité d’une médecine étiologique. Pour sa part, le médecin de Halle cherche à rendre compte du vieillissement en lien avec les actions organiques fondamentales : le tonus, la circulation, l’excrétion, la sécrétion. (shrink)

Locke was born in Wrington, Somerset, on 29 August 1632. After the Civil War he was sent to Westminster School, and in 1652 to Christ Church, Oxford. A feature of the university in Locke's early years was growing interest in the natural sciences, fostered by, amongst others, Robert Boyle, John Wilkins, and Robert Hooke. After graduating, Locke was much attracted to the work of these men, and soon he was engaged in medical research with Robert Boyle. He remained in Oxford (...) until 1667, when a chance meeting with Anthony Ashley Cooper, later Lord Shaftesbury, led to his joining Shaftesbury's London household, which from then on became Locke's usual residence, and where he acted as Shaftesbury's personal physician, conducted research with Thomas Sydenham. and became a Fellow of the Royal Society. (shrink)

Archaeology can provide two bodies of information relevant to the understanding of the evolution of human cognition – the timing of developments, and the evolutionary context of these developments. The challenge is methodological. Archaeology must document attributes that have direct implications for underlying cognitive mechanisms. One example of such a cognitive archaeology is found in spatial cognition. The archaeological record documents an evolutionary sequence that begins with ape-equivalent spatial abilities 2.5 million years ago and ends with the appearance of modern (...) abilities in the still remote past of 400,000 years ago. The timing of these developments reveals two major episodes in the evolution in spatial ability, one, 1.5 million years ago and the other, one million years later. The two episodes of development in spatial cognition had very different evolutionary contexts. The first was associated with the shift to an open country adaptive niche that occurred early in the time range of Homo erectus. The second was associated with no clear adaptive shift, though it does appear to have coincided with the invasion of more hostile environments and the appearance of systematic hunting of large mammals. Neither, however, occurred in a context of modern hunting and gathering. Key Words: Archaeology; evolution; Homo erectus; spatial cognition; symmetry. (shrink)

Inequality is widely regarded as morally objectionable: T. M. Scanlon investigates why it matters to us. He considers the nature and importance of equality of opportunity, whether the pursuit of greater equality involves objectionable interference with individual liberty, and whether the rich can be said to deserve their greater rewards.

[ROYAL INSTITUTE OF PHILOSOPHY 2023 ESSAY PRIZE WINNER] I argue that the term ‘naturalism’ is so empty of meaning that it is not suitable for serious theorizing in philosophy. In particular, I argue that the question of whether or not some theory or thesis should count as naturalistic is an empty verbal dispute with no further theoretical significance. I also discuss naturalism construed as a methodological thesis and argue that any plausible version will collapse into triviality. Lastly, I briefly discuss (...) the idea that naturalism is not a thesis at all but rather a ‘stance’ and suggest that this too succumbs to the charge of emptiness. I conclude that we should stop talking about naturalism altogether. (shrink)

Thomas Wylton's Quaestio de anima intellectiva presents a controversial defence of Averroes' interpretation of Aristotelian psychology. The detailed introduction guides the reader through the transmission of the text, as well as the philosophical contents of one of the most significant medieval treatments of the nature of the soul.

This book is a fiftieth anniversary republication of Thomas Nagel's "What Is It Like to Be a Bat?", a classic in the philosophy of mind. Through its argument for the irreducible subjectivity of consciousness, it played an essential role in making the study of consciousness a central part of philosophy, psychology, and neuroscience. It also spurred the now flourishing scientific attention to the consciousness of non-human creatures: mammals, birds, fish, mollusks, and insects. The book also includes a second essay (...) offering Nagel's more recent thoughts on the most promising positive response to the mind-body problem, as posed in the original essay. (shrink)

