This study investigates the association between work-family conflict and organizational citizenship behavior and examines the mediated role of subjective happiness between and the moderated part of family support. A moderated mediation model is established based on the Conservation of Resources theory. We collected data from 386 employees of nine companies in China. This study shows that the work-family conflict of female professional employees is negatively correlated with organizational citizenship behavior, and that the relationship is mediated by subjective well-being. Furthermore, female (...) professional employees’ family support moderates the effects of work-family conflict on subjective happiness and organizational citizenship behavior, with the relationship weaker when family support is higher. This study enriches the literature on work-family conflict by using family support as a mediating mechanism for work-family conflict. It enhanced our understanding of the influencing mechanisms of organizational citizenship behavior by constructing a more detailed model. (shrink)

The question of if, and under what conditions transsexuals should be allowed to participate in sports in their acquired sex is becoming increasingly relevant partly because the number of transsexuals is increasing partly because many countries now provide mechanisms for achieving legal recognition as belonging to the new acquired sex. This paper develops (1) an analysis of the justification for maintaining sex segregation in some sports and (2) an account of the rights of transsexuals to be recognised in their new (...) sex. On the basis of these two analyses it critically evaluates two set of rules for the participation of transsexuals in elite sports: the UK guidelines issued in pursuance of the Gender Recognition Act 2004 and the International Olympic Committee's guidelines. It is argued that these guidelines are conflicting and that a modified set of criteria is more justifiable. (shrink)

The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

The Covid-19 pandemic creates an unprecedented threatening situation worldwide with an urgent need for critical reflection and new knowledge production, but also a need for imminent action despite prevailing knowledge gaps and multilevel uncertainty. With regard to the role of research ethics in these pandemic times some argue in favor of exceptionalism, others, including the authors of this paper, emphasize the urgent need to remain committed to core ethical principles and fundamental human rights obligations all reflected in research regulations and (...) guidelines carefully crafted over time. In this paper we disentangle some of the arguments put forward in the ongoing debate about Covid-19 human challenge studies (CHIs) and the concomitant role of health-related research ethics in pandemic times. We suggest it might be helpful to think through a lens differentiating between risk, strict uncertainty and ignorance. We provide some examples of lessons learned by harm done in the name of research in the past and discuss the relevance of this legacy in the current situation. (shrink)

In this paper, we propose a new mathematical model of retrieval of intentions from long-term memory. We model retrieval as a stochastic race between a plurality of potentially relevant intentions stored in long-term memory. Psychological theories are dominated by two opposing conceptions of the role of memory in temporally extended agency – as when a person has to remember to make a phone call in the afternoon because, in the morning, she promised she would do so. According to the Working (...) Memory conception, remembering to make the phone call is explained in terms of the construction and maintenance of intentions in working-memory. According to the Long-Term Memory conception, we should explain the episode in terms of an ability to store intentions in long-term memory. The two conceptions predict different processing profiles. The aim of this paper is to present a new mathematical model of the type of memory mechanism that could realise the long-term memory representations of intentions necessary for the Long-Term Memory conception. We present and illustrate the formal model and propose a new type of experimental paradigm that could allow us to test which of the two conceptions provides the best explanation of the role of memory in temporally extended agency. (shrink)

This article discusses the role that algorithmic thinking and management play in health care and the kind of exclusions this might create. We argue that evidence‐based medicine relies on research and data to create pathways for patient journeys. Coupled with data‐based algorithmic prediction tools in health care, they establish what could be called health care algorithmics—a mode of management of healthcare that produces forms of algorithmic governmentality. Relying on a critical posthumanist perspective, we show how healthcare algorithmics is contingent on (...) the way authority over bodies is produced and how predictive health care algorithms can reproduce inequalities of the worlds from which they are made, centreing possible futures on existing normativities regulated through algorithmic biopower. In contrast to that, we explore posthuman speculative ethics as a way to challenge understanding of ‘ethics’ and ‘care’ in healthcare algorithmics. We suggest some possible avenues towards working speculative ethics into health care while still being critically attentive to algorithmic modes of management and prediction in health care. (shrink)

The ongoing legal and bioethics debates on consent requirements for collecting, storing, and utilizing human biological material for purposes of basic and applied research—that is, genomic research biobanking—have already managed to pass through three ostensibly dissimilar stages.

The volume advances research in the philosophy of technology by introducing contributors who have an acute sense of how to get beyond or reframe the epistemic, ontological and normative limitations that currently limit the fields of philosophy of technology and science and technology studies.

Is it fair for employers to select candidates partly based on how the employers think customers react to the candidates' appearances, that is, based on candidates' reaction qualifications? Both philosophically (in the literature on wrongful discrimination) and empirically, this question has recently been getting attention. Here, we focus on a theory of unfair disadvantages emphasizing (i) whether the possession of the appearance feature in question reflects choices on the part of the candidate and (ii) whether the appearance feature in question (...) reflects values or convictions of importance to the candidate. We scrutinize the theory by evaluating how well these factors map on to folk intuitions about wrongful discrimination using an experimental-philosophical approach and data from the United States. We do so on the presumption that coherence with folk intuitions is one desideratum for a philosophical theory and that attention should be given to potential discrepancies between philosophical theories and folk intuitions. Our central finding is that there is only general support for factor (i), not (ii), in the American population. Our study also adds to the extant empirical literature on reaction qualifications that tend to focus on the employer's side of the matter, not the candidate's as we do. (shrink)

Sports referees are not always as unbiased or impartial as they ideally should be. Studies have shown, for example, that in their decisions, referees seem to be biased against people of different r...

