Almost all messenger RNAs carry a polyadenylate tail that is added in a post‐transcriptional reaction. In the nuclei of animal cells, the 3'‐end of the RNA is formed by endonucleolytic cleavage of the primary transcript at the site of poly (A) addition, followed by the polymerisation of the tail. The reaction depends on specific RNA sequences upstream as well as downstream of the polyadenylation site. Cleavage and polyadenylation can be uncoupled in vitro. Polyadenylation is carried out by poly(A) polymerase with (...) the aid of a specificity factor that binds the polyadenylation signal AAUAAA. Several aditional factors are required for the initial cleavage. A newly discovered poly(A)‐binding protein stimulates poly(A) tail synthesis and may be involved in the control of tail length. Polyadenylation reactions different from this scheme, either in other organisms or under special physiological circumstances, are discussed. (shrink)

This article discusses the metatheoretical foundations of a critical realist approach to critical discourse analysis and counterposes them to insufficiently realist tendencies in Norman Fairclough's critical discourse analysis, on the one hand, and anti-realist post-Marxist discourse theory on the other. The first section argues that Fairclough's approach is progressive in many ways, but lacks metatheoretical rigour with respect to important demarcation problems. These mainly concern CDA's understanding of discourse as mediating entity, its underlying dialectical-relational approach and overarching concept of social (...) practices. The discussion of Fairclough's approach necessitates a treatment of the relation of discourse and epistemology, in which the heritage of Foucault plays a crucial role and a brief engagement with ideology, in which Althusser is a major point of departure. The thesis is advanced that, among other things, Althusserian and Foucauldian residues in CDA's metatheory esta.. (shrink)

This paper discusses recent evidence that violations of core knowledge offer special learning opportunities for infants and young children. Children make predictions about the world from the youngest ages. When their fail to match observed data, they show an enhanced drive to seek and retain new information about entities that violated their expectations. Finally, the authors draw comparisons between children and adults, and with other species, to explore how surprise shapes thought more broadly.

NIHILISMUS ist seit Nietzsche das Schlüsselwort, das den Zugang zu unserer Epoche öffnen könnte. Doch wir haben ihn verschlossen, indem wir das Wort zum Unwort und Schmähwort erklären, obwohl der Nihilismus, dieser "unheimlichste Gast" schon längst in unserem Haus an unserem Tische sitzt. Wir selbst sind Nihilisten, obwohl wir den Nihilismus, kaum dass wir das Wort in den Mund genommen haben, schon überwinden möchten. Elmar Dod stellt sich in dieser philosophischen Studie dem Nihilismus, entwickelt ihn in seiner erregenden Bandbreite, (...) nimmt seine Herausforderung an, ohne nach bequemen Überwindungen zu schielen. Dabei zeigt er, wie wir als Nihilisten leben müssen, überleben können - sogar mit reicheren Möglichkeiten für eine ideologiefreie nihilistische Lebenspraxis. (shrink)

Medical research aims to achieve a better scientific understanding of health and disease. It is firstly undertaken for the improvement of medical care in general, not excluding a potential direct benefit for participants undergoing such research. There is a traditional conflict between the fundamental rights and the dignity of those participating individuals and the interests of science, researchers and even the society. The Convention of Human Rights and Biomedicine of the Council of Europe is a new legally binding instrument for (...) the solution of these conflicts. (shrink)

Distributive justice on the income and on the service aspects is the most vexing modern day problem for the creation and maintenance of an all inclusive health care system. A pervasive problem of all current schemes is the lack of effective cost control, which continues to result in increasing burdens for all public and private stakeholders. This proposal posits that the responsibility and financial obligation to achieve an ideal outcome of equal and affordable access and benefits for all citizens is (...) misplaced. The Good Samaritan demonstrated basic ethical principles, which are revisited, elaborated and integrated into a new approach to health care. The participants are limited to individual contributors and beneficiaries and organized as a citizen carried, closed, independent, and self-sufficient self-governing cooperative for their own and the benefit of a minority of disadvantaged health care consumers. The government assumes oversight, provides arbitration, enforces democratic decision making, a scheme of progressive taxation, a separate and transparent accounting system, and a balance between income and reinvestment in health care. The results are a fair distribution of cost, its effective control, and increased individual motivation to take on responsibility for personal health as a private good and a sharpened focus towards community health. At the sociopolitical level the government as well as employers are released from the inappropriate burden of catering to individual health. (shrink)

