Polyploid cells contain multiple copies of all chromosomes. Polyploidization can be developmentally programmed to sustain tissue barrier function or to increase metabolic potential and cell size. Programmed polyploidy is normally associated with terminal differentiation and poor proliferation capacity. Conversely, non‐programmed polyploidy can give rise to cells that retain the ability to proliferate. This can fuel rapid genome rearrangements and lead to diseases like cancer. Here, the mechanisms that generate polyploidy are reviewed and the possible challenges upon polyploid cell division are (...) discussed. The discussion is framed around a recent study showing that asynchronous cell cycle progression (an event that is named “chronocrisis”) of different nuclei from a polyploid cell can generate DNA damage at mitotic entry. The potential mechanisms explaining how mitosis in non‐programmed polyploid cells can generate abnormal karyotypes and genetic instability are highlighted. (shrink)

We prize loyalty in our friends, lovers and colleagues, but loyalty raises difficult questions. What is the point of loyalty? Should we be loyal to country, just as we are loyal to friends and family? Can the requirements of loyalty conflict with the requirements of morality? In this book, originally published in 2007, Simon Keller explores the varieties of loyalty and their psychological and ethical differences, and concludes that loyalty is an essential but fallible part of human life. He (...) argues that grown children can be obliged to be loyal to their parents, that good friendship can sometimes conflict with moral and epistemic standards, and that patriotism is intimately linked with certain dangers and delusions. He goes on to build an approach to the ethics of loyalty that differs from standard communitarian and universalist accounts. His book will interest a wide range of readers in ethics and political philosophy. (shrink)

It is widely recognized that changes are occurring to the earth’s climate and, further, that these changes threaten important human interests. This raises the question of who should bear the burdens of addressing global climate change. This paper aims to provide an answer to this question. To do so it focuses on the principle that those who cause the problem are morally responsible for solving it (the ‘polluterpays’ principle). It argues thatwhilethishasconsiderable appeal it cannot provide a complete account of who (...) should bear the burdens of global climate change. It proposes three ways in which this principle needs to be supplemented, and compares the resulting moral theory with the principle of ‘common but differentiated responsibility’. (shrink)

This essay examines the relationship between climate change and human rights. It argues that climate change is unjust, in part, because it jeopardizes several core rights – including the right to life, the right to food and the right to health. It then argues that adopting a human rights framework has six implications for climate policies. To give some examples, it argues that this helps us to understand the concept of “dangerous anthropogenic interference” (UNFCCC, Article 2). In addition to this, (...) it argues that if we adopt a human rights framework then any climate policies should also honour human rights, and so mitigation policies, for example, should not compromise people’s enjoyment of their human rights. A third implication, I argue, is that in addition to duties of mitigation and adaptation there will also be – if rights are violated – duties of compensation too. (shrink)

Although it is argued that social justice is a core concern for the discipline, nursing has not generally played a leadership role in the responses to many of the greatest social problems of our time. These include the accelerated rate of climate change, pandemic threats, systemic racism, growing health and social inequities, and the regulation of new technologies to ensure an equitable future ‘for all.’ In nursing codes of ethics, administration, education, policies, and practice, social justice is often claimed to (...) be a core value, yet it is rarely contextualized by philosophical or theoretical underpinnings. It appears that nurses’ commitment to social justice may stem more from a penchant for ‘doing good’ than an attempt to explore, understand, and enact what is meant by social justice from an ontological, epistemological, and methodological perspective. We contend that the dominance of a human science perspective in nursing contributes to a narrow definition of health and relegates many issues central to social justice to the margins of nurses’ care. In this article, we explore how the focus on ‘the human’ in the human science perspective may not only be limiting the capacity of nurses to develop strategies to adequately address social injustice, but in some instances, direct nurses to contribute to their very reproduction. We suggest that a critical interrogation of this human‐centric hegemony can identify avenues of rupture and introduce posthumanism as an additional philosophical perspective for consideration to help bridge the human‐social divide. (shrink)

This paper discusses two distinct questions of distributive justice raised by climate change. Stated very roughly, one question concerns how much protection is owed to the potential victims of climate change (the Just Target Question), and the second concerns how the burdens (and benefits) involved in preventing dangerous climate change should be distributed (the Just Burden Question). In Section II, I focus on the first of these questions, the Just Target Question. The rest of the paper examines the second question, (...) the Just Burden Question. To answer this question, I argue, it is necessary to address two important methodological questions (one concerning the choice between what I term Integrationism and Isolationism and the other concerning the choice between what I term Holism and Atomism). Sections III-V, thus, set out and explore these two methodological issues. Having done so, the paper then turns from methodological issues to substantive analysis, and in Section VI it examines three principles of distributive justice that, it has been suggested, should determine how the burden of addressing dangerous climatic changes should be distributed (the Polluter Pays Principle, the Ability to Pay Principle and the Beneficiary Pays Principle). (shrink)

