Polyploid cells contain multiple copies of all chromosomes. Polyploidization can be developmentally programmed to sustain tissue barrier function or to increase metabolic potential and cell size. Programmed polyploidy is normally associated with terminal differentiation and poor proliferation capacity. Conversely, non‐programmed polyploidy can give rise to cells that retain the ability to proliferate. This can fuel rapid genome rearrangements and lead to diseases like cancer. Here, the mechanisms that generate polyploidy are reviewed and the possible challenges upon polyploid cell division are (...) discussed. The discussion is framed around a recent study showing that asynchronous cell cycle progression (an event that is named “chronocrisis”) of different nuclei from a polyploid cell can generate DNA damage at mitotic entry. The potential mechanisms explaining how mitosis in non‐programmed polyploid cells can generate abnormal karyotypes and genetic instability are highlighted. (shrink)

Although it is argued that social justice is a core concern for the discipline, nursing has not generally played a leadership role in the responses to many of the greatest social problems of our time. These include the accelerated rate of climate change, pandemic threats, systemic racism, growing health and social inequities, and the regulation of new technologies to ensure an equitable future ‘for all.’ In nursing codes of ethics, administration, education, policies, and practice, social justice is often claimed to (...) be a core value, yet it is rarely contextualized by philosophical or theoretical underpinnings. It appears that nurses’ commitment to social justice may stem more from a penchant for ‘doing good’ than an attempt to explore, understand, and enact what is meant by social justice from an ontological, epistemological, and methodological perspective. We contend that the dominance of a human science perspective in nursing contributes to a narrow definition of health and relegates many issues central to social justice to the margins of nurses’ care. In this article, we explore how the focus on ‘the human’ in the human science perspective may not only be limiting the capacity of nurses to develop strategies to adequately address social injustice, but in some instances, direct nurses to contribute to their very reproduction. We suggest that a critical interrogation of this human‐centric hegemony can identify avenues of rupture and introduce posthumanism as an additional philosophical perspective for consideration to help bridge the human‐social divide. (shrink)

By examining an exemplar sample of mental health nursing educational policies and related legislation, in this article, we trace the discursive production of madness as an “othered” identity category. We engage in a critical discourse analysis of mental health nursing education in Canada, drawing on provincial and federal policies and legislation as the main sources of data. Theoretically framed by critical posthumanism and mad studies, this article outlines how the mad subjectivity becomes decontextualized out of its identity‐based understanding and recontextualized (...) as an inferior category of “the human,” circulating within discourses of pedagogy, economics, law, and psychiatry. The article maps the intertextual nexus of the discourse of mental health nursing education, making visible the complex, the arbitrary, and the sometimes‐contradictory nature of the discipline's grappling with identity‐based mental health concepts. We close with several implications for nursing policy, education, and practice. (shrink)

Deconstruction and pragmatism constitute two of the major intellectual influences on the contemporary theoretical scene; influences personified in the work of Jacques Derrida and Richard Rorty. Both Rortian pragmatism, which draws the consequences of post-war developments in Anglo-American philosophy, and Derridian deconstruction, which extends and troubles the phonomenological and Heideggerian influence on the Continental tradition, have hitherto generally been viewed as mutually exclusive philosophical language games. The purpose of this volume is to bring deconstruction and pragmatism into critical confrontation with (...) one another through staging a debate between Derrida and Rorty, itself based on discussions that took place at the College International de Philosophie in Paris in 1993. The ground for this debate is layed out in introductory papers by Simon Critchley and Ernesto Laclau, and the remainder of the volume records Derrida's and Rorty's responses to each other's work. Chantal Mouffe gives an overview of the stakes of this debate in a helpful preface. (shrink)

The chapters in is collection examine various aspects of JJ Rousseau's work as it relates to the concept of desire.

