We design an agent based Monte Carlo model of antibiotics research and development to explore the effects of the policy intervention known as Market Entry Reward on the likelihood that an antibiotic entering pre-clinical development reaches the market. By means of sensitivity analysis we explore the interaction between the MER and four key parameters: projected net revenues, R&D costs, venture capitalists discount rates, and large pharmaceutical organizations' financial thresholds. We show that improving revenues may be more efficient than reducing costs, (...) and thus confirm that this pull-based policy intervention effectively stimulates antibiotics R&D. (shrink)

Album photographique consacré au philosophe et écrivain français. Au total, 181 documents en noir et blanc assortis de commentaires assez brefs, répartis dans un ordre thématique (le professeur, l'écrivain, etc.) et en partie chronologique.

Currently held conceptions of autonomy that inform biomedicine are inadequate and oppressive. Liberal notions of individualism are anti-humanist and constitute pernicious socialization, which leads to internalized oppression and dehumanization, especially among already oppressed groups. Women in recovery from addiction and other mental illnesses are especially affected by anti-humanist conceptions of autonomy. I argue that these women need to receive treatment that supports autonomy through supplementing psychiatric and rehabilitative therapy with humanistic education and group therapy. Treatment must encourage the construction of (...) healthy social interaction that augments a sense of supported autonomy. (shrink)

1 – Introduction Le manuscrit De Torricelli à Pascal est un manuscrit que, pour des raisons que nous ignorons, Louis Rougier a renoncé ou a dû renoncer à publier, faute peut-être d’éditeur. Retrouvé par Denis Lelarge dans le fonds Rougier conservé à Lourmarin, la revue Philosophia Scientiæ a choisi d’en assurer la publication, trente ans ou presque après la mort de son auteur. Pourquoi ce choix? Quel intérêt présente ce manuscrit? Cet intérêt est triple. À commencer par le plus mani...

Emerging from thought-provoking discussions and correspondence Simone Weil had with the Reverend Father Perrin, this classic collection of essays contains her most profound meditations on the relationship of human life to the realm of the transcendant.An enlightening introduction by Leslie Fiedler examines Weil's extraordinary roles as a philosophy teacher turned mystic. "One of the most neglected resources of our century ", Waiting for God will continue to influence spiritual and political thought for centuries to come.

Gravity and Grace was the first ever publication by the remarkable thinker and activist, Simone Weil. In it Gustave Thibon, the priest to whom she had entrusted her notebooks before her untimely death, compiled in one remarkable volume a compendium of her writings that have become a source of spiritual guidance and wisdom for countless individuals.

ABSTRACTAs a postscript to this special issue, the author reflects on the difference between religion and ritual by drawing a comparison with culture and nature. In the same way that culture and nature are entangled yet distinct, so too religion and ritual are best understood as a paradoxical configuration of spiritual deliberation and unconscious desire. It is argued that religion and ritual exceed and depend on each other in equal measure as the organism explores new modes of living.

Die Forderungen nach naturgemäßem Leben, Einfachheit und Askese werden im antiken Denken oftmals in Verbindung gebracht. Vor dem Hintergrund der Frage, was naturgemäß leben im Rahmen verschiedener Ansätze bedeutet, wird untersucht, wie jeweils eine Verknüpfung mit Konzeptionen einfachen Lebens und damit verbundener Askese erfolgt. Ausgehend vom Naturbegriff der frühgriechischen Denker wird anhand von Textbeispielen dargestellt, wie die genannte Verbindung in der Ethik des 5./4. Jahrhunderts v. Chr. begründet und in den hellenistischen Schulen fortentwickelt wird. Gezeigt wird, dass Einfachheit und Askese (...) nach antiker Vorstellung die Verwirklichung der menschlichen Natur zum Ziel haben und, anders als im heutigen Denken, nicht etwa den Schutz natürlicher Ressourcen. (shrink)

On 24 January 41 the emperor Caligula was murdered. Modern scholarly interpretations mainly focus on the alleged attempt by the senate to restore the republic. Taking a different point of view, this paper focuses on the act of murder itself. Caligula’s assassination was, after all, an act of violence against an emperor - unprecedented in the principate so far. It is argued that, by portraying the killing as justified, the narratives of the conspiracy fulfilled two main functions. On the one (...) hand, they can be viewed as immediate responses to views which questioned the violence against Caligula. On the other hand, they develop mechanisms on how to deal with an emperor who was no longer deemed acceptable. (shrink)

The main goal of the paper is to investigate the relation between indicative conditionals and rationality. We wil l do this by consider- ing several interpretations of a very wel l-known example of reasoning involving conditionals, that is the Wason selection task, and showing how those interpretations have different bearings on the notion of ra- tionality. In particular, in the first part of the paper, after having briefly presented the selection task, we wil l take a look at two prag- (...) matic responses to the chal lenge posed by the task, through Wason ’s notion of confirmation bias and Grice’s theory of conversational im- plicature. The second part wil l introduce Adams’ probabilistic view of indicative conditionals and wil l give reasons for preferring his account to those aforementioned. The conclusion wil l evaluate the question of human rationality in the light of the new standpoint acquired. -/-. (shrink)

"What is required if men and women are to feel at home in society and are to recover their vitality? Into wrestling with that question, Simone Weil put the very substance of her mind and temperament. The apparently solid edifices of our prepossessions fall down before her onslaught like ninepins, and she is as fertile and forthright in her positive suggestions . . . she can be relied upon to toss aside the superficial and to come to grips with (...) the essential and the profound." -- Time Literary Supplement. (shrink)