Social scientists have paid insufficient attention to the role of law in constituting the economic institutions of capitalism. Part of this neglect emanates from inadequate conceptions of the nature of law itself. Spontaneous conceptions of law and property rights that downplay the role of the state are criticized here, because they typically assume relatively small numbers of agents and underplay the complexity and uncertainty in developed capitalist systems. In developed capitalist economies, law is sustained through interaction between private agents, courts (...) and the legislative apparatus. Law is also a key institution for overcoming contracting uncertainties. It is furthermore a part of the power structure of society, and a major means by which power is exercised. This argument is illustrated by considering institutions such as property and the firm. Complex systems of law have played a crucial role in capitalist development and are also vital for developing economies. (shrink)

Governments are often so focused on short-term gains that they ignore the long term, thus creating extra unnecessary burdens on their citizens, and violating their responsibilities to future generations. What can be done about this? In this paper I propose a package of reforms to the ways in which policies are made by legislatures, and in which those policies are scrutinised, implemented and evaluated. The overarching aim is to enhance the accountability of the decision-making process in ways that take into (...) account the interests of persons in the future. (shrink)

By examining an exemplar sample of mental health nursing educational policies and related legislation, in this article, we trace the discursive production of madness as an “othered” identity category. We engage in a critical discourse analysis of mental health nursing education in Canada, drawing on provincial and federal policies and legislation as the main sources of data. Theoretically framed by critical posthumanism and mad studies, this article outlines how the mad subjectivity becomes decontextualized out of its identity‐based understanding and recontextualized (...) as an inferior category of “the human,” circulating within discourses of pedagogy, economics, law, and psychiatry. The article maps the intertextual nexus of the discourse of mental health nursing education, making visible the complex, the arbitrary, and the sometimes‐contradictory nature of the discipline's grappling with identity‐based mental health concepts. We close with several implications for nursing policy, education, and practice. (shrink)

In this article, I will discuss two prominent views on the relevance and irrelevance of ontological investigations for the social sciences, namely, ontological foundationalism and anti-ontological pragmatism. I will argue that both views are unsatisfactory. The subsequent part of the article will introduce an alternative role for ontological projects in the philosophy of the social sciences that fares better in this respect by paying attention to the ontological assumptions of actual social scientific theories, models, and related explanatory practices. I will (...) illustrate and support this alternative through discussion of three concrete cases. (shrink)

Broad in its geographic scope and yet grounded in original archival research, this book situates the inception of modern aesthetic theory – the philosophical analysis of art and beauty - in theological contexts that are crucial to explaining why it arose. Simon Grote presents seminal aesthetic theories of the German and Scottish Enlightenments as outgrowths of a quintessentially Enlightenment project: the search for a natural 'foundation of morality' and a means of helping naturally self-interested human beings transcend their own (...) self-interest. This conclusion represents an important alternative to the standard history of aesthetics as a series of preludes to the achievements of Immanuel Kant, as well as a reinterpretation of several canonical figures in the German and Scottish Enlightenments. It also offers a foundation for a transnational history of the Enlightenment without the French philosophes at its centre, while solidly endorsing historians' growing reluctance to call the Enlightenment a secularising movement. (shrink)

_Laclau: A Critical Reader_ is the first full-length critical appraisal of Laclau's work and includes contributions from several leading philosophers and theorists. The first section examines Laclau's theory that the contest between universalism and particularism provides much of the philosophical background to political and social struggle, taking up the important place accorded to, amongst others, Hegel and Lacan in Laclau's work. The second section of the book considers what Laclau's 'radical democracy' might look like and reflects on its ethical implications, (...) particularly in relation to Laclau's post-Marxism and thinkers such as Jürgen Habermas. The final section investigates the place of hegemony in Laclau's work, the idea for which he is perhaps best-known. This stimulating collection also includes replies to his critics by Laclau and the important exchange between Laclau and Judith Butler on equality, making it an excellent companion to Laclau's work and essential reading for students of political and social theory. (shrink)

The chapters in is collection examine various aspects of JJ Rousseau's work as it relates to the concept of desire.

