The issue of representing access control requirements continues to demand significant attention. The focus of researchers has traditionally been on developing particular access control models and policy specification languages for particular applications. However, this approach has resulted in an unnecessary surfeit of models and languages. In contrast, we describe a general access control model and a logic-based specification language from which both existing and novel access control models may be derived as particular cases and from which several approaches can be (...) developed for domain-specific applications. We will argue that our general framework has a number of specific attractions and an implication of our work is to encourage a methodological shift from a study of the particulars of access control to its generalities. (shrink)

Digital media seem to be marked by process. The digital image itself is produced by software processes and the constant flux of code. Further this, interaction with digital systems involves a constant process by which a so-called 'user' comes into contact with various machinic occasions. It seems that in light of these processes it is impossible to maintain an aesthetic or media theory that pictures a self-contained and psychologised subject interacting with a static and inert object. How then can we (...) begin to think about digital aesthetics through a process philosophy rather than the traditional and reductive subject/object distinction found in so much aesthetic theory? This paper seeks to address this problem by enacting Alfred Whitehead's process philosophy, informed by Gilles Deleuze, Isabelle Stengers and Steve Shaviro and work it through several examples of recent manifestations of interactive media art, including work by Martin Wattenberg, Dennis Del Favero, Jeffrey Shaw and Peter Weibel. I work Whitehead's process philosophy through these artworks to illustrate the performative nature of software processes and the manner in which these processes affect the aesthetics of interaction. I also use these works to illustrate a concept of interaction that privileges process and events rather than a concept that focuses upon an individual human user. In this paper I propose to view the 'user' as a set of occasions – as a particular condition that is produced by various user-initiated actions – rather than an enduring subject that is able to distance herself from the object of aesthetic contemplation. By doing this I move toward a theory in which user-occasions, machine-occasions and their interpenetration actualise the aesthetics of media art. Whitehead allows me to think outside of the binary oppositions that divide the world into knower/known or subject/object relationships. Throughout the argument I unpack Whiteheadian concepts such as actual entities, the unison of immediate becoming and, in general, the primacy of the event, bringing these concepts to bear on individual case studies of interactive media art. Whitehead's general thesis is that materiality and permanence are created by a continual process. Viewing the digital encounter through this theoretical framework I position the aesthetic experience of interaction as that which emerges from the fluctuations of process. The event of interaction is a necessarily hybrid process in which human occasions become supplemented by technology and the aesthetic event becomes innately coupled to the processes of the machine. In this paper I am not interested in any notion of consciousness or a psychologised human 'user', rather I am interested in a particular condition that takes place as user-initiated processes work with machine-initiated processes. This is because, for Whitehead, process comes before consciousness; it is the process of actual entities that prompt the consciousness into being. In this paper I thus propose interaction with digital systems as the commingling of contemporary actual occasions, shifting emphasis from a conscious human user and instead focusing on the process of the encounter that precedes this conscious experience. (shrink)

This volume presents new work in history and historiography to the increasingly broad audience for studies of the history and philosophy of science. These essays are linked by a concern to understand the context of early modern science in its own context.

In what ways should we include future humanoid robots, and other kinds of artificial agents, in our moral universe? We consider the Organic view, which maintains that artificial humanoid agents, based on current computational technologies, could not count as full-blooded moral agents, nor as appropriate targets of intrinsic moral concern. On this view, artificial humanoids lack certain key properties of biological organisms, which preclude them from having full moral status. Computationally controlled systems, however advanced in their cognitive or informational capacities, (...) are, it is proposed, unlikely to possess sentience and hence will fail to be able to exercise the kind of empathic rationality that is a prerequisite for being a moral agent. The organic view also argues that sentience and teleology require biologically based forms of self-organization and autonomous self-maintenance. The organic view may not be correct, but at least it needs to be taken seriously in the future development of the field of Machine Ethics. (shrink)