Many traditional theists maintain that God is the ultimate explanation of the universe, for why anything exists at all. For the traditional theist, only a being who is fundamental and transcendent can provide an ultimate ground and explanation of the universe. This requirement that God transcend the universe in order to ultimately explain it poses a challenge for pantheism, the view that God is numerically identical with the universe. If God is identical with the universe, and God is supposed to (...) be the ultimate explanation of the universe, the result is an instance of circular explanation. And circular explanations are allegedly illegitimate. In this article, I develop two explanatory models in an attempt to show that pantheism is consistent with non-circular explanations of the universe. All else being equal, I argue that pantheism is not explanatorily deficient in comparison to traditional theism. (shrink)

Sartre's moral thinking progressed from an abstract, idealistic ethics of authenticity to a more concrete, realistic, and materialistic morality. Much of Sartre's important unpublished work on ethics - relevant to both his 'first' and his 'second' ethics - has become available to scholars only in the years since his death. Only now has it become possible to give a complete presentation of both the first and the second ethics and to accurately identify their relationship. Sartre's Two Ethics also presents Professor (...) Anderson's original criticisms of Sartre's two ethics, and concludes that the second is a significant advance over the first. (shrink)

This open access book is a superb collection of some fifteen chapters inspired by Schroeder-Heister's groundbreaking work, written by leading experts in the field, plus an extensive autobiography and comments on the various contributions by Schroeder-Heister himself. For several decades, Peter Schroeder-Heister has been a central figure in proof-theoretic semantics, a field of study situated at the interface of logic, theoretical computer science, natural-language semantics, and the philosophy of language. -/- The chapters of which this book is composed discuss the (...) subject from a rich variety of angles, including the history of logic, the proper interpretation of logical validity, natural deduction rules, the notions of harmony and of synonymy, the structure of proofs, the logical status of equality, intentional phenomena, and the proof theory of second-order arithmetic. All chapters relate directly to questions that have driven Schroeder-Heister's own research agenda and to which he has made seminal contributions. The extensive autobiographical chapter not only provides a fascinating overview of Schroeder-Heister's career and the evolution of his academic interests but also constitutes a contribution to the recent history of logic in its own right, painting an intriguing picture of the philosophical, logical, and mathematical institutional landscape in Germany and elsewhere since the early 1970s. The papers collected in this book are illuminatingly put into a unified perspective by Schroeder-Heister's comments at the end of the book. Both graduate students and established researchers in the field will find this book an excellent resource for future work in proof-theoretic semantics and related areas. (shrink)

Capacitarianism says that an agent can be non-derivatively blameworthy for wrongdoing if at the time of their conduct the agent lacked awareness of the wrong-making features of their conduct but had the capacity to be aware of those features. In this paper, I raise three objections to capacitarianism in relation to its verdict of the culpability of so-called “slips” and use these objections to support a rival (“accessibility internalist”) view which requires awareness of wrong-making features for non-derivative blameworthiness. The objections (...) are that (1) the rival internalist view is just as capable of explaining the culpability of paradigm cases of slips; (2) there are some cases of slips without dispositional awareness of wrong-making features that capacitarians wrongly deem culpable; and (3) capacitarianism cannot adequately ground the reasonable expectation to avoid slips (as Fernando Rudy-Hiller has argued). I then argue that an internalist can simultaneously ground a reasonable expectation to avoid slips and account for slips’ culpability by pointing to the satisfaction of a novel epistemic condition: it is (dispositionally) obvious to the slipping agent that they need to pay enough attention to what they are doing, and how to pay enough attention, to reliably achieve the goal that they have set out to achieve. (shrink)

Cognitivism about trust says that it requires belief that the trusted is trustworthy; non-cognitivism denies this. At stake is how to make sense of the strong but competing intuitions that trust is an attitude that is evaluable both morally and rationally. In proposing that one's respect for another's agency may ground one's trusting beliefs, second-personal accounts provide a way to endorse both intuitions. They focus attention on the way that, in normal situations, it is the person whom I trust. My (...) task is to develop an account of the latter insight without the controversial theoretical commitments of the former. I propose a functional account for why the second and third-personal ‘systems’ operate not just in parallel, but in tandem, in support of a cognitivist account of trust. (shrink)

In this important book, Thomas R. Flynn reinterprets and evaluates Sartre's social and political philosophy, arguing that the existential ethics of Sartre's ...