Beginning with a critical examination of the humanist assumptions of critical ethnography, this article interrogates and surfaces problems with the ontological and epistemological orientations of this research methodology. In drawing on exemplar empirical data from an arts‐based project, the article demonstrates the limitations in the humanist‐based qualitative research approach and advances a postdualist, postrepresentationalist direction for critical ethnography called entangled ethnography. Using data from a larger study that examined the perspectives of racialized mad artists, what is demonstrated in this inquiry (...) is that the entanglement of bodies, objects, and meaning‐making practices is central to working with the ontologically excluded, such as those who find themselves in various states of disembodiment and/or corporeal and psychic distribution. We propose the redevelopment of critical ethnography, extended by entanglement theory (a critical posthuman theory), and suggest that for it to be an inclusive methodology, critical ethnography must be conceptualized as in the process of becoming and always in regeneration, open to critique, extension, and redevelopment. (shrink)

Paul Ricoeur and Marya Schechtman express grave doubts about the acceptability and informativeness of the thought-experiments employed by analytic philosophers (notably Derek Parfit) in the debate about personal identity, and for what appear to be related reasons. I consider their reasoning and argue that their reasons fail to justify their doubts. I go on to argue that, from this discussion of possible problems concerning select thought-experiments, something positive can be learned about personal identity.

The attempt to pursue philosophy in the name of phenomenology is one of the most significant and important developments in twentieth century thought. In this bold and innovative book, Simon Glendinning introduces some of its major figures, and demonstrates that its ongoing strength and coherence is to be explained less by what Maurice Merleau-Ponty called the 'unity' of its 'manner of thinking' and more by what he called its 'unfinished nature'. Beginning with a discussion of the nature of phenomenology, (...) Glendinning explores the changing landscape of phenomenology in key texts by Husserl, Heidegger, Sartre, Merleau-Ponty, Levinas and Derrida. Focusing on the different ways in which each philosopher has responded to and transformed the legacy of phenomenology, Glendinning shows that the richness of this legacy lies not in the formation of a distinctive movement or school but in a remarkable capacity to make fertile philosophical breakthroughs. Important topics such as the nature of phenomenological arguments, the critique of realism and idealism, ontology, existentialism, perception, ethics and the other are also closely examined. Through a re-evaluation of the development of phenomenology Glendinning traces the ruptures and dislocations of philosophy that, in an age dominated by science, strive constantly to renew our understanding of ourselves and our place in the world. Clearly and engagingly written, In the Name of Phenomenology is essential reading for students of phenomenology and contemporary philosophy. (shrink)

Many environmental scientists, scholars and activists characterise our situation as one of alienation from nature, but this notion can easily seem meaningless or irrational. In this book, Simon Hailwood critically analyses the idea of alienation from nature and argues that it can be a useful notion when understood pluralistically. He distinguishes different senses of alienation from nature pertaining to different environmental contexts and concerns, and draws upon a range of philosophical and environmental ideas and themes including pragmatism, eco-phenomenology, climate (...) change, ecological justice, Marxism and critical theory. His novel perspective shows that different environmental concerns - both anthropocentric and nonanthropocentric - can dovetail, rather than compete with, each other, and that our alienation from nature need not be something to be regretted or overcome. His book will interest a broad readership in environmental philosophy and ethics, political philosophy, geography and environmental studies. (shrink)

This is an essential guide to an thinker. Frederic Jameson sees Lyotard as responding to a contemporary "crisis of representation" in the sciences -- a crisis which calls into question "an essentially realistic epistemology, which conceives of representation as the reproduction, for subjectivity, of an objectivity that lies outside it -- projects a mirror theory of knowledge and art, whose fundamental evaluative categories are those of adequacy, accuracy, and Truth itself.".

Literature has an ethical obligation to respond to the climate change crisis, and scholars have a responsibility to understand how these responses work. Neither the humanities nor the sciences have a good record when it comes to encouraging people to limit their desires, their consumption, or their growth. While there may be genetic reasons for this failure, calls for humanity to limit itself need better responses. Literature can help us to respond better to climate change, but only if we reconceptualize (...) narrative and accord to it the importance it once held as a source not only of entertainment but of knowledge necessary for our very survival. (shrink)

This paper is concerned with two senses of disowning in the context of climate change and human modification of nature generally. In one of these senses disowning is something to be encouraged; but in the other sense discussed here, disowning is to be discouraged. Both raise problems for liberal theory. There is no space here to do little more than indicate some of these problems; consequently the paper is mainly negative and critical in tone. Although I focus mainly on the (...) other sense, I begin in the first part of the paper with the kind of disowning to be discouraged. This is the tendency to deny, or ignore, the responsibility we have for – and in that way ‘disown’ – the world we are in fact in the process of making including its climatic component. The other sense of disowning I go on to discuss mainly in relation to Hegel’s account of property. (shrink)