In this article, we posit that a cross-scale perspective is valuable for studies of organizational resilience. Existing research in our field primarily focuses on the resilience of organizations, that is, the factors that enhance or detract from an organization’s viability in the face of threat. While this organization level focus makes important contributions to theory, organizational resilience is also intrinsically dependent upon the resilience of broader social-ecological systems in which the firm is embedded. Moreover, long-term organizational resilience cannot be well (...) managed without an understanding of the feedback effects across nested systems. For instance, a narrow focus on optimizing organizational resilience from one firm’s perspective may come at the expense of social-ecological functioning and ultimately undermine managers’ efforts at long-term organizational survival. We suggest that insights from natural science may help organizational scholars to examine cross-scale resilience and conceptualize organizational actions within and across temporal and spatial dynamics. We develop propositions taking a complex adaptive systems perspective to identify issues related to focal scale, slow variables and feedback, and diversity and redundancy. We illustrate our theoretical argument using an example of Unilever and palm oil production in Borneo. (shrink)

Examining the origin and development of my views of social epistemology, I contrast my position with the position held by analytic social epistemologists. Analytic social epistemology (ASE) has failed to make significant progress owing, in part, to a minimal understanding of actual knowledge practices, a minimised role for philosophers in ongoing inquiry, and a focus on maintaining the status quo of epistemology as a field. As a way forward, I propose questions and future areas of inquiry for a post-ASE to (...) address. (shrink)

Despite Kant's belief in a universal causal determinism among phenomena and his rejection of any noumenal agency in brutes, he nevertheless rejected Descartes's hypothesis that brutes are machines. Explaining Kant's response to Descartes forms the basis for this discussion of the nature of consciousness and matter in Kant's system. Kant's numerous remarks on animal psychology-as found in his lecture notes and reflections on metaphysics and anthropology-suggest a theory of consciousness and self-consciousness at odds with that traditionally ascribed to him.

I compare a ‘realist’ with a ‘social–relational’ perspective on our judgments of the moral status of artificial agents (AAs). I develop a realist position according to which the moral status of a being—particularly in relation to moral patiency attribution—is closely bound up with that being’s ability to experience states of conscious satisfaction or suffering (CSS). For a realist, both moral status and experiential capacity are objective properties of agents. A social relationist denies the existence of any such objective properties in (...) the case of either moral status or consciousness, suggesting that the determination of such properties rests solely upon social attribution or consensus. A wide variety of social interactions between us and various kinds of artificial agent will no doubt proliferate in future generations, and the social–relational view may well be right that the appearance of CSS features in such artificial beings will make moral role attribution socially prevalent in human–AA relations. But there is still the question of what actual CSS states a given AA is capable of undergoing, independently of the appearances. This is not just a matter of changes in the structure of social existence that seem inevitable as human–AA interaction becomes more prevalent. The social world is itself enabled and constrained by the physical world, and by the biological features of living social participants. Properties analogous to certain key features in biological CSS are what need to be present for nonbiological CSS. Working out the details of such features will be an objective scientific inquiry. (shrink)

: We question the claim, common since Duhem, that sixteenth century astronomy, and especially the Wittenberg interpretation of Copernicus, was instrumentalistic rather than realistic. We identify a previously unrecognized Wittenberg astronomer, Edo Hildericus (Hilderich von Varel), who presents a detailed exposition of Copernicus's cosmology that is incompatible with instrumentalism. Quotations from other sixteenth century astronomers show that knowledge of the real configuration of the heavens was unattainable practically, rather than in principle. Astronomy was limited to quia demonstrations, although demonstration propter (...) quid remained the ideal. We suggest that Osiander's notorious preface to Copernicus expresses these sixteenth century commonplaces rather than twentieth century instrumentalism, and that neither `realism', nor `instrumentalism', in their modern meanings, apply to sixteenth century astronomy. (shrink)

Are all instances of the T-schema assertable? I argue that they are not. The reason is the presence of conventional implicature in a language. Conventional implicature is meant to be a component of the rule-based content that a sentence can have, but it makes no contribution to the sentence's truth-conditions. One might think that a conventional implicature is like a force operator. But it is not, since it can enter into the scope of logical operators. It follows that the semantic (...) content of a sentence is not given simply by its truth-conditional content. So not all instances of the T-schema are assertable in the relevant sense. Consequently, there is a strong case to be made against truth-conditional semantics of the disquotational variety and deflationism about truth. (shrink)