Das weltweit einzige und in seiner Konzeption einzigartige philosophische Fachwörterbuch - nun in 2., durchgesehener Auflage um ca. 20.000 Einträge erweitert - enthält rund 65.000 Stichwörter aus allen Sparten der Philosophie einschließlich aktueller und philosophisch relevanter Begriffe aus angrenzenden Wissenschaftsbereichen. Knappe, informative und übersichtliche Angaben zum Fachgebiet und Kontext ordnen alle Einträge ihrer Bedeutungsrichtung zu und verdeutlichen ihren Gebrauch. Ein differenziertes System von Querverweisen verbindet die Einträge miteinander und erleichtert dem Benutzer das Auffinden der korrekten Übersetzung.

I respond to comments from Mark Bowker, Jessica Keiser, and Eliot Michaelson on my book, Talking About. The response clarifies my stance on the nature of reference, conflicting intentions, and the sense in which language may have proper functions.

ABSTRACTMoran and Bar-Anan. The effect of object-valence relations on automatic evaluation. Cognition and Emotion, 27, 743–752) demonstrated that evaluations on...

The end of socialist utopias on the Fordian model, which today are in a state of general crisis and have become weakend in their foundations, calls for political forms capable of organizing new historical subjects appropriate to a new social structure.

Combining new insights from cognitive science and speech act theory, Unnsteinsson develops a compelling theory of singular reference which avoids well-known puzzles. The theory, Edenic intentionalism, is grounded in a mechanistic perspective on explanation in cognitive science and a new Gricean account of speaker meaning and speaker reference.

The article aims to contribute to the sociological theory of the welfare state by addressing a fundamental puzzle of social policy, namely, the weakness of its claim to be a rational effort of society dealing with problems of social integration. Drawing on the work of Franz-Xaver Kaufmann, I distinguish between the cultural or ideational side of the welfare state and the social engineering or outcome side, arguing to take the rhetoric and symbolism of social policy more seriously. The integration of (...) society is more due to the communicative action of social policy than to its organizational quality. As early as the axial age civilizations, symbolism and ideology emerged as an autonomous field of social conflict and societal union. Taking ancient Israel as an example, I argue that societal integration may take place even in the absence of strong institutional correlates of social politics. This can help to explain why the welfare state in modern society is compatible with ever-increasing economic and social inequality. (shrink)

Name der Zeitschrift: Frühmittelalterliche Studien Jahrgang: 47 Heft: 1 Seiten: 1-6.

Purpose: Explore public attitudes towards the trade-offs between justice and medical outcome inherent in organ allocation decisions.Background: The US Task Force on Organ Transplantation recommended that considerations of justice, autonomy and medical outcome be part of all organ allocation decisions. Justice in this context may be modeled as a function of three types of need, related to age, clinical urgency, and quality of life.Methods: A web-based survey was conducted in which respondents were asked to choose between two hypothetical patients who (...) differed in clinical urgency , age, pretransplant and post-transplant quality of life, and life expectancy.Results: A pool of 1600 people were notified via email about the survey; 623 responded. Respondents preferred giving organs to younger people up to an age difference of <15.4 years and more clinically urgent people up to a difference in urgency of <2.54 months . Priority varied with the quality of life of the worst-off patient and the relative status of the patients. If both had worse than average quality of life, respondents preferred the better-off patient. When both had better than average quality of life, they preferred the worse-off patient. In analysis according to age versus clinical urgency, the older the patient, the more urgency needed to receive priority. In quality of life versus clinical urgency, the better the control’s quality of life, the more urgency the competing patient required. The worse the patient’s post-transplant outcome, the more urgency needed to receive priority.Conclusions: It appears that clinical urgency is only one of many factors influencing attitudes about allocation decisions and that respondents may invoke different principles of fairness depending the relative clinical status of patients. (shrink)

Gricean intentionalists hold that what a speaker says and means by a linguistic utterance is determined by the speaker's communicative intention. On this view, one cannot really say anything without meaning it as well. Conventionalists argue, however, that malapropisms provide powerful counterexamples to this claim. I present two arguments against the conventionalist and sketch a new Gricean theory of speech errors, called the misarticulation theory. On this view, malapropisms are understood as a special case of mispronunciation. I argue that the (...) Gricean theory is supported by empirical work in phonetics and phonology and, also, that conventionalism inevitably fails to do this work justice. I conclude, from this, that the conventionalist fails to show that malapropisms constitute a counterexample to a Gricean theory. (shrink)