In 1979, H. Lewis shows that the computational complexity of the Boolean satisfiability problem dichotomizes, depending on the Boolean operations available to formulate instances: intractable (NP-complete) if negation of implication is definable, and tractable (in P) otherwise [21]. Recently, an investigation in the same spirit has been extended to nonclassical propositional logics, modal logics in particular [2, 3]. In this note, we pursue this line in the realm of many-valued propositional logics, and obtain complexity classifications for the parameterized satisfiability problem (...) of two pertinent samples, Kleene and Gödel logics. (shrink)

This book describes a novel methodology for studying algorithmic skills, intended as cognitive activities related to rule-based symbolic transformation, and argues that some human computational abilities may be interpreted and analyzed as genuine examples of extended cognition. It shows that the performance of these abilities relies not only on innate neurocognitive systems or language-related skills, but also on external tools and general agent–environment interactions. Further, it asserts that a low-level analysis, based on a set of core neurocognitive systems linking numbers (...) and language, is not sufficient to explain some specific forms of high-level numerical skills, like those involved in algorithm execution. To this end, it reports on the design of a cognitive architecture for modeling all the relevant features involved in the execution of algorithmic strategies, including external tools, such as paper and pencils. The first part of the book discusses the philosophical premises for endorsing and justifying a position in philosophy of mind that links a modified form of computationalism with some recent theoretical and scientific developments, like those introduced by the so-called dynamical approach to cognition. The second part is dedicated to the description of a Turing-machine-inspired cognitive architecture, expressly designed to formalize all kinds of algorithmic strategies. (shrink)

We propose that procedures of separation have two functions, namely first, to establish the integrity of individual parts, and second, to make previously joint entities discreet and therefore countable. This allows taking stock of available resources, including evaluating the use of individual objects, a process that is especially adaptive under conditions of threat of contagious disease and resource scarcity.

The paper argues that ecology should not be understood as a sectoral issue, i.e. as the object of specific scientific disciplines such as environmental sociology, geology or biology; on the contrary, it is by very nature that ecology should be regarded as a large-scale matter consisting first and foremost in philosophical and political questions. It is the paper’s main objective to claim that there is no way out from the ecological crisis without a critical reconsideration of the dominant socio-economic structures (...) and of the cultural and philosophical background underpinning them. To this end, the present paper resorts to the concept of “social metabolism”. By applying it to various “immaterial elements”, and notably to philosophical systems, the essay investigates their ecological impact. As the paper aims to show, the metabolic analysis of the philosophical system implies adopting and advocating for a renewed transcendental approach. (shrink)

L’articolo si concentra sull’opera per nastro magnetico “La voce dall’Inferno”. Inizialmente concepita come opera radiofonica, composta da Edoardo Torricella e Salvatore Sciarrino, vuole presentare attraverso le sonorità possibili con l’elettronica un approccio al mondo dei dannati che ne risvegli i rumori e le voci, l’acustica del luogo e le presenze. Su questi elementi si concentrerà anche il mio articolo, partendo dallo studio di un otologo sulla Commedia, ci si sposterà a questioni filosofiche ed estetiche che riguardano il rapporto tra la (...) voce e lo spazio, tra la voce e il rumore e l’utilizzo dell’elettronica applicata alla voce. In modo particolare però si cercherà di concentrare l’attenzione, attraverso l’ascolto dell’opera, su di una tematica: come la voce influisca sulla percezione emotiva dell’ambiente sonoro. My essay focuses on the work for tape “La voce dall’Inferno”. Initially conceived as a radio opera, composed by Edoardo Torricella e Salvatore Sciarrino, “La voce dall’Inferno” wants to show through the sounds the world of damned with their noises, voices and their presence in that place. The electronic sounds and the possibilities open by record, freezing, generator and synthesis play an important role in the development and the aesthetic of the opera. On this elements will focus my article. We’ll move to philosophical and aesthetic issues that concern the relationship between voice and space, voice and noise, and the use of electronic instruments. In particular try to focus on a theme by listening to the opera: how the voice influences the emotional perception of the soundscape. (shrink)

Introducing the Selected Works of Simone Weil Some of Simone Weil's most important thinking was done through the medium of her notebooks. She used them in several inter-related ways. First, she used them to note things she had read and was researching. Far more often, they were workbooks where she worked through her ideas. Many of the ideas in her completed essays can first be found in her notebooks, and thus the notebooks are invaluable for adding context and (...) nuance along with a sense of development to the reading of those later essays. Finally, her notebooks simply contain Weil's aphoristic writing at its best in its most striking presentation. For that reason alone, the last two notebooks, which she wrote while in New York and London in 1942-43, published in French as "La Connaissance surnaturel" have been read as books of great wisdom. This volume also includes her first notebook from the year 1934, not long after her time in the factory and its subject matter reflects this period in her life. (shrink)

_Gravity and Grace_ shows Weil's religious thoughts and ideas, drawn from many sources - Christian, Jewish, Indian, Greek and Hindu - and focusing on suffering and redemption. It brings the reader face to face with the profoundest levels of existence as Weil explores the relationship of the human condition to the realm of the transcendent.

Test for the rational acceptance of conditionals and it still incites much of the interest in conditional reasoning. For instance, the test has been considered as a good starting point for several formal semantics for conditionals. Furthermore, its ramifications have important implications for several disciplines, from logic and artificial intelligence to decision theory and psychology. This volume presents a small but fine sample of the state of the art of such multifarious area of research.