Appeals to intuitions as evidence in philosophy are challenged by experimental philosophers and other critics. A common response to experimental philosophical criticisms is to hold that only professional philosophers? intuitions count as evidence in philosophy. This ?expert intuitions defence? is inadequate for two reasons. First, recent studies indicate significant variability in professional philosophers? intuitions. Second, the academic literature on professional intuitions gives us reasons to doubt that professional philosophers develop truth-apt intuitions. The onus falls on those who mount the expert (...) intuitions defence to meet these objections because it is implicitly being claimed that training and practice caused professional philosophers to acquire reliably accurate intuitions and we are owed an account of how this transformation takes place. A possible response to this situation is to attempt to reform philosophical practice to improve the quality of intuitions. Another possible response, advocated here, is to avoid appeals to intuitions as evidence. (shrink)

It seems to be generally accepted that (a) counterfactual conditionals are to be analysed in terms of possible worlds and inter-world relations of similarity and (b) causation is conceptually prior to counterfactuals. I argue here that both (a) and (b) are false. The argument against (a) is not a general metaphysical or epistemological one but simply that, structurally speaking, possible worlds theories are wrong: this is revealed when we try to extend them to cover the case of probabilistic counterfactuals. Indeed (...) a type of counterfactual probability exists which cannot be expressed in possible worlds terms at all. The argument against (b) emerges when we look at the form of an adequate account of both probabilistic and non-probabilistic counterfactuals. I do this by sketching and defending an approach to counterfactuals that, first, invoke a generalized notion of cause as primitive and, secondly, is algorithmic in form: counterfactuals are evaluated algorithmically in terms of other counterfactuals, without vicious circularity. Structures like possible worlds do not play a role either in general truth-conditions or in evaluation. They are simply the wrong sorts of structures. (shrink)

The primary goal of this paper is not to argue for the “influence” of Cassirer, but rather to make known the reception of Cassirer in Japanese philosophy, illustrate the interconnection between Cassirer’s critique of culture and that of Japanese philosophy, and hopefully spark interest in what might be a fruitful dialog between Cassirer scholars and those working in Japanese philosophy. Historically, the paper defines Japanese philosophy and makes known its engagement with Western philosophy and the Marburg school of neo-Kantianism and (...) its project of a critique of culture during its own self-development. Systematically, the paper points to the possible interconnection between Cassirer’s critique of culture and that of Japanese philosophy and makes the case for a mutually productive dialog between Cassirer scholars and those working in Japanese philosophy. Implicitly, the paper attempted to show that an engagement with Japanese philosophy from the perspective of a critique of culture forces us to question the Western dichotomy between philosophy and religion and the importance of this for the further development of a non-Eurocentric critique of culture. And by extension, that a critique of culture must be cognitive of the historicity of the culture from which it speaks. (shrink)

I discuss the realizability and the ethical ramifications of Machine Ethics, from a number of different perspectives: I label these the anthropocentric, infocentric, biocentric and ecocentric perspectives. Each of these approaches takes a characteristic view of the position of humanity relative to other aspects of the designed and the natural worlds—or relative to the possibilities of ‘extra-human’ extensions to the ethical community. In the course of the discussion, a number of key issues emerge concerning the relation between technology and ethics, (...) and the nature of what it is to have moral status. Some radical challenges to certain technological presuppositions and ramifications of the infocentric approach will be discussed. Notwithstanding the obvious tensions between the infocentric perspective on one side and the biocentric and ecocentric perspectives on the other, we will see that there are also striking parallels in the way that each of these three approaches generates challenges to an anthropocentric ethical hegemony, and possible scope for some degree of convergence. (shrink)