Is it fair for employers to select candidates partly based on how the employers think customers react to the candidates' appearances, that is, based on candidates' reaction qualifications? Both philosophically (in the literature on wrongful discrimination) and empirically, this question has recently been getting attention. Here, we focus on a theory of unfair disadvantages emphasizing (i) whether the possession of the appearance feature in question reflects choices on the part of the candidate and (ii) whether the appearance feature in question (...) reflects values or convictions of importance to the candidate. We scrutinize the theory by evaluating how well these factors map on to folk intuitions about wrongful discrimination using an experimental-philosophical approach and data from the United States. We do so on the presumption that coherence with folk intuitions is one desideratum for a philosophical theory and that attention should be given to potential discrepancies between philosophical theories and folk intuitions. Our central finding is that there is only general support for factor (i), not (ii), in the American population. Our study also adds to the extant empirical literature on reaction qualifications that tend to focus on the employer's side of the matter, not the candidate's as we do. (shrink)

Flap EndoNuclease‐1 (FEN‐1) is a multifunctional and structure‐specific nuclease involved in nucleic acid processing pathways. It plays a critical role in maintaining human genome stability through RNA primer removal, long‐patch base excision repair and resolution of dinucleotide and trinucleotide repeat secondary structures. In addition to its flap endonuclease (FEN) and nick exonuclease (EXO) activities, a new gap endonuclease (GEN) activity has been characterized. This activity may be important in apoptotic DNA fragmentation and in resolving stalled DNA replication forks. The multiple (...) functions of FEN‐1 are regulated via several means, including formation of complexes with different protein partners, nuclear localization in response to cell cycle or DNA damage and post‐translational modifications. Its functional deficiency is predicted to cause genetic diseases, including Huntington's disease, myotonic dystrophy and cancers. This review summarizes the knowledge gained through efforts in the past decade to define its structural elements for specific activities and possible pathological consequences of altered functions of this multirole player. BioEssays 27:717–729, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This chapter contains sections titled: Bioethics Genethics Medical Ethics.

Creative association is inherent and essential to creativity and insight. Here we utilised a Chinese compound Remote Associates Task (cRAT) to identify the potential impact of word order (i.e., solution position hereinafter) and word frequency on creative association across two behavioural experiments. Experiment 1 identified the effects of (a) word order and word frequency on cRAT-induced association without considering the specific strategies used during solving such problems and (b) their interaction not only on performance in solving the cRAT, including solution (...) time and accuracy, but also on difficulty rating. Following a coarse-to-fine approach, Experiment 2 examined the effect of both factors on creative association determined according to each participant’s trial-by-trial reports regarding insight solution strategies. Main effects of word order and word frequency, and a two-way interaction, were found on the accuracy and self-rated difficulty. These findings shed light on creative association, multiply-constrained problem solving and constructing compounds. (shrink)

The Meaning in Life Questionnaire is a popular tool to measure the presence of and one’s search for meaning in life. Although the validity of the MLQ has been verified in previous studies, the evidence from longitudinal measurement invariance of the MLQ is still lacking. The current study aimed to examine the LMI of the MLQ in a sample of Chinese college students at a 1-year interval. Multigroup confirmatory factor analysis was used to examine the LMI of the MLQ over (...) four time points. Results indicate that the MLQ has strict longitudinal invariance across 1-year in Chinese college students, and the latent means difference of MLQ-P is not significant differences across time, while the latent means difference of MLQ-S show significant differences between Time 1 and the other time points. Moreover, the internal consistency reliabilities of the MLQ scores were acceptable at all four time points, and the stability coefficients across time were moderate. These findings provide preliminary evidence that the MLQ has satisfactory longitudinal properties in Chinese college students. (shrink)

The “happiness agenda” is a worldwide movement that claims that happiness is the highest good, happiness can be measured, and public policy should promote happiness. Against Happiness is a thorough and powerful critique of this program, revealing the flaws of its concept of happiness and advocating a renewed focus on equality and justice. Written by an interdisciplinary team of authors, this book provides both theoretical and empirical analysis of the limitations of the happiness agenda. The authors emphasize that this movement (...) draws on a parochial, Western-centric philosophical basis and demographic sample. They show that happiness defined as subjective satisfaction or a surplus of positive emotions bears little resemblance to the richer and more nuanced concepts of the good life found in many world traditions. Cross-cultural philosophy, comparative theology, and social and cultural psychology all teach that cultures and subcultures vary in how much value they place on life satisfaction or feeling happy. Furthermore, the ideas promoted by the happiness agenda can compete with rights, justice, sustainability, and equality—and even conceal racial and gender injustice. Against Happiness argues that a better way forward requires integration of cross-cultural philosophical, ethical, and political thought with critical social science. Ultimately, the authors contend, happiness should be a secondary goal—worth pursuing only if it is contingent on the demands of justice. (shrink)

The volume advances research in the philosophy of technology by introducing contributors who have an acute sense of how to get beyond or reframe the epistemic, ontological and normative limitations that currently limit the fields of philosophy of technology and science and technology studies.

How does perception provide reasons for our empirical judgements? This volume offers a set of new essays which in different ways address this fundamental question, and investigate the implications for our understanding of perceptual experience.

In this paper, a data-driven superheating control strategy is developed for organic Rankine cycle processes. Due to non-Gaussian stochastic disturbances imposed on heat sources, the quantized minimum error entropy is adopted to construct the performance index of superheating control systems. Furthermore, particle swarm optimization algorithm is applied to obtain optimal control law by minimizing the performance index. The implementation procedures of the presented superheating control system in an ORC-based waste heat recovery process are presented. The simulation results testify the effectiveness (...) of the presented control algorithm. (shrink)