A new public philosophy began to emerge in the United States during the Progressive Era. Promoted by such intellectuals as John Dewey, William James, and the coUectivists of the New Republic magazine, it called for a citizenry trained in an experimental milieu, free of dogma and emancipated from sources of allegiance other than the new centralized democratic state then being forged. Catholics, however, neither capitulated to the new creed nor retreated into a self-righteous isolation. In a culture whose chief value (...) was pluralism they insisted on the uniqueness of the Church and the need for making value judgments based on a sound philosophy of man. (shrink)

An essential element of human resource management (HRM) is employee growth and development. Two aspects of this development involve growth in job related behaviours and the less tangible but vital aspect of personal growth. The paper focuses on the latter topic. The aim is an exploration of the relationship between experience and education as they relate to personal growth. Since many schools of management and in-house HRM programmes involve the use of experiential approaches to learning, it seems a relevant issue (...) for discussion. In fact, a strong case is made for the use of experience as a critical part of the personal education and growth process. Logical, rational analysis, poetic device, and teaching stories are used to highlight the role of experience. Extensive use is made of developmental notions from Buddhism, Confucianism, Sufism and Taoism. Reference is made to the Kolb et al. learning cycle model to help examine the personal growth experience. The paper discusses both the role of the educator and the role of the employee or seeker of personal growth. The educational process is discussed in terms of negating as well as affirming, abandoning old ideas as well as gaining new ones. Proposed educational aims for the learner are identified. (shrink)

In this article, we argue that rational persuasion can be a _pro tanto_ wrong and that online platforms possess features that are especially conducive to this wrong. We begin by setting out an account of rational persuasion. This consists of four jointly sufficient conditions for rational persuasion and is intended to capture the core, uncontroversial cases of such persuasion. We then discuss a series of wrong-making features which are present in methods of influence commonly thought of as _pro tanto_ wrong, (...) such as manipulation and paternalism. It is next shown that these wrong-making features are also present in a range of cases that are, by the jointly sufficient conditions already established, rational persuasion, and so some forms of rational persuasion are _pro tanto_ wrong, including in some ways that have not previously been remarked upon. Finally, we demonstrate that online settings possess a number of features that are especially conducive to wrongful rational persuasion. (shrink)

by Victor Farías, translated from Spanish and German into French by Myriam Benarroch and Jean-Baptiste Grasset, preface by Christian Jambet. Editions Verdier, 332 pp., Fr125 (paper).

Journal of Business Ethicsrecently published a critique of ethical practices in quantitative research by Zyphur and Pierides (J Bus Ethics 143:1–16, 2017). The authors argued that quantitative research prevents researchers from addressing urgent problems facing humanity today, such as poverty, racial inequality, and climate change. I offer comments and observations on the authors’ critique. I agree with the authors in many areas of philosophy, ethics, and social research, while making suggestions for clarification and development. Interpreting the paper through the pragmatism (...) of William James, I suggest that the authors’ arguments are unlikely to change attitudes in traditional quantitative research, though they may point the way to a new worldview, or Jamesian “sub-world,” in social research. (shrink)

Codes of ethics are directly aimed at behavioral control, but they also affect a company’s ethical culture, which in turn concerns compliance and ethical behavior. To positively influence a company’s ethical culture, employees must be familiar with its code of ethics, perceive that top management is committed to the code, and believe that their peers also comply with the code. The evidence on whether a code’s design affects a company’s ethical culture is limited. This study’s factorial survey experiment contributes to (...) this gap in two ways: first, it investigates whether a code’s design affects how easily the code can be learned and, therefore, contributes to code familiarity. Second, it examines how a code can convey expectations regarding top management’s commitment and peers’ behavior, both of which are part of ethical culture. The results indicate that a positive tone increases code familiarity, and a code signed by top managers sends a strong signal of their commitment to the code. Finally, various implications of the results for research and practice are discussed. (shrink)