Social persons routinely tell themselves and others richly elaborated autobiographical stories filled with details about deeds, plans, roles, motivations, values, and character. Saul, let us imagine, is someone who once sailed the world as a young adventurer, going from port to port and living a gypsy existence. In telling his new acquaintance, Jess, of his former exotic life, he shines a light on his present character and this may guide to some extent their interaction here and now. Perhaps Jess also (...) spent time at one of these port locations; perhaps their paths might even have crossed. They might be drawn into recounting some common events that indeed do establish a common link. Did they visit a certain famous landmark? Did they meet up at the same bars? And so on. When we open up to friends, acquaintances, colleagues, and close others through the stories we tell them, we do so by revealing bits of ourselves. (shrink)

The present paper shows that the clearest formulation of J. M. E. McTaggart's antipassage argument, that of D. H. Mellor in _Real Time II, is unsound when its premises are interpreted so that it is valid. This argument need mislead us no longer. The crucial item in the interpretation of the premises is the copula 'is', as in 'E is past'. The copula may be either tensed or tenseless. While this ambiguity of the copula has been noted before, its implications (...) for McTaggart's argument had not been adequately exploited. This paper does that job. (shrink)

Two critiques of simple adaptationism are distinguished: anti-adaptationism and extended adaptationism. Adaptationists and anti-adaptationists share the presumption that an evolutionary explanation should identify the dominant simple cause of the evolutionary outcome to be explained. A consideration of extended-adaptationist models such as coevolution, niche construction and extended phenotypes reveals the inappropriateness of this presumption in explaining the evolution of certain important kinds of features—those that play particular roles in the regulation of organic processes, especially behavior. These biological or behavioral ‘levers’ are (...) distinctively available for adaptation and exaptation by their possessors and for co-optation by other organisms. As a result they are likely to result from a distinctive and complex type of evolutionary process that conforms neither to simple adaptationist nor to anti-adaptationist styles of explanation. Many of the human features whose evolutionary explanation is most controversial belong to this category, including the female orgasm. (shrink)

ABSTRACT The influence of Cassirer's work on Bakhtin's writings from the 1930s has been studied in some detail but scholars have not examined Bakhtin's early work, Toward a Philosophy of the Act (K filosofii postupka), in connection with Cassirer's philosophy. The article first reveals how attuned Bakhtin was with the intellectual Zeitgeist not only of his own times, but also that of the 20th century. The uncanny intellectual harmony between the ideas of Bakhtin and Cassirer can be seen at the (...) very beginning of Bakhtin's career. The two thinkers are united in their reception, transformation, and attempt to reconcile two antithetical philosophical positions dominant at the beginning of the 20th century: the transcendental philosophy of Kant, Neo-Kantianism, and the Lebensphilosophie of Simmel, Bergson, and Heidegger. Bakhtin and Cassirer were alarmed by the cultural pessimism and potential nihilism inherent in the position of Lebensphilosophie. Next, the author shows ways in which Bakhtin's and Cassirer's ideas resonate with those of the later 20th century Jacques Derrida. (shrink)

I argue that Lewis's counterfactual theory of causation, given his treatment of counterfactuals in terms of world-comparative similarity faces insuperable problems in the form of the problem of effects and the problem of epiphenomena.

I argue that Copernicus accepted the reality of celestial spheres on the grounds that the equant problem is unintelligible except as a problem about real spheres. The same considerations point to a number of generally unnoticed liabilities of Copernican astronomy, especially gaps between the spheres, and the failure of some spheres to obey the principle that their natural motion is to rotate. These difficulties may be additional reasons for Copernicus's reluctance to publish, and also stand in the way of strict (...) realism as applied to De Revolutionibus, although a realistic astronomy may be envisioned as a goal for Copernicus's research program. (shrink)

: This paper continues my application of theories of concepts developed in cognitive psychology to clarify issues in Kuhn's mature account of scientific change. I argue that incommensurability is typically neither global nor total, and that the corresponding form of scientific change occurs incrementally. Incommensurability can now be seen as a local phenomenon restricted to particular points in a conceptual framework represented by a set of nodes. The unaffected parts in the framework constitute the basis for continued communication between the (...) communities supporting alternative structures. The importance of a node is a measure of the severity of incommensurability introduced by replacing it. Such replacements occur incrementally so that changes like that from the conceptual structure of Aristotelian celestial physics to the conceptual structure of Newtonian celestial physics occur in small stages over time, and for each change it is in principle possible to identify the arguments and evidence that led historical actors to make the revisions. Thus the process of scientific change is a rational one, even when its beginning and end points are incommensurable conceptual structures. It is also apparent, from a detailed examination of the conceptual structure of astronomy at the time of Copernicus, thatthe kind of conceptual difficulty identified as incommensurability may occur within a single scientific tradition as well as between two rival traditions. (shrink)