"While it is true that Yves R. Simon did not intend this to be a history book, __The Ethiopian Campaign and French Political Thought __is an important historical work well deserving of a close reading by students of twentieth-century European history and international relations. This book, which finds a worthy English translation after too many years, was Simon's first serious foray into the public square on the side of justice and the common good. Simon's analysis is wide-ranging, (...) incisive, and brimming with far-sighted political acumen." --_Robert Ventresca, King's University College_ "The Italian invasion of Ethiopia in 1935 led to the memorable plea of Emperor Haile Selassie before the League of Nations as his country's freedom died. Easier to forget is that it also sparked a surprisingly familiar intellectual dispute over the legitimacy of the bombing and the relevance of international law, as depressingly many European intellectuals rallied behind Benito Mussolini's campaign as a defense of the West and the cause of 'civilization.' The unsparing critique leveled against these frequently religious apologists for imperialism by Yves Simon, French Catholic thinker and later American university professor, is an eye-opening reminder of the terms of debate, and the larger constellation of forces of the turbulent era. Anthony Simon and his colleagues deserve thanks for making this precious and moving document available, since its ethical kernel, like its model of Catholic intellectualism, remain highly relevant." --_Samuel Moyn, Columbia University_ "__The Ethiopian Campaign and French Political Thought_ _offers a very important discussion grounded in traditional metaphysics and in a sound sense of historical circumstances. This little book is a gem. --_George Anastaplo, Loyola University of Chicago_ Yves Simon was one of the preeminent Thomistic philosophers and political theorists of the twentieth century. He saw it as a moral duty to understand human reality and to use philosophical analysis to examine contemporary politics when they embodied philosophical errors or vicious ideologies. In __The Ethiopian Campaign and French Political Thought__, Simon extracts principles from the 1894 Dreyfus Affair in France and applies them to Italy's 1935 invasion of Ethopia. As Simon's analysis shows, the relatively obscure events leading up to the Italian invasion had larger implications for Europe and the world, perhaps even paving the way for Vichy France's collaboration with Hitler's German New Order. This book, available for the first time in English, offers an interesting case study of such ethical concerns as just war theory and pre-emptive war, and is of particular relevance in our modern political climate. (shrink)

The Repugnant Conclusion and its paradoxes pose a significant problem for outcome evaluation. Derek Parfit has suggested that we may be able to resolve this problem by accepting a view he calls ‘Perfectionism’, which gives lexically superior value to ‘the best things in life’. In this paper, I explore perfectionism and its potential to solve this problem. I argue that perfectionism provides neither a sufficient means of avoiding the Repugnant Conclusion nor a full explanation of its repugnance. This is because (...) even lives that are ‘barely worth living’ may contain the best things in life if they also contain sufficient ‘bad things’, such as suffering or frustration. Therefore, perfectionism can only fully explain or avoid the Repugnant Conclusion if combined with other claims, such as that bad things have an asymmetrical value relative to many good things. This combined view faces the objection that any such asymmetry implies Parfit’s ‘Ridiculous Conclusion’. However, I argue that perfectionism itself faces very similar objections, and that these are question-begging against both views. Finally, I show how the combined view that I propose not only explains and avoids the Repugnant Conclusion but also allows us to escape many of its paradoxes as well. (shrink)

ABSTRACTLike Kant a little over a hundred years earlier, Nietzsche saw the history of Europe as moving towards the formation of an integrated political union. Unlike Kant, however, Nietzsche does not see this development as an unambiguous good. Kant had supposed that European integration would belong to a history of constitutional improvements that would make war between what we would now call “democratic” states in Europe increasingly less likely. Nietzsche also sees it as part of a process of democratization, but (...) he understands that as a movement of “levelling and mediocritizing” of the European peoples, making Europeans into serviceable herd animals, “weak willed highly employable workers”. The general trend of European democratization is simply a movement towards the production of a type that is “prepared for slavery in the subtlest sense”. Nietzsche does not think this is a wholly unhappy development, however, because he thinks the same conditions will also bring about something that he welcomes: “th... (shrink)

The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) was published in 2013 containing the following changes from the previous edition: gone are the subcategories ‘Autistic Disorder,’ ‘Asperger Syndrome’ and ‘PDD-NOS,’ replaced by the single diagnosis ‘Autism Spectrum Disorder,’ and there is a new category ‘Social Communication Disorder.’ In this paper I consider what kind of reasons would justify these changes if one were (a) a realist about autism, or (b) one were a constructivist. I explore (...) various analyses of autism in the research literature that portray it as essentially either a psychological, neurological or genetic phenomenon, and discuss these by reference to the diagnostic criteria and by analogy with the way we understand race and sex categories. I conclude that no realist reasons are available to justify the changes in the diagnostic criteria, and further, that the only way the changes could be justified is if one takes the position that the DSM categories are social constructs. I conclude by exploring what implications follow from this. (shrink)