I argue that what speakers mean or express can be determined by their implicit or unconscious states, rather than explicit or conscious states. Further, on this basis, I show that the sincerity conditions for utterances can also be fixed by implicit states. This is a surprising result which goes against common assumptions about speech acts and sincerity. Roughly, I argue that the result is implied by two plausible and independent theories of the metaphysics of speaker meaning and, further, that this (...) is a robust basis on which to make an inference, with a fair degree of confidence, about the relationship between expression and implicit attitudes. (shrink)

Der Artikel verfolgt, in welcher Weise Johann Gottlieb Fichte mit seiner Wissenschaftslehre die Diskussion um das Wesen der Natur in ihrem Verhältnis zum Subjekt beeinflusst. Dabei wird besonders sein Ansatz zur Fassung der Subjektivität und der Dialektisierung der Erkenntnisbeziehung zwischen Subjekt und Objekt herausgearbeitet. Dabei wird Fichtes Beitrag zur Entwicklung einer modernen dialektischen Methode gewürdigt. -/- The article follows the way in which Johann Gottlieb Fichte influences the discussion about the essence of nature in its relationship to the subject with (...) his science theory. His approach to the definition of subjectivity and the dialectization of the cognitive relationship between subject and object will be worked out in particular. Fichte's contribution to the development of a modern dialectical method is acknowledged. -/- В статье показано, как Иоганн Готлиб Фихте влияет на дискуссию о сущности природы в ее отношении к предмету своей научной теорией. В частности, вырабатывается его подход к определению субъективности и диалектизации познавательных отношений между субъектом и объектом. Признан вклад Фихте в развитие современного диалектического метода. -/- El artículo sigue la forma en que Johann Gottlieb Fichte incide en la discusión sobre la esencia de la naturaleza en su relación con el sujeto con su teoría de la ciencia. En particular, se trabaja su aproximación a la definición de subjetividad y la dialéctica de la relación cognitiva entre sujeto y objeto. Se reconoce la contribución de Fichte al desarrollo de un método dialéctico moderno. (shrink)

This article seeks to establish a link between the field of business ethics and information ethics by exploring the connection between responsibility and the Internet from an economic perspective. This link finds its expression in the moral theory of Discourse Ethics as suggested by German philosophers such as Juergen Habermas and Karl‐Otto Apel. The term responsibility points in the direction of communication and therefore leads easily to discourse ethics. The economy in general and most economic practices also seem to be (...) intimately linked to questions of responsibility. The growing spread and importance of the Internet poses new challenges and problems but also creates new possibilities for ethics as well as for the economy. Here several of these new developments are analysed and their impact on ethics as well as economy assessed. Consequences for the use and development of information technology are considered. (shrink)

1. [without special title]--2. Alternation/Parallel montage.

The present review essay discusses Peter Bratsis’s work Everyday Life and the State. It is argued that Bratsis produces a sound contribution to the on-going debate on state theory, which has its particular strengths in the innovative treatment of the public-private divide and an elaborate critique of fetishistic and ideological relations in the field of the political. In this, Bratsis builds on a broad range of structuralist, poststructuralist and dialectical positions. Deficiencies of his work are likewise to be found in (...) this bricolage of theoretical approaches: it is argued that conflicting epistemological and ontological fundamentals are not sufficiently taken into account, which consequently leads to reductionist and errant conclusions. This is especially evident in the confusion of ‘structuralist’ and ‘dialectical’ heuristics, which leads to an insufficiently materialist picture of the state in relation to ‘everyday life’. (shrink)

Der Autor stellt die Geschichte des "Klassik-Seminars", einer philosophiehistorisch angelegten Veranstaltung der Philosophie-Sektion an der Universität Jena in den Jahren 1975-1990 zur Erforschung der Philosophie der deutschen Klassik vor. Er analysiert die Konzeption und präsentiert eine Bibliografie der veröffentlichten Beiträge. Die Präsentation auf der WEB-Seite des Autors geht dadurch über die gedruckte Fassung hinaus. -/- The author presents the history of the "Classic Seminar", a philosophical-historical event organized by the Philosophy Section at the University of Jena in the years 1975-1990 (...) to research the philosophy of German Classicism. He analyzes the conception and presents a bibliography of the published contributions. The presentation on the author's website goes beyond the printed version. (shrink)