A comprehensive theory ofeven if needs to account for consequent ‘entailing’even ifs and in particular those of theif-focused variety. This is where the theory ofeven if ceases to be neutral between conditional theories. I have argued thatif-focusedeven ifs,especially if andonly if can only be accounted for through the suppositional theory ofif. Furthermore, a particular interpretation of this theory — the conditional assertion theory — is needed to account foronly if and a type of metalinguistic negation ofQ if P. We therefore (...) have evidence that the currently accepted approaches to conditionals are basically wrong about the semantic forms they attribute toif P, Q.11. (shrink)

This paper provides a reading of Nishitani’s philosophy of culture. It argues that the advent of nihilism is the logical conclusion of what will be called the “fracturing of culture” in which philosophy and religion lose their creative force to revitalize a cultural tradition as the sense of being-in-time that forms the historical life of a historical world. Section two sets out the paradoxical nature of Nishitani’s philosophy of culture as both a transcendental and existential project. Section three draws attention (...) to the fact that a concept of culture always belongs to a concrete culture as part of its own understanding of itself. Section four interprets the advent of nihilism in terms of a crisis of culture that ensues from the loss of the existential understanding of history that grounds a cultural world, that forms the standpoint of a historical event of worlding, the historical life that we are. Section five examines Nishitani’s project in terms of the reappropriation of a lost tradition through an existential receptive reinterpretation of Buddhism. Section six argues that for Nishitani the advent of nihilism comes about as a result of the negation of myth by science and thus the overcoming of nihilism comes about through the recollection of myth. Section seven determines the nature of myth for Nishitani through a comparison with Cassirer’s and Heidegger’s understanding of myth. Three elements of myth are focused on: 1) myth as an existential confrontation with being-in-the-world; 2) this existential being-in-the-world forms an existential being-in-time; and 3) myth is the position of the imagination, a thinking by means of form-images [keizō 形像] (Bild, image). Section seven considers the difference between Cassirer’s and Nishitani’s respective accounts of myth. Section nine examines the nature and function of philosophy, science, and religion in terms of their relation to myth and in terms of how they understand interdependent origination. Section, ten ends the paper by considering what is called the “fracturing” of culture and the advent of nihilism. (shrink)

In the last decade, many arguments have emerged for encouraging public participation in environmental policy making and management While some have argued that, in democratic societies, people simply have a right to a participatory role, others base arguments for public participation on the idea that lay people may have access to knowledge which is unknown to officially sanctioned experts. Local people may count as experts about aspects of their neighbourhood or they may have insights into the behaviour of plant operators (...) that is thought to give rise to pollution. This paper reports on a novel empirical approach to analysing and capturing such 'lay' understandings. This technique, developed in ESRC-funded work in the UK, uses community mapping exercises in urban centres to produce spatial representations of local knowledges about air pollution and related problems of noise and odour. In the paper the technique is outlined, presenting data from the three-city case study. The paper concludes by assessing the ways in which participatory modelling can contribute to the local governance of air quality. (shrink)

The American Journal of Bioethics, Volume 12, Issue 10, Page 39-41, October 2012.