Beginning with a critical examination of the humanist assumptions of critical ethnography, this article interrogates and surfaces problems with the ontological and epistemological orientations of this research methodology. In drawing on exemplar empirical data from an arts‐based project, the article demonstrates the limitations in the humanist‐based qualitative research approach and advances a postdualist, postrepresentationalist direction for critical ethnography called entangled ethnography. Using data from a larger study that examined the perspectives of racialized mad artists, what is demonstrated in this inquiry (...) is that the entanglement of bodies, objects, and meaning‐making practices is central to working with the ontologically excluded, such as those who find themselves in various states of disembodiment and/or corporeal and psychic distribution. We propose the redevelopment of critical ethnography, extended by entanglement theory (a critical posthuman theory), and suggest that for it to be an inclusive methodology, critical ethnography must be conceptualized as in the process of becoming and always in regeneration, open to critique, extension, and redevelopment. (shrink)

This is an essential guide to an thinker. Frederic Jameson sees Lyotard as responding to a contemporary "crisis of representation" in the sciences -- a crisis which calls into question "an essentially realistic epistemology, which conceives of representation as the reproduction, for subjectivity, of an objectivity that lies outside it -- projects a mirror theory of knowledge and art, whose fundamental evaluative categories are those of adequacy, accuracy, and Truth itself.".

Literature has an ethical obligation to respond to the climate change crisis, and scholars have a responsibility to understand how these responses work. Neither the humanities nor the sciences have a good record when it comes to encouraging people to limit their desires, their consumption, or their growth. While there may be genetic reasons for this failure, calls for humanity to limit itself need better responses. Literature can help us to respond better to climate change, but only if we reconceptualize (...) narrative and accord to it the importance it once held as a source not only of entertainment but of knowledge necessary for our very survival. (shrink)

This paper is concerned with two senses of disowning in the context of climate change and human modification of nature generally. In one of these senses disowning is something to be encouraged; but in the other sense discussed here, disowning is to be discouraged. Both raise problems for liberal theory. There is no space here to do little more than indicate some of these problems; consequently the paper is mainly negative and critical in tone. Although I focus mainly on the (...) other sense, I begin in the first part of the paper with the kind of disowning to be discouraged. This is the tendency to deny, or ignore, the responsibility we have for – and in that way ‘disown’ – the world we are in fact in the process of making including its climatic component. The other sense of disowning I go on to discuss mainly in relation to Hegel’s account of property. (shrink)

The question of whether donors should be able to set conditions on who can receive their tissue has been discussed by bioethicists, but so far there has been little consideration of whether the answer to this question should be different depending on the type of tissue under discussion. In this article, we compare the donation of organs with the donation of reproductive material such as sperm, eggs, and embryos, exploring possible arguments for allowing donors to set conditions in one case (...) but not the other. After considering arguments from procreative liberty, special parental obligations, and donors meeting their genetic offspring, we find that there is no ethically defensible reason to have different policies between these two cases. As a consequence, we conclude that jurisdictions operating with this inconsistency should consider moving their policies into better alignment. We also make some recommendations for the standardisation of the terminology around conditional donation. (shrink)

Mobility has become a central topic of contemporary social research with the mobility turn initiated in the 2000s. In order to grasp the complexity of the global order, its authors have attempted to decenter the importance of human subjectivity and to envisage a “sociology beyond societies”. The present paper considers this interpretive context to demonstrate the contemporary relevance of Alfred Schutz’s theory of action, and to propose a notion of mobility intrinsically linked to the performance of subjectivity. By revisiting the (...) distinction between action as a thing produced and as an ongoing process, the notion of mobility is detailed in relation to movement in space and to the subjective flow of time. The specific type of action Schutz calls “locomotion” in his later work enables us to understand how action involves bodily operations in configuring a common space of sociality and communication. I conclude by going beyond the explanation of action in terms of its starting point and end point, and by assessing how action unfolds through the experiential life of the subject, with its new meanings and unexpected changes. (shrink)

The Repugnant Conclusion and its paradoxes pose a significant problem for outcome evaluation. Derek Parfit has suggested that we may be able to resolve this problem by accepting a view he calls ‘Perfectionism’, which gives lexically superior value to ‘the best things in life’. In this paper, I explore perfectionism and its potential to solve this problem. I argue that perfectionism provides neither a sufficient means of avoiding the Repugnant Conclusion nor a full explanation of its repugnance. This is because (...) even lives that are ‘barely worth living’ may contain the best things in life if they also contain sufficient ‘bad things’, such as suffering or frustration. Therefore, perfectionism can only fully explain or avoid the Repugnant Conclusion if combined with other claims, such as that bad things have an asymmetrical value relative to many good things. This combined view faces the objection that any such asymmetry implies Parfit’s ‘Ridiculous Conclusion’. However, I argue that perfectionism itself faces very similar objections, and that these are question-begging against both views. Finally, I show how the combined view that I propose not only explains and avoids the Repugnant Conclusion but also allows us to escape many of its paradoxes as well. (shrink)