Beginning with the well-knowncyber-rape in LambdaMOO, I argue that it ispossible to have real moral wrongs in virtualcommunities. I then generalize the account toshow how it applies to interactions in gamingand discussion communities. My account issupported by a view of moral realism thatacknowledges entities like intentions andcausal properties of actions. Austin's speechact theory is used to show that real people canact in virtual communities in ways that bothestablish practices and moral expectations, andwarrant strong identifications betweenthemselves and their online identities. Rawls'conception (...) of a social practice is used toanalyze the nature of the wrong and thestage-setting aspect of engaging in a practice. (shrink)

The most contentious tenet of Husserl's phenomenology of feelings is his conclusion that there is an analogy between axiological reason and theoretical reason. Simply, Husserl asserts that the axiological validation of feelings is analogical to the theoretical validation of judgments. While the scholarship has debated the merits of Husserl's analogy over the last 120 years, this paper presents a new accurate interpretation, because it is the first to highlight how Husserl develops this analogy by most often comparing the fulfillment of (...) judgments to the fulfillment of wish feeling intentions. Specifically, I examine how Husserl analogizes wish fulfillment to theoretical fulfillment at different times; in the 1901 Logical Investigations, in his 1908 Lectures on Ethics, and in 1910 manuscripts from Studien zur Struktur des Bewusstseins. In light of this original interpretation, I conclude by arguing – contra popular readings – that Husserl does not over‐intellectualize feelings and their validation. (shrink)

Some theories of goodness are descriptively rich: they have much to say about what makes things good. Neo-Aristotelian accounts, for instance, detail the various features that make a human being, a dog, a bee good relative to facts about those forms of life. Famously, such theories of relative goodness tend to be comparatively poor: they have little or nothing to say about what makes one kind of being better than another kind. Other theories of goodness—those that take there to be (...) absolute goodness—are comparatively rich: they offer grounds for judging some types of things better than others because they have more absolute goodness. Moorean accounts, for example, can tell us that humans and human experiences are superior to bees and blades of grass. But such theories tend to be descriptively poor: they struggle to tell us in virtue of what this is so. In this essay we motivate and flesh out a view that splits the difference between accounts of goodness as relative and accounts of goodness as absolute. Such a view holds promise only if the mechanics of this kind of metaphysics of goodness can be worked out. Here we present a view on which the paradigm for absolute goodness is God and the paradigm for each kind of relative goodness is a divine idea. (shrink)

Horwich proposes a solution to the liar paradox that relies on a particular notion of grounding—one that, unlike Kripke’s notion of grounding, does not invoke any “Tarski-style compositional principles”. In this short note, we will formalize Horwich’s construction and argue that his solution to the liar paradox does not justify certain generalizations about truth that he endorses. We argue that this situation is not resolved even if one appeals to the \-rule. In the final section, we briefly discuss how Horwich (...) might respond to the situation. (shrink)

The problem of the many poses the task of explaining mereological indeterminacy of ordinary objects in a way that sustains our familiar practice of counting these objects. The aim of this essay is to develop a solution to the problem of the many that is based on an account of mereological indeterminacy as having its source in how ordinary objects are, independently of how we represent them. At the center of the account stands a quasi-hylomorphic ontology of ordinary objects as (...) material objects with multiple individual forms. (shrink)

Immunology — though deeply experimental in everyday practice — is also a theoretical discipline. Recent advances in the understanding of innate immunity, how it is triggered and how it shares features that have previously been uniquely ascribed to the adaptive immune system, can contribute to the refinement of the theoretical framework of immunology. In particular, natural killer cells and macrophages are activated by transient modifications, but adapt to long-lasting modifications that occur in the surrounding tissue environment. This process facilitates the (...) maintenance of self-tolerance while permitting efficient immune responses. In this Essay we extend this idea to other components of the immune system and we propose some general principles that lay the foundations for a unifying theory of immunity — the discontinuity theory. According to this theoretical framework, effector immune responses (namely, activated responses that lead to the potential elimination of the target antigen) are induced by an antigenic discontinuity; that is, by the sudden modification of molecular motifs with which immune cells interact. (shrink)