Kant’s body offered a constant target for his own remarks, both in correspondence and during his lunchtime conversations. Several good descriptions of Kant’s body have come down to us over the centuries, as well as a number of visual representations, but these are remarkably limited, given his stature in the world of ideas. A new description of Kant, written by a novelist who visited Kant while passing through Königsberg, has recently come to light. It is reproduced here — in English (...) translation as well as the original German — and earlier descriptions of Kant are briefly recounted. (shrink)

In this investigation of the Japanese film Kairo, I contemplate how the horrors present in the film relate to the issue of self, by examining a number of interlocking motifs. These include thematic foci on disease and technology which are more intimately and inwardly focused that the film's conclusion first appears to suggest. The true horror here, I argue, is ontological: centred on the self and its divorcing from the exterior world, especially founded in an increased use of and reliance (...) on communicative technologies. I contend that these concerns are manifested in Kairo by presenting the spread of technology as disease-like, infecting the city and the individuals who are isolated and imprisoned by their urban environment. Finally, I investigate the meanings of the apocalypse, expounding how it may be read as hopeful for the future rather than indicative of failure or doom. (shrink)

Sunohara Yuuri and Akita Masami’s series of six seppuku films (1990) are solely constituted by images of fictionalized death, revolving around the prolonged self-torture of a lone figure committing harakiri. I contend that the protagonist’s auto-immolation mirrors a formal death, each frame ‘killing’ the moment it represents. My analysis aims to explore how the solipsistic nature of selfhood is appositely symbolized by the isolation of the on-screen figures and the insistence with which the six films repeat the same scenario of (...) protracted agony across the cycle. The centralization of suffering, I argue, parallels the distance between viewer and image with the isolating nature of embodied existence. Thus, this article seeks to probe the relationship between form and content, asking what the image of death reveals about the death of the image. -/- . (shrink)

Although overshadowed by its filmic adaptations (Hideo Nakata, 1998 and Gore Verbinski, 2002), Koji Suzuki’s novel Ring (1991) is at the heart of the international explosion of interest in Japanese horror. This article seeks to explore Suzuki’s overlooked text. Unlike the film versions, the novel is more explicitly focused on the line between self-preservation and self-sacrifice, critiquing the ease with which the former is privileged over the latter. In the novel then, the horror of Sadako’s curse raises questions about the (...) terrors of moral obligation: the lead protagonist (Asakawa) projects the guilt he feels over his self-interested actions, envisaging them as an all-consuming apocalypse. (shrink)

Both the slasher movie and its more recent counterpart the "torture porn" film centralize graphic depictions of violence. This article inspects the nature of these portrayals by examining a motif commonly found in the cinema of homicide, dubbed here the "pure moment of murder": that is, the moment in which two characters’ bodies adjoin onscreen in an instance of graphic violence. By exploring a number of these incidents (and their various modes of representation) in American horror films ranging from Psycho (...) (1960) to Saw VI (2009), the article aims to expound how these images of slaughter demonstrate (albeit in an augmented, hyperbolic manner) a number of long-standing problems surrounding selfhood that continue to fuel philosophical discussion. The article argues that the visual adjoining of victim and killer onscreen echoes the conundrum that in order to attain identity, the individual requires and yet simultaneously repudiates the Other that constitutes unique subjectivity. (shrink)

The Oxford Handbook of Japanese Philosophy is by all counts an ambitious work. Its primary goal is to provide the reader with a foundational framework in which to engage interpretively the tradition of Japanese philosophy. It would be impossible to summarize, let alone do justice to, the thirty-six rich and illuminating chapters written by many of the most prominent scholars in the field from Japan, Europe, Australia, and North America.Navigating between the "violence of inclusion" that would reduce the philosophically other (...) to our own conception of philosophy and the "violence of exclusion" that would fail to recognize what we share with this other, Bret Davis... (shrink)

Horror film sequels have not received as much serious critical attention as they deserve – this is especially true of the Saw franchise, which has suffered a general dismissal under the derogatory banner ‘Torture Porn’. In this article I use detailed textual analysis of the Saw series to expound how film sequels employ and complicate expected temporal and spatial relations – in particular, I investigate how the Saw sequels tie space and time into their narrative, methodological and moral sensibilities. Far (...) from being a gimmick or a means of ensuring loyalty to the franchise (one has to be familiar with the events of previous episodes to ascertain what is happening), it is my contention that the Saw cycle directly requests that we examine the nature of space and time, in terms of both cinematic technique and our lived, off-screen temporal/spatial orientations. -/- . (shrink)

Oliver Cromwells historical reputation underwent significant change during the nineteenth century. Writers such as Thomas Carlyle were prominent in this reassessment, creating a Cromwell that found particular support among Nonconformists in the north of England. Projects to memorialize Cromwell included the raising of public statues. This article traces the history of the Manchester statue, the first major outdoor statue of Cromwell to be unveiled in the country. The project originated among Manchester radical Liberal Nonconformists in the early 1860s but was (...) not realized until 1875. It was the gift of Elizabeth Heywood; the sculptor was Matthew Noble. The project, including its intended site in Manchesters new Town Hall, was contentious, exposing political and religious divisions within the community, reinforcing the view that the reassessment of Cromwells place in the making of modern Britain was far from settled. (shrink)

Recent studies indicate that plakoglobin may have a similar function to that of β-catenin within the Wnt signaling pathway. β-catenin is known to be an oncogene in many forms of human cancer, following acquisition of stabilizing mutations in amino terminal sequences. Kolligs1 and coworkers show, however, that unlike β-catenin, plakoglobin induces neoplastic transformation of rat epithelial cells in the absence of such stabilizing mutations. Cellular transformation by plakoglobin also appears to be distinct from that of β-catenin in that it requires (...) activation of the proto-oncogene c-myc. Surprisingly, c-myc is activated more efficiently by plakoglobin than β-catenin, despite its previous identification as a target of Tcf/β-catenin.2 In contrast, a synthetic Tcf reporter gene is activated to a much greater extent by β-catenin than plakoglobin. Plakoglobin and β-catenin may therefore have different roles in Wnt signaling and cancer, which reflect their differential effects on target gene activity. BioEssays 22:961–965, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Charles Dickens’s work has been taken and adapted for many different ends. Quite a lot of attention has been given to film and television versions of the novels, many of which are very distinguished. The stage and screen musical based on his work, essentially a product of the last fifty years, has been neither as studied nor as respected. This paper looks at the connection between Dickens’s novels, the celebration of “London-ness” and its articulation in popular forms of working-class music (...) and song. It will argue that potentially unpromising texts were taken and used to articulate pride and a sense of community for groups representing the disadvantaged of the East End and, more specifically, for first-generation Jewish settlers in London. This is all the more surprising as it was in the first instance through depictions of Oliver Twist and the problematic figure of Fagin that an Anglo-Jewish sensibility was able to express itself. Other texts by Dickens, notably Pickwick Papers, A Christmas Carol and The Old Curiosity Shop, were also adapted to musical forms with varying results, but the period of their heyday was relatively short, as their use of traditional and communitarian forms gave place in the people’s affection to manufactured pop/rock and operetta forms. I will argue that this decline was partly the product of changing London demographics and shifts in theatre economics and partly of the appropriation of Dickens by the academy. (shrink)

David Fairweather Foxon, a Fellow of the British Academy, published English Verse 1701–1750: a Catalogue, a book that not only took a long leap forward into a new century; it also provided a cross-section through the record of all British books and books printed abroad in English in a period in which the total number of books, periodicals, and ephemera began to increase exponentially. The period was also one in which the whole concept of authorship and the relationship between author (...) and the book trade changed substantially, as a result of the Copyright Act. Foxon was born in Paignton, the son of a Methodist minister. Bletchley Park was a crucial experience for him, socially and intellectually. He met a variety of gifted academics, some eccentric, mostly from Oxford or Cambridge, at an early age; it gave him training in codebreaking; and it introduced him to his future wife. Foxon was involved in the recataloguing of the British Museum Library, a gigantic undertaking that had begun in 1929. (shrink)

This is a discussion and transcription of a “lose Blatt” of Immanuel Kant’s that was recently located in the Dibner Library of the Smithsonian Institute in Washington D.C. It briefly comments on (1) religious delusion [Andachtswahn], (2) Kant’s pedagogical aims, (3) virtue and the general will, and (4) perceptual relativism of magnitude. The sheet may have belonged to a group stemming from Kant’s copy of his Observations on the Beautiful and Sublime (1764), and its provenance can be traced to Rudolf (...) Reicke, the Königsberg librarian and Kant scholar of the late 19th century